aldesulfone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antimycobacterials, diaminodiphenylsulfone derivatives	2533	144-75-2

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

aldesulfone sodium
aldapsone
sodium aldesulphone
aldesulfone
sodium sulfoxone
sulfoxone sodium
sulfoxone
diasone sodium

Molecular weight: 404.47
Formula: C14H16N2O6S3
CLOGP: -1.21
LIPINSKI: 0
HAC: 8
HDO: 4
TPSA: 132.80
ALOGS: -2.19
ROTB: 8

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.33	g	O

ADMET properties:

Property	Value	Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)	12.36 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

Date	Agency	Company	Orphan
May 24, 1974	FDA	ABBVIE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	J04BA03	ANTIINFECTIVES FOR SYSTEMIC USE ANTIMYCOBACTERIALS DRUGS FOR TREATMENT OF LEPRA Drugs for treatment of lepra

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	2.5	acidic
pKa2	3.1	acidic
pKa3	4.06	Basic
pKa4	3.46	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Glucose-6-phosphate 1-dehydrogenase	Enzyme	P11413	G6PD_HUMAN					WOMBAT-PK
Dihydropteroate synthase 1	Enzyme		DHPS1_MYCLE	INHIBITOR				CHEMBL	CHEMBL

External reference:

ID	Source
D02521	KEGG_DRUG
144-76-3	SECONDARY_CAS_RN
C0075606	UMLSCUI
CHEBI:135651	CHEBI
CHEMBL1570	ChEMBL_ID
CHEMBL1200580	ChEMBL_ID
DB01145	DRUGBANK_ID
C036115	MESH_SUPPLEMENTAL_RECORD_UI
5351	PUBCHEM_CID
003005	NDDF
004972	NDDF
91266006	SNOMEDCT_US
971	INN_ID
57OWB0Q221	UNII

Pharmaceutical products:

None