sulfathiazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
anti-infectives, sulfonamides	2527	72-14-0

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: sulfathiazole norsulfasol norsulfazol norsulfazole sulfanilamidothiazole sulfathiazol sulphathiazole thiozamide thiazamide	A sulfathiazole compound that is used as a short-acting anti-infective agent. It is no longer commonly used systemically due to its toxicity, but may still be applied topically in combination with other drugs for the treatment of vaginal and skin infections, and is still used in veterinary medicine. Molecular weight: 255.31 Formula: C9H9N3O2S2 CLOGP: 0.73 LIPINSKI: 0 HAC: 5 HDO: 2 TPSA: 85.08 ALOGS: -2.44 ROTB: 2 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

sulfathiazole
norsulfasol
norsulfazol
norsulfazole
sulfanilamidothiazole
sulfathiazol
sulphathiazole
thiozamide
thiazamide

A sulfathiazole compound that is used as a short-acting anti-infective agent. It is no longer commonly used systemically due to its toxicity, but may still be applied topically in combination with other drugs for the treatment of vaginal and skin infections, and is still used in veterinary medicine.

Molecular weight: 255.31
Formula: C9H9N3O2S2
CLOGP: 0.73
LIPINSKI: 0
HAC: 5
HDO: 2
TPSA: 85.08
ALOGS: -2.44
ROTB: 2

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Sept. 12, 1945	FDA	ORTHO MCNEIL PHARM

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Swollen joint count increased	93.30	58.22	48	4681	36006	63448287
Rheumatic fever	90.71	58.22	50	4679	43061	63441232
Rheumatoid factor positive	88.82	58.22	63	4666	84343	63399950
Anti-cyclic citrullinated peptide antibody positive	87.48	58.22	71	4658	116141	63368152
Duodenal ulcer perforation	86.97	58.22	63	4666	87146	63397147
Muscle injury	83.50	58.22	55	4674	65290	63419003
Folliculitis	79.83	58.22	55	4674	70262	63414031
Helicobacter infection	79.06	58.22	61	4668	92724	63391569
Irritable bowel syndrome	74.21	58.22	56	4673	82356	63401937
Wound	74.03	58.22	75	4654	163188	63321105

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FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Duodenal ulcer perforation	54.28	50.28	30	2305	66181	79675872

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	D06BA02	DERMATOLOGICALS ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE CHEMOTHERAPEUTICS FOR TOPICAL USE Sulfonamides
ATC	J01EB07	ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE SULFONAMIDES AND TRIMETHOPRIM Short-acting sulfonamides
CHEBI has role	CHEBI:35441	antiinfective agents
CHEBI has role	CHEBI:35703	Xenobiotic
CHEBI has role	CHEBI:50502	dihydropteroate synthase inhibitors
CHEBI has role	CHEBI:78298	environmental contaminants
CHEBI has role	CHEBI:88188	allergenic drug
MeSH PA	D000890	Anti-Infective Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Vulvovaginitis	indication	53277000	DOID:2273
Gardnerella Vaginalis Bacterial Vaginosis	indication
Kidney disease	contraindication	90708001	DOID:557
Anemia due to enzyme deficiency	contraindication	111577008
Deficiency of glucose-6-phosphate dehydrogenase	contraindication	124134002	DOID:2862
Disease of blood AND/OR blood-forming organ	contraindication	191124002	DOID:74
Disease of liver	contraindication	235856003	DOID:409
Breastfeeding (mother)	contraindication	413712001
Porphyria	contraindication	418470004

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.16	acidic
pKa2	2.48	Basic
pKa3	1.61	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Endothelin-1 receptor	GPCR	P25101	EDNRA_HUMAN		IC50	4.16	WOMBAT-PK
Dihydropteroate synthase	Enzyme		DHPS_ECOLI	INHIBITOR	IC50	5.60	CHEMBL	CHEMBL
Endothelin-1 receptor	GPCR		EDNRA_RAT		IC50	4.16	CHEMBL
Transcriptional activator protein LasR	Unclassified		LASR_PSEAE		IC50	5.05	CHEMBL

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External reference:

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ID	Source
YTZ	PDB_CHEM_ID
002815	NDDF
10193	RXNORM
12699	IUPHAR_LIGAND_ID
16867004	SNOMEDCT_US
387093005	SNOMEDCT_US
4018558	VUID
4018558	VANDF
428	INN_ID
5340	PUBCHEM_CID

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Pharmaceutical products:

None