Stem definition | Drug id | CAS RN |
---|---|---|
phenylazosalicylic acid derivatives antibacterial | 2525 | 599-79-1 |
Dose | Unit | Route |
---|---|---|
2 | g | O |
2 | g | R |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.00 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 1.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 167.34 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 15 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.11 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 0.26 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.00 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 7.60 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
June 20, 1950 | FDA | PHARMACIA AND UPJOHN |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug ineffective | 4889.62 | 13.85 | 11472 | 230587 | 807861 | 49555204 |
Drug intolerance | 4271.47 | 13.85 | 5236 | 236823 | 213868 | 50149197 |
Contraindicated product administered | 3076.40 | 13.85 | 3670 | 238389 | 145288 | 50217777 |
Treatment failure | 2856.05 | 13.85 | 3400 | 238659 | 134237 | 50228828 |
Joint swelling | 2439.32 | 13.85 | 4270 | 237789 | 241016 | 50122049 |
Synovitis | 2290.02 | 13.85 | 2888 | 239171 | 120977 | 50242088 |
Systemic lupus erythematosus | 1930.11 | 13.85 | 2838 | 239221 | 137784 | 50225281 |
Pemphigus | 1902.84 | 13.85 | 2597 | 239462 | 117569 | 50245496 |
Hand deformity | 1760.43 | 13.85 | 2279 | 239780 | 97920 | 50265145 |
Glossodynia | 1756.45 | 13.85 | 2449 | 239610 | 113120 | 50249945 |
Arthropathy | 1717.82 | 13.85 | 2864 | 239195 | 155042 | 50208023 |
Therapeutic product effect decreased | 1604.54 | 13.85 | 2560 | 239499 | 133490 | 50229575 |
Abdominal discomfort | 1594.86 | 13.85 | 3456 | 238603 | 228185 | 50134880 |
Alopecia | 1340.44 | 13.85 | 3341 | 238718 | 241706 | 50121359 |
Swelling | 1295.63 | 13.85 | 2921 | 239138 | 197951 | 50165114 |
Wound | 1292.51 | 13.85 | 2024 | 240035 | 103770 | 50259295 |
Anti-cyclic citrullinated peptide antibody positive | 1188.28 | 13.85 | 1573 | 240486 | 69014 | 50294051 |
Musculoskeletal stiffness | 1185.93 | 13.85 | 2169 | 239890 | 126312 | 50236753 |
Rheumatoid arthritis | 1145.22 | 13.85 | 2798 | 239261 | 199752 | 50163313 |
Pericarditis | 1070.30 | 13.85 | 1583 | 240476 | 77106 | 50285959 |
Rheumatoid factor positive | 1062.98 | 13.85 | 1251 | 240808 | 48608 | 50314457 |
Therapeutic product effect incomplete | 1033.93 | 13.85 | 1690 | 240369 | 89825 | 50273240 |
Death | 1011.72 | 13.85 | 171 | 241888 | 325208 | 50037857 |
Discomfort | 979.96 | 13.85 | 1814 | 240245 | 106566 | 50256499 |
Pain | 976.65 | 13.85 | 5380 | 236679 | 573523 | 49789542 |
Hepatic enzyme increased | 952.64 | 13.85 | 2058 | 240001 | 135322 | 50227743 |
C-reactive protein abnormal | 907.43 | 13.85 | 875 | 241184 | 26934 | 50336131 |
Drug hypersensitivity | 902.56 | 13.85 | 2943 | 239116 | 248067 | 50114998 |
Arthralgia | 835.41 | 13.85 | 4219 | 237840 | 434483 | 49928582 |
Infusion related reaction | 814.43 | 13.85 | 2204 | 239855 | 167353 | 50195712 |
Loss of personal independence in daily activities | 760.41 | 13.85 | 1271 | 240788 | 68779 | 50294286 |
Product use issue | 756.14 | 13.85 | 1981 | 240078 | 147494 | 50215571 |
Condition aggravated | 662.77 | 13.85 | 2993 | 239066 | 294065 | 50069000 |
Hypersensitivity | 656.68 | 13.85 | 2390 | 239669 | 212771 | 50150294 |
Duodenal ulcer perforation | 642.00 | 13.85 | 933 | 241126 | 44678 | 50318387 |
Psoriatic arthropathy | 608.78 | 13.85 | 925 | 241134 | 46107 | 50316958 |
Helicobacter infection | 595.12 | 13.85 | 943 | 241116 | 48759 | 50314306 |
Acute kidney injury | 590.08 | 13.85 | 179 | 241880 | 227879 | 50135186 |
Completed suicide | 584.42 | 13.85 | 9 | 242050 | 131880 | 50231185 |
Anaemia | 581.74 | 13.85 | 240 | 241819 | 252216 | 50110849 |
Red blood cell sedimentation rate increased | 578.96 | 13.85 | 709 | 241350 | 28707 | 50334358 |
Rash | 541.26 | 13.85 | 3759 | 238300 | 433712 | 49929353 |
Maternal exposure during pregnancy | 536.26 | 13.85 | 1832 | 240227 | 157946 | 50205119 |
Hypotension | 531.01 | 13.85 | 231 | 241828 | 235238 | 50127827 |
Red blood cell sedimentation rate abnormal | 515.69 | 13.85 | 505 | 241554 | 15838 | 50347227 |
C-reactive protein increased | 512.67 | 13.85 | 1041 | 241018 | 65433 | 50297632 |
Toxicity to various agents | 489.43 | 13.85 | 202 | 241857 | 212297 | 50150768 |
Constipation | 478.00 | 13.85 | 147 | 241912 | 185561 | 50177504 |
Drug interaction | 460.92 | 13.85 | 189 | 241870 | 199432 | 50163633 |
Dyspnoea | 445.56 | 13.85 | 1254 | 240805 | 546354 | 49816711 |
Sleep disorder due to general medical condition, insomnia type | 443.47 | 13.85 | 644 | 241415 | 30803 | 50332262 |
Dehydration | 427.39 | 13.85 | 102 | 241957 | 152347 | 50210718 |
Bone erosion | 421.78 | 13.85 | 389 | 241670 | 11298 | 50351767 |
Asthenia | 415.73 | 13.85 | 551 | 241508 | 318491 | 50044574 |
Fall | 385.10 | 13.85 | 631 | 241428 | 334301 | 50028764 |
Seizure | 358.92 | 13.85 | 65 | 241994 | 117809 | 50245256 |
Blood iron abnormal | 355.60 | 13.85 | 213 | 241846 | 3113 | 50359952 |
Thrombocytopenia | 347.02 | 13.85 | 91 | 241968 | 127582 | 50235483 |
Anxiety | 342.72 | 13.85 | 213 | 241846 | 177393 | 50185672 |
Tremor | 331.74 | 13.85 | 72 | 241987 | 114831 | 50248234 |
Febrile neutropenia | 329.24 | 13.85 | 40 | 242019 | 97627 | 50265438 |
Dizziness | 321.29 | 13.85 | 741 | 241318 | 345628 | 50017437 |
Product dose omission issue | 319.54 | 13.85 | 247 | 241812 | 183591 | 50179474 |
Peripheral swelling | 316.64 | 13.85 | 1872 | 240187 | 204064 | 50159001 |
Knee arthroplasty | 315.89 | 13.85 | 594 | 241465 | 35252 | 50327813 |
Rheumatoid nodule | 305.69 | 13.85 | 340 | 241719 | 12395 | 50350670 |
Disability | 304.82 | 13.85 | 340 | 241719 | 12435 | 50350630 |
Inflammation | 304.39 | 13.85 | 771 | 241288 | 56141 | 50306924 |
Cardiac arrest | 297.95 | 13.85 | 28 | 242031 | 83623 | 50279442 |
Mobility decreased | 292.99 | 13.85 | 945 | 241114 | 79003 | 50284062 |
Infection | 291.22 | 13.85 | 1611 | 240448 | 171343 | 50191722 |
Diarrhoea | 288.52 | 13.85 | 1646 | 240413 | 586830 | 49776235 |
Hyponatraemia | 286.29 | 13.85 | 56 | 242003 | 96083 | 50266982 |
Malignant neoplasm progression | 281.22 | 13.85 | 10 | 242049 | 68114 | 50294951 |
Intentional overdose | 277.90 | 13.85 | 4 | 242055 | 62500 | 50300565 |
Oedema peripheral | 277.31 | 13.85 | 210 | 241849 | 157751 | 50205314 |
Hip arthroplasty | 274.05 | 13.85 | 509 | 241550 | 29920 | 50333145 |
Neutropenia | 267.14 | 13.85 | 191 | 241868 | 147774 | 50215291 |
Somnolence | 264.52 | 13.85 | 212 | 241847 | 154773 | 50208292 |
Grip strength decreased | 262.81 | 13.85 | 307 | 241752 | 11814 | 50351251 |
Atrial fibrillation | 258.98 | 13.85 | 82 | 241977 | 101663 | 50261402 |
Tachycardia | 258.25 | 13.85 | 78 | 241981 | 99685 | 50263380 |
Drug abuse | 257.23 | 13.85 | 6 | 242053 | 59840 | 50303225 |
Blood parathyroid hormone decreased | 255.16 | 13.85 | 236 | 241823 | 6878 | 50356187 |
Granuloma skin | 252.48 | 13.85 | 215 | 241844 | 5603 | 50357462 |
Cardiac failure congestive | 247.38 | 13.85 | 51 | 242008 | 84331 | 50278734 |
Panniculitis | 246.56 | 13.85 | 251 | 241808 | 8252 | 50354813 |
Urinary tract infection | 246.14 | 13.85 | 434 | 241625 | 223586 | 50139479 |
Platelet count decreased | 236.14 | 13.85 | 93 | 241966 | 100633 | 50262432 |
Rheumatic fever | 232.78 | 13.85 | 342 | 241717 | 16525 | 50346540 |
Swollen joint count increased | 232.44 | 13.85 | 320 | 241739 | 14553 | 50348512 |
Balance disorder | 225.79 | 13.85 | 34 | 242025 | 70556 | 50292509 |
Bradycardia | 220.54 | 13.85 | 25 | 242034 | 64401 | 50298664 |
Cardio-respiratory arrest | 218.72 | 13.85 | 9 | 242050 | 53883 | 50309182 |
Gastrointestinal haemorrhage | 217.66 | 13.85 | 43 | 242016 | 73278 | 50289787 |
Osteoarthritis | 216.14 | 13.85 | 771 | 241288 | 67835 | 50295230 |
Muscle injury | 215.57 | 13.85 | 519 | 241540 | 36592 | 50326473 |
Drug tolerance decreased | 215.47 | 13.85 | 242 | 241817 | 8918 | 50354147 |
Hypokalaemia | 211.65 | 13.85 | 78 | 241981 | 87914 | 50275151 |
Hyperkalaemia | 209.92 | 13.85 | 4 | 242055 | 48085 | 50314980 |
Renal failure | 209.59 | 13.85 | 125 | 241934 | 106508 | 50256557 |
Electrocardiogram QT prolonged | 209.45 | 13.85 | 9 | 242050 | 51877 | 50311188 |
Respiratory failure | 209.15 | 13.85 | 87 | 241972 | 91094 | 50271971 |
Pulmonary embolism | 208.81 | 13.85 | 113 | 241946 | 101591 | 50261474 |
Gastrointestinal disorder | 206.88 | 13.85 | 948 | 241111 | 93508 | 50269557 |
Irritable bowel syndrome | 205.84 | 13.85 | 627 | 241432 | 50814 | 50312251 |
Cerebrovascular accident | 205.14 | 13.85 | 98 | 241961 | 94582 | 50268483 |
Folliculitis | 205.13 | 13.85 | 527 | 241532 | 38698 | 50324367 |
Overdose | 201.56 | 13.85 | 113 | 241946 | 99614 | 50263451 |
Disease progression | 199.03 | 13.85 | 105 | 241954 | 95761 | 50267304 |
Transplant dysfunction | 196.96 | 13.85 | 170 | 241889 | 4514 | 50358551 |
Chest pain | 193.01 | 13.85 | 344 | 241715 | 176538 | 50186527 |
Deformity | 188.87 | 13.85 | 211 | 241848 | 7729 | 50355336 |
Hypoglycaemia | 187.97 | 13.85 | 19 | 242040 | 53562 | 50309503 |
Depressed level of consciousness | 186.02 | 13.85 | 17 | 242042 | 51936 | 50311129 |
Decreased appetite | 185.82 | 13.85 | 430 | 241629 | 200493 | 50162572 |
Ankylosing spondylitis | 185.36 | 13.85 | 199 | 241860 | 6966 | 50356099 |
Joint stiffness | 184.84 | 13.85 | 432 | 241627 | 29876 | 50333189 |
Vision blurred | 182.05 | 13.85 | 74 | 241985 | 78573 | 50284492 |
Multiple sclerosis relapse | 182.01 | 13.85 | 5 | 242054 | 42959 | 50320106 |
Suicide attempt | 177.25 | 13.85 | 20 | 242039 | 51712 | 50311353 |
Paraesthesia | 177.25 | 13.85 | 188 | 241871 | 120055 | 50243010 |
Muscle spasms | 174.46 | 13.85 | 206 | 241853 | 125347 | 50237718 |
Vomiting | 171.84 | 13.85 | 1396 | 240663 | 459362 | 49903703 |
Chest discomfort | 170.83 | 13.85 | 117 | 241942 | 92605 | 50270460 |
Joint destruction | 170.51 | 13.85 | 145 | 241914 | 3771 | 50359294 |
Arthritis | 169.29 | 13.85 | 842 | 241217 | 85879 | 50277186 |
Dysphagia | 168.28 | 13.85 | 80 | 241979 | 77438 | 50285627 |
Agitation | 167.80 | 13.85 | 27 | 242032 | 53357 | 50309708 |
Skin necrosis | 167.09 | 13.85 | 232 | 241827 | 10635 | 50352430 |
Sepsis | 166.25 | 13.85 | 236 | 241823 | 132689 | 50230376 |
Cardiac failure | 165.80 | 13.85 | 78 | 241981 | 75962 | 50287103 |
Coma | 165.41 | 13.85 | 35 | 242024 | 56844 | 50306221 |
Syncope | 162.18 | 13.85 | 152 | 241907 | 102850 | 50260215 |
Cognitive disorder | 161.90 | 13.85 | 13 | 242046 | 44110 | 50318955 |
Blister | 158.76 | 13.85 | 818 | 241241 | 84600 | 50278465 |
Fluid retention | 158.34 | 13.85 | 26 | 242033 | 50623 | 50312442 |
Hypoxia | 155.95 | 13.85 | 28 | 242031 | 51095 | 50311970 |
Musculoskeletal deformity | 154.67 | 13.85 | 81 | 241978 | 897 | 50362168 |
Myalgia | 154.20 | 13.85 | 222 | 241837 | 124097 | 50238968 |
Epistaxis | 153.27 | 13.85 | 57 | 242002 | 63897 | 50299168 |
Enthesopathy | 152.30 | 13.85 | 180 | 241879 | 7013 | 50356052 |
International normalised ratio increased | 152.16 | 13.85 | 15 | 242044 | 43137 | 50319928 |
White blood cell count decreased | 149.19 | 13.85 | 204 | 241855 | 116518 | 50246547 |
Rhabdomyolysis | 147.47 | 13.85 | 10 | 242049 | 39017 | 50324048 |
Abdominal pain | 146.33 | 13.85 | 607 | 241452 | 235621 | 50127444 |
Wrong technique in product usage process | 146.18 | 13.85 | 42 | 242017 | 55468 | 50307597 |
Cough | 145.71 | 13.85 | 626 | 241433 | 240638 | 50122427 |
Impaired healing | 142.20 | 13.85 | 686 | 241373 | 69100 | 50293965 |
Musculoskeletal pain | 140.99 | 13.85 | 701 | 241358 | 71476 | 50291589 |
Mental status changes | 140.94 | 13.85 | 8 | 242051 | 36264 | 50326801 |
Lactic acidosis | 140.85 | 13.85 | 4 | 242055 | 33351 | 50329714 |
Dysarthria | 140.13 | 13.85 | 10 | 242049 | 37393 | 50325672 |
Drug eruption | 138.00 | 13.85 | 331 | 241728 | 23275 | 50339790 |
Fatigue | 135.88 | 13.85 | 4380 | 237679 | 703221 | 49659844 |
Blood glucose increased | 135.42 | 13.85 | 87 | 241972 | 71237 | 50291828 |
Haemoglobin decreased | 134.61 | 13.85 | 252 | 241807 | 126964 | 50236101 |
Disorientation | 134.35 | 13.85 | 9 | 242050 | 35475 | 50327590 |
Hallucination | 133.05 | 13.85 | 30 | 242029 | 46627 | 50316438 |
Metabolic acidosis | 133.03 | 13.85 | 15 | 242044 | 38810 | 50324255 |
Hyperglycaemia | 130.09 | 13.85 | 12 | 242047 | 36393 | 50326672 |
Type 2 diabetes mellitus | 130.08 | 13.85 | 411 | 241648 | 33964 | 50329101 |
Multiple organ dysfunction syndrome | 129.06 | 13.85 | 40 | 242019 | 50297 | 50312768 |
Pulmonary oedema | 128.91 | 13.85 | 37 | 242022 | 48901 | 50314164 |
Unresponsive to stimuli | 128.05 | 13.85 | 4 | 242055 | 30605 | 50332460 |
Foot deformity | 127.31 | 13.85 | 283 | 241776 | 18927 | 50344138 |
Blood cholesterol increased | 126.68 | 13.85 | 562 | 241497 | 54653 | 50308412 |
Polyarthritis | 126.03 | 13.85 | 172 | 241887 | 7755 | 50355310 |
Musculoskeletal disorder | 125.74 | 13.85 | 265 | 241794 | 17084 | 50345981 |
Tenosynovitis | 125.71 | 13.85 | 200 | 241859 | 10365 | 50352700 |
Neoplasm progression | 124.99 | 13.85 | 3 | 242056 | 29154 | 50333911 |
Adverse event | 124.51 | 13.85 | 476 | 241583 | 43287 | 50319778 |
Liver function test increased | 122.64 | 13.85 | 333 | 241726 | 25273 | 50337792 |
Breast cancer stage III | 122.59 | 13.85 | 111 | 241948 | 3145 | 50359920 |
Hyperhidrosis | 121.78 | 13.85 | 149 | 241910 | 89277 | 50273788 |
Encephalopathy | 120.76 | 13.85 | 11 | 242048 | 33700 | 50329365 |
Ill-defined disorder | 119.93 | 13.85 | 549 | 241510 | 54105 | 50308960 |
Ulcer | 117.82 | 13.85 | 283 | 241776 | 19917 | 50343148 |
Body height below normal | 116.65 | 13.85 | 87 | 241972 | 1862 | 50361203 |
Weight decreased | 115.97 | 13.85 | 604 | 241455 | 220641 | 50142424 |
Respiratory arrest | 115.44 | 13.85 | 7 | 242052 | 30002 | 50333063 |
Red blood cell sedimentation rate | 115.32 | 13.85 | 112 | 241947 | 3474 | 50359591 |
Physical disability | 114.03 | 13.85 | 84 | 241975 | 1763 | 50361302 |
Intentional product use issue | 113.29 | 13.85 | 692 | 241367 | 76226 | 50286839 |
Dysgeusia | 113.04 | 13.85 | 24 | 242035 | 38892 | 50324173 |
Sedation | 112.35 | 13.85 | 9 | 242050 | 30601 | 50332464 |
Human antichimeric antibody positive | 111.06 | 13.85 | 76 | 241983 | 1413 | 50361652 |
Product quality issue | 110.72 | 13.85 | 10 | 242049 | 30848 | 50332217 |
Neutrophil count decreased | 110.31 | 13.85 | 41 | 242018 | 45985 | 50317080 |
Haemorrhage | 110.20 | 13.85 | 59 | 242000 | 53382 | 50309683 |
Gastrooesophageal reflux disease | 109.81 | 13.85 | 122 | 241937 | 76306 | 50286759 |
Seronegative arthritis | 107.99 | 13.85 | 85 | 241974 | 1976 | 50361089 |
Hypervolaemia | 107.88 | 13.85 | 3 | 242056 | 25496 | 50337569 |
Pulmonary hypertension | 104.79 | 13.85 | 17 | 242042 | 33400 | 50329665 |
Asthma | 104.50 | 13.85 | 166 | 241893 | 89171 | 50273894 |
Chronic obstructive pulmonary disease | 104.44 | 13.85 | 63 | 241996 | 53372 | 50309693 |
Acute respiratory failure | 104.16 | 13.85 | 9 | 242050 | 28773 | 50334292 |
Respiratory distress | 103.90 | 13.85 | 12 | 242047 | 30477 | 50332588 |
Plasma cell myeloma | 102.68 | 13.85 | 14 | 242045 | 31308 | 50331757 |
Feeling abnormal | 102.44 | 13.85 | 286 | 241773 | 125206 | 50237859 |
Injection site pain | 102.22 | 13.85 | 238 | 241821 | 110786 | 50252279 |
Flushing | 101.85 | 13.85 | 102 | 241957 | 66913 | 50296152 |
Blood potassium decreased | 100.94 | 13.85 | 26 | 242033 | 36919 | 50326146 |
Sciatica | 100.33 | 13.85 | 276 | 241783 | 21106 | 50341959 |
Pancytopenia | 100.33 | 13.85 | 154 | 241905 | 83876 | 50279189 |
Chills | 100.09 | 13.85 | 194 | 241865 | 96493 | 50266572 |
Hepatic failure | 97.77 | 13.85 | 18 | 242041 | 32265 | 50330800 |
Dyskinesia | 97.40 | 13.85 | 10 | 242049 | 27851 | 50335214 |
Myocardial infarction | 97.14 | 13.85 | 173 | 241886 | 88854 | 50274211 |
Transplant rejection | 97.04 | 13.85 | 169 | 241890 | 9440 | 50353625 |
Drug withdrawal syndrome | 96.02 | 13.85 | 6 | 242053 | 25075 | 50337990 |
Adverse drug reaction | 95.82 | 13.85 | 519 | 241540 | 54703 | 50308362 |
Pleural effusion | 95.61 | 13.85 | 151 | 241908 | 81303 | 50281762 |
Basal cell carcinoma | 95.57 | 13.85 | 287 | 241772 | 23069 | 50339996 |
X-ray abnormal | 95.14 | 13.85 | 88 | 241971 | 2564 | 50360501 |
Irritability | 94.87 | 13.85 | 12 | 242047 | 28414 | 50334651 |
Serotonin syndrome | 94.35 | 13.85 | 6 | 242053 | 24707 | 50338358 |
Lethargy | 94.23 | 13.85 | 60 | 241999 | 49372 | 50313693 |
Onychomycosis | 93.49 | 13.85 | 118 | 241941 | 4924 | 50358141 |
Hospitalisation | 92.69 | 13.85 | 113 | 241946 | 67824 | 50295241 |
Blood pressure decreased | 92.17 | 13.85 | 79 | 241980 | 55830 | 50307235 |
Pneumonia | 92.07 | 13.85 | 1266 | 240793 | 377135 | 49985930 |
Hypophagia | 91.83 | 13.85 | 12 | 242047 | 27716 | 50335349 |
Depression | 91.55 | 13.85 | 443 | 241616 | 164980 | 50198085 |
Intentional product misuse | 91.48 | 13.85 | 55 | 242004 | 46679 | 50316386 |
COVID-19 | 91.22 | 13.85 | 55 | 242004 | 46607 | 50316458 |
Restlessness | 90.74 | 13.85 | 8 | 242051 | 25165 | 50337900 |
Pyrexia | 90.37 | 13.85 | 1278 | 240781 | 378925 | 49984140 |
Pneumonia aspiration | 90.29 | 13.85 | 19 | 242040 | 30985 | 50332080 |
Dry skin | 90.06 | 13.85 | 47 | 242012 | 43144 | 50319921 |
Wheelchair user | 90.04 | 13.85 | 115 | 241944 | 4857 | 50358208 |
Therapeutic response decreased | 89.58 | 13.85 | 455 | 241604 | 46776 | 50316289 |
Transient ischaemic attack | 89.29 | 13.85 | 22 | 242037 | 32188 | 50330877 |
Dislocation of vertebra | 89.26 | 13.85 | 91 | 241968 | 2996 | 50360069 |
Back pain | 89.07 | 13.85 | 651 | 241408 | 219379 | 50143686 |
Disturbance in attention | 89.02 | 13.85 | 20 | 242039 | 31166 | 50331899 |
Joint range of motion decreased | 88.90 | 13.85 | 241 | 241818 | 18271 | 50344794 |
Memory impairment | 87.68 | 13.85 | 153 | 241906 | 79207 | 50283858 |
Dyspnoea exertional | 87.41 | 13.85 | 70 | 241989 | 51163 | 50311902 |
Skin ulcer | 85.98 | 13.85 | 366 | 241693 | 34952 | 50328113 |
Blood bilirubin increased | 84.79 | 13.85 | 24 | 242035 | 32014 | 50331051 |
Ovarian cyst | 84.77 | 13.85 | 199 | 241860 | 13797 | 50349268 |
Hypomagnesaemia | 84.45 | 13.85 | 7 | 242052 | 23149 | 50339916 |
Cerebral haemorrhage | 84.29 | 13.85 | 14 | 242045 | 27038 | 50336027 |
Haematoma | 84.26 | 13.85 | 21 | 242038 | 30489 | 50332576 |
Ascites | 84.18 | 13.85 | 33 | 242026 | 35828 | 50327237 |
Dysuria | 83.98 | 13.85 | 17 | 242042 | 28487 | 50334578 |
Aphasia | 83.94 | 13.85 | 17 | 242042 | 28477 | 50334588 |
Deep vein thrombosis | 83.11 | 13.85 | 139 | 241920 | 73165 | 50289900 |
Muscular weakness | 81.70 | 13.85 | 211 | 241848 | 94802 | 50268263 |
Antibody test positive | 81.59 | 13.85 | 76 | 241983 | 2235 | 50360830 |
Lower respiratory tract infection | 81.28 | 13.85 | 753 | 241306 | 94448 | 50268617 |
Chronic kidney disease | 80.41 | 13.85 | 45 | 242014 | 39726 | 50323339 |
Accidental overdose | 80.13 | 13.85 | 3 | 242056 | 19530 | 50343535 |
Vascular access complication | 80.07 | 13.85 | 56 | 242003 | 1080 | 50361985 |
Bone pain | 79.99 | 13.85 | 65 | 241994 | 47164 | 50315901 |
Red cell distribution width decreased | 79.12 | 13.85 | 55 | 242004 | 1050 | 50362015 |
Generalised tonic-clonic seizure | 78.97 | 13.85 | 15 | 242044 | 26295 | 50336770 |
Fear of injection | 78.84 | 13.85 | 120 | 241939 | 5983 | 50357082 |
Joint effusion | 78.72 | 13.85 | 185 | 241874 | 12836 | 50350229 |
Urinary incontinence | 78.71 | 13.85 | 19 | 242040 | 28189 | 50334876 |
Stomatitis | 78.34 | 13.85 | 785 | 241274 | 100559 | 50262506 |
Orthostatic hypotension | 78.17 | 13.85 | 22 | 242037 | 29459 | 50333606 |
Full blood count decreased | 78.17 | 13.85 | 8 | 242051 | 22338 | 50340727 |
Osteonecrosis of jaw | 77.90 | 13.85 | 29 | 242030 | 32497 | 50330568 |
Abdominal distension | 77.44 | 13.85 | 144 | 241915 | 72759 | 50290306 |
Finger deformity | 76.64 | 13.85 | 114 | 241945 | 5568 | 50357497 |
Neuropathy peripheral | 76.38 | 13.85 | 224 | 241835 | 96533 | 50266532 |
General physical health deterioration | 76.02 | 13.85 | 1027 | 241032 | 141407 | 50221658 |
Nausea | 75.56 | 13.85 | 2690 | 239369 | 702708 | 49660357 |
Aggression | 75.34 | 13.85 | 7 | 242052 | 21109 | 50341956 |
Arrhythmia | 75.32 | 13.85 | 32 | 242027 | 33100 | 50329965 |
Device dislocation | 74.63 | 13.85 | 8 | 242051 | 21538 | 50341527 |
Blood pressure increased | 74.53 | 13.85 | 355 | 241704 | 132777 | 50230288 |
Pulmonary arterial hypertension | 74.50 | 13.85 | 6 | 242053 | 20313 | 50342752 |
Urinary retention | 74.35 | 13.85 | 17 | 242042 | 26173 | 50336892 |
Blood urea increased | 73.95 | 13.85 | 12 | 242047 | 23573 | 50339492 |
Melaena | 73.21 | 13.85 | 19 | 242040 | 26845 | 50336220 |
Blood creatine phosphokinase increased | 73.10 | 13.85 | 18 | 242041 | 26349 | 50336716 |
Ejection fraction decreased | 72.21 | 13.85 | 4 | 242055 | 18516 | 50344549 |
Injection site erythema | 71.92 | 13.85 | 157 | 241902 | 74779 | 50288286 |
Altered state of consciousness | 71.33 | 13.85 | 10 | 242049 | 21900 | 50341165 |
Nail disorder | 71.17 | 13.85 | 149 | 241910 | 9559 | 50353506 |
Exostosis | 70.92 | 13.85 | 166 | 241893 | 11487 | 50351578 |
Rheumatoid factor negative | 70.90 | 13.85 | 41 | 242018 | 559 | 50362506 |
Fibromyalgia | 70.26 | 13.85 | 411 | 241648 | 44567 | 50318498 |
Upper respiratory tract infection | 70.14 | 13.85 | 130 | 241929 | 65768 | 50297297 |
Hip fracture | 69.41 | 13.85 | 19 | 242040 | 25912 | 50337153 |
Lymphocyte count decreased | 69.07 | 13.85 | 20 | 242039 | 26287 | 50336778 |
Hypercalcaemia | 68.06 | 13.85 | 256 | 241803 | 23096 | 50339969 |
Blood sodium decreased | 68.03 | 13.85 | 10 | 242049 | 21137 | 50341928 |
Mean platelet volume decreased | 67.83 | 13.85 | 59 | 242000 | 1583 | 50361482 |
Vaginal haemorrhage | 67.60 | 13.85 | 17 | 242042 | 24534 | 50338531 |
Tenderness | 67.52 | 13.85 | 219 | 241840 | 18346 | 50344719 |
Coronary artery disease | 67.11 | 13.85 | 29 | 242030 | 29697 | 50333368 |
Metastases to bone | 66.86 | 13.85 | 5 | 242054 | 17990 | 50345075 |
Haematuria | 66.29 | 13.85 | 20 | 242039 | 25593 | 50337472 |
Infusion site reaction | 65.56 | 13.85 | 66 | 241993 | 2140 | 50360925 |
Product label confusion | 65.31 | 13.85 | 37 | 242022 | 484 | 50362581 |
Presbyacusis | 64.70 | 13.85 | 73 | 241986 | 2703 | 50360362 |
Foetal exposure during pregnancy | 64.51 | 13.85 | 25 | 242034 | 27334 | 50335731 |
Throat irritation | 64.40 | 13.85 | 32 | 242027 | 30207 | 50332858 |
Psychotic disorder | 64.28 | 13.85 | 13 | 242046 | 21799 | 50341266 |
Cellulitis | 64.16 | 13.85 | 153 | 241906 | 70645 | 50292420 |
Rectal haemorrhage | 64.14 | 13.85 | 54 | 242005 | 38504 | 50324561 |
Pleural thickening | 63.42 | 13.85 | 70 | 241989 | 2529 | 50360536 |
Epilepsy | 63.25 | 13.85 | 13 | 242046 | 21554 | 50341511 |
Emotional distress | 63.08 | 13.85 | 29 | 242030 | 28634 | 50334431 |
Abortion spontaneous | 62.98 | 13.85 | 64 | 241995 | 41708 | 50321357 |
Impaired work ability | 62.93 | 13.85 | 175 | 241884 | 13465 | 50349600 |
Skin exfoliation | 62.43 | 13.85 | 42 | 242017 | 33570 | 50329495 |
Sinus tachycardia | 62.36 | 13.85 | 13 | 242046 | 21341 | 50341724 |
International normalised ratio fluctuation | 62.31 | 13.85 | 64 | 241995 | 2126 | 50360939 |
Acute myocardial infarction | 62.30 | 13.85 | 31 | 242028 | 29242 | 50333823 |
Obstructive airways disorder | 62.23 | 13.85 | 3 | 242056 | 15649 | 50347416 |
Pallor | 62.09 | 13.85 | 17 | 242042 | 23182 | 50339883 |
Accidental exposure to product | 61.52 | 13.85 | 17 | 242042 | 23040 | 50340025 |
Coeliac disease | 61.01 | 13.85 | 131 | 241928 | 8554 | 50354511 |
Nervousness | 60.81 | 13.85 | 28 | 242031 | 27623 | 50335442 |
Device issue | 60.77 | 13.85 | 11 | 242048 | 19961 | 50343104 |
Electrolyte imbalance | 60.44 | 13.85 | 6 | 242053 | 17163 | 50345902 |
Clostridium difficile colitis | 60.41 | 13.85 | 7 | 242052 | 17735 | 50345330 |
Palpitations | 60.19 | 13.85 | 240 | 241819 | 94266 | 50268799 |
Drug level increased | 59.97 | 13.85 | 10 | 242049 | 19258 | 50343807 |
Head injury | 59.95 | 13.85 | 20 | 242039 | 24000 | 50339065 |
Incorrect dose administered | 59.45 | 13.85 | 87 | 241972 | 48327 | 50314738 |
Therapy cessation | 59.32 | 13.85 | 25 | 242034 | 25986 | 50337079 |
Cardiac disorder | 58.08 | 13.85 | 72 | 241987 | 42907 | 50320158 |
Interstitial lung disease | 57.78 | 13.85 | 444 | 241615 | 52732 | 50310333 |
Diplopia | 57.76 | 13.85 | 11 | 242048 | 19249 | 50343816 |
Ischaemic stroke | 57.67 | 13.85 | 5 | 242054 | 15943 | 50347122 |
Bone density abnormal | 57.63 | 13.85 | 72 | 241987 | 2973 | 50360092 |
Withdrawal syndrome | 57.33 | 13.85 | 8 | 242051 | 17582 | 50345483 |
Ventricular tachycardia | 57.10 | 13.85 | 5 | 242054 | 15816 | 50347249 |
Pleural fibrosis | 56.19 | 13.85 | 75 | 241984 | 3309 | 50359756 |
Depressed mood | 56.16 | 13.85 | 48 | 242011 | 33975 | 50329090 |
Dactylitis | 55.90 | 13.85 | 56 | 242003 | 1805 | 50361260 |
Pollakiuria | 55.89 | 13.85 | 22 | 242037 | 23829 | 50339236 |
Insomnia | 55.61 | 13.85 | 551 | 241508 | 174314 | 50188751 |
Muscle twitching | 55.36 | 13.85 | 5 | 242054 | 15426 | 50347639 |
Right ventricular failure | 54.80 | 13.85 | 6 | 242053 | 15887 | 50347178 |
Bone marrow failure | 54.78 | 13.85 | 32 | 242027 | 27592 | 50335473 |
Mycotic allergy | 54.55 | 13.85 | 39 | 242020 | 780 | 50362285 |
Vertigo | 54.50 | 13.85 | 103 | 241956 | 51729 | 50311336 |
Adverse reaction | 54.11 | 13.85 | 124 | 241935 | 8462 | 50354603 |
White blood cell count abnormal | 54.05 | 13.85 | 95 | 241964 | 5345 | 50357720 |
Arthrodesis | 53.96 | 13.85 | 63 | 241996 | 2422 | 50360643 |
Oxygen saturation decreased | 53.95 | 13.85 | 175 | 241884 | 73073 | 50289992 |
Myoclonus | 53.82 | 13.85 | 4 | 242055 | 14466 | 50348599 |
Product administration error | 53.55 | 13.85 | 14 | 242045 | 19685 | 50343380 |
Confusional state | 53.39 | 13.85 | 600 | 241459 | 185328 | 50177737 |
Jaundice | 53.29 | 13.85 | 30 | 242029 | 26399 | 50336666 |
Acne | 53.16 | 13.85 | 210 | 241849 | 19385 | 50343680 |
Hypoaesthesia | 53.14 | 13.85 | 373 | 241686 | 126884 | 50236181 |
Drug specific antibody | 53.14 | 13.85 | 54 | 242005 | 1771 | 50361294 |
Cholelithiasis | 53.02 | 13.85 | 62 | 241997 | 37911 | 50325154 |
Upper gastrointestinal haemorrhage | 52.95 | 13.85 | 7 | 242052 | 16028 | 50347037 |
Mean cell volume decreased | 52.72 | 13.85 | 64 | 241995 | 2565 | 50360500 |
Blood alkaline phosphatase increased | 52.69 | 13.85 | 61 | 241998 | 37465 | 50325600 |
Hot flush | 52.65 | 13.85 | 81 | 241978 | 44088 | 50318977 |
Pancreatitis acute | 52.54 | 13.85 | 24 | 242035 | 23788 | 50339277 |
Coagulopathy | 52.24 | 13.85 | 11 | 242048 | 17933 | 50345132 |
Urticaria | 52.05 | 13.85 | 384 | 241675 | 129177 | 50233888 |
Status epilepticus | 51.95 | 13.85 | 3 | 242056 | 13403 | 50349662 |
Speech disorder | 51.87 | 13.85 | 56 | 242003 | 35492 | 50327573 |
Premature baby | 51.85 | 13.85 | 12 | 242047 | 18325 | 50344740 |
Dermatitis allergic | 51.74 | 13.85 | 156 | 241903 | 12564 | 50350501 |
Visual acuity reduced | 51.62 | 13.85 | 16 | 242043 | 20123 | 50342942 |
Neck deformity | 51.27 | 13.85 | 55 | 242004 | 1923 | 50361142 |
Loss of consciousness | 51.22 | 13.85 | 291 | 241768 | 104062 | 50259003 |
Angina pectoris | 50.99 | 13.85 | 31 | 242028 | 26157 | 50336908 |
Sinus bradycardia | 50.93 | 13.85 | 3 | 242056 | 13180 | 50349885 |
Drug ineffective for unapproved indication | 50.92 | 13.85 | 19 | 242040 | 21262 | 50341803 |
Premature delivery | 50.45 | 13.85 | 25 | 242034 | 23638 | 50339427 |
Mental disorder | 50.37 | 13.85 | 21 | 242038 | 21970 | 50341095 |
Pulmonary fibrosis | 50.30 | 13.85 | 241 | 241818 | 24196 | 50338869 |
Swollen tongue | 50.25 | 13.85 | 38 | 242021 | 28592 | 50334473 |
Wrist deformity | 49.91 | 13.85 | 52 | 242007 | 1757 | 50361308 |
Blood magnesium increased | 49.63 | 13.85 | 65 | 241994 | 2815 | 50360250 |
Pulmonary congestion | 49.54 | 13.85 | 7 | 242052 | 15240 | 50347825 |
Fine motor skill dysfunction | 49.26 | 13.85 | 78 | 241981 | 4025 | 50359040 |
Onychomadesis | 49.22 | 13.85 | 72 | 241987 | 3464 | 50359601 |
Bone swelling | 49.03 | 13.85 | 43 | 242016 | 1167 | 50361898 |
Headache | 48.86 | 13.85 | 1955 | 240104 | 504580 | 49858485 |
Oral discomfort | 48.56 | 13.85 | 114 | 241945 | 7903 | 50355162 |
Shock | 48.47 | 13.85 | 19 | 242040 | 20631 | 50342434 |
Lacrimation increased | 48.29 | 13.85 | 11 | 242048 | 16981 | 50346084 |
Posterior reversible encephalopathy syndrome | 48.16 | 13.85 | 7 | 242052 | 14921 | 50348144 |
Bloody discharge | 48.13 | 13.85 | 42 | 242017 | 1132 | 50361933 |
Retinitis | 48.09 | 13.85 | 52 | 242007 | 1835 | 50361230 |
Extremity contracture | 47.88 | 13.85 | 43 | 242016 | 1205 | 50361860 |
Hepatocellular injury | 47.42 | 13.85 | 33 | 242026 | 25914 | 50337151 |
Therapy non-responder | 47.33 | 13.85 | 411 | 241648 | 50611 | 50312454 |
Device related infection | 47.17 | 13.85 | 20 | 242039 | 20715 | 50342350 |
Hallucination, visual | 46.60 | 13.85 | 11 | 242048 | 16571 | 50346494 |
Ovarian neoplasm | 46.51 | 13.85 | 36 | 242023 | 816 | 50362249 |
Liver injury | 46.35 | 13.85 | 238 | 241821 | 24568 | 50338497 |
Anti-cyclic citrullinated peptide antibody | 46.16 | 13.85 | 47 | 242012 | 1545 | 50361520 |
Neoplasm malignant | 46.04 | 13.85 | 230 | 241829 | 23485 | 50339580 |
Throat tightness | 46.02 | 13.85 | 21 | 242038 | 20826 | 50342239 |
Blood glucose decreased | 45.73 | 13.85 | 15 | 242044 | 18196 | 50344869 |
Blindness | 45.57 | 13.85 | 13 | 242046 | 17256 | 50345809 |
Sleep apnoea syndrome | 45.44 | 13.85 | 29 | 242030 | 23839 | 50339226 |
Abdominal pain upper | 45.37 | 13.85 | 515 | 241544 | 158794 | 50204271 |
Suicidal ideation | 45.33 | 13.85 | 126 | 241933 | 55259 | 50307806 |
Hyperlipidaemia | 44.64 | 13.85 | 14 | 242045 | 17476 | 50345589 |
Flatulence | 44.56 | 13.85 | 45 | 242014 | 29413 | 50333652 |
Cardiogenic shock | 44.53 | 13.85 | 10 | 242049 | 15589 | 50347476 |
Alanine aminotransferase abnormal | 44.47 | 13.85 | 75 | 241984 | 4081 | 50358984 |
Haemorrhage intracranial | 44.42 | 13.85 | 4 | 242055 | 12370 | 50350695 |
Tachypnoea | 44.41 | 13.85 | 8 | 242051 | 14569 | 50348496 |
Product substitution issue | 44.41 | 13.85 | 7 | 242052 | 14050 | 50349015 |
Hepatitis | 44.41 | 13.85 | 280 | 241779 | 31173 | 50331892 |
Circulatory collapse | 44.38 | 13.85 | 20 | 242039 | 19980 | 50343085 |
Back injury | 44.29 | 13.85 | 102 | 241957 | 6983 | 50356082 |
Retching | 43.98 | 13.85 | 5 | 242054 | 12857 | 50350208 |
Live birth | 43.83 | 13.85 | 175 | 241884 | 16233 | 50346832 |
Feeling hot | 43.81 | 13.85 | 75 | 241984 | 39127 | 50323938 |
Pericardial effusion | 43.60 | 13.85 | 35 | 242024 | 25554 | 50337511 |
Ataxia | 43.25 | 13.85 | 7 | 242052 | 13779 | 50349286 |
Spinal stenosis | 43.25 | 13.85 | 153 | 241906 | 13397 | 50349668 |
Progressive multifocal leukoencephalopathy | 43.09 | 13.85 | 3 | 242056 | 11454 | 50351611 |
Cyanosis | 42.81 | 13.85 | 10 | 242049 | 15174 | 50347891 |
Colitis | 42.80 | 13.85 | 74 | 241985 | 38455 | 50324610 |
Surgery | 42.51 | 13.85 | 49 | 242010 | 30156 | 50332909 |
Drug dependence | 41.94 | 13.85 | 21 | 242038 | 19738 | 50343327 |
Therapy interrupted | 41.90 | 13.85 | 22 | 242037 | 20130 | 50342935 |
Restless legs syndrome | 41.89 | 13.85 | 12 | 242047 | 15885 | 50347180 |
Extrapyramidal disorder | 41.73 | 13.85 | 4 | 242055 | 11766 | 50351299 |
Cholestasis | 41.73 | 13.85 | 36 | 242023 | 25365 | 50337700 |
Infusion site pain | 41.72 | 13.85 | 5 | 242054 | 12341 | 50350724 |
Bacteraemia | 41.71 | 13.85 | 9 | 242050 | 14424 | 50348641 |
Hemiparesis | 41.52 | 13.85 | 22 | 242037 | 20026 | 50343039 |
Hypersomnia | 41.40 | 13.85 | 11 | 242048 | 15303 | 50347762 |
Deafness neurosensory | 41.40 | 13.85 | 76 | 241983 | 4425 | 50358640 |
Mitral valve incompetence | 41.13 | 13.85 | 16 | 242043 | 17455 | 50345610 |
Myelodysplastic syndrome | 40.66 | 13.85 | 11 | 242048 | 15121 | 50347944 |
Haemoptysis | 39.91 | 13.85 | 38 | 242021 | 25535 | 50337530 |
Dystonia | 39.88 | 13.85 | 5 | 242054 | 11921 | 50351144 |
Thyroid neoplasm | 39.82 | 13.85 | 65 | 241994 | 3442 | 50359623 |
Synovial fluid analysis | 39.76 | 13.85 | 44 | 242015 | 1594 | 50361471 |
Gamma-glutamyltransferase increased | 39.63 | 13.85 | 50 | 242009 | 29573 | 50333492 |
Pain in extremity | 39.45 | 13.85 | 1638 | 240421 | 271227 | 50091838 |
Osteonecrosis | 39.37 | 13.85 | 30 | 242029 | 22487 | 50340578 |
Off label use | 39.24 | 13.85 | 2702 | 239357 | 471724 | 49891341 |
Tinnitus | 39.20 | 13.85 | 46 | 242013 | 28086 | 50334979 |
Product prescribing error | 39.18 | 13.85 | 26 | 242033 | 20935 | 50342130 |
Blood magnesium decreased | 39.02 | 13.85 | 4 | 242055 | 11156 | 50351909 |
Staphylococcal infection | 39.02 | 13.85 | 69 | 241990 | 35547 | 50327518 |
Haematemesis | 39.00 | 13.85 | 45 | 242014 | 27680 | 50335385 |
Bone density decreased | 38.80 | 13.85 | 129 | 241930 | 10946 | 50352119 |
Labelled drug-drug interaction medication error | 38.67 | 13.85 | 3 | 242056 | 10474 | 50352591 |
Coordination abnormal | 38.17 | 13.85 | 5 | 242054 | 11529 | 50351536 |
Rash erythematous | 37.75 | 13.85 | 68 | 241991 | 34784 | 50328281 |
Acute hepatic failure | 37.50 | 13.85 | 14 | 242045 | 15663 | 50347402 |
Cerebral infarction | 37.50 | 13.85 | 29 | 242030 | 21575 | 50341490 |
Full blood count abnormal | 37.39 | 13.85 | 34 | 242025 | 23354 | 50339711 |
Small intestinal obstruction | 37.36 | 13.85 | 15 | 242044 | 16053 | 50347012 |
Heart rate increased | 37.05 | 13.85 | 217 | 241842 | 77033 | 50286032 |
Mean cell haemoglobin decreased | 36.94 | 13.85 | 61 | 241998 | 3262 | 50359803 |
Muscle spasticity | 36.87 | 13.85 | 18 | 242041 | 17166 | 50345899 |
Cytomegalovirus infection | 36.77 | 13.85 | 20 | 242039 | 17942 | 50345123 |
Cystitis | 36.75 | 13.85 | 101 | 241958 | 44463 | 50318602 |
Nodule | 36.68 | 13.85 | 170 | 241889 | 16833 | 50346232 |
Oropharyngeal pain | 36.55 | 13.85 | 220 | 241839 | 77581 | 50285484 |
Malaise | 36.28 | 13.85 | 1277 | 240782 | 334255 | 50028810 |
Tuberculin test positive | 36.11 | 13.85 | 59 | 242000 | 3127 | 50359938 |
Lip swelling | 36.05 | 13.85 | 39 | 242020 | 24697 | 50338368 |
Device difficult to use | 36.02 | 13.85 | 3 | 242056 | 9883 | 50353182 |
Liver function test abnormal | 35.96 | 13.85 | 347 | 241712 | 43992 | 50319073 |
No adverse event | 35.94 | 13.85 | 66 | 241993 | 33512 | 50329553 |
Nightmare | 35.82 | 13.85 | 16 | 242043 | 16070 | 50346995 |
Sinus disorder | 35.73 | 13.85 | 22 | 242037 | 18436 | 50344629 |
Respiratory depression | 35.72 | 13.85 | 7 | 242052 | 12003 | 50351062 |
Mania | 35.49 | 13.85 | 5 | 242054 | 10911 | 50352154 |
Angioedema | 35.27 | 13.85 | 80 | 241979 | 37596 | 50325469 |
Brain oedema | 35.17 | 13.85 | 8 | 242051 | 12362 | 50350703 |
Acute myeloid leukaemia | 35.16 | 13.85 | 14 | 242045 | 15060 | 50348005 |
Eye swelling | 35.02 | 13.85 | 27 | 242032 | 20117 | 50342948 |
Diabetic ketoacidosis | 35.02 | 13.85 | 21 | 242038 | 17851 | 50345214 |
Tenosynovitis stenosans | 34.97 | 13.85 | 48 | 242011 | 2176 | 50360889 |
Panic attack | 34.82 | 13.85 | 25 | 242034 | 19317 | 50343748 |
Metastases to central nervous system | 34.79 | 13.85 | 6 | 242053 | 11276 | 50351789 |
Peptic ulcer haemorrhage | 34.72 | 13.85 | 33 | 242026 | 996 | 50362069 |
Malnutrition | 34.67 | 13.85 | 10 | 242049 | 13179 | 50349886 |
Presyncope | 34.33 | 13.85 | 39 | 242020 | 24159 | 50338906 |
Hypovolaemia | 34.14 | 13.85 | 3 | 242056 | 9462 | 50353603 |
Joint injury | 33.95 | 13.85 | 199 | 241860 | 21590 | 50341475 |
Incontinence | 33.85 | 13.85 | 4 | 242055 | 9981 | 50353084 |
Device malfunction | 33.74 | 13.85 | 15 | 242044 | 15106 | 50347959 |
Metastases to liver | 33.63 | 13.85 | 28 | 242031 | 20076 | 50342989 |
Osteoporosis | 33.39 | 13.85 | 345 | 241714 | 44534 | 50318531 |
Joint dislocation | 33.32 | 13.85 | 132 | 241927 | 12201 | 50350864 |
Nervous system disorder | 33.31 | 13.85 | 18 | 242041 | 16205 | 50346860 |
Aspiration | 33.24 | 13.85 | 3 | 242056 | 9261 | 50353804 |
Abdominal pain lower | 33.18 | 13.85 | 33 | 242026 | 21723 | 50341342 |
Therapeutic product effect variable | 33.11 | 13.85 | 33 | 242026 | 1057 | 50362008 |
Tricuspid valve incompetence | 32.99 | 13.85 | 10 | 242049 | 12760 | 50350305 |
Drug reaction with eosinophilia and systemic symptoms | 32.94 | 13.85 | 241 | 241818 | 28183 | 50334882 |
Hepatic enzyme abnormal | 32.76 | 13.85 | 72 | 241987 | 4777 | 50358288 |
Caesarean section | 32.62 | 13.85 | 17 | 242042 | 15622 | 50347443 |
Hyperthyroidism | 32.44 | 13.85 | 9 | 242050 | 12166 | 50350899 |
Arteriosclerosis | 32.41 | 13.85 | 3 | 242056 | 9074 | 50353991 |
Femur fracture | 32.34 | 13.85 | 83 | 241976 | 37381 | 50325684 |
Body temperature increased | 32.31 | 13.85 | 63 | 241996 | 31278 | 50331787 |
Subdural haematoma | 31.93 | 13.85 | 11 | 242048 | 12936 | 50350129 |
Mental impairment | 31.91 | 13.85 | 9 | 242050 | 12035 | 50351030 |
Toxic epidermal necrolysis | 31.83 | 13.85 | 32 | 242027 | 20960 | 50342105 |
Acute generalised exanthematous pustulosis | 31.79 | 13.85 | 3 | 242056 | 8935 | 50354130 |
Central nervous system lesion | 31.68 | 13.85 | 4 | 242055 | 9485 | 50353580 |
Intestinal sepsis | 31.61 | 13.85 | 18 | 242041 | 238 | 50362827 |
Ventricular extrasystoles | 31.55 | 13.85 | 6 | 242053 | 10510 | 50352555 |
Anal incontinence | 31.55 | 13.85 | 8 | 242051 | 11482 | 50351583 |
Left ventricular dysfunction | 31.51 | 13.85 | 6 | 242053 | 10500 | 50352565 |
Premature labour | 31.49 | 13.85 | 8 | 242051 | 11468 | 50351597 |
Nasal congestion | 31.17 | 13.85 | 132 | 241927 | 50988 | 50312077 |
Dementia | 31.06 | 13.85 | 19 | 242040 | 15978 | 50347087 |
Contusion | 31.06 | 13.85 | 729 | 241330 | 111454 | 50251611 |
Blood triglycerides increased | 30.82 | 13.85 | 8 | 242051 | 11304 | 50351761 |
Swelling face | 30.74 | 13.85 | 138 | 241921 | 52457 | 50310608 |
Psoriasis | 30.63 | 13.85 | 482 | 241577 | 68518 | 50294547 |
Peritonitis | 30.62 | 13.85 | 18 | 242041 | 15468 | 50347597 |
Subarachnoid haemorrhage | 30.57 | 13.85 | 7 | 242052 | 10769 | 50352296 |
Dermatitis contact | 30.49 | 13.85 | 3 | 242056 | 8643 | 50354422 |
Renal disorder | 30.39 | 13.85 | 53 | 242006 | 27452 | 50335613 |
Scleritis | 30.33 | 13.85 | 55 | 242004 | 3172 | 50359893 |
Haematochezia | 30.26 | 13.85 | 94 | 241965 | 39788 | 50323277 |
Multiple sclerosis | 30.21 | 13.85 | 32 | 242027 | 20461 | 50342604 |
Lymphoedema | 30.08 | 13.85 | 4 | 242055 | 9118 | 50353947 |
Tuberculosis | 29.76 | 13.85 | 111 | 241948 | 9972 | 50353093 |
Supraventricular tachycardia | 29.68 | 13.85 | 12 | 242047 | 12789 | 50350276 |
Sudden death | 29.51 | 13.85 | 4 | 242055 | 8987 | 50354078 |
Bone cyst | 29.32 | 13.85 | 42 | 242017 | 1982 | 50361083 |
Sensory disturbance | 29.26 | 13.85 | 10 | 242049 | 11819 | 50351246 |
Myelosuppression | 29.24 | 13.85 | 14 | 242045 | 13503 | 50349562 |
Shock haemorrhagic | 29.15 | 13.85 | 3 | 242056 | 8341 | 50354724 |
Kidney infection | 29.09 | 13.85 | 28 | 242031 | 18718 | 50344347 |
Acute coronary syndrome | 28.87 | 13.85 | 5 | 242054 | 9369 | 50353696 |
Breast cancer | 28.79 | 13.85 | 323 | 241736 | 42567 | 50320498 |
Chromaturia | 28.79 | 13.85 | 17 | 242042 | 14573 | 50348492 |
Lyme disease | 28.70 | 13.85 | 47 | 242012 | 2496 | 50360569 |
Immobile | 28.60 | 13.85 | 70 | 241989 | 4984 | 50358081 |
Injection site haemorrhage | 28.58 | 13.85 | 36 | 242023 | 21310 | 50341755 |
Atrial flutter | 28.52 | 13.85 | 4 | 242055 | 8759 | 50354306 |
Tongue disorder | 28.50 | 13.85 | 103 | 241956 | 9113 | 50353952 |
Lymphopenia | 28.37 | 13.85 | 20 | 242039 | 15601 | 50347464 |
Infusion site erythema | 28.37 | 13.85 | 4 | 242055 | 8723 | 50354342 |
Acidosis | 28.31 | 13.85 | 7 | 242052 | 10220 | 50352845 |
Leukocytosis | 28.28 | 13.85 | 40 | 242019 | 22539 | 50340526 |
Mass excision | 28.17 | 13.85 | 17 | 242042 | 252 | 50362813 |
Skin burning sensation | 28.14 | 13.85 | 7 | 242052 | 10178 | 50352887 |
Renal impairment | 28.14 | 13.85 | 229 | 241830 | 75432 | 50287633 |
Pustular psoriasis | 27.91 | 13.85 | 60 | 241999 | 3921 | 50359144 |
Acute respiratory distress syndrome | 27.82 | 13.85 | 36 | 242023 | 21063 | 50342002 |
Hepatotoxicity | 27.73 | 13.85 | 224 | 241835 | 27002 | 50336063 |
Nasopharyngitis | 27.59 | 13.85 | 1157 | 240902 | 191770 | 50171295 |
Pulmonary toxicity | 27.29 | 13.85 | 73 | 241986 | 5489 | 50357576 |
Bronchitis | 27.23 | 13.85 | 343 | 241716 | 103816 | 50259249 |
Thrombosis | 27.22 | 13.85 | 156 | 241903 | 55677 | 50307388 |
Feeling cold | 27.15 | 13.85 | 32 | 242027 | 19499 | 50343566 |
Stress cardiomyopathy | 27.13 | 13.85 | 3 | 242056 | 7884 | 50355181 |
Erythema | 27.10 | 13.85 | 515 | 241544 | 145899 | 50217166 |
Hypophosphataemia | 27.01 | 13.85 | 4 | 242055 | 8410 | 50354655 |
Mucosal inflammation | 26.79 | 13.85 | 100 | 241959 | 40042 | 50323023 |
Cartilage atrophy | 26.66 | 13.85 | 14 | 242045 | 156 | 50362909 |
Hallucination, auditory | 26.65 | 13.85 | 9 | 242050 | 10719 | 50352346 |
Eosinophilia | 26.53 | 13.85 | 30 | 242029 | 18622 | 50344443 |
Monocyte count increased | 26.48 | 13.85 | 72 | 241987 | 5467 | 50357598 |
Inappropriate antidiuretic hormone secretion | 26.38 | 13.85 | 15 | 242044 | 13128 | 50349937 |
Limb injury | 26.24 | 13.85 | 35 | 242024 | 20215 | 50342850 |
Viral infection | 26.22 | 13.85 | 66 | 241993 | 29920 | 50333145 |
Gout | 26.19 | 13.85 | 11 | 242048 | 11459 | 50351606 |
Drug tolerance | 26.15 | 13.85 | 67 | 241992 | 4909 | 50358156 |
Metastases to lung | 26.09 | 13.85 | 10 | 242049 | 11010 | 50352055 |
Hepatic encephalopathy | 25.90 | 13.85 | 7 | 242052 | 9629 | 50353436 |
Anger | 25.67 | 13.85 | 11 | 242048 | 11322 | 50351743 |
Heart rate irregular | 25.56 | 13.85 | 33 | 242026 | 19327 | 50343738 |
Lung disorder | 25.52 | 13.85 | 327 | 241732 | 44472 | 50318593 |
Uveitis | 25.43 | 13.85 | 100 | 241959 | 9210 | 50353855 |
Obesity | 25.36 | 13.85 | 152 | 241907 | 16623 | 50346442 |
Lipase increased | 25.35 | 13.85 | 5 | 242054 | 8536 | 50354529 |
Haemodynamic instability | 25.34 | 13.85 | 4 | 242055 | 8020 | 50355045 |
Paranoia | 25.16 | 13.85 | 9 | 242050 | 10339 | 50352726 |
Amenorrhoea | 25.12 | 13.85 | 5 | 242054 | 8479 | 50354586 |
Dialysis | 25.10 | 13.85 | 7 | 242052 | 9431 | 50353634 |
Ageusia | 25.05 | 13.85 | 12 | 242047 | 11571 | 50351494 |
Dental caries | 25.00 | 13.85 | 8 | 242051 | 9859 | 50353206 |
Spinal meningioma benign | 24.96 | 13.85 | 12 | 242047 | 109 | 50362956 |
Cholecystitis | 24.87 | 13.85 | 18 | 242041 | 13853 | 50349212 |
Gastritis | 24.84 | 13.85 | 78 | 241981 | 32905 | 50330160 |
Epigastric discomfort | 24.83 | 13.85 | 73 | 241986 | 5797 | 50357268 |
Amnesia | 24.62 | 13.85 | 111 | 241948 | 42149 | 50320916 |
Prothrombin time prolonged | 24.56 | 13.85 | 6 | 242053 | 8832 | 50354233 |
Diverticulum | 24.53 | 13.85 | 10 | 242049 | 10604 | 50352461 |
Hiatus hernia | 24.50 | 13.85 | 31 | 242028 | 18313 | 50344752 |
Product storage error | 24.46 | 13.85 | 14 | 242045 | 12210 | 50350855 |
Ecchymosis | 24.46 | 13.85 | 9 | 242050 | 10160 | 50352905 |
Acute pulmonary oedema | 24.41 | 13.85 | 3 | 242056 | 7264 | 50355801 |
Lupus-like syndrome | 24.37 | 13.85 | 100 | 241959 | 9391 | 50353674 |
Thrombotic microangiopathy | 24.37 | 13.85 | 6 | 242053 | 8785 | 50354280 |
Respiratory rate increased | 24.31 | 13.85 | 12 | 242047 | 11373 | 50351692 |
Escherichia infection | 24.18 | 13.85 | 11 | 242048 | 10930 | 50352135 |
Rib fracture | 24.12 | 13.85 | 34 | 242025 | 19187 | 50343878 |
Klebsiella infection | 24.09 | 13.85 | 3 | 242056 | 7191 | 50355874 |
Dysphonia | 23.97 | 13.85 | 100 | 241959 | 38792 | 50324273 |
Faeces discoloured | 23.97 | 13.85 | 25 | 242034 | 16099 | 50346966 |
Neck mass | 23.96 | 13.85 | 51 | 242008 | 3310 | 50359755 |
Device breakage | 23.73 | 13.85 | 8 | 242051 | 9539 | 50353526 |
Arteriosclerosis coronary artery | 23.68 | 13.85 | 4 | 242055 | 7632 | 50355433 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 23.66 | 13.85 | 41 | 242018 | 2281 | 50360784 |
Cardiac murmur | 23.59 | 13.85 | 11 | 242048 | 10773 | 50352292 |
Breast cancer metastatic | 23.57 | 13.85 | 10 | 242049 | 10354 | 50352711 |
Mycobacterium marinum infection | 23.52 | 13.85 | 14 | 242045 | 202 | 50362863 |
Bedridden | 23.51 | 13.85 | 98 | 241961 | 9269 | 50353796 |
Gait disturbance | 23.38 | 13.85 | 908 | 241151 | 149097 | 50213968 |
Rash macular | 23.31 | 13.85 | 35 | 242024 | 19242 | 50343823 |
Sinusitis | 23.29 | 13.85 | 1018 | 241041 | 169540 | 50193525 |
Hypoalbuminaemia | 23.26 | 13.85 | 9 | 242050 | 9851 | 50353214 |
Decubitus ulcer | 23.23 | 13.85 | 8 | 242051 | 9410 | 50353655 |
Productive cough | 23.20 | 13.85 | 152 | 241907 | 52542 | 50310523 |
Ankle arthroplasty | 23.18 | 13.85 | 28 | 242031 | 1116 | 50361949 |
Oesophagitis | 23.18 | 13.85 | 18 | 242041 | 13365 | 50349700 |
Apnoea | 23.10 | 13.85 | 3 | 242056 | 6963 | 50356102 |
Paraesthesia oral | 23.06 | 13.85 | 15 | 242044 | 12206 | 50350859 |
Iron deficiency anaemia | 22.95 | 13.85 | 28 | 242031 | 16806 | 50346259 |
Lower limb fracture | 22.77 | 13.85 | 131 | 241928 | 14115 | 50348950 |
Gingival bleeding | 22.72 | 13.85 | 13 | 242046 | 11340 | 50351725 |
Incorrect product administration duration | 22.66 | 13.85 | 8 | 242051 | 9267 | 50353798 |
Hemiplegia | 22.60 | 13.85 | 4 | 242055 | 7377 | 50355688 |
Synovial cyst | 22.54 | 13.85 | 88 | 241971 | 8078 | 50354987 |
Blood creatinine increased | 22.53 | 13.85 | 244 | 241815 | 75916 | 50287149 |
Underdose | 22.47 | 13.85 | 39 | 242020 | 20239 | 50342826 |
Sleep disorder | 22.42 | 13.85 | 392 | 241667 | 56891 | 50306174 |
Diabetes mellitus inadequate control | 22.37 | 13.85 | 18 | 242041 | 13127 | 50349938 |
Migraine | 22.34 | 13.85 | 241 | 241818 | 75039 | 50288026 |
Oedema | 22.34 | 13.85 | 221 | 241838 | 69960 | 50293105 |
Allergy to metals | 22.22 | 13.85 | 19 | 242040 | 498 | 50362567 |
Gastroenteritis | 22.14 | 13.85 | 49 | 242010 | 23232 | 50339833 |
Juvenile idiopathic arthritis | 22.06 | 13.85 | 45 | 242014 | 2834 | 50360231 |
Sensory loss | 22.01 | 13.85 | 5 | 242054 | 7733 | 50355332 |
Lung infiltration | 21.97 | 13.85 | 19 | 242040 | 13374 | 50349691 |
Bursitis | 21.94 | 13.85 | 181 | 241878 | 21954 | 50341111 |
Hypoaesthesia oral | 21.88 | 13.85 | 12 | 242047 | 10716 | 50352349 |
Disseminated intravascular coagulation | 21.82 | 13.85 | 30 | 242029 | 17105 | 50345960 |
Renal injury | 21.79 | 13.85 | 7 | 242052 | 8604 | 50354461 |
Troponin increased | 21.63 | 13.85 | 6 | 242053 | 8112 | 50354953 |
Sacroiliitis | 21.59 | 13.85 | 42 | 242017 | 2555 | 50360510 |
Cold sweat | 21.57 | 13.85 | 12 | 242047 | 10632 | 50352433 |
Polyuria | 21.50 | 13.85 | 4 | 242055 | 7117 | 50355948 |
Precancerous cells present | 21.44 | 13.85 | 28 | 242031 | 1209 | 50361856 |
Faecaloma | 21.44 | 13.85 | 4 | 242055 | 7104 | 50355961 |
Effusion | 21.39 | 13.85 | 32 | 242027 | 1571 | 50361494 |
Salt craving | 21.37 | 13.85 | 10 | 242049 | 85 | 50362980 |
Pancreatitis | 21.35 | 13.85 | 118 | 241941 | 42496 | 50320569 |
Blood urine present | 21.31 | 13.85 | 18 | 242041 | 12815 | 50350250 |
Injection site swelling | 21.30 | 13.85 | 115 | 241944 | 41658 | 50321407 |
Delirium | 21.25 | 13.85 | 102 | 241957 | 38090 | 50324975 |
Ear pain | 21.22 | 13.85 | 67 | 241992 | 28216 | 50334849 |
Thyroid disorder | 21.21 | 13.85 | 118 | 241941 | 12559 | 50350506 |
Incorrect dosage administered | 21.15 | 13.85 | 33 | 242026 | 1681 | 50361384 |
Neutrophil count increased | 21.11 | 13.85 | 22 | 242037 | 14173 | 50348892 |
Metastases to lymph nodes | 21.09 | 13.85 | 4 | 242055 | 7020 | 50356045 |
Coronary artery occlusion | 21.04 | 13.85 | 5 | 242054 | 7498 | 50355567 |
COVID-19 pneumonia | 20.93 | 13.85 | 7 | 242052 | 8388 | 50354677 |
Adrenal insufficiency | 20.86 | 13.85 | 128 | 241931 | 14115 | 50348950 |
Injection site pruritus | 20.74 | 13.85 | 111 | 241948 | 40300 | 50322765 |
Post procedural complication | 20.72 | 13.85 | 25 | 242034 | 15079 | 50347986 |
Activated partial thromboplastin time prolonged | 20.66 | 13.85 | 3 | 242056 | 6399 | 50356666 |
Stevens-Johnson syndrome | 20.51 | 13.85 | 46 | 242013 | 21706 | 50341359 |
Lower gastrointestinal haemorrhage | 20.48 | 13.85 | 4 | 242055 | 6875 | 50356190 |
Deafness | 20.46 | 13.85 | 27 | 242032 | 15664 | 50347401 |
Sinus congestion | 20.39 | 13.85 | 22 | 242037 | 13949 | 50349116 |
Anovulatory cycle | 20.38 | 13.85 | 11 | 242048 | 130 | 50362935 |
Skin discolouration | 20.33 | 13.85 | 84 | 241975 | 32673 | 50330392 |
Blood albumin decreased | 20.27 | 13.85 | 20 | 242039 | 13216 | 50349849 |
Hypothyroidism | 20.26 | 13.85 | 89 | 241970 | 34036 | 50329029 |
Tooth extraction | 20.25 | 13.85 | 9 | 242050 | 9066 | 50353999 |
Colitis ischaemic | 20.24 | 13.85 | 10 | 242049 | 9473 | 50353592 |
Gastric ulcer | 20.13 | 13.85 | 45 | 242014 | 21260 | 50341805 |
Polyglandular disorder | 20.13 | 13.85 | 7 | 242052 | 24 | 50363041 |
Abdominal tenderness | 20.12 | 13.85 | 5 | 242054 | 7275 | 50355790 |
Inappropriate schedule of product administration | 20.12 | 13.85 | 233 | 241826 | 71598 | 50291467 |
Foetal death | 20.08 | 13.85 | 7 | 242052 | 8173 | 50354892 |
Post procedural haemorrhage | 20.08 | 13.85 | 5 | 242054 | 7265 | 50355800 |
Rash maculo-papular | 20.06 | 13.85 | 63 | 241996 | 26578 | 50336487 |
Skin irritation | 20.05 | 13.85 | 6 | 242053 | 7721 | 50355344 |
Septic shock | 19.93 | 13.85 | 176 | 241883 | 56999 | 50306066 |
Bundle branch block left | 19.91 | 13.85 | 3 | 242056 | 6227 | 50356838 |
Stress at work | 19.86 | 13.85 | 25 | 242034 | 1040 | 50362025 |
Neutropenic sepsis | 19.85 | 13.85 | 23 | 242036 | 14124 | 50348941 |
Nocturia | 19.85 | 13.85 | 4 | 242055 | 6726 | 50356339 |
Joint space narrowing | 19.80 | 13.85 | 13 | 242046 | 225 | 50362840 |
Rhinitis allergic | 19.79 | 13.85 | 5 | 242054 | 7195 | 50355870 |
Abortion induced | 19.73 | 13.85 | 10 | 242049 | 9334 | 50353731 |
Infusion site swelling | 19.70 | 13.85 | 5 | 242054 | 7171 | 50355894 |
Gallbladder disorder | 19.67 | 13.85 | 31 | 242028 | 16711 | 50346354 |
Myocardial ischaemia | 19.64 | 13.85 | 16 | 242043 | 11597 | 50351468 |
Gastrointestinal toxicity | 19.63 | 13.85 | 58 | 242001 | 4619 | 50358446 |
Psychomotor hyperactivity | 19.57 | 13.85 | 10 | 242049 | 9291 | 50353774 |
Eructation | 19.47 | 13.85 | 5 | 242054 | 7116 | 50355949 |
Maternal exposure timing unspecified | 19.29 | 13.85 | 49 | 242010 | 3571 | 50359494 |
Adjustment disorder with depressed mood | 19.26 | 13.85 | 42 | 242017 | 2772 | 50360293 |
Cardiomegaly | 19.23 | 13.85 | 29 | 242030 | 15916 | 50347149 |
Neuralgia | 19.21 | 13.85 | 48 | 242011 | 21815 | 50341250 |
Spondyloarthropathy | 19.20 | 13.85 | 21 | 242038 | 751 | 50362314 |
Demyelination | 19.19 | 13.85 | 68 | 241991 | 5958 | 50357107 |
Ileus | 19.12 | 13.85 | 21 | 242038 | 13208 | 50349857 |
Tendonitis | 18.99 | 13.85 | 141 | 241918 | 16564 | 50346501 |
Injection site warmth | 18.97 | 13.85 | 23 | 242036 | 13843 | 50349222 |
Peripheral coldness | 18.89 | 13.85 | 13 | 242046 | 10270 | 50352795 |
Pulmonary haemorrhage | 18.86 | 13.85 | 4 | 242055 | 6488 | 50356577 |
Exposure during pregnancy | 18.77 | 13.85 | 438 | 241621 | 120577 | 50242488 |
Respiratory disorder | 18.72 | 13.85 | 81 | 241978 | 31106 | 50331959 |
Respiratory tract infection | 18.71 | 13.85 | 84 | 241975 | 31933 | 50331132 |
Anaphylactic shock | 18.70 | 13.85 | 43 | 242016 | 20112 | 50342953 |
Weber tuning fork test abnormal | 18.70 | 13.85 | 9 | 242050 | 82 | 50362983 |
Erythema multiforme | 18.64 | 13.85 | 10 | 242049 | 9040 | 50354025 |
Medication error | 18.62 | 13.85 | 99 | 241960 | 36005 | 50327060 |
Pseudomonas infection | 18.59 | 13.85 | 11 | 242048 | 9419 | 50353646 |
Glomerular filtration rate decreased | 18.55 | 13.85 | 17 | 242042 | 11635 | 50351430 |
Eye haemorrhage | 18.49 | 13.85 | 6 | 242053 | 7329 | 50355736 |
Renal tubular necrosis | 18.49 | 13.85 | 13 | 242046 | 10155 | 50352910 |
Skin laceration | 18.46 | 13.85 | 39 | 242020 | 18803 | 50344262 |
Urticarial vasculitis | 18.46 | 13.85 | 18 | 242041 | 561 | 50362504 |
Tooth disorder | 18.45 | 13.85 | 57 | 242002 | 24171 | 50338894 |
Wound infection | 18.31 | 13.85 | 110 | 241949 | 12038 | 50351027 |
Blood calcium increased | 18.28 | 13.85 | 7 | 242052 | 7712 | 50355353 |
Haemorrhoids | 18.20 | 13.85 | 40 | 242019 | 19013 | 50344052 |
Cardiomyopathy | 18.18 | 13.85 | 29 | 242030 | 15557 | 50347508 |
Rheumatic disorder | 18.07 | 13.85 | 29 | 242030 | 1514 | 50361551 |
Eyelid exfoliation | 17.98 | 13.85 | 10 | 242049 | 126 | 50362939 |
Pre-eclampsia | 17.91 | 13.85 | 8 | 242051 | 8036 | 50355029 |
Nephropathy toxic | 17.86 | 13.85 | 8 | 242051 | 8021 | 50355044 |
Electrocardiogram abnormal | 17.84 | 13.85 | 7 | 242052 | 7598 | 50355467 |
Bronchopulmonary aspergillosis | 17.79 | 13.85 | 7 | 242052 | 7585 | 50355480 |
Unevaluable event | 17.78 | 13.85 | 138 | 241921 | 45928 | 50317137 |
Adenoiditis | 17.74 | 13.85 | 7 | 242052 | 37 | 50363028 |
Oral lichen planus | 17.67 | 13.85 | 17 | 242042 | 521 | 50362544 |
Atrioventricular block first degree | 17.65 | 13.85 | 4 | 242055 | 6197 | 50356868 |
Hepatic cirrhosis | 17.57 | 13.85 | 144 | 241915 | 17433 | 50345632 |
Elbow deformity | 17.55 | 13.85 | 27 | 242032 | 1359 | 50361706 |
Generalised oedema | 17.52 | 13.85 | 24 | 242035 | 13707 | 50349358 |
Injection site mass | 17.52 | 13.85 | 30 | 242029 | 15650 | 50347415 |
Clear cell renal cell carcinoma | 17.48 | 13.85 | 25 | 242034 | 1178 | 50361887 |
Taste disorder | 17.44 | 13.85 | 9 | 242050 | 8315 | 50354750 |
C-reactive protein | 17.43 | 13.85 | 21 | 242038 | 835 | 50362230 |
Neck pain | 17.40 | 13.85 | 376 | 241683 | 56691 | 50306374 |
Osteopenia | 17.32 | 13.85 | 140 | 241919 | 16878 | 50346187 |
Rash papular | 17.15 | 13.85 | 21 | 242038 | 12583 | 50350482 |
Blood lactate dehydrogenase increased | 17.14 | 13.85 | 43 | 242016 | 19519 | 50343546 |
Colitis microscopic | 16.98 | 13.85 | 69 | 241990 | 6451 | 50356614 |
Device failure | 16.91 | 13.85 | 3 | 242056 | 5525 | 50357540 |
Hyperaesthesia | 16.88 | 13.85 | 9 | 242050 | 8164 | 50354901 |
C-reactive protein decreased | 16.84 | 13.85 | 20 | 242039 | 783 | 50362282 |
Enterococcal infection | 16.77 | 13.85 | 6 | 242053 | 6892 | 50356173 |
Aortic valve incompetence | 16.69 | 13.85 | 3 | 242056 | 5473 | 50357592 |
Tooth fracture | 16.69 | 13.85 | 13 | 242046 | 9638 | 50353427 |
Smear cervix abnormal | 16.63 | 13.85 | 39 | 242020 | 2702 | 50360363 |
Gingivitis | 16.61 | 13.85 | 7 | 242052 | 7277 | 50355788 |
Rales | 16.56 | 13.85 | 14 | 242045 | 9964 | 50353101 |
Aphonia | 16.55 | 13.85 | 10 | 242049 | 8468 | 50354597 |
Hereditary angioedema | 16.55 | 13.85 | 3 | 242056 | 5439 | 50357626 |
Cerebral ischaemia | 16.44 | 13.85 | 4 | 242055 | 5904 | 50357161 |
HLA marker study positive | 16.38 | 13.85 | 11 | 242048 | 198 | 50362867 |
Multiple allergies | 16.37 | 13.85 | 82 | 241977 | 8381 | 50354684 |
Tender joint count increased | 16.36 | 13.85 | 7 | 242052 | 47 | 50363018 |
Aortic arteriosclerosis | 16.30 | 13.85 | 3 | 242056 | 5379 | 50357686 |
Ureterocele | 16.29 | 13.85 | 5 | 242054 | 10 | 50363055 |
Retinal toxicity | 16.26 | 13.85 | 24 | 242035 | 1164 | 50361901 |
Dermatitis bullous | 16.19 | 13.85 | 7 | 242052 | 7166 | 50355899 |
Parotid gland enlargement | 16.16 | 13.85 | 19 | 242040 | 736 | 50362329 |
Increased appetite | 16.13 | 13.85 | 10 | 242049 | 8351 | 50354714 |
Prescribed underdose | 16.12 | 13.85 | 131 | 241928 | 15818 | 50347247 |
Fungal infection | 16.11 | 13.85 | 81 | 241978 | 29884 | 50333181 |
Hypersensitivity vasculitis | 16.10 | 13.85 | 49 | 242010 | 3966 | 50359099 |
Hepatic function abnormal | 16.10 | 13.85 | 91 | 241968 | 32590 | 50330475 |
Antinuclear antibody positive | 16.04 | 13.85 | 66 | 241993 | 6206 | 50356859 |
Vitreous floaters | 16.01 | 13.85 | 3 | 242056 | 5311 | 50357754 |
Muscle fatigue | 15.99 | 13.85 | 34 | 242025 | 2205 | 50360860 |
Pelvic pain | 15.99 | 13.85 | 18 | 242041 | 11195 | 50351870 |
Myositis | 15.95 | 13.85 | 9 | 242050 | 7911 | 50355154 |
Wound infection fungal | 15.87 | 13.85 | 9 | 242050 | 118 | 50362947 |
Axial spondyloarthritis | 15.87 | 13.85 | 11 | 242048 | 209 | 50362856 |
Eye pain | 15.82 | 13.85 | 76 | 241983 | 28373 | 50334692 |
Micturition urgency | 15.79 | 13.85 | 10 | 242049 | 8254 | 50354811 |
Immune thrombocytopenia | 15.78 | 13.85 | 12 | 242047 | 9005 | 50354060 |
Dysstasia | 15.75 | 13.85 | 39 | 242020 | 17780 | 50345285 |
Pharyngitis | 15.71 | 13.85 | 38 | 242021 | 17465 | 50345600 |
Eyelid ptosis | 15.71 | 13.85 | 5 | 242054 | 6182 | 50356883 |
Vaginal discharge | 15.70 | 13.85 | 3 | 242056 | 5237 | 50357828 |
Shoulder arthroplasty | 15.67 | 13.85 | 44 | 242015 | 3404 | 50359661 |
Granulocytopenia | 15.66 | 13.85 | 3 | 242056 | 5228 | 50357837 |
Infusion site extravasation | 15.44 | 13.85 | 7 | 242052 | 6969 | 50356096 |
Tubulointerstitial nephritis | 15.31 | 13.85 | 31 | 242028 | 15180 | 50347885 |
Squamous cell carcinoma | 15.29 | 13.85 | 9 | 242050 | 7730 | 50355335 |
Hyperreflexia | 15.18 | 13.85 | 3 | 242056 | 5115 | 50357950 |
Pulmonary tuberculosis | 15.17 | 13.85 | 50 | 242009 | 4223 | 50358842 |
Aplastic anaemia | 15.16 | 13.85 | 9 | 242050 | 7694 | 50355371 |
Jaundice cholestatic | 15.16 | 13.85 | 3 | 242056 | 5108 | 50357957 |
Glycosylated haemoglobin increased | 15.15 | 13.85 | 17 | 242042 | 10589 | 50352476 |
Blood pressure systolic abnormal | 15.14 | 13.85 | 75 | 241984 | 7631 | 50355434 |
Eosinophil count increased | 15.14 | 13.85 | 12 | 242047 | 8818 | 50354247 |
Nystagmus | 15.02 | 13.85 | 4 | 242055 | 5557 | 50357508 |
Maternal drugs affecting foetus | 15.01 | 13.85 | 3 | 242056 | 5074 | 50357991 |
Ganglioneuroma | 14.94 | 13.85 | 9 | 242050 | 133 | 50362932 |
Injection site induration | 14.92 | 13.85 | 11 | 242048 | 8386 | 50354679 |
Diverticulitis | 14.80 | 13.85 | 232 | 241827 | 32950 | 50330115 |
Crepitations | 14.78 | 13.85 | 64 | 241995 | 6155 | 50356910 |
Cushingoid | 14.75 | 13.85 | 67 | 241992 | 6578 | 50356487 |
Seasonal allergy | 14.70 | 13.85 | 30 | 242029 | 14646 | 50348419 |
Mood altered | 14.67 | 13.85 | 24 | 242035 | 12749 | 50350316 |
Pneumothorax | 14.65 | 13.85 | 28 | 242031 | 14006 | 50349059 |
Herpes simplex | 14.62 | 13.85 | 8 | 242051 | 7154 | 50355911 |
Upper limb fracture | 14.61 | 13.85 | 34 | 242025 | 15839 | 50347226 |
Intestinal ischaemia | 14.61 | 13.85 | 7 | 242052 | 6750 | 50356315 |
Breast pain | 14.59 | 13.85 | 9 | 242050 | 7535 | 50355530 |
Pruritus | 14.57 | 13.85 | 1163 | 240896 | 282405 | 50080660 |
Rotator cuff repair | 14.57 | 13.85 | 28 | 242031 | 1688 | 50361377 |
Urine output decreased | 14.56 | 13.85 | 17 | 242042 | 10404 | 50352661 |
Osteosclerosis | 14.56 | 13.85 | 43 | 242016 | 3424 | 50359641 |
Rash pruritic | 14.51 | 13.85 | 315 | 241744 | 47531 | 50315534 |
Cyst | 14.50 | 13.85 | 104 | 241955 | 12083 | 50350982 |
Low birth weight baby | 14.50 | 13.85 | 5 | 242054 | 5876 | 50357189 |
Extrapulmonary tuberculosis | 14.44 | 13.85 | 12 | 242047 | 302 | 50362763 |
Musculoskeletal chest pain | 14.43 | 13.85 | 43 | 242016 | 18443 | 50344622 |
Cholecystitis acute | 14.42 | 13.85 | 8 | 242051 | 7098 | 50355967 |
Liver disorder | 14.30 | 13.85 | 254 | 241805 | 36968 | 50326097 |
Thirst | 14.22 | 13.85 | 18 | 242041 | 10632 | 50352433 |
Bursitis infective | 14.19 | 13.85 | 23 | 242036 | 1211 | 50361854 |
Inflammatory marker increased | 14.18 | 13.85 | 59 | 242000 | 5575 | 50357490 |
Staphylococcal bacteraemia | 14.18 | 13.85 | 3 | 242056 | 4874 | 50358191 |
Exercise tolerance decreased | 14.16 | 13.85 | 3 | 242056 | 4871 | 50358194 |
Erysipelas | 14.06 | 13.85 | 7 | 242052 | 6601 | 50356464 |
Viral upper respiratory tract infection | 14.02 | 13.85 | 8 | 242051 | 6988 | 50356077 |
Procedural complication | 13.95 | 13.85 | 3 | 242056 | 4820 | 50358245 |
Oral mucosal blistering | 13.91 | 13.85 | 3 | 242056 | 4809 | 50358256 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug ineffective | 1878.34 | 14.15 | 2536 | 43517 | 360634 | 29167840 |
Drug intolerance | 1269.78 | 14.15 | 841 | 45212 | 47538 | 29480936 |
Joint swelling | 1085.01 | 14.15 | 771 | 45282 | 48859 | 29479615 |
Synovitis | 752.06 | 14.15 | 358 | 45695 | 10532 | 29517942 |
Contraindicated product administered | 700.65 | 14.15 | 405 | 45648 | 17861 | 29510613 |
Apparent death | 595.56 | 14.15 | 219 | 45834 | 3285 | 29525189 |
Treatment failure | 526.65 | 14.15 | 446 | 45607 | 36493 | 29491981 |
C-reactive protein abnormal | 460.66 | 14.15 | 218 | 45835 | 6318 | 29522156 |
Arthropathy | 456.50 | 14.15 | 329 | 45724 | 21225 | 29507249 |
Pain | 449.26 | 14.15 | 887 | 45166 | 170545 | 29357929 |
Diverticulitis | 434.97 | 14.15 | 296 | 45757 | 17408 | 29511066 |
Musculoskeletal stiffness | 425.89 | 14.15 | 398 | 45655 | 37060 | 29491414 |
Therapeutic product effect decreased | 387.94 | 14.15 | 340 | 45713 | 29111 | 29499363 |
Psoriatic arthropathy | 383.31 | 14.15 | 255 | 45798 | 14436 | 29514038 |
Arthralgia | 375.73 | 14.15 | 731 | 45322 | 138886 | 29389588 |
Rheumatoid arthritis | 371.93 | 14.15 | 345 | 45708 | 31807 | 29496667 |
C-reactive protein increased | 320.00 | 14.15 | 369 | 45684 | 43894 | 29484580 |
Loss of personal independence in daily activities | 307.81 | 14.15 | 280 | 45773 | 25160 | 29503314 |
Drug hypersensitivity | 300.44 | 14.15 | 446 | 45607 | 67960 | 29460514 |
Hand deformity | 292.69 | 14.15 | 114 | 45939 | 2016 | 29526458 |
Red blood cell sedimentation rate increased | 292.68 | 14.15 | 168 | 45885 | 7293 | 29521181 |
Mobility decreased | 235.13 | 14.15 | 243 | 45810 | 25537 | 29502937 |
Death | 194.20 | 14.15 | 150 | 45903 | 341934 | 29186540 |
Arthritis | 193.26 | 14.15 | 216 | 45837 | 24803 | 29503671 |
Lymphoma | 185.37 | 14.15 | 140 | 45913 | 9688 | 29518786 |
Pulmonary thrombosis | 183.44 | 14.15 | 119 | 45934 | 6446 | 29522028 |
Enthesopathy | 181.68 | 14.15 | 97 | 45956 | 3646 | 29524828 |
Therapeutic product effect incomplete | 167.65 | 14.15 | 253 | 45800 | 39052 | 29489422 |
Toxicity to various agents | 166.53 | 14.15 | 34 | 46019 | 173627 | 29354847 |
Knee arthroplasty | 161.57 | 14.15 | 105 | 45948 | 5704 | 29522770 |
Impaired work ability | 157.00 | 14.15 | 102 | 45951 | 5538 | 29522936 |
Onychoclasis | 156.64 | 14.15 | 69 | 45984 | 1684 | 29526790 |
Acute kidney injury | 155.89 | 14.15 | 112 | 45941 | 265155 | 29263319 |
Tenosynovitis | 146.22 | 14.15 | 84 | 45969 | 3649 | 29524825 |
Ankylosing spondylitis | 142.63 | 14.15 | 86 | 45967 | 4090 | 29524384 |
Terminal state | 137.87 | 14.15 | 79 | 45974 | 3415 | 29525059 |
Inflammation | 135.53 | 14.15 | 172 | 45881 | 22556 | 29505918 |
Hypotension | 135.22 | 14.15 | 67 | 45986 | 194287 | 29334187 |
Drug tolerance decreased | 133.40 | 14.15 | 57 | 45996 | 1289 | 29527185 |
Drug interaction | 125.75 | 14.15 | 76 | 45977 | 197309 | 29331165 |
Deep vein thrombosis | 124.95 | 14.15 | 276 | 45777 | 57123 | 29471351 |
Gastrointestinal disorder | 118.44 | 14.15 | 182 | 45871 | 28524 | 29499950 |
Polyarthritis | 113.88 | 14.15 | 73 | 45980 | 3872 | 29524602 |
Red blood cell sedimentation rate abnormal | 112.66 | 14.15 | 60 | 45993 | 2243 | 29526231 |
Pulmonary fibrosis | 112.60 | 14.15 | 130 | 45923 | 15452 | 29513022 |
Febrile neutropenia | 111.68 | 14.15 | 20 | 46033 | 112220 | 29416254 |
Tooth loss | 111.07 | 14.15 | 70 | 45983 | 3604 | 29524870 |
Psoriasis | 110.69 | 14.15 | 188 | 45865 | 32039 | 29496435 |
Joint range of motion decreased | 109.21 | 14.15 | 84 | 45969 | 5970 | 29522504 |
Completed suicide | 106.98 | 14.15 | 9 | 46044 | 90237 | 29438237 |
Gastric disorder | 99.52 | 14.15 | 102 | 45951 | 10602 | 29517872 |
Confusional state | 98.47 | 14.15 | 38 | 46015 | 127839 | 29400635 |
Musculoskeletal pain | 98.24 | 14.15 | 168 | 45885 | 28785 | 29499689 |
Rheumatoid factor positive | 96.74 | 14.15 | 37 | 46016 | 621 | 29527853 |
Anaemia | 95.94 | 14.15 | 103 | 45950 | 200848 | 29327626 |
Joint stiffness | 94.91 | 14.15 | 94 | 45959 | 9379 | 29519095 |
Tongue disorder | 94.02 | 14.15 | 69 | 45984 | 4567 | 29523907 |
Herpes zoster | 93.69 | 14.15 | 168 | 45885 | 29884 | 29498590 |
Dehydration | 91.88 | 14.15 | 32 | 46021 | 114716 | 29413758 |
Sleep disorder due to general medical condition, insomnia type | 88.09 | 14.15 | 42 | 46011 | 1236 | 29527238 |
Alopecia | 87.28 | 14.15 | 127 | 45926 | 18957 | 29509517 |
Pulmonary embolism | 86.49 | 14.15 | 289 | 45764 | 76245 | 29452229 |
Malignant neoplasm progression | 85.81 | 14.15 | 8 | 46045 | 73851 | 29454623 |
Photosensitivity reaction | 85.67 | 14.15 | 88 | 45965 | 9170 | 29519304 |
Bone erosion | 84.47 | 14.15 | 53 | 46000 | 2707 | 29525767 |
Arthritis bacterial | 83.50 | 14.15 | 63 | 45990 | 4350 | 29524124 |
Joint arthroplasty | 81.76 | 14.15 | 33 | 46020 | 643 | 29527831 |
Tendonitis | 81.61 | 14.15 | 80 | 45973 | 7881 | 29520593 |
Alanine aminotransferase abnormal | 81.12 | 14.15 | 53 | 46000 | 2904 | 29525570 |
Interstitial lung disease | 77.15 | 14.15 | 231 | 45822 | 57487 | 29470987 |
Disability | 76.88 | 14.15 | 60 | 45993 | 4356 | 29524118 |
Hip arthroplasty | 76.36 | 14.15 | 56 | 45997 | 3702 | 29524772 |
Swelling | 75.98 | 14.15 | 169 | 45884 | 35114 | 29493360 |
Seronegative arthritis | 74.98 | 14.15 | 34 | 46019 | 890 | 29527584 |
Bladder transitional cell carcinoma | 74.67 | 14.15 | 47 | 46006 | 2414 | 29526060 |
Liver function test increased | 74.10 | 14.15 | 92 | 45961 | 11793 | 29516681 |
Condition aggravated | 73.36 | 14.15 | 433 | 45620 | 145862 | 29382612 |
Hyperkalaemia | 73.08 | 14.15 | 6 | 46047 | 61386 | 29467088 |
Cytology abnormal | 71.65 | 14.15 | 26 | 46027 | 374 | 29528100 |
Colitis ulcerative | 70.41 | 14.15 | 93 | 45960 | 12676 | 29515798 |
Bradycardia | 69.05 | 14.15 | 10 | 46043 | 65619 | 29462855 |
Osteoarthritis | 68.03 | 14.15 | 110 | 45943 | 17993 | 29510481 |
Uveitis | 65.18 | 14.15 | 62 | 45991 | 5885 | 29522589 |
Blood creatinine increased | 64.30 | 14.15 | 26 | 46027 | 85076 | 29443398 |
Atrial fibrillation | 63.98 | 14.15 | 43 | 46010 | 105603 | 29422871 |
Nodule | 63.20 | 14.15 | 57 | 45996 | 5055 | 29523419 |
Neoplasm malignant | 62.45 | 14.15 | 102 | 45951 | 16823 | 29511651 |
Intestinal sepsis | 61.93 | 14.15 | 24 | 46029 | 418 | 29528056 |
Rhabdomyolysis | 60.09 | 14.15 | 11 | 46042 | 60797 | 29467677 |
Immobile | 58.58 | 14.15 | 39 | 46014 | 2206 | 29526268 |
Foot deformity | 58.16 | 14.15 | 49 | 46004 | 3966 | 29524508 |
Thrombocytopenia | 56.92 | 14.15 | 76 | 45977 | 134747 | 29393727 |
Decreased appetite | 56.36 | 14.15 | 87 | 45966 | 145255 | 29383219 |
Cardiac arrest | 55.74 | 14.15 | 32 | 46021 | 85559 | 29442915 |
Hypokalaemia | 54.34 | 14.15 | 7 | 46046 | 50196 | 29478278 |
Intentional product use issue | 53.87 | 14.15 | 167 | 45886 | 42331 | 29486143 |
Seizure | 53.61 | 14.15 | 40 | 46013 | 93083 | 29435391 |
Axial spondyloarthritis | 53.49 | 14.15 | 19 | 46034 | 256 | 29528218 |
Overdose | 53.19 | 14.15 | 29 | 46024 | 79790 | 29448684 |
Somnolence | 52.01 | 14.15 | 42 | 46011 | 93913 | 29434561 |
Impaired quality of life | 50.90 | 14.15 | 38 | 46015 | 2581 | 29525893 |
Dyspnoea | 49.21 | 14.15 | 303 | 45750 | 326429 | 29202045 |
Infection | 49.12 | 14.15 | 243 | 45810 | 76508 | 29451966 |
Prerenal failure | 48.93 | 14.15 | 32 | 46021 | 1756 | 29526718 |
Limb discomfort | 48.66 | 14.15 | 67 | 45986 | 9501 | 29518973 |
Tuberculosis | 48.58 | 14.15 | 58 | 45995 | 7138 | 29521336 |
International normalised ratio increased | 48.48 | 14.15 | 6 | 46047 | 44366 | 29484108 |
Cardio-respiratory arrest | 48.20 | 14.15 | 10 | 46043 | 50591 | 29477883 |
Pain in extremity | 47.85 | 14.15 | 315 | 45738 | 110118 | 29418356 |
X-ray abnormal | 46.57 | 14.15 | 20 | 46033 | 458 | 29528016 |
Soft tissue swelling | 46.11 | 14.15 | 18 | 46035 | 320 | 29528154 |
Constipation | 45.52 | 14.15 | 67 | 45986 | 114093 | 29414381 |
Dizziness | 45.34 | 14.15 | 148 | 45905 | 189536 | 29338938 |
Musculoskeletal discomfort | 44.28 | 14.15 | 52 | 46001 | 6289 | 29522185 |
Lymphadenopathy | 44.15 | 14.15 | 111 | 45942 | 24938 | 29503536 |
Arthrodesis | 44.08 | 14.15 | 19 | 46034 | 439 | 29528035 |
Rheumatoid nodule | 43.97 | 14.15 | 32 | 46021 | 2090 | 29526384 |
Hypoxia | 43.84 | 14.15 | 10 | 46043 | 47369 | 29481105 |
Agitation | 43.33 | 14.15 | 13 | 46040 | 51291 | 29477183 |
Hepatic enzyme abnormal | 42.40 | 14.15 | 32 | 46021 | 2210 | 29526264 |
Hallucination | 42.25 | 14.15 | 9 | 46044 | 44703 | 29483771 |
Hospitalisation | 41.97 | 14.15 | 10 | 46043 | 45978 | 29482496 |
Electrocardiogram QT prolonged | 41.73 | 14.15 | 4 | 46049 | 36133 | 29492341 |
Pulmonary tuberculosis | 41.71 | 14.15 | 42 | 46011 | 4273 | 29524201 |
Asthenia | 41.69 | 14.15 | 183 | 45870 | 215067 | 29313407 |
Rheumatoid factor negative | 41.66 | 14.15 | 22 | 46031 | 808 | 29527666 |
Disease progression | 41.25 | 14.15 | 40 | 46013 | 81876 | 29446598 |
Off label use | 40.88 | 14.15 | 676 | 45377 | 300124 | 29228350 |
Pulmonary toxicity | 40.81 | 14.15 | 44 | 46009 | 4846 | 29523628 |
Hyponatraemia | 40.29 | 14.15 | 28 | 46025 | 67605 | 29460869 |
Drug reaction with eosinophilia and systemic symptoms | 40.21 | 14.15 | 115 | 45938 | 27877 | 29500597 |
Renal impairment | 39.49 | 14.15 | 41 | 46012 | 81292 | 29447182 |
Cerebrovascular accident | 39.38 | 14.15 | 37 | 46016 | 76874 | 29451600 |
Anti-cyclic citrullinated peptide antibody positive | 38.99 | 14.15 | 21 | 46032 | 803 | 29527671 |
Thrombosis | 37.93 | 14.15 | 150 | 45903 | 42895 | 29485579 |
Syncope | 37.32 | 14.15 | 43 | 46010 | 81328 | 29447146 |
Grip strength decreased | 37.27 | 14.15 | 30 | 46023 | 2277 | 29526197 |
Frequent bowel movements | 37.27 | 14.15 | 58 | 45995 | 9181 | 29519293 |
Blood creatine phosphokinase increased | 36.77 | 14.15 | 9 | 46044 | 40635 | 29487839 |
Peripheral swelling | 36.72 | 14.15 | 196 | 45857 | 63543 | 29464931 |
Dactylitis | 36.55 | 14.15 | 19 | 46034 | 675 | 29527799 |
Platelet count decreased | 36.53 | 14.15 | 67 | 45986 | 104605 | 29423869 |
Diarrhoea | 36.51 | 14.15 | 337 | 45716 | 332361 | 29196113 |
Suicide attempt | 36.33 | 14.15 | 5 | 46048 | 34105 | 29494369 |
Hypoglycaemia | 36.13 | 14.15 | 15 | 46038 | 48331 | 29480143 |
Blood pressure fluctuation | 35.94 | 14.15 | 89 | 45964 | 19805 | 29508669 |
Respiratory distress | 35.92 | 14.15 | 4 | 46049 | 32102 | 29496372 |
Limb deformity | 35.88 | 14.15 | 17 | 46036 | 493 | 29527981 |
Lactic acidosis | 35.86 | 14.15 | 3 | 46050 | 30244 | 29498230 |
Fine motor skill dysfunction | 35.85 | 14.15 | 25 | 46028 | 1526 | 29526948 |
Multiple organ dysfunction syndrome | 33.94 | 14.15 | 29 | 46024 | 63087 | 29465387 |
Ill-defined disorder | 33.49 | 14.15 | 63 | 45990 | 11615 | 29516859 |
Mental status changes | 33.06 | 14.15 | 7 | 46046 | 34920 | 29493554 |
Metabolic acidosis | 32.81 | 14.15 | 9 | 46044 | 37653 | 29490821 |
Blood glucose increased | 31.84 | 14.15 | 27 | 46026 | 58957 | 29469517 |
Muscular weakness | 31.59 | 14.15 | 30 | 46023 | 62022 | 29466452 |
Vomiting | 31.26 | 14.15 | 198 | 45855 | 212062 | 29316412 |
Septic shock | 30.97 | 14.15 | 31 | 46022 | 62529 | 29465945 |
Iritis | 30.78 | 14.15 | 21 | 46032 | 1237 | 29527237 |
Lymphoedema | 30.74 | 14.15 | 32 | 46021 | 3385 | 29525089 |
Abdominal pain | 30.68 | 14.15 | 108 | 45945 | 135249 | 29393225 |
Fall | 30.54 | 14.15 | 157 | 45896 | 177021 | 29351453 |
Xyphoid retraction | 30.08 | 14.15 | 11 | 46042 | 162 | 29528312 |
Renal failure | 29.89 | 14.15 | 299 | 45754 | 118300 | 29410174 |
Coma | 29.86 | 14.15 | 12 | 46041 | 39438 | 29489036 |
Delirium | 29.80 | 14.15 | 12 | 46041 | 39385 | 29489089 |
Feeding disorder | 29.70 | 14.15 | 41 | 46012 | 5826 | 29522648 |
Urticaria | 28.74 | 14.15 | 164 | 45889 | 54496 | 29473978 |
White blood cell count decreased | 28.51 | 14.15 | 54 | 45999 | 83308 | 29445166 |
Oedema peripheral | 28.16 | 14.15 | 76 | 45977 | 103481 | 29424993 |
Erythema | 27.07 | 14.15 | 206 | 45847 | 75400 | 29453074 |
Plasma cell myeloma | 26.95 | 14.15 | 12 | 46041 | 37103 | 29491371 |
Aggression | 26.59 | 14.15 | 11 | 46042 | 35530 | 29492944 |
Tuberculin test positive | 26.46 | 14.15 | 18 | 46035 | 1055 | 29527419 |
Feeling abnormal | 26.46 | 14.15 | 160 | 45893 | 54285 | 29474189 |
Sensitivity to weather change | 26.27 | 14.15 | 20 | 46033 | 1399 | 29527075 |
Rash vesicular | 26.10 | 14.15 | 25 | 46028 | 2393 | 29526081 |
Neutropenia | 26.05 | 14.15 | 111 | 45942 | 131600 | 29396874 |
Abdominal distension | 26.04 | 14.15 | 20 | 46033 | 45891 | 29482583 |
Abscess | 25.95 | 14.15 | 51 | 46002 | 9711 | 29518763 |
Gastrointestinal haemorrhage | 25.92 | 14.15 | 53 | 46000 | 79480 | 29448994 |
Respiratory failure | 25.88 | 14.15 | 72 | 45981 | 97059 | 29431415 |
Aortic bruit | 25.81 | 14.15 | 10 | 46043 | 174 | 29528300 |
Sacroiliitis | 25.66 | 14.15 | 18 | 46035 | 1109 | 29527365 |
Neck mass | 25.51 | 14.15 | 20 | 46033 | 1461 | 29527013 |
Medium-chain acyl-coenzyme A dehydrogenase deficiency | 25.46 | 14.15 | 7 | 46046 | 37 | 29528437 |
Wrist deformity | 25.45 | 14.15 | 12 | 46041 | 344 | 29528130 |
Angioedema | 25.34 | 14.15 | 9 | 46044 | 31906 | 29496568 |
Fragile X syndrome | 25.30 | 14.15 | 7 | 46046 | 38 | 29528436 |
Cutaneous symptom | 25.17 | 14.15 | 11 | 46042 | 263 | 29528211 |
Wrong technique in product usage process | 24.72 | 14.15 | 9 | 46044 | 31419 | 29497055 |
Cerebral haemorrhage | 24.71 | 14.15 | 9 | 46044 | 31417 | 29497057 |
Neck pain | 24.19 | 14.15 | 81 | 45972 | 21366 | 29507108 |
Epistaxis | 24.04 | 14.15 | 27 | 46026 | 51677 | 29476797 |
Nasopharyngitis | 23.89 | 14.15 | 167 | 45886 | 59498 | 29468976 |
Haemorrhage | 23.87 | 14.15 | 21 | 46032 | 45051 | 29483423 |
Ankle deformity | 23.82 | 14.15 | 10 | 46043 | 216 | 29528258 |
Depressed level of consciousness | 23.76 | 14.15 | 14 | 46039 | 36928 | 29491546 |
Loss of consciousness | 23.58 | 14.15 | 50 | 46003 | 74006 | 29454468 |
Joint ankylosis | 23.54 | 14.15 | 12 | 46041 | 409 | 29528065 |
Haematemesis | 23.17 | 14.15 | 5 | 46048 | 24621 | 29503853 |
Red blood cell sedimentation rate | 23.13 | 14.15 | 13 | 46040 | 541 | 29527933 |
Pneumonia | 22.89 | 14.15 | 356 | 45697 | 319816 | 29208658 |
Bone tuberculosis | 22.87 | 14.15 | 11 | 46042 | 330 | 29528144 |
Contraindication to medical treatment | 22.79 | 14.15 | 12 | 46041 | 438 | 29528036 |
Exostosis | 22.72 | 14.15 | 28 | 46025 | 3561 | 29524913 |
Splenic embolism | 22.70 | 14.15 | 9 | 46044 | 167 | 29528307 |
Stomatitis | 22.65 | 14.15 | 116 | 45937 | 36997 | 29491477 |
Trisomy 8 | 22.65 | 14.15 | 7 | 46046 | 59 | 29528415 |
Pyrexia | 22.57 | 14.15 | 314 | 45739 | 287308 | 29241166 |
Fibromyalgia | 22.54 | 14.15 | 24 | 46029 | 2605 | 29525869 |
Joint effusion | 22.33 | 14.15 | 30 | 46023 | 4154 | 29524320 |
Dysphagia | 22.10 | 14.15 | 32 | 46021 | 54894 | 29473580 |
Microcephaly | 21.94 | 14.15 | 14 | 46039 | 736 | 29527738 |
Oesophageal infection | 21.83 | 14.15 | 10 | 46043 | 268 | 29528206 |
Chronic kidney disease | 21.78 | 14.15 | 15 | 46038 | 36401 | 29492073 |
Ossicle disorder | 21.77 | 14.15 | 6 | 46047 | 32 | 29528442 |
Cardiac failure | 21.69 | 14.15 | 58 | 45995 | 79229 | 29449245 |
Cognitive disorder | 21.65 | 14.15 | 5 | 46048 | 23494 | 29504980 |
Hepatic failure | 21.64 | 14.15 | 11 | 46042 | 31501 | 29496973 |
Blood bilirubin increased | 21.58 | 14.15 | 13 | 46040 | 33880 | 29494594 |
Elbow operation | 21.56 | 14.15 | 8 | 46045 | 123 | 29528351 |
Therapy partial responder | 21.47 | 14.15 | 33 | 46020 | 5166 | 29523308 |
Swollen joint count increased | 21.38 | 14.15 | 8 | 46045 | 126 | 29528348 |
Cryopyrin associated periodic syndrome | 21.33 | 14.15 | 7 | 46046 | 73 | 29528401 |
Granuloma skin | 21.24 | 14.15 | 13 | 46040 | 635 | 29527839 |
Maternal exposure during pregnancy | 21.15 | 14.15 | 29 | 46024 | 4094 | 29524380 |
Neutrophil count decreased | 21.09 | 14.15 | 22 | 46031 | 43545 | 29484929 |
Diffuse idiopathic skeletal hyperostosis | 21.04 | 14.15 | 6 | 46047 | 37 | 29528437 |
Joint space narrowing | 20.99 | 14.15 | 7 | 46046 | 77 | 29528397 |
Pneumonia aspiration | 20.84 | 14.15 | 16 | 46037 | 36721 | 29491753 |
Sideroblastic anaemia | 20.84 | 14.15 | 9 | 46044 | 209 | 29528265 |
Enzyme abnormality | 20.50 | 14.15 | 8 | 46045 | 142 | 29528332 |
Stent placement | 20.18 | 14.15 | 29 | 46024 | 4277 | 29524197 |
Tender joint count increased | 20.03 | 14.15 | 6 | 46047 | 45 | 29528429 |
Headache | 19.95 | 14.15 | 381 | 45672 | 173626 | 29354848 |
Intentional product misuse | 19.78 | 14.15 | 15 | 46038 | 34646 | 29493828 |
Urinary tract infection | 19.74 | 14.15 | 53 | 46000 | 72301 | 29456173 |
Nephrolithiasis | 19.72 | 14.15 | 85 | 45968 | 25249 | 29503225 |
Intestinal diaphragm disease | 19.69 | 14.15 | 9 | 46044 | 240 | 29528234 |
Oral pustule | 19.62 | 14.15 | 9 | 46044 | 242 | 29528232 |
Transient ischaemic attack | 19.46 | 14.15 | 6 | 46047 | 23264 | 29505210 |
Vitamin B1 decreased | 19.45 | 14.15 | 9 | 46044 | 247 | 29528227 |
Therapeutic response decreased | 19.30 | 14.15 | 83 | 45970 | 24628 | 29503846 |
Blood urea increased | 19.02 | 14.15 | 10 | 46043 | 28102 | 29500372 |
Hepatic enzyme increased | 18.82 | 14.15 | 103 | 45950 | 33696 | 29494778 |
Acute lung injury | 18.75 | 14.15 | 16 | 46037 | 1317 | 29527157 |
C-reactive protein | 18.49 | 14.15 | 7 | 46046 | 114 | 29528360 |
Lacrimal duct neoplasm | 18.41 | 14.15 | 5 | 46048 | 25 | 29528449 |
Mantle cell lymphoma stage III | 18.41 | 14.15 | 5 | 46048 | 25 | 29528449 |
Blood parathyroid hormone decreased | 18.39 | 14.15 | 13 | 46040 | 811 | 29527663 |
Sitting disability | 18.22 | 14.15 | 7 | 46046 | 119 | 29528355 |
Memory impairment | 18.13 | 14.15 | 18 | 46035 | 36452 | 29492022 |
Diaphragmatic injury | 18.01 | 14.15 | 7 | 46046 | 123 | 29528351 |
Restlessness | 18 | 14.15 | 6 | 46047 | 22139 | 29506335 |
Panniculitis | 17.89 | 14.15 | 15 | 46038 | 1206 | 29527268 |
Disorientation | 17.86 | 14.15 | 12 | 46041 | 29503 | 29498971 |
Cardiogenic shock | 17.85 | 14.15 | 4 | 46049 | 19186 | 29509288 |
Hyperhidrosis | 17.81 | 14.15 | 47 | 46006 | 64493 | 29463981 |
Blood pressure decreased | 17.80 | 14.15 | 27 | 46026 | 45450 | 29483024 |
Spondylitis | 17.62 | 14.15 | 14 | 46039 | 1043 | 29527431 |
Muscle spasms | 17.50 | 14.15 | 48 | 46005 | 65034 | 29463440 |
Inflammatory pain | 17.45 | 14.15 | 7 | 46046 | 134 | 29528340 |
Anxiety | 17.44 | 14.15 | 71 | 45982 | 85294 | 29443180 |
Drug level increased | 17.30 | 14.15 | 4 | 46049 | 18783 | 29509691 |
Prostate cancer | 17.15 | 14.15 | 82 | 45971 | 25445 | 29503029 |
Bronchiectasis | 17.02 | 14.15 | 34 | 46019 | 6551 | 29521923 |
Encephalopathy | 17.00 | 14.15 | 14 | 46039 | 31029 | 29497445 |
Acute myocardial infarction | 16.88 | 14.15 | 31 | 46022 | 48407 | 29480067 |
Mixed connective tissue disease | 16.87 | 14.15 | 5 | 46048 | 36 | 29528438 |
Muscle strain | 16.86 | 14.15 | 24 | 46029 | 3509 | 29524965 |
Epilepsy | 16.83 | 14.15 | 4 | 46049 | 18428 | 29510046 |
Myalgia | 16.79 | 14.15 | 59 | 45994 | 73960 | 29454514 |
Hypersensitivity | 16.66 | 14.15 | 140 | 45913 | 52763 | 29475711 |
Lupus-like syndrome | 16.55 | 14.15 | 19 | 46034 | 2243 | 29526231 |
Haemoptysis | 16.46 | 14.15 | 14 | 46039 | 30536 | 29497938 |
Skin laceration | 16.42 | 14.15 | 46 | 46007 | 11016 | 29517458 |
Thrombocytosis | 16.33 | 14.15 | 23 | 46030 | 3330 | 29525144 |
Localised infection | 16.31 | 14.15 | 53 | 46000 | 13763 | 29514711 |
Osteonecrosis of jaw | 16.27 | 14.15 | 3 | 46050 | 16507 | 29511967 |
Pulmonary mass | 16.25 | 14.15 | 45 | 46008 | 10703 | 29517771 |
Urinary incontinence | 16.23 | 14.15 | 3 | 46050 | 16478 | 29511996 |
Raoultella ornithinolytica infection | 16.10 | 14.15 | 4 | 46049 | 13 | 29528461 |
Pancreatitis acute | 16.02 | 14.15 | 9 | 46044 | 24376 | 29504098 |
Generalised tonic-clonic seizure | 15.88 | 14.15 | 5 | 46048 | 19134 | 29509340 |
Hyperglycaemia | 15.83 | 14.15 | 18 | 46035 | 34269 | 29494205 |
Hepatic cirrhosis | 15.80 | 14.15 | 54 | 45999 | 14390 | 29514084 |
Rheumatoid lung | 15.70 | 14.15 | 9 | 46044 | 389 | 29528085 |
Seborrhoeic dermatitis | 15.64 | 14.15 | 15 | 46038 | 1438 | 29527036 |
Squamous cell carcinoma | 15.58 | 14.15 | 43 | 46010 | 10208 | 29518266 |
Physical disability | 15.53 | 14.15 | 14 | 46039 | 1240 | 29527234 |
Spinal cord oedema | 15.44 | 14.15 | 7 | 46046 | 183 | 29528291 |
Epstein Barr virus positive mucocutaneous ulcer | 15.40 | 14.15 | 8 | 46045 | 284 | 29528190 |
Cholestasis | 14.93 | 14.15 | 9 | 46044 | 23453 | 29505021 |
Inflammatory marker increased | 14.76 | 14.15 | 23 | 46030 | 3644 | 29524830 |
Haematuria | 14.73 | 14.15 | 29 | 46024 | 44110 | 29484364 |
Arthritis infective | 14.69 | 14.15 | 20 | 46033 | 2804 | 29525670 |
Joint contracture | 14.68 | 14.15 | 16 | 46037 | 1784 | 29526690 |
Axillary pain | 14.59 | 14.15 | 8 | 46045 | 317 | 29528157 |
Liver disorder | 14.41 | 14.15 | 83 | 45970 | 27666 | 29500808 |
Acne | 14.34 | 14.15 | 39 | 46014 | 9181 | 29519293 |
Mycobacterial infection | 14.27 | 14.15 | 16 | 46037 | 1840 | 29526634 |
Bursa removal | 14.23 | 14.15 | 6 | 46047 | 131 | 29528343 |
Full blood count abnormal | 14.22 | 14.15 | 3 | 46050 | 15010 | 29513464 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug ineffective | 4806.23 | 13.32 | 9295 | 204099 | 830952 | 63454386 |
Drug intolerance | 4566.77 | 13.32 | 4248 | 209146 | 183744 | 64101594 |
Joint swelling | 2991.30 | 13.32 | 3617 | 209777 | 211765 | 64073573 |
Contraindicated product administered | 2932.79 | 13.32 | 2600 | 210794 | 105229 | 64180109 |
Synovitis | 2657.80 | 13.32 | 2371 | 211023 | 96719 | 64188619 |
Treatment failure | 2637.89 | 13.32 | 2539 | 210855 | 114277 | 64171061 |
Therapeutic product effect decreased | 1838.79 | 13.32 | 2082 | 211312 | 113269 | 64172069 |
Arthropathy | 1829.94 | 13.32 | 2125 | 211269 | 118842 | 64166496 |
Hand deformity | 1480.64 | 13.32 | 1399 | 211995 | 61372 | 64223966 |
Systemic lupus erythematosus | 1473.90 | 13.32 | 1537 | 211857 | 76075 | 64209263 |
Pemphigus | 1420.50 | 13.32 | 1347 | 212047 | 59354 | 64225984 |
Drug hypersensitivity | 1284.28 | 13.32 | 2585 | 210809 | 235230 | 64050108 |
Rheumatoid arthritis | 1248.30 | 13.32 | 2071 | 211323 | 162223 | 64123115 |
Abdominal discomfort | 1241.61 | 13.32 | 2189 | 211205 | 180133 | 64105205 |
C-reactive protein abnormal | 1219.88 | 13.32 | 904 | 212490 | 28143 | 64257195 |
Glossodynia | 1191.96 | 13.32 | 1261 | 212133 | 63435 | 64221903 |
Pain | 1179.22 | 13.32 | 4257 | 209137 | 549254 | 63736084 |
Anti-cyclic citrullinated peptide antibody positive | 1163.53 | 13.32 | 1102 | 212292 | 48460 | 64236878 |
Musculoskeletal stiffness | 1159.34 | 13.32 | 1714 | 211680 | 121492 | 64163846 |
Arthralgia | 1138.86 | 13.32 | 3626 | 209768 | 438634 | 63846704 |
Rheumatoid factor positive | 1097.17 | 13.32 | 916 | 212478 | 34022 | 64251316 |
Swelling | 1049.75 | 13.32 | 1892 | 211502 | 158326 | 64127012 |
Alopecia | 1044.32 | 13.32 | 1924 | 211470 | 163766 | 64121572 |
Therapeutic product effect incomplete | 1012.95 | 13.32 | 1467 | 211927 | 102015 | 64183323 |
Pericarditis | 952.00 | 13.32 | 1103 | 212291 | 61413 | 64223925 |
Hepatic enzyme increased | 923.95 | 13.32 | 1591 | 211803 | 128352 | 64156986 |
Death | 908.41 | 13.32 | 239 | 213155 | 482466 | 63802872 |
Loss of personal independence in daily activities | 899.66 | 13.32 | 1153 | 212241 | 71301 | 64214037 |
Wound | 830.91 | 13.32 | 1140 | 212254 | 75337 | 64210001 |
Red blood cell sedimentation rate increased | 783.86 | 13.32 | 721 | 212673 | 30514 | 64254824 |
Acute kidney injury | 764.43 | 13.32 | 267 | 213127 | 448973 | 63836365 |
Hypersensitivity | 752.22 | 13.32 | 1863 | 211531 | 194589 | 64090749 |
Psoriatic arthropathy | 751.76 | 13.32 | 818 | 212576 | 42463 | 64242875 |
Red blood cell sedimentation rate abnormal | 694.59 | 13.32 | 512 | 212882 | 15794 | 64269544 |
Discomfort | 693.24 | 13.32 | 1078 | 212316 | 79800 | 64205538 |
Sleep disorder due to general medical condition, insomnia type | 679.86 | 13.32 | 617 | 212777 | 25653 | 64259685 |
C-reactive protein increased | 676.78 | 13.32 | 1164 | 212230 | 93745 | 64191593 |
Completed suicide | 670.19 | 13.32 | 15 | 213379 | 224399 | 64060939 |
Condition aggravated | 656.92 | 13.32 | 2702 | 210692 | 369724 | 63915614 |
Infusion related reaction | 645.56 | 13.32 | 1575 | 211819 | 162892 | 64122446 |
Duodenal ulcer perforation | 633.95 | 13.32 | 673 | 212721 | 33952 | 64251386 |
Toxicity to various agents | 612.95 | 13.32 | 219 | 213175 | 363294 | 63922044 |
Helicobacter infection | 602.54 | 13.32 | 688 | 212706 | 37674 | 64247664 |
Hypotension | 579.84 | 13.32 | 268 | 213126 | 380706 | 63904632 |
Anaemia | 563.10 | 13.32 | 275 | 213119 | 378405 | 63906933 |
Drug interaction | 561.49 | 13.32 | 248 | 213146 | 361835 | 63923503 |
Peripheral swelling | 505.31 | 13.32 | 1681 | 211713 | 207472 | 64077866 |
Bone erosion | 480.18 | 13.32 | 358 | 213036 | 11237 | 64274101 |
Mobility decreased | 465.31 | 13.32 | 936 | 212458 | 84904 | 64200434 |
Product use issue | 454.01 | 13.32 | 1314 | 212080 | 150401 | 64134937 |
Rash | 441.22 | 13.32 | 2807 | 210587 | 455742 | 63829596 |
Febrile neutropenia | 428.49 | 13.32 | 57 | 213337 | 187600 | 64097738 |
Maternal exposure during pregnancy | 420.10 | 13.32 | 959 | 212435 | 94925 | 64190413 |
Infection | 414.85 | 13.32 | 1450 | 211944 | 183430 | 64101908 |
Dehydration | 413.23 | 13.32 | 104 | 213290 | 216659 | 64068679 |
Knee arthroplasty | 411.76 | 13.32 | 477 | 212917 | 26522 | 64258816 |
Drug abuse | 402.44 | 13.32 | 7 | 213387 | 132367 | 64152971 |
Rheumatoid nodule | 395.52 | 13.32 | 331 | 213063 | 12320 | 64273018 |
Thrombocytopenia | 378.25 | 13.32 | 134 | 213260 | 223667 | 64061671 |
Irritable bowel syndrome | 374.24 | 13.32 | 536 | 212858 | 36833 | 64248505 |
Osteoarthritis | 371.46 | 13.32 | 714 | 212680 | 62622 | 64222716 |
Gastrointestinal disorder | 365.35 | 13.32 | 872 | 212522 | 88837 | 64196501 |
Muscle injury | 365.07 | 13.32 | 444 | 212950 | 25993 | 64259345 |
Disability | 361.09 | 13.32 | 309 | 213085 | 11863 | 64273475 |
Cardiac arrest | 356.00 | 13.32 | 45 | 213349 | 154019 | 64131319 |
Inflammation | 353.75 | 13.32 | 712 | 212682 | 64588 | 64220750 |
Constipation | 352.12 | 13.32 | 159 | 213235 | 229178 | 64056160 |
Arthritis | 345.96 | 13.32 | 819 | 212575 | 82995 | 64202343 |
Folliculitis | 333.39 | 13.32 | 453 | 212941 | 29624 | 64255714 |
Hip arthroplasty | 331.93 | 13.32 | 381 | 213013 | 20970 | 64264368 |
Seizure | 318.14 | 13.32 | 80 | 213314 | 166812 | 64118526 |
Malignant neoplasm progression | 313.77 | 13.32 | 14 | 213380 | 112857 | 64172481 |
Blood parathyroid hormone decreased | 306.27 | 13.32 | 228 | 213166 | 7138 | 64278200 |
Atrial fibrillation | 300.23 | 13.32 | 96 | 213298 | 170993 | 64114345 |
Drug tolerance decreased | 298.58 | 13.32 | 220 | 213174 | 6778 | 64278560 |
Granuloma skin | 295.95 | 13.32 | 207 | 213187 | 5867 | 64279471 |
Dyspnoea | 290.11 | 13.32 | 1309 | 212085 | 717365 | 63567973 |
Hyperkalaemia | 289.73 | 13.32 | 10 | 213384 | 101119 | 64184219 |
Ankylosing spondylitis | 288 | 13.32 | 230 | 213164 | 8004 | 64277334 |
Somnolence | 287.24 | 13.32 | 158 | 213236 | 203487 | 64081851 |
Panniculitis | 278.98 | 13.32 | 233 | 213161 | 8646 | 64276692 |
Hyponatraemia | 277.18 | 13.32 | 74 | 213320 | 148265 | 64137073 |
Bradycardia | 276.84 | 13.32 | 33 | 213361 | 118186 | 64167152 |
Cardio-respiratory arrest | 270.90 | 13.32 | 13 | 213381 | 98380 | 64186958 |
Enthesopathy | 270.37 | 13.32 | 237 | 213157 | 9401 | 64275937 |
Impaired healing | 269.36 | 13.32 | 609 | 212785 | 59864 | 64225474 |
Fall | 268.81 | 13.32 | 615 | 212779 | 416211 | 63869127 |
Grip strength decreased | 267.87 | 13.32 | 257 | 213137 | 11467 | 64273871 |
Asthenia | 267.69 | 13.32 | 642 | 212752 | 427402 | 63857936 |
Neutropenia | 265.54 | 13.32 | 241 | 213153 | 239383 | 64045955 |
Platelet count decreased | 245.50 | 13.32 | 124 | 213270 | 167587 | 64117751 |
Respiratory failure | 243.80 | 13.32 | 114 | 213280 | 161069 | 64124269 |
Tenosynovitis | 236.24 | 13.32 | 241 | 213153 | 11592 | 64273746 |
Overdose | 235.03 | 13.32 | 117 | 213277 | 159449 | 64125889 |
Polyarthritis | 231.55 | 13.32 | 218 | 213176 | 9497 | 64275841 |
Cardiac failure congestive | 231.32 | 13.32 | 72 | 213322 | 130508 | 64154830 |
Rhabdomyolysis | 229.27 | 13.32 | 20 | 213374 | 91706 | 64193632 |
Blister | 226.42 | 13.32 | 685 | 212709 | 80282 | 64205056 |
Gastrointestinal haemorrhage | 225.51 | 13.32 | 78 | 213316 | 132234 | 64153104 |
Anxiety | 219.52 | 13.32 | 208 | 213186 | 202441 | 64082897 |
Oedema peripheral | 218.46 | 13.32 | 224 | 213170 | 210093 | 64075245 |
Hypoglycaemia | 215.71 | 13.32 | 23 | 213371 | 89869 | 64195469 |
Cerebrovascular accident | 214.81 | 13.32 | 93 | 213301 | 137490 | 64147848 |
Ill-defined disorder | 213.53 | 13.32 | 459 | 212935 | 43593 | 64241745 |
Electrocardiogram QT prolonged | 210.91 | 13.32 | 13 | 213381 | 79435 | 64205903 |
Joint stiffness | 210.06 | 13.32 | 368 | 213026 | 30036 | 64255302 |
Tremor | 208.96 | 13.32 | 115 | 213279 | 148115 | 64137223 |
Cardiac failure | 205.83 | 13.32 | 90 | 213304 | 132283 | 64153055 |
Tachycardia | 205.19 | 13.32 | 120 | 213274 | 149459 | 64135879 |
Musculoskeletal pain | 202.69 | 13.32 | 661 | 212733 | 80633 | 64204705 |
Transplant dysfunction | 202.45 | 13.32 | 172 | 213222 | 6536 | 64278802 |
Depressed level of consciousness | 200.19 | 13.32 | 19 | 213375 | 81417 | 64203921 |
Disease progression | 198.15 | 13.32 | 111 | 213283 | 141569 | 64143769 |
Hypokalaemia | 197.41 | 13.32 | 78 | 213316 | 121825 | 64163513 |
Dizziness | 191.26 | 13.32 | 754 | 212640 | 429409 | 63855929 |
International normalised ratio increased | 190.62 | 13.32 | 20 | 213374 | 79147 | 64206191 |
Hypoxia | 186.89 | 13.32 | 33 | 213361 | 88116 | 64197222 |
Agitation | 181.12 | 13.32 | 36 | 213358 | 88331 | 64197007 |
Syncope | 180.00 | 13.32 | 154 | 213240 | 157481 | 64127857 |
Multiple organ dysfunction syndrome | 177.67 | 13.32 | 57 | 213337 | 101356 | 64183982 |
Joint range of motion decreased | 175.63 | 13.32 | 265 | 213129 | 19078 | 64266260 |
Joint destruction | 175.01 | 13.32 | 123 | 213271 | 3513 | 64281825 |
Fibromyalgia | 173.97 | 13.32 | 373 | 213021 | 35358 | 64249980 |
Apparent death | 173.53 | 13.32 | 109 | 213285 | 2567 | 64282771 |
Lactic acidosis | 172.69 | 13.32 | 7 | 213387 | 61403 | 64223935 |
Deformity | 170.95 | 13.32 | 152 | 213242 | 6145 | 64279193 |
Coma | 168.83 | 13.32 | 41 | 213353 | 87574 | 64197764 |
Ovarian cyst | 168.52 | 13.32 | 195 | 213199 | 10823 | 64274515 |
Adverse event | 168.42 | 13.32 | 391 | 213003 | 39098 | 64246240 |
Swollen joint count increased | 165.25 | 13.32 | 163 | 213231 | 7526 | 64277812 |
Suicide attempt | 163.32 | 13.32 | 21 | 213373 | 70986 | 64214352 |
Metabolic acidosis | 163.18 | 13.32 | 21 | 213373 | 70937 | 64214401 |
Skin necrosis | 162.08 | 13.32 | 218 | 213176 | 14111 | 64271227 |
Lower respiratory tract infection | 160.89 | 13.32 | 680 | 212714 | 93934 | 64191404 |
Rheumatic fever | 156.64 | 13.32 | 173 | 213221 | 9121 | 64276217 |
Mental status changes | 153.75 | 13.32 | 13 | 213381 | 61149 | 64224189 |
Breast cancer stage III | 153.30 | 13.32 | 104 | 213290 | 2801 | 64282537 |
Diarrhoea | 153.03 | 13.32 | 1592 | 211802 | 721112 | 63564226 |
Impaired work ability | 151.89 | 13.32 | 218 | 213176 | 15001 | 64270337 |
Foot deformity | 151.12 | 13.32 | 227 | 213167 | 16277 | 64269061 |
Nasopharyngitis | 150.88 | 13.32 | 1138 | 212256 | 194935 | 64090403 |
Ulcer | 150.75 | 13.32 | 272 | 213122 | 22718 | 64262620 |
Liver function test increased | 149.28 | 13.32 | 322 | 213072 | 30648 | 64254690 |
Epistaxis | 147.42 | 13.32 | 70 | 213324 | 98061 | 64187277 |
Stomatitis | 147.23 | 13.32 | 735 | 212659 | 108870 | 64176468 |
Vomiting | 146.24 | 13.32 | 1146 | 212248 | 549971 | 63735367 |
Intentional product use issue | 144.38 | 13.32 | 662 | 212732 | 94702 | 64190636 |
Musculoskeletal disorder | 142.65 | 13.32 | 231 | 213163 | 17675 | 64267663 |
Product dose omission issue | 142.44 | 13.32 | 267 | 213127 | 194480 | 64090858 |
Decreased appetite | 141.44 | 13.32 | 468 | 212926 | 280821 | 64004517 |
Sinusitis | 141.23 | 13.32 | 896 | 212498 | 145032 | 64140306 |
Unresponsive to stimuli | 140.84 | 13.32 | 6 | 213388 | 50387 | 64234951 |
White blood cell count decreased | 140.37 | 13.32 | 190 | 213204 | 157647 | 64127691 |
Hallucination | 140.36 | 13.32 | 34 | 213360 | 72754 | 64212584 |
Musculoskeletal deformity | 138.21 | 13.32 | 59 | 213335 | 595 | 64284743 |
Respiratory distress | 137.59 | 13.32 | 9 | 213385 | 52322 | 64233016 |
Balance disorder | 135.36 | 13.32 | 54 | 213340 | 83872 | 64201466 |
Seronegative arthritis | 134.84 | 13.32 | 94 | 213300 | 2649 | 64282689 |
Chest pain | 134.10 | 13.32 | 371 | 213023 | 235609 | 64049729 |
Human antichimeric antibody positive | 132.16 | 13.32 | 73 | 213321 | 1343 | 64283995 |
Respiratory arrest | 131.18 | 13.32 | 12 | 213382 | 52973 | 64232365 |
Sepsis | 130.98 | 13.32 | 362 | 213032 | 229979 | 64055359 |
Cognitive disorder | 129.86 | 13.32 | 15 | 213379 | 55072 | 64230266 |
Disorientation | 129.64 | 13.32 | 16 | 213378 | 55812 | 64229526 |
Hyperglycaemia | 128.85 | 13.32 | 23 | 213371 | 60945 | 64224393 |
Vision blurred | 128.80 | 13.32 | 69 | 213325 | 90247 | 64195091 |
Renal failure | 124.32 | 13.32 | 259 | 213135 | 181429 | 64103909 |
Dysphagia | 123.55 | 13.32 | 103 | 213291 | 106709 | 64178629 |
Body height below normal | 122.80 | 13.32 | 76 | 213318 | 1742 | 64283596 |
Encephalopathy | 122.56 | 13.32 | 23 | 213371 | 58796 | 64226542 |
Urinary tract infection | 122.21 | 13.32 | 377 | 213017 | 231219 | 64054119 |
Blood creatine phosphokinase increased | 121.79 | 13.32 | 23 | 213371 | 58535 | 64226803 |
Diverticulitis | 121.62 | 13.32 | 341 | 213053 | 38277 | 64247061 |
Hyperhidrosis | 119.77 | 13.32 | 142 | 213252 | 124778 | 64160560 |
Multiple sclerosis relapse | 118.03 | 13.32 | 4 | 213390 | 41131 | 64244207 |
Therapeutic response decreased | 117.37 | 13.32 | 410 | 212984 | 51778 | 64233560 |
Pneumonia aspiration | 115.63 | 13.32 | 27 | 213367 | 59244 | 64226094 |
Nodule | 114.70 | 13.32 | 210 | 213184 | 17737 | 64267601 |
Neutrophil count decreased | 114.52 | 13.32 | 56 | 213338 | 77140 | 64208198 |
Alanine aminotransferase abnormal | 113.99 | 13.32 | 127 | 213267 | 6761 | 64278577 |
Acne | 113.56 | 13.32 | 242 | 213152 | 22839 | 64262499 |
Sciatica | 113.31 | 13.32 | 224 | 213170 | 20040 | 64265298 |
Hypervolaemia | 112.47 | 13.32 | 3 | 213391 | 38282 | 64247056 |
Dysarthria | 110.22 | 13.32 | 30 | 213364 | 59376 | 64225962 |
Pneumonia | 109.67 | 13.32 | 1254 | 212140 | 558322 | 63727016 |
Pancytopenia | 109.66 | 13.32 | 191 | 213203 | 143118 | 64142220 |
Red blood cell sedimentation rate | 109.56 | 13.32 | 94 | 213300 | 3620 | 64281718 |
Sedation | 109.39 | 13.32 | 7 | 213387 | 41455 | 64243883 |
Abdominal pain | 109.32 | 13.32 | 597 | 212797 | 311778 | 63973560 |
Blood glucose increased | 109.27 | 13.32 | 98 | 213296 | 97975 | 64187363 |
Drug eruption | 108.85 | 13.32 | 314 | 213080 | 35822 | 64249516 |
Psoriasis | 108.69 | 13.32 | 498 | 212896 | 71205 | 64214133 |
Haemorrhage | 106.89 | 13.32 | 65 | 213329 | 79286 | 64206052 |
Hepatic failure | 106.55 | 13.32 | 26 | 213368 | 55368 | 64229970 |
Intentional product misuse | 106.40 | 13.32 | 53 | 213341 | 72242 | 64213096 |
Cerebral haemorrhage | 106.40 | 13.32 | 20 | 213374 | 51070 | 64234268 |
Muscle spasms | 106.06 | 13.32 | 190 | 213204 | 140833 | 64144505 |
Basal cell carcinoma | 105.79 | 13.32 | 281 | 213113 | 30557 | 64254781 |
Serotonin syndrome | 105.55 | 13.32 | 6 | 213388 | 39276 | 64246062 |
Adverse drug reaction | 104.69 | 13.32 | 360 | 213034 | 45104 | 64240234 |
Dislocation of vertebra | 104.45 | 13.32 | 85 | 213309 | 3039 | 64282299 |
Pulmonary oedema | 103.82 | 13.32 | 66 | 213328 | 78608 | 64206730 |
Wrong technique in product usage process | 102.84 | 13.32 | 43 | 213351 | 64931 | 64220407 |
Myalgia | 102.80 | 13.32 | 233 | 213161 | 158384 | 64126954 |
Neoplasm progression | 102.16 | 13.32 | 9 | 213385 | 40955 | 64244383 |
Chest discomfort | 101.96 | 13.32 | 141 | 213253 | 115965 | 64169373 |
Blood bilirubin increased | 101.40 | 13.32 | 32 | 213362 | 57521 | 64227817 |
Acute myocardial infarction | 101.27 | 13.32 | 52 | 213342 | 69666 | 64215672 |
Aggression | 100.88 | 13.32 | 16 | 213378 | 46216 | 64239122 |
Joint effusion | 100.84 | 13.32 | 169 | 213225 | 13304 | 64272034 |
Finger deformity | 100.58 | 13.32 | 104 | 213290 | 5082 | 64280256 |
Orthostatic hypotension | 100.14 | 13.32 | 17 | 213377 | 46721 | 64238617 |
Tongue disorder | 97.81 | 13.32 | 157 | 213237 | 11923 | 64273415 |
Acute respiratory failure | 96.91 | 13.32 | 23 | 213371 | 49911 | 64235427 |
Fluid retention | 96.69 | 13.32 | 38 | 213356 | 59568 | 64225770 |
Physical disability | 95.60 | 13.32 | 71 | 213323 | 2214 | 64283124 |
Tenderness | 94.68 | 13.32 | 204 | 213190 | 19398 | 64265940 |
Skin ulcer | 94.19 | 13.32 | 340 | 213054 | 43634 | 64241704 |
Abnormal behaviour | 93.96 | 13.32 | 4 | 213390 | 33618 | 64251720 |
Hypomagnesaemia | 93.79 | 13.32 | 8 | 213386 | 37368 | 64247970 |
Blood cholesterol increased | 93.10 | 13.32 | 370 | 213024 | 49696 | 64235642 |
Blood urea increased | 92.55 | 13.32 | 17 | 213377 | 44136 | 64241202 |
Melaena | 92.18 | 13.32 | 31 | 213363 | 53517 | 64231821 |
Plasma cell myeloma | 91.86 | 13.32 | 20 | 213374 | 46055 | 64239283 |
Loss of consciousness | 90.52 | 13.32 | 225 | 213169 | 148140 | 64137198 |
Dyspnoea exertional | 90.43 | 13.32 | 67 | 213327 | 73663 | 64211675 |
Ascites | 90.42 | 13.32 | 46 | 213348 | 61955 | 64223383 |
Paraesthesia | 90.12 | 13.32 | 194 | 213200 | 134328 | 64151010 |
Restlessness | 88.57 | 13.32 | 13 | 213381 | 39772 | 64245566 |
Blood pressure decreased | 88.06 | 13.32 | 93 | 213301 | 86106 | 64199232 |
Haematuria | 87.99 | 13.32 | 45 | 213349 | 60426 | 64224912 |
Contusion | 87.87 | 13.32 | 662 | 212732 | 113303 | 64172035 |
Blood creatinine increased | 87.54 | 13.32 | 200 | 213194 | 135582 | 64149756 |
Fine motor skill dysfunction | 87.13 | 13.32 | 92 | 213302 | 4607 | 64280731 |
Pain in extremity | 86.89 | 13.32 | 1447 | 211947 | 301638 | 63983700 |
Transient ischaemic attack | 86.43 | 13.32 | 20 | 213374 | 44162 | 64241176 |
Tendonitis | 85.56 | 13.32 | 200 | 213194 | 20082 | 64265256 |
Pulmonary hypertension | 85.45 | 13.32 | 19 | 213375 | 43120 | 64242218 |
Onychomycosis | 84.61 | 13.32 | 95 | 213299 | 5101 | 64280237 |
Terminal state | 84.17 | 13.32 | 88 | 213306 | 4356 | 64280982 |
Presbyacusis | 83.86 | 13.32 | 69 | 213325 | 2506 | 64282832 |
Exostosis | 83.65 | 13.32 | 142 | 213252 | 11296 | 64274042 |
Coronary artery disease | 82.09 | 13.32 | 49 | 213345 | 60384 | 64224954 |
Haemoglobin decreased | 82.03 | 13.32 | 349 | 213045 | 194714 | 64090624 |
Sleep disorder | 81.26 | 13.32 | 402 | 212992 | 59307 | 64226031 |
Aphasia | 81.06 | 13.32 | 18 | 213376 | 40888 | 64244450 |
Pulmonary embolism | 80.93 | 13.32 | 233 | 213161 | 146123 | 64139215 |
Pleural effusion | 80.30 | 13.32 | 188 | 213206 | 126371 | 64158967 |
Generalised tonic-clonic seizure | 80.07 | 13.32 | 17 | 213377 | 39840 | 64245498 |
Neoplasm malignant | 79.71 | 13.32 | 220 | 213174 | 24468 | 64260870 |
Hypophagia | 79.29 | 13.32 | 17 | 213377 | 39570 | 64245768 |
Nail disorder | 78.07 | 13.32 | 118 | 213276 | 8506 | 64276832 |
Bone density abnormal | 77.99 | 13.32 | 68 | 213326 | 2677 | 64282661 |
Type 2 diabetes mellitus | 77.98 | 13.32 | 269 | 213125 | 33751 | 64251587 |
Fear of injection | 77.89 | 13.32 | 97 | 213297 | 5815 | 64279523 |
Disturbance in attention | 77.60 | 13.32 | 20 | 213374 | 41054 | 64244284 |
Neurotoxicity | 77.46 | 13.32 | 3 | 213391 | 27401 | 64257937 |
Chronic kidney disease | 77.23 | 13.32 | 48 | 213346 | 57871 | 64227467 |
Dactylitis | 76.15 | 13.32 | 58 | 213336 | 1880 | 64283458 |
Blood potassium decreased | 75.70 | 13.32 | 20 | 213374 | 40379 | 64244959 |
Fatigue | 75.66 | 13.32 | 3110 | 210284 | 745620 | 63539718 |
Wrist deformity | 75.46 | 13.32 | 56 | 213338 | 1744 | 64283594 |
Muscular weakness | 75.43 | 13.32 | 196 | 213198 | 127142 | 64158196 |
Confusional state | 75.25 | 13.32 | 530 | 212864 | 260614 | 64024724 |
Pleural thickening | 74.72 | 13.32 | 66 | 213328 | 2644 | 64282694 |
Altered state of consciousness | 74.46 | 13.32 | 17 | 213377 | 37885 | 64247453 |
Osteonecrosis of jaw | 74.09 | 13.32 | 20 | 213374 | 39805 | 64245533 |
Hepatic enzyme abnormal | 74.06 | 13.32 | 94 | 213300 | 5745 | 64279593 |
Urinary retention | 74.02 | 13.32 | 35 | 213359 | 49166 | 64236172 |
Lethargy | 73.40 | 13.32 | 79 | 213315 | 72515 | 64212823 |
Dyskinesia | 72.86 | 13.32 | 20 | 213374 | 39368 | 64245970 |
Transplant rejection | 72.76 | 13.32 | 171 | 213223 | 17230 | 64268108 |
Gastric disorder | 72.35 | 13.32 | 237 | 213157 | 28960 | 64256378 |
Chronic obstructive pulmonary disease | 72.19 | 13.32 | 77 | 213317 | 70971 | 64214367 |
Drug level increased | 72.03 | 13.32 | 13 | 213381 | 34183 | 64251155 |
Neck deformity | 71.19 | 13.32 | 53 | 213341 | 1659 | 64283679 |
Haematoma | 70.98 | 13.32 | 32 | 213362 | 46218 | 64239120 |
Drug reaction with eosinophilia and systemic symptoms | 70.93 | 13.32 | 361 | 213033 | 53856 | 64231482 |
Intestinal sepsis | 70.86 | 13.32 | 37 | 213357 | 605 | 64284733 |
Infusion site reaction | 70.25 | 13.32 | 57 | 213337 | 2029 | 64283309 |
Myoclonus | 70.15 | 13.32 | 3 | 213391 | 25115 | 64260223 |
Epilepsy | 70.09 | 13.32 | 13 | 213381 | 33518 | 64251820 |
Dysgeusia | 69.97 | 13.32 | 34 | 213360 | 47013 | 64238325 |
Thyroid neoplasm | 69.87 | 13.32 | 63 | 213331 | 2594 | 64282744 |
Cardiogenic shock | 69.02 | 13.32 | 12 | 213382 | 32415 | 64252923 |
Myocardial infarction | 68.89 | 13.32 | 298 | 213096 | 165523 | 64119815 |
Wheelchair user | 68.63 | 13.32 | 81 | 213313 | 4591 | 64280747 |
COVID-19 | 67.98 | 13.32 | 69 | 213325 | 65071 | 64220267 |
Dysuria | 67.90 | 13.32 | 27 | 213367 | 42030 | 64243308 |
Drug withdrawal syndrome | 67.89 | 13.32 | 11 | 213383 | 31280 | 64254058 |
Bone swelling | 67.65 | 13.32 | 45 | 213349 | 1172 | 64284166 |
Ejection fraction decreased | 67.20 | 13.32 | 8 | 213386 | 28699 | 64256639 |
Pyrexia | 67.08 | 13.32 | 1375 | 212019 | 557269 | 63728069 |
Blood iron abnormal | 67.00 | 13.32 | 44 | 213350 | 1121 | 64284217 |
Psychotic disorder | 66.95 | 13.32 | 16 | 213378 | 34562 | 64250776 |
Haematemesis | 66.86 | 13.32 | 36 | 213358 | 46963 | 64238375 |
Adverse reaction | 66.51 | 13.32 | 103 | 213291 | 7584 | 64277754 |
Abdominal distension | 66.33 | 13.32 | 136 | 213258 | 95858 | 64189480 |
International normalised ratio fluctuation | 65.92 | 13.32 | 64 | 213330 | 2897 | 64282441 |
Pleural fibrosis | 65.86 | 13.32 | 74 | 213320 | 3976 | 64281362 |
Pulmonary thrombosis | 65.86 | 13.32 | 122 | 213272 | 10396 | 64274942 |
Ischaemic stroke | 65.77 | 13.32 | 9 | 213385 | 29026 | 64256312 |
Immobile | 65.73 | 13.32 | 90 | 213304 | 5925 | 64279413 |
Irritability | 65.50 | 13.32 | 20 | 213374 | 36726 | 64248612 |
Renal impairment | 65.48 | 13.32 | 228 | 213166 | 134789 | 64150549 |
Spinal stenosis | 65.02 | 13.32 | 143 | 213251 | 13788 | 64271550 |
Ventricular tachycardia | 64.13 | 13.32 | 17 | 213377 | 34248 | 64251090 |
Urinary incontinence | 63.86 | 13.32 | 20 | 213374 | 36131 | 64249207 |
Pancreatitis acute | 63.68 | 13.32 | 31 | 213363 | 42824 | 64242514 |
Bone marrow failure | 63.57 | 13.32 | 40 | 213354 | 47912 | 64237426 |
Hospitalisation | 63.38 | 13.32 | 94 | 213300 | 75113 | 64210225 |
Antibody test positive | 63.16 | 13.32 | 57 | 213337 | 2350 | 64282988 |
Haemorrhage intracranial | 63.10 | 13.32 | 4 | 213390 | 23880 | 64261458 |
Upper gastrointestinal haemorrhage | 63.09 | 13.32 | 19 | 213375 | 35201 | 64250137 |
Clostridium difficile colitis | 62.71 | 13.32 | 8 | 213386 | 27215 | 64258123 |
Ovarian neoplasm | 62.64 | 13.32 | 33 | 213361 | 550 | 64284788 |
Arthrodesis | 62.37 | 13.32 | 53 | 213341 | 2014 | 64283324 |
Coeliac disease | 62.30 | 13.32 | 98 | 213296 | 7314 | 64278024 |
Haemoptysis | 62.20 | 13.32 | 43 | 213351 | 49005 | 64236333 |
Pulmonary arterial hypertension | 62.11 | 13.32 | 6 | 213388 | 25361 | 64259977 |
Drug specific antibody | 61.75 | 13.32 | 53 | 213341 | 2042 | 64283296 |
Hypercalcaemia | 61.51 | 13.32 | 236 | 213158 | 31180 | 64254158 |
Obstructive airways disorder | 60.91 | 13.32 | 4 | 213390 | 23181 | 64262157 |
Mycotic allergy | 60.60 | 13.32 | 39 | 213355 | 959 | 64284379 |
Anti-cyclic citrullinated peptide antibody | 60.20 | 13.32 | 44 | 213350 | 1338 | 64284000 |
Sinus tachycardia | 60.19 | 13.32 | 16 | 213378 | 32172 | 64253166 |
Bloody discharge | 59.80 | 13.32 | 45 | 213349 | 1432 | 64283906 |
Product quality issue | 59.27 | 13.32 | 13 | 213381 | 29786 | 64255552 |
Subdural haematoma | 58.37 | 13.32 | 11 | 213383 | 28043 | 64257295 |
Lymphocyte count decreased | 58.15 | 13.32 | 31 | 213363 | 40668 | 64244670 |
Shock | 57.84 | 13.32 | 27 | 213367 | 38213 | 64247125 |
Osteopenia | 57.81 | 13.32 | 146 | 213248 | 15394 | 64269944 |
Hyperbilirubinaemia | 57.71 | 13.32 | 3 | 213391 | 21202 | 64264136 |
Arrhythmia | 57.66 | 13.32 | 54 | 213340 | 52890 | 64232448 |
Septic shock | 57.44 | 13.32 | 169 | 213225 | 105268 | 64180070 |
Flushing | 57.29 | 13.32 | 108 | 213286 | 78540 | 64206798 |
Cardiac disorder | 57.25 | 13.32 | 60 | 213334 | 55756 | 64229582 |
X-ray abnormal | 57.12 | 13.32 | 44 | 213350 | 1451 | 64283887 |
Blood sodium decreased | 56.38 | 13.32 | 14 | 213380 | 29468 | 64255870 |
Withdrawal syndrome | 56.37 | 13.32 | 6 | 213388 | 23486 | 64261852 |
Cholestasis | 56.03 | 13.32 | 40 | 213354 | 44832 | 64240506 |
Axial spondyloarthritis | 55.24 | 13.32 | 27 | 213367 | 381 | 64284957 |
Rheumatoid factor negative | 55.00 | 13.32 | 38 | 213356 | 1055 | 64284283 |
Chills | 54.41 | 13.32 | 251 | 213143 | 137013 | 64148325 |
Status epilepticus | 53.37 | 13.32 | 5 | 213389 | 21658 | 64263680 |
Cerebral infarction | 53.37 | 13.32 | 35 | 213359 | 41009 | 64244329 |
Product administration error | 53.11 | 13.32 | 13 | 213381 | 27630 | 64257708 |
Onychomadesis | 52.65 | 13.32 | 56 | 213338 | 2828 | 64282510 |
Ventricular fibrillation | 52.64 | 13.32 | 8 | 213386 | 23852 | 64261486 |
Pulmonary fibrosis | 52.51 | 13.32 | 217 | 213177 | 29661 | 64255677 |
Blood magnesium increased | 52.48 | 13.32 | 59 | 213335 | 3172 | 64282166 |
Angioedema | 52.35 | 13.32 | 77 | 213317 | 61744 | 64223594 |
Posterior reversible encephalopathy syndrome | 52.24 | 13.32 | 7 | 213387 | 22939 | 64262399 |
Cytomegalovirus infection | 52.18 | 13.32 | 29 | 213365 | 37170 | 64248168 |
Labelled drug-drug interaction medication error | 52.01 | 13.32 | 6 | 213388 | 22056 | 64263282 |
Pallor | 51.89 | 13.32 | 32 | 213362 | 38749 | 64246589 |
Extremity contracture | 51.79 | 13.32 | 43 | 213351 | 1582 | 64283756 |
Jaundice | 51.06 | 13.32 | 51 | 213343 | 48461 | 64236877 |
Synovial fluid analysis | 51.01 | 13.32 | 42 | 213352 | 1527 | 64283811 |
Interstitial lung disease | 50.97 | 13.32 | 521 | 212873 | 97211 | 64188127 |
Tenosynovitis stenosans | 50.61 | 13.32 | 46 | 213348 | 1914 | 64283424 |
Therapy cessation | 50.61 | 13.32 | 22 | 213372 | 32467 | 64252871 |
Dystonia | 50.32 | 13.32 | 3 | 213391 | 18862 | 64266476 |
Electrolyte imbalance | 50.23 | 13.32 | 11 | 213383 | 25232 | 64260106 |
Right ventricular failure | 50.22 | 13.32 | 6 | 213388 | 21465 | 64263873 |
Retinitis | 50.09 | 13.32 | 47 | 213347 | 2038 | 64283300 |
Tachypnoea | 50.08 | 13.32 | 13 | 213381 | 26558 | 64258780 |
Hemiparesis | 50.07 | 13.32 | 18 | 213376 | 29809 | 64255529 |
Uveitis | 50.03 | 13.32 | 122 | 213272 | 12586 | 64272752 |
Hallucination, visual | 49.88 | 13.32 | 15 | 213379 | 27819 | 64257519 |
Bone density decreased | 49.71 | 13.32 | 105 | 213289 | 9847 | 64275491 |
Extrapyramidal disorder | 49.56 | 13.32 | 4 | 213390 | 19548 | 64265790 |
Rectal haemorrhage | 49.47 | 13.32 | 80 | 213314 | 61737 | 64223601 |
Tumour lysis syndrome | 49.22 | 13.32 | 4 | 213390 | 19436 | 64265902 |
Respiratory depression | 49.19 | 13.32 | 9 | 213385 | 23434 | 64261904 |
Poisoning | 49.04 | 13.32 | 7 | 213387 | 21872 | 64263466 |
Neuropathy peripheral | 48.92 | 13.32 | 211 | 213183 | 117314 | 64168024 |
Osteoporosis | 48.76 | 13.32 | 271 | 213123 | 41809 | 64243529 |
Diabetic ketoacidosis | 48.44 | 13.32 | 19 | 213375 | 29826 | 64255512 |
Pulmonary congestion | 48.35 | 13.32 | 10 | 213384 | 23870 | 64261468 |
Presyncope | 48.29 | 13.32 | 28 | 213366 | 35061 | 64250277 |
Hepatocellular injury | 48.25 | 13.32 | 47 | 213347 | 45188 | 64240150 |
Hyperthyroidism | 48.16 | 13.32 | 3 | 213391 | 18176 | 64267162 |
Dermatitis allergic | 48.14 | 13.32 | 134 | 213260 | 14975 | 64270363 |
Blood alkaline phosphatase increased | 47.75 | 13.32 | 70 | 213324 | 56209 | 64229129 |
Circulatory collapse | 47.74 | 13.32 | 26 | 213368 | 33706 | 64251632 |
Multiple allergies | 47.67 | 13.32 | 76 | 213318 | 5738 | 64279600 |
Coagulopathy | 47.57 | 13.32 | 23 | 213371 | 31897 | 64253441 |
Cough | 47.27 | 13.32 | 709 | 212685 | 301439 | 63983899 |
Tuberculosis | 46.95 | 13.32 | 121 | 213273 | 12917 | 64272421 |
Diplopia | 46.93 | 13.32 | 15 | 213379 | 26750 | 64258588 |
Full blood count decreased | 46.68 | 13.32 | 9 | 213385 | 22573 | 64262765 |
Neck mass | 46.46 | 13.32 | 62 | 213332 | 3982 | 64281356 |
Hepatic function abnormal | 46.24 | 13.32 | 89 | 213305 | 64224 | 64221114 |
Scleritis | 46.21 | 13.32 | 53 | 213341 | 2913 | 64282425 |
Myelodysplastic syndrome | 45.69 | 13.32 | 17 | 213377 | 27562 | 64257776 |
Depressed mood | 45.64 | 13.32 | 41 | 213353 | 40971 | 64244367 |
Torsade de pointes | 45.60 | 13.32 | 3 | 213391 | 17360 | 64267978 |
Acute myeloid leukaemia | 45.38 | 13.32 | 17 | 213377 | 27446 | 64257892 |
Hypothermia | 45.34 | 13.32 | 6 | 213388 | 19850 | 64265488 |
Drug dependence | 45.25 | 13.32 | 27 | 213367 | 33285 | 64252053 |
Emotional distress | 45.16 | 13.32 | 32 | 213362 | 36006 | 64249332 |
Haemodialysis | 44.70 | 13.32 | 3 | 213391 | 17074 | 64268264 |
Lyme disease | 44.28 | 13.32 | 47 | 213347 | 2368 | 64282970 |
Blood pressure fluctuation | 43.79 | 13.32 | 308 | 213086 | 51563 | 64233775 |
Angina pectoris | 43.44 | 13.32 | 51 | 213343 | 45030 | 64240308 |
Pustular psoriasis | 43.33 | 13.32 | 61 | 213333 | 4122 | 64281216 |
Ataxia | 43.19 | 13.32 | 10 | 213384 | 22074 | 64263264 |
Tuberculin test positive | 43.11 | 13.32 | 52 | 213342 | 3016 | 64282322 |
Breast cancer | 43.08 | 13.32 | 201 | 213193 | 28947 | 64256391 |
Lower limb fracture | 43.02 | 13.32 | 120 | 213274 | 13425 | 64271913 |
Foot fracture | 42.86 | 13.32 | 145 | 213249 | 18012 | 64267326 |
Dry eye | 42.81 | 13.32 | 200 | 213194 | 28819 | 64256519 |
Muscle twitching | 42.77 | 13.32 | 6 | 213388 | 18992 | 64266346 |
Blood glucose decreased | 42.28 | 13.32 | 12 | 213382 | 23111 | 64262227 |
Bacteraemia | 42.27 | 13.32 | 18 | 213376 | 26893 | 64258445 |
Delirium | 42.12 | 13.32 | 105 | 213289 | 69089 | 64216249 |
Dry skin | 42.08 | 13.32 | 65 | 213329 | 51096 | 64234242 |
Hyperlipidaemia | 41.87 | 13.32 | 12 | 213382 | 22964 | 64262374 |
Liver function test abnormal | 41.85 | 13.32 | 338 | 213056 | 59063 | 64226275 |
Synovial cyst | 41.65 | 13.32 | 84 | 213310 | 7623 | 64277715 |
Atrial flutter | 41.62 | 13.32 | 7 | 213387 | 19373 | 64265965 |
Sudden death | 41.56 | 13.32 | 8 | 213386 | 20088 | 64265250 |
Left ventricular dysfunction | 41.54 | 13.32 | 4 | 213390 | 16950 | 64268388 |
Carpal tunnel syndrome | 41.50 | 13.32 | 131 | 213263 | 15697 | 64269641 |
Joint injury | 41.38 | 13.32 | 168 | 213226 | 22779 | 64262559 |
Device related infection | 41.35 | 13.32 | 25 | 213369 | 30601 | 64254737 |
Visual acuity reduced | 41.30 | 13.32 | 19 | 213375 | 27122 | 64258216 |
Vascular access complication | 41.26 | 13.32 | 32 | 213362 | 1066 | 64284272 |
Shock haemorrhagic | 41.04 | 13.32 | 4 | 213390 | 16787 | 64268551 |
Device issue | 40.96 | 13.32 | 12 | 213382 | 22636 | 64262702 |
Acute respiratory distress syndrome | 40.90 | 13.32 | 41 | 213353 | 38894 | 64246444 |
Bone cyst | 40.71 | 13.32 | 43 | 213351 | 2154 | 64283184 |
Speech disorder | 40.37 | 13.32 | 61 | 213333 | 48380 | 64236958 |
Ileus | 40.04 | 13.32 | 13 | 213381 | 22953 | 64262385 |
Maternal exposure timing unspecified | 39.88 | 13.32 | 47 | 213347 | 2660 | 64282678 |
Product prescribing error | 39.56 | 13.32 | 35 | 213359 | 35234 | 64250104 |
Weight decreased | 39.53 | 13.32 | 686 | 212708 | 285053 | 64000285 |
Bursitis | 39.30 | 13.32 | 158 | 213236 | 21327 | 64264011 |
Red cell distribution width decreased | 39.22 | 13.32 | 31 | 213363 | 1062 | 64284276 |
Therapy non-responder | 39.11 | 13.32 | 361 | 213033 | 65538 | 64219800 |
Aspiration | 38.80 | 13.32 | 5 | 213389 | 16880 | 64268458 |
Head injury | 38.79 | 13.32 | 31 | 213363 | 32811 | 64252527 |
Memory impairment | 38.69 | 13.32 | 149 | 213245 | 85533 | 64199805 |
Mitral valve incompetence | 38.67 | 13.32 | 18 | 213376 | 25520 | 64259818 |
Gamma-glutamyltransferase increased | 38.60 | 13.32 | 63 | 213331 | 48447 | 64236891 |
Gastrooesophageal reflux disease | 38.57 | 13.32 | 143 | 213251 | 83000 | 64202338 |
Cytology abnormal | 38.41 | 13.32 | 20 | 213374 | 325 | 64285013 |
Pericardial effusion | 38.27 | 13.32 | 44 | 213350 | 39210 | 64246128 |
Pancreatitis | 38.23 | 13.32 | 88 | 213306 | 59519 | 64225819 |
Cyanosis | 37.82 | 13.32 | 13 | 213381 | 22142 | 64263196 |
Bedridden | 37.63 | 13.32 | 95 | 213299 | 10014 | 64275324 |
Brain oedema | 37.61 | 13.32 | 13 | 213381 | 22062 | 64263276 |
Transfusion | 37.56 | 13.32 | 7 | 213387 | 17987 | 64267351 |
Deafness neurosensory | 37.51 | 13.32 | 72 | 213322 | 6302 | 64279036 |
Staphylococcal infection | 37.43 | 13.32 | 69 | 213325 | 50609 | 64234729 |
Nervousness | 37.36 | 13.32 | 26 | 213368 | 29530 | 64255808 |
Cardiac failure acute | 37.18 | 13.32 | 5 | 213389 | 16339 | 64268999 |
Mental impairment | 37.17 | 13.32 | 5 | 213389 | 16338 | 64269000 |
Hypovolaemia | 37.04 | 13.32 | 4 | 213390 | 15482 | 64269856 |
Device dislocation | 36.90 | 13.32 | 12 | 213382 | 21166 | 64264172 |
Malnutrition | 36.73 | 13.32 | 9 | 213385 | 19116 | 64266222 |
Mydriasis | 36.51 | 13.32 | 4 | 213390 | 15308 | 64270030 |
Skin exfoliation | 35.99 | 13.32 | 58 | 213336 | 44827 | 64240511 |
Product use in unapproved indication | 35.93 | 13.32 | 392 | 213002 | 176226 | 64109112 |
Mean platelet volume decreased | 35.91 | 13.32 | 36 | 213358 | 1695 | 64283643 |
Myocardial ischaemia | 35.81 | 13.32 | 16 | 213378 | 23235 | 64262103 |
Thrombotic microangiopathy | 35.80 | 13.32 | 6 | 213388 | 16649 | 64268689 |
Complication associated with device | 35.80 | 13.32 | 4 | 213390 | 15076 | 64270262 |
Acute hepatic failure | 35.70 | 13.32 | 21 | 213373 | 26091 | 64259247 |
C-reactive protein | 35.61 | 13.32 | 28 | 213366 | 952 | 64284386 |
Delusion | 35.54 | 13.32 | 8 | 213386 | 18006 | 64267332 |
Lupus-like syndrome | 35.25 | 13.32 | 85 | 213309 | 8706 | 64276632 |
Herpes zoster | 35.21 | 13.32 | 409 | 212985 | 78778 | 64206560 |
Drug tolerance | 34.91 | 13.32 | 68 | 213326 | 6017 | 64279321 |
Asthma | 34.90 | 13.32 | 179 | 213215 | 95046 | 64190292 |
Metastases to bone | 34.87 | 13.32 | 12 | 213382 | 20423 | 64264915 |
Neutrophil count increased | 34.77 | 13.32 | 20 | 213374 | 25154 | 64260184 |
Pregnancy | 34.68 | 13.32 | 149 | 213245 | 20716 | 64264622 |
Joint arthroplasty | 34.42 | 13.32 | 38 | 213356 | 2002 | 64283336 |
Peritonitis | 34.39 | 13.32 | 20 | 213374 | 25003 | 64260335 |
Nephropathy toxic | 34.11 | 13.32 | 8 | 213386 | 17506 | 64267832 |
Bone pain | 34.05 | 13.32 | 66 | 213328 | 47506 | 64237832 |
Hip fracture | 34.04 | 13.32 | 24 | 213370 | 27075 | 64258263 |
Diabetes mellitus inadequate control | 33.91 | 13.32 | 14 | 213380 | 21307 | 64264031 |
Drug ineffective for unapproved indication | 33.61 | 13.32 | 32 | 213362 | 31101 | 64254237 |
Arteriosclerosis | 33.52 | 13.32 | 6 | 213388 | 15871 | 64269467 |
Lymphoma | 33.50 | 13.32 | 112 | 213282 | 13829 | 64271509 |
Colitis | 33.45 | 13.32 | 92 | 213302 | 58582 | 64226756 |
Colitis ulcerative | 33.45 | 13.32 | 158 | 213236 | 22870 | 64262468 |
Inappropriate antidiuretic hormone secretion | 33.30 | 13.32 | 16 | 213378 | 22273 | 64263065 |
Hepatic encephalopathy | 33.23 | 13.32 | 14 | 213380 | 21052 | 64264286 |
Cellulitis | 33.23 | 13.32 | 178 | 213216 | 93479 | 64191859 |
Ankle arthroplasty | 33.17 | 13.32 | 26 | 213368 | 880 | 64284458 |
Coordination abnormal | 33.05 | 13.32 | 5 | 213389 | 14959 | 64270379 |
Precancerous cells present | 32.97 | 13.32 | 27 | 213367 | 974 | 64284364 |
Subarachnoid haemorrhage | 32.93 | 13.32 | 10 | 213384 | 18428 | 64266910 |
Myositis | 32.86 | 13.32 | 7 | 213387 | 16370 | 64268968 |
Toxic epidermal necrolysis | 32.74 | 13.32 | 45 | 213349 | 37121 | 64248217 |
Tricuspid valve incompetence | 32.66 | 13.32 | 8 | 213386 | 16995 | 64268343 |
Throat irritation | 32.61 | 13.32 | 36 | 213358 | 32675 | 64252663 |
Throat tightness | 32.56 | 13.32 | 18 | 213376 | 23142 | 64262196 |
Arteriosclerosis coronary artery | 32.50 | 13.32 | 6 | 213388 | 15523 | 64269815 |
Pulmonary haemorrhage | 32.36 | 13.32 | 3 | 213391 | 13106 | 64272232 |
Hypophosphataemia | 32.32 | 13.32 | 5 | 213389 | 14715 | 64270623 |
Ventricular extrasystoles | 32.23 | 13.32 | 9 | 213385 | 17520 | 64267818 |
Pollakiuria | 32.21 | 13.32 | 34 | 213360 | 31496 | 64253842 |
Blood loss anaemia | 32.20 | 13.32 | 4 | 213390 | 13888 | 64271450 |
Small intestinal obstruction | 32.17 | 13.32 | 19 | 213375 | 23554 | 64261784 |
Swollen tongue | 32.14 | 13.32 | 41 | 213353 | 34913 | 64250425 |
Enterococcal infection | 32.12 | 13.32 | 4 | 213390 | 13862 | 64271476 |
Shoulder arthroplasty | 31.84 | 13.32 | 42 | 213352 | 2667 | 64282671 |
Eosinophilia | 31.68 | 13.32 | 48 | 213346 | 38028 | 64247310 |
Activated partial thromboplastin time prolonged | 31.51 | 13.32 | 3 | 213391 | 12828 | 64272510 |
Live birth | 31.48 | 13.32 | 95 | 213299 | 11109 | 64274229 |
Myelosuppression | 31.42 | 13.32 | 20 | 213374 | 23810 | 64261528 |
Smear cervix abnormal | 31.35 | 13.32 | 39 | 213355 | 2335 | 64283003 |
Cartilage atrophy | 31.33 | 13.32 | 14 | 213380 | 159 | 64285179 |
Mental disorder | 31.19 | 13.32 | 25 | 213369 | 26420 | 64258918 |
Acidosis | 31.15 | 13.32 | 10 | 213384 | 17785 | 64267553 |
Prothrombin time prolonged | 31.04 | 13.32 | 7 | 213387 | 15734 | 64269604 |
Epigastric discomfort | 30.76 | 13.32 | 69 | 213325 | 6742 | 64278596 |
Supraventricular tachycardia | 30.75 | 13.32 | 12 | 213382 | 18895 | 64266443 |
Dialysis | 30.54 | 13.32 | 9 | 213385 | 16911 | 64268427 |
Full blood count abnormal | 30.50 | 13.32 | 32 | 213362 | 29725 | 64255613 |
Klebsiella infection | 30.36 | 13.32 | 4 | 213390 | 13277 | 64272061 |
Therapeutic product effect variable | 30.15 | 13.32 | 32 | 213362 | 1612 | 64283726 |
Pulmonary tuberculosis | 30.08 | 13.32 | 71 | 213323 | 7173 | 64278165 |
Lower gastrointestinal haemorrhage | 30.01 | 13.32 | 5 | 213389 | 13934 | 64271404 |
Suicidal ideation | 29.85 | 13.32 | 116 | 213278 | 66426 | 64218912 |
Accidental exposure to product | 29.76 | 13.32 | 26 | 213368 | 26338 | 64259000 |
Vertigo | 29.71 | 13.32 | 98 | 213296 | 58913 | 64226425 |
Retching | 29.65 | 13.32 | 7 | 213387 | 15249 | 64270089 |
Flatulence | 29.63 | 13.32 | 45 | 213349 | 35621 | 64249717 |
Mass excision | 29.63 | 13.32 | 16 | 213378 | 281 | 64285057 |
Hypernatraemia | 29.54 | 13.32 | 3 | 213391 | 12186 | 64273152 |
Juvenile idiopathic arthritis | 29.48 | 13.32 | 49 | 213345 | 3830 | 64281508 |
Lacrimation increased | 29.25 | 13.32 | 12 | 213382 | 18334 | 64267004 |
Oral discomfort | 29.23 | 13.32 | 77 | 213317 | 8329 | 64277009 |
Elbow deformity | 29.18 | 13.32 | 28 | 213366 | 1249 | 64284089 |
Oxygen saturation decreased | 29.14 | 13.32 | 221 | 213173 | 106955 | 64178383 |
Off label use | 29.04 | 13.32 | 2450 | 210944 | 630356 | 63654982 |
Vaginal haemorrhage | 28.73 | 13.32 | 14 | 213380 | 19330 | 64266008 |
Cholelithiasis | 28.52 | 13.32 | 68 | 213326 | 45438 | 64239900 |
Rash pruritic | 28.49 | 13.32 | 303 | 213091 | 57101 | 64228237 |
Tinnitus | 28.42 | 13.32 | 43 | 213351 | 34090 | 64251248 |
Stress | 28.42 | 13.32 | 316 | 213078 | 60218 | 64225120 |
Decubitus ulcer | 28.36 | 13.32 | 5 | 213389 | 13374 | 64271964 |
Angina unstable | 28.33 | 13.32 | 8 | 213386 | 15459 | 64269879 |
Osteosclerosis | 27.80 | 13.32 | 45 | 213349 | 3441 | 64281897 |
Blood magnesium decreased | 27.79 | 13.32 | 6 | 213388 | 13899 | 64271439 |
Wound infection | 27.74 | 13.32 | 110 | 213284 | 14754 | 64270584 |
Blood pressure systolic abnormal | 27.65 | 13.32 | 84 | 213310 | 9858 | 64275480 |
Anal incontinence | 27.58 | 13.32 | 8 | 213386 | 15188 | 64270150 |
Second primary malignancy | 27.53 | 13.32 | 4 | 213390 | 12333 | 64273005 |
Blood triglycerides increased | 27.50 | 13.32 | 14 | 213380 | 18852 | 64266486 |
Leukocytosis | 27.33 | 13.32 | 52 | 213342 | 37688 | 64247650 |
Spinal meningioma benign | 27.25 | 13.32 | 11 | 213383 | 95 | 64285243 |
Paranoia | 27.22 | 13.32 | 10 | 213384 | 16342 | 64268996 |
Renal tubular necrosis | 27.22 | 13.32 | 20 | 213374 | 22090 | 64263248 |
Nightmare | 27.16 | 13.32 | 18 | 213376 | 20975 | 64264363 |
Chromaturia | 27.14 | 13.32 | 21 | 213373 | 22590 | 64262748 |
Joint space narrowing | 27.08 | 13.32 | 14 | 213380 | 224 | 64285114 |
Mania | 27.05 | 13.32 | 10 | 213384 | 16276 | 64269062 |
Hepatitis cholestatic | 26.99 | 13.32 | 4 | 213390 | 12151 | 64273187 |
Rheumatoid lung | 26.95 | 13.32 | 37 | 213357 | 2442 | 64282896 |
Haemodynamic instability | 26.79 | 13.32 | 8 | 213386 | 14904 | 64270434 |
Lip swelling | 26.76 | 13.32 | 40 | 213354 | 31867 | 64253471 |
Hypersomnia | 26.75 | 13.32 | 16 | 213378 | 19701 | 64265637 |
Hepatitis | 26.69 | 13.32 | 249 | 213145 | 45333 | 64240005 |
Cyst | 26.61 | 13.32 | 94 | 213300 | 11933 | 64273405 |
Hemiplegia | 26.58 | 13.32 | 5 | 213389 | 12763 | 64272575 |
Hypotonia | 26.55 | 13.32 | 3 | 213391 | 11209 | 64274129 |
Anaphylactic shock | 26.44 | 13.32 | 37 | 213357 | 30291 | 64255047 |
Renal injury | 26.43 | 13.32 | 9 | 213385 | 15420 | 64269918 |
Nocturia | 26.41 | 13.32 | 3 | 213391 | 11162 | 64274176 |
Limb discomfort | 26.33 | 13.32 | 167 | 213227 | 27008 | 64258330 |
Acute generalised exanthematous pustulosis | 26.26 | 13.32 | 7 | 213387 | 14051 | 64271287 |
Polyuria | 26.21 | 13.32 | 5 | 213389 | 12638 | 64272700 |
Osteonecrosis | 26.07 | 13.32 | 33 | 213361 | 28196 | 64257142 |
Oesophagitis | 26.07 | 13.32 | 20 | 213374 | 21610 | 64263728 |
Progressive multifocal leukoencephalopathy | 25.88 | 13.32 | 14 | 213380 | 18218 | 64267120 |
Aplastic anaemia | 25.87 | 13.32 | 7 | 213387 | 13913 | 64271425 |
Lymphopenia | 25.84 | 13.32 | 28 | 213366 | 25629 | 64259709 |
Panic attack | 25.74 | 13.32 | 19 | 213375 | 20934 | 64264404 |
Dementia | 25.29 | 13.32 | 19 | 213375 | 20747 | 64264591 |
Stress at work | 25.12 | 13.32 | 23 | 213371 | 966 | 64284372 |
Tender joint count increased | 25.09 | 13.32 | 11 | 213383 | 119 | 64285219 |
Depression | 25.01 | 13.32 | 441 | 212953 | 182850 | 64102488 |
Therapy interrupted | 24.83 | 13.32 | 18 | 213376 | 20018 | 64265320 |
Cardiomegaly | 24.81 | 13.32 | 25 | 213369 | 23659 | 64261679 |
Troponin increased | 24.67 | 13.32 | 10 | 213384 | 15389 | 64269949 |
Nervous system disorder | 24.58 | 13.32 | 24 | 213370 | 23054 | 64262284 |
Incontinence | 24.58 | 13.32 | 5 | 213389 | 12076 | 64273262 |
Blood pressure diastolic abnormal | 24.55 | 13.32 | 91 | 213303 | 11826 | 64273512 |
Iritis | 24.55 | 13.32 | 40 | 213354 | 3076 | 64282262 |
Myopathy | 24.48 | 13.32 | 14 | 213380 | 17666 | 64267672 |
Mycobacterium tuberculosis complex test positive | 24.47 | 13.32 | 32 | 213362 | 2015 | 64283323 |
Injection site pain | 24.39 | 13.32 | 243 | 213151 | 111165 | 64174173 |
Acute coronary syndrome | 24.39 | 13.32 | 17 | 213377 | 19293 | 64266045 |
Liver disorder | 24.36 | 13.32 | 277 | 213117 | 53074 | 64232264 |
Clostridium difficile infection | 24.33 | 13.32 | 52 | 213342 | 36111 | 64249227 |
Adjustment disorder with depressed mood | 24.23 | 13.32 | 35 | 213359 | 2422 | 64282916 |
Obesity | 24.20 | 13.32 | 133 | 213261 | 20429 | 64264909 |
Demyelination | 24.17 | 13.32 | 63 | 213331 | 6771 | 64278567 |
Apnoea | 24.16 | 13.32 | 3 | 213391 | 10419 | 64274919 |
Aspergillus infection | 24.10 | 13.32 | 12 | 213382 | 16367 | 64268971 |
Schizophrenia | 24.06 | 13.32 | 4 | 213390 | 11164 | 64274174 |
Hallucination, auditory | 24.05 | 13.32 | 13 | 213381 | 16926 | 64268412 |
Disseminated intravascular coagulation | 23.92 | 13.32 | 44 | 213350 | 32304 | 64253034 |
Central nervous system lesion | 23.91 | 13.32 | 5 | 213389 | 11844 | 64273494 |
Sensory disturbance | 23.88 | 13.32 | 7 | 213387 | 13201 | 64272137 |
Cushingoid | 23.80 | 13.32 | 67 | 213327 | 7536 | 64277802 |
Multiple fractures | 23.79 | 13.32 | 58 | 213336 | 5982 | 64279356 |
Rash maculo-papular | 23.74 | 13.32 | 78 | 213316 | 46948 | 64238390 |
Immune reconstitution inflammatory syndrome | 23.69 | 13.32 | 6 | 213388 | 12464 | 64272874 |
Anovulatory cycle | 23.59 | 13.32 | 10 | 213384 | 99 | 64285239 |
Pseudomonas infection | 23.59 | 13.32 | 15 | 213379 | 17868 | 64267470 |
Arthritis bacterial | 23.49 | 13.32 | 68 | 213326 | 7771 | 64277567 |
Hyperthermia | 23.48 | 13.32 | 11 | 213383 | 15539 | 64269799 |
Spondyloarthropathy | 23.40 | 13.32 | 20 | 213374 | 766 | 64284572 |
Lymphoproliferative disorder | 23.38 | 13.32 | 52 | 213342 | 5051 | 64280287 |
Blindness | 23.34 | 13.32 | 23 | 213371 | 21996 | 64263342 |
Joint dislocation | 23.16 | 13.32 | 87 | 213307 | 11378 | 64273960 |
Cardiomyopathy | 23.05 | 13.32 | 30 | 213364 | 25326 | 64260012 |
Thyroid disorder | 23.02 | 13.32 | 88 | 213306 | 11604 | 64273734 |
COVID-19 pneumonia | 22.95 | 13.32 | 13 | 213381 | 16491 | 64268847 |
Atrioventricular block first degree | 22.78 | 13.32 | 4 | 213390 | 10730 | 64274608 |
Neck pain | 22.72 | 13.32 | 307 | 213087 | 61226 | 64224112 |
Sleep apnoea syndrome | 22.58 | 13.32 | 40 | 213354 | 29792 | 64255546 |
Bronchospasm | 22.58 | 13.32 | 23 | 213371 | 21659 | 64263679 |
Anger | 22.47 | 13.32 | 12 | 213382 | 15729 | 64269609 |
Mononucleosis syndrome | 22.42 | 13.32 | 10 | 213384 | 113 | 64285225 |
Eyelid exfoliation | 22.42 | 13.32 | 10 | 213384 | 113 | 64285225 |
Atrioventricular block | 22.41 | 13.32 | 6 | 213388 | 12009 | 64273329 |
Incorrect dose administered | 22.39 | 13.32 | 114 | 213280 | 60651 | 64224687 |
Erectile dysfunction | 22.27 | 13.32 | 7 | 213387 | 12620 | 64272718 |
Psychomotor hyperactivity | 22.17 | 13.32 | 10 | 213384 | 14441 | 64270897 |
Xyphoid retraction | 22.09 | 13.32 | 11 | 213383 | 162 | 64285176 |
Hypertriglyceridaemia | 22.06 | 13.32 | 5 | 213389 | 11200 | 64274138 |
Lipase increased | 22.04 | 13.32 | 10 | 213384 | 14392 | 64270946 |
Inflammatory pain | 21.93 | 13.32 | 20 | 213374 | 836 | 64284502 |
Weber tuning fork test abnormal | 21.88 | 13.32 | 9 | 213385 | 82 | 64285256 |
Haematochezia | 21.46 | 13.32 | 130 | 213264 | 66243 | 64219095 |
Bundle branch block right | 21.42 | 13.32 | 4 | 213390 | 10265 | 64275073 |
Bronchopulmonary aspergillosis | 21.33 | 13.32 | 19 | 213375 | 19066 | 64266272 |
Bladder transitional cell carcinoma | 21.26 | 13.32 | 32 | 213362 | 2298 | 64283040 |
Electrocardiogram abnormal | 21.20 | 13.32 | 9 | 213385 | 13472 | 64271866 |
Mean cell volume decreased | 21.12 | 13.32 | 40 | 213354 | 3466 | 64281872 |
Urticarial vasculitis | 21.11 | 13.32 | 15 | 213379 | 436 | 64284902 |
Blood lactate dehydrogenase increased | 21.07 | 13.32 | 49 | 213345 | 33029 | 64252309 |
Mucosal inflammation | 21.07 | 13.32 | 121 | 213273 | 62463 | 64222875 |
White blood cell count increased | 20.98 | 13.32 | 130 | 213264 | 65884 | 64219454 |
Adenoiditis | 20.91 | 13.32 | 7 | 213387 | 33 | 64285305 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 20.88 | 13.32 | 36 | 213358 | 2900 | 64282438 |
Faeces discoloured | 20.86 | 13.32 | 33 | 213361 | 25696 | 64259642 |
Effusion | 20.83 | 13.32 | 29 | 213365 | 1939 | 64283399 |
Stevens-Johnson syndrome | 20.82 | 13.32 | 52 | 213342 | 34197 | 64251141 |
Metastases to central nervous system | 20.76 | 13.32 | 10 | 213384 | 13902 | 64271436 |
Antinuclear antibody positive | 20.47 | 13.32 | 56 | 213338 | 6194 | 64279144 |
Polyglandular disorder | 20.41 | 13.32 | 7 | 213387 | 36 | 64285302 |
Palpitations | 20.41 | 13.32 | 234 | 213160 | 104254 | 64181084 |
Restless legs syndrome | 20.41 | 13.32 | 16 | 213378 | 17100 | 64268238 |
Rotator cuff repair | 20.40 | 13.32 | 25 | 213369 | 1474 | 64283864 |
Device occlusion | 20.38 | 13.32 | 4 | 213390 | 9909 | 64275429 |
Crepitations | 20.28 | 13.32 | 65 | 213329 | 7850 | 64277488 |
Mycobacterium marinum infection | 20.25 | 13.32 | 14 | 213380 | 389 | 64284949 |
Impaired quality of life | 20.23 | 13.32 | 57 | 213337 | 6414 | 64278924 |
Device difficult to use | 20.05 | 13.32 | 4 | 213390 | 9794 | 64275544 |
Peritonitis bacterial | 20.02 | 13.32 | 3 | 213391 | 9040 | 64276298 |
Faecaloma | 19.85 | 13.32 | 4 | 213390 | 9724 | 64275614 |
Gout | 19.81 | 13.32 | 25 | 213369 | 21388 | 64263950 |
Iron deficiency anaemia | 19.79 | 13.32 | 26 | 213368 | 21863 | 64263475 |
Product substitution issue | 19.70 | 13.32 | 18 | 213376 | 17843 | 64267495 |
Escherichia infection | 19.63 | 13.32 | 13 | 213381 | 15155 | 64270183 |
Congestive cardiomyopathy | 19.61 | 13.32 | 5 | 213389 | 10339 | 64274999 |
Pneumonia fungal | 19.53 | 13.32 | 3 | 213391 | 8874 | 64276464 |
Tubulointerstitial nephritis | 19.52 | 13.32 | 46 | 213348 | 30863 | 64254475 |
Paralysis | 19.46 | 13.32 | 7 | 213387 | 11588 | 64273750 |
Upper respiratory tract infection | 19.35 | 13.32 | 151 | 213243 | 72634 | 64212704 |
Intestinal ischaemia | 19.33 | 13.32 | 7 | 213387 | 11542 | 64273796 |
Walking aid user | 19.32 | 13.32 | 55 | 213339 | 6226 | 64279112 |
Foot operation | 19.23 | 13.32 | 43 | 213351 | 4192 | 64281146 |
Hyperuricaemia | 19.18 | 13.32 | 5 | 213389 | 10186 | 64275152 |
Premature delivery | 19.04 | 13.32 | 20 | 213374 | 18569 | 64266769 |
Colitis microscopic | 19.02 | 13.32 | 61 | 213333 | 7371 | 64277967 |
Glomerular filtration rate decreased | 19.01 | 13.32 | 22 | 213372 | 19550 | 64265788 |
Urine output decreased | 18.94 | 13.32 | 16 | 213378 | 16476 | 64268862 |
Gingival bleeding | 18.86 | 13.32 | 13 | 213381 | 14841 | 64270497 |
Cold sweat | 18.85 | 13.32 | 16 | 213378 | 16439 | 64268899 |
Extrapulmonary tuberculosis | 18.72 | 13.32 | 13 | 213381 | 364 | 64284974 |
Abdominal pain lower | 18.70 | 13.32 | 37 | 213357 | 26432 | 64258906 |
Lung infiltration | 18.70 | 13.32 | 25 | 213369 | 20864 | 64264474 |
Personality change | 18.69 | 13.32 | 3 | 213391 | 8590 | 64276748 |
Rash erythematous | 18.63 | 13.32 | 90 | 213304 | 48543 | 64236795 |
Injection site reaction | 18.55 | 13.32 | 236 | 213158 | 46428 | 64238910 |
Metastases to lung | 18.54 | 13.32 | 14 | 213380 | 15250 | 64270088 |
Cerebral ischaemia | 18.53 | 13.32 | 5 | 213389 | 9957 | 64275381 |
Skin burning sensation | 18.43 | 13.32 | 6 | 213388 | 10577 | 64274761 |
Bacterial infection | 18.39 | 13.32 | 34 | 213360 | 24916 | 64260422 |
Human anti-human antibody test | 18.38 | 13.32 | 13 | 213381 | 375 | 64284963 |
Heparin-induced thrombocytopenia | 18.35 | 13.32 | 3 | 213391 | 8476 | 64276862 |
Injection site erythema | 18.31 | 13.32 | 148 | 213246 | 70652 | 64214686 |
Ecchymosis | 18.17 | 13.32 | 12 | 213382 | 14010 | 64271328 |
Ureterocele | 18.11 | 13.32 | 5 | 213389 | 10 | 64285328 |
Colitis ischaemic | 18.04 | 13.32 | 11 | 213383 | 13403 | 64271935 |
Hypocalcaemia | 17.96 | 13.32 | 74 | 213320 | 41679 | 64243659 |
Insomnia | 17.84 | 13.32 | 508 | 212886 | 197328 | 64088010 |
Photosensitivity reaction | 17.80 | 13.32 | 112 | 213282 | 18061 | 64267277 |
Pulseless electrical activity | 17.76 | 13.32 | 10 | 213384 | 12729 | 64272609 |
Dermatitis contact | 17.75 | 13.32 | 4 | 213390 | 8996 | 64276342 |
Device leakage | 17.72 | 13.32 | 3 | 213391 | 8263 | 64277075 |
Feeling cold | 17.69 | 13.32 | 32 | 213362 | 23646 | 64261692 |
Sacroiliitis | 17.69 | 13.32 | 34 | 213360 | 2978 | 64282360 |
Spinal fusion surgery | 17.63 | 13.32 | 38 | 213356 | 3613 | 64281725 |
Oral lichen planus | 17.62 | 13.32 | 16 | 213378 | 665 | 64284673 |
Polyneuropathy | 17.61 | 13.32 | 24 | 213370 | 19870 | 64265468 |
Pulse absent | 17.59 | 13.32 | 4 | 213390 | 8942 | 64276396 |
Hypovolaemic shock | 17.57 | 13.32 | 6 | 213388 | 10260 | 64275078 |
Ganglioneuroma | 17.52 | 13.32 | 9 | 213385 | 142 | 64285196 |
Elbow operation | 17.51 | 13.32 | 11 | 213383 | 259 | 64285079 |
Systemic inflammatory response syndrome | 17.48 | 13.32 | 6 | 213388 | 10229 | 64275109 |
Respiratory disorder | 17.48 | 13.32 | 61 | 213333 | 36050 | 64249288 |
Gastrointestinal pain | 17.45 | 13.32 | 60 | 213334 | 7514 | 64277824 |
Gastritis | 17.43 | 13.32 | 77 | 213317 | 42541 | 64242797 |
Asphyxia | 17.42 | 13.32 | 5 | 213389 | 9561 | 64275777 |
Metabolic surgery | 17.38 | 13.32 | 18 | 213376 | 881 | 64284457 |
Ossicle disorder | 17.32 | 13.32 | 6 | 213388 | 32 | 64285306 |
Gait disturbance | 17.21 | 13.32 | 715 | 212679 | 171440 | 64113898 |
Hypertensive crisis | 17.20 | 13.32 | 21 | 213373 | 18227 | 64267111 |
Erythema multiforme | 17.11 | 13.32 | 16 | 213378 | 15685 | 64269653 |
Cholecystitis | 17.07 | 13.32 | 24 | 213370 | 19612 | 64265726 |
Appendicitis | 17.06 | 13.32 | 12 | 213382 | 13557 | 64271781 |
Prostatic specific antigen increased | 17.06 | 13.32 | 4 | 213390 | 8756 | 64276582 |
Hypoalbuminaemia | 17.02 | 13.32 | 20 | 213374 | 17654 | 64267684 |
Post procedural haemorrhage | 16.99 | 13.32 | 10 | 213384 | 12421 | 64272917 |
Abdominal tenderness | 16.98 | 13.32 | 5 | 213389 | 9400 | 64275938 |
Hot flush | 16.88 | 13.32 | 87 | 213307 | 46148 | 64239190 |
Immune thrombocytopenia | 16.84 | 13.32 | 15 | 213379 | 15051 | 64270287 |
Cystitis haemorrhagic | 16.81 | 13.32 | 3 | 213391 | 7953 | 64277385 |
Jaundice cholestatic | 16.81 | 13.32 | 4 | 213390 | 8666 | 64276672 |
Aortic bruit | 16.81 | 13.32 | 10 | 213384 | 213 | 64285125 |
Substance abuse | 16.66 | 13.32 | 5 | 213389 | 9287 | 64276051 |
Hepatic cirrhosis | 16.59 | 13.32 | 146 | 213248 | 26152 | 64259186 |
Red blood cell sedimentation rate decreased | 16.40 | 13.32 | 10 | 213384 | 223 | 64285115 |
Toxic encephalopathy | 16.34 | 13.32 | 6 | 213388 | 9809 | 64275529 |
Benign prostatic hyperplasia | 16.31 | 13.32 | 5 | 213389 | 9160 | 64276178 |
Shoulder operation | 16.24 | 13.32 | 27 | 213367 | 2111 | 64283227 |
Cardiac murmur | 16.23 | 13.32 | 9 | 213385 | 11554 | 64273784 |
Transaminases increased | 16.23 | 13.32 | 84 | 213310 | 44510 | 64240828 |
Diffuse idiopathic skeletal hyperostosis | 16.20 | 13.32 | 6 | 213388 | 40 | 64285298 |
Dizziness postural | 16.17 | 13.32 | 6 | 213388 | 9746 | 64275592 |
Pulmonary alveolar haemorrhage | 16.14 | 13.32 | 6 | 213388 | 9732 | 64275606 |
Renal mass | 16.13 | 13.32 | 31 | 213363 | 2716 | 64282622 |
Exercise tolerance decreased | 16.09 | 13.32 | 3 | 213391 | 7707 | 64277631 |
Muscle fatigue | 16.08 | 13.32 | 33 | 213361 | 3032 | 64282306 |
Investigation abnormal | 16.05 | 13.32 | 21 | 213373 | 1323 | 64284015 |
Nephropathy | 16.00 | 13.32 | 4 | 213390 | 8382 | 64276956 |
Hiccups | 15.97 | 13.32 | 4 | 213390 | 8372 | 64276966 |
Ankle fracture | 15.90 | 13.32 | 93 | 213301 | 14617 | 64270721 |
Pathogen resistance | 15.90 | 13.32 | 11 | 213383 | 12532 | 64272806 |
Device malfunction | 15.89 | 13.32 | 21 | 213373 | 17612 | 64267726 |
Bone tuberculosis | 15.87 | 13.32 | 13 | 213381 | 469 | 64284869 |
Underdose | 15.87 | 13.32 | 39 | 213355 | 25790 | 64259548 |
Brain natriuretic peptide increased | 15.86 | 13.32 | 3 | 213391 | 7630 | 64277708 |
Blood pressure increased | 15.83 | 13.32 | 442 | 212952 | 172110 | 64113228 |
Peripheral coldness | 15.82 | 13.32 | 13 | 213381 | 13571 | 64271767 |
Gastritis erosive | 15.75 | 13.32 | 6 | 213388 | 9589 | 64275749 |
Splenic embolism | 15.67 | 13.32 | 9 | 213385 | 179 | 64285159 |
Pemphigoid | 15.66 | 13.32 | 12 | 213382 | 12974 | 64272364 |
Glycosylated haemoglobin increased | 15.56 | 13.32 | 18 | 213376 | 16001 | 64269337 |
Blood urine present | 15.37 | 13.32 | 23 | 213371 | 18317 | 64267021 |
Gastric ulcer | 15.36 | 13.32 | 50 | 213344 | 30184 | 64255154 |
Respiratory rate increased | 15.35 | 13.32 | 23 | 213371 | 18308 | 64267030 |
Wound infection fungal | 15.24 | 13.32 | 9 | 213385 | 189 | 64285149 |
Hypercholesterolaemia | 15.22 | 13.32 | 95 | 213299 | 15278 | 64270060 |
Retinal haemorrhage | 15.18 | 13.32 | 3 | 213391 | 7395 | 64277943 |
Acquired claw toe | 15.18 | 13.32 | 7 | 213387 | 86 | 64285252 |
Intestinal obstruction | 15.18 | 13.32 | 65 | 213329 | 36221 | 64249117 |
Vaginal haematoma | 15.15 | 13.32 | 8 | 213386 | 134 | 64285204 |
Neuralgia | 14.96 | 13.32 | 41 | 213353 | 26143 | 64259195 |
Pulmonary toxicity | 14.90 | 13.32 | 62 | 213332 | 8499 | 64276839 |
Hiatus hernia | 14.89 | 13.32 | 27 | 213367 | 19930 | 64265408 |
Muscle spasticity | 14.87 | 13.32 | 20 | 213374 | 16649 | 64268689 |
Granuloma | 14.77 | 13.32 | 52 | 213342 | 6589 | 64278749 |
Infusion site pain | 14.73 | 13.32 | 8 | 213386 | 10389 | 64274949 |
General physical health deterioration | 14.72 | 13.32 | 822 | 212572 | 203603 | 64081735 |
Eructation | 14.67 | 13.32 | 6 | 213388 | 9185 | 64276153 |
Enterocolitis | 14.63 | 13.32 | 11 | 213383 | 12007 | 64273331 |
Orthopnoea | 14.52 | 13.32 | 6 | 213388 | 9128 | 64276210 |
Gardner-Diamond syndrome | 14.49 | 13.32 | 4 | 213390 | 8 | 64285330 |
Polychondritis | 14.49 | 13.32 | 12 | 213382 | 440 | 64284898 |
Amylase increased | 14.40 | 13.32 | 7 | 213387 | 9678 | 64275660 |
Infected varicose vein | 14.38 | 13.32 | 5 | 213389 | 27 | 64285311 |
Spinal X-ray abnormal | 14.38 | 13.32 | 5 | 213389 | 27 | 64285311 |
Rash macular | 14.37 | 13.32 | 36 | 213358 | 23649 | 64261689 |
Cholecystitis acute | 14.35 | 13.32 | 10 | 213384 | 11350 | 64273988 |
Nystagmus | 14.35 | 13.32 | 6 | 213388 | 9062 | 64276276 |
Dental caries | 14.32 | 13.32 | 9 | 213385 | 10791 | 64274547 |
Staphylococcal sepsis | 14.23 | 13.32 | 13 | 213381 | 12886 | 64272452 |
Deep vein thrombosis postoperative | 14.21 | 13.32 | 20 | 213374 | 1351 | 64283987 |
Peripheral ischaemia | 14.16 | 13.32 | 5 | 213389 | 8373 | 64276965 |
Caesarean section | 14.14 | 13.32 | 10 | 213384 | 11264 | 64274074 |
Coronary artery stenosis | 14.08 | 13.32 | 10 | 213384 | 11238 | 64274100 |
Medication error | 14.07 | 13.32 | 102 | 213292 | 49864 | 64235474 |
Nail psoriasis | 14.07 | 13.32 | 11 | 213383 | 371 | 64284967 |
Leukoencephalopathy | 13.93 | 13.32 | 3 | 213391 | 6964 | 64278374 |
Left ventricular hypertrophy | 13.93 | 13.32 | 7 | 213387 | 9499 | 64275839 |
Respiratory tract infection | 13.88 | 13.32 | 70 | 213324 | 37337 | 64248001 |
Lymphadenectomy | 13.86 | 13.32 | 17 | 213377 | 1003 | 64284335 |
Malignant polyp | 13.80 | 13.32 | 8 | 213386 | 162 | 64285176 |
Knee deformity | 13.77 | 13.32 | 16 | 213378 | 892 | 64284446 |
Sideroblastic anaemia | 13.75 | 13.32 | 9 | 213385 | 228 | 64285110 |
Brain injury | 13.64 | 13.32 | 8 | 213386 | 9957 | 64275381 |
Neurological symptom | 13.64 | 13.32 | 3 | 213391 | 6861 | 64278477 |
Macrocytosis | 13.58 | 13.32 | 27 | 213367 | 2425 | 64282913 |
Cystitis | 13.58 | 13.32 | 84 | 213310 | 42591 | 64242747 |
Mean cell haemoglobin decreased | 13.57 | 13.32 | 37 | 213357 | 4085 | 64281253 |
Enteritis | 13.52 | 13.32 | 12 | 213382 | 12065 | 64273273 |
Acute interstitial pneumonitis | 13.51 | 13.32 | 17 | 213377 | 1030 | 64284308 |
Gait inability | 13.49 | 13.32 | 206 | 213188 | 42162 | 64243176 |
International normalised ratio decreased | 13.45 | 13.32 | 4 | 213390 | 7474 | 64277864 |
Granulocytopenia | 13.44 | 13.32 | 9 | 213385 | 10431 | 64274907 |
Metastases to lymph nodes | 13.42 | 13.32 | 6 | 213388 | 8711 | 64276627 |
Eye swelling | 13.41 | 13.32 | 34 | 213360 | 22247 | 64263091 |
Haemorrhoids | 13.41 | 13.32 | 38 | 213356 | 23963 | 64261375 |
Fibrin D dimer increased | 13.35 | 13.32 | 3 | 213391 | 6762 | 64278576 |
Bone hypertrophy | 13.35 | 13.32 | 10 | 213384 | 316 | 64285022 |
Rhinitis allergic | 13.35 | 13.32 | 5 | 213389 | 8073 | 64277265 |
None
Source | Code | Description |
---|---|---|
ATC | A07EC01 | ALIMENTARY TRACT AND METABOLISM ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS INTESTINAL ANTIINFLAMMATORY AGENTS Aminosalicylic acid and similar agents |
FDA CS | M0000971 | Aminosalicylic Acids |
MeSH PA | D000700 | Analgesics |
MeSH PA | D018712 | Analgesics, Non-Narcotic |
MeSH PA | D000890 | Anti-Infective Agents |
MeSH PA | D000893 | Anti-Inflammatory Agents |
MeSH PA | D000894 | Anti-Inflammatory Agents, Non-Steroidal |
MeSH PA | D018501 | Antirheumatic Agents |
MeSH PA | D005765 | Gastrointestinal Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D018689 | Sensory System Agents |
CHEBI has role | CHEBI:35475 | non-steroidal anti-inflammatory agent |
CHEBI has role | CHEBI:35441 | antiinfective agents |
CHEBI has role | CHEBI:55324 | gastrointestinal drugs |
CHEBI has role | CHEBI:76797 | RX:glutathione R-transferase inhibitors |
CHEBI has role | CHEBI:88188 | allergenic drug |
CHEBI has role | CHEBI:173085 | ferroptosis inducers |
FDA EPC | N0000175781 | Aminosalicylate |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Ulcerative colitis | indication | 64766004 | DOID:8577 |
Rheumatoid arthritis | indication | 69896004 | DOID:7148 |
Juvenile rheumatoid arthritis | indication | 410795001 | |
Collagenous colitis | off-label use | 19311003 | DOID:0060183 |
Psoriasis with arthropathy | off-label use | 33339001 | |
Crohn's disease | off-label use | 34000006 | |
Systemic sclerosis | off-label use | 89155008 | DOID:418 |
Urinary tract obstruction | contraindication | 7163005 | DOID:5200 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Anemia due to enzyme deficiency | contraindication | 111577008 | |
Deficiency of glucose-6-phosphate dehydrogenase | contraindication | 124134002 | DOID:2862 |
Gastrointestinal obstruction | contraindication | 126765001 | |
Asthma | contraindication | 195967001 | DOID:2841 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Aplastic anemia | contraindication | 306058006 | DOID:12449 |
Porphyria | contraindication | 418470004 | |
Slow acetylator due to N-acetyltransferase enzyme variant | contraindication | 425079005 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.28 | acidic |
pKa2 | 8.93 | acidic |
pKa3 | 11.45 | acidic |
pKa4 | 1.48 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Cyclooxygenase | Enzyme | INHIBITOR | CHEMBL | CHEMBL | |||||
Arachidonate 5-lipoxygenase | Enzyme | INHIBITOR | WOMBAT-PK | CHEMBL | |||||
Carbonic anhydrase 1 | Enzyme | Ki | 5.16 | CHEMBL | |||||
Acetyl-CoA acetyltransferase, mitochondrial | Enzyme | WOMBAT-PK | |||||||
Cystine/glutamate transporter | Transporter | IC50 | 4.52 | CHEMBL | |||||
Caspase-1 | Enzyme | IC50 | 4.54 | DRUG MATRIX | |||||
Thromboxane-A synthase | Enzyme | IC50 | 4.71 | DRUG MATRIX | |||||
Interstitial collagenase | Enzyme | IC50 | 4.63 | DRUG MATRIX | |||||
Proton-coupled folate transporter | Transporter | INHIBITOR | IC50 | 4.20 | IUPHAR | ||||
Mitogen-activated protein kinase 1 | Kinase | IC50 | 5.20 | DRUG MATRIX | |||||
Sodium/bile acid cotransporter | Transporter | IC50 | 5.02 | CHEMBL | |||||
Multidrug resistance protein 1 | Transporter | EC50 | 6.04 | CHEMBL | |||||
Bifunctional purine biosynthesis protein PURH | Enzyme | Ki | 4.66 | CHEMBL | |||||
Carbonic anhydrase 2 | Enzyme | Ki | 5.06 | CHEMBL | |||||
Androgen receptor | Transcription factor | Ki | 4.53 | DRUG MATRIX | |||||
Aldose reductase | Enzyme | IC50 | 4.77 | DRUG MATRIX | |||||
Replicase polyprotein 1ab | Unclassified | Kd | 5.12 | CHEMBL |
ID | Source |
---|---|
4017897 | VUID |
N0000146249 | NUI |
D00448 | KEGG_DRUG |
4017897 | VANDF |
4019494 | VANDF |
C0036078 | UMLSCUI |
CHEBI:9334 | CHEBI |
CHEBI:6775 | CHEBI |
SAS | PDB_CHEM_ID |
CHEMBL421 | ChEMBL_ID |
D012460 | MESH_DESCRIPTOR_UI |
DB00795 | DRUGBANK_ID |
5339 | PUBCHEM_CID |
4840 | IUPHAR_LIGAND_ID |
2210 | INN_ID |
3XC8GUZ6CB | UNII |
DB00244 | DRUGBANK_ID |
202770 | RXNORM |
2061 | MMSL |
37855 | MMSL |
37856 | MMSL |
3946 | MMSL |
5056 | MMSL |
5528 | MMSL |
663 | MMSL |
d00379 | MMSL |
d01031 | MMSL |
001600 | NDDF |
002832 | NDDF |
387248006 | SNOMEDCT_US |
387501005 | SNOMEDCT_US |
45844004 | SNOMEDCT_US |
86977007 | SNOMEDCT_US |
4075 | PUBCHEM_CID |
C0127615 | UMLSCUI |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Azulfidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0013-0101 | TABLET | 500 mg | ORAL | NDA | 26 sections |
Azulfidine EN-tabs | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0013-0102 | TABLET, DELAYED RELEASE | 500 mg | ORAL | NDA | 24 sections |
Sulfasalazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-0796 | TABLET | 500 mg | ORAL | ANDA | 25 sections |
Sulfasalazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-0796 | TABLET | 500 mg | ORAL | ANDA | 25 sections |
Sulfasalazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-288 | TABLET | 500 mg | ORAL | ANDA | 29 sections |
Sulfasalazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 23155-019 | TABLET | 500 mg | ORAL | ANDA | 25 sections |
Sulfasalazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-756 | TABLET | 500 mg | ORAL | ANDA | 29 sections |
Sulfasalazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43353-495 | TABLET | 500 mg | ORAL | NDA AUTHORIZED GENERIC | 27 sections |
Sulfasalazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-0086 | TABLET | 500 mg | ORAL | NDA AUTHORIZED GENERIC | 25 sections |
Sulfasalazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-2013 | TABLET | 500 mg | ORAL | ANDA | 25 sections |
Sulfasalazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-2013 | TABLET | 500 mg | ORAL | ANDA | 25 sections |
Sulfasalazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50268-730 | TABLET | 500 mg | ORAL | ANDA | 25 sections |
Sulfasalazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59762-0104 | TABLET, DELAYED RELEASE | 500 mg | ORAL | NDA AUTHORIZED GENERIC | 26 sections |
Sulfasalazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59762-5000 | TABLET | 500 mg | ORAL | NDA AUTHORIZED GENERIC | 26 sections |
Sulfasalazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 62135-960 | TABLET | 500 mg | ORAL | ANDA | 14 sections |
Sulfasalazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-5688 | TABLET | 500 mg | ORAL | ANDA | 25 sections |
Sulfasalazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-5688 | TABLET | 500 mg | ORAL | ANDA | 25 sections |
Sulfasalazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68071-4215 | TABLET | 500 mg | ORAL | ANDA | 25 sections |
Sulfasalazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70518-0185 | TABLET | 500 mg | ORAL | ANDA | 25 sections |
Sulfasalazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70518-0185 | TABLET | 500 mg | ORAL | ANDA | 25 sections |
Sulfasalazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70518-1829 | TABLET | 500 mg | ORAL | NDA authorized generic | 25 sections |
Sulfasalazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70518-2342 | TABLET | 500 mg | ORAL | ANDA | 25 sections |
Sulfasalazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70518-2342 | TABLET | 500 mg | ORAL | ANDA | 25 sections |
Sulfasalazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 71610-577 | TABLET | 500 mg | ORAL | ANDA | 25 sections |