sulfasalazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
phenylazosalicylic acid derivatives antibacterial 2525 599-79-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • salazosulfapyridine
  • salicylazosulfapyridine
  • sulphasalazine
  • azulfidine
  • sulfasalazine
A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
  • Molecular weight: 398.39
  • Formula: C18H14N4O5S
  • CLOGP: 4
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 3
  • TPSA: 141.31
  • ALOGS: -3.93
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2 g O
2 g R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.00 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 167.34 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 15 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.11 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.26 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.00 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 7.60 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
June 20, 1950 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 4889.62 13.85 11472 230587 807861 49555204
Drug intolerance 4271.47 13.85 5236 236823 213868 50149197
Contraindicated product administered 3076.40 13.85 3670 238389 145288 50217777
Treatment failure 2856.05 13.85 3400 238659 134237 50228828
Joint swelling 2439.32 13.85 4270 237789 241016 50122049
Synovitis 2290.02 13.85 2888 239171 120977 50242088
Systemic lupus erythematosus 1930.11 13.85 2838 239221 137784 50225281
Pemphigus 1902.84 13.85 2597 239462 117569 50245496
Hand deformity 1760.43 13.85 2279 239780 97920 50265145
Glossodynia 1756.45 13.85 2449 239610 113120 50249945
Arthropathy 1717.82 13.85 2864 239195 155042 50208023
Therapeutic product effect decreased 1604.54 13.85 2560 239499 133490 50229575
Abdominal discomfort 1594.86 13.85 3456 238603 228185 50134880
Alopecia 1340.44 13.85 3341 238718 241706 50121359
Swelling 1295.63 13.85 2921 239138 197951 50165114
Wound 1292.51 13.85 2024 240035 103770 50259295
Anti-cyclic citrullinated peptide antibody positive 1188.28 13.85 1573 240486 69014 50294051
Musculoskeletal stiffness 1185.93 13.85 2169 239890 126312 50236753
Rheumatoid arthritis 1145.22 13.85 2798 239261 199752 50163313
Pericarditis 1070.30 13.85 1583 240476 77106 50285959
Rheumatoid factor positive 1062.98 13.85 1251 240808 48608 50314457
Therapeutic product effect incomplete 1033.93 13.85 1690 240369 89825 50273240
Death 1011.72 13.85 171 241888 325208 50037857
Discomfort 979.96 13.85 1814 240245 106566 50256499
Pain 976.65 13.85 5380 236679 573523 49789542
Hepatic enzyme increased 952.64 13.85 2058 240001 135322 50227743
C-reactive protein abnormal 907.43 13.85 875 241184 26934 50336131
Drug hypersensitivity 902.56 13.85 2943 239116 248067 50114998
Arthralgia 835.41 13.85 4219 237840 434483 49928582
Infusion related reaction 814.43 13.85 2204 239855 167353 50195712
Loss of personal independence in daily activities 760.41 13.85 1271 240788 68779 50294286
Product use issue 756.14 13.85 1981 240078 147494 50215571
Condition aggravated 662.77 13.85 2993 239066 294065 50069000
Hypersensitivity 656.68 13.85 2390 239669 212771 50150294
Duodenal ulcer perforation 642.00 13.85 933 241126 44678 50318387
Psoriatic arthropathy 608.78 13.85 925 241134 46107 50316958
Helicobacter infection 595.12 13.85 943 241116 48759 50314306
Acute kidney injury 590.08 13.85 179 241880 227879 50135186
Completed suicide 584.42 13.85 9 242050 131880 50231185
Anaemia 581.74 13.85 240 241819 252216 50110849
Red blood cell sedimentation rate increased 578.96 13.85 709 241350 28707 50334358
Rash 541.26 13.85 3759 238300 433712 49929353
Maternal exposure during pregnancy 536.26 13.85 1832 240227 157946 50205119
Hypotension 531.01 13.85 231 241828 235238 50127827
Red blood cell sedimentation rate abnormal 515.69 13.85 505 241554 15838 50347227
C-reactive protein increased 512.67 13.85 1041 241018 65433 50297632
Toxicity to various agents 489.43 13.85 202 241857 212297 50150768
Constipation 478.00 13.85 147 241912 185561 50177504
Drug interaction 460.92 13.85 189 241870 199432 50163633
Dyspnoea 445.56 13.85 1254 240805 546354 49816711
Sleep disorder due to general medical condition, insomnia type 443.47 13.85 644 241415 30803 50332262
Dehydration 427.39 13.85 102 241957 152347 50210718
Bone erosion 421.78 13.85 389 241670 11298 50351767
Asthenia 415.73 13.85 551 241508 318491 50044574
Fall 385.10 13.85 631 241428 334301 50028764
Seizure 358.92 13.85 65 241994 117809 50245256
Blood iron abnormal 355.60 13.85 213 241846 3113 50359952
Thrombocytopenia 347.02 13.85 91 241968 127582 50235483
Anxiety 342.72 13.85 213 241846 177393 50185672
Tremor 331.74 13.85 72 241987 114831 50248234
Febrile neutropenia 329.24 13.85 40 242019 97627 50265438
Dizziness 321.29 13.85 741 241318 345628 50017437
Product dose omission issue 319.54 13.85 247 241812 183591 50179474
Peripheral swelling 316.64 13.85 1872 240187 204064 50159001
Knee arthroplasty 315.89 13.85 594 241465 35252 50327813
Rheumatoid nodule 305.69 13.85 340 241719 12395 50350670
Disability 304.82 13.85 340 241719 12435 50350630
Inflammation 304.39 13.85 771 241288 56141 50306924
Cardiac arrest 297.95 13.85 28 242031 83623 50279442
Mobility decreased 292.99 13.85 945 241114 79003 50284062
Infection 291.22 13.85 1611 240448 171343 50191722
Diarrhoea 288.52 13.85 1646 240413 586830 49776235
Hyponatraemia 286.29 13.85 56 242003 96083 50266982
Malignant neoplasm progression 281.22 13.85 10 242049 68114 50294951
Intentional overdose 277.90 13.85 4 242055 62500 50300565
Oedema peripheral 277.31 13.85 210 241849 157751 50205314
Hip arthroplasty 274.05 13.85 509 241550 29920 50333145
Neutropenia 267.14 13.85 191 241868 147774 50215291
Somnolence 264.52 13.85 212 241847 154773 50208292
Grip strength decreased 262.81 13.85 307 241752 11814 50351251
Atrial fibrillation 258.98 13.85 82 241977 101663 50261402
Tachycardia 258.25 13.85 78 241981 99685 50263380
Drug abuse 257.23 13.85 6 242053 59840 50303225
Blood parathyroid hormone decreased 255.16 13.85 236 241823 6878 50356187
Granuloma skin 252.48 13.85 215 241844 5603 50357462
Cardiac failure congestive 247.38 13.85 51 242008 84331 50278734
Panniculitis 246.56 13.85 251 241808 8252 50354813
Urinary tract infection 246.14 13.85 434 241625 223586 50139479
Platelet count decreased 236.14 13.85 93 241966 100633 50262432
Rheumatic fever 232.78 13.85 342 241717 16525 50346540
Swollen joint count increased 232.44 13.85 320 241739 14553 50348512
Balance disorder 225.79 13.85 34 242025 70556 50292509
Bradycardia 220.54 13.85 25 242034 64401 50298664
Cardio-respiratory arrest 218.72 13.85 9 242050 53883 50309182
Gastrointestinal haemorrhage 217.66 13.85 43 242016 73278 50289787
Osteoarthritis 216.14 13.85 771 241288 67835 50295230
Muscle injury 215.57 13.85 519 241540 36592 50326473
Drug tolerance decreased 215.47 13.85 242 241817 8918 50354147
Hypokalaemia 211.65 13.85 78 241981 87914 50275151
Hyperkalaemia 209.92 13.85 4 242055 48085 50314980
Renal failure 209.59 13.85 125 241934 106508 50256557
Electrocardiogram QT prolonged 209.45 13.85 9 242050 51877 50311188
Respiratory failure 209.15 13.85 87 241972 91094 50271971
Pulmonary embolism 208.81 13.85 113 241946 101591 50261474
Gastrointestinal disorder 206.88 13.85 948 241111 93508 50269557
Irritable bowel syndrome 205.84 13.85 627 241432 50814 50312251
Cerebrovascular accident 205.14 13.85 98 241961 94582 50268483
Folliculitis 205.13 13.85 527 241532 38698 50324367
Overdose 201.56 13.85 113 241946 99614 50263451
Disease progression 199.03 13.85 105 241954 95761 50267304
Transplant dysfunction 196.96 13.85 170 241889 4514 50358551
Chest pain 193.01 13.85 344 241715 176538 50186527
Deformity 188.87 13.85 211 241848 7729 50355336
Hypoglycaemia 187.97 13.85 19 242040 53562 50309503
Depressed level of consciousness 186.02 13.85 17 242042 51936 50311129
Decreased appetite 185.82 13.85 430 241629 200493 50162572
Ankylosing spondylitis 185.36 13.85 199 241860 6966 50356099
Joint stiffness 184.84 13.85 432 241627 29876 50333189
Vision blurred 182.05 13.85 74 241985 78573 50284492
Multiple sclerosis relapse 182.01 13.85 5 242054 42959 50320106
Suicide attempt 177.25 13.85 20 242039 51712 50311353
Paraesthesia 177.25 13.85 188 241871 120055 50243010
Muscle spasms 174.46 13.85 206 241853 125347 50237718
Vomiting 171.84 13.85 1396 240663 459362 49903703
Chest discomfort 170.83 13.85 117 241942 92605 50270460
Joint destruction 170.51 13.85 145 241914 3771 50359294
Arthritis 169.29 13.85 842 241217 85879 50277186
Dysphagia 168.28 13.85 80 241979 77438 50285627
Agitation 167.80 13.85 27 242032 53357 50309708
Skin necrosis 167.09 13.85 232 241827 10635 50352430
Sepsis 166.25 13.85 236 241823 132689 50230376
Cardiac failure 165.80 13.85 78 241981 75962 50287103
Coma 165.41 13.85 35 242024 56844 50306221
Syncope 162.18 13.85 152 241907 102850 50260215
Cognitive disorder 161.90 13.85 13 242046 44110 50318955
Blister 158.76 13.85 818 241241 84600 50278465
Fluid retention 158.34 13.85 26 242033 50623 50312442
Hypoxia 155.95 13.85 28 242031 51095 50311970
Musculoskeletal deformity 154.67 13.85 81 241978 897 50362168
Myalgia 154.20 13.85 222 241837 124097 50238968
Epistaxis 153.27 13.85 57 242002 63897 50299168
Enthesopathy 152.30 13.85 180 241879 7013 50356052
International normalised ratio increased 152.16 13.85 15 242044 43137 50319928
White blood cell count decreased 149.19 13.85 204 241855 116518 50246547
Rhabdomyolysis 147.47 13.85 10 242049 39017 50324048
Abdominal pain 146.33 13.85 607 241452 235621 50127444
Wrong technique in product usage process 146.18 13.85 42 242017 55468 50307597
Cough 145.71 13.85 626 241433 240638 50122427
Impaired healing 142.20 13.85 686 241373 69100 50293965
Musculoskeletal pain 140.99 13.85 701 241358 71476 50291589
Mental status changes 140.94 13.85 8 242051 36264 50326801
Lactic acidosis 140.85 13.85 4 242055 33351 50329714
Dysarthria 140.13 13.85 10 242049 37393 50325672
Drug eruption 138.00 13.85 331 241728 23275 50339790
Fatigue 135.88 13.85 4380 237679 703221 49659844
Blood glucose increased 135.42 13.85 87 241972 71237 50291828
Haemoglobin decreased 134.61 13.85 252 241807 126964 50236101
Disorientation 134.35 13.85 9 242050 35475 50327590
Hallucination 133.05 13.85 30 242029 46627 50316438
Metabolic acidosis 133.03 13.85 15 242044 38810 50324255
Hyperglycaemia 130.09 13.85 12 242047 36393 50326672
Type 2 diabetes mellitus 130.08 13.85 411 241648 33964 50329101
Multiple organ dysfunction syndrome 129.06 13.85 40 242019 50297 50312768
Pulmonary oedema 128.91 13.85 37 242022 48901 50314164
Unresponsive to stimuli 128.05 13.85 4 242055 30605 50332460
Foot deformity 127.31 13.85 283 241776 18927 50344138
Blood cholesterol increased 126.68 13.85 562 241497 54653 50308412
Polyarthritis 126.03 13.85 172 241887 7755 50355310
Musculoskeletal disorder 125.74 13.85 265 241794 17084 50345981
Tenosynovitis 125.71 13.85 200 241859 10365 50352700
Neoplasm progression 124.99 13.85 3 242056 29154 50333911
Adverse event 124.51 13.85 476 241583 43287 50319778
Liver function test increased 122.64 13.85 333 241726 25273 50337792
Breast cancer stage III 122.59 13.85 111 241948 3145 50359920
Hyperhidrosis 121.78 13.85 149 241910 89277 50273788
Encephalopathy 120.76 13.85 11 242048 33700 50329365
Ill-defined disorder 119.93 13.85 549 241510 54105 50308960
Ulcer 117.82 13.85 283 241776 19917 50343148
Body height below normal 116.65 13.85 87 241972 1862 50361203
Weight decreased 115.97 13.85 604 241455 220641 50142424
Respiratory arrest 115.44 13.85 7 242052 30002 50333063
Red blood cell sedimentation rate 115.32 13.85 112 241947 3474 50359591
Physical disability 114.03 13.85 84 241975 1763 50361302
Intentional product use issue 113.29 13.85 692 241367 76226 50286839
Dysgeusia 113.04 13.85 24 242035 38892 50324173
Sedation 112.35 13.85 9 242050 30601 50332464
Human antichimeric antibody positive 111.06 13.85 76 241983 1413 50361652
Product quality issue 110.72 13.85 10 242049 30848 50332217
Neutrophil count decreased 110.31 13.85 41 242018 45985 50317080
Haemorrhage 110.20 13.85 59 242000 53382 50309683
Gastrooesophageal reflux disease 109.81 13.85 122 241937 76306 50286759
Seronegative arthritis 107.99 13.85 85 241974 1976 50361089
Hypervolaemia 107.88 13.85 3 242056 25496 50337569
Pulmonary hypertension 104.79 13.85 17 242042 33400 50329665
Asthma 104.50 13.85 166 241893 89171 50273894
Chronic obstructive pulmonary disease 104.44 13.85 63 241996 53372 50309693
Acute respiratory failure 104.16 13.85 9 242050 28773 50334292
Respiratory distress 103.90 13.85 12 242047 30477 50332588
Plasma cell myeloma 102.68 13.85 14 242045 31308 50331757
Feeling abnormal 102.44 13.85 286 241773 125206 50237859
Injection site pain 102.22 13.85 238 241821 110786 50252279
Flushing 101.85 13.85 102 241957 66913 50296152
Blood potassium decreased 100.94 13.85 26 242033 36919 50326146
Sciatica 100.33 13.85 276 241783 21106 50341959
Pancytopenia 100.33 13.85 154 241905 83876 50279189
Chills 100.09 13.85 194 241865 96493 50266572
Hepatic failure 97.77 13.85 18 242041 32265 50330800
Dyskinesia 97.40 13.85 10 242049 27851 50335214
Myocardial infarction 97.14 13.85 173 241886 88854 50274211
Transplant rejection 97.04 13.85 169 241890 9440 50353625
Drug withdrawal syndrome 96.02 13.85 6 242053 25075 50337990
Adverse drug reaction 95.82 13.85 519 241540 54703 50308362
Pleural effusion 95.61 13.85 151 241908 81303 50281762
Basal cell carcinoma 95.57 13.85 287 241772 23069 50339996
X-ray abnormal 95.14 13.85 88 241971 2564 50360501
Irritability 94.87 13.85 12 242047 28414 50334651
Serotonin syndrome 94.35 13.85 6 242053 24707 50338358
Lethargy 94.23 13.85 60 241999 49372 50313693
Onychomycosis 93.49 13.85 118 241941 4924 50358141
Hospitalisation 92.69 13.85 113 241946 67824 50295241
Blood pressure decreased 92.17 13.85 79 241980 55830 50307235
Pneumonia 92.07 13.85 1266 240793 377135 49985930
Hypophagia 91.83 13.85 12 242047 27716 50335349
Depression 91.55 13.85 443 241616 164980 50198085
Intentional product misuse 91.48 13.85 55 242004 46679 50316386
COVID-19 91.22 13.85 55 242004 46607 50316458
Restlessness 90.74 13.85 8 242051 25165 50337900
Pyrexia 90.37 13.85 1278 240781 378925 49984140
Pneumonia aspiration 90.29 13.85 19 242040 30985 50332080
Dry skin 90.06 13.85 47 242012 43144 50319921
Wheelchair user 90.04 13.85 115 241944 4857 50358208
Therapeutic response decreased 89.58 13.85 455 241604 46776 50316289
Transient ischaemic attack 89.29 13.85 22 242037 32188 50330877
Dislocation of vertebra 89.26 13.85 91 241968 2996 50360069
Back pain 89.07 13.85 651 241408 219379 50143686
Disturbance in attention 89.02 13.85 20 242039 31166 50331899
Joint range of motion decreased 88.90 13.85 241 241818 18271 50344794
Memory impairment 87.68 13.85 153 241906 79207 50283858
Dyspnoea exertional 87.41 13.85 70 241989 51163 50311902
Skin ulcer 85.98 13.85 366 241693 34952 50328113
Blood bilirubin increased 84.79 13.85 24 242035 32014 50331051
Ovarian cyst 84.77 13.85 199 241860 13797 50349268
Hypomagnesaemia 84.45 13.85 7 242052 23149 50339916
Cerebral haemorrhage 84.29 13.85 14 242045 27038 50336027
Haematoma 84.26 13.85 21 242038 30489 50332576
Ascites 84.18 13.85 33 242026 35828 50327237
Dysuria 83.98 13.85 17 242042 28487 50334578
Aphasia 83.94 13.85 17 242042 28477 50334588
Deep vein thrombosis 83.11 13.85 139 241920 73165 50289900
Muscular weakness 81.70 13.85 211 241848 94802 50268263
Antibody test positive 81.59 13.85 76 241983 2235 50360830
Lower respiratory tract infection 81.28 13.85 753 241306 94448 50268617
Chronic kidney disease 80.41 13.85 45 242014 39726 50323339
Accidental overdose 80.13 13.85 3 242056 19530 50343535
Vascular access complication 80.07 13.85 56 242003 1080 50361985
Bone pain 79.99 13.85 65 241994 47164 50315901
Red cell distribution width decreased 79.12 13.85 55 242004 1050 50362015
Generalised tonic-clonic seizure 78.97 13.85 15 242044 26295 50336770
Fear of injection 78.84 13.85 120 241939 5983 50357082
Joint effusion 78.72 13.85 185 241874 12836 50350229
Urinary incontinence 78.71 13.85 19 242040 28189 50334876
Stomatitis 78.34 13.85 785 241274 100559 50262506
Orthostatic hypotension 78.17 13.85 22 242037 29459 50333606
Full blood count decreased 78.17 13.85 8 242051 22338 50340727
Osteonecrosis of jaw 77.90 13.85 29 242030 32497 50330568
Abdominal distension 77.44 13.85 144 241915 72759 50290306
Finger deformity 76.64 13.85 114 241945 5568 50357497
Neuropathy peripheral 76.38 13.85 224 241835 96533 50266532
General physical health deterioration 76.02 13.85 1027 241032 141407 50221658
Nausea 75.56 13.85 2690 239369 702708 49660357
Aggression 75.34 13.85 7 242052 21109 50341956
Arrhythmia 75.32 13.85 32 242027 33100 50329965
Device dislocation 74.63 13.85 8 242051 21538 50341527
Blood pressure increased 74.53 13.85 355 241704 132777 50230288
Pulmonary arterial hypertension 74.50 13.85 6 242053 20313 50342752
Urinary retention 74.35 13.85 17 242042 26173 50336892
Blood urea increased 73.95 13.85 12 242047 23573 50339492
Melaena 73.21 13.85 19 242040 26845 50336220
Blood creatine phosphokinase increased 73.10 13.85 18 242041 26349 50336716
Ejection fraction decreased 72.21 13.85 4 242055 18516 50344549
Injection site erythema 71.92 13.85 157 241902 74779 50288286
Altered state of consciousness 71.33 13.85 10 242049 21900 50341165
Nail disorder 71.17 13.85 149 241910 9559 50353506
Exostosis 70.92 13.85 166 241893 11487 50351578
Rheumatoid factor negative 70.90 13.85 41 242018 559 50362506
Fibromyalgia 70.26 13.85 411 241648 44567 50318498
Upper respiratory tract infection 70.14 13.85 130 241929 65768 50297297
Hip fracture 69.41 13.85 19 242040 25912 50337153
Lymphocyte count decreased 69.07 13.85 20 242039 26287 50336778
Hypercalcaemia 68.06 13.85 256 241803 23096 50339969
Blood sodium decreased 68.03 13.85 10 242049 21137 50341928
Mean platelet volume decreased 67.83 13.85 59 242000 1583 50361482
Vaginal haemorrhage 67.60 13.85 17 242042 24534 50338531
Tenderness 67.52 13.85 219 241840 18346 50344719
Coronary artery disease 67.11 13.85 29 242030 29697 50333368
Metastases to bone 66.86 13.85 5 242054 17990 50345075
Haematuria 66.29 13.85 20 242039 25593 50337472
Infusion site reaction 65.56 13.85 66 241993 2140 50360925
Product label confusion 65.31 13.85 37 242022 484 50362581
Presbyacusis 64.70 13.85 73 241986 2703 50360362
Foetal exposure during pregnancy 64.51 13.85 25 242034 27334 50335731
Throat irritation 64.40 13.85 32 242027 30207 50332858
Psychotic disorder 64.28 13.85 13 242046 21799 50341266
Cellulitis 64.16 13.85 153 241906 70645 50292420
Rectal haemorrhage 64.14 13.85 54 242005 38504 50324561
Pleural thickening 63.42 13.85 70 241989 2529 50360536
Epilepsy 63.25 13.85 13 242046 21554 50341511
Emotional distress 63.08 13.85 29 242030 28634 50334431
Abortion spontaneous 62.98 13.85 64 241995 41708 50321357
Impaired work ability 62.93 13.85 175 241884 13465 50349600
Skin exfoliation 62.43 13.85 42 242017 33570 50329495
Sinus tachycardia 62.36 13.85 13 242046 21341 50341724
International normalised ratio fluctuation 62.31 13.85 64 241995 2126 50360939
Acute myocardial infarction 62.30 13.85 31 242028 29242 50333823
Obstructive airways disorder 62.23 13.85 3 242056 15649 50347416
Pallor 62.09 13.85 17 242042 23182 50339883
Accidental exposure to product 61.52 13.85 17 242042 23040 50340025
Coeliac disease 61.01 13.85 131 241928 8554 50354511
Nervousness 60.81 13.85 28 242031 27623 50335442
Device issue 60.77 13.85 11 242048 19961 50343104
Electrolyte imbalance 60.44 13.85 6 242053 17163 50345902
Clostridium difficile colitis 60.41 13.85 7 242052 17735 50345330
Palpitations 60.19 13.85 240 241819 94266 50268799
Drug level increased 59.97 13.85 10 242049 19258 50343807
Head injury 59.95 13.85 20 242039 24000 50339065
Incorrect dose administered 59.45 13.85 87 241972 48327 50314738
Therapy cessation 59.32 13.85 25 242034 25986 50337079
Cardiac disorder 58.08 13.85 72 241987 42907 50320158
Interstitial lung disease 57.78 13.85 444 241615 52732 50310333
Diplopia 57.76 13.85 11 242048 19249 50343816
Ischaemic stroke 57.67 13.85 5 242054 15943 50347122
Bone density abnormal 57.63 13.85 72 241987 2973 50360092
Withdrawal syndrome 57.33 13.85 8 242051 17582 50345483
Ventricular tachycardia 57.10 13.85 5 242054 15816 50347249
Pleural fibrosis 56.19 13.85 75 241984 3309 50359756
Depressed mood 56.16 13.85 48 242011 33975 50329090
Dactylitis 55.90 13.85 56 242003 1805 50361260
Pollakiuria 55.89 13.85 22 242037 23829 50339236
Insomnia 55.61 13.85 551 241508 174314 50188751
Muscle twitching 55.36 13.85 5 242054 15426 50347639
Right ventricular failure 54.80 13.85 6 242053 15887 50347178
Bone marrow failure 54.78 13.85 32 242027 27592 50335473
Mycotic allergy 54.55 13.85 39 242020 780 50362285
Vertigo 54.50 13.85 103 241956 51729 50311336
Adverse reaction 54.11 13.85 124 241935 8462 50354603
White blood cell count abnormal 54.05 13.85 95 241964 5345 50357720
Arthrodesis 53.96 13.85 63 241996 2422 50360643
Oxygen saturation decreased 53.95 13.85 175 241884 73073 50289992
Myoclonus 53.82 13.85 4 242055 14466 50348599
Product administration error 53.55 13.85 14 242045 19685 50343380
Confusional state 53.39 13.85 600 241459 185328 50177737
Jaundice 53.29 13.85 30 242029 26399 50336666
Acne 53.16 13.85 210 241849 19385 50343680
Hypoaesthesia 53.14 13.85 373 241686 126884 50236181
Drug specific antibody 53.14 13.85 54 242005 1771 50361294
Cholelithiasis 53.02 13.85 62 241997 37911 50325154
Upper gastrointestinal haemorrhage 52.95 13.85 7 242052 16028 50347037
Mean cell volume decreased 52.72 13.85 64 241995 2565 50360500
Blood alkaline phosphatase increased 52.69 13.85 61 241998 37465 50325600
Hot flush 52.65 13.85 81 241978 44088 50318977
Pancreatitis acute 52.54 13.85 24 242035 23788 50339277
Coagulopathy 52.24 13.85 11 242048 17933 50345132
Urticaria 52.05 13.85 384 241675 129177 50233888
Status epilepticus 51.95 13.85 3 242056 13403 50349662
Speech disorder 51.87 13.85 56 242003 35492 50327573
Premature baby 51.85 13.85 12 242047 18325 50344740
Dermatitis allergic 51.74 13.85 156 241903 12564 50350501
Visual acuity reduced 51.62 13.85 16 242043 20123 50342942
Neck deformity 51.27 13.85 55 242004 1923 50361142
Loss of consciousness 51.22 13.85 291 241768 104062 50259003
Angina pectoris 50.99 13.85 31 242028 26157 50336908
Sinus bradycardia 50.93 13.85 3 242056 13180 50349885
Drug ineffective for unapproved indication 50.92 13.85 19 242040 21262 50341803
Premature delivery 50.45 13.85 25 242034 23638 50339427
Mental disorder 50.37 13.85 21 242038 21970 50341095
Pulmonary fibrosis 50.30 13.85 241 241818 24196 50338869
Swollen tongue 50.25 13.85 38 242021 28592 50334473
Wrist deformity 49.91 13.85 52 242007 1757 50361308
Blood magnesium increased 49.63 13.85 65 241994 2815 50360250
Pulmonary congestion 49.54 13.85 7 242052 15240 50347825
Fine motor skill dysfunction 49.26 13.85 78 241981 4025 50359040
Onychomadesis 49.22 13.85 72 241987 3464 50359601
Bone swelling 49.03 13.85 43 242016 1167 50361898
Headache 48.86 13.85 1955 240104 504580 49858485
Oral discomfort 48.56 13.85 114 241945 7903 50355162
Shock 48.47 13.85 19 242040 20631 50342434
Lacrimation increased 48.29 13.85 11 242048 16981 50346084
Posterior reversible encephalopathy syndrome 48.16 13.85 7 242052 14921 50348144
Bloody discharge 48.13 13.85 42 242017 1132 50361933
Retinitis 48.09 13.85 52 242007 1835 50361230
Extremity contracture 47.88 13.85 43 242016 1205 50361860
Hepatocellular injury 47.42 13.85 33 242026 25914 50337151
Therapy non-responder 47.33 13.85 411 241648 50611 50312454
Device related infection 47.17 13.85 20 242039 20715 50342350
Hallucination, visual 46.60 13.85 11 242048 16571 50346494
Ovarian neoplasm 46.51 13.85 36 242023 816 50362249
Liver injury 46.35 13.85 238 241821 24568 50338497
Anti-cyclic citrullinated peptide antibody 46.16 13.85 47 242012 1545 50361520
Neoplasm malignant 46.04 13.85 230 241829 23485 50339580
Throat tightness 46.02 13.85 21 242038 20826 50342239
Blood glucose decreased 45.73 13.85 15 242044 18196 50344869
Blindness 45.57 13.85 13 242046 17256 50345809
Sleep apnoea syndrome 45.44 13.85 29 242030 23839 50339226
Abdominal pain upper 45.37 13.85 515 241544 158794 50204271
Suicidal ideation 45.33 13.85 126 241933 55259 50307806
Hyperlipidaemia 44.64 13.85 14 242045 17476 50345589
Flatulence 44.56 13.85 45 242014 29413 50333652
Cardiogenic shock 44.53 13.85 10 242049 15589 50347476
Alanine aminotransferase abnormal 44.47 13.85 75 241984 4081 50358984
Haemorrhage intracranial 44.42 13.85 4 242055 12370 50350695
Tachypnoea 44.41 13.85 8 242051 14569 50348496
Hepatitis 44.41 13.85 280 241779 31173 50331892
Product substitution issue 44.41 13.85 7 242052 14050 50349015
Circulatory collapse 44.38 13.85 20 242039 19980 50343085
Back injury 44.29 13.85 102 241957 6983 50356082
Retching 43.98 13.85 5 242054 12857 50350208
Live birth 43.83 13.85 175 241884 16233 50346832
Feeling hot 43.81 13.85 75 241984 39127 50323938
Pericardial effusion 43.60 13.85 35 242024 25554 50337511
Ataxia 43.25 13.85 7 242052 13779 50349286
Spinal stenosis 43.25 13.85 153 241906 13397 50349668
Progressive multifocal leukoencephalopathy 43.09 13.85 3 242056 11454 50351611
Cyanosis 42.81 13.85 10 242049 15174 50347891
Colitis 42.80 13.85 74 241985 38455 50324610
Surgery 42.51 13.85 49 242010 30156 50332909
Drug dependence 41.94 13.85 21 242038 19738 50343327
Therapy interrupted 41.90 13.85 22 242037 20130 50342935
Restless legs syndrome 41.89 13.85 12 242047 15885 50347180
Extrapyramidal disorder 41.73 13.85 4 242055 11766 50351299
Cholestasis 41.73 13.85 36 242023 25365 50337700
Infusion site pain 41.72 13.85 5 242054 12341 50350724
Bacteraemia 41.71 13.85 9 242050 14424 50348641
Hemiparesis 41.52 13.85 22 242037 20026 50343039
Hypersomnia 41.40 13.85 11 242048 15303 50347762
Deafness neurosensory 41.40 13.85 76 241983 4425 50358640
Mitral valve incompetence 41.13 13.85 16 242043 17455 50345610
Myelodysplastic syndrome 40.66 13.85 11 242048 15121 50347944
Haemoptysis 39.91 13.85 38 242021 25535 50337530
Dystonia 39.88 13.85 5 242054 11921 50351144
Thyroid neoplasm 39.82 13.85 65 241994 3442 50359623
Synovial fluid analysis 39.76 13.85 44 242015 1594 50361471
Gamma-glutamyltransferase increased 39.63 13.85 50 242009 29573 50333492
Pain in extremity 39.45 13.85 1638 240421 271227 50091838
Osteonecrosis 39.37 13.85 30 242029 22487 50340578
Off label use 39.24 13.85 2702 239357 471724 49891341
Tinnitus 39.20 13.85 46 242013 28086 50334979
Product prescribing error 39.18 13.85 26 242033 20935 50342130
Blood magnesium decreased 39.02 13.85 4 242055 11156 50351909
Staphylococcal infection 39.02 13.85 69 241990 35547 50327518
Haematemesis 39.00 13.85 45 242014 27680 50335385
Bone density decreased 38.80 13.85 129 241930 10946 50352119
Labelled drug-drug interaction medication error 38.67 13.85 3 242056 10474 50352591
Coordination abnormal 38.17 13.85 5 242054 11529 50351536
Rash erythematous 37.75 13.85 68 241991 34784 50328281
Acute hepatic failure 37.50 13.85 14 242045 15663 50347402
Cerebral infarction 37.50 13.85 29 242030 21575 50341490
Full blood count abnormal 37.39 13.85 34 242025 23354 50339711
Small intestinal obstruction 37.36 13.85 15 242044 16053 50347012
Heart rate increased 37.05 13.85 217 241842 77033 50286032
Mean cell haemoglobin decreased 36.94 13.85 61 241998 3262 50359803
Muscle spasticity 36.87 13.85 18 242041 17166 50345899
Cytomegalovirus infection 36.77 13.85 20 242039 17942 50345123
Cystitis 36.75 13.85 101 241958 44463 50318602
Nodule 36.68 13.85 170 241889 16833 50346232
Oropharyngeal pain 36.55 13.85 220 241839 77581 50285484
Malaise 36.28 13.85 1277 240782 334255 50028810
Tuberculin test positive 36.11 13.85 59 242000 3127 50359938
Lip swelling 36.05 13.85 39 242020 24697 50338368
Device difficult to use 36.02 13.85 3 242056 9883 50353182
Liver function test abnormal 35.96 13.85 347 241712 43992 50319073
No adverse event 35.94 13.85 66 241993 33512 50329553
Nightmare 35.82 13.85 16 242043 16070 50346995
Sinus disorder 35.73 13.85 22 242037 18436 50344629
Respiratory depression 35.72 13.85 7 242052 12003 50351062
Mania 35.49 13.85 5 242054 10911 50352154
Angioedema 35.27 13.85 80 241979 37596 50325469
Brain oedema 35.17 13.85 8 242051 12362 50350703
Acute myeloid leukaemia 35.16 13.85 14 242045 15060 50348005
Diabetic ketoacidosis 35.02 13.85 21 242038 17851 50345214
Eye swelling 35.02 13.85 27 242032 20117 50342948
Tenosynovitis stenosans 34.97 13.85 48 242011 2176 50360889
Panic attack 34.82 13.85 25 242034 19317 50343748
Metastases to central nervous system 34.79 13.85 6 242053 11276 50351789
Peptic ulcer haemorrhage 34.72 13.85 33 242026 996 50362069
Malnutrition 34.67 13.85 10 242049 13179 50349886
Presyncope 34.33 13.85 39 242020 24159 50338906
Hypovolaemia 34.14 13.85 3 242056 9462 50353603
Joint injury 33.95 13.85 199 241860 21590 50341475
Incontinence 33.85 13.85 4 242055 9981 50353084
Device malfunction 33.74 13.85 15 242044 15106 50347959
Metastases to liver 33.63 13.85 28 242031 20076 50342989
Osteoporosis 33.39 13.85 345 241714 44534 50318531
Joint dislocation 33.32 13.85 132 241927 12201 50350864
Nervous system disorder 33.31 13.85 18 242041 16205 50346860
Aspiration 33.24 13.85 3 242056 9261 50353804
Abdominal pain lower 33.18 13.85 33 242026 21723 50341342
Therapeutic product effect variable 33.11 13.85 33 242026 1057 50362008
Tricuspid valve incompetence 32.99 13.85 10 242049 12760 50350305
Drug reaction with eosinophilia and systemic symptoms 32.94 13.85 241 241818 28183 50334882
Hepatic enzyme abnormal 32.76 13.85 72 241987 4777 50358288
Caesarean section 32.62 13.85 17 242042 15622 50347443
Hyperthyroidism 32.44 13.85 9 242050 12166 50350899
Arteriosclerosis 32.41 13.85 3 242056 9074 50353991
Femur fracture 32.34 13.85 83 241976 37381 50325684
Body temperature increased 32.31 13.85 63 241996 31278 50331787
Subdural haematoma 31.93 13.85 11 242048 12936 50350129
Mental impairment 31.91 13.85 9 242050 12035 50351030
Toxic epidermal necrolysis 31.83 13.85 32 242027 20960 50342105
Acute generalised exanthematous pustulosis 31.79 13.85 3 242056 8935 50354130
Central nervous system lesion 31.68 13.85 4 242055 9485 50353580
Intestinal sepsis 31.61 13.85 18 242041 238 50362827
Ventricular extrasystoles 31.55 13.85 6 242053 10510 50352555
Anal incontinence 31.55 13.85 8 242051 11482 50351583
Left ventricular dysfunction 31.51 13.85 6 242053 10500 50352565
Premature labour 31.49 13.85 8 242051 11468 50351597
Nasal congestion 31.17 13.85 132 241927 50988 50312077
Contusion 31.06 13.85 729 241330 111454 50251611
Dementia 31.06 13.85 19 242040 15978 50347087
Blood triglycerides increased 30.82 13.85 8 242051 11304 50351761
Swelling face 30.74 13.85 138 241921 52457 50310608
Psoriasis 30.63 13.85 482 241577 68518 50294547
Peritonitis 30.62 13.85 18 242041 15468 50347597
Subarachnoid haemorrhage 30.57 13.85 7 242052 10769 50352296
Dermatitis contact 30.49 13.85 3 242056 8643 50354422
Renal disorder 30.39 13.85 53 242006 27452 50335613
Scleritis 30.33 13.85 55 242004 3172 50359893
Haematochezia 30.26 13.85 94 241965 39788 50323277
Multiple sclerosis 30.21 13.85 32 242027 20461 50342604
Lymphoedema 30.08 13.85 4 242055 9118 50353947
Tuberculosis 29.76 13.85 111 241948 9972 50353093
Supraventricular tachycardia 29.68 13.85 12 242047 12789 50350276
Sudden death 29.51 13.85 4 242055 8987 50354078
Bone cyst 29.32 13.85 42 242017 1982 50361083
Sensory disturbance 29.26 13.85 10 242049 11819 50351246
Myelosuppression 29.24 13.85 14 242045 13503 50349562
Shock haemorrhagic 29.15 13.85 3 242056 8341 50354724
Kidney infection 29.09 13.85 28 242031 18718 50344347
Acute coronary syndrome 28.87 13.85 5 242054 9369 50353696
Breast cancer 28.79 13.85 323 241736 42567 50320498
Chromaturia 28.79 13.85 17 242042 14573 50348492
Lyme disease 28.70 13.85 47 242012 2496 50360569
Immobile 28.60 13.85 70 241989 4984 50358081
Injection site haemorrhage 28.58 13.85 36 242023 21310 50341755
Atrial flutter 28.52 13.85 4 242055 8759 50354306
Tongue disorder 28.50 13.85 103 241956 9113 50353952
Infusion site erythema 28.37 13.85 4 242055 8723 50354342
Lymphopenia 28.37 13.85 20 242039 15601 50347464
Acidosis 28.31 13.85 7 242052 10220 50352845
Leukocytosis 28.28 13.85 40 242019 22539 50340526
Mass excision 28.17 13.85 17 242042 252 50362813
Skin burning sensation 28.14 13.85 7 242052 10178 50352887
Renal impairment 28.14 13.85 229 241830 75432 50287633
Pustular psoriasis 27.91 13.85 60 241999 3921 50359144
Acute respiratory distress syndrome 27.82 13.85 36 242023 21063 50342002
Hepatotoxicity 27.73 13.85 224 241835 27002 50336063
Nasopharyngitis 27.59 13.85 1157 240902 191770 50171295
Pulmonary toxicity 27.29 13.85 73 241986 5489 50357576
Bronchitis 27.23 13.85 343 241716 103816 50259249
Thrombosis 27.22 13.85 156 241903 55677 50307388
Feeling cold 27.15 13.85 32 242027 19499 50343566
Stress cardiomyopathy 27.13 13.85 3 242056 7884 50355181
Erythema 27.10 13.85 515 241544 145899 50217166
Hypophosphataemia 27.01 13.85 4 242055 8410 50354655
Mucosal inflammation 26.79 13.85 100 241959 40042 50323023
Cartilage atrophy 26.66 13.85 14 242045 156 50362909
Hallucination, auditory 26.65 13.85 9 242050 10719 50352346
Eosinophilia 26.53 13.85 30 242029 18622 50344443
Monocyte count increased 26.48 13.85 72 241987 5467 50357598
Inappropriate antidiuretic hormone secretion 26.38 13.85 15 242044 13128 50349937
Limb injury 26.24 13.85 35 242024 20215 50342850
Viral infection 26.22 13.85 66 241993 29920 50333145
Gout 26.19 13.85 11 242048 11459 50351606
Drug tolerance 26.15 13.85 67 241992 4909 50358156
Metastases to lung 26.09 13.85 10 242049 11010 50352055
Hepatic encephalopathy 25.90 13.85 7 242052 9629 50353436
Anger 25.67 13.85 11 242048 11322 50351743
Heart rate irregular 25.56 13.85 33 242026 19327 50343738
Lung disorder 25.52 13.85 327 241732 44472 50318593
Uveitis 25.43 13.85 100 241959 9210 50353855
Obesity 25.36 13.85 152 241907 16623 50346442
Lipase increased 25.35 13.85 5 242054 8536 50354529
Haemodynamic instability 25.34 13.85 4 242055 8020 50355045
Paranoia 25.16 13.85 9 242050 10339 50352726
Amenorrhoea 25.12 13.85 5 242054 8479 50354586
Dialysis 25.10 13.85 7 242052 9431 50353634
Ageusia 25.05 13.85 12 242047 11571 50351494
Dental caries 25.00 13.85 8 242051 9859 50353206
Spinal meningioma benign 24.96 13.85 12 242047 109 50362956
Cholecystitis 24.87 13.85 18 242041 13853 50349212
Gastritis 24.84 13.85 78 241981 32905 50330160
Epigastric discomfort 24.83 13.85 73 241986 5797 50357268
Amnesia 24.62 13.85 111 241948 42149 50320916
Prothrombin time prolonged 24.56 13.85 6 242053 8832 50354233
Diverticulum 24.53 13.85 10 242049 10604 50352461
Hiatus hernia 24.50 13.85 31 242028 18313 50344752
Product storage error 24.46 13.85 14 242045 12210 50350855
Ecchymosis 24.46 13.85 9 242050 10160 50352905
Acute pulmonary oedema 24.41 13.85 3 242056 7264 50355801
Lupus-like syndrome 24.37 13.85 100 241959 9391 50353674
Thrombotic microangiopathy 24.37 13.85 6 242053 8785 50354280
Respiratory rate increased 24.31 13.85 12 242047 11373 50351692
Escherichia infection 24.18 13.85 11 242048 10930 50352135
Rib fracture 24.12 13.85 34 242025 19187 50343878
Klebsiella infection 24.09 13.85 3 242056 7191 50355874
Dysphonia 23.97 13.85 100 241959 38792 50324273
Faeces discoloured 23.97 13.85 25 242034 16099 50346966
Neck mass 23.96 13.85 51 242008 3310 50359755
Device breakage 23.73 13.85 8 242051 9539 50353526
Arteriosclerosis coronary artery 23.68 13.85 4 242055 7632 50355433
Anti-neutrophil cytoplasmic antibody positive vasculitis 23.66 13.85 41 242018 2281 50360784
Cardiac murmur 23.59 13.85 11 242048 10773 50352292
Breast cancer metastatic 23.57 13.85 10 242049 10354 50352711
Mycobacterium marinum infection 23.52 13.85 14 242045 202 50362863
Bedridden 23.51 13.85 98 241961 9269 50353796
Gait disturbance 23.38 13.85 908 241151 149097 50213968
Rash macular 23.31 13.85 35 242024 19242 50343823
Sinusitis 23.29 13.85 1018 241041 169540 50193525
Hypoalbuminaemia 23.26 13.85 9 242050 9851 50353214
Decubitus ulcer 23.23 13.85 8 242051 9410 50353655
Productive cough 23.20 13.85 152 241907 52542 50310523
Ankle arthroplasty 23.18 13.85 28 242031 1116 50361949
Oesophagitis 23.18 13.85 18 242041 13365 50349700
Apnoea 23.10 13.85 3 242056 6963 50356102
Paraesthesia oral 23.06 13.85 15 242044 12206 50350859
Iron deficiency anaemia 22.95 13.85 28 242031 16806 50346259
Lower limb fracture 22.77 13.85 131 241928 14115 50348950
Gingival bleeding 22.72 13.85 13 242046 11340 50351725
Incorrect product administration duration 22.66 13.85 8 242051 9267 50353798
Hemiplegia 22.60 13.85 4 242055 7377 50355688
Synovial cyst 22.54 13.85 88 241971 8078 50354987
Blood creatinine increased 22.53 13.85 244 241815 75916 50287149
Underdose 22.47 13.85 39 242020 20239 50342826
Sleep disorder 22.42 13.85 392 241667 56891 50306174
Diabetes mellitus inadequate control 22.37 13.85 18 242041 13127 50349938
Migraine 22.34 13.85 241 241818 75039 50288026
Oedema 22.34 13.85 221 241838 69960 50293105
Allergy to metals 22.22 13.85 19 242040 498 50362567
Gastroenteritis 22.14 13.85 49 242010 23232 50339833
Juvenile idiopathic arthritis 22.06 13.85 45 242014 2834 50360231
Sensory loss 22.01 13.85 5 242054 7733 50355332
Lung infiltration 21.97 13.85 19 242040 13374 50349691
Bursitis 21.94 13.85 181 241878 21954 50341111
Hypoaesthesia oral 21.88 13.85 12 242047 10716 50352349
Disseminated intravascular coagulation 21.82 13.85 30 242029 17105 50345960
Renal injury 21.79 13.85 7 242052 8604 50354461
Troponin increased 21.63 13.85 6 242053 8112 50354953
Sacroiliitis 21.59 13.85 42 242017 2555 50360510
Cold sweat 21.57 13.85 12 242047 10632 50352433
Polyuria 21.50 13.85 4 242055 7117 50355948
Faecaloma 21.44 13.85 4 242055 7104 50355961
Precancerous cells present 21.44 13.85 28 242031 1209 50361856
Effusion 21.39 13.85 32 242027 1571 50361494
Salt craving 21.37 13.85 10 242049 85 50362980
Pancreatitis 21.35 13.85 118 241941 42496 50320569
Blood urine present 21.31 13.85 18 242041 12815 50350250
Injection site swelling 21.30 13.85 115 241944 41658 50321407
Delirium 21.25 13.85 102 241957 38090 50324975
Ear pain 21.22 13.85 67 241992 28216 50334849
Thyroid disorder 21.21 13.85 118 241941 12559 50350506
Incorrect dosage administered 21.15 13.85 33 242026 1681 50361384
Neutrophil count increased 21.11 13.85 22 242037 14173 50348892
Metastases to lymph nodes 21.09 13.85 4 242055 7020 50356045
Coronary artery occlusion 21.04 13.85 5 242054 7498 50355567
COVID-19 pneumonia 20.93 13.85 7 242052 8388 50354677
Adrenal insufficiency 20.86 13.85 128 241931 14115 50348950
Injection site pruritus 20.74 13.85 111 241948 40300 50322765
Post procedural complication 20.72 13.85 25 242034 15079 50347986
Activated partial thromboplastin time prolonged 20.66 13.85 3 242056 6399 50356666
Stevens-Johnson syndrome 20.51 13.85 46 242013 21706 50341359
Lower gastrointestinal haemorrhage 20.48 13.85 4 242055 6875 50356190
Deafness 20.46 13.85 27 242032 15664 50347401
Sinus congestion 20.39 13.85 22 242037 13949 50349116
Anovulatory cycle 20.38 13.85 11 242048 130 50362935
Skin discolouration 20.33 13.85 84 241975 32673 50330392
Blood albumin decreased 20.27 13.85 20 242039 13216 50349849
Hypothyroidism 20.26 13.85 89 241970 34036 50329029
Tooth extraction 20.25 13.85 9 242050 9066 50353999
Colitis ischaemic 20.24 13.85 10 242049 9473 50353592
Gastric ulcer 20.13 13.85 45 242014 21260 50341805
Polyglandular disorder 20.13 13.85 7 242052 24 50363041
Abdominal tenderness 20.12 13.85 5 242054 7275 50355790
Inappropriate schedule of product administration 20.12 13.85 233 241826 71598 50291467
Foetal death 20.08 13.85 7 242052 8173 50354892
Post procedural haemorrhage 20.08 13.85 5 242054 7265 50355800
Rash maculo-papular 20.06 13.85 63 241996 26578 50336487
Skin irritation 20.05 13.85 6 242053 7721 50355344
Septic shock 19.93 13.85 176 241883 56999 50306066
Bundle branch block left 19.91 13.85 3 242056 6227 50356838
Stress at work 19.86 13.85 25 242034 1040 50362025
Neutropenic sepsis 19.85 13.85 23 242036 14124 50348941
Nocturia 19.85 13.85 4 242055 6726 50356339
Joint space narrowing 19.80 13.85 13 242046 225 50362840
Rhinitis allergic 19.79 13.85 5 242054 7195 50355870
Abortion induced 19.73 13.85 10 242049 9334 50353731
Infusion site swelling 19.70 13.85 5 242054 7171 50355894
Gallbladder disorder 19.67 13.85 31 242028 16711 50346354
Myocardial ischaemia 19.64 13.85 16 242043 11597 50351468
Gastrointestinal toxicity 19.63 13.85 58 242001 4619 50358446
Psychomotor hyperactivity 19.57 13.85 10 242049 9291 50353774
Eructation 19.47 13.85 5 242054 7116 50355949
Maternal exposure timing unspecified 19.29 13.85 49 242010 3571 50359494
Adjustment disorder with depressed mood 19.26 13.85 42 242017 2772 50360293
Cardiomegaly 19.23 13.85 29 242030 15916 50347149
Neuralgia 19.21 13.85 48 242011 21815 50341250
Spondyloarthropathy 19.20 13.85 21 242038 751 50362314
Demyelination 19.19 13.85 68 241991 5958 50357107
Ileus 19.12 13.85 21 242038 13208 50349857
Tendonitis 18.99 13.85 141 241918 16564 50346501
Injection site warmth 18.97 13.85 23 242036 13843 50349222
Peripheral coldness 18.89 13.85 13 242046 10270 50352795
Pulmonary haemorrhage 18.86 13.85 4 242055 6488 50356577
Exposure during pregnancy 18.77 13.85 438 241621 120577 50242488
Respiratory disorder 18.72 13.85 81 241978 31106 50331959
Respiratory tract infection 18.71 13.85 84 241975 31933 50331132
Weber tuning fork test abnormal 18.70 13.85 9 242050 82 50362983
Anaphylactic shock 18.70 13.85 43 242016 20112 50342953
Erythema multiforme 18.64 13.85 10 242049 9040 50354025
Medication error 18.62 13.85 99 241960 36005 50327060
Pseudomonas infection 18.59 13.85 11 242048 9419 50353646
Glomerular filtration rate decreased 18.55 13.85 17 242042 11635 50351430
Eye haemorrhage 18.49 13.85 6 242053 7329 50355736
Renal tubular necrosis 18.49 13.85 13 242046 10155 50352910
Skin laceration 18.46 13.85 39 242020 18803 50344262
Urticarial vasculitis 18.46 13.85 18 242041 561 50362504
Tooth disorder 18.45 13.85 57 242002 24171 50338894
Wound infection 18.31 13.85 110 241949 12038 50351027
Blood calcium increased 18.28 13.85 7 242052 7712 50355353
Haemorrhoids 18.20 13.85 40 242019 19013 50344052
Cardiomyopathy 18.18 13.85 29 242030 15557 50347508
Rheumatic disorder 18.07 13.85 29 242030 1514 50361551
Eyelid exfoliation 17.98 13.85 10 242049 126 50362939
Pre-eclampsia 17.91 13.85 8 242051 8036 50355029
Nephropathy toxic 17.86 13.85 8 242051 8021 50355044
Electrocardiogram abnormal 17.84 13.85 7 242052 7598 50355467
Bronchopulmonary aspergillosis 17.79 13.85 7 242052 7585 50355480
Unevaluable event 17.78 13.85 138 241921 45928 50317137
Adenoiditis 17.74 13.85 7 242052 37 50363028
Oral lichen planus 17.67 13.85 17 242042 521 50362544
Atrioventricular block first degree 17.65 13.85 4 242055 6197 50356868
Hepatic cirrhosis 17.57 13.85 144 241915 17433 50345632
Elbow deformity 17.55 13.85 27 242032 1359 50361706
Generalised oedema 17.52 13.85 24 242035 13707 50349358
Injection site mass 17.52 13.85 30 242029 15650 50347415
Clear cell renal cell carcinoma 17.48 13.85 25 242034 1178 50361887
Taste disorder 17.44 13.85 9 242050 8315 50354750
C-reactive protein 17.43 13.85 21 242038 835 50362230
Neck pain 17.40 13.85 376 241683 56691 50306374
Osteopenia 17.32 13.85 140 241919 16878 50346187
Rash papular 17.15 13.85 21 242038 12583 50350482
Blood lactate dehydrogenase increased 17.14 13.85 43 242016 19519 50343546
Colitis microscopic 16.98 13.85 69 241990 6451 50356614
Device failure 16.91 13.85 3 242056 5525 50357540
Hyperaesthesia 16.88 13.85 9 242050 8164 50354901
C-reactive protein decreased 16.84 13.85 20 242039 783 50362282
Enterococcal infection 16.77 13.85 6 242053 6892 50356173
Aortic valve incompetence 16.69 13.85 3 242056 5473 50357592
Tooth fracture 16.69 13.85 13 242046 9638 50353427
Smear cervix abnormal 16.63 13.85 39 242020 2702 50360363
Gingivitis 16.61 13.85 7 242052 7277 50355788
Rales 16.56 13.85 14 242045 9964 50353101
Aphonia 16.55 13.85 10 242049 8468 50354597
Hereditary angioedema 16.55 13.85 3 242056 5439 50357626
Cerebral ischaemia 16.44 13.85 4 242055 5904 50357161
HLA marker study positive 16.38 13.85 11 242048 198 50362867
Multiple allergies 16.37 13.85 82 241977 8381 50354684
Tender joint count increased 16.36 13.85 7 242052 47 50363018
Aortic arteriosclerosis 16.30 13.85 3 242056 5379 50357686
Ureterocele 16.29 13.85 5 242054 10 50363055
Retinal toxicity 16.26 13.85 24 242035 1164 50361901
Dermatitis bullous 16.19 13.85 7 242052 7166 50355899
Parotid gland enlargement 16.16 13.85 19 242040 736 50362329
Increased appetite 16.13 13.85 10 242049 8351 50354714
Prescribed underdose 16.12 13.85 131 241928 15818 50347247
Fungal infection 16.11 13.85 81 241978 29884 50333181
Hypersensitivity vasculitis 16.10 13.85 49 242010 3966 50359099
Hepatic function abnormal 16.10 13.85 91 241968 32590 50330475
Antinuclear antibody positive 16.04 13.85 66 241993 6206 50356859
Vitreous floaters 16.01 13.85 3 242056 5311 50357754
Muscle fatigue 15.99 13.85 34 242025 2205 50360860
Pelvic pain 15.99 13.85 18 242041 11195 50351870
Myositis 15.95 13.85 9 242050 7911 50355154
Wound infection fungal 15.87 13.85 9 242050 118 50362947
Axial spondyloarthritis 15.87 13.85 11 242048 209 50362856
Eye pain 15.82 13.85 76 241983 28373 50334692
Micturition urgency 15.79 13.85 10 242049 8254 50354811
Immune thrombocytopenia 15.78 13.85 12 242047 9005 50354060
Dysstasia 15.75 13.85 39 242020 17780 50345285
Pharyngitis 15.71 13.85 38 242021 17465 50345600
Eyelid ptosis 15.71 13.85 5 242054 6182 50356883
Vaginal discharge 15.70 13.85 3 242056 5237 50357828
Shoulder arthroplasty 15.67 13.85 44 242015 3404 50359661
Granulocytopenia 15.66 13.85 3 242056 5228 50357837
Infusion site extravasation 15.44 13.85 7 242052 6969 50356096
Tubulointerstitial nephritis 15.31 13.85 31 242028 15180 50347885
Squamous cell carcinoma 15.29 13.85 9 242050 7730 50355335
Hyperreflexia 15.18 13.85 3 242056 5115 50357950
Pulmonary tuberculosis 15.17 13.85 50 242009 4223 50358842
Aplastic anaemia 15.16 13.85 9 242050 7694 50355371
Jaundice cholestatic 15.16 13.85 3 242056 5108 50357957
Glycosylated haemoglobin increased 15.15 13.85 17 242042 10589 50352476
Blood pressure systolic abnormal 15.14 13.85 75 241984 7631 50355434
Eosinophil count increased 15.14 13.85 12 242047 8818 50354247
Nystagmus 15.02 13.85 4 242055 5557 50357508
Maternal drugs affecting foetus 15.01 13.85 3 242056 5074 50357991
Ganglioneuroma 14.94 13.85 9 242050 133 50362932
Injection site induration 14.92 13.85 11 242048 8386 50354679
Diverticulitis 14.80 13.85 232 241827 32950 50330115
Crepitations 14.78 13.85 64 241995 6155 50356910
Cushingoid 14.75 13.85 67 241992 6578 50356487
Seasonal allergy 14.70 13.85 30 242029 14646 50348419
Mood altered 14.67 13.85 24 242035 12749 50350316
Pneumothorax 14.65 13.85 28 242031 14006 50349059
Herpes simplex 14.62 13.85 8 242051 7154 50355911
Upper limb fracture 14.61 13.85 34 242025 15839 50347226
Intestinal ischaemia 14.61 13.85 7 242052 6750 50356315
Breast pain 14.59 13.85 9 242050 7535 50355530
Pruritus 14.57 13.85 1163 240896 282405 50080660
Rotator cuff repair 14.57 13.85 28 242031 1688 50361377
Urine output decreased 14.56 13.85 17 242042 10404 50352661
Osteosclerosis 14.56 13.85 43 242016 3424 50359641
Rash pruritic 14.51 13.85 315 241744 47531 50315534
Cyst 14.50 13.85 104 241955 12083 50350982
Low birth weight baby 14.50 13.85 5 242054 5876 50357189
Extrapulmonary tuberculosis 14.44 13.85 12 242047 302 50362763
Musculoskeletal chest pain 14.43 13.85 43 242016 18443 50344622
Cholecystitis acute 14.42 13.85 8 242051 7098 50355967
Liver disorder 14.30 13.85 254 241805 36968 50326097
Thirst 14.22 13.85 18 242041 10632 50352433
Bursitis infective 14.19 13.85 23 242036 1211 50361854
Inflammatory marker increased 14.18 13.85 59 242000 5575 50357490
Staphylococcal bacteraemia 14.18 13.85 3 242056 4874 50358191
Exercise tolerance decreased 14.16 13.85 3 242056 4871 50358194
Erysipelas 14.06 13.85 7 242052 6601 50356464
Viral upper respiratory tract infection 14.02 13.85 8 242051 6988 50356077
Procedural complication 13.95 13.85 3 242056 4820 50358245
Oral mucosal blistering 13.91 13.85 3 242056 4809 50358256

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 1878.34 14.15 2536 43517 360634 29167840
Drug intolerance 1269.78 14.15 841 45212 47538 29480936
Joint swelling 1085.01 14.15 771 45282 48859 29479615
Synovitis 752.06 14.15 358 45695 10532 29517942
Contraindicated product administered 700.65 14.15 405 45648 17861 29510613
Apparent death 595.56 14.15 219 45834 3285 29525189
Treatment failure 526.65 14.15 446 45607 36493 29491981
C-reactive protein abnormal 460.66 14.15 218 45835 6318 29522156
Arthropathy 456.50 14.15 329 45724 21225 29507249
Pain 449.26 14.15 887 45166 170545 29357929
Diverticulitis 434.97 14.15 296 45757 17408 29511066
Musculoskeletal stiffness 425.89 14.15 398 45655 37060 29491414
Therapeutic product effect decreased 387.94 14.15 340 45713 29111 29499363
Psoriatic arthropathy 383.31 14.15 255 45798 14436 29514038
Arthralgia 375.73 14.15 731 45322 138886 29389588
Rheumatoid arthritis 371.93 14.15 345 45708 31807 29496667
C-reactive protein increased 320.00 14.15 369 45684 43894 29484580
Loss of personal independence in daily activities 307.81 14.15 280 45773 25160 29503314
Drug hypersensitivity 300.44 14.15 446 45607 67960 29460514
Hand deformity 292.69 14.15 114 45939 2016 29526458
Red blood cell sedimentation rate increased 292.68 14.15 168 45885 7293 29521181
Mobility decreased 235.13 14.15 243 45810 25537 29502937
Death 194.20 14.15 150 45903 341934 29186540
Arthritis 193.26 14.15 216 45837 24803 29503671
Lymphoma 185.37 14.15 140 45913 9688 29518786
Pulmonary thrombosis 183.44 14.15 119 45934 6446 29522028
Enthesopathy 181.68 14.15 97 45956 3646 29524828
Therapeutic product effect incomplete 167.65 14.15 253 45800 39052 29489422
Toxicity to various agents 166.53 14.15 34 46019 173627 29354847
Knee arthroplasty 161.57 14.15 105 45948 5704 29522770
Impaired work ability 157.00 14.15 102 45951 5538 29522936
Onychoclasis 156.64 14.15 69 45984 1684 29526790
Acute kidney injury 155.89 14.15 112 45941 265155 29263319
Tenosynovitis 146.22 14.15 84 45969 3649 29524825
Ankylosing spondylitis 142.63 14.15 86 45967 4090 29524384
Terminal state 137.87 14.15 79 45974 3415 29525059
Inflammation 135.53 14.15 172 45881 22556 29505918
Hypotension 135.22 14.15 67 45986 194287 29334187
Drug tolerance decreased 133.40 14.15 57 45996 1289 29527185
Drug interaction 125.75 14.15 76 45977 197309 29331165
Deep vein thrombosis 124.95 14.15 276 45777 57123 29471351
Gastrointestinal disorder 118.44 14.15 182 45871 28524 29499950
Polyarthritis 113.88 14.15 73 45980 3872 29524602
Red blood cell sedimentation rate abnormal 112.66 14.15 60 45993 2243 29526231
Pulmonary fibrosis 112.60 14.15 130 45923 15452 29513022
Febrile neutropenia 111.68 14.15 20 46033 112220 29416254
Tooth loss 111.07 14.15 70 45983 3604 29524870
Psoriasis 110.69 14.15 188 45865 32039 29496435
Joint range of motion decreased 109.21 14.15 84 45969 5970 29522504
Completed suicide 106.98 14.15 9 46044 90237 29438237
Gastric disorder 99.52 14.15 102 45951 10602 29517872
Confusional state 98.47 14.15 38 46015 127839 29400635
Musculoskeletal pain 98.24 14.15 168 45885 28785 29499689
Rheumatoid factor positive 96.74 14.15 37 46016 621 29527853
Anaemia 95.94 14.15 103 45950 200848 29327626
Joint stiffness 94.91 14.15 94 45959 9379 29519095
Tongue disorder 94.02 14.15 69 45984 4567 29523907
Herpes zoster 93.69 14.15 168 45885 29884 29498590
Dehydration 91.88 14.15 32 46021 114716 29413758
Sleep disorder due to general medical condition, insomnia type 88.09 14.15 42 46011 1236 29527238
Alopecia 87.28 14.15 127 45926 18957 29509517
Pulmonary embolism 86.49 14.15 289 45764 76245 29452229
Malignant neoplasm progression 85.81 14.15 8 46045 73851 29454623
Photosensitivity reaction 85.67 14.15 88 45965 9170 29519304
Bone erosion 84.47 14.15 53 46000 2707 29525767
Arthritis bacterial 83.50 14.15 63 45990 4350 29524124
Joint arthroplasty 81.76 14.15 33 46020 643 29527831
Tendonitis 81.61 14.15 80 45973 7881 29520593
Alanine aminotransferase abnormal 81.12 14.15 53 46000 2904 29525570
Interstitial lung disease 77.15 14.15 231 45822 57487 29470987
Disability 76.88 14.15 60 45993 4356 29524118
Hip arthroplasty 76.36 14.15 56 45997 3702 29524772
Swelling 75.98 14.15 169 45884 35114 29493360
Seronegative arthritis 74.98 14.15 34 46019 890 29527584
Bladder transitional cell carcinoma 74.67 14.15 47 46006 2414 29526060
Liver function test increased 74.10 14.15 92 45961 11793 29516681
Condition aggravated 73.36 14.15 433 45620 145862 29382612
Hyperkalaemia 73.08 14.15 6 46047 61386 29467088
Cytology abnormal 71.65 14.15 26 46027 374 29528100
Colitis ulcerative 70.41 14.15 93 45960 12676 29515798
Bradycardia 69.05 14.15 10 46043 65619 29462855
Osteoarthritis 68.03 14.15 110 45943 17993 29510481
Uveitis 65.18 14.15 62 45991 5885 29522589
Blood creatinine increased 64.30 14.15 26 46027 85076 29443398
Atrial fibrillation 63.98 14.15 43 46010 105603 29422871
Nodule 63.20 14.15 57 45996 5055 29523419
Neoplasm malignant 62.45 14.15 102 45951 16823 29511651
Intestinal sepsis 61.93 14.15 24 46029 418 29528056
Rhabdomyolysis 60.09 14.15 11 46042 60797 29467677
Immobile 58.58 14.15 39 46014 2206 29526268
Foot deformity 58.16 14.15 49 46004 3966 29524508
Thrombocytopenia 56.92 14.15 76 45977 134747 29393727
Decreased appetite 56.36 14.15 87 45966 145255 29383219
Cardiac arrest 55.74 14.15 32 46021 85559 29442915
Hypokalaemia 54.34 14.15 7 46046 50196 29478278
Intentional product use issue 53.87 14.15 167 45886 42331 29486143
Seizure 53.61 14.15 40 46013 93083 29435391
Axial spondyloarthritis 53.49 14.15 19 46034 256 29528218
Overdose 53.19 14.15 29 46024 79790 29448684
Somnolence 52.01 14.15 42 46011 93913 29434561
Impaired quality of life 50.90 14.15 38 46015 2581 29525893
Dyspnoea 49.21 14.15 303 45750 326429 29202045
Infection 49.12 14.15 243 45810 76508 29451966
Prerenal failure 48.93 14.15 32 46021 1756 29526718
Limb discomfort 48.66 14.15 67 45986 9501 29518973
Tuberculosis 48.58 14.15 58 45995 7138 29521336
International normalised ratio increased 48.48 14.15 6 46047 44366 29484108
Cardio-respiratory arrest 48.20 14.15 10 46043 50591 29477883
Pain in extremity 47.85 14.15 315 45738 110118 29418356
X-ray abnormal 46.57 14.15 20 46033 458 29528016
Soft tissue swelling 46.11 14.15 18 46035 320 29528154
Constipation 45.52 14.15 67 45986 114093 29414381
Dizziness 45.34 14.15 148 45905 189536 29338938
Musculoskeletal discomfort 44.28 14.15 52 46001 6289 29522185
Lymphadenopathy 44.15 14.15 111 45942 24938 29503536
Arthrodesis 44.08 14.15 19 46034 439 29528035
Rheumatoid nodule 43.97 14.15 32 46021 2090 29526384
Hypoxia 43.84 14.15 10 46043 47369 29481105
Agitation 43.33 14.15 13 46040 51291 29477183
Hepatic enzyme abnormal 42.40 14.15 32 46021 2210 29526264
Hallucination 42.25 14.15 9 46044 44703 29483771
Hospitalisation 41.97 14.15 10 46043 45978 29482496
Electrocardiogram QT prolonged 41.73 14.15 4 46049 36133 29492341
Pulmonary tuberculosis 41.71 14.15 42 46011 4273 29524201
Asthenia 41.69 14.15 183 45870 215067 29313407
Rheumatoid factor negative 41.66 14.15 22 46031 808 29527666
Disease progression 41.25 14.15 40 46013 81876 29446598
Off label use 40.88 14.15 676 45377 300124 29228350
Pulmonary toxicity 40.81 14.15 44 46009 4846 29523628
Hyponatraemia 40.29 14.15 28 46025 67605 29460869
Drug reaction with eosinophilia and systemic symptoms 40.21 14.15 115 45938 27877 29500597
Renal impairment 39.49 14.15 41 46012 81292 29447182
Cerebrovascular accident 39.38 14.15 37 46016 76874 29451600
Anti-cyclic citrullinated peptide antibody positive 38.99 14.15 21 46032 803 29527671
Thrombosis 37.93 14.15 150 45903 42895 29485579
Syncope 37.32 14.15 43 46010 81328 29447146
Grip strength decreased 37.27 14.15 30 46023 2277 29526197
Frequent bowel movements 37.27 14.15 58 45995 9181 29519293
Blood creatine phosphokinase increased 36.77 14.15 9 46044 40635 29487839
Peripheral swelling 36.72 14.15 196 45857 63543 29464931
Dactylitis 36.55 14.15 19 46034 675 29527799
Platelet count decreased 36.53 14.15 67 45986 104605 29423869
Diarrhoea 36.51 14.15 337 45716 332361 29196113
Suicide attempt 36.33 14.15 5 46048 34105 29494369
Hypoglycaemia 36.13 14.15 15 46038 48331 29480143
Blood pressure fluctuation 35.94 14.15 89 45964 19805 29508669
Respiratory distress 35.92 14.15 4 46049 32102 29496372
Limb deformity 35.88 14.15 17 46036 493 29527981
Lactic acidosis 35.86 14.15 3 46050 30244 29498230
Fine motor skill dysfunction 35.85 14.15 25 46028 1526 29526948
Multiple organ dysfunction syndrome 33.94 14.15 29 46024 63087 29465387
Ill-defined disorder 33.49 14.15 63 45990 11615 29516859
Mental status changes 33.06 14.15 7 46046 34920 29493554
Metabolic acidosis 32.81 14.15 9 46044 37653 29490821
Blood glucose increased 31.84 14.15 27 46026 58957 29469517
Muscular weakness 31.59 14.15 30 46023 62022 29466452
Vomiting 31.26 14.15 198 45855 212062 29316412
Septic shock 30.97 14.15 31 46022 62529 29465945
Iritis 30.78 14.15 21 46032 1237 29527237
Lymphoedema 30.74 14.15 32 46021 3385 29525089
Abdominal pain 30.68 14.15 108 45945 135249 29393225
Fall 30.54 14.15 157 45896 177021 29351453
Xyphoid retraction 30.08 14.15 11 46042 162 29528312
Renal failure 29.89 14.15 299 45754 118300 29410174
Coma 29.86 14.15 12 46041 39438 29489036
Delirium 29.80 14.15 12 46041 39385 29489089
Feeding disorder 29.70 14.15 41 46012 5826 29522648
Urticaria 28.74 14.15 164 45889 54496 29473978
White blood cell count decreased 28.51 14.15 54 45999 83308 29445166
Oedema peripheral 28.16 14.15 76 45977 103481 29424993
Erythema 27.07 14.15 206 45847 75400 29453074
Plasma cell myeloma 26.95 14.15 12 46041 37103 29491371
Aggression 26.59 14.15 11 46042 35530 29492944
Tuberculin test positive 26.46 14.15 18 46035 1055 29527419
Feeling abnormal 26.46 14.15 160 45893 54285 29474189
Sensitivity to weather change 26.27 14.15 20 46033 1399 29527075
Rash vesicular 26.10 14.15 25 46028 2393 29526081
Neutropenia 26.05 14.15 111 45942 131600 29396874
Abdominal distension 26.04 14.15 20 46033 45891 29482583
Abscess 25.95 14.15 51 46002 9711 29518763
Gastrointestinal haemorrhage 25.92 14.15 53 46000 79480 29448994
Respiratory failure 25.88 14.15 72 45981 97059 29431415
Aortic bruit 25.81 14.15 10 46043 174 29528300
Sacroiliitis 25.66 14.15 18 46035 1109 29527365
Neck mass 25.51 14.15 20 46033 1461 29527013
Medium-chain acyl-coenzyme A dehydrogenase deficiency 25.46 14.15 7 46046 37 29528437
Wrist deformity 25.45 14.15 12 46041 344 29528130
Angioedema 25.34 14.15 9 46044 31906 29496568
Fragile X syndrome 25.30 14.15 7 46046 38 29528436
Cutaneous symptom 25.17 14.15 11 46042 263 29528211
Wrong technique in product usage process 24.72 14.15 9 46044 31419 29497055
Cerebral haemorrhage 24.71 14.15 9 46044 31417 29497057
Neck pain 24.19 14.15 81 45972 21366 29507108
Epistaxis 24.04 14.15 27 46026 51677 29476797
Nasopharyngitis 23.89 14.15 167 45886 59498 29468976
Haemorrhage 23.87 14.15 21 46032 45051 29483423
Ankle deformity 23.82 14.15 10 46043 216 29528258
Depressed level of consciousness 23.76 14.15 14 46039 36928 29491546
Loss of consciousness 23.58 14.15 50 46003 74006 29454468
Joint ankylosis 23.54 14.15 12 46041 409 29528065
Haematemesis 23.17 14.15 5 46048 24621 29503853
Red blood cell sedimentation rate 23.13 14.15 13 46040 541 29527933
Pneumonia 22.89 14.15 356 45697 319816 29208658
Bone tuberculosis 22.87 14.15 11 46042 330 29528144
Contraindication to medical treatment 22.79 14.15 12 46041 438 29528036
Exostosis 22.72 14.15 28 46025 3561 29524913
Splenic embolism 22.70 14.15 9 46044 167 29528307
Stomatitis 22.65 14.15 116 45937 36997 29491477
Trisomy 8 22.65 14.15 7 46046 59 29528415
Pyrexia 22.57 14.15 314 45739 287308 29241166
Fibromyalgia 22.54 14.15 24 46029 2605 29525869
Joint effusion 22.33 14.15 30 46023 4154 29524320
Dysphagia 22.10 14.15 32 46021 54894 29473580
Microcephaly 21.94 14.15 14 46039 736 29527738
Oesophageal infection 21.83 14.15 10 46043 268 29528206
Chronic kidney disease 21.78 14.15 15 46038 36401 29492073
Ossicle disorder 21.77 14.15 6 46047 32 29528442
Cardiac failure 21.69 14.15 58 45995 79229 29449245
Cognitive disorder 21.65 14.15 5 46048 23494 29504980
Hepatic failure 21.64 14.15 11 46042 31501 29496973
Blood bilirubin increased 21.58 14.15 13 46040 33880 29494594
Elbow operation 21.56 14.15 8 46045 123 29528351
Therapy partial responder 21.47 14.15 33 46020 5166 29523308
Swollen joint count increased 21.38 14.15 8 46045 126 29528348
Cryopyrin associated periodic syndrome 21.33 14.15 7 46046 73 29528401
Granuloma skin 21.24 14.15 13 46040 635 29527839
Maternal exposure during pregnancy 21.15 14.15 29 46024 4094 29524380
Neutrophil count decreased 21.09 14.15 22 46031 43545 29484929
Diffuse idiopathic skeletal hyperostosis 21.04 14.15 6 46047 37 29528437
Joint space narrowing 20.99 14.15 7 46046 77 29528397
Pneumonia aspiration 20.84 14.15 16 46037 36721 29491753
Sideroblastic anaemia 20.84 14.15 9 46044 209 29528265
Enzyme abnormality 20.50 14.15 8 46045 142 29528332
Stent placement 20.18 14.15 29 46024 4277 29524197
Tender joint count increased 20.03 14.15 6 46047 45 29528429
Headache 19.95 14.15 381 45672 173626 29354848
Intentional product misuse 19.78 14.15 15 46038 34646 29493828
Urinary tract infection 19.74 14.15 53 46000 72301 29456173
Nephrolithiasis 19.72 14.15 85 45968 25249 29503225
Intestinal diaphragm disease 19.69 14.15 9 46044 240 29528234
Oral pustule 19.62 14.15 9 46044 242 29528232
Transient ischaemic attack 19.46 14.15 6 46047 23264 29505210
Vitamin B1 decreased 19.45 14.15 9 46044 247 29528227
Therapeutic response decreased 19.30 14.15 83 45970 24628 29503846
Blood urea increased 19.02 14.15 10 46043 28102 29500372
Hepatic enzyme increased 18.82 14.15 103 45950 33696 29494778
Acute lung injury 18.75 14.15 16 46037 1317 29527157
C-reactive protein 18.49 14.15 7 46046 114 29528360
Lacrimal duct neoplasm 18.41 14.15 5 46048 25 29528449
Mantle cell lymphoma stage III 18.41 14.15 5 46048 25 29528449
Blood parathyroid hormone decreased 18.39 14.15 13 46040 811 29527663
Sitting disability 18.22 14.15 7 46046 119 29528355
Memory impairment 18.13 14.15 18 46035 36452 29492022
Diaphragmatic injury 18.01 14.15 7 46046 123 29528351
Restlessness 18 14.15 6 46047 22139 29506335
Panniculitis 17.89 14.15 15 46038 1206 29527268
Disorientation 17.86 14.15 12 46041 29503 29498971
Cardiogenic shock 17.85 14.15 4 46049 19186 29509288
Hyperhidrosis 17.81 14.15 47 46006 64493 29463981
Blood pressure decreased 17.80 14.15 27 46026 45450 29483024
Spondylitis 17.62 14.15 14 46039 1043 29527431
Muscle spasms 17.50 14.15 48 46005 65034 29463440
Inflammatory pain 17.45 14.15 7 46046 134 29528340
Anxiety 17.44 14.15 71 45982 85294 29443180
Drug level increased 17.30 14.15 4 46049 18783 29509691
Prostate cancer 17.15 14.15 82 45971 25445 29503029
Bronchiectasis 17.02 14.15 34 46019 6551 29521923
Encephalopathy 17.00 14.15 14 46039 31029 29497445
Acute myocardial infarction 16.88 14.15 31 46022 48407 29480067
Mixed connective tissue disease 16.87 14.15 5 46048 36 29528438
Muscle strain 16.86 14.15 24 46029 3509 29524965
Epilepsy 16.83 14.15 4 46049 18428 29510046
Myalgia 16.79 14.15 59 45994 73960 29454514
Hypersensitivity 16.66 14.15 140 45913 52763 29475711
Lupus-like syndrome 16.55 14.15 19 46034 2243 29526231
Haemoptysis 16.46 14.15 14 46039 30536 29497938
Skin laceration 16.42 14.15 46 46007 11016 29517458
Thrombocytosis 16.33 14.15 23 46030 3330 29525144
Localised infection 16.31 14.15 53 46000 13763 29514711
Osteonecrosis of jaw 16.27 14.15 3 46050 16507 29511967
Pulmonary mass 16.25 14.15 45 46008 10703 29517771
Urinary incontinence 16.23 14.15 3 46050 16478 29511996
Raoultella ornithinolytica infection 16.10 14.15 4 46049 13 29528461
Pancreatitis acute 16.02 14.15 9 46044 24376 29504098
Generalised tonic-clonic seizure 15.88 14.15 5 46048 19134 29509340
Hyperglycaemia 15.83 14.15 18 46035 34269 29494205
Hepatic cirrhosis 15.80 14.15 54 45999 14390 29514084
Rheumatoid lung 15.70 14.15 9 46044 389 29528085
Seborrhoeic dermatitis 15.64 14.15 15 46038 1438 29527036
Squamous cell carcinoma 15.58 14.15 43 46010 10208 29518266
Physical disability 15.53 14.15 14 46039 1240 29527234
Spinal cord oedema 15.44 14.15 7 46046 183 29528291
Epstein Barr virus positive mucocutaneous ulcer 15.40 14.15 8 46045 284 29528190
Cholestasis 14.93 14.15 9 46044 23453 29505021
Inflammatory marker increased 14.76 14.15 23 46030 3644 29524830
Haematuria 14.73 14.15 29 46024 44110 29484364
Arthritis infective 14.69 14.15 20 46033 2804 29525670
Joint contracture 14.68 14.15 16 46037 1784 29526690
Axillary pain 14.59 14.15 8 46045 317 29528157
Liver disorder 14.41 14.15 83 45970 27666 29500808
Acne 14.34 14.15 39 46014 9181 29519293
Mycobacterial infection 14.27 14.15 16 46037 1840 29526634
Bursa removal 14.23 14.15 6 46047 131 29528343
Full blood count abnormal 14.22 14.15 3 46050 15010 29513464

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 4806.23 13.32 9295 204099 830952 63454386
Drug intolerance 4566.77 13.32 4248 209146 183744 64101594
Joint swelling 2991.30 13.32 3617 209777 211765 64073573
Contraindicated product administered 2932.79 13.32 2600 210794 105229 64180109
Synovitis 2657.80 13.32 2371 211023 96719 64188619
Treatment failure 2637.89 13.32 2539 210855 114277 64171061
Therapeutic product effect decreased 1838.79 13.32 2082 211312 113269 64172069
Arthropathy 1829.94 13.32 2125 211269 118842 64166496
Hand deformity 1480.64 13.32 1399 211995 61372 64223966
Systemic lupus erythematosus 1473.90 13.32 1537 211857 76075 64209263
Pemphigus 1420.50 13.32 1347 212047 59354 64225984
Drug hypersensitivity 1284.28 13.32 2585 210809 235230 64050108
Rheumatoid arthritis 1248.30 13.32 2071 211323 162223 64123115
Abdominal discomfort 1241.61 13.32 2189 211205 180133 64105205
C-reactive protein abnormal 1219.88 13.32 904 212490 28143 64257195
Glossodynia 1191.96 13.32 1261 212133 63435 64221903
Pain 1179.22 13.32 4257 209137 549254 63736084
Anti-cyclic citrullinated peptide antibody positive 1163.53 13.32 1102 212292 48460 64236878
Musculoskeletal stiffness 1159.34 13.32 1714 211680 121492 64163846
Arthralgia 1138.86 13.32 3626 209768 438634 63846704
Rheumatoid factor positive 1097.17 13.32 916 212478 34022 64251316
Swelling 1049.75 13.32 1892 211502 158326 64127012
Alopecia 1044.32 13.32 1924 211470 163766 64121572
Therapeutic product effect incomplete 1012.95 13.32 1467 211927 102015 64183323
Pericarditis 952.00 13.32 1103 212291 61413 64223925
Hepatic enzyme increased 923.95 13.32 1591 211803 128352 64156986
Death 908.41 13.32 239 213155 482466 63802872
Loss of personal independence in daily activities 899.66 13.32 1153 212241 71301 64214037
Wound 830.91 13.32 1140 212254 75337 64210001
Red blood cell sedimentation rate increased 783.86 13.32 721 212673 30514 64254824
Acute kidney injury 764.43 13.32 267 213127 448973 63836365
Hypersensitivity 752.22 13.32 1863 211531 194589 64090749
Psoriatic arthropathy 751.76 13.32 818 212576 42463 64242875
Red blood cell sedimentation rate abnormal 694.59 13.32 512 212882 15794 64269544
Discomfort 693.24 13.32 1078 212316 79800 64205538
Sleep disorder due to general medical condition, insomnia type 679.86 13.32 617 212777 25653 64259685
C-reactive protein increased 676.78 13.32 1164 212230 93745 64191593
Completed suicide 670.19 13.32 15 213379 224399 64060939
Condition aggravated 656.92 13.32 2702 210692 369724 63915614
Infusion related reaction 645.56 13.32 1575 211819 162892 64122446
Duodenal ulcer perforation 633.95 13.32 673 212721 33952 64251386
Toxicity to various agents 612.95 13.32 219 213175 363294 63922044
Helicobacter infection 602.54 13.32 688 212706 37674 64247664
Hypotension 579.84 13.32 268 213126 380706 63904632
Anaemia 563.10 13.32 275 213119 378405 63906933
Drug interaction 561.49 13.32 248 213146 361835 63923503
Peripheral swelling 505.31 13.32 1681 211713 207472 64077866
Bone erosion 480.18 13.32 358 213036 11237 64274101
Mobility decreased 465.31 13.32 936 212458 84904 64200434
Product use issue 454.01 13.32 1314 212080 150401 64134937
Rash 441.22 13.32 2807 210587 455742 63829596
Febrile neutropenia 428.49 13.32 57 213337 187600 64097738
Maternal exposure during pregnancy 420.10 13.32 959 212435 94925 64190413
Infection 414.85 13.32 1450 211944 183430 64101908
Dehydration 413.23 13.32 104 213290 216659 64068679
Knee arthroplasty 411.76 13.32 477 212917 26522 64258816
Drug abuse 402.44 13.32 7 213387 132367 64152971
Rheumatoid nodule 395.52 13.32 331 213063 12320 64273018
Thrombocytopenia 378.25 13.32 134 213260 223667 64061671
Irritable bowel syndrome 374.24 13.32 536 212858 36833 64248505
Osteoarthritis 371.46 13.32 714 212680 62622 64222716
Gastrointestinal disorder 365.35 13.32 872 212522 88837 64196501
Muscle injury 365.07 13.32 444 212950 25993 64259345
Disability 361.09 13.32 309 213085 11863 64273475
Cardiac arrest 356.00 13.32 45 213349 154019 64131319
Inflammation 353.75 13.32 712 212682 64588 64220750
Constipation 352.12 13.32 159 213235 229178 64056160
Arthritis 345.96 13.32 819 212575 82995 64202343
Folliculitis 333.39 13.32 453 212941 29624 64255714
Hip arthroplasty 331.93 13.32 381 213013 20970 64264368
Seizure 318.14 13.32 80 213314 166812 64118526
Malignant neoplasm progression 313.77 13.32 14 213380 112857 64172481
Blood parathyroid hormone decreased 306.27 13.32 228 213166 7138 64278200
Atrial fibrillation 300.23 13.32 96 213298 170993 64114345
Drug tolerance decreased 298.58 13.32 220 213174 6778 64278560
Granuloma skin 295.95 13.32 207 213187 5867 64279471
Dyspnoea 290.11 13.32 1309 212085 717365 63567973
Hyperkalaemia 289.73 13.32 10 213384 101119 64184219
Ankylosing spondylitis 288 13.32 230 213164 8004 64277334
Somnolence 287.24 13.32 158 213236 203487 64081851
Panniculitis 278.98 13.32 233 213161 8646 64276692
Hyponatraemia 277.18 13.32 74 213320 148265 64137073
Bradycardia 276.84 13.32 33 213361 118186 64167152
Cardio-respiratory arrest 270.90 13.32 13 213381 98380 64186958
Enthesopathy 270.37 13.32 237 213157 9401 64275937
Impaired healing 269.36 13.32 609 212785 59864 64225474
Fall 268.81 13.32 615 212779 416211 63869127
Grip strength decreased 267.87 13.32 257 213137 11467 64273871
Asthenia 267.69 13.32 642 212752 427402 63857936
Neutropenia 265.54 13.32 241 213153 239383 64045955
Platelet count decreased 245.50 13.32 124 213270 167587 64117751
Respiratory failure 243.80 13.32 114 213280 161069 64124269
Tenosynovitis 236.24 13.32 241 213153 11592 64273746
Overdose 235.03 13.32 117 213277 159449 64125889
Polyarthritis 231.55 13.32 218 213176 9497 64275841
Cardiac failure congestive 231.32 13.32 72 213322 130508 64154830
Rhabdomyolysis 229.27 13.32 20 213374 91706 64193632
Blister 226.42 13.32 685 212709 80282 64205056
Gastrointestinal haemorrhage 225.51 13.32 78 213316 132234 64153104
Anxiety 219.52 13.32 208 213186 202441 64082897
Oedema peripheral 218.46 13.32 224 213170 210093 64075245
Hypoglycaemia 215.71 13.32 23 213371 89869 64195469
Cerebrovascular accident 214.81 13.32 93 213301 137490 64147848
Ill-defined disorder 213.53 13.32 459 212935 43593 64241745
Electrocardiogram QT prolonged 210.91 13.32 13 213381 79435 64205903
Joint stiffness 210.06 13.32 368 213026 30036 64255302
Tremor 208.96 13.32 115 213279 148115 64137223
Cardiac failure 205.83 13.32 90 213304 132283 64153055
Tachycardia 205.19 13.32 120 213274 149459 64135879
Musculoskeletal pain 202.69 13.32 661 212733 80633 64204705
Transplant dysfunction 202.45 13.32 172 213222 6536 64278802
Depressed level of consciousness 200.19 13.32 19 213375 81417 64203921
Disease progression 198.15 13.32 111 213283 141569 64143769
Hypokalaemia 197.41 13.32 78 213316 121825 64163513
Dizziness 191.26 13.32 754 212640 429409 63855929
International normalised ratio increased 190.62 13.32 20 213374 79147 64206191
Hypoxia 186.89 13.32 33 213361 88116 64197222
Agitation 181.12 13.32 36 213358 88331 64197007
Syncope 180.00 13.32 154 213240 157481 64127857
Multiple organ dysfunction syndrome 177.67 13.32 57 213337 101356 64183982
Joint range of motion decreased 175.63 13.32 265 213129 19078 64266260
Joint destruction 175.01 13.32 123 213271 3513 64281825
Fibromyalgia 173.97 13.32 373 213021 35358 64249980
Apparent death 173.53 13.32 109 213285 2567 64282771
Lactic acidosis 172.69 13.32 7 213387 61403 64223935
Deformity 170.95 13.32 152 213242 6145 64279193
Coma 168.83 13.32 41 213353 87574 64197764
Ovarian cyst 168.52 13.32 195 213199 10823 64274515
Adverse event 168.42 13.32 391 213003 39098 64246240
Swollen joint count increased 165.25 13.32 163 213231 7526 64277812
Suicide attempt 163.32 13.32 21 213373 70986 64214352
Metabolic acidosis 163.18 13.32 21 213373 70937 64214401
Skin necrosis 162.08 13.32 218 213176 14111 64271227
Lower respiratory tract infection 160.89 13.32 680 212714 93934 64191404
Rheumatic fever 156.64 13.32 173 213221 9121 64276217
Mental status changes 153.75 13.32 13 213381 61149 64224189
Breast cancer stage III 153.30 13.32 104 213290 2801 64282537
Diarrhoea 153.03 13.32 1592 211802 721112 63564226
Impaired work ability 151.89 13.32 218 213176 15001 64270337
Foot deformity 151.12 13.32 227 213167 16277 64269061
Nasopharyngitis 150.88 13.32 1138 212256 194935 64090403
Ulcer 150.75 13.32 272 213122 22718 64262620
Liver function test increased 149.28 13.32 322 213072 30648 64254690
Epistaxis 147.42 13.32 70 213324 98061 64187277
Stomatitis 147.23 13.32 735 212659 108870 64176468
Vomiting 146.24 13.32 1146 212248 549971 63735367
Intentional product use issue 144.38 13.32 662 212732 94702 64190636
Musculoskeletal disorder 142.65 13.32 231 213163 17675 64267663
Product dose omission issue 142.44 13.32 267 213127 194480 64090858
Decreased appetite 141.44 13.32 468 212926 280821 64004517
Sinusitis 141.23 13.32 896 212498 145032 64140306
Unresponsive to stimuli 140.84 13.32 6 213388 50387 64234951
White blood cell count decreased 140.37 13.32 190 213204 157647 64127691
Hallucination 140.36 13.32 34 213360 72754 64212584
Musculoskeletal deformity 138.21 13.32 59 213335 595 64284743
Respiratory distress 137.59 13.32 9 213385 52322 64233016
Balance disorder 135.36 13.32 54 213340 83872 64201466
Seronegative arthritis 134.84 13.32 94 213300 2649 64282689
Chest pain 134.10 13.32 371 213023 235609 64049729
Human antichimeric antibody positive 132.16 13.32 73 213321 1343 64283995
Respiratory arrest 131.18 13.32 12 213382 52973 64232365
Sepsis 130.98 13.32 362 213032 229979 64055359
Cognitive disorder 129.86 13.32 15 213379 55072 64230266
Disorientation 129.64 13.32 16 213378 55812 64229526
Hyperglycaemia 128.85 13.32 23 213371 60945 64224393
Vision blurred 128.80 13.32 69 213325 90247 64195091
Renal failure 124.32 13.32 259 213135 181429 64103909
Dysphagia 123.55 13.32 103 213291 106709 64178629
Body height below normal 122.80 13.32 76 213318 1742 64283596
Encephalopathy 122.56 13.32 23 213371 58796 64226542
Urinary tract infection 122.21 13.32 377 213017 231219 64054119
Blood creatine phosphokinase increased 121.79 13.32 23 213371 58535 64226803
Diverticulitis 121.62 13.32 341 213053 38277 64247061
Hyperhidrosis 119.77 13.32 142 213252 124778 64160560
Multiple sclerosis relapse 118.03 13.32 4 213390 41131 64244207
Therapeutic response decreased 117.37 13.32 410 212984 51778 64233560
Pneumonia aspiration 115.63 13.32 27 213367 59244 64226094
Nodule 114.70 13.32 210 213184 17737 64267601
Neutrophil count decreased 114.52 13.32 56 213338 77140 64208198
Alanine aminotransferase abnormal 113.99 13.32 127 213267 6761 64278577
Acne 113.56 13.32 242 213152 22839 64262499
Sciatica 113.31 13.32 224 213170 20040 64265298
Hypervolaemia 112.47 13.32 3 213391 38282 64247056
Dysarthria 110.22 13.32 30 213364 59376 64225962
Pneumonia 109.67 13.32 1254 212140 558322 63727016
Pancytopenia 109.66 13.32 191 213203 143118 64142220
Red blood cell sedimentation rate 109.56 13.32 94 213300 3620 64281718
Sedation 109.39 13.32 7 213387 41455 64243883
Abdominal pain 109.32 13.32 597 212797 311778 63973560
Blood glucose increased 109.27 13.32 98 213296 97975 64187363
Drug eruption 108.85 13.32 314 213080 35822 64249516
Psoriasis 108.69 13.32 498 212896 71205 64214133
Haemorrhage 106.89 13.32 65 213329 79286 64206052
Hepatic failure 106.55 13.32 26 213368 55368 64229970
Intentional product misuse 106.40 13.32 53 213341 72242 64213096
Cerebral haemorrhage 106.40 13.32 20 213374 51070 64234268
Muscle spasms 106.06 13.32 190 213204 140833 64144505
Basal cell carcinoma 105.79 13.32 281 213113 30557 64254781
Serotonin syndrome 105.55 13.32 6 213388 39276 64246062
Adverse drug reaction 104.69 13.32 360 213034 45104 64240234
Dislocation of vertebra 104.45 13.32 85 213309 3039 64282299
Pulmonary oedema 103.82 13.32 66 213328 78608 64206730
Wrong technique in product usage process 102.84 13.32 43 213351 64931 64220407
Myalgia 102.80 13.32 233 213161 158384 64126954
Neoplasm progression 102.16 13.32 9 213385 40955 64244383
Chest discomfort 101.96 13.32 141 213253 115965 64169373
Blood bilirubin increased 101.40 13.32 32 213362 57521 64227817
Acute myocardial infarction 101.27 13.32 52 213342 69666 64215672
Aggression 100.88 13.32 16 213378 46216 64239122
Joint effusion 100.84 13.32 169 213225 13304 64272034
Finger deformity 100.58 13.32 104 213290 5082 64280256
Orthostatic hypotension 100.14 13.32 17 213377 46721 64238617
Tongue disorder 97.81 13.32 157 213237 11923 64273415
Acute respiratory failure 96.91 13.32 23 213371 49911 64235427
Fluid retention 96.69 13.32 38 213356 59568 64225770
Physical disability 95.60 13.32 71 213323 2214 64283124
Tenderness 94.68 13.32 204 213190 19398 64265940
Skin ulcer 94.19 13.32 340 213054 43634 64241704
Abnormal behaviour 93.96 13.32 4 213390 33618 64251720
Hypomagnesaemia 93.79 13.32 8 213386 37368 64247970
Blood cholesterol increased 93.10 13.32 370 213024 49696 64235642
Blood urea increased 92.55 13.32 17 213377 44136 64241202
Melaena 92.18 13.32 31 213363 53517 64231821
Plasma cell myeloma 91.86 13.32 20 213374 46055 64239283
Loss of consciousness 90.52 13.32 225 213169 148140 64137198
Dyspnoea exertional 90.43 13.32 67 213327 73663 64211675
Ascites 90.42 13.32 46 213348 61955 64223383
Paraesthesia 90.12 13.32 194 213200 134328 64151010
Restlessness 88.57 13.32 13 213381 39772 64245566
Blood pressure decreased 88.06 13.32 93 213301 86106 64199232
Haematuria 87.99 13.32 45 213349 60426 64224912
Contusion 87.87 13.32 662 212732 113303 64172035
Blood creatinine increased 87.54 13.32 200 213194 135582 64149756
Fine motor skill dysfunction 87.13 13.32 92 213302 4607 64280731
Pain in extremity 86.89 13.32 1447 211947 301638 63983700
Transient ischaemic attack 86.43 13.32 20 213374 44162 64241176
Tendonitis 85.56 13.32 200 213194 20082 64265256
Pulmonary hypertension 85.45 13.32 19 213375 43120 64242218
Onychomycosis 84.61 13.32 95 213299 5101 64280237
Terminal state 84.17 13.32 88 213306 4356 64280982
Presbyacusis 83.86 13.32 69 213325 2506 64282832
Exostosis 83.65 13.32 142 213252 11296 64274042
Coronary artery disease 82.09 13.32 49 213345 60384 64224954
Haemoglobin decreased 82.03 13.32 349 213045 194714 64090624
Sleep disorder 81.26 13.32 402 212992 59307 64226031
Aphasia 81.06 13.32 18 213376 40888 64244450
Pulmonary embolism 80.93 13.32 233 213161 146123 64139215
Pleural effusion 80.30 13.32 188 213206 126371 64158967
Generalised tonic-clonic seizure 80.07 13.32 17 213377 39840 64245498
Neoplasm malignant 79.71 13.32 220 213174 24468 64260870
Hypophagia 79.29 13.32 17 213377 39570 64245768
Nail disorder 78.07 13.32 118 213276 8506 64276832
Bone density abnormal 77.99 13.32 68 213326 2677 64282661
Type 2 diabetes mellitus 77.98 13.32 269 213125 33751 64251587
Fear of injection 77.89 13.32 97 213297 5815 64279523
Disturbance in attention 77.60 13.32 20 213374 41054 64244284
Neurotoxicity 77.46 13.32 3 213391 27401 64257937
Chronic kidney disease 77.23 13.32 48 213346 57871 64227467
Dactylitis 76.15 13.32 58 213336 1880 64283458
Blood potassium decreased 75.70 13.32 20 213374 40379 64244959
Fatigue 75.66 13.32 3110 210284 745620 63539718
Wrist deformity 75.46 13.32 56 213338 1744 64283594
Muscular weakness 75.43 13.32 196 213198 127142 64158196
Confusional state 75.25 13.32 530 212864 260614 64024724
Pleural thickening 74.72 13.32 66 213328 2644 64282694
Altered state of consciousness 74.46 13.32 17 213377 37885 64247453
Osteonecrosis of jaw 74.09 13.32 20 213374 39805 64245533
Hepatic enzyme abnormal 74.06 13.32 94 213300 5745 64279593
Urinary retention 74.02 13.32 35 213359 49166 64236172
Lethargy 73.40 13.32 79 213315 72515 64212823
Dyskinesia 72.86 13.32 20 213374 39368 64245970
Transplant rejection 72.76 13.32 171 213223 17230 64268108
Gastric disorder 72.35 13.32 237 213157 28960 64256378
Chronic obstructive pulmonary disease 72.19 13.32 77 213317 70971 64214367
Drug level increased 72.03 13.32 13 213381 34183 64251155
Neck deformity 71.19 13.32 53 213341 1659 64283679
Haematoma 70.98 13.32 32 213362 46218 64239120
Drug reaction with eosinophilia and systemic symptoms 70.93 13.32 361 213033 53856 64231482
Intestinal sepsis 70.86 13.32 37 213357 605 64284733
Infusion site reaction 70.25 13.32 57 213337 2029 64283309
Myoclonus 70.15 13.32 3 213391 25115 64260223
Epilepsy 70.09 13.32 13 213381 33518 64251820
Dysgeusia 69.97 13.32 34 213360 47013 64238325
Thyroid neoplasm 69.87 13.32 63 213331 2594 64282744
Cardiogenic shock 69.02 13.32 12 213382 32415 64252923
Myocardial infarction 68.89 13.32 298 213096 165523 64119815
Wheelchair user 68.63 13.32 81 213313 4591 64280747
COVID-19 67.98 13.32 69 213325 65071 64220267
Dysuria 67.90 13.32 27 213367 42030 64243308
Drug withdrawal syndrome 67.89 13.32 11 213383 31280 64254058
Bone swelling 67.65 13.32 45 213349 1172 64284166
Ejection fraction decreased 67.20 13.32 8 213386 28699 64256639
Pyrexia 67.08 13.32 1375 212019 557269 63728069
Blood iron abnormal 67.00 13.32 44 213350 1121 64284217
Psychotic disorder 66.95 13.32 16 213378 34562 64250776
Haematemesis 66.86 13.32 36 213358 46963 64238375
Adverse reaction 66.51 13.32 103 213291 7584 64277754
Abdominal distension 66.33 13.32 136 213258 95858 64189480
International normalised ratio fluctuation 65.92 13.32 64 213330 2897 64282441
Pleural fibrosis 65.86 13.32 74 213320 3976 64281362
Pulmonary thrombosis 65.86 13.32 122 213272 10396 64274942
Ischaemic stroke 65.77 13.32 9 213385 29026 64256312
Immobile 65.73 13.32 90 213304 5925 64279413
Irritability 65.50 13.32 20 213374 36726 64248612
Renal impairment 65.48 13.32 228 213166 134789 64150549
Spinal stenosis 65.02 13.32 143 213251 13788 64271550
Ventricular tachycardia 64.13 13.32 17 213377 34248 64251090
Urinary incontinence 63.86 13.32 20 213374 36131 64249207
Pancreatitis acute 63.68 13.32 31 213363 42824 64242514
Bone marrow failure 63.57 13.32 40 213354 47912 64237426
Hospitalisation 63.38 13.32 94 213300 75113 64210225
Antibody test positive 63.16 13.32 57 213337 2350 64282988
Haemorrhage intracranial 63.10 13.32 4 213390 23880 64261458
Upper gastrointestinal haemorrhage 63.09 13.32 19 213375 35201 64250137
Clostridium difficile colitis 62.71 13.32 8 213386 27215 64258123
Ovarian neoplasm 62.64 13.32 33 213361 550 64284788
Arthrodesis 62.37 13.32 53 213341 2014 64283324
Coeliac disease 62.30 13.32 98 213296 7314 64278024
Haemoptysis 62.20 13.32 43 213351 49005 64236333
Pulmonary arterial hypertension 62.11 13.32 6 213388 25361 64259977
Drug specific antibody 61.75 13.32 53 213341 2042 64283296
Hypercalcaemia 61.51 13.32 236 213158 31180 64254158
Obstructive airways disorder 60.91 13.32 4 213390 23181 64262157
Mycotic allergy 60.60 13.32 39 213355 959 64284379
Anti-cyclic citrullinated peptide antibody 60.20 13.32 44 213350 1338 64284000
Sinus tachycardia 60.19 13.32 16 213378 32172 64253166
Bloody discharge 59.80 13.32 45 213349 1432 64283906
Product quality issue 59.27 13.32 13 213381 29786 64255552
Subdural haematoma 58.37 13.32 11 213383 28043 64257295
Lymphocyte count decreased 58.15 13.32 31 213363 40668 64244670
Shock 57.84 13.32 27 213367 38213 64247125
Osteopenia 57.81 13.32 146 213248 15394 64269944
Hyperbilirubinaemia 57.71 13.32 3 213391 21202 64264136
Arrhythmia 57.66 13.32 54 213340 52890 64232448
Septic shock 57.44 13.32 169 213225 105268 64180070
Flushing 57.29 13.32 108 213286 78540 64206798
Cardiac disorder 57.25 13.32 60 213334 55756 64229582
X-ray abnormal 57.12 13.32 44 213350 1451 64283887
Blood sodium decreased 56.38 13.32 14 213380 29468 64255870
Withdrawal syndrome 56.37 13.32 6 213388 23486 64261852
Cholestasis 56.03 13.32 40 213354 44832 64240506
Axial spondyloarthritis 55.24 13.32 27 213367 381 64284957
Rheumatoid factor negative 55.00 13.32 38 213356 1055 64284283
Chills 54.41 13.32 251 213143 137013 64148325
Status epilepticus 53.37 13.32 5 213389 21658 64263680
Cerebral infarction 53.37 13.32 35 213359 41009 64244329
Product administration error 53.11 13.32 13 213381 27630 64257708
Onychomadesis 52.65 13.32 56 213338 2828 64282510
Ventricular fibrillation 52.64 13.32 8 213386 23852 64261486
Pulmonary fibrosis 52.51 13.32 217 213177 29661 64255677
Blood magnesium increased 52.48 13.32 59 213335 3172 64282166
Angioedema 52.35 13.32 77 213317 61744 64223594
Posterior reversible encephalopathy syndrome 52.24 13.32 7 213387 22939 64262399
Cytomegalovirus infection 52.18 13.32 29 213365 37170 64248168
Labelled drug-drug interaction medication error 52.01 13.32 6 213388 22056 64263282
Pallor 51.89 13.32 32 213362 38749 64246589
Extremity contracture 51.79 13.32 43 213351 1582 64283756
Jaundice 51.06 13.32 51 213343 48461 64236877
Synovial fluid analysis 51.01 13.32 42 213352 1527 64283811
Interstitial lung disease 50.97 13.32 521 212873 97211 64188127
Tenosynovitis stenosans 50.61 13.32 46 213348 1914 64283424
Therapy cessation 50.61 13.32 22 213372 32467 64252871
Dystonia 50.32 13.32 3 213391 18862 64266476
Electrolyte imbalance 50.23 13.32 11 213383 25232 64260106
Right ventricular failure 50.22 13.32 6 213388 21465 64263873
Retinitis 50.09 13.32 47 213347 2038 64283300
Tachypnoea 50.08 13.32 13 213381 26558 64258780
Hemiparesis 50.07 13.32 18 213376 29809 64255529
Uveitis 50.03 13.32 122 213272 12586 64272752
Hallucination, visual 49.88 13.32 15 213379 27819 64257519
Bone density decreased 49.71 13.32 105 213289 9847 64275491
Extrapyramidal disorder 49.56 13.32 4 213390 19548 64265790
Rectal haemorrhage 49.47 13.32 80 213314 61737 64223601
Tumour lysis syndrome 49.22 13.32 4 213390 19436 64265902
Respiratory depression 49.19 13.32 9 213385 23434 64261904
Poisoning 49.04 13.32 7 213387 21872 64263466
Neuropathy peripheral 48.92 13.32 211 213183 117314 64168024
Osteoporosis 48.76 13.32 271 213123 41809 64243529
Diabetic ketoacidosis 48.44 13.32 19 213375 29826 64255512
Pulmonary congestion 48.35 13.32 10 213384 23870 64261468
Presyncope 48.29 13.32 28 213366 35061 64250277
Hepatocellular injury 48.25 13.32 47 213347 45188 64240150
Hyperthyroidism 48.16 13.32 3 213391 18176 64267162
Dermatitis allergic 48.14 13.32 134 213260 14975 64270363
Blood alkaline phosphatase increased 47.75 13.32 70 213324 56209 64229129
Circulatory collapse 47.74 13.32 26 213368 33706 64251632
Multiple allergies 47.67 13.32 76 213318 5738 64279600
Coagulopathy 47.57 13.32 23 213371 31897 64253441
Cough 47.27 13.32 709 212685 301439 63983899
Tuberculosis 46.95 13.32 121 213273 12917 64272421
Diplopia 46.93 13.32 15 213379 26750 64258588
Full blood count decreased 46.68 13.32 9 213385 22573 64262765
Neck mass 46.46 13.32 62 213332 3982 64281356
Hepatic function abnormal 46.24 13.32 89 213305 64224 64221114
Scleritis 46.21 13.32 53 213341 2913 64282425
Myelodysplastic syndrome 45.69 13.32 17 213377 27562 64257776
Depressed mood 45.64 13.32 41 213353 40971 64244367
Torsade de pointes 45.60 13.32 3 213391 17360 64267978
Acute myeloid leukaemia 45.38 13.32 17 213377 27446 64257892
Hypothermia 45.34 13.32 6 213388 19850 64265488
Drug dependence 45.25 13.32 27 213367 33285 64252053
Emotional distress 45.16 13.32 32 213362 36006 64249332
Haemodialysis 44.70 13.32 3 213391 17074 64268264
Lyme disease 44.28 13.32 47 213347 2368 64282970
Blood pressure fluctuation 43.79 13.32 308 213086 51563 64233775
Angina pectoris 43.44 13.32 51 213343 45030 64240308
Pustular psoriasis 43.33 13.32 61 213333 4122 64281216
Ataxia 43.19 13.32 10 213384 22074 64263264
Tuberculin test positive 43.11 13.32 52 213342 3016 64282322
Breast cancer 43.08 13.32 201 213193 28947 64256391
Lower limb fracture 43.02 13.32 120 213274 13425 64271913
Foot fracture 42.86 13.32 145 213249 18012 64267326
Dry eye 42.81 13.32 200 213194 28819 64256519
Muscle twitching 42.77 13.32 6 213388 18992 64266346
Blood glucose decreased 42.28 13.32 12 213382 23111 64262227
Bacteraemia 42.27 13.32 18 213376 26893 64258445
Delirium 42.12 13.32 105 213289 69089 64216249
Dry skin 42.08 13.32 65 213329 51096 64234242
Hyperlipidaemia 41.87 13.32 12 213382 22964 64262374
Liver function test abnormal 41.85 13.32 338 213056 59063 64226275
Synovial cyst 41.65 13.32 84 213310 7623 64277715
Atrial flutter 41.62 13.32 7 213387 19373 64265965
Sudden death 41.56 13.32 8 213386 20088 64265250
Left ventricular dysfunction 41.54 13.32 4 213390 16950 64268388
Carpal tunnel syndrome 41.50 13.32 131 213263 15697 64269641
Joint injury 41.38 13.32 168 213226 22779 64262559
Device related infection 41.35 13.32 25 213369 30601 64254737
Visual acuity reduced 41.30 13.32 19 213375 27122 64258216
Vascular access complication 41.26 13.32 32 213362 1066 64284272
Shock haemorrhagic 41.04 13.32 4 213390 16787 64268551
Device issue 40.96 13.32 12 213382 22636 64262702
Acute respiratory distress syndrome 40.90 13.32 41 213353 38894 64246444
Bone cyst 40.71 13.32 43 213351 2154 64283184
Speech disorder 40.37 13.32 61 213333 48380 64236958
Ileus 40.04 13.32 13 213381 22953 64262385
Maternal exposure timing unspecified 39.88 13.32 47 213347 2660 64282678
Product prescribing error 39.56 13.32 35 213359 35234 64250104
Weight decreased 39.53 13.32 686 212708 285053 64000285
Bursitis 39.30 13.32 158 213236 21327 64264011
Red cell distribution width decreased 39.22 13.32 31 213363 1062 64284276
Therapy non-responder 39.11 13.32 361 213033 65538 64219800
Aspiration 38.80 13.32 5 213389 16880 64268458
Head injury 38.79 13.32 31 213363 32811 64252527
Memory impairment 38.69 13.32 149 213245 85533 64199805
Mitral valve incompetence 38.67 13.32 18 213376 25520 64259818
Gamma-glutamyltransferase increased 38.60 13.32 63 213331 48447 64236891
Gastrooesophageal reflux disease 38.57 13.32 143 213251 83000 64202338
Cytology abnormal 38.41 13.32 20 213374 325 64285013
Pericardial effusion 38.27 13.32 44 213350 39210 64246128
Pancreatitis 38.23 13.32 88 213306 59519 64225819
Cyanosis 37.82 13.32 13 213381 22142 64263196
Bedridden 37.63 13.32 95 213299 10014 64275324
Brain oedema 37.61 13.32 13 213381 22062 64263276
Transfusion 37.56 13.32 7 213387 17987 64267351
Deafness neurosensory 37.51 13.32 72 213322 6302 64279036
Staphylococcal infection 37.43 13.32 69 213325 50609 64234729
Nervousness 37.36 13.32 26 213368 29530 64255808
Cardiac failure acute 37.18 13.32 5 213389 16339 64268999
Mental impairment 37.17 13.32 5 213389 16338 64269000
Hypovolaemia 37.04 13.32 4 213390 15482 64269856
Device dislocation 36.90 13.32 12 213382 21166 64264172
Malnutrition 36.73 13.32 9 213385 19116 64266222
Mydriasis 36.51 13.32 4 213390 15308 64270030
Skin exfoliation 35.99 13.32 58 213336 44827 64240511
Product use in unapproved indication 35.93 13.32 392 213002 176226 64109112
Mean platelet volume decreased 35.91 13.32 36 213358 1695 64283643
Myocardial ischaemia 35.81 13.32 16 213378 23235 64262103
Thrombotic microangiopathy 35.80 13.32 6 213388 16649 64268689
Complication associated with device 35.80 13.32 4 213390 15076 64270262
Acute hepatic failure 35.70 13.32 21 213373 26091 64259247
C-reactive protein 35.61 13.32 28 213366 952 64284386
Delusion 35.54 13.32 8 213386 18006 64267332
Lupus-like syndrome 35.25 13.32 85 213309 8706 64276632
Herpes zoster 35.21 13.32 409 212985 78778 64206560
Drug tolerance 34.91 13.32 68 213326 6017 64279321
Asthma 34.90 13.32 179 213215 95046 64190292
Metastases to bone 34.87 13.32 12 213382 20423 64264915
Neutrophil count increased 34.77 13.32 20 213374 25154 64260184
Pregnancy 34.68 13.32 149 213245 20716 64264622
Joint arthroplasty 34.42 13.32 38 213356 2002 64283336
Peritonitis 34.39 13.32 20 213374 25003 64260335
Nephropathy toxic 34.11 13.32 8 213386 17506 64267832
Bone pain 34.05 13.32 66 213328 47506 64237832
Hip fracture 34.04 13.32 24 213370 27075 64258263
Diabetes mellitus inadequate control 33.91 13.32 14 213380 21307 64264031
Drug ineffective for unapproved indication 33.61 13.32 32 213362 31101 64254237
Arteriosclerosis 33.52 13.32 6 213388 15871 64269467
Lymphoma 33.50 13.32 112 213282 13829 64271509
Colitis 33.45 13.32 92 213302 58582 64226756
Colitis ulcerative 33.45 13.32 158 213236 22870 64262468
Inappropriate antidiuretic hormone secretion 33.30 13.32 16 213378 22273 64263065
Hepatic encephalopathy 33.23 13.32 14 213380 21052 64264286
Cellulitis 33.23 13.32 178 213216 93479 64191859
Ankle arthroplasty 33.17 13.32 26 213368 880 64284458
Coordination abnormal 33.05 13.32 5 213389 14959 64270379
Precancerous cells present 32.97 13.32 27 213367 974 64284364
Subarachnoid haemorrhage 32.93 13.32 10 213384 18428 64266910
Myositis 32.86 13.32 7 213387 16370 64268968
Toxic epidermal necrolysis 32.74 13.32 45 213349 37121 64248217
Tricuspid valve incompetence 32.66 13.32 8 213386 16995 64268343
Throat irritation 32.61 13.32 36 213358 32675 64252663
Throat tightness 32.56 13.32 18 213376 23142 64262196
Arteriosclerosis coronary artery 32.50 13.32 6 213388 15523 64269815
Pulmonary haemorrhage 32.36 13.32 3 213391 13106 64272232
Hypophosphataemia 32.32 13.32 5 213389 14715 64270623
Ventricular extrasystoles 32.23 13.32 9 213385 17520 64267818
Pollakiuria 32.21 13.32 34 213360 31496 64253842
Blood loss anaemia 32.20 13.32 4 213390 13888 64271450
Small intestinal obstruction 32.17 13.32 19 213375 23554 64261784
Swollen tongue 32.14 13.32 41 213353 34913 64250425
Enterococcal infection 32.12 13.32 4 213390 13862 64271476
Shoulder arthroplasty 31.84 13.32 42 213352 2667 64282671
Eosinophilia 31.68 13.32 48 213346 38028 64247310
Activated partial thromboplastin time prolonged 31.51 13.32 3 213391 12828 64272510
Live birth 31.48 13.32 95 213299 11109 64274229
Myelosuppression 31.42 13.32 20 213374 23810 64261528
Smear cervix abnormal 31.35 13.32 39 213355 2335 64283003
Cartilage atrophy 31.33 13.32 14 213380 159 64285179
Mental disorder 31.19 13.32 25 213369 26420 64258918
Acidosis 31.15 13.32 10 213384 17785 64267553
Prothrombin time prolonged 31.04 13.32 7 213387 15734 64269604
Epigastric discomfort 30.76 13.32 69 213325 6742 64278596
Supraventricular tachycardia 30.75 13.32 12 213382 18895 64266443
Dialysis 30.54 13.32 9 213385 16911 64268427
Full blood count abnormal 30.50 13.32 32 213362 29725 64255613
Klebsiella infection 30.36 13.32 4 213390 13277 64272061
Therapeutic product effect variable 30.15 13.32 32 213362 1612 64283726
Pulmonary tuberculosis 30.08 13.32 71 213323 7173 64278165
Lower gastrointestinal haemorrhage 30.01 13.32 5 213389 13934 64271404
Suicidal ideation 29.85 13.32 116 213278 66426 64218912
Accidental exposure to product 29.76 13.32 26 213368 26338 64259000
Vertigo 29.71 13.32 98 213296 58913 64226425
Retching 29.65 13.32 7 213387 15249 64270089
Flatulence 29.63 13.32 45 213349 35621 64249717
Mass excision 29.63 13.32 16 213378 281 64285057
Hypernatraemia 29.54 13.32 3 213391 12186 64273152
Juvenile idiopathic arthritis 29.48 13.32 49 213345 3830 64281508
Lacrimation increased 29.25 13.32 12 213382 18334 64267004
Oral discomfort 29.23 13.32 77 213317 8329 64277009
Elbow deformity 29.18 13.32 28 213366 1249 64284089
Oxygen saturation decreased 29.14 13.32 221 213173 106955 64178383
Off label use 29.04 13.32 2450 210944 630356 63654982
Vaginal haemorrhage 28.73 13.32 14 213380 19330 64266008
Cholelithiasis 28.52 13.32 68 213326 45438 64239900
Rash pruritic 28.49 13.32 303 213091 57101 64228237
Tinnitus 28.42 13.32 43 213351 34090 64251248
Stress 28.42 13.32 316 213078 60218 64225120
Decubitus ulcer 28.36 13.32 5 213389 13374 64271964
Angina unstable 28.33 13.32 8 213386 15459 64269879
Osteosclerosis 27.80 13.32 45 213349 3441 64281897
Blood magnesium decreased 27.79 13.32 6 213388 13899 64271439
Wound infection 27.74 13.32 110 213284 14754 64270584
Blood pressure systolic abnormal 27.65 13.32 84 213310 9858 64275480
Anal incontinence 27.58 13.32 8 213386 15188 64270150
Second primary malignancy 27.53 13.32 4 213390 12333 64273005
Blood triglycerides increased 27.50 13.32 14 213380 18852 64266486
Leukocytosis 27.33 13.32 52 213342 37688 64247650
Spinal meningioma benign 27.25 13.32 11 213383 95 64285243
Paranoia 27.22 13.32 10 213384 16342 64268996
Renal tubular necrosis 27.22 13.32 20 213374 22090 64263248
Nightmare 27.16 13.32 18 213376 20975 64264363
Chromaturia 27.14 13.32 21 213373 22590 64262748
Joint space narrowing 27.08 13.32 14 213380 224 64285114
Mania 27.05 13.32 10 213384 16276 64269062
Hepatitis cholestatic 26.99 13.32 4 213390 12151 64273187
Rheumatoid lung 26.95 13.32 37 213357 2442 64282896
Haemodynamic instability 26.79 13.32 8 213386 14904 64270434
Lip swelling 26.76 13.32 40 213354 31867 64253471
Hypersomnia 26.75 13.32 16 213378 19701 64265637
Hepatitis 26.69 13.32 249 213145 45333 64240005
Cyst 26.61 13.32 94 213300 11933 64273405
Hemiplegia 26.58 13.32 5 213389 12763 64272575
Hypotonia 26.55 13.32 3 213391 11209 64274129
Anaphylactic shock 26.44 13.32 37 213357 30291 64255047
Renal injury 26.43 13.32 9 213385 15420 64269918
Nocturia 26.41 13.32 3 213391 11162 64274176
Limb discomfort 26.33 13.32 167 213227 27008 64258330
Acute generalised exanthematous pustulosis 26.26 13.32 7 213387 14051 64271287
Polyuria 26.21 13.32 5 213389 12638 64272700
Osteonecrosis 26.07 13.32 33 213361 28196 64257142
Oesophagitis 26.07 13.32 20 213374 21610 64263728
Progressive multifocal leukoencephalopathy 25.88 13.32 14 213380 18218 64267120
Aplastic anaemia 25.87 13.32 7 213387 13913 64271425
Lymphopenia 25.84 13.32 28 213366 25629 64259709
Panic attack 25.74 13.32 19 213375 20934 64264404
Dementia 25.29 13.32 19 213375 20747 64264591
Stress at work 25.12 13.32 23 213371 966 64284372
Tender joint count increased 25.09 13.32 11 213383 119 64285219
Depression 25.01 13.32 441 212953 182850 64102488
Therapy interrupted 24.83 13.32 18 213376 20018 64265320
Cardiomegaly 24.81 13.32 25 213369 23659 64261679
Troponin increased 24.67 13.32 10 213384 15389 64269949
Nervous system disorder 24.58 13.32 24 213370 23054 64262284
Incontinence 24.58 13.32 5 213389 12076 64273262
Blood pressure diastolic abnormal 24.55 13.32 91 213303 11826 64273512
Iritis 24.55 13.32 40 213354 3076 64282262
Myopathy 24.48 13.32 14 213380 17666 64267672
Mycobacterium tuberculosis complex test positive 24.47 13.32 32 213362 2015 64283323
Injection site pain 24.39 13.32 243 213151 111165 64174173
Acute coronary syndrome 24.39 13.32 17 213377 19293 64266045
Liver disorder 24.36 13.32 277 213117 53074 64232264
Clostridium difficile infection 24.33 13.32 52 213342 36111 64249227
Adjustment disorder with depressed mood 24.23 13.32 35 213359 2422 64282916
Obesity 24.20 13.32 133 213261 20429 64264909
Demyelination 24.17 13.32 63 213331 6771 64278567
Apnoea 24.16 13.32 3 213391 10419 64274919
Aspergillus infection 24.10 13.32 12 213382 16367 64268971
Schizophrenia 24.06 13.32 4 213390 11164 64274174
Hallucination, auditory 24.05 13.32 13 213381 16926 64268412
Disseminated intravascular coagulation 23.92 13.32 44 213350 32304 64253034
Central nervous system lesion 23.91 13.32 5 213389 11844 64273494
Sensory disturbance 23.88 13.32 7 213387 13201 64272137
Cushingoid 23.80 13.32 67 213327 7536 64277802
Multiple fractures 23.79 13.32 58 213336 5982 64279356
Rash maculo-papular 23.74 13.32 78 213316 46948 64238390
Immune reconstitution inflammatory syndrome 23.69 13.32 6 213388 12464 64272874
Anovulatory cycle 23.59 13.32 10 213384 99 64285239
Pseudomonas infection 23.59 13.32 15 213379 17868 64267470
Arthritis bacterial 23.49 13.32 68 213326 7771 64277567
Hyperthermia 23.48 13.32 11 213383 15539 64269799
Spondyloarthropathy 23.40 13.32 20 213374 766 64284572
Lymphoproliferative disorder 23.38 13.32 52 213342 5051 64280287
Blindness 23.34 13.32 23 213371 21996 64263342
Joint dislocation 23.16 13.32 87 213307 11378 64273960
Cardiomyopathy 23.05 13.32 30 213364 25326 64260012
Thyroid disorder 23.02 13.32 88 213306 11604 64273734
COVID-19 pneumonia 22.95 13.32 13 213381 16491 64268847
Atrioventricular block first degree 22.78 13.32 4 213390 10730 64274608
Neck pain 22.72 13.32 307 213087 61226 64224112
Sleep apnoea syndrome 22.58 13.32 40 213354 29792 64255546
Bronchospasm 22.58 13.32 23 213371 21659 64263679
Anger 22.47 13.32 12 213382 15729 64269609
Mononucleosis syndrome 22.42 13.32 10 213384 113 64285225
Eyelid exfoliation 22.42 13.32 10 213384 113 64285225
Atrioventricular block 22.41 13.32 6 213388 12009 64273329
Incorrect dose administered 22.39 13.32 114 213280 60651 64224687
Erectile dysfunction 22.27 13.32 7 213387 12620 64272718
Psychomotor hyperactivity 22.17 13.32 10 213384 14441 64270897
Xyphoid retraction 22.09 13.32 11 213383 162 64285176
Hypertriglyceridaemia 22.06 13.32 5 213389 11200 64274138
Lipase increased 22.04 13.32 10 213384 14392 64270946
Inflammatory pain 21.93 13.32 20 213374 836 64284502
Weber tuning fork test abnormal 21.88 13.32 9 213385 82 64285256
Haematochezia 21.46 13.32 130 213264 66243 64219095
Bundle branch block right 21.42 13.32 4 213390 10265 64275073
Bronchopulmonary aspergillosis 21.33 13.32 19 213375 19066 64266272
Bladder transitional cell carcinoma 21.26 13.32 32 213362 2298 64283040
Electrocardiogram abnormal 21.20 13.32 9 213385 13472 64271866
Mean cell volume decreased 21.12 13.32 40 213354 3466 64281872
Urticarial vasculitis 21.11 13.32 15 213379 436 64284902
Blood lactate dehydrogenase increased 21.07 13.32 49 213345 33029 64252309
Mucosal inflammation 21.07 13.32 121 213273 62463 64222875
White blood cell count increased 20.98 13.32 130 213264 65884 64219454
Adenoiditis 20.91 13.32 7 213387 33 64285305
Anti-neutrophil cytoplasmic antibody positive vasculitis 20.88 13.32 36 213358 2900 64282438
Faeces discoloured 20.86 13.32 33 213361 25696 64259642
Effusion 20.83 13.32 29 213365 1939 64283399
Stevens-Johnson syndrome 20.82 13.32 52 213342 34197 64251141
Metastases to central nervous system 20.76 13.32 10 213384 13902 64271436
Antinuclear antibody positive 20.47 13.32 56 213338 6194 64279144
Polyglandular disorder 20.41 13.32 7 213387 36 64285302
Palpitations 20.41 13.32 234 213160 104254 64181084
Restless legs syndrome 20.41 13.32 16 213378 17100 64268238
Rotator cuff repair 20.40 13.32 25 213369 1474 64283864
Device occlusion 20.38 13.32 4 213390 9909 64275429
Crepitations 20.28 13.32 65 213329 7850 64277488
Mycobacterium marinum infection 20.25 13.32 14 213380 389 64284949
Impaired quality of life 20.23 13.32 57 213337 6414 64278924
Device difficult to use 20.05 13.32 4 213390 9794 64275544
Peritonitis bacterial 20.02 13.32 3 213391 9040 64276298
Faecaloma 19.85 13.32 4 213390 9724 64275614
Gout 19.81 13.32 25 213369 21388 64263950
Iron deficiency anaemia 19.79 13.32 26 213368 21863 64263475
Product substitution issue 19.70 13.32 18 213376 17843 64267495
Escherichia infection 19.63 13.32 13 213381 15155 64270183
Congestive cardiomyopathy 19.61 13.32 5 213389 10339 64274999
Pneumonia fungal 19.53 13.32 3 213391 8874 64276464
Tubulointerstitial nephritis 19.52 13.32 46 213348 30863 64254475
Paralysis 19.46 13.32 7 213387 11588 64273750
Upper respiratory tract infection 19.35 13.32 151 213243 72634 64212704
Intestinal ischaemia 19.33 13.32 7 213387 11542 64273796
Walking aid user 19.32 13.32 55 213339 6226 64279112
Foot operation 19.23 13.32 43 213351 4192 64281146
Hyperuricaemia 19.18 13.32 5 213389 10186 64275152
Premature delivery 19.04 13.32 20 213374 18569 64266769
Colitis microscopic 19.02 13.32 61 213333 7371 64277967
Glomerular filtration rate decreased 19.01 13.32 22 213372 19550 64265788
Urine output decreased 18.94 13.32 16 213378 16476 64268862
Gingival bleeding 18.86 13.32 13 213381 14841 64270497
Cold sweat 18.85 13.32 16 213378 16439 64268899
Extrapulmonary tuberculosis 18.72 13.32 13 213381 364 64284974
Abdominal pain lower 18.70 13.32 37 213357 26432 64258906
Lung infiltration 18.70 13.32 25 213369 20864 64264474
Personality change 18.69 13.32 3 213391 8590 64276748
Rash erythematous 18.63 13.32 90 213304 48543 64236795
Injection site reaction 18.55 13.32 236 213158 46428 64238910
Metastases to lung 18.54 13.32 14 213380 15250 64270088
Cerebral ischaemia 18.53 13.32 5 213389 9957 64275381
Skin burning sensation 18.43 13.32 6 213388 10577 64274761
Bacterial infection 18.39 13.32 34 213360 24916 64260422
Human anti-human antibody test 18.38 13.32 13 213381 375 64284963
Heparin-induced thrombocytopenia 18.35 13.32 3 213391 8476 64276862
Injection site erythema 18.31 13.32 148 213246 70652 64214686
Ecchymosis 18.17 13.32 12 213382 14010 64271328
Ureterocele 18.11 13.32 5 213389 10 64285328
Colitis ischaemic 18.04 13.32 11 213383 13403 64271935
Hypocalcaemia 17.96 13.32 74 213320 41679 64243659
Insomnia 17.84 13.32 508 212886 197328 64088010
Photosensitivity reaction 17.80 13.32 112 213282 18061 64267277
Pulseless electrical activity 17.76 13.32 10 213384 12729 64272609
Dermatitis contact 17.75 13.32 4 213390 8996 64276342
Device leakage 17.72 13.32 3 213391 8263 64277075
Feeling cold 17.69 13.32 32 213362 23646 64261692
Sacroiliitis 17.69 13.32 34 213360 2978 64282360
Spinal fusion surgery 17.63 13.32 38 213356 3613 64281725
Oral lichen planus 17.62 13.32 16 213378 665 64284673
Polyneuropathy 17.61 13.32 24 213370 19870 64265468
Pulse absent 17.59 13.32 4 213390 8942 64276396
Hypovolaemic shock 17.57 13.32 6 213388 10260 64275078
Ganglioneuroma 17.52 13.32 9 213385 142 64285196
Elbow operation 17.51 13.32 11 213383 259 64285079
Systemic inflammatory response syndrome 17.48 13.32 6 213388 10229 64275109
Respiratory disorder 17.48 13.32 61 213333 36050 64249288
Gastrointestinal pain 17.45 13.32 60 213334 7514 64277824
Gastritis 17.43 13.32 77 213317 42541 64242797
Asphyxia 17.42 13.32 5 213389 9561 64275777
Metabolic surgery 17.38 13.32 18 213376 881 64284457
Ossicle disorder 17.32 13.32 6 213388 32 64285306
Gait disturbance 17.21 13.32 715 212679 171440 64113898
Hypertensive crisis 17.20 13.32 21 213373 18227 64267111
Erythema multiforme 17.11 13.32 16 213378 15685 64269653
Cholecystitis 17.07 13.32 24 213370 19612 64265726
Appendicitis 17.06 13.32 12 213382 13557 64271781
Prostatic specific antigen increased 17.06 13.32 4 213390 8756 64276582
Hypoalbuminaemia 17.02 13.32 20 213374 17654 64267684
Post procedural haemorrhage 16.99 13.32 10 213384 12421 64272917
Abdominal tenderness 16.98 13.32 5 213389 9400 64275938
Hot flush 16.88 13.32 87 213307 46148 64239190
Immune thrombocytopenia 16.84 13.32 15 213379 15051 64270287
Cystitis haemorrhagic 16.81 13.32 3 213391 7953 64277385
Jaundice cholestatic 16.81 13.32 4 213390 8666 64276672
Aortic bruit 16.81 13.32 10 213384 213 64285125
Substance abuse 16.66 13.32 5 213389 9287 64276051
Hepatic cirrhosis 16.59 13.32 146 213248 26152 64259186
Red blood cell sedimentation rate decreased 16.40 13.32 10 213384 223 64285115
Toxic encephalopathy 16.34 13.32 6 213388 9809 64275529
Benign prostatic hyperplasia 16.31 13.32 5 213389 9160 64276178
Shoulder operation 16.24 13.32 27 213367 2111 64283227
Cardiac murmur 16.23 13.32 9 213385 11554 64273784
Transaminases increased 16.23 13.32 84 213310 44510 64240828
Diffuse idiopathic skeletal hyperostosis 16.20 13.32 6 213388 40 64285298
Dizziness postural 16.17 13.32 6 213388 9746 64275592
Pulmonary alveolar haemorrhage 16.14 13.32 6 213388 9732 64275606
Renal mass 16.13 13.32 31 213363 2716 64282622
Exercise tolerance decreased 16.09 13.32 3 213391 7707 64277631
Muscle fatigue 16.08 13.32 33 213361 3032 64282306
Investigation abnormal 16.05 13.32 21 213373 1323 64284015
Nephropathy 16.00 13.32 4 213390 8382 64276956
Hiccups 15.97 13.32 4 213390 8372 64276966
Ankle fracture 15.90 13.32 93 213301 14617 64270721
Pathogen resistance 15.90 13.32 11 213383 12532 64272806
Device malfunction 15.89 13.32 21 213373 17612 64267726
Bone tuberculosis 15.87 13.32 13 213381 469 64284869
Underdose 15.87 13.32 39 213355 25790 64259548
Brain natriuretic peptide increased 15.86 13.32 3 213391 7630 64277708
Blood pressure increased 15.83 13.32 442 212952 172110 64113228
Peripheral coldness 15.82 13.32 13 213381 13571 64271767
Gastritis erosive 15.75 13.32 6 213388 9589 64275749
Splenic embolism 15.67 13.32 9 213385 179 64285159
Pemphigoid 15.66 13.32 12 213382 12974 64272364
Glycosylated haemoglobin increased 15.56 13.32 18 213376 16001 64269337
Blood urine present 15.37 13.32 23 213371 18317 64267021
Gastric ulcer 15.36 13.32 50 213344 30184 64255154
Respiratory rate increased 15.35 13.32 23 213371 18308 64267030
Wound infection fungal 15.24 13.32 9 213385 189 64285149
Hypercholesterolaemia 15.22 13.32 95 213299 15278 64270060
Retinal haemorrhage 15.18 13.32 3 213391 7395 64277943
Acquired claw toe 15.18 13.32 7 213387 86 64285252
Intestinal obstruction 15.18 13.32 65 213329 36221 64249117
Vaginal haematoma 15.15 13.32 8 213386 134 64285204
Neuralgia 14.96 13.32 41 213353 26143 64259195
Pulmonary toxicity 14.90 13.32 62 213332 8499 64276839
Hiatus hernia 14.89 13.32 27 213367 19930 64265408
Muscle spasticity 14.87 13.32 20 213374 16649 64268689
Granuloma 14.77 13.32 52 213342 6589 64278749
Infusion site pain 14.73 13.32 8 213386 10389 64274949
General physical health deterioration 14.72 13.32 822 212572 203603 64081735
Eructation 14.67 13.32 6 213388 9185 64276153
Enterocolitis 14.63 13.32 11 213383 12007 64273331
Orthopnoea 14.52 13.32 6 213388 9128 64276210
Gardner-Diamond syndrome 14.49 13.32 4 213390 8 64285330
Polychondritis 14.49 13.32 12 213382 440 64284898
Amylase increased 14.40 13.32 7 213387 9678 64275660
Infected varicose vein 14.38 13.32 5 213389 27 64285311
Spinal X-ray abnormal 14.38 13.32 5 213389 27 64285311
Rash macular 14.37 13.32 36 213358 23649 64261689
Cholecystitis acute 14.35 13.32 10 213384 11350 64273988
Nystagmus 14.35 13.32 6 213388 9062 64276276
Dental caries 14.32 13.32 9 213385 10791 64274547
Staphylococcal sepsis 14.23 13.32 13 213381 12886 64272452
Deep vein thrombosis postoperative 14.21 13.32 20 213374 1351 64283987
Peripheral ischaemia 14.16 13.32 5 213389 8373 64276965
Caesarean section 14.14 13.32 10 213384 11264 64274074
Coronary artery stenosis 14.08 13.32 10 213384 11238 64274100
Medication error 14.07 13.32 102 213292 49864 64235474
Nail psoriasis 14.07 13.32 11 213383 371 64284967
Leukoencephalopathy 13.93 13.32 3 213391 6964 64278374
Left ventricular hypertrophy 13.93 13.32 7 213387 9499 64275839
Respiratory tract infection 13.88 13.32 70 213324 37337 64248001
Lymphadenectomy 13.86 13.32 17 213377 1003 64284335
Malignant polyp 13.80 13.32 8 213386 162 64285176
Knee deformity 13.77 13.32 16 213378 892 64284446
Sideroblastic anaemia 13.75 13.32 9 213385 228 64285110
Brain injury 13.64 13.32 8 213386 9957 64275381
Neurological symptom 13.64 13.32 3 213391 6861 64278477
Macrocytosis 13.58 13.32 27 213367 2425 64282913
Cystitis 13.58 13.32 84 213310 42591 64242747
Mean cell haemoglobin decreased 13.57 13.32 37 213357 4085 64281253
Enteritis 13.52 13.32 12 213382 12065 64273273
Acute interstitial pneumonitis 13.51 13.32 17 213377 1030 64284308
Gait inability 13.49 13.32 206 213188 42162 64243176
International normalised ratio decreased 13.45 13.32 4 213390 7474 64277864
Granulocytopenia 13.44 13.32 9 213385 10431 64274907
Metastases to lymph nodes 13.42 13.32 6 213388 8711 64276627
Eye swelling 13.41 13.32 34 213360 22247 64263091
Haemorrhoids 13.41 13.32 38 213356 23963 64261375
Fibrin D dimer increased 13.35 13.32 3 213391 6762 64278576
Bone hypertrophy 13.35 13.32 10 213384 316 64285022
Rhinitis allergic 13.35 13.32 5 213389 8073 64277265

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A07EC01 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFLAMMATORY AGENTS
Aminosalicylic acid and similar agents
FDA CS M0000971 Aminosalicylic Acids
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory agent
CHEBI has role CHEBI:35441 antiinfective agents
CHEBI has role CHEBI:55324 gastrointestinal drugs
CHEBI has role CHEBI:76797 RX:glutathione R-transferase inhibitors
CHEBI has role CHEBI:88188 allergenic drug
CHEBI has role CHEBI:173085 ferroptosis inducers
FDA EPC N0000175781 Aminosalicylate

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Ulcerative colitis indication 64766004 DOID:8577
Rheumatoid arthritis indication 69896004 DOID:7148
Juvenile rheumatoid arthritis indication 410795001
Collagenous colitis off-label use 19311003 DOID:0060183
Psoriasis with arthropathy off-label use 33339001
Crohn's disease off-label use 34000006
Systemic sclerosis off-label use 89155008 DOID:418
Urinary tract obstruction contraindication 7163005 DOID:5200
Kidney disease contraindication 90708001 DOID:557
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Gastrointestinal obstruction contraindication 126765001
Asthma contraindication 195967001 DOID:2841
Disease of liver contraindication 235856003 DOID:409
Neutropenic disorder contraindication 303011007 DOID:1227
Aplastic anemia contraindication 306058006 DOID:12449
Porphyria contraindication 418470004
Slow acetylator due to N-acetyltransferase enzyme variant contraindication 425079005




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.28 acidic
pKa2 8.93 acidic
pKa3 11.45 acidic
pKa4 1.48 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Cyclooxygenase Enzyme INHIBITOR CHEMBL CHEMBL
Arachidonate 5-lipoxygenase Enzyme INHIBITOR WOMBAT-PK CHEMBL
Carbonic anhydrase 1 Enzyme Ki 5.16 CHEMBL
Acetyl-CoA acetyltransferase, mitochondrial Enzyme WOMBAT-PK
Cystine/glutamate transporter Transporter IC50 4.52 CHEMBL
Caspase-1 Enzyme IC50 4.54 DRUG MATRIX
Thromboxane-A synthase Enzyme IC50 4.71 DRUG MATRIX
Interstitial collagenase Enzyme IC50 4.63 DRUG MATRIX
Proton-coupled folate transporter Transporter INHIBITOR IC50 4.20 IUPHAR
Mitogen-activated protein kinase 1 Kinase IC50 5.20 DRUG MATRIX
Sodium/bile acid cotransporter Transporter IC50 5.02 CHEMBL
Multidrug resistance protein 1 Transporter EC50 6.04 CHEMBL
Bifunctional purine biosynthesis protein PURH Enzyme Ki 4.66 CHEMBL
Carbonic anhydrase 2 Enzyme Ki 5.06 CHEMBL
Androgen receptor Transcription factor Ki 4.53 DRUG MATRIX
Aldose reductase Enzyme IC50 4.77 DRUG MATRIX
Replicase polyprotein 1ab Unclassified Kd 5.12 CHEMBL

External reference:

IDSource
4017897 VUID
N0000146249 NUI
D00448 KEGG_DRUG
4017897 VANDF
4019494 VANDF
C0036078 UMLSCUI
CHEBI:9334 CHEBI
CHEBI:6775 CHEBI
SAS PDB_CHEM_ID
CHEMBL421 ChEMBL_ID
D012460 MESH_DESCRIPTOR_UI
DB00795 DRUGBANK_ID
5339 PUBCHEM_CID
4840 IUPHAR_LIGAND_ID
2210 INN_ID
3XC8GUZ6CB UNII
DB00244 DRUGBANK_ID
202770 RXNORM
2061 MMSL
37855 MMSL
37856 MMSL
3946 MMSL
5056 MMSL
5528 MMSL
663 MMSL
d00379 MMSL
d01031 MMSL
001600 NDDF
002832 NDDF
387248006 SNOMEDCT_US
387501005 SNOMEDCT_US
45844004 SNOMEDCT_US
86977007 SNOMEDCT_US
4075 PUBCHEM_CID
C0127615 UMLSCUI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Azulfidine HUMAN PRESCRIPTION DRUG LABEL 1 0013-0101 TABLET 500 mg ORAL NDA 26 sections
Azulfidine EN-tabs HUMAN PRESCRIPTION DRUG LABEL 1 0013-0102 TABLET, DELAYED RELEASE 500 mg ORAL NDA 24 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 0591-0796 TABLET 500 mg ORAL ANDA 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 0591-0796 TABLET 500 mg ORAL ANDA 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 10544-288 TABLET 500 mg ORAL ANDA 29 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 23155-019 TABLET 500 mg ORAL ANDA 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 33261-756 TABLET 500 mg ORAL ANDA 29 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 43353-495 TABLET 500 mg ORAL NDA AUTHORIZED GENERIC 27 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 50090-0086 TABLET 500 mg ORAL NDA AUTHORIZED GENERIC 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 50090-2013 TABLET 500 mg ORAL ANDA 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 50090-2013 TABLET 500 mg ORAL ANDA 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 50268-730 TABLET 500 mg ORAL ANDA 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 59762-0104 TABLET, DELAYED RELEASE 500 mg ORAL NDA AUTHORIZED GENERIC 26 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 59762-5000 TABLET 500 mg ORAL NDA AUTHORIZED GENERIC 26 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 62135-960 TABLET 500 mg ORAL ANDA 14 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 63629-5688 TABLET 500 mg ORAL ANDA 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 63629-5688 TABLET 500 mg ORAL ANDA 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 68071-4215 TABLET 500 mg ORAL ANDA 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 70518-0185 TABLET 500 mg ORAL ANDA 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 70518-0185 TABLET 500 mg ORAL ANDA 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 70518-1829 TABLET 500 mg ORAL NDA authorized generic 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 70518-2342 TABLET 500 mg ORAL ANDA 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 70518-2342 TABLET 500 mg ORAL ANDA 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 71610-577 TABLET 500 mg ORAL ANDA 25 sections