Stem definition | Drug id | CAS RN |
---|---|---|
anti-infectives, sulfonamides | 2529 | 127-69-5 |
Dose | Unit | Route |
---|---|---|
4 | g | O |
4 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 4 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.13 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 49 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 249.52 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 96 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.17 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 0.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.08 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 7.40 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
June 7, 1971 | FDA | ALRA |
None
None
None
None
Source | Code | Description |
---|---|---|
ATC | J01EB05 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE SULFONAMIDES AND TRIMETHOPRIM Short-acting sulfonamides |
ATC | S01AB02 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Sulfonamides |
FDA CS | M0020790 | Sulfonamides |
FDA EPC | N0000175504 | Sulfonamide Antimicrobial |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
MeSH PA | D000977 | Antiparasitic Agents |
MeSH PA | D000981 | Antiprotozoal Agents |
MeSH PA | D003049 | Coccidiostats |
CHEBI has role | CHEBI:36047 | antibacterial drugs |
CHEBI has role | CHEBI:88188 | allergenic drug |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Trachoma | indication | 2576002 | DOID:11265 |
Acute otitis media | indication | 3110003 | |
Haemophilus Influenzae Acute Otitis Media | indication | 19021002 | |
Nocardiosis | indication | 29227009 | DOID:2312 |
Falciparum malaria | indication | 62676009 | DOID:14067 |
Urinary tract infectious disease | indication | 68566005 | |
Urethritis due to Chlamydia trachomatis | indication | 179101003 | |
Meningococcal meningitis | indication | 192644005 | |
Chlamydial conjunctivitis | indication | 231861005 | DOID:13800 |
Chancroid | indication | 266143009 | DOID:13778 |
Infective otitis media | indication | 312218008 | |
Pneumococcal Acute Otitis Media | indication | ||
Chlamydia Cervicitis | indication | ||
Lymphogranuloma venereum | off-label use | 186946009 | DOID:13819 |
Urinary tract obstruction | contraindication | 7163005 | DOID:5200 |
Torsades de pointes | contraindication | 31722008 | |
Glomerulonephritis | contraindication | 36171008 | DOID:2921 |
Acute hepatitis | contraindication | 37871000 | |
Third trimester pregnancy | contraindication | 41587001 | |
Uremia | contraindication | 44730006 | DOID:4676 |
Megaloblastic anemia due to folate deficiency | contraindication | 85649008 | DOID:14026 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Cholestatic hepatitis | contraindication | 95556007 | |
Anemia due to enzyme deficiency | contraindication | 111577008 | |
Prolonged QT interval | contraindication | 111975006 | |
Deficiency of glucose-6-phosphate dehydrogenase | contraindication | 124134002 | DOID:2862 |
Gastrointestinal obstruction | contraindication | 126765001 | |
Hearing disorder | contraindication | 128540005 | |
Liver function tests abnormal | contraindication | 166603001 | |
Disease of blood AND/OR blood-forming organ | contraindication | 191124002 | DOID:74 |
Asthma | contraindication | 195967001 | DOID:2841 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Aplastic anemia | contraindication | 306058006 | DOID:12449 |
Pseudomembranous enterocolitis | contraindication | 397683000 | |
Porphyria | contraindication | 418470004 | |
Slow acetylator due to N-acetyltransferase enzyme variant | contraindication | 425079005 | |
Congenital long QT syndrome | contraindication | 442917000 |
Species | Use | Relation |
---|---|---|
Cats | Bacterial pneumonia | Indication |
Cats | Bacterial enteritis | Indication |
Dogs | Bacterial pneumonia | Indication |
Dogs | Bacterial enteritis | Indication |
Product | Applicant | Ingredients |
---|---|---|
Soxisol Tablets | Zoetis Inc. | 1 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 5.0 | acidic |
pKa2 | 2.08 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Histamine H4 receptor | GPCR | IC50 | 5.55 | WOMBAT-PK | |||||
Endothelin-1 receptor | GPCR | IC50 | 6.11 | CHEMBL | |||||
Endothelin B receptor | GPCR | IC50 | 4.62 | CHEMBL | |||||
Dihydropteroate synthase | Enzyme | INHIBITOR | DRUGBANK | CHEMBL | |||||
Dihydroorotate dehydrogenase (quinone), mitochondrial | Enzyme | WOMBAT-PK | |||||||
Endothelin-1 receptor | GPCR | IC50 | 6.11 | CHEMBL |
ID | Source |
---|---|
4017767 | VUID |
N0000178993 | NUI |
D00450 | KEGG_DRUG |
4017765 | VANDF |
4017767 | VANDF |
C0038745 | UMLSCUI |
CHEBI:102484 | CHEBI |
CHEMBL453 | ChEMBL_ID |
CHEMBL1200321 | ChEMBL_ID |
DB00263 | DRUGBANK_ID |
12700 | IUPHAR_LIGAND_ID |
4299-60-9 | SECONDARY_CAS_RN |
5344 | PUBCHEM_CID |
10207 | RXNORM |
5531 | MMSL |
5533 | MMSL |
7990 | MMSL |
d00120 | MMSL |
002818 | NDDF |
002820 | NDDF |
108866009 | SNOMEDCT_US |
372858002 | SNOMEDCT_US |
80732005 | SNOMEDCT_US |
D013444 | MESH_DESCRIPTOR_UI |
D013411 | MESH_DESCRIPTOR_UI |
4177 | INN_ID |
740T4C525W | UNII |
None