asulacrine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
acridine derivatives	252	80841-47-0

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

asulacrine
amsalog

derivative of amsacrine; structure given in first source

Molecular weight: 464.54
Formula: C24H24N4O4S
CLOGP: 4.37
LIPINSKI: 0
HAC: 8
HDO: 3
TPSA: 109.42
ALOGS: -5.06
ROTB: 5

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	34 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	0.30 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	2.60 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.00 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	2.40 hours	Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D059005	Topoisomerase II Inhibitors
MeSH PA	D059003	Topoisomerase Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.86	acidic
pKa2	11.92	acidic
pKa3	7.74	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
DNA topoisomerase 2-alpha	Enzyme	P11388	TOP2A_HUMAN					WOMBAT-PK

External reference:

ID	Source
C0130561	UMLSCUI
CHEBI:135753	CHEBI
CHEMBL48880	ChEMBL_ID
C042315	MESH_SUPPLEMENTAL_RECORD_UI
S8P50T62B6	UNII
107924	PUBCHEM_CID

Pharmaceutical products:

None