sulfasalazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
phenylazosalicylic acid derivatives antibacterial 2525 599-79-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • salazosulfapyridine
  • salicylazosulfapyridine
  • sulphasalazine
  • azulfidine
  • sulfasalazine
A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
  • Molecular weight: 398.39
  • Formula: C18H14N4O5S
  • CLOGP: 4
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 3
  • TPSA: 141.31
  • ALOGS: -3.93
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2 g O
2 g R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 1.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 167.34 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 15 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.11 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.26 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.00 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 7.60 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
June 20, 1950 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug intolerance 4568.38 14.82 6898 338429 301763 62841932
Drug ineffective 4484.51 14.82 14082 331245 1030683 62113012
Contraindicated product administered 3463.82 14.82 5038 340289 212610 62931085
Treatment failure 3063.97 14.82 4537 340790 194506 62949189
Synovitis 2805.05 14.82 4211 341116 182707 62960988
Joint swelling 2699.85 14.82 5673 339654 321993 62821702
Systemic lupus erythematosus 2410.35 14.82 4177 341150 204741 62938954
Pemphigus 2401.53 14.82 3885 341442 179841 62963854
Arthropathy 2305.64 14.82 4377 340950 230415 62913280
Glossodynia 2236.87 14.82 3708 341619 175168 62968527
Hand deformity 2191.93 14.82 3451 341876 156006 62987689
Therapeutic product effect decreased 1944.32 14.82 3641 341686 189546 62954149
Abdominal discomfort 1925.35 14.82 4907 340420 315978 62827717
Alopecia 1705.75 14.82 4845 340482 332691 62811004
Wound 1692.07 14.82 3117 342210 160146 62983549
Swelling 1644.17 14.82 4205 341122 271173 62872522
Anti-cyclic citrullinated peptide antibody positive 1515.70 14.82 2457 342870 113755 63029940
Musculoskeletal stiffness 1478.21 14.82 3164 342163 181454 62962241
Pericarditis 1383.93 14.82 2529 342798 129050 63014645
Discomfort 1277.26 14.82 2814 342513 164560 62979135
Rheumatoid factor positive 1260.77 14.82 1900 343427 82506 63061189
Death 1239.60 14.82 263 345064 374118 62769577
Hepatic enzyme increased 1224.10 14.82 3107 342220 199221 62944474
Pain 1070.77 14.82 7278 338049 733350 62410345
C-reactive protein abnormal 995.90 14.82 1241 344086 44855 63098840
Product use issue 995.32 14.82 3044 342283 217476 62926219
Therapeutic product effect incomplete 966.36 14.82 2114 343213 122942 63020753
Psoriatic arthropathy 965.32 14.82 1762 343565 89758 63053937
Infusion related reaction 955.50 14.82 3221 342106 242300 62901395
Arthralgia 952.86 14.82 5812 339515 563898 62579797
Rheumatoid arthritis 921.63 14.82 3254 342073 250565 62893130
Duodenal ulcer perforation 921.01 14.82 1680 343647 85529 63058166
Hypersensitivity 914.05 14.82 3574 341753 289111 62854584
Drug hypersensitivity 907.25 14.82 3715 341612 306972 62836723
Helicobacter infection 882.34 14.82 1709 343618 91076 63052619
Acute kidney injury 841.16 14.82 200 345127 263215 62880480
Anaemia 782.07 14.82 309 345018 293121 62850574
Loss of personal independence in daily activities 776.87 14.82 1667 343660 95623 63048072
Completed suicide 743.93 14.82 9 345318 145664 62998031
Hypotension 721.59 14.82 290 345037 272314 62871381
Condition aggravated 719.21 14.82 4179 341148 398038 62745657
Toxicity to various agents 715.80 14.82 227 345100 247023 62896672
Constipation 681.19 14.82 190 345137 224753 62918942
Maternal exposure during pregnancy 658.59 14.82 2653 342674 217409 62926286
C-reactive protein increased 656.57 14.82 1534 343793 93173 63050522
Drug interaction 637.64 14.82 225 345102 228906 62914789
Red blood cell sedimentation rate increased 616.71 14.82 962 344365 43020 63100675
Rash 596.98 14.82 5137 340190 555734 62587961
Dehydration 576.51 14.82 120 345207 173234 62970461
Fall 562.57 14.82 789 344538 391545 62752150
Red blood cell sedimentation rate abnormal 558.09 14.82 611 344716 19171 63124524
Sleep disorder due to general medical condition, insomnia type 551.07 14.82 1006 344321 51211 63092484
Product dose omission issue 547.72 14.82 296 345031 234017 62909678
Dyspnoea 519.35 14.82 1853 343474 659460 62484235
Thrombocytopenia 489.63 14.82 111 345216 151046 62992649
Seizure 472.74 14.82 77 345250 132557 63011138
Asthenia 463.79 14.82 863 344464 382741 62760954
Febrile neutropenia 461.90 14.82 52 345275 118397 63025298
Bone erosion 458.25 14.82 523 344804 17194 63126501
Tremor 457.63 14.82 83 345244 132156 63011539
Mobility decreased 444.45 14.82 1560 343767 119599 63024096
Rheumatic fever 414.26 14.82 798 344529 42313 63101382
Hyponatraemia 400.92 14.82 64 345263 111836 63031859
Inflammation 398.88 14.82 1166 344161 81107 63062588
Folliculitis 396.55 14.82 1053 344274 69264 63074431
Anxiety 393.48 14.82 362 344965 217179 62926516
Neutropenia 393.12 14.82 232 345095 174773 62968922
Muscle injury 390.47 14.82 1000 344327 64345 63079350
Malignant neoplasm progression 387.96 14.82 13 345314 82108 63061587
Blood iron abnormal 386.95 14.82 249 345078 3627 63140068
Diarrhoea 384.40 14.82 2302 343025 713064 62430631
Urinary tract infection 382.24 14.82 529 344798 264155 62879540
Intentional overdose 381.10 14.82 4 345323 74148 63069547
Swollen joint count increased 378.30 14.82 693 344634 35361 63108334
Cardiac arrest 378.06 14.82 34 345293 92511 63051184
Somnolence 377.80 14.82 254 345073 178431 62965264
Infection 370.04 14.82 2321 343006 226852 62916843
Peripheral swelling 370.04 14.82 2595 342732 263347 62880348
Irritable bowel syndrome 369.32 14.82 1136 344191 81276 63062419
Drug abuse 363.54 14.82 6 345321 72512 63071183
Knee arthroplasty 363.48 14.82 867 344460 53339 63090356
Atrial fibrillation 359.44 14.82 95 345232 116541 63027154
Hip arthroplasty 342.32 14.82 783 344544 46863 63096832
Disease progression 340.46 14.82 121 345206 122637 63021058
Blister 337.99 14.82 1501 343826 128313 63015382
Osteoarthritis 328.55 14.82 1203 344124 94140 63049555
Grip strength decreased 321.45 14.82 494 344833 21793 63121902
Tachycardia 320.01 14.82 121 345206 118035 63025660
Cardiac failure congestive 317.63 14.82 59 345268 92374 63051321
Dizziness 314.85 14.82 1238 344089 428687 62715008
Blood cholesterol increased 314.42 14.82 1175 344152 92857 63050838
Balance disorder 312.24 14.82 44 345283 84378 63059317
Platelet count decreased 309.39 14.82 122 345205 116000 63027695
Disability 306.86 14.82 436 344891 17911 63125784
Rheumatoid nodule 305.29 14.82 420 344907 16735 63126960
Liver injury 303.21 14.82 868 344459 59652 63084043
Respiratory failure 298.96 14.82 91 345236 101767 63041928
Bradycardia 293.51 14.82 29 345298 73198 63070497
Impaired healing 289.37 14.82 1215 344112 101327 63042368
Gastrointestinal disorder 289.36 14.82 1446 343881 129793 63013902
Renal failure 283.00 14.82 143 345184 117509 63026186
Cardio-respiratory arrest 281.42 14.82 10 345317 59949 63083746
Vision blurred 275.48 14.82 79 345248 91845 63051850
Cough 273.42 14.82 757 344570 291986 62851709
Hyperkalaemia 269.56 14.82 5 345322 54198 63089497
Type 2 diabetes mellitus 269.17 14.82 862 344465 63006 63080689
Electrocardiogram QT prolonged 269.14 14.82 13 345314 59517 63084178
Drug tolerance decreased 264.31 14.82 396 344931 17077 63126618
Depressed level of consciousness 264.13 14.82 19 345308 62059 63081636
Chest discomfort 259.53 14.82 137 345190 109832 63033863
Overdose 256.30 14.82 154 345173 114924 63028771
Deformity 256.08 14.82 317 345010 11367 63132328
Joint stiffness 255.52 14.82 646 344681 41223 63102472
Suicide attempt 255.34 14.82 20 345307 60898 63082797
Cerebrovascular accident 254.31 14.82 135 345192 107889 63035806
Cardiac failure 253.84 14.82 84 345243 89058 63054637
Oedema peripheral 250.82 14.82 402 344925 189109 62954586
Hypokalaemia 248.41 14.82 127 345200 103677 63040018
Sepsis 248.08 14.82 280 345047 152843 62990852
Pulmonary embolism 247.70 14.82 165 345162 116519 63027176
Ill-defined disorder 246.66 14.82 989 344338 80766 63062929
Gastrointestinal haemorrhage 246.52 14.82 68 345259 81108 63062587
Cognitive disorder 243.59 14.82 15 345312 55800 63087895
Blood parathyroid hormone decreased 241.37 14.82 282 345045 9509 63134186
Multiple sclerosis relapse 238.95 14.82 5 345322 48473 63095222
Granuloma skin 238.65 14.82 261 345066 8176 63135519
Dysphagia 237.72 14.82 92 345235 88493 63055202
Hypoglycaemia 232.52 14.82 27 345300 60038 63083657
Panniculitis 230.65 14.82 297 345030 11088 63132607
Adverse event 228.94 14.82 848 344479 66711 63076984
Fibromyalgia 226.93 14.82 953 344374 79467 63064228
Arthritis 220.29 14.82 1226 344101 114695 63029000
Coma 217.05 14.82 43 345284 64321 63079374
Hypoxia 216.84 14.82 33 345294 59759 63083936
Epistaxis 213.34 14.82 65 345262 72660 63071035
Intentional product use issue 211.57 14.82 1304 344023 126588 63017107
Paraesthesia 209.53 14.82 331 344996 156635 62987060
Myalgia 208.17 14.82 296 345031 146233 62997462
Musculoskeletal pain 205.62 14.82 1020 344307 91257 63052438
Agitation 203.45 14.82 39 345288 59718 63083977
Wrong technique in product usage process 201.31 14.82 46 345281 62294 63081401
Syncope 200.85 14.82 205 345122 117180 63026515
Ankylosing spondylitis 197.86 14.82 264 345063 10210 63133485
Hyperhidrosis 197.72 14.82 177 345150 107659 63036036
Rhabdomyolysis 197.39 14.82 10 345317 43941 63099754
International normalised ratio increased 195.24 14.82 15 345312 46410 63097285
Hallucination 194.84 14.82 32 345295 54785 63088910
Chest pain 193.74 14.82 569 344758 215390 62928305
Dysarthria 190.93 14.82 10 345317 42701 63100994
White blood cell count decreased 189.79 14.82 289 345038 138815 63004880
Lactic acidosis 188.50 14.82 4 345323 38283 63105412
Joint destruction 188.40 14.82 200 345127 6052 63137643
Metabolic acidosis 188.31 14.82 15 345312 45054 63098641
Abdominal pain 185.25 14.82 893 344434 292563 62851132
Fluid retention 183.10 14.82 49 345278 59637 63084058
Neoplasm progression 182.62 14.82 3 345324 36425 63107270
Blood glucose increased 182.42 14.82 115 345212 83641 63060054
Multiple organ dysfunction syndrome 181.03 14.82 43 345284 56709 63086986
Vomiting 180.22 14.82 2062 343265 557555 62586140
Mental status changes 177.87 14.82 9 345318 39590 63104105
Disorientation 177.10 14.82 9 345318 39443 63104252
Chills 176.42 14.82 214 345113 113164 63030531
Injection site pain 175.80 14.82 271 345056 129529 63014166
Sedation 173.75 14.82 9 345318 38800 63104895
Transplant dysfunction 172.50 14.82 170 345157 4702 63138993
Foot deformity 172.29 14.82 432 344895 27421 63116274
Pulmonary oedema 172.25 14.82 43 345284 54830 63088865
Haemoglobin decreased 172.13 14.82 331 344996 145154 62998541
General physical health deterioration 170.59 14.82 1760 343567 199642 62944053
Hyperglycaemia 169.30 14.82 16 345311 41851 63101844
Encephalopathy 166.67 14.82 11 345316 38609 63105086
Neutrophil count decreased 166.19 14.82 50 345277 56356 63087339
Stomatitis 163.27 14.82 1302 344025 137423 63006272
Pancytopenia 162.75 14.82 172 345155 96761 63046934
Feeling abnormal 162.49 14.82 353 344974 148039 62995656
COVID-19 161.10 14.82 228 345099 112875 63030820
Unresponsive to stimuli 160.95 14.82 5 345322 33811 63109884
Skin necrosis 160.22 14.82 279 345048 13671 63130024
Lower respiratory tract infection 158.58 14.82 1247 344080 131060 63012635
Weight decreased 158.46 14.82 871 344456 275927 62867768
Fatigue 157.76 14.82 6106 339221 881922 62261773
Muscle spasms 156.88 14.82 389 344938 155761 62987934
Joint range of motion decreased 156.49 14.82 459 344868 31969 63111726
Haemorrhage 151.51 14.82 71 345256 60951 63082744
Nausea 150.73 14.82 3522 341805 850949 62292746
Enthesopathy 147.43 14.82 207 345120 8407 63135288
Tenosynovitis 146.99 14.82 267 345060 13528 63130167
Neuropathy peripheral 145.75 14.82 246 345081 113421 63030274
Respiratory arrest 144.80 14.82 8 345319 32637 63111058
Dry skin 144.65 14.82 64 345263 56823 63086872
Plasma cell myeloma 141.84 14.82 15 345312 35890 63107805
Musculoskeletal deformity 141.44 14.82 102 345225 1807 63141888
Dyspnoea exertional 140.95 14.82 76 345251 60226 63083469
Blood pressure decreased 140.60 14.82 90 345237 64932 63078763
Pulmonary hypertension 140.45 14.82 18 345309 37105 63106590
Flushing 140.34 14.82 121 345206 74966 63068729
Myocardial infarction 138.68 14.82 205 345122 99688 63044007
Disturbance in attention 138.64 14.82 21 345306 38168 63105527
Gastrooesophageal reflux disease 136.98 14.82 192 345135 95447 63048248
Adverse drug reaction 136.97 14.82 821 344506 78893 63064802
Hypervolaemia 135.96 14.82 4 345323 28409 63115286
Musculoskeletal disorder 135.96 14.82 328 344999 20316 63123379
Blood potassium decreased 135.71 14.82 31 345296 41995 63101700
Lethargy 134.74 14.82 68 345259 55939 63087756
Respiratory distress 134.59 14.82 14 345313 33937 63109758
Decreased appetite 134.52 14.82 807 344520 250245 62893450
Intentional product misuse 133.53 14.82 83 345244 60834 63082861
Dyskinesia 132.73 14.82 11 345316 31991 63111704
Polyarthritis 132.61 14.82 215 345112 9931 63133764
Blood pressure increased 132.59 14.82 445 344882 161617 62982078
Acute respiratory failure 132.23 14.82 16 345311 34469 63109226
Sciatica 130.94 14.82 448 344879 33876 63109819
Serotonin syndrome 130.49 14.82 6 345321 28676 63115019
Back pain 129.77 14.82 872 344455 263273 62880422
Chronic obstructive pulmonary disease 128.53 14.82 92 345235 62594 63081101
Irritability 125.82 14.82 13 345314 31681 63112014
Pleural effusion 125.81 14.82 195 345132 93015 63050680
Therapeutic response decreased 125.78 14.82 664 344663 60861 63082834
Restlessness 125.32 14.82 9 345318 29444 63114251
Blood bilirubin increased 124.82 14.82 25 345302 37115 63106580
Bone pain 124.62 14.82 71 345256 54570 63089125
Liver function test increased 124.07 14.82 427 344900 32384 63111311
Transient ischaemic attack 123.61 14.82 27 345300 37726 63105969
Drug withdrawal syndrome 122.71 14.82 6 345321 27188 63116507
Pneumonia 122.67 14.82 1748 343579 455019 62688676
Aphasia 122.46 14.82 17 345310 32983 63110712
Ascites 122.00 14.82 35 345292 40693 63103002
Red blood cell sedimentation rate 121.64 14.82 141 345186 4713 63138982
Injection site erythema 121.10 14.82 165 345162 83009 63060686
Abdominal distension 120.96 14.82 177 345150 86438 63057257
Pneumonia aspiration 120.89 14.82 21 345306 34519 63109176
Orthostatic hypotension 120.16 14.82 25 345302 36135 63107560
Dysgeusia 119.63 14.82 52 345275 46658 63097037
Drug eruption 117.87 14.82 384 344943 28310 63115385
Hepatic failure 117.76 14.82 25 345302 35631 63108064
Seronegative arthritis 116.39 14.82 125 345202 3834 63139861
Hypophagia 116.24 14.82 16 345311 31243 63112452
Cellulitis 114.93 14.82 167 345160 81791 63061904
Body height below normal 114.44 14.82 95 345232 2088 63141607
Haematoma 113.81 14.82 25 345302 34795 63108900
Pulmonary fibrosis 113.21 14.82 473 344854 39336 63104359
Palpitations 113.18 14.82 281 345046 112489 63031206
Dysuria 112.78 14.82 23 345304 33715 63109980
Asthma 111.49 14.82 340 344987 127221 63016474
Physical disability 110.77 14.82 103 345224 2645 63141050
Full blood count decreased 110.59 14.82 8 345319 26016 63117679
Ulcer 110.52 14.82 353 344974 25754 63117941
Hospitalisation 110.11 14.82 183 345144 84898 63058797
Human antichimeric antibody positive 109.99 14.82 84 345243 1630 63142065
X-ray abnormal 108.92 14.82 174 345153 7936 63135759
Pyrexia 108.89 14.82 1852 343475 468626 62675069
Dislocation of vertebra 108.82 14.82 180 345147 8455 63135240
Skin exfoliation 108.79 14.82 49 345278 43053 63100642
Pallor 108.28 14.82 18 345309 30550 63113145
Generalised tonic-clonic seizure 107.55 14.82 15 345312 29001 63114694
Cerebral haemorrhage 106.86 14.82 19 345308 30710 63112985
Depression 105.53 14.82 631 344696 195861 62947834
Deep vein thrombosis 105.00 14.82 184 345143 83616 63060079
Chronic kidney disease 104.96 14.82 58 345269 45340 63098355
Urinary retention 104.80 14.82 19 345308 30282 63113413
Arrhythmia 103.31 14.82 39 345288 38101 63105594
Exostosis 102.15 14.82 269 345058 17593 63126102
Osteonecrosis of jaw 101.90 14.82 32 345295 35091 63108604
Blood urea increased 101.73 14.82 12 345315 26367 63117328
Melaena 100.88 14.82 21 345306 30344 63113351
Obstructive airways disorder 98.73 14.82 3 345324 20696 63122999
Pulmonary arterial hypertension 98.71 14.82 6 345321 22571 63121124
Altered state of consciousness 98.49 14.82 11 345316 25219 63118476
Aggression 97.66 14.82 8 345319 23490 63120205
Urinary incontinence 96.83 14.82 27 345300 31987 63111708
Hip fracture 96.66 14.82 21 345306 29453 63114242
Product quality issue 96.60 14.82 37 345290 35828 63107867
Psychotic disorder 95.99 14.82 13 345314 25699 63117996
Breast cancer stage III 95.77 14.82 189 345138 10197 63133498
Haematuria 95.16 14.82 21 345306 29136 63114559
Finger deformity 94.34 14.82 159 345168 7586 63136109
Therapy interrupted 93.39 14.82 30 345297 32425 63111270
Hot flush 92.51 14.82 85 345242 51074 63092621
Onychomycosis 91.56 14.82 159 345168 7773 63135922
Vaginal haemorrhage 91.34 14.82 19 345308 27468 63116227
Hypomagnesaemia 91.19 14.82 22 345305 28715 63114980
Blood sodium decreased 91.17 14.82 12 345315 24240 63119455
Joint effusion 90.60 14.82 250 345077 16810 63126885
Therapy cessation 89.71 14.82 27 345300 30430 63113265
Wheelchair user 89.61 14.82 139 345188 6180 63137515
Abortion spontaneous 89.47 14.82 75 345252 47120 63096575
Foetal exposure during pregnancy 89.43 14.82 31 345296 31931 63111764
Device issue 88.84 14.82 12 345315 23769 63119926
Emotional distress 88.63 14.82 33 345294 32516 63111179
Throat irritation 88.63 14.82 47 345280 37600 63106095
Metastases to bone 87.79 14.82 7 345320 21012 63122683
Prescribed overdose 87.31 14.82 393 344934 33760 63109935
Premature delivery 87.12 14.82 28 345299 30253 63113442
Lymphocyte count decreased 87.01 14.82 28 345299 30229 63113466
Incorrect dose administered 86.24 14.82 120 345207 59848 63083847
Drug level increased 86.07 14.82 11 345316 22725 63120970
Electrolyte imbalance 85.80 14.82 6 345321 20070 63123625
Clostridium difficile colitis 85.49 14.82 7 345320 20562 63123133
Basal cell carcinoma 85.47 14.82 340 344987 27651 63116044
Therapy non-responder 85.24 14.82 705 344622 75196 63068499
Upper respiratory tract infection 85.03 14.82 201 345126 81846 63061849
Accidental exposure to product 84.99 14.82 22 345305 27383 63116312
Suicidal ideation 84.78 14.82 130 345197 62291 63081404
Sinus tachycardia 84.40 14.82 15 345312 24253 63119442
Full blood count abnormal 83.32 14.82 34 345293 31683 63112012
Ventricular tachycardia 82.49 14.82 7 345320 19972 63123723
Drug ineffective for unapproved indication 82.47 14.82 41 345286 34022 63109673
Hepatitis 82.40 14.82 431 344896 39357 63104338
Depressed mood 82.37 14.82 59 345268 40132 63103563
Skin ulcer 82.18 14.82 456 344871 42589 63101106
Oropharyngeal pain 81.73 14.82 253 345074 94234 63049461
Nervousness 81.72 14.82 33 345294 30946 63112749
Prescribed underdose 81.50 14.82 349 344978 29340 63114355
Vascular access complication 80.80 14.82 77 345250 2041 63141654
Red cell distribution width decreased 80.55 14.82 76 345251 1989 63141706
Withdrawal syndrome 79.90 14.82 8 345319 19989 63123706
Diplopia 79.68 14.82 16 345311 23712 63119983
Hepatotoxicity 79.32 14.82 405 344922 36636 63107059
Device dislocation 79.02 14.82 21 345306 25684 63118011
Anti-cyclic citrullinated peptide antibody 78.70 14.82 136 345191 6622 63137073
Feeling hot 78.34 14.82 95 345232 50259 63093436
Oxygen saturation decreased 78.19 14.82 235 345092 88350 63055345
Cardiac disorder 77.87 14.82 97 345230 50719 63092976
Speech disorder 77.71 14.82 64 345263 40565 63103130
Head injury 77.64 14.82 26 345301 27370 63116325
Colitis 77.16 14.82 90 345237 48438 63095257
Antibody test positive 77.00 14.82 84 345243 2623 63141072
Sleep apnoea syndrome 76.91 14.82 31 345296 29102 63114593
Mental disorder 76.30 14.82 23 345304 25896 63117799
Blood creatine phosphokinase increased 76.16 14.82 35 345292 30395 63113300
Bone marrow failure 75.97 14.82 32 345295 29258 63114437
Cholelithiasis 75.91 14.82 76 345251 43849 63099846
Jaundice 75.80 14.82 32 345295 29219 63114476
Complication associated with device 75.80 14.82 4 345323 16974 63126721
Muscle twitching 75.71 14.82 9 345318 19659 63124036
Lacrimation increased 75.68 14.82 11 345316 20620 63123075
Coagulopathy 75.26 14.82 11 345316 20533 63123162
Retinitis 75.20 14.82 127 345200 6069 63137626
Ejection fraction decreased 75.11 14.82 15 345312 22317 63121378
Vertigo 74.56 14.82 132 345195 59755 63083940
Joint dislocation 74.00 14.82 248 345079 18552 63125143
Acute myocardial infarction 72.88 14.82 42 345285 32082 63111613
Rectal haemorrhage 72.64 14.82 96 345231 48934 63094761
Shock 72.45 14.82 19 345308 23444 63120251
Pollakiuria 71.70 14.82 31 345296 27906 63115789
Product administration error 71.36 14.82 17 345310 22380 63121315
Headache 70.80 14.82 2773 342554 630468 62513227
Pulmonary toxicity 70.79 14.82 158 345169 9297 63134398
Dactylitis 70.75 14.82 79 345248 2533 63141162
Memory impairment 70.56 14.82 309 345018 103949 63039746
Cholestasis 70.40 14.82 36 345291 29398 63114297
Myoclonus 70.03 14.82 4 345323 15864 63127831
Pancreatitis acute 69.95 14.82 30 345297 27136 63116559
Status epilepticus 69.91 14.82 3 345324 15230 63128465
Transplant rejection 69.61 14.82 170 345157 10610 63133085
Contusion 69.55 14.82 1175 344152 148869 62994826
Surgery 69.40 14.82 56 345271 35856 63107839
Nail disorder 69.39 14.82 191 345136 12824 63130871
Mean platelet volume decreased 69.36 14.82 79 345248 2590 63141105
Upper gastrointestinal haemorrhage 69.28 14.82 10 345317 18842 63124853
Hallucination, visual 69.17 14.82 11 345316 19287 63124408
Posterior reversible encephalopathy syndrome 69.15 14.82 7 345320 17338 63126357
International normalised ratio fluctuation 68.94 14.82 76 345251 2402 63141293
Angina pectoris 68.70 14.82 39 345288 30039 63113656
Visual acuity reduced 68.69 14.82 17 345310 21809 63121886
Blood glucose decreased 68.56 14.82 15 345312 20937 63122758
Right ventricular failure 68.36 14.82 7 345320 17181 63126514
Blood alkaline phosphatase increased 67.98 14.82 80 345247 42887 63100808
Rheumatoid factor negative 67.87 14.82 42 345285 569 63143126
No adverse event 67.78 14.82 75 345252 41330 63102365
Infusion site pain 66.75 14.82 7 345320 16862 63126833
Muscular weakness 66.66 14.82 391 344936 121962 63021733
Hepatocellular injury 66.22 14.82 33 345294 27348 63116347
Adjustment disorder with depressed mood 65.98 14.82 161 345166 10043 63133652
Heart rate increased 65.80 14.82 276 345051 93962 63049733
Product label confusion 65.30 14.82 64 345263 1758 63141937
Lupus-like syndrome 64.91 14.82 207 345120 15088 63128607
Device related infection 64.91 14.82 23 345304 23369 63120326
Loss of consciousness 64.61 14.82 377 344950 117744 63025951
Pulmonary congestion 64.57 14.82 9 345318 17409 63126286
Pericardial effusion 64.43 14.82 42 345285 30016 63113679
Hemiparesis 64.42 14.82 23 345304 23259 63120436
Tachypnoea 63.99 14.82 9 345318 17293 63126402
Impaired work ability 63.96 14.82 225 345102 17250 63126445
Premature baby 63.63 14.82 17 345310 20718 63122977
Circulatory collapse 63.62 14.82 20 345307 21918 63121777
Erythema 63.40 14.82 630 344697 175121 62968574
Rash erythematous 63.22 14.82 83 345244 42427 63101268
Sinus bradycardia 63.21 14.82 4 345323 14547 63129148
Product prescribing error 63.10 14.82 32 345295 26257 63117438
Renal impairment 62.79 14.82 257 345070 88098 63055597
Cardiogenic shock 62.54 14.82 11 345316 17921 63125774
Injury 62.33 14.82 641 344686 72606 63071089
Angioedema 62.20 14.82 103 345224 47862 63095833
Neoplasm malignant 62.20 14.82 324 345003 29537 63114158
Hyperlipidaemia 62.07 14.82 15 345312 19556 63124139
Fear of injection 62.03 14.82 127 345200 7037 63136658
Throat tightness 61.70 14.82 29 345298 24858 63118837
Accidental overdose 61.21 14.82 25 345302 23284 63120411
Infusion site reaction 61.09 14.82 86 345241 3501 63140194
Hypersomnia 60.99 14.82 12 345315 18043 63125652
Deep vein thrombosis postoperative 60.77 14.82 167 345160 11202 63132493
Coronary artery disease 60.70 14.82 52 345275 32325 63111370
Lip swelling 60.57 14.82 48 345279 31015 63112680
Live birth 60.40 14.82 288 345039 25342 63118353
Bloody discharge 60.34 14.82 57 345270 1494 63142201
Labelled drug-drug interaction medication error 60.32 14.82 3 345324 13396 63130299
Nasal congestion 60.25 14.82 171 345156 65489 63078206
Tenderness 60.12 14.82 263 345064 22315 63121380
Presbyacusis 60.01 14.82 76 345251 2789 63140906
Product substitution issue 59.92 14.82 8 345319 15988 63127707
Cyanosis 59.92 14.82 10 345317 16925 63126770
Ovarian cyst 59.83 14.82 207 345120 15738 63127957
Bacteraemia 59.73 14.82 11 345316 17337 63126358
Swollen tongue 59.23 14.82 61 345266 34739 63108956
Restless legs syndrome 59.17 14.82 14 345313 18517 63125178
Eye swelling 59.10 14.82 28 345299 23890 63119805
Toxic epidermal necrolysis 59.09 14.82 32 345295 25302 63118393
Haemoptysis 59.09 14.82 42 345285 28684 63115011
Blindness 59.08 14.82 22 345305 21677 63122018
Obesity 58.98 14.82 320 345007 29632 63114063
Poisoning 58.83 14.82 4 345323 13696 63129999
Wrist deformity 58.69 14.82 65 345262 2065 63141630
Swelling face 58.47 14.82 165 345162 63310 63080385
Ataxia 58.38 14.82 7 345320 15188 63128507
Insomnia 58.23 14.82 822 344505 214430 62929265
Progressive multifocal leukoencephalopathy 58.09 14.82 3 345324 12968 63130727
Pain in extremity 57.56 14.82 2276 343051 329210 62814485
Cytomegalovirus infection 57.46 14.82 21 345306 20931 63122764
Haemorrhage intracranial 57.38 14.82 4 345323 13415 63130280
Nasopharyngitis 57.36 14.82 1799 343528 252458 62891237
Device difficult to use 57.17 14.82 3 345324 12793 63130902
Onychomadesis 57.17 14.82 109 345218 5731 63137964
Myelodysplastic syndrome 56.88 14.82 11 345316 16743 63126952
Haematemesis 56.82 14.82 49 345278 30363 63113332
Extrapyramidal disorder 56.69 14.82 4 345323 13280 63130415
Dystonia 56.62 14.82 5 345322 13814 63129881
Mitral valve incompetence 56.57 14.82 18 345309 19576 63124119
Metastases to liver 56.40 14.82 29 345298 23610 63120085
Coordination abnormal 56.39 14.82 5 345322 13768 63129927
Small intestinal obstruction 56.33 14.82 15 345312 18322 63125373
Acute hepatic failure 56.29 14.82 15 345312 18312 63125383
Blood magnesium decreased 56.24 14.82 4 345323 13194 63130501
Bone swelling 55.98 14.82 57 345270 1641 63142054
Dysphonia 55.68 14.82 109 345218 47505 63096190
Retching 55.64 14.82 7 345320 14638 63129057
Flatulence 55.55 14.82 64 345263 34638 63109057
Presyncope 55.37 14.82 42 345285 27743 63115952
Osteoporosis 55.24 14.82 515 344812 56823 63086872
Lower limb fracture 54.80 14.82 269 345058 23952 63119743
Hypercalcaemia 54.70 14.82 301 345026 28021 63115674
Mucosal inflammation 54.39 14.82 108 345219 46820 63096875
Joint injury 54.28 14.82 310 345017 29262 63114433
Panic attack 53.87 14.82 27 345300 22304 63121391
Diabetic ketoacidosis 53.83 14.82 22 345305 20483 63123212
Cystitis 53.62 14.82 139 345188 54852 63088843
Pleural thickening 53.43 14.82 72 345255 2811 63140884
Drug specific antibody 53.39 14.82 65 345262 2290 63141405
Paraesthesia oral 53.31 14.82 19 345308 19237 63124458
Mycotic allergy 53.04 14.82 44 345283 966 63142729
Osteonecrosis 52.95 14.82 34 345293 24496 63119199
Bursitis 52.82 14.82 364 344963 36677 63107018
Acute myeloid leukaemia 52.73 14.82 14 345313 17133 63126562
Adverse reaction 52.68 14.82 148 345179 10055 63133640
Blood creatinine increased 52.62 14.82 272 345055 87572 63056123
Staphylococcal infection 52.20 14.82 90 345237 41166 63102529
Dermatitis allergic 52.00 14.82 191 345136 14957 63128738
Sinus disorder 51.69 14.82 35 345292 24518 63119177
Mean cell volume decreased 51.58 14.82 84 345243 3894 63139801
Pleural fibrosis 51.52 14.82 78 345249 3394 63140301
Facet joint syndrome 51.26 14.82 164 345163 11974 63131721
Gastrointestinal toxicity 50.97 14.82 123 345204 7618 63136077
Ischaemic stroke 50.96 14.82 17 345310 17940 63125755
Metastases to central nervous system 50.44 14.82 6 345321 13099 63130596
Hypercholesterolaemia 49.75 14.82 239 345088 21095 63122600
Macular degeneration 49.67 14.82 36 345291 24340 63119355
Dementia 49.61 14.82 20 345307 18774 63124921
Inappropriate schedule of product administration 49.58 14.82 346 344981 103619 63040076
Hyperbilirubinaemia 49.48 14.82 3 345324 11311 63132384
Leukocytosis 49.42 14.82 41 345286 25894 63117801
Arthrodesis 48.96 14.82 68 345259 2733 63140962
Tricuspid valve incompetence 48.80 14.82 10 345317 14611 63129084
Respiratory depression 48.74 14.82 8 345319 13707 63129988
Bone density abnormal 48.54 14.82 75 345252 3323 63140372
Eosinophilia 48.50 14.82 32 345295 22724 63120971
Abdominal pain lower 48.43 14.82 41 345286 25637 63118058
Coeliac disease 47.90 14.82 166 345161 12631 63131064
Cerebral infarction 47.76 14.82 36 345291 23857 63119838
Viral infection 47.73 14.82 75 345252 35588 63108107
Tenosynovitis stenosans 47.70 14.82 74 345253 3290 63140405
Bronchitis 47.52 14.82 442 344885 124493 63019202
Hypothyroidism 46.97 14.82 101 345226 42531 63101164
Caesarean section 46.82 14.82 17 345310 17015 63126680
Brain oedema 46.78 14.82 10 345317 14185 63129510
Mania 46.77 14.82 6 345321 12361 63131334
Injection site swelling 46.57 14.82 120 345207 47452 63096243
Acute respiratory distress syndrome 46.35 14.82 36 345291 23498 63120197
Hypovolaemia 46.17 14.82 3 345324 10670 63133025
Lymphopenia 45.99 14.82 21 345306 18306 63125389
Multiple sclerosis 45.86 14.82 39 345288 24333 63119362
Tinnitus 45.74 14.82 77 345250 35551 63108144
Gastritis 45.73 14.82 83 345244 37220 63106475
Peritonitis 45.69 14.82 18 345309 17136 63126559
Thrombosis 45.60 14.82 189 345138 64566 63079129
Incontinence 45.58 14.82 5 345322 11627 63132068
Device malfunction 45.53 14.82 20 345307 17837 63125858
Productive cough 45.44 14.82 183 345144 63025 63080670
Tuberculin test positive 45.34 14.82 74 345253 3437 63140258
Gamma-glutamyltransferase increased 45.13 14.82 72 345255 33959 63109736
Hyperthyroidism 45.08 14.82 12 345315 14661 63129034
Left ventricular dysfunction 44.90 14.82 6 345321 11982 63131713
Hypophosphataemia 44.55 14.82 5 345322 11421 63132274
Renal disorder 44.46 14.82 69 345258 32905 63110790
Thyroid neoplasm 44.36 14.82 79 345248 3940 63139755
Influenza 44.26 14.82 378 344949 108344 63035351
Neck deformity 44.01 14.82 56 345271 2065 63141630
Extremity contracture 43.94 14.82 44 345283 1241 63142454
Lupus vulgaris 43.57 14.82 99 345228 5895 63137800
Subdural haematoma 43.49 14.82 12 345315 14316 63129379
Lip dry 43.34 14.82 183 345144 15287 63128408
Blood magnesium increased 43.32 14.82 67 345260 2971 63140724
Injection site haemorrhage 43.25 14.82 41 345286 24273 63119422
Supraventricular tachycardia 43.23 14.82 12 345315 14259 63129436
Central nervous system lesion 43.16 14.82 4 345323 10631 63133064
Arteriosclerosis 43.04 14.82 3 345324 10063 63133632
Wound infection 43.01 14.82 230 345097 21180 63122515
Acute generalised exanthematous pustulosis 42.92 14.82 5 345322 11094 63132601
Premature labour 42.90 14.82 8 345319 12496 63131199
Malnutrition 42.52 14.82 15 345312 15283 63128412
Kidney infection 42.50 14.82 38 345289 23138 63120557
Dermatitis contact 42.47 14.82 5 345322 11003 63132692
Sensory disturbance 42.35 14.82 11 345316 13661 63130034
Sudden death 42.22 14.82 4 345323 10445 63133250
Shock haemorrhagic 42.16 14.82 3 345324 9892 63133803
Back injury 42.15 14.82 132 345195 9528 63134167
Liver disorder 42.01 14.82 462 344865 53225 63090470
White blood cell count abnormal 41.98 14.82 100 345227 6142 63137553
Anal incontinence 41.90 14.82 11 345316 13565 63130130
Interstitial lung disease 41.88 14.82 518 344809 61390 63082305
Aspiration 41.68 14.82 5 345322 10846 63132849
Subarachnoid haemorrhage 41.45 14.82 13 345314 14270 63129425
Rhinitis allergic 41.32 14.82 7 345320 11720 63131975
Ventricular extrasystoles 41.13 14.82 7 345320 11680 63132015
Haematochezia 41.08 14.82 151 345176 53393 63090302
Bone density decreased 41.05 14.82 173 345154 14439 63129256
Product storage error 40.99 14.82 15 345312 14941 63128754
Mental impairment 40.86 14.82 13 345314 14138 63129557
Rash macular 40.85 14.82 40 345287 23324 63120371
Blood triglycerides increased 40.74 14.82 9 345318 12479 63131216
Ageusia 40.74 14.82 12 345315 13716 63129979
Hepatic cirrhosis 40.71 14.82 252 345075 24482 63119213
Chromaturia 40.65 14.82 20 345307 16697 63126998
Feeling cold 40.51 14.82 42 345285 23846 63119849
Femur fracture 40.36 14.82 106 345221 41650 63102045
Hallucination, auditory 40.33 14.82 10 345317 12814 63130881
Ovarian neoplasm 40.28 14.82 36 345291 877 63142818
Cardiac failure acute 40.25 14.82 3 345324 9520 63134175
Drug tolerance 40.09 14.82 105 345222 6844 63136851
Epilepsy 40.08 14.82 53 345274 27012 63116683
Lung disorder 40.01 14.82 516 344811 61745 63081950
Inappropriate antidiuretic hormone secretion 39.93 14.82 17 345310 15445 63128250
Skin burning sensation 39.91 14.82 10 345317 12724 63130971
Stress cardiomyopathy 39.88 14.82 3 345324 9447 63134248
Skin discolouration 39.72 14.82 92 345235 37736 63105959
Synovial fluid analysis 39.47 14.82 57 345270 2376 63141319
Drug dependence 39.36 14.82 45 345282 24438 63119257
Mean cell haemoglobin decreased 39.28 14.82 87 345240 5092 63138603
Infusion site erythema 38.95 14.82 8 345319 11671 63132024
Acidosis 38.94 14.82 7 345320 11226 63132469
Fine motor skill dysfunction 38.82 14.82 83 345244 4742 63138953
Atrial flutter 38.81 14.82 4 345323 9768 63133927
Iron deficiency anaemia 38.76 14.82 31 345296 19938 63123757
Myelosuppression 38.72 14.82 43 345284 23660 63120035
Limb injury 38.65 14.82 49 345278 25428 63118267
Sensory loss 38.64 14.82 5 345322 10233 63133462
Incorrect product administration duration 38.32 14.82 8 345319 11538 63132157
Device breakage 38.30 14.82 8 345319 11534 63132161
Sleep disorder 38.22 14.82 640 344687 80926 63062769
Malaise 38.17 14.82 1861 343466 414093 62729602
Metastases to lung 38.10 14.82 11 345316 12739 63130956
Acute coronary syndrome 38.08 14.82 5 345322 10121 63133574
Respiratory tract infection 38.08 14.82 108 345219 41375 63102320
Sinus congestion 37.93 14.82 26 345301 18097 63125598
Thrombotic microangiopathy 37.89 14.82 6 345321 10555 63133140
Foetal death 37.72 14.82 7 345320 10973 63132722
Rheumatic disorder 37.33 14.82 63 345264 3009 63140686
Rhinorrhoea 37.08 14.82 207 345120 65370 63078325
Hepatic encephalopathy 37.07 14.82 8 345319 11274 63132421
Lymphoedema 37.00 14.82 9 345318 11683 63132012
Paranoia 36.94 14.82 9 345318 11670 63132025
Diabetes mellitus inadequate control 36.93 14.82 18 345309 15108 63128587
Gout 36.90 14.82 13 345314 13258 63130437
Chronic sinusitis 36.72 14.82 12 345315 12831 63130864
Blood urine present 36.68 14.82 18 345309 15051 63128644
Breast cancer metastatic 36.60 14.82 10 345317 12008 63131687
Procedural pain 36.49 14.82 38 345289 21531 63122164
Cholecystitis 36.49 14.82 19 345308 15358 63128337
Nodule 36.37 14.82 217 345110 20809 63122886
Body temperature increased 36.27 14.82 94 345233 37098 63106597
Haemodynamic instability 35.89 14.82 4 345323 9186 63134509
Oral discomfort 35.88 14.82 121 345206 9080 63134615
Alanine aminotransferase abnormal 35.68 14.82 77 345250 4427 63139268
Faeces discoloured 35.59 14.82 29 345298 18480 63125215
Hiatus hernia 35.47 14.82 39 345288 21555 63122140
Klebsiella infection 35.37 14.82 3 345324 8563 63135132
Hepatic cytolysis 35.15 14.82 20 345307 15387 63128308
Deafness neurosensory 35.08 14.82 80 345247 4775 63138920
Dialysis 35.07 14.82 7 345320 10420 63133275
Anger 34.98 14.82 12 345315 12444 63131251
Injection site mass 34.92 14.82 30 345297 18626 63125069
Maternal exposure timing unspecified 34.84 14.82 101 345226 6986 63136709
Diverticulum 34.65 14.82 11 345316 11980 63131715
Hepatic enzyme abnormal 34.27 14.82 94 345233 6298 63137397
Heart rate irregular 34.14 14.82 43 345284 22378 63121317
Skin irritation 33.92 14.82 6 345321 9735 63133960
Neutropenic sepsis 33.85 14.82 24 345303 16414 63127281
Hypoalbuminaemia 33.81 14.82 11 345316 11794 63131901
Gait inability 33.64 14.82 438 344889 52521 63091174
Troponin increased 33.62 14.82 7 345320 10114 63133581
Vaginal discharge 33.52 14.82 5 345322 9193 63134502
Acute pulmonary oedema 33.29 14.82 3 345324 8155 63135540
Seasonal allergy 33.14 14.82 39 345288 20911 63122784
Prothrombin time prolonged 33.06 14.82 6 345321 9558 63134137
Disseminated intravascular coagulation 32.87 14.82 33 345294 19018 63124677
Injection site pruritus 32.82 14.82 130 345197 44986 63098709
Urticaria 32.82 14.82 670 344657 165132 62978563
Gastroenteritis 32.74 14.82 59 345268 26531 63117164
Lung infiltration 32.68 14.82 19 345308 14444 63129251
Hypoaesthesia oral 32.60 14.82 15 345312 13018 63130677
Abdominal pain upper 32.28 14.82 865 344462 205579 62938116
Gingival bleeding 32.25 14.82 14 345313 12573 63131122
Rash papular 32.24 14.82 23 345304 15679 63128016
Autoimmune disorder 32.14 14.82 181 345146 16996 63126699
Oesophagitis 32.13 14.82 21 345306 14987 63128708
Synovial cyst 32.06 14.82 127 345200 10306 63133389
Infusion site swelling 31.95 14.82 7 345320 9763 63133932
Psoriasis 31.94 14.82 657 344670 86300 63057395
Hemiplegia 31.91 14.82 6 345321 9317 63134378
Spinal stenosis 31.81 14.82 163 345164 14762 63128933
Gastric ulcer 31.74 14.82 51 345276 23986 63119709
Rib fracture 31.71 14.82 46 345281 22551 63121144
Neutrophil count increased 31.65 14.82 26 345301 16501 63127194
Septic shock 31.64 14.82 222 345105 66407 63077288
Peripheral venous disease 31.59 14.82 167 345160 15310 63128385
C-reactive protein 31.53 14.82 77 345250 4805 63138890
Eye pruritus 31.47 14.82 33 345294 18638 63125057
Immobile 31.47 14.82 87 345240 5856 63137839
Sinusitis 31.45 14.82 1521 343806 225132 62918563
Mass excision 31.00 14.82 21 345306 335 63143360
Dental caries 30.95 14.82 10 345317 10769 63132926
Scleritis 30.94 14.82 72 345255 4356 63139339
Lyme disease 30.88 14.82 62 345265 3387 63140308
Cardiomyopathy 30.87 14.82 30 345297 17554 63126141
Metastases to lymph nodes 30.75 14.82 4 345323 8154 63135541
Respiratory rate increased 30.74 14.82 18 345309 13630 63130065
Nervous system disorder 30.70 14.82 34 345293 18732 63124963
Nocturia 30.67 14.82 4 345323 8137 63135558
Colitis ischaemic 30.63 14.82 10 345317 10698 63132997
Peripheral coldness 30.43 14.82 14 345313 12151 63131544
Renal injury 30.40 14.82 7 345320 9432 63134263
Myocardial ischaemia 30.35 14.82 16 345311 12843 63130852
Hepatic function abnormal 30.33 14.82 102 345225 37040 63106655
Polyuria 30.32 14.82 5 345322 8537 63135158
Intestinal obstruction 30.20 14.82 78 345249 30821 63112874
Ankle arthroplasty 30.18 14.82 43 345284 1770 63141925
Generalised oedema 30.15 14.82 25 345302 15793 63127902
Peptic ulcer haemorrhage 30.13 14.82 33 345294 1035 63142660
Apnoea 30.08 14.82 4 345323 8018 63135677
Blood calcium increased 29.98 14.82 7 345320 9343 63134352
Muscle spasticity 29.96 14.82 45 345282 21749 63121946
Glomerular filtration rate decreased 29.88 14.82 18 345309 13423 63130272
Bone cyst 29.78 14.82 48 345279 2206 63141489
Unevaluable event 29.71 14.82 161 345166 51225 63092470
Faecaloma 29.68 14.82 4 345323 7937 63135758
Arteriosclerosis coronary artery 29.50 14.82 5 345322 8368 63135327
Lower gastrointestinal haemorrhage 29.43 14.82 4 345323 7886 63135809
Pancreatitis 29.31 14.82 152 345175 48903 63094792
Eructation 29.31 14.82 5 345322 8328 63135367
Injection site bruising 29.09 14.82 123 345204 41787 63101908
Jaundice cholestatic 29.08 14.82 3 345324 7321 63136374
Nightmare 29.03 14.82 37 345290 19157 63124538
Ecchymosis 28.96 14.82 12 345315 11082 63132613
Amenorrhoea 28.81 14.82 9 345318 9905 63133790
Nephropathy toxic 28.65 14.82 8 345319 9471 63134224
Intestinal sepsis 28.59 14.82 19 345308 293 63143402
Sacroiliitis 28.51 14.82 58 345269 3199 63140496
Abdominal tenderness 28.50 14.82 5 345322 8161 63135534
Escherichia infection 28.47 14.82 17 345310 12737 63130958
Cold sweat 28.41 14.82 15 345312 12032 63131663
Ileus 28.40 14.82 23 345304 14702 63128993
Tooth disorder 28.36 14.82 70 345257 28087 63115608
Thirst 28.26 14.82 21 345306 14020 63129675
Rales 28.24 14.82 17 345310 12680 63131015
Agranulocytosis 28.14 14.82 59 345268 25075 63118620
Therapeutic product effect variable 28.12 14.82 34 345293 1189 63142506
Uveitis 28.10 14.82 139 345188 12414 63131281
Neuralgia 28.08 14.82 62 345265 25864 63117831
Tongue disorder 27.98 14.82 123 345204 10457 63133238
Pseudomonas infection 27.90 14.82 13 345314 11200 63132495
Walking aid user 27.90 14.82 124 345203 10593 63133102
Post procedural complication 27.86 14.82 31 345296 17043 63126652
Hereditary angioedema 27.81 14.82 4 345323 7558 63136137
Gallbladder disorder 27.80 14.82 37 345290 18805 63124890
Bundle branch block left 27.75 14.82 3 345324 7056 63136639
Infusion site extravasation 27.67 14.82 11 345316 10415 63133280
Eating disorder 27.39 14.82 38 345289 18978 63124717
Aplastic anaemia 27.26 14.82 9 345318 9560 63134135
Lipase increased 27.02 14.82 10 345317 9890 63133805
Monocyte count increased 27.01 14.82 96 345231 7397 63136298
Activated partial thromboplastin time prolonged 26.92 14.82 3 345324 6890 63136805
Dizziness postural 26.90 14.82 4 345323 7372 63136323
Breast cancer stage I 26.90 14.82 3 345324 6886 63136809
Eosinophil count increased 26.68 14.82 13 345314 10915 63132780
Bronchopulmonary aspergillosis 26.65 14.82 7 345320 8628 63135067
Immune thrombocytopenia 26.63 14.82 12 345315 10544 63133151
Vascular device infection 26.59 14.82 4 345323 7308 63136387
Skin laceration 26.54 14.82 52 345275 22656 63121039
Coronary artery occlusion 26.53 14.82 6 345321 8185 63135510
Tuberculosis 26.43 14.82 126 345201 11085 63132610
Hyperaesthesia 26.31 14.82 9 345318 9349 63134346
Dermatitis bullous 26.06 14.82 7 345320 8501 63135194
Eye haemorrhage 26.00 14.82 7 345320 8489 63135206
Pulmonary haemorrhage 25.95 14.82 4 345323 7177 63136518
Off label use 25.85 14.82 4110 341217 670352 62473343
Increased appetite 25.82 14.82 10 345317 9620 63134075
Disease recurrence 25.71 14.82 73 345254 27957 63115738
Post procedural haemorrhage 25.46 14.82 6 345321 7958 63135737
Joint space narrowing 25.44 14.82 23 345304 569 63143126
Acne 25.41 14.82 215 345112 23078 63120617
Toxic encephalopathy 25.35 14.82 3 345324 6576 63137119
Visual field defect 25.26 14.82 3 345324 6558 63137137
Anovulatory cycle 25.12 14.82 14 345313 154 63143541
Heavy menstrual bleeding 25.12 14.82 36 345291 17737 63125958
Erythema multiforme 24.98 14.82 12 345315 10157 63133538
Eye pain 24.97 14.82 97 345230 33757 63109938
Enterococcal infection 24.92 14.82 6 345321 7842 63135853
Cartilage atrophy 24.89 14.82 14 345313 157 63143538
Skin haemorrhage 24.66 14.82 12 345315 10082 63133613
Motor dysfunction 24.51 14.82 14 345313 10747 63132948
Fungal infection 24.50 14.82 110 345217 36764 63106931
Bedridden 24.48 14.82 122 345205 10929 63132766
Blood lactate dehydrogenase increased 24.45 14.82 56 345271 23060 63120635
Stevens-Johnson syndrome 24.37 14.82 63 345264 24887 63118808
Hypoacusis 24.35 14.82 60 345267 24091 63119604
Atrioventricular block first degree 24.22 14.82 5 345322 7268 63136427
Eyelid ptosis 24.19 14.82 5 345322 7262 63136433
Musculoskeletal chest pain 24.02 14.82 49 345278 21034 63122661
Face oedema 23.86 14.82 46 345281 20166 63123529
Electrocardiogram abnormal 23.85 14.82 10 345317 9169 63134526
Cerebral ischaemia 23.74 14.82 4 345323 6724 63136971
Drug-induced liver injury 23.62 14.82 328 344999 39894 63103801
Spinal meningioma benign 23.50 14.82 12 345315 109 63143586
Asphyxia 23.37 14.82 3 345324 6178 63137517
Crepitations 23.22 14.82 96 345231 7944 63135751
Haemorrhoids 23.15 14.82 54 345273 22096 63121599
Leukopenia 23.11 14.82 289 345038 77001 63066694
Rheumatoid lung 23.08 14.82 59 345268 3789 63139906
Influenza like illness 23.06 14.82 242 345085 66582 63077113
Aphonia 23.05 14.82 13 345314 10050 63133645
Urine output decreased 22.89 14.82 17 345310 11353 63132342
Pustular psoriasis 22.81 14.82 66 345261 4560 63139135
Mood altered 22.73 14.82 28 345299 14715 63128980
Myositis 22.66 14.82 11 345316 9255 63134440
Oral lichen planus 22.56 14.82 23 345304 663 63143032
Device failure 22.53 14.82 3 345324 6008 63137687
Injection site induration 22.49 14.82 11 345316 9215 63134480
Injection site warmth 22.25 14.82 30 345297 15165 63128530
Arthritis enteropathic 22.21 14.82 16 345311 283 63143412
Hyperthermia 22.19 14.82 11 345316 9145 63134550
Hyperreflexia 22.15 14.82 3 345324 5931 63137764
Pre-eclampsia 22.09 14.82 11 345316 9122 63134573
Sneezing 21.92 14.82 41 345286 18177 63125518
Vitamin D deficiency 21.83 14.82 26 345301 13866 63129829
Bipolar disorder 21.79 14.82 8 345319 7952 63135743
Cardiomegaly 21.76 14.82 39 345288 17575 63126120
Female genital tract fistula 21.72 14.82 7 345320 7552 63136143
Upper limb fracture 21.68 14.82 44 345283 18924 63124771
Intermenstrual bleeding 21.64 14.82 8 345319 7918 63135777
Drug level decreased 21.61 14.82 8 345319 7911 63135784
Illness 21.59 14.82 167 345160 48892 63094803
Enteritis 21.57 14.82 9 345318 8277 63135418
Needle issue 21.56 14.82 15 345312 10361 63133334
Hypovolaemic shock 21.39 14.82 4 345323 6237 63137458
Myocarditis 21.36 14.82 15 345312 10310 63133385
Thinking abnormal 21.32 14.82 16 345311 10627 63133068
Intestinal ischaemia 21.31 14.82 7 345320 7461 63136234
Tooth extraction 21.12 14.82 15 345312 10249 63133446
Unintended pregnancy 21.10 14.82 4 345323 6175 63137520
Synovial disorder 21.05 14.82 39 345288 2006 63141689
Menstruation irregular 21.01 14.82 6 345321 6998 63136697
Investigation abnormal 20.99 14.82 38 345289 1920 63141775
Granulocytopenia 20.86 14.82 3 345324 5669 63138026
Weber tuning fork test abnormal 20.81 14.82 11 345316 108 63143587
Breast pain 20.68 14.82 11 345316 8787 63134908
Weight fluctuation 20.67 14.82 14 345313 9805 63133890
Tooth fracture 20.63 14.82 18 345309 11092 63132603
Gingivitis 20.62 14.82 10 345317 8419 63135276
Thermal burn 20.46 14.82 4 345323 6042 63137653
Spinal fracture 20.36 14.82 43 345284 18228 63125467
Aortic valve incompetence 20.18 14.82 4 345323 5984 63137711
Staphylococcal bacteraemia 20.16 14.82 3 345324 5527 63138168
Clostridium difficile infection 20.04 14.82 89 345238 29833 63113862
Renal tubular necrosis 20.01 14.82 21 345306 11857 63131838
Bacterial infection 20.01 14.82 48 345279 19451 63124244
Exercise tolerance decreased 20.00 14.82 3 345324 5494 63138201
Squamous cell carcinoma 19.99 14.82 11 345316 8621 63135074
Bone disorder 19.96 14.82 55 345272 21271 63122424
Erysipelas 19.92 14.82 9 345318 7896 63135799
Anaphylactic shock 19.92 14.82 64 345263 23569 63120126
Cholecystitis acute 19.91 14.82 10 345317 8250 63135445
Drug reaction with eosinophilia and systemic symptoms 19.90 14.82 276 345051 33560 63110135
Amylase increased 19.85 14.82 5 345322 6340 63137355
Micturition urgency 19.83 14.82 14 345313 9597 63134098
Tendonitis 19.81 14.82 178 345149 19437 63124258
Appendicitis 19.77 14.82 10 345317 8219 63135476
Abortion induced 19.75 14.82 16 345311 10226 63133469
Decreased activity 19.74 14.82 5 345322 6315 63137380
Proctitis 19.73 14.82 3 345324 5438 63138257
Procedural complication 19.72 14.82 3 345324 5436 63138259
Concussion 19.70 14.82 13 345314 9231 63134464
Hypercapnia 19.68 14.82 3 345324 5428 63138267
Neck pain 19.63 14.82 505 344822 68813 63074882
Rash maculo-papular 19.52 14.82 98 345229 31798 63111897
Orthopnoea 19.46 14.82 5 345322 6256 63137439
Gait disturbance 19.40 14.82 1199 344128 181979 62961716
Hyperuricaemia 19.38 14.82 3 345324 5367 63138328
Nystagmus 19.27 14.82 5 345322 6215 63137480
Polyglandular disorder 19.25 14.82 7 345320 24 63143671
Aspergillus infection 19.20 14.82 10 345317 8083 63135612
Overlap syndrome 19.14 14.82 24 345303 872 63142823
Head discomfort 19.13 14.82 27 345300 13388 63130307
Hydrocephalus 19.04 14.82 3 345324 5297 63138398
Oral mucosal blistering 18.97 14.82 4 345323 5729 63137966
Mycobacterium marinum infection 18.94 14.82 14 345313 258 63143437
Psychomotor hyperactivity 18.94 14.82 18 345309 10645 63133050
Hydronephrosis 18.94 14.82 18 345309 10644 63133051
Short stature 18.92 14.82 21 345306 669 63143026
Major depression 18.89 14.82 10 345317 8008 63135687
Blood albumin decreased 18.87 14.82 32 345295 14734 63128961
Protein urine present 18.81 14.82 5 345322 6115 63137580
Normal newborn 18.78 14.82 11 345316 8330 63135365
Clear cell renal cell carcinoma 18.77 14.82 31 345296 1454 63142241
Maternal drugs affecting foetus 18.76 14.82 3 345324 5239 63138456
Metabolic disorder 18.73 14.82 6 345321 6497 63137198
Eye movement disorder 18.69 14.82 3 345324 5225 63138470
Immune reconstitution inflammatory syndrome 18.64 14.82 5 345322 6079 63137616
Glycosylated haemoglobin increased 18.64 14.82 24 345303 12374 63131321
Brain natriuretic peptide increased 18.62 14.82 3 345324 5210 63138485
Myopathy 18.61 14.82 20 345307 11171 63132524
Facial pain 18.56 14.82 18 345309 10543 63133152
Fear 18.51 14.82 36 345291 15730 63127965
Pneumonia viral 18.48 14.82 10 345317 7912 63135783
Injection site haematoma 18.48 14.82 7 345320 6825 63136870
Gastritis erosive 18.44 14.82 5 345322 6034 63137661
Paralysis 18.43 14.82 16 345311 9884 63133811
Infusion site pruritus 18.42 14.82 5 345322 6030 63137665
Burning sensation 18.38 14.82 198 345129 54209 63089486
Extrasystoles 18.36 14.82 3 345324 5157 63138538
Elbow deformity 18.31 14.82 31 345296 1484 63142211
Eyelid oedema 18.25 14.82 18 345309 10461 63133234
Antinuclear antibody positive 18.21 14.82 89 345238 7910 63135785
Tender joint count increased 18.18 14.82 8 345319 50 63143645
Injection site discolouration 18.18 14.82 10 345317 7838 63135857
Cardiac murmur 18.17 14.82 32 345295 14520 63129175
Low birth weight baby 18.15 14.82 8 345319 7121 63136574
Femoral neck fracture 18.14 14.82 12 345315 8511 63135184
Anti-neutrophil cytoplasmic antibody positive vasculitis 17.96 14.82 45 345282 2854 63140841
Juvenile idiopathic arthritis 17.92 14.82 49 345278 3277 63140418
Staphylococcal sepsis 17.91 14.82 11 345316 8117 63135578
Colitis microscopic 17.86 14.82 99 345228 9240 63134455
Granulomatous dermatitis 17.71 14.82 11 345316 150 63143545
Emphysema 17.69 14.82 20 345307 10918 63132777
C-reactive protein decreased 17.69 14.82 24 345303 943 63142752
Nail operation 17.69 14.82 23 345304 867 63142828
Viral upper respiratory tract infection 17.66 14.82 10 345317 7714 63135981
Pneumonia fungal 17.66 14.82 4 345323 5451 63138244
SARS-CoV-2 test positive 17.62 14.82 11 345316 8045 63135650
Bundle branch block right 17.57 14.82 3 345324 4995 63138700
Pneumothorax 17.52 14.82 39 345288 16222 63127473
Forced expiratory volume decreased 17.43 14.82 3 345324 4965 63138730
Tubulointerstitial nephritis 17.41 14.82 53 345274 19850 63123845
Neck mass 17.38 14.82 51 345276 3552 63140143
Pruritus allergic 17.34 14.82 31 345296 1551 63142144
Congestive cardiomyopathy 17.29 14.82 6 345321 6176 63137519
Expired product administered 17.28 14.82 6 345321 6175 63137520
Decubitus ulcer 17.28 14.82 19 345308 10501 63133194
Injection site rash 17.24 14.82 49 345278 18760 63124935
Food allergy 17.22 14.82 22 345305 11379 63132316
Demyelination 17.21 14.82 79 345248 6841 63136854
Escherichia urinary tract infection 17.13 14.82 24 345303 11938 63131757
Hypokinesia 17.09 14.82 31 345296 13905 63129790
Liver function test abnormal 17.02 14.82 362 344965 47819 63095876
Anticipatory anxiety 17.02 14.82 27 345300 1224 63142471
Ear discomfort 17.01 14.82 11 345316 7895 63135800
Salt craving 16.99 14.82 10 345317 123 63143572
Multiple fractures 16.91 14.82 92 345235 8526 63135169
Blood thyroid stimulating hormone increased 16.90 14.82 9 345318 7185 63136510
Adenoiditis 16.87 14.82 7 345320 37 63143658
Intervertebral disc disorder 16.83 14.82 3 345324 4840 63138855
Spondylitis 16.75 14.82 57 345270 4297 63139398
Effusion 16.74 14.82 32 345295 1686 63142009
Nail psoriasis 16.70 14.82 19 345308 622 63143073
Hypoaesthesia 16.68 14.82 747 344580 167646 62976049
Large intestine perforation 16.67 14.82 13 345314 8469 63135226
Gastrointestinal inflammation 16.48 14.82 5 345322 5607 63138088
Phlebitis 16.42 14.82 8 345319 6716 63136979
Precancerous cells present 16.40 14.82 29 345298 1438 63142257
Rotator cuff repair 16.36 14.82 36 345291 2098 63141597
Extrapulmonary tuberculosis 16.33 14.82 14 345313 322 63143373
Vitreous floaters 16.32 14.82 6 345321 5960 63137735
Blood culture positive 16.31 14.82 3 345324 4732 63138963
Deafness 16.30 14.82 47 345280 17910 63125785
Arterial occlusive disease 16.29 14.82 6 345321 5952 63137743
Stoma obstruction 16.25 14.82 10 345317 134 63143561
Spondyloarthropathy 16.21 14.82 22 345305 865 63142830
COVID-19 pneumonia 16.21 14.82 33 345294 14176 63129519
Toothache 16.17 14.82 52 345275 19147 63124548
Carotid artery occlusion 16.11 14.82 3 345324 4691 63139004
Neoplasm 16.10 14.82 10 345317 7335 63136360
Gastrointestinal motility disorder 16.08 14.82 4 345323 5115 63138580
Bladder disorder 16.01 14.82 15 345312 8931 63134764
Haemoglobin abnormal 15.94 14.82 4 345323 5084 63138611
Wound infection fungal 15.94 14.82 10 345317 139 63143556
White blood cell count increased 15.89 14.82 178 345149 48383 63095312
Atrial septal defect 15.84 14.82 9 345318 6929 63136766
Partial seizures 15.78 14.82 6 345321 5836 63137859
Laboratory test abnormal 15.73 14.82 84 345243 26828 63116867
Inflammatory pain 15.73 14.82 22 345305 890 63142805
Wound secretion 15.73 14.82 3 345324 4611 63139084
Ureterocele 15.66 14.82 5 345322 10 63143685
Rheumatoid factor quantitative increased 15.66 14.82 5 345322 10 63143685
Thoracic vertebral fracture 15.62 14.82 3 345324 4589 63139106
Injection site extravasation 15.62 14.82 15 345312 8826 63134869
Supraventricular extrasystoles 15.61 14.82 3 345324 4586 63139109
Cushingoid 15.60 14.82 89 345238 8396 63135299
Neurological symptom 15.52 14.82 6 345321 5777 63137918
Anosmia 15.52 14.82 9 345318 6851 63136844
Inflammatory marker increased 15.50 14.82 76 345251 6763 63136932
Drug resistance 15.49 14.82 68 345259 22865 63120830
Squamous cell carcinoma of skin 15.43 14.82 7 345320 6125 63137570
Taste disorder 15.35 14.82 32 345295 13630 63130065
Adrenal insufficiency 15.33 14.82 157 345170 17758 63125937
Pharyngitis 15.32 14.82 57 345270 20086 63123609
Increased tendency to bruise 15.28 14.82 21 345306 10531 63133164
Lymphoproliferative disorder 15.24 14.82 45 345282 3145 63140550
Pain in jaw 15.21 14.82 157 345170 43339 63100356
Left ventricular hypertrophy 15.14 14.82 5 345322 5310 63138385
Dry throat 15.12 14.82 9 345318 6756 63136939
Epigastric discomfort 15.12 14.82 75 345252 6705 63136990
Venous thrombosis 15.08 14.82 4 345323 4898 63138797
Euphoric mood 15.01 14.82 4 345323 4883 63138812
Stress at work 14.99 14.82 25 345302 1182 63142513
Oesophageal candidiasis 14.99 14.82 6 345321 5657 63138038
Injection site urticaria 14.96 14.82 34 345293 14039 63129656
Ear pain 14.95 14.82 125 345202 35993 63107702
Hyperkeratosis 14.94 14.82 7 345320 6011 63137684
HLA marker study positive 14.92 14.82 11 345316 202 63143493
Hypocalcaemia 14.89 14.82 106 345221 31607 63112088
Facial paralysis 14.86 14.82 34 345293 14007 63129688

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 1931.82 14.31 2955 53413 453796 34446767
Drug intolerance 1290.46 14.31 933 55435 58637 34841926
Joint swelling 1283.69 14.31 932 55436 58958 34841605
Synovitis 930.77 14.31 454 55914 13612 34886951
Contraindicated product administered 734.97 14.31 448 55920 21033 34879530
Treatment failure 653.14 14.31 566 55802 46131 34854432
Musculoskeletal stiffness 619.13 14.31 549 55819 46131 34854432
Apparent death 605.13 14.31 226 56142 3418 34897145
Arthropathy 584.93 14.31 423 55945 26484 34874079
C-reactive protein abnormal 581.59 14.31 283 56085 8427 34892136
Pain 579.20 14.31 1116 55252 203559 34697004
Rheumatoid arthritis 549.81 14.31 471 55897 37767 34862796
Psoriatic arthropathy 532.96 14.31 355 56013 19443 34881120
Therapeutic product effect decreased 520.05 14.31 438 55930 34305 34866258
Arthralgia 465.53 14.31 915 55453 169126 34731437
C-reactive protein increased 440.87 14.31 488 55880 53610 34846953
Diverticulitis 424.43 14.31 310 56058 19694 34880869
Hand deformity 407.90 14.31 171 56197 3554 34897009
Loss of personal independence in daily activities 356.03 14.31 347 56021 32832 34867731
Red blood cell sedimentation rate increased 346.65 14.31 204 56164 8958 34891605
Drug hypersensitivity 331.28 14.31 519 55849 80010 34820553
Mobility decreased 266.54 14.31 284 56084 29844 34870719
Arthritis 264.19 14.31 288 56080 31058 34869505
Death 232.36 14.31 182 56186 397867 34502696
Enthesopathy 215.70 14.31 118 56250 4495 34896068
Toxicity to various agents 213.28 14.31 34 56334 200328 34700235
Impaired work ability 212.68 14.31 135 56233 6795 34893768
Therapeutic product effect incomplete 199.68 14.31 320 56048 50221 34850342
Acute kidney injury 196.78 14.31 125 56243 304863 34595700
Lymphoma 195.88 14.31 162 56206 12345 34888218
Pulmonary thrombosis 185.29 14.31 127 56241 7280 34893283
Red blood cell sedimentation rate abnormal 182.31 14.31 97 56271 3492 34897071
Inflammation 181.53 14.31 226 56142 28069 34872494
Knee arthroplasty 173.01 14.31 122 56246 7322 34893241
Hypotension 172.39 14.31 71 56297 221578 34678985
Tenosynovitis 165.63 14.31 99 56269 4471 34896092
Bone erosion 164.04 14.31 94 56274 3921 34896642
Drug interaction 162.26 14.31 81 56287 225865 34674698
Ankylosing spondylitis 156.76 14.31 103 56265 5501 34895062
Drug tolerance decreased 156.03 14.31 72 56296 1895 34898668
Terminal state 152.47 14.31 89 56279 3845 34896718
Onychoclasis 149.00 14.31 69 56299 1831 34898732
Febrile neutropenia 148.30 14.31 22 56346 136827 34763736
Joint range of motion decreased 143.07 14.31 108 56260 7204 34893359
Psoriasis 140.10 14.31 236 56132 38576 34861987
Anaemia 137.90 14.31 105 56263 233230 34667333
Deep vein thrombosis 134.93 14.31 314 56054 64934 34835629
Alanine aminotransferase abnormal 130.73 14.31 86 56282 4602 34895961
Completed suicide 123.69 14.31 9 56359 98159 34802404
Gastrointestinal disorder 120.62 14.31 205 56163 33743 34866820
Joint arthroplasty 114.90 14.31 46 56322 845 34899718
Polyarthritis 113.91 14.31 78 56290 4462 34896101
Pulmonary fibrosis 113.29 14.31 144 56224 18252 34882311
Malignant neoplasm progression 111.12 14.31 8 56360 88038 34812525
Dehydration 110.43 14.31 36 56332 129933 34770630
Tooth loss 105.70 14.31 70 56298 3788 34896775
Rheumatoid factor positive 103.69 14.31 40 56328 663 34899900
Tongue disorder 102.56 14.31 78 56290 5261 34895302
Gastric disorder 102.47 14.31 113 56255 12328 34888235
Herpes zoster 102.04 14.31 192 56176 34207 34866356
Confusional state 101.39 14.31 53 56315 144107 34756456
Swelling 100.01 14.31 215 56153 42151 34858412
Joint stiffness 98.75 14.31 104 56264 10769 34889794
Osteoarthritis 97.39 14.31 142 56226 20500 34880063
Grip strength decreased 92.93 14.31 60 56308 3109 34897454
Condition aggravated 91.56 14.31 576 55792 191620 34708943
Intestinal sepsis 91.26 14.31 36 56332 635 34899928
Tendonitis 89.45 14.31 91 56277 9049 34891514
Musculoskeletal pain 89.38 14.31 174 56194 31789 34868774
Photosensitivity reaction 88.59 14.31 97 56271 10497 34890066
Sleep disorder due to general medical condition, insomnia type 88.52 14.31 43 56325 1273 34899290
Hyperkalaemia 88.44 14.31 6 56362 69383 34831180
Nodule 87.82 14.31 79 56289 6740 34893823
Pain in extremity 86.26 14.31 418 55950 126095 34774468
Musculoskeletal discomfort 85.73 14.31 84 56284 7984 34892579
Bradycardia 84.29 14.31 11 56357 75407 34825156
Anti-cyclic citrullinated peptide antibody positive 83.00 14.31 46 56322 1797 34898766
Limb discomfort 81.89 14.31 95 56273 10952 34889611
Dyspnoea 81.21 14.31 323 56045 376459 34524104
Atrial fibrillation 80.29 14.31 49 56319 122344 34778219
Impaired quality of life 80.10 14.31 70 56298 5748 34894815
Colitis ulcerative 79.90 14.31 115 56253 16405 34884158
Thrombocytopenia 79.29 14.31 81 56287 156166 34744397
Alopecia 78.60 14.31 141 56227 24214 34876349
Uveitis 77.37 14.31 77 56291 7458 34893105
Hip arthroplasty 76.40 14.31 61 56307 4418 34896145
Intentional product use issue 76.33 14.31 241 56127 59575 34840988
Seronegative arthritis 76.12 14.31 36 56332 1003 34899560
Arthritis bacterial 75.51 14.31 64 56304 5042 34895521
Interstitial lung disease 74.31 14.31 253 56115 65029 34835534
Pulmonary embolism 71.88 14.31 311 56057 89435 34811128
Decreased appetite 71.86 14.31 98 56270 166294 34734269
Foot deformity 71.50 14.31 59 56309 4478 34896085
Rhabdomyolysis 71.42 14.31 12 56356 68151 34832412
Disability 71.02 14.31 60 56308 4705 34895858
Cytology abnormal 70.70 14.31 26 56342 375 34900188
Localised infection 70.26 14.31 112 56256 17475 34883088
Joint ankylosis 70.15 14.31 39 56329 1533 34899030
Bladder transitional cell carcinoma 69.91 14.31 47 56321 2608 34897955
Liver function test increased 69.87 14.31 101 56267 14464 34886099
Hypokalaemia 68.77 14.31 7 56361 58207 34842356
Steroid dependence 68.69 14.31 38 56330 1479 34899084
Rheumatoid nodule 67.78 14.31 48 56320 2899 34897664
Dactylitis 67.71 14.31 32 56336 890 34899673
Constipation 67.25 14.31 73 56295 136909 34763654
Disease progression 67.15 14.31 46 56322 108031 34792532
Axial spondyloarthritis 66.44 14.31 24 56344 328 34900235
Cardiac arrest 65.16 14.31 37 56331 96122 34804441
Blood creatinine increased 65.15 14.31 36 56332 94940 34805623
Dizziness 64.80 14.31 162 56206 218359 34682204
Seizure 64.65 14.31 45 56323 104812 34795751
Frequent bowel movements 63.29 14.31 90 56278 12697 34887866
Infection 63.08 14.31 302 56066 90613 34809950
Hyponatraemia 61.74 14.31 28 56340 82663 34817900
Immobile 60.57 14.31 42 56326 2452 34898111
Overdose 57.57 14.31 38 56330 91021 34809542
Somnolence 57.03 14.31 57 56311 111059 34789504
Soft tissue swelling 55.80 14.31 24 56344 532 34900031
Neoplasm malignant 55.19 14.31 108 56260 19797 34880766
Cardio-respiratory arrest 55.17 14.31 11 56357 55262 34845301
International normalised ratio increased 55.10 14.31 6 56362 47321 34853242
Peripheral swelling 55.08 14.31 257 56111 76284 34824279
Hepatic enzyme abnormal 54.43 14.31 41 56327 2725 34897838
Food intolerance 54.40 14.31 32 56336 1402 34899161
Agitation 54.10 14.31 13 56355 57386 34843177
Vomiting 53.39 14.31 212 56156 247409 34653154
Hypoxia 52.87 14.31 12 56356 55083 34845480
Joint effusion 51.35 14.31 52 56316 5141 34895422
Asthenia 50.97 14.31 213 56155 245038 34655525
Electrocardiogram QT prolonged 50.85 14.31 4 56364 40948 34859615
Rheumatoid factor negative 50.51 14.31 26 56342 873 34899690
Hallucination 49.85 14.31 11 56357 51487 34849076
Abdominal pain 49.48 14.31 120 56248 163498 34737065
Platelet count decreased 48.22 14.31 74 56294 119643 34780920
Neutropenia 48.18 14.31 114 56254 156664 34743899
Hypoglycaemia 46.60 14.31 15 56353 54625 34845938
Fibromyalgia 46.13 14.31 39 56329 3061 34897502
Liver disorder 45.84 14.31 137 56231 32860 34867703
X-ray abnormal 45.78 14.31 20 56348 461 34900102
Suicide attempt 45.43 14.31 5 56363 39111 34861452
Renal impairment 44.58 14.31 52 56316 94461 34806102
Oedema peripheral 44.57 14.31 78 56290 119734 34780829
Lactic acidosis 44.31 14.31 3 56365 34769 34865794
Bone cyst 43.75 14.31 29 56339 1571 34898992
Red blood cell sedimentation rate 43.73 14.31 26 56342 1162 34899401
Prerenal failure 43.49 14.31 32 56336 2052 34898511
Tuberculosis 43.37 14.31 61 56307 8516 34892047
Arthrodesis 43.29 14.31 19 56349 443 34900120
Multiple organ dysfunction syndrome 43.16 14.31 36 56332 76530 34824033
Metabolic acidosis 42.95 14.31 9 56359 43671 34856892
Hospitalisation 42.88 14.31 19 56349 56883 34843680
Respiratory distress 42.87 14.31 4 56364 35661 34864902
Septic shock 42.73 14.31 32 56336 71802 34828761
Granuloma skin 41.96 14.31 26 56342 1253 34899310
Limb deformity 41.80 14.31 20 56348 572 34899991
Blood glucose increased 40.62 14.31 29 56339 66689 34833874
Pulmonary tuberculosis 40.56 14.31 44 56324 4710 34895853
Syncope 40.31 14.31 53 56315 91398 34809165
Bronchiectasis 39.94 14.31 63 56305 9738 34890825
Coma 39.92 14.31 12 56356 45666 34854897
Mental status changes 39.23 14.31 7 56361 38076 34862487
Off label use 38.96 14.31 917 55451 418607 34481956
Blood creatine phosphokinase increased 38.81 14.31 12 56356 44845 34855718
Intervertebral disc annular tear 38.39 14.31 9 56359 20 34900543
Hepatic fibrosis 38.20 14.31 42 56326 4565 34895998
Dyspepsia 38.01 14.31 138 56230 36594 34863969
Panniculitis 38.00 14.31 29 56339 1965 34898598
Pyrexia 37.92 14.31 349 56019 332664 34567899
Delirium 37.64 14.31 12 56356 43979 34856584
Pulmonary toxicity 37.64 14.31 48 56320 6099 34894464
Tenderness 37.59 14.31 51 56317 6883 34893680
Respiratory failure 37.44 14.31 74 56294 108498 34792065
Diarrhoea 36.88 14.31 427 55941 389485 34511078
Oligoarthritis 36.25 14.31 12 56356 124 34900439
Blood pressure fluctuation 36.18 14.31 106 56262 25143 34875420
Abdominal distension 36.17 14.31 25 56343 58467 34842096
Blood parathyroid hormone decreased 36.12 14.31 25 56343 1455 34899108
White blood cell count decreased 35.61 14.31 62 56306 95383 34805180
Muscular weakness 35.57 14.31 39 56329 72858 34827705
Cerebrovascular accident 35.52 14.31 51 56317 84760 34815803
Enzyme abnormality 35.18 14.31 14 56354 253 34900310
Plasma cell myeloma 35.04 14.31 12 56356 42025 34858538
Lymphadenopathy 34.75 14.31 113 56255 28350 34872213
Fall 34.62 14.31 189 56179 202696 34697867
Gastrointestinal haemorrhage 34.37 14.31 56 56312 88421 34812142
Iritis 34.37 14.31 24 56344 1417 34899146
Pneumonia 34.32 14.31 397 55971 362230 34538333
Drug reaction with eosinophilia and systemic symptoms 34.13 14.31 124 56244 32888 34867675
Urticaria 34.09 14.31 194 56174 62183 34838380
Ill-defined disorder 33.27 14.31 71 56297 13838 34886725
Hepatic cirrhosis 33.22 14.31 81 56287 17233 34883330
Ankle deformity 33.02 14.31 13 56355 228 34900335
Depressed level of consciousness 32.76 14.31 14 56354 42827 34857736
Aggression 32.69 14.31 11 56357 38953 34861610
Angioedema 32.33 14.31 10 56358 37364 34863199
Osteolysis 32 14.31 32 56336 3116 34897447
Fine motor skill dysfunction 31.72 14.31 25 56343 1777 34898786
Loss of consciousness 31.48 14.31 53 56315 82614 34817949
Neutrophil count decreased 31.38 14.31 22 56346 51082 34849481
Neck pain 31.27 14.31 101 56267 25248 34875315
Thrombosis 30.99 14.31 162 56206 50296 34850267
Epistaxis 30.89 14.31 29 56339 58222 34842341
Cerebral haemorrhage 30.85 14.31 9 56359 34928 34865635
Cardiac failure 30.76 14.31 63 56305 91185 34809378
Abdominal discomfort 30.69 14.31 183 56185 59652 34840911
Gait inability 30.56 14.31 88 56280 20670 34879893
Rheumatoid lung 30.52 14.31 19 56349 923 34899640
Haemorrhage 30.40 14.31 23 56345 51347 34849216
Abscess 30.22 14.31 62 56306 11755 34888808
Skin injury 29.86 14.31 27 56341 2318 34898245
Dysphagia 29.75 14.31 34 56334 62347 34838216
Xyphoid retraction 29.70 14.31 11 56357 162 34900401
Cardiogenic shock 29.44 14.31 4 56364 26614 34873949
Hyperhidrosis 29.31 14.31 48 56320 75644 34824919
Tuberculin test positive 29.16 14.31 20 56348 1147 34899416
Exostosis 29.11 14.31 37 56331 4686 34895877
Sacroiliitis 29.02 14.31 22 56346 1476 34899087
Atrial septal defect acquired 28.87 14.31 7 56361 19 34900544
Intentional product misuse 28.86 14.31 19 56349 45592 34854971
Haematemesis 28.75 14.31 5 56363 27706 34872857
Pneumonia aspiration 28.54 14.31 16 56352 41887 34858676
Therapeutic response decreased 28.54 14.31 108 56260 29205 34871358
Blood bilirubin increased 28.52 14.31 13 56355 38283 34862280
Erythema 28.29 14.31 242 56126 88538 34812025
Thrombocytosis 28.22 14.31 34 56334 4078 34896485
Rash vesicular 27.81 14.31 28 56340 2749 34897814
Systemic lupus erythematosus 27.55 14.31 32 56336 3692 34896871
Sensitivity to weather change 27.42 14.31 22 56346 1604 34898959
Lymphoedema 27.31 14.31 33 56335 3970 34896593
Wrong technique in product usage process 27.13 14.31 12 56356 35974 34864589
Stent placement 27 14.31 37 56331 5041 34895522
Inappropriate schedule of product administration 26.68 14.31 182 56186 62114 34838449
Inflammatory bowel disease 26.63 14.31 28 56340 2892 34897671
Dysstasia 26.61 14.31 60 56308 12135 34888428
Chronic kidney disease 26.30 14.31 17 56351 41193 34859370
Nasopharyngitis 26.25 14.31 198 56170 69770 34830793
Cognitive disorder 26.06 14.31 7 56361 28686 34871877
Neck mass 25.47 14.31 21 56347 1592 34898971
Hepatic failure 25.28 14.31 12 56356 34519 34866044
Shoulder operation 25.11 14.31 18 56350 1108 34899455
Splenic embolism 24.71 14.31 10 56358 189 34900374
Wrist deformity 24.65 14.31 12 56356 357 34900206
Medium-chain acyl-coenzyme A dehydrogenase deficiency 24.61 14.31 7 56361 41 34900522
Transient ischaemic attack 24.59 14.31 7 56361 27606 34872957
Fragile X syndrome 24.47 14.31 7 56361 42 34900521
Feeding disorder 24.44 14.31 42 56326 6968 34893595
Urinary tract infection 24.34 14.31 63 56305 84018 34816545
Muscle spasms 24.26 14.31 53 56315 74948 34825615
Nail bed bleeding 24.22 14.31 12 56356 371 34900192
Fear of injection 24.07 14.31 20 56348 1532 34899031
Cutaneous symptom 23.99 14.31 11 56357 285 34900278
Memory impairment 23.63 14.31 21 56347 43297 34857266
Restlessness 23.56 14.31 6 56362 25476 34875087
Oesophageal infection 23.54 14.31 11 56357 298 34900265
Inflammatory pain 23.44 14.31 10 56358 217 34900346
Maternal exposure during pregnancy 23.43 14.31 34 56334 4884 34895679
Blood urea increased 23.09 14.31 10 56358 30354 34870209
Basal cell carcinoma 23.06 14.31 77 56291 19581 34880982
Haemoptysis 22.94 14.31 14 56354 34992 34865571
Drug level increased 22.89 14.31 4 56364 22092 34878471
Anxiety 22.74 14.31 83 56285 99345 34801218
Ascites 22.62 14.31 25 56343 46546 34854017
Renal failure 22.56 14.31 315 56053 130242 34770321
Hepatic steatosis 22.50 14.31 73 56295 18289 34882274
Aortic bruit 22.40 14.31 10 56358 243 34900320
Sideroblastic anaemia 22.18 14.31 10 56358 249 34900314
Disorientation 22.14 14.31 13 56355 33175 34867388
Epilepsy 22.03 14.31 4 56364 21491 34879072
Swollen joint count increased 21.99 14.31 10 56358 254 34900309
Encephalopathy 21.96 14.31 15 56353 35304 34865259
Acute myocardial infarction 21.80 14.31 33 56335 53686 34846877
Hyperglycaemia 21.71 14.31 19 56349 39461 34861102
Ossicle disorder 21.57 14.31 6 56362 32 34900531
Feeling abnormal 21.54 14.31 175 56193 63060 34837503
Blood pressure decreased 21.54 14.31 31 56337 51484 34849079
Trisomy 8 21.44 14.31 7 56361 69 34900494
Muscle strain 21.18 14.31 29 56339 3947 34896616
Haematuria 21.06 14.31 30 56338 50036 34850527
Diaphragmatic injury 20.99 14.31 8 56360 128 34900435
Skin ulcer 20.93 14.31 81 56287 22135 34878428
Lymphoproliferative disorder 20.90 14.31 24 56344 2735 34897828
Granuloma 20.88 14.31 26 56342 3225 34897338
Elbow operation 20.82 14.31 8 56360 131 34900432
Cryopyrin associated periodic syndrome 20.75 14.31 7 56361 77 34900486
Bone tuberculosis 20.67 14.31 11 56357 396 34900167
Dermatitis psoriasiform 20.59 14.31 18 56350 1478 34899085
Microcephaly 20.50 14.31 14 56354 797 34899766
Urinary incontinence 20.49 14.31 3 56365 18871 34881692
Wheezing 20.36 14.31 22 56346 41380 34859183
Mycobacterium tuberculosis complex test positive 20.32 14.31 17 56351 1315 34899248
Pancreatitis acute 20.26 14.31 10 56358 28131 34872432
Ventricular fibrillation 20.11 14.31 6 56362 22948 34877615
Tendon disorder 20.10 14.31 24 56344 2851 34897712
Anti-saccharomyces cerevisiae antibody 20.01 14.31 5 56363 16 34900547
Diffuse idiopathic skeletal hyperostosis 19.71 14.31 6 56362 46 34900517
Hepatic enzyme increased 19.70 14.31 119 56249 38961 34861602
Vitamin B1 decreased 19.64 14.31 10 56358 328 34900235
Generalised tonic-clonic seizure 19.55 14.31 5 56363 21169 34879394
Melaena 19.48 14.31 17 56351 35363 34865200
Intestinal diaphragm disease 19.39 14.31 9 56359 240 34900323
Skin laceration 19.36 14.31 54 56314 12455 34888108
Oral pustule 19.32 14.31 9 56359 242 34900321
Osteonecrosis of jaw 19.06 14.31 3 56365 17886 34882677
Orthostatic hypotension 18.98 14.31 9 56359 25910 34874653
Vision blurred 18.88 14.31 28 56340 45935 34854628
Pancytopenia 18.87 14.31 84 56284 95073 34805490
Neoplasm progression 18.82 14.31 7 56361 23293 34877270
Cholestasis 18.77 14.31 10 56358 26938 34873625
Stomatitis 18.67 14.31 125 56243 42389 34858174
Acute lung injury 18.47 14.31 17 56351 1493 34899070
Carbon dioxide abnormal 18.41 14.31 8 56360 182 34900381
Hepatic function abnormal 18.25 14.31 27 56341 44336 34856227
Mantle cell lymphoma stage III 18.24 14.31 5 56363 25 34900538
Lacrimal duct neoplasm 18.24 14.31 5 56363 25 34900538
Full blood count abnormal 18.04 14.31 4 56364 18664 34881899
Joint space narrowing 17.97 14.31 8 56360 193 34900370
Pulmonary mass 17.60 14.31 53 56315 12759 34887804
Back pain 17.59 14.31 285 56083 121504 34779059
Tender joint count increased 17.53 14.31 8 56360 205 34900358
Degenerative bone disease 17.47 14.31 6 56362 70 34900493
Coronary artery disease 17.44 14.31 32 56336 48273 34852290
Inflammatory marker increased 17.36 14.31 30 56338 4998 34895565
Tachycardia 17.32 14.31 74 56294 84698 34815865
C-reactive protein 17.31 14.31 7 56361 132 34900431
Contraindication to medical treatment 17.31 14.31 12 56356 700 34899863
Respiratory arrest 17.31 14.31 12 56356 28031 34872532
Suicidal ideation 17.18 14.31 24 56344 40364 34860199
Psychotic disorder 17.14 14.31 9 56359 24443 34876120
Synovial cyst 17.10 14.31 20 56348 2324 34898239
Post infection glomerulonephritis 17.02 14.31 6 56362 76 34900487
Stress 16.98 14.31 95 56273 30252 34870311
Alanine aminotransferase increased 16.90 14.31 202 56166 80613 34819950
Spondylitis 16.84 14.31 15 56353 1263 34899300
Hallucination, visual 16.81 14.31 4 56364 17787 34882776
Subdural haematoma 16.72 14.31 6 56362 20415 34880148
Respiratory depression 16.70 14.31 3 56365 16242 34884321
Mixed connective tissue disease 16.70 14.31 5 56363 36 34900527
Joint injury 16.63 14.31 42 56326 9131 34891432
Finger deformity 16.53 14.31 16 56352 1497 34899066
Chest discomfort 16.44 14.31 40 56328 54490 34846073
Dyspnoea exertional 16.23 14.31 28 56340 43251 34857312
Myalgia 16.23 14.31 75 56293 84035 34816528
Treatment noncompliance 16.09 14.31 13 56355 28087 34872476
Anaphylactic reaction 16.06 14.31 17 56351 32284 34868279
Drug withdrawal syndrome 15.95 14.31 6 56362 19828 34880735
Epstein Barr virus positive mucocutaneous ulcer 15.86 14.31 9 56359 368 34900195
Granulomatous dermatitis 15.75 14.31 8 56360 261 34900302
Nephrolithiasis 15.69 14.31 93 56275 30240 34870323
Physical disability 15.68 14.31 15 56353 1384 34899179
Joint destruction 15.67 14.31 9 56359 377 34900186
Ischaemic stroke 15.57 14.31 5 56363 18245 34882318
Injury 15.43 14.31 7 56361 20680 34879883
Urinary retention 15.01 14.31 22 56346 36266 34864297
Labelled drug-drug interaction medication error 14.84 14.31 3 56365 14936 34885627
Headache 14.84 14.31 426 55942 200209 34700354
Product administration error 14.82 14.31 4 56364 16340 34884223
Enanthema 14.80 14.31 9 56359 419 34900144
Ankle fracture 14.76 14.31 25 56343 4100 34896463
Spinal cord oedema 14.73 14.31 7 56361 197 34900366
Sitting disability 14.73 14.31 7 56361 197 34900366
Clostridium difficile infection 14.73 14.31 6 56362 18892 34881671
Incorrect route of product administration 14.71 14.31 3 56365 14842 34885721
Product dose omission issue 14.64 14.31 123 56245 119588 34780975
Acute respiratory failure 14.59 14.31 17 56351 30911 34869652
Sinus tachycardia 14.39 14.31 5 56363 17355 34883208
Ventricular tachycardia 14.36 14.31 13 56355 26566 34873997

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug intolerance 4998.56 13.95 5542 295319 258577 79184950
Drug ineffective 4479.77 13.95 11392 289469 1069521 78374006
Joint swelling 3489.14 13.95 4838 296023 283808 79159719
Synovitis 3384.86 13.95 3468 297393 147266 79296261
Contraindicated product administered 3339.06 13.95 3514 297347 154024 79289503
Treatment failure 3018.09 13.95 3460 297401 167026 79276501
Arthropathy 2411.20 13.95 3149 297712 173962 79269565
Therapeutic product effect decreased 2348.80 13.95 2989 297872 160874 79282653
Hand deformity 1942.03 13.95 2171 298690 101748 79341779
Systemic lupus erythematosus 1893.74 13.95 2309 298552 118840 79324687
Pemphigus 1837.81 13.95 2067 298794 97515 79346012
Musculoskeletal stiffness 1653.61 13.95 2617 298244 172391 79271136
Glossodynia 1591.06 13.95 1955 298906 101382 79342145
Anti-cyclic citrullinated peptide antibody positive 1563.30 13.95 1743 299118 81400 79362127
Abdominal discomfort 1530.92 13.95 3098 297763 247629 79195898
C-reactive protein abnormal 1444.96 13.95 1304 299557 47063 79396464
Drug hypersensitivity 1398.34 13.95 3318 297543 295598 79147929
Swelling 1392.48 13.95 2736 298125 213975 79229552
Arthralgia 1376.31 13.95 5003 295858 566800 78876727
Pain 1359.39 13.95 5744 295117 698058 78745469
Alopecia 1340.40 13.95 2798 298063 228557 79214970
Rheumatoid factor positive 1328.17 13.95 1370 299491 58469 79385058
Pericarditis 1291.97 13.95 1772 299089 102464 79341063
Death 1230.53 13.95 312 300549 566202 78877325
Hepatic enzyme increased 1224.54 13.95 2348 298513 180262 79263265
Psoriatic arthropathy 1194.30 13.95 1472 299389 76527 79367000
Rheumatoid arthritis 1189.47 13.95 2506 298355 205964 79237563
Wound 1164.29 13.95 1786 299075 114393 79329134
Acute kidney injury 1103.08 13.95 299 300562 519105 78924422
Hypersensitivity 1074.39 13.95 2768 298093 259471 79184056
Therapeutic product effect incomplete 1007.13 13.95 1868 298993 139777 79303750
Discomfort 1003.53 13.95 1743 299118 123874 79319653
Loss of personal independence in daily activities 1001.12 13.95 1558 299303 101022 79342505
Duodenal ulcer perforation 964.62 13.95 1219 299642 64992 79378535
C-reactive protein increased 946.72 13.95 1725 299136 127302 79316225
Helicobacter infection 928.96 13.95 1228 299633 68476 79375051
Red blood cell sedimentation rate increased 899.07 13.95 984 299877 44958 79398569
Toxicity to various agents 893.90 13.95 243 300618 421297 79022230
Completed suicide 851.76 13.95 15 300846 245752 79197775
Sleep disorder due to general medical condition, insomnia type 821.37 13.95 915 299946 42641 79400886
Anaemia 813.51 13.95 331 300530 444684 78998843
Red blood cell sedimentation rate abnormal 803.01 13.95 652 300209 20311 79423216
Hypotension 799.22 13.95 331 300530 439986 79003541
Infusion related reaction 795.08 13.95 2283 298578 227954 79215573
Drug interaction 790.00 13.95 290 300571 414893 79028634
Condition aggravated 722.89 13.95 3762 297099 497362 78946165
Mobility decreased 660.59 13.95 1438 299423 120737 79322790
Peripheral swelling 635.42 13.95 2347 298514 267270 79176257
Febrile neutropenia 623.55 13.95 71 300790 230928 79212599
Product use issue 608.14 13.95 1957 298904 207865 79235662
Irritable bowel syndrome 596.70 13.95 938 299923 61303 79382224
Muscle injury 595.79 13.95 822 300039 47739 79395788
Bone erosion 592.31 13.95 511 300350 17336 79426191
Folliculitis 587.84 13.95 875 299986 54505 79389022
Drug abuse 576.10 13.95 7 300854 162684 79280843
Dehydration 564.80 13.95 123 300738 248064 79195463
Maternal exposure during pregnancy 559.94 13.95 1443 299418 135095 79308432
Thrombocytopenia 559.75 13.95 154 300707 265105 79178422
Infection 558.43 13.95 2091 298770 239621 79203906
Inflammation 543.03 13.95 1135 299726 92618 79350909
Constipation 539.18 13.95 197 300664 282853 79160674
Osteoarthritis 535.16 13.95 1082 299779 86227 79357300
Rash 511.37 13.95 3830 297031 574528 78868999
Gastrointestinal disorder 495.33 13.95 1286 299575 120919 79322608
Knee arthroplasty 488.91 13.95 704 300157 42544 79400983
Arthritis 486.40 13.95 1229 299632 113651 79329876
Impaired healing 477.39 13.95 1035 299826 86620 79356907
Blister 465.58 13.95 1239 299622 118237 79325290
Cardiac arrest 461.58 13.95 54 300807 172042 79271485
Atrial fibrillation 440.26 13.95 103 300758 197783 79245744
Malignant neoplasm progression 438.55 13.95 17 300844 135973 79307554
Hip arthroplasty 432.19 13.95 601 300260 35155 79408372
Seizure 426.66 13.95 95 300766 188739 79254788
Neutropenia 423.11 13.95 283 300578 287427 79156100
Hyponatraemia 419.31 13.95 81 300780 177767 79265760
Grip strength decreased 416.62 13.95 462 300399 21407 79422120
Rheumatoid nodule 411.66 13.95 413 300448 17025 79426502
Dyspnoea 395.03 13.95 1779 299082 855246 78588281
Somnolence 392.31 13.95 206 300655 238775 79204752
Fall 391.45 13.95 781 300080 486848 78956679
Fibromyalgia 386.65 13.95 791 300070 63549 79379978
Bradycardia 382.94 13.95 35 300826 135522 79308005
Hyperkalaemia 380.53 13.95 11 300850 114387 79329140
Disability 379.62 13.95 392 300469 16728 79426799
Ill-defined disorder 368.00 13.95 786 300075 65089 79378438
Respiratory failure 352.74 13.95 121 300740 180790 79262737
Rheumatic fever 351.54 13.95 484 300377 28041 79415486
Disease progression 348.06 13.95 130 300731 184232 79259295
Cardio-respiratory arrest 345.05 13.95 15 300846 108495 79335032
Drug tolerance decreased 343.03 13.95 327 300534 12651 79430876
Platelet count decreased 331.15 13.95 160 300701 194504 79249023
Swollen joint count increased 319.32 13.95 413 300448 22514 79421013
Tremor 319.28 13.95 121 300740 169962 79273565
Blood parathyroid hormone decreased 310.37 13.95 282 300579 10254 79433273
Cardiac failure 309.85 13.95 99 300762 154743 79288784
Rhabdomyolysis 307.01 13.95 21 300840 103110 79340417
Granuloma skin 303.03 13.95 262 300599 8912 79434615
Cardiac failure congestive 301.46 13.95 82 300779 142320 79301207
Ankylosing spondylitis 300.92 13.95 296 300565 11909 79431618
Joint stiffness 296.67 13.95 544 300317 40286 79403241
Joint range of motion decreased 294.82 13.95 484 300377 32798 79410729
Overdose 294.63 13.95 164 300697 184042 79259485
Asthenia 290.33 13.95 976 299885 510713 78932814
Hypoglycaemia 287.55 13.95 26 300835 101568 79341959
Enthesopathy 287.08 13.95 282 300579 11326 79432201
Adverse event 286.49 13.95 674 300187 59540 79383987
Gastrointestinal haemorrhage 285.87 13.95 100 300761 147619 79295908
Panniculitis 284.69 13.95 289 300572 12082 79431445
Depressed level of consciousness 283.90 13.95 21 300840 96631 79346896
Tachycardia 283.26 13.95 159 300702 177609 79265918
Musculoskeletal pain 280.25 13.95 937 299924 101417 79342110
Blood cholesterol increased 277.61 13.95 819 300042 82901 79360626
Stomatitis 274.07 13.95 1189 299672 145568 79297959
Electrocardiogram QT prolonged 273.21 13.95 17 300844 90369 79353158
Product dose omission issue 272.88 13.95 319 300542 247218 79196309
Multiple organ dysfunction syndrome 264.58 13.95 64 300797 120182 79323345
Lower respiratory tract infection 263.93 13.95 1076 299785 128144 79315383
Tenosynovitis 263.10 13.95 309 300552 15245 79428282
Hypoxia 260.97 13.95 39 300822 103204 79340323
Cerebrovascular accident 254.54 13.95 134 300727 155158 79288369
Hypokalaemia 247.06 13.95 117 300744 143923 79299604
International normalised ratio increased 244.36 13.95 20 300841 84701 79358826
Polyarthritis 243.20 13.95 264 300597 11938 79431589
Syncope 240.95 13.95 194 300667 179255 79264272
Suicide attempt 235.30 13.95 21 300840 82911 79360616
Metabolic acidosis 233.88 13.95 21 300840 82508 79361019
Lactic acidosis 233.11 13.95 7 300854 70352 79373175
Intentional product use issue 232.21 13.95 1162 299699 150950 79292577
Anxiety 230.69 13.95 363 300498 248149 79195378
Coma 230.58 13.95 49 300812 100600 79342927
Agitation 229.56 13.95 48 300813 99667 79343860
Deformity 229.49 13.95 229 300632 9376 79434151
Foot deformity 225.34 13.95 359 300502 23715 79419812
Sepsis 224.99 13.95 421 300440 269007 79174520
Nasopharyngitis 223.77 13.95 1682 299179 252199 79191328
Joint destruction 222.05 13.95 182 300679 5743 79437784
Diarrhoea 219.53 13.95 2195 298666 878294 78565233
Oedema peripheral 217.98 13.95 386 300475 251902 79191625
Urinary tract infection 210.32 13.95 451 300410 274061 79169466
Epistaxis 208.12 13.95 80 300781 111435 79332092
Hallucination 206.41 13.95 37 300824 85708 79357819
Hyperhidrosis 203.08 13.95 164 300697 151328 79292199
Type 2 diabetes mellitus 203.05 13.95 573 300288 56549 79386978
Vision blurred 202.62 13.95 73 300788 105825 79337702
Renal failure 198.67 13.95 281 300580 200687 79242840
Mental status changes 198.22 13.95 14 300847 66945 79376582
Cognitive disorder 197.59 13.95 18 300843 69908 79373619
Dizziness 195.46 13.95 1175 299686 525266 78918261
Balance disorder 189.39 13.95 68 300793 98789 79344738
Sinusitis 188.74 13.95 1324 299537 194177 79249350
Therapeutic response decreased 187.38 13.95 617 300244 66236 79377291
Hyperglycaemia 186.21 13.95 23 300838 70312 79373215
Dysphagia 184.99 13.95 116 300745 122020 79321507
Pancytopenia 183.21 13.95 213 300648 165532 79277995
Unresponsive to stimuli 183.20 13.95 6 300855 55782 79387745
Neutrophil count decreased 181.08 13.95 64 300797 93895 79349632
Impaired work ability 178.07 13.95 289 300572 19392 79424135
White blood cell count decreased 177.58 13.95 272 300589 188016 79255511
Respiratory distress 176.22 13.95 11 300850 58328 79385199
Sciatica 175.88 13.95 388 300473 32834 79410693
Skin necrosis 175.20 13.95 274 300587 17813 79425714
Disorientation 175.14 13.95 17 300844 62759 79380768
Apparent death 174.88 13.95 118 300743 2747 79440780
Encephalopathy 173.72 13.95 24 300837 67373 79376154
Pneumonia 173.09 13.95 1625 299236 658621 78784906
Transplant dysfunction 172.22 13.95 172 300689 7049 79436478
Chest discomfort 172.20 13.95 160 300701 137884 79305643
Adverse drug reaction 170.45 13.95 595 300266 65797 79377730
Respiratory arrest 167.59 13.95 13 300848 57537 79385990
Sedation 165.53 13.95 7 300854 51888 79391639
Vomiting 164.72 13.95 1662 299199 664166 78779361
Intentional product misuse 162.09 13.95 78 300783 95087 79348440
Dysarthria 160.99 13.95 30 300831 67592 79375935
Pneumonia aspiration 160.96 13.95 29 300832 66938 79376589
Ulcer 158.62 13.95 350 300511 29622 79413905
Neoplasm progression 158.36 13.95 9 300852 51673 79391854
Liver injury 157.31 13.95 521 300340 56093 79387434
Multiple sclerosis relapse 156.48 13.95 4 300857 46529 79396998
Musculoskeletal disorder 154.81 13.95 285 300576 21163 79422364
Psoriasis 152.99 13.95 707 300154 88880 79354647
Liver function test increased 152.28 13.95 410 300451 39363 79404164
Abdominal pain 152.20 13.95 855 300006 388714 79054813
Joint effusion 150.21 13.95 255 300606 17759 79425768
Blood bilirubin increased 150.15 13.95 33 300828 66199 79377328
Ascites 149.89 13.95 49 300812 75513 79368014
Seronegative arthritis 148.92 13.95 131 300730 4561 79438966
Haemorrhage 148.72 13.95 79 300782 91039 79352488
Blood glucose increased 148.49 13.95 129 300732 114846 79328681
Pulmonary oedema 147.78 13.95 74 300787 88180 79355347
Contusion 147.32 13.95 1014 299847 147762 79295765
Orthostatic hypotension 147.14 13.95 19 300842 56145 79387382
Wrong technique in product usage process 144.62 13.95 49 300812 73826 79369701
Dyspnoea exertional 144.32 13.95 74 300787 86999 79356528
Serotonin syndrome 143.86 13.95 6 300855 45021 79398506
Hypervolaemia 142.32 13.95 4 300857 42686 79400841
Myalgia 141.27 13.95 306 300555 185335 79258192
Cerebral haemorrhage 140.74 13.95 24 300837 57649 79385878
Chest pain 139.14 13.95 570 300291 281734 79161793
Ovarian cyst 138.59 13.95 203 300658 12452 79431075
Dislocation of vertebra 137.36 13.95 159 300702 7721 79435806
Breast cancer stage III 136.81 13.95 177 300684 9649 79433878
Blood creatine phosphokinase increased 136.22 13.95 40 300821 66050 79377477
Red blood cell sedimentation rate 135.39 13.95 134 300727 5431 79438096
Musculoskeletal deformity 134.85 13.95 80 300781 1476 79442051
Exostosis 134.48 13.95 234 300627 16624 79426903
Acute respiratory failure 134.30 13.95 30 300831 59511 79384016
Haematuria 134.16 13.95 46 300815 68790 79374737
Blood pressure decreased 134.12 13.95 107 300754 99359 79344168
Aggression 134.07 13.95 17 300844 50941 79392586
Blood creatinine increased 134.06 13.95 237 300624 154820 79288707
Nodule 133.73 13.95 279 300582 22715 79420812
Human antichimeric antibody positive 133.48 13.95 81 300780 1560 79441967
Pain in extremity 132.90 13.95 2021 298840 362517 79081010
Melaena 132.76 13.95 33 300828 60857 79382670
Plasma cell myeloma 132.56 13.95 21 300840 53238 79390289
Finger deformity 132.29 13.95 152 300709 7322 79436205
Hepatic failure 131.87 13.95 34 300827 61178 79382349
Acute myocardial infarction 128.38 13.95 65 300796 76971 79366556
Alanine aminotransferase abnormal 127.03 13.95 162 300699 8705 79434822
Blood urea increased 126.63 13.95 17 300844 48773 79394754
Restlessness 126.06 13.95 14 300847 46478 79397049
Pulmonary embolism 124.84 13.95 290 300571 171364 79272163
Disturbance in attention 124.28 13.95 21 300840 50780 79392747
COVID-19 124.06 13.95 255 300606 157419 79286108
Body height below normal 123.99 13.95 84 300777 1969 79441558
Transient ischaemic attack 122.02 13.95 25 300836 52670 79390857
Abnormal behaviour 119.29 13.95 4 300857 36417 79407110
Sleep disorder 119.21 13.95 638 300223 85039 79358488
Renal impairment 117.63 13.95 263 300598 157520 79286007
Pulmonary hypertension 117.34 13.95 20 300841 48060 79395467
Aphasia 117.28 13.95 18 300843 46714 79396813
Loss of consciousness 117.16 13.95 290 300571 167653 79275874
Fluid retention 114.69 13.95 60 300801 69749 79373778
Haemoglobin decreased 114.16 13.95 441 300420 221678 79221849
Chills 113.89 13.95 274 300587 159960 79283567
Decreased appetite 113.76 13.95 790 300071 341628 79101899
Cough 113.30 13.95 864 299997 365925 79077602
Cardiogenic shock 112.69 13.95 13 300848 41901 79401626
Hypophagia 112.66 13.95 18 300843 45349 79398178
Abdominal distension 112.62 13.95 173 300688 119477 79324050
Neuropathy peripheral 112.46 13.95 227 300634 141078 79302449
Urinary retention 111.83 13.95 37 300824 56593 79386934
Chronic obstructive pulmonary disease 111.31 13.95 95 300766 85324 79358203
Generalised tonic-clonic seizure 110.00 13.95 17 300844 43893 79399634
Skin ulcer 109.75 13.95 450 300411 53700 79389827
Pleural effusion 109.21 13.95 241 300620 145021 79298506
Hypomagnesaemia 109.16 13.95 22 300839 46889 79396638
Lethargy 108.91 13.95 88 300773 81204 79362323
Diverticulitis 108.79 13.95 401 300460 45535 79397992
Anti-cyclic citrullinated peptide antibody 108.64 13.95 122 300739 5730 79437797
Neurotoxicity 108.58 13.95 3 300858 32515 79411012
Dactylitis 108.19 13.95 87 300774 2670 79440857
Pulmonary fibrosis 107.78 13.95 389 300472 43723 79399804
Altered state of consciousness 107.45 13.95 18 300843 43804 79399723
Tenderness 106.33 13.95 259 300602 23383 79420144
Myocardial infarction 104.26 13.95 351 300510 183778 79259749
Bursitis 104.19 13.95 335 300526 35509 79408018
Haematoma 103.25 13.95 34 300827 52161 79391366
Basal cell carcinoma 102.97 13.95 343 300518 37032 79406495
Physical disability 102.52 13.95 91 300770 3207 79440320
Drug level increased 102.46 13.95 14 300847 39637 79403890
Drug eruption 101.93 13.95 381 300480 43554 79399973
Chronic kidney disease 101.30 13.95 62 300799 66092 79377435
Dysuria 101.12 13.95 33 300828 50918 79392609
Psychotic disorder 99.34 13.95 18 300843 41384 79402143
Osteonecrosis of jaw 99.07 13.95 21 300840 43205 79400322
Ventricular tachycardia 98.98 13.95 19 300842 41916 79401611
Lower limb fracture 98.79 13.95 249 300612 22966 79420561
Tongue disorder 98.73 13.95 184 300677 13791 79429736
Neoplasm malignant 98.62 13.95 304 300557 31506 79412021
Onychomycosis 98.51 13.95 138 300723 8123 79435404
Blood potassium decreased 97.98 13.95 27 300834 46485 79397042
Paraesthesia 97.88 13.95 339 300522 175984 79267543
Dyskinesia 96.19 13.95 25 300836 44748 79398779
Coronary artery disease 95.30 13.95 65 300796 65409 79378118
Deep vein thrombosis postoperative 94.71 13.95 156 300705 10596 79432931
Pyrexia 94.71 13.95 1899 298962 676810 78766717
Haemoptysis 93.68 13.95 47 300814 55952 79387575
Haematemesis 93.41 13.95 40 300821 52224 79391303
Drug withdrawal syndrome 92.76 13.95 11 300850 34707 79408820
Clostridium difficile colitis 92.04 13.95 8 300853 32275 79411252
Pallor 91.60 13.95 37 300824 50025 79393502
Cholestasis 91.37 13.95 41 300820 52068 79391459
Nail disorder 91.28 13.95 162 300699 11690 79431837
Ventricular fibrillation 90.78 13.95 8 300853 31918 79411609
Myoclonus 90.73 13.95 3 300858 27657 79415870
Facet joint syndrome 90.30 13.95 157 300704 11145 79432382
Pancreatitis acute 90.21 13.95 37 300824 49567 79393960
Bone marrow failure 89.94 13.95 40 300821 51067 79392460
Tendonitis 89.56 13.95 244 300617 23586 79419941
Urinary incontinence 89.51 13.95 22 300839 40887 79402640
Upper gastrointestinal haemorrhage 89.10 13.95 23 300838 41357 79402170
Arrhythmia 88.95 13.95 61 300800 61211 79382316
Retinitis 88.68 13.95 108 300753 5535 79437992
Shock 88.57 13.95 27 300834 43521 79400006
Adjustment disorder with depressed mood 88.49 13.95 138 300723 8948 79434579
Wrist deformity 87.78 13.95 69 300792 2048 79441479
Therapy non-responder 87.15 13.95 622 300239 91683 79351844
Prescribed overdose 86.62 13.95 327 300534 37556 79405971
Sinus tachycardia 86.52 13.95 17 300844 36891 79406636
Irritability 86.45 13.95 24 300837 41120 79402407
Terminal state 85.81 13.95 99 300762 4790 79438737
Intestinal sepsis 85.25 13.95 49 300812 850 79442677
Hepatic enzyme abnormal 85.12 13.95 125 300736 7685 79435842
Septic shock 84.89 13.95 213 300648 122588 79320939
Bone swelling 84.62 13.95 62 300799 1652 79441875
Lupus-like syndrome 83.95 13.95 171 300690 13686 79429841
Fatigue 83.86 13.95 4297 296564 925430 78518097
Osteoporosis 82.92 13.95 414 300447 53698 79389829
Flushing 82.70 13.95 128 300733 88140 79355387
Haemorrhage intracranial 82.01 13.95 4 300857 26189 79417338
Subdural haematoma 81.46 13.95 11 300850 31423 79412104
Labelled drug-drug interaction medication error 81.20 13.95 6 300855 27644 79415883
Pulmonary arterial hypertension 80.95 13.95 7 300854 28359 79415168
Lymphocyte count decreased 80.14 13.95 39 300822 47250 79396277
Presbyacusis 79.92 13.95 72 300789 2588 79440939
Electrolyte imbalance 79.57 13.95 11 300850 30870 79412657
Angioedema 79.45 13.95 102 300759 75933 79367594
Presyncope 79.02 13.95 28 300833 41026 79402501
Cytomegalovirus infection 78.87 13.95 31 300830 42613 79400914
Wheelchair user 78.49 13.95 106 300755 6026 79437501
Thyroid neoplasm 78.48 13.95 77 300784 3087 79440440
Withdrawal syndrome 78.37 13.95 6 300855 26848 79416679
Gait inability 78.08 13.95 433 300428 58484 79385043
Cerebral infarction 76.91 13.95 38 300823 45638 79397889
Hallucination, visual 76.88 13.95 15 300846 32714 79410813
Ejection fraction decreased 76.82 13.95 18 300843 34559 79408968
Tachypnoea 76.80 13.95 14 300847 32049 79411478
X-ray abnormal 76.72 13.95 102 300759 5711 79437816
Blood sodium decreased 76.53 13.95 16 300845 33239 79410288
Jaundice 76.27 13.95 54 300807 53295 79390232
Acne 76.21 13.95 251 300610 26939 79416588
Hyperbilirubinaemia 75.95 13.95 4 300857 24514 79419013
Fine motor skill dysfunction 75.36 13.95 97 300764 5260 79438267
Diplopia 75.19 13.95 17 300844 33449 79410078
Therapy cessation 75.12 13.95 24 300837 37538 79405989
Liver disorder 74.87 13.95 499 300362 71918 79371609
Status epilepticus 74.79 13.95 5 300856 25036 79418491
Obesity 74.44 13.95 296 300565 34829 79408698
Hepatic function abnormal 74.41 13.95 100 300761 73007 79370520
Muscle spasms 73.94 13.95 373 300488 174357 79269170
Onychomadesis 73.88 13.95 95 300766 5147 79438380
Tumour lysis syndrome 73.86 13.95 4 300857 23935 79419592
Joint injury 73.74 13.95 273 300588 31062 79412465
Posterior reversible encephalopathy syndrome 73.61 13.95 7 300854 26274 79417253
Blood iron abnormal 73.32 13.95 52 300809 1315 79442212
Bloody discharge 73.20 13.95 60 300801 1893 79441634
Obstructive airways disorder 72.68 13.95 15 300846 31444 79412083
Lip dry 72.66 13.95 172 300689 15246 79428281
Gastric disorder 72.65 13.95 307 300554 37126 79406401
Hemiparesis 72.15 13.95 19 300842 33714 79409813
Infusion site reaction 72.11 13.95 77 300784 3416 79440111
Fear of injection 72.07 13.95 113 300748 7361 79436166
Coagulopathy 72.02 13.95 23 300838 35983 79407544
Circulatory collapse 71.98 13.95 26 300835 37642 79405885
Product administration error 71.91 13.95 16 300845 31830 79411697
Diabetic ketoacidosis 71.52 13.95 20 300841 34102 79409425
Accidental overdose 71.21 13.95 30 300831 39551 79403976
International normalised ratio fluctuation 71.06 13.95 76 300785 3378 79440149
Respiratory depression 70.82 13.95 10 300851 27620 79415907
Cellulitis 70.19 13.95 196 300665 108864 79334663
Hepatocellular injury 69.59 13.95 47 300814 47546 79395981
Bone density abnormal 69.52 13.95 71 300790 2989 79440538
Extrapyramidal disorder 69.32 13.95 4 300857 22675 79420852
Dysgeusia 69.25 13.95 68 300793 57109 79386418
Full blood count abnormal 69.17 13.95 33 300828 40441 79403086
Adverse reaction 68.78 13.95 125 300736 9189 79434338
Full blood count decreased 68.05 13.95 10 300851 26809 79416718
Immobile 68.04 13.95 106 300755 6867 79436660
Bone cyst 67.93 13.95 74 300787 3359 79440168
Cardiac disorder 67.89 13.95 89 300772 65668 79377859
Dystonia 67.87 13.95 3 300858 21396 79422131
Hospitalisation 67.05 13.95 161 300700 94075 79349452
Angina pectoris 66.83 13.95 58 300803 51674 79391853
Acute myeloid leukaemia 66.82 13.95 17 300844 30868 79412659
Depressed mood 66.80 13.95 51 300810 48429 79395098
Ischaemic stroke 66.56 13.95 21 300840 33110 79410417
Maternal exposure timing unspecified 66.47 13.95 95 300766 5697 79437830
Dry skin 66.22 13.95 96 300765 67899 79375628
Wound infection 65.93 13.95 220 300641 23771 79419756
Product prescribing error 65.87 13.95 44 300817 44769 79398758
Pleural thickening 65.59 13.95 68 300793 2914 79440613
Tenosynovitis stenosans 65.58 13.95 69 300792 3009 79440518
Poisoning 65.12 13.95 9 300852 25263 79418264
Myelodysplastic syndrome 64.94 13.95 17 300844 30284 79413243
Emotional distress 64.70 13.95 35 300826 39934 79403593
Gastrooesophageal reflux disease 64.41 13.95 191 300670 104055 79339472
Joint dislocation 64.21 13.95 174 300687 16765 79426762
Coeliac disease 63.99 13.95 136 300725 11215 79432312
Toxic epidermal necrolysis 63.89 13.95 45 300816 44536 79398991
Right ventricular failure 63.89 13.95 7 300854 23490 79420037
Hypothermia 63.86 13.95 6 300855 22740 79420787
Antibody test positive 63.83 13.95 65 300796 2727 79440800
Acute respiratory distress syndrome 63.79 13.95 44 300817 44023 79399504
Colitis 63.37 13.95 112 300749 73195 79370332
Suicidal ideation 63.00 13.95 120 300741 76220 79367307
Blood alkaline phosphatase increased 62.87 13.95 89 300772 63575 79379952
Dermatitis allergic 62.58 13.95 180 300681 17950 79425577
Autoimmune disorder 62.33 13.95 170 300691 16442 79427085
Drug tolerance 62.26 13.95 115 300746 8560 79434967
Ataxia 62.02 13.95 10 300851 25029 79418498
Hyperthyroidism 61.98 13.95 6 300855 22203 79421324
Neck deformity 61.75 13.95 53 300808 1784 79441743
Blood glucose decreased 61.67 13.95 12 300849 26222 79417305
Drug specific antibody 61.57 13.95 62 300799 2566 79440961
Hyperlipidaemia 61.20 13.95 12 300849 26081 79417446
Muscle twitching 61.10 13.95 10 300851 24754 79418773
Pleural fibrosis 61.06 13.95 77 300784 4090 79439437
Device dislocation 60.79 13.95 12 300849 25958 79417569
Bacteraemia 60.47 13.95 24 300837 32800 79410727
Device issue 60.45 13.95 14 300847 27094 79416433
Pulmonary congestion 60.42 13.95 14 300847 27086 79416441
Subarachnoid haemorrhage 60.09 13.95 10 300851 24455 79419072
Speech disorder 60.09 13.95 70 300791 54375 79389152
Shock haemorrhagic 59.93 13.95 4 300857 20056 79423471
Synovial cyst 59.55 13.95 123 300738 9942 79433585
Pericardial effusion 59.53 13.95 52 300809 46185 79397342
Rheumatoid factor negative 59.20 13.95 43 300818 1130 79442397
C-reactive protein 59.11 13.95 83 300778 4896 79438631
Live birth 58.91 13.95 180 300681 18564 79424963
Arthrodesis 58.63 13.95 58 300803 2349 79441178
Skin exfoliation 58.52 13.95 73 300788 55027 79388500
Eosinophilia 58.38 13.95 51 300810 45294 79398233
Peripheral venous disease 57.90 13.95 161 300700 15748 79427779
Therapy interrupted 57.60 13.95 23 300838 31318 79412209
Left ventricular dysfunction 57.43 13.95 4 300857 19357 79424170
Atrial flutter 57.41 13.95 7 300854 21618 79421909
Injection site pain 57.33 13.95 273 300588 129565 79313962
Torsade de pointes 57.26 13.95 4 300857 19308 79424219
Device related infection 57.03 13.95 29 300832 34265 79409262
Hypercalcaemia 56.75 13.95 291 300570 38139 79405388
Ovarian neoplasm 56.63 13.95 33 300828 588 79442939
Hypophosphataemia 56.59 13.95 5 300856 19908 79423619
Drug ineffective for unapproved indication 56.41 13.95 66 300795 51172 79392355
Transfusion 56.39 13.95 7 300854 21323 79422204
Epilepsy 56.28 13.95 43 300818 40817 79402710
Cyanosis 56.16 13.95 13 300848 25169 79418358
Bone pain 55.97 13.95 77 300784 55665 79387862
Sudden death 55.74 13.95 9 300852 22502 79421025
Muscular weakness 55.70 13.95 366 300495 160363 79283164
Ileus 55.61 13.95 15 300846 26196 79417331
Bone density decreased 55.58 13.95 142 300719 13205 79430322
Acute hepatic failure 55.51 13.95 22 300839 30091 79413436
Red cell distribution width decreased 55.09 13.95 52 300809 1986 79441541
Thrombotic microangiopathy 54.86 13.95 6 300855 20163 79423364
Tuberculin test positive 54.82 13.95 66 300795 3342 79440185
Head injury 54.51 13.95 37 300824 37332 79406195
Mitral valve incompetence 54.10 13.95 20 300841 28545 79414982
Synovial fluid analysis 54.07 13.95 55 300806 2304 79441223
Vascular access complication 53.93 13.95 53 300808 2129 79441398
Spinal stenosis 53.76 13.95 156 300705 15635 79427892
Metastases to bone 53.71 13.95 13 300848 24414 79419113
Hepatitis 53.45 13.95 377 300484 55350 79388177
General physical health deterioration 53.37 13.95 1388 299473 273850 79169677
Pulmonary thrombosis 53.31 13.95 132 300729 12039 79431488
Haemodialysis 53.19 13.95 4 300857 18164 79425363
Osteopenia 52.79 13.95 171 300690 18193 79425334
Hip fracture 52.69 13.95 25 300836 30736 79412791
Brain oedema 52.59 13.95 15 300846 25248 79418279
Aspiration 52.36 13.95 7 300854 20151 79423376
Weight increased 51.81 13.95 1392 299469 275994 79167533
Hypovolaemia 51.49 13.95 4 300857 17687 79425840
Mycotic allergy 51.42 13.95 44 300817 1475 79442052
Mental disorder 51.27 13.95 27 300834 31275 79412252
Weight decreased 51.15 13.95 988 299873 354210 79089317
Leukocytosis 51.12 13.95 53 300808 43402 79400125
Delusion 50.94 13.95 8 300853 20415 79423112
Nephropathy toxic 50.93 13.95 8 300853 20411 79423116
Peritonitis 50.83 13.95 21 300840 28015 79415512
Rheumatoid lung 50.75 13.95 71 300790 4174 79439353
Hepatic cirrhosis 50.63 13.95 263 300598 34643 79408884
Inappropriate antidiuretic hormone secretion 50.55 13.95 18 300843 26295 79417232
Axial spondyloarthritis 50.45 13.95 30 300831 556 79442971
Visual acuity reduced 50.40 13.95 24 300837 29445 79414082
Pregnancy 50.40 13.95 218 300643 26633 79416894
Nervousness 50.21 13.95 32 300829 33383 79410144
Neutrophil count increased 50.18 13.95 24 300837 29372 79414155
Small intestinal obstruction 50.15 13.95 20 300841 27252 79416275
Mucosal inflammation 49.99 13.95 134 300727 75446 79368081
Myocardial ischaemia 49.81 13.95 17 300844 25502 79418025
Uveitis 49.55 13.95 158 300703 16672 79426855
Oliguria 49.47 13.95 3 300858 16306 79427221
Diabetes mellitus inadequate control 49.42 13.95 15 300846 24249 79419278
Injury 49.40 13.95 478 300383 77018 79366509
Lacrimation increased 49.35 13.95 12 300849 22465 79421062
Lyme disease 49.25 13.95 62 300799 3288 79440239
Hepatic encephalopathy 49.11 13.95 15 300846 24151 79419376
Myelosuppression 48.71 13.95 48 300813 40248 79403279
Staphylococcal infection 48.66 13.95 91 300770 58204 79385323
Mydriasis 48.63 13.95 5 300856 17638 79425889
Tricuspid valve incompetence 48.54 13.95 8 300853 19704 79423823
Palpitations 48.18 13.95 280 300581 126330 79317197
Cardiac failure acute 48.16 13.95 7 300854 18922 79424605
Arteriosclerosis 48.14 13.95 6 300855 18221 79425306
Mean platelet volume decreased 48.13 13.95 56 300805 2734 79440793
Transplant rejection 47.98 13.95 172 300689 19265 79424262
Scleritis 47.88 13.95 70 300791 4286 79439241
Coordination abnormal 47.47 13.95 5 300856 17307 79426220
Joint arthroplasty 47.28 13.95 55 300806 2685 79440842
Cholelithiasis 46.85 13.95 79 300782 52585 79390942
Gamma-glutamyltransferase increased 46.85 13.95 84 300777 54596 79388931
Pollakiuria 46.81 13.95 43 300818 37274 79406253
Extremity contracture 46.45 13.95 44 300817 1688 79441839
Lymphopenia 46.28 13.95 29 300832 30528 79412999
Oxygen saturation decreased 46.16 13.95 291 300570 128756 79314771
Pancreatitis 45.80 13.95 121 300740 68454 79375073
Lip swelling 45.79 13.95 52 300809 40859 79402668
Malnutrition 45.67 13.95 14 300847 22488 79421039
Blood magnesium increased 45.47 13.95 61 300800 3445 79440082
Ankle arthroplasty 45.27 13.95 41 300820 1484 79442043
Sleep apnoea syndrome 44.62 13.95 43 300818 36435 79407092
Klebsiella infection 44.53 13.95 4 300857 15716 79427811
Hypercholesterolaemia 44.50 13.95 189 300672 22906 79420621
Acidosis 44.48 13.95 10 300851 19752 79423775
Arteriosclerosis coronary artery 44.39 13.95 7 300854 17809 79425718
Accidental exposure to product 44.38 13.95 32 300829 31290 79412237
Drug reaction with eosinophilia and systemic symptoms 44.32 13.95 403 300458 63841 79379686
Enterococcal infection 44.32 13.95 4 300857 15656 79427871
Ventricular extrasystoles 44.29 13.95 10 300851 19694 79423833
Mental impairment 44.13 13.95 9 300852 19027 79424500
Steroid dependence 44.06 13.95 52 300809 2578 79440949
Product quality issue 43.90 13.95 38 300823 33902 79409625
Pulmonary haemorrhage 43.77 13.95 3 300858 14714 79428813
Schizophrenia 43.54 13.95 4 300857 15436 79428091
Paranoia 43.40 13.95 10 300851 19422 79424105
Lower gastrointestinal haemorrhage 43.35 13.95 5 300856 16120 79427407
Complication associated with device 43.31 13.95 7 300854 17489 79426038
Hypernatraemia 42.83 13.95 3 300858 14448 79429079
Throat irritation 42.70 13.95 55 300806 40891 79402636
Aplastic anaemia 42.49 13.95 8 300853 17897 79425630
Hypersomnia 42.33 13.95 17 300844 23069 79420458
Dementia 42.30 13.95 20 300841 24639 79418888
Dialysis 42.24 13.95 9 300852 18453 79425074
Activated partial thromboplastin time prolonged 42.03 13.95 3 300858 14225 79429302
Supraventricular tachycardia 41.81 13.95 14 300847 21256 79422271
Throat tightness 41.56 13.95 27 300834 27880 79415647
Pulmonary toxicity 41.50 13.95 125 300736 12789 79430738
Prothrombin time prolonged 41.30 13.95 7 300854 16892 79426635
Anal incontinence 41.28 13.95 9 300852 18159 79425368
Walking aid user 41.26 13.95 107 300754 10041 79433486
Blood loss anaemia 41.18 13.95 5 300856 15493 79428034
Blood triglycerides increased 41.10 13.95 14 300847 21026 79422501
Retching 41.04 13.95 8 300853 17459 79426068
Injection site erythema 40.94 13.95 154 300707 78043 79365484
Troponin increased 40.89 13.95 11 300850 19244 79424283
Haemodynamic instability 40.75 13.95 8 300853 17374 79426153
Myositis 40.61 13.95 11 300850 19157 79424370
Tuberculosis 40.55 13.95 138 300723 15060 79428467
Multiple fractures 40.53 13.95 92 300769 7934 79435593
Hot flush 40.44 13.95 92 300769 54785 79388742
Rectal haemorrhage 40.12 13.95 150 300711 76150 79367377
Vaginal haemorrhage 40.11 13.95 16 300845 21801 79421726
Nocturia 40.08 13.95 3 300858 13678 79429849
Hallucination, auditory 40.02 13.95 14 300847 20679 79422848
Second primary malignancy 39.72 13.95 4 300857 14346 79429181
Panic attack 39.49 13.95 21 300840 24195 79419332
Foot fracture 39.38 13.95 176 300685 21805 79421722
Flatulence 39.02 13.95 63 300798 42661 79400866
Cardiomyopathy 38.72 13.95 31 300830 28743 79414784
Bronchospasm 38.47 13.95 23 300838 24836 79418691
Drug dependence 38.30 13.95 59 300802 40710 79402817
Blood pressure increased 38.18 13.95 564 300297 210796 79232731
Hepatitis cholestatic 37.99 13.95 4 300857 13848 79429679
Bedridden 37.96 13.95 116 300745 11963 79431564
Blood magnesium decreased 37.88 13.95 8 300853 16504 79427023
Prescribed underdose 37.83 13.95 215 300646 29299 79414228
Osteonecrosis 37.63 13.95 37 300824 31058 79412469
Neck mass 37.59 13.95 63 300798 4341 79439186
Disseminated intravascular coagulation 37.52 13.95 48 300813 35794 79407733
Vertigo 37.51 13.95 134 300727 68948 79374579
Pustular psoriasis 37.41 13.95 66 300795 4740 79438787
Interstitial lung disease 37.40 13.95 615 300246 111985 79331542
Gastritis 37.40 13.95 78 300783 47915 79395612
Hypotonia 37.21 13.95 3 300858 12867 79430660
Polyuria 37.18 13.95 6 300855 15008 79428519
Hyperthermia 37.01 13.95 11 300850 18026 79425501
Chromaturia 36.88 13.95 26 300835 25720 79417807
Oesophagitis 36.85 13.95 23 300838 24266 79419261
Hepatic cytolysis 36.85 13.95 29 300832 27122 79416405
Acute coronary syndrome 36.47 13.95 17 300844 21116 79422411
Progressive multifocal leukoencephalopathy 36.44 13.95 16 300845 20584 79422943
Bladder cancer 36.43 13.95 14 300847 19512 79424015
Acute generalised exanthematous pustulosis 36.37 13.95 10 300851 17244 79426283
Joint ankylosis 36.35 13.95 43 300818 2137 79441390
Angina unstable 35.94 13.95 9 300852 16518 79427009
Cytology abnormal 35.89 13.95 20 300841 326 79443201
Incorrect dose administered 35.67 13.95 158 300703 76472 79367055
Bronchopulmonary aspergillosis 35.39 13.95 20 300841 22274 79421253
Aspergillus infection 35.31 13.95 14 300847 19147 79424380
Clostridium difficile infection 35.30 13.95 67 300794 42618 79400909
Mass excision 34.89 13.95 20 300841 345 79443182
Hemiplegia 34.77 13.95 7 300854 14932 79428595
Premature delivery 34.54 13.95 23 300838 23444 79420083
Incontinence 34.32 13.95 6 300855 14158 79429369
Neck pain 34.23 13.95 435 300426 74982 79368545
Joint space narrowing 34.22 13.95 25 300836 663 79442864
Device difficult to use 33.94 13.95 5 300856 13380 79430147
Atrioventricular block 33.91 13.95 6 300855 14035 79429492
Erectile dysfunction 33.86 13.95 7 300854 14657 79428870
Metastases to central nervous system 33.57 13.95 10 300851 16365 79427162
Immune reconstitution inflammatory syndrome 33.24 13.95 6 300855 13835 79429692
Decubitus ulcer 33.24 13.95 9 300852 15678 79427849
Anaphylactic shock 32.95 13.95 53 300808 35943 79407584
Gout 32.88 13.95 27 300834 24722 79418805
Pseudomonas infection 32.83 13.95 19 300842 20884 79422643
Mania 32.59 13.95 14 300847 18246 79425281
Appendicitis 32.52 13.95 19 300842 20775 79422752
Swollen tongue 32.49 13.95 70 300791 42500 79401027
Multiple allergies 32.45 13.95 100 300761 10360 79433167
Renal tubular necrosis 32.43 13.95 28 300833 25011 79418516
Rash maculo-papular 32.33 13.95 106 300755 55972 79387555
Restless legs syndrome 31.93 13.95 18 300843 20074 79423453
Escherichia infection 31.86 13.95 14 300847 18003 79425524
Blindness 31.85 13.95 36 300825 28347 79415180
Renal injury 31.81 13.95 12 300849 16915 79426612
Iron deficiency anaemia 31.70 13.95 30 300831 25642 79417885
Central nervous system lesion 31.67 13.95 6 300855 13362 79430165
Neuralgia 31.66 13.95 48 300813 33336 79410191
Faeces discoloured 31.55 13.95 38 300823 29089 79414438
Pneumonia fungal 31.36 13.95 3 300858 11207 79432320
Limb discomfort 31.36 13.95 222 300639 32628 79410899
Lymphoproliferative disorder 31.33 13.95 67 300794 5548 79437979
Nausea 31.30 13.95 3149 297712 954047 78489480
Sensory disturbance 31.29 13.95 9 300852 15068 79428459
Electrocardiogram abnormal 31.22 13.95 12 300849 16725 79426802
No adverse event 31.09 13.95 58 300803 37134 79406393
Blood lactate dehydrogenase increased 31.08 13.95 63 300798 39107 79404420
Product substitution issue 30.98 13.95 19 300842 20237 79423290
Atrioventricular block first degree 30.91 13.95 5 300856 12486 79431041
Anger 30.88 13.95 13 300848 17149 79426378
COVID-19 pneumonia 30.86 13.95 38 300823 28811 79414716
Rheumatic disorder 30.80 13.95 48 300813 3110 79440417
Apnoea 30.55 13.95 4 300857 11700 79431827
Myopathy 30.47 13.95 20 300841 20543 79422984
Lung infiltration 30.43 13.95 25 300836 22887 79420640
Deafness neurosensory 30.41 13.95 75 300786 6823 79436704
Lipase increased 30.40 13.95 12 300849 16454 79427073
Paraesthesia oral 30.22 13.95 20 300841 20451 79423076
Intestinal obstruction 30.20 13.95 74 300787 42946 79400581
Food intolerance 30.15 13.95 53 300808 3795 79439732
Feeling abnormal 30.08 13.95 421 300440 158778 79284749
Faecaloma 30.07 13.95 4 300857 11560 79431967
Lymphoma 29.94 13.95 138 300723 17322 79426205
Hypoalbuminaemia 29.86 13.95 22 300839 21275 79422252
Abdominal pain lower 29.85 13.95 46 300815 31736 79411791
Hypertensive crisis 29.71 13.95 21 300840 20749 79422778
Immune thrombocytopenia 29.69 13.95 15 300846 17790 79425737
Depression 29.66 13.95 608 300253 216182 79227345
Bacterial infection 29.64 13.95 45 300816 31235 79412292
Hypertriglyceridaemia 29.58 13.95 6 300855 12734 79430793
Hypothyroidism 29.54 13.95 100 300761 52292 79391235
Anovulatory cycle 29.53 13.95 13 300848 123 79443404
Cartilage atrophy 29.50 13.95 14 300847 160 79443367
Intestinal ischaemia 29.30 13.95 7 300854 13263 79430264
Metastases to lung 29.26 13.95 16 300845 18147 79425380
Jaundice cholestatic 29.12 13.95 4 300857 11280 79432247
Hepatotoxicity 29.01 13.95 309 300552 51043 79392484
Bundle branch block right 29.00 13.95 4 300857 11247 79432280
Paralysis 29.00 13.95 7 300854 13170 79430357
Cardiomegaly 28.95 13.95 34 300827 26318 79417209
Device occlusion 28.81 13.95 5 300856 11861 79431666
Lupus vulgaris 28.74 13.95 48 300813 3298 79440229
Mean cell volume decreased 28.73 13.95 60 300801 4887 79438640
Colitis ischaemic 28.67 13.95 11 300850 15348 79428179
Pneumonitis 28.62 13.95 125 300736 60735 79382792
Hyperuricaemia 28.59 13.95 5 300856 11794 79431733
Leukopenia 28.58 13.95 291 300570 116222 79327305
Asthma 28.56 13.95 349 300512 134746 79308781
Investigation abnormal 28.42 13.95 37 300824 2029 79441498
Elbow deformity 28.29 13.95 32 300829 1515 79442012
Tinnitus 28.27 13.95 80 300781 44253 79399274
Spondylitis 28.20 13.95 58 300803 4673 79438854
Respiratory tract infection 28.09 13.95 92 300769 48597 79394930
Shoulder arthroplasty 28.08 13.95 47 300814 3235 79440292
Hypovolaemic shock 28.06 13.95 6 300855 12270 79431257
Synovial disorder 28.04 13.95 36 300825 1947 79441580
Polyneuropathy 27.80 13.95 30 300831 24121 79419406
Personality change 27.73 13.95 3 300858 10167 79433360
Device leakage 27.66 13.95 4 300857 10852 79432675
Cushingoid 27.50 13.95 89 300772 9463 79434064
Urine output decreased 27.43 13.95 17 300844 18005 79425522
Precancerous cells present 27.41 13.95 28 300833 1179 79442348
Swelling face 27.34 13.95 157 300704 71055 79372472
Myocarditis 27.31 13.95 25 300836 21708 79421819
Granulomatous dermatitis 27.29 13.95 18 300843 403 79443124
Productive cough 27.24 13.95 208 300653 88123 79355404
Cyst 27.24 13.95 114 300747 13726 79429801
Lung disorder 27.12 13.95 441 300420 80116 79363411
Inflammatory pain 27.07 13.95 26 300835 1015 79442512
Antinuclear antibody positive 26.91 13.95 78 300783 7812 79435715
Glycosylated haemoglobin increased 26.87 13.95 20 300841 19240 79424287
Carpal tunnel syndrome 26.86 13.95 145 300716 19383 79424144
Crepitations 26.76 13.95 91 300770 9926 79433601
Infusion site pain 26.72 13.95 10 300851 14166 79429361
Cold sweat 26.63 13.95 19 300842 18680 79424847
Cerebral ischaemia 26.57 13.95 5 300856 11190 79432337
Rotator cuff repair 26.53 13.95 34 300827 1836 79441691
Gastric ulcer 26.50 13.95 55 300806 33850 79409677
Congestive cardiomyopathy 26.43 13.95 6 300855 11774 79431753
Spinal fusion surgery 26.40 13.95 60 300801 5178 79438349
Asphyxia 26.24 13.95 6 300855 11714 79431813
Blood urine present 26.17 13.95 25 300836 21272 79422255
Rhinitis allergic 26.07 13.95 7 300854 12262 79431265
Prostatic specific antigen increased 26.06 13.95 4 300857 10382 79433145
Heparin-induced thrombocytopenia 26.03 13.95 3 300858 9679 79433848
Benign prostatic hyperplasia 25.88 13.95 6 300855 11606 79431921
Spinal meningioma benign 25.86 13.95 11 300850 95 79443432
Feeling cold 25.64 13.95 43 300818 28686 79414841
Peritonitis bacterial 25.63 13.95 3 300858 9564 79433963
Skin burning sensation 25.63 13.95 9 300852 13263 79430264
Juvenile idiopathic arthritis 25.63 13.95 56 300805 4707 79438820
Metastases to liver 25.62 13.95 42 300819 28272 79415255
Pathogen resistance 25.59 13.95 11 300850 14331 79429196
Stevens-Johnson syndrome 25.48 13.95 70 300791 39096 79404431
Breast cancer 25.42 13.95 216 300645 33565 79409962
Device malfunction 25.41 13.95 26 300835 21422 79422105
Smear cervix abnormal 25.37 13.95 39 300822 2497 79441030
Product label confusion 25.36 13.95 31 300830 1595 79441932
Gingival bleeding 25.27 13.95 15 300846 16261 79427266
Rash erythematous 25.18 13.95 122 300739 57647 79385880
Eye swelling 25.15 13.95 38 300823 26430 79417097
Pulse absent 25.10 13.95 4 300857 10099 79433428
Erythema multiforme 25.05 13.95 18 300843 17633 79425894
Pulseless electrical activity 25.04 13.95 11 300850 14149 79429378
Foot operation 24.92 13.95 62 300799 5671 79437856
Rash pruritic 24.82 13.95 394 300467 71235 79372292
White blood cell count increased 24.82 13.95 172 300689 74461 79369066
Enteritis 24.75 13.95 12 300849 14571 79428956
Short stature 24.74 13.95 21 300840 696 79442831
Intervertebral disc annular tear 24.74 13.95 8 300853 28 79443499
Weber tuning fork test abnormal 24.64 13.95 11 300850 108 79443419
Hiatus hernia 24.63 13.95 31 300830 23281 79420246
Substance abuse 24.35 13.95 5 300856 10521 79433006
Cystitis haemorrhagic 24.27 13.95 3 300858 9169 79434358
Nervous system disorder 24.15 13.95 40 300821 26816 79416711
Oral lichen planus 24.11 13.95 22 300839 804 79442723
Exercise tolerance decreased 23.92 13.95 3 300858 9068 79434459
Mycobacterium tuberculosis complex test positive 23.91 13.95 40 300821 2752 79440775
Anticipatory anxiety 23.90 13.95 26 300835 1178 79442349
Blood pressure fluctuation 23.90 13.95 371 300490 66774 79376753
Nephropathy 23.87 13.95 4 300857 9734 79433793
Post procedural haemorrhage 23.80 13.95 11 300850 13733 79429794
Wrong product administered 23.72 13.95 3 300858 9009 79434518
Staphylococcal sepsis 23.68 13.95 13 300848 14713 79428814
Heart rate increased 23.61 13.95 317 300544 120407 79323120
Eructation 23.61 13.95 6 300855 10903 79432624
Ageusia 23.55 13.95 17 300844 16615 79426912
Vascular device infection 23.53 13.95 5 300856 10271 79433256
Systemic inflammatory response syndrome 23.51 13.95 7 300854 11458 79432069
Incorrect product administration duration 23.48 13.95 8 300853 12014 79431513
Night sweats 23.43 13.95 300 300561 51795 79391732
Toxic encephalopathy 23.43 13.95 7 300854 11433 79432094
Gastritis erosive 23.41 13.95 6 300855 10841 79432686
Pulmonary tuberculosis 23.30 13.95 74 300787 7791 79435736
Tender joint count increased 23.14 13.95 14 300847 268 79443259
Therapeutic product effect variable 23.13 13.95 33 300828 1976 79441551
Peripheral coldness 23.04 13.95 16 300845 15954 79427573
Colitis microscopic 23.02 13.95 91 300770 10677 79432850
Neurological symptom 22.93 13.95 3 300858 8780 79434747
Osteosclerosis 22.87 13.95 48 300813 3923 79439604
Psychomotor hyperactivity 22.86 13.95 18 300843 16831 79426696
Thirst 22.71 13.95 22 300839 18597 79424930
Cytomegalovirus infection reactivation 22.70 13.95 3 300858 8713 79434814
Amylase increased 22.70 13.95 7 300854 11202 79432325
Mean cell haemoglobin decreased 22.66 13.95 63 300798 6161 79437366
Left ventricular hypertrophy 22.65 13.95 7 300854 11184 79432343
Delirium 22.60 13.95 207 300654 84420 79359107
Hypocalcaemia 22.60 13.95 104 300757 49820 79393707
Generalised oedema 22.57 13.95 34 300827 23675 79419852
Colitis ulcerative 22.48 13.95 215 300646 34527 79409000
Nail psoriasis 22.48 13.95 19 300842 626 79442901
Cardiac failure chronic 22.47 13.95 7 300854 11128 79432399
Memory impairment 22.36 13.95 292 300569 111442 79332085
Oesophageal carcinoma 22.31 13.95 7 300854 11077 79432450
Eosinophil count increased 22.31 13.95 19 300842 17086 79426441
Dermatitis bullous 22.30 13.95 13 300848 14232 79429295
Ecchymosis 22.25 13.95 15 300846 15191 79428336
Tubulointerstitial nephritis 22.23 13.95 72 300789 38163 79405364
Atrial septal defect acquired 22.22 13.95 7 300854 22 79443505
Glomerular filtration rate decreased 22.15 13.95 32 300829 22670 79420857
Dermatitis contact 22.15 13.95 7 300854 11026 79432501
Oral discomfort 22.10 13.95 84 300777 9676 79433851
Elbow operation 22.05 13.95 15 300846 354 79443173
Dizziness postural 22.02 13.95 8 300853 11541 79431986
Laryngitis 22.00 13.95 119 300742 15920 79427607
Impaired quality of life 21.99 13.95 110 300751 14276 79429251
Nasal congestion 21.88 13.95 184 300677 76368 79367159
Product use in unapproved indication 21.87 13.95 749 300112 249610 79193917
Granuloma 21.84 13.95 75 300786 8222 79435305
Herpes zoster 21.83 13.95 482 300379 92601 79350926
Caesarean section 21.76 13.95 10 300851 12525 79431002
Pulmonary alveolar haemorrhage 21.73 13.95 8 300853 11449 79432078
Liver function test abnormal 21.72 13.95 353 300508 64122 79379405
Feeling hot 21.72 13.95 134 300727 59600 79383927
Dry eye 21.70 13.95 224 300637 36707 79406820
Squamous cell carcinoma of skin 21.69 13.95 13 300848 14020 79429507
Extra dose administered 21.67 13.95 3 300858 8412 79435115
Coronary artery stenosis 21.61 13.95 10 300851 12474 79431053
Demyelination 21.54 13.95 73 300788 7950 79435577
Haemorrhoids 21.32 13.95 49 300812 29079 79414448
Sacroiliitis 21.19 13.95 45 300816 3709 79439818
Gastrointestinal toxicity 21.08 13.95 73 300788 8036 79435491
Brain natriuretic peptide increased 21.07 13.95 4 300857 8896 79434631
Skin irritation 21.07 13.95 8 300853 11232 79432295
Viral infection 21.06 13.95 87 300774 42929 79400598
Retinal haemorrhage 21.00 13.95 3 300858 8214 79435313
Orthopnoea 20.93 13.95 6 300855 10067 79433460
Peripheral ischaemia 20.86 13.95 5 300856 9452 79434075
Soft tissue swelling 20.84 13.95 27 300834 1474 79442053
Staphylococcal bacteraemia 20.82 13.95 10 300851 12208 79431319
Hiccups 20.80 13.95 6 300855 10025 79433502
Extrapulmonary tuberculosis 20.79 13.95 15 300846 390 79443137
Xyphoid retraction 20.72 13.95 11 300850 162 79443365
Deep vein thrombosis 20.68 13.95 326 300535 120593 79322934
Gastroenteritis 20.65 13.95 63 300798 34019 79409508
Allergy to chemicals 20.60 13.95 36 300825 2566 79440961
Eyelid ptosis 20.47 13.95 8 300853 11036 79432491
Epigastric discomfort 20.46 13.95 71 300790 7825 79435702
Transaminases increased 20.45 13.95 113 300748 51630 79391897
Nystagmus 20.39 13.95 6 300855 9898 79433629
Enterocolitis 20.33 13.95 15 300846 14497 79429030
Rash papular 20.31 13.95 32 300829 21884 79421643
Mononucleosis syndrome 20.28 13.95 10 300851 125 79443402
Chronic sinusitis 20.23 13.95 12 300849 13014 79430513
Blood calcium increased 20.17 13.95 7 300854 10393 79433134
Rhinovirus infection 20.10 13.95 3 300858 7950 79435577
Granulocytopenia 20.03 13.95 9 300852 11422 79432105
Leukoencephalopathy 20.02 13.95 3 300858 7926 79435601
Adenoiditis 20.01 13.95 7 300854 33 79443494
Confusional state 19.77 13.95 989 299872 317008 79126519
Spondyloarthropathy 19.77 13.95 22 300839 1023 79442504
Blood pressure systolic abnormal 19.76 13.95 122 300739 17125 79426402
Encephalitis 19.74 13.95 16 300845 14744 79428783
Stress at work 19.69 13.95 23 300838 1128 79442399
Blood pressure diastolic abnormal 19.65 13.95 132 300729 19070 79424457
Respiratory rate increased 19.58 13.95 32 300829 21568 79421959
Immunodeficiency 19.56 13.95 145 300716 21623 79421904
Polyglandular disorder 19.52 13.95 7 300854 36 79443491
Upper respiratory tract infection 19.46 13.95 235 300626 90933 79352594
Sexual dysfunction 19.45 13.95 3 300858 7760 79435767
Hyperreflexia 19.36 13.95 4 300857 8381 79435146
Hyperaesthesia 19.35 13.95 11 300850 12211 79431316
Partial seizures 19.31 13.95 5 300856 8973 79434554
Iritis 19.25 13.95 44 300817 3811 79439716
Knee deformity 19.24 13.95 24 300837 1261 79442266
Thinking abnormal 19.24 13.95 13 300848 13148 79430379
Post procedural complication 19.18 13.95 38 300823 23791 79419736
Eyelid exfoliation 19.16 13.95 10 300851 142 79443385
Shoulder operation 19.15 13.95 36 300825 2716 79440811
Eye pruritus 19.10 13.95 30 300831 20540 79422987
Necrosis 19.10 13.95 6 300855 9487 79434040
Abortion spontaneous 19.00 13.95 53 300808 29454 79414073
Gait disturbance 18.93 13.95 961 299900 206545 79236982
Pathological fracture 18.93 13.95 8 300853 10529 79432998
Hepatic cancer 18.91 13.95 8 300853 10521 79433006
Rib fracture 18.90 13.95 49 300812 27898 79415629
Pneumothorax 18.89 13.95 50 300811 28273 79415254
Solar urticaria 18.87 13.95 9 300852 104 79443423
Phlebitis 18.83 13.95 5 300856 8825 79434702
Mixed liver injury 18.83 13.95 3 300858 7575 79435952
Sinus disorder 18.80 13.95 35 300826 22429 79421098
Potentiating drug interaction 18.80 13.95 5 300856 8814 79434713
Tender joint count 18.78 13.95 11 300850 198 79443329
Brain injury 18.76 13.95 10 300851 11507 79432020
Pleuritic pain 18.73 13.95 82 300779 10070 79433457
Cholecystitis acute 18.72 13.95 14 300847 13437 79430090
Fear 18.63 13.95 34 300827 21952 79421575
Myasthenia gravis 18.51 13.95 8 300853 10391 79433136
Metastases to lymph nodes 18.51 13.95 8 300853 10389 79433138
Overlap syndrome 18.42 13.95 21 300840 1003 79442524
Bone density increased 18.41 13.95 19 300842 810 79442717
Bacterial test positive 18.39 13.95 3 300858 7446 79436081
Facial paralysis 18.38 13.95 32 300829 21040 79422487
Ischaemia 18.35 13.95 4 300857 8071 79435456
International normalised ratio decreased 18.33 13.95 4 300857 8066 79435461
Cholecystitis 18.25 13.95 35 300826 22177 79421350
Oesophageal candidiasis 18.24 13.95 6 300855 9212 79434315
Dental caries 18.20 13.95 11 300850 11809 79431718
Cholangitis 18.17 13.95 13 300848 12763 79430764
Bone marrow oedema 18.09 13.95 27 300834 1684 79441843
Metabolic disorder 18.09 13.95 6 300855 9164 79434363
Human anti-human antibody test 18.00 13.95 14 300847 409 79443118
Injection site haemorrhage 17.99 13.95 50 300811 27820 79415707
Nightmare 17.75 13.95 45 300816 25816 79417711
Metabolic surgery 17.69 13.95 22 300839 1152 79442375
Mucormycosis 17.68 13.95 5 300856 8464 79435063
Hypertonia 17.66 13.95 3 300858 7229 79436298
Protein urine present 17.66 13.95 8 300853 10104 79433423
Coronary artery occlusion 17.65 13.95 19 300842 15296 79428231
Mood altered 17.57 13.95 25 300836 17822 79425705
Haematochezia 17.55 13.95 229 300632 87416 79356111
Aplasia pure red cell 17.48 13.95 4 300857 7806 79435721
Paronychia 17.47 13.95 4 300857 7804 79435723
Sensory loss 17.47 13.95 14 300847 12977 79430550
Rheumatoid factor quantitative increased 17.46 13.95 5 300856 10 79443517
Ureterocele 17.46 13.95 5 300856 10 79443517
Premature labour 17.43 13.95 5 300856 8385 79435142
Skin reaction 17.38 13.95 112 300749 15956 79427571
Injection site mass 17.29 13.95 31 300830 20153 79423374
Venous thrombosis 17.27 13.95 3 300858 7113 79436414
Neutropenic sepsis 17.14 13.95 49 300812 27015 79416512
Rash macular 17.09 13.95 54 300807 28845 79414682
Azotaemia 17.07 13.95 5 300856 8271 79435256
Thyroid disorder 17.03 13.95 101 300760 13978 79429549
Supraventricular extrasystoles 16.84 13.95 3 300858 6984 79436543
Glaucoma 16.84 13.95 130 300731 19631 79423896
Carotid artery stenosis 16.81 13.95 6 300855 8752 79434775
Disability assessment scale score increased 16.75 13.95 39 300822 3419 79440108
Endocrine ophthalmopathy 16.74 13.95 17 300844 711 79442816
Mycobacterium marinum infection 16.73 13.95 14 300847 455 79443072
Product storage error 16.71 13.95 22 300839 16204 79427323
Sinus congestion 16.65 13.95 31 300830 19865 79423662
Retinal detachment 16.65 13.95 7 300854 9240 79434287
Hydronephrosis 16.64 13.95 25 300836 17429 79426098
Kidney infection 16.62 13.95 36 300825 21815 79421712
Dysphonia 16.57 13.95 136 300725 56736 79386791
Ossicle disorder 16.55 13.95 6 300855 32 79443495
Muscle atrophy 16.54 13.95 11 300850 11221 79432306
Fibrin D dimer increased 16.49 13.95 6 300855 8648 79434879
Body temperature increased 16.48 13.95 99 300762 44321 79399206
Prostate cancer 16.46 13.95 67 300794 33201 79410326
Needle issue 16.46 13.95 15 300846 13053 79430474
Ganglioneuroma 16.41 13.95 9 300852 142 79443385
Bladder transitional cell carcinoma 16.41 13.95 33 300828 2617 79440910
Vaginal discharge 16.35 13.95 4 300857 7459 79436068
Neoplasm 16.25 13.95 7 300854 9109 79434418
Bronchitis 16.24 13.95 372 300489 130272 79313255
Cardiopulmonary failure 16.22 13.95 3 300858 6798 79436729
Catheter site infection 16.20 13.95 3 300858 6792 79436735
Hepatomegaly 16.16 13.95 29 300832 18845 79424682
Splenic embolism 16.06 13.95 10 300851 202 79443325
Skin discolouration 16.00 13.95 90 300771 40944 79402583
Skin haemorrhage 16.00 13.95 13 300848 11968 79431559
Urticarial vasculitis 15.98 13.95 15 300846 569 79442958
Gastric haemorrhage 15.91 13.95 20 300841 15030 79428497
Red blood cell sedimentation rate decreased 15.90 13.95 11 300850 267 79443260
Refusal of treatment by patient 15.88 13.95 7 300854 8984 79434543
Anti-neutrophil cytoplasmic antibody positive vasculitis 15.87 13.95 40 300821 3689 79439838
Anti-saccharomyces cerevisiae antibody 15.80 13.95 5 300856 16 79443511
Blood culture positive 15.80 13.95 6 300855 8423 79435104
Hypoaesthesia oral 15.75 13.95 18 300843 14106 79429421
Hypercapnia 15.71 13.95 7 300854 8928 79434599
Wound infection fungal 15.55 13.95 10 300851 214 79443313
Pemphigoid 15.53 13.95 21 300840 15294 79428233
Erysipelas 15.48 13.95 11 300850 10839 79432688
Renal mass 15.46 13.95 37 300824 3303 79440224
Effusion 15.45 13.95 29 300832 2185 79441342
Food allergy 15.41 13.95 11 300850 10813 79432714
Cystitis 15.41 13.95 126 300735 52606 79390921
Euphoric mood 15.34 13.95 5 300856 7721 79435806
Injection site induration 15.31 13.95 9 300852 9810 79433717
Peripheral arterial occlusive disease 15.27 13.95 6 300855 8252 79435275
Monocyte count increased 15.23 13.95 80 300781 10581 79432946
Peripheral sensory neuropathy 15.21 13.95 16 300845 13017 79430510
Portal hypertension 15.21 13.95 4 300857 7104 79436423
Proteinuria 15.13 13.95 67 300794 32435 79411092
Multiple sclerosis 15.12 13.95 39 300822 22243 79421284
Carotid artery occlusion 15.09 13.95 5 300856 7642 79435885
Oligoarthritis 15.02 13.95 16 300845 708 79442819
Device breakage 15 13.95 11 300850 10664 79432863
Blood thyroid stimulating hormone increased 15.00 13.95 9 300852 9699 79433828
Stress 14.97 13.95 400 300461 79212 79364315
Depressive symptom 14.97 13.95 3 300858 6420 79437107
Injection site reaction 14.91 13.95 290 300571 54495 79389032
Pneumatosis intestinalis 14.88 13.95 3 300858 6394 79437133
Heart rate irregular 14.83 13.95 68 300793 32611 79410916
Thrombotic thrombocytopenic purpura 14.81 13.95 3 300858 6373 79437154
Non-small cell lung cancer 14.76 13.95 3 300858 6357 79437170
Glucose tolerance impaired 14.75 13.95 6 300855 8078 79435449
Large intestine perforation 14.74 13.95 20 300841 14547 79428980
Tachyarrhythmia 14.74 13.95 4 300857 6958 79436569
Back pain 14.74 13.95 969 299892 303211 79140316
Hepatic necrosis 14.68 13.95 8 300853 9092 79434435
Clear cell renal cell carcinoma 14.68 13.95 31 300830 2545 79440982
Arthritis bacterial 14.66 13.95 71 300790 9095 79434432
Foetal death 14.62 13.95 6 300855 8038 79435489
Hallucinations, mixed 14.54 13.95 4 300857 6895 79436632
Diverticulum 14.53 13.95 21 300840 14875 79428652
Eye movement disorder 14.52 13.95 6 300855 8005 79435522
Fluid intake reduced 14.52 13.95 3 300858 6285 79437242
Diaphragmatic injury 14.49 13.95 8 300853 128 79443399
Occult blood positive 14.49 13.95 4 300857 6879 79436648
Concomitant disease aggravated 14.45 13.95 17 300844 13150 79430377
Device related sepsis 14.36 13.95 3 300858 6237 79437290
Major depression 14.33 13.95 8 300853 8972 79434555
Diabetic neuropathy 14.28 13.95 3 300858 6213 79437314
Inflammatory marker increased 14.27 13.95 79 300782 10661 79432866
Seasonal allergy 14.23 13.95 25 300836 16381 79427146
Bone tuberculosis 14.17 13.95 14 300847 566 79442961
Polychondritis 14.17 13.95 14 300847 566 79442961
Vaginal haematoma 14.16 13.95 8 300853 134 79443393
Pseudomonal sepsis 14.15 13.95 3 300858 6171 79437356
Renal cyst 14.14 13.95 21 300840 14711 79428816
Nail operation 14.09 13.95 15 300846 663 79442864
Personality disorder 14.05 13.95 3 300858 6143 79437384
Aphonia 14.01 13.95 11 300850 10301 79433226
Diffuse idiopathic skeletal hyperostosis 13.99 13.95 6 300855 53 79443474
Gardner-Diamond syndrome 13.97 13.95 4 300857 8 79443519
Infusion site swelling 13.97 13.95 6 300855 7820 79435707
Arteriospasm coronary 13.96 13.95 4 300857 6712 79436815

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A07EC01 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFLAMMATORY AGENTS
Aminosalicylic acid and similar agents
FDA CS M0000971 Aminosalicylic Acids
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory agent
CHEBI has role CHEBI:35441 antiinfective agents
CHEBI has role CHEBI:55324 gastrointestinal drugs
CHEBI has role CHEBI:76797 RX:glutathione R-transferase inhibitors
CHEBI has role CHEBI:88188 allergenic drug
CHEBI has role CHEBI:173085 ferroptosis inducers
FDA EPC N0000175781 Aminosalicylate

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ulcerative colitis indication 64766004 DOID:8577
Rheumatoid arthritis indication 69896004 DOID:7148
Juvenile rheumatoid arthritis indication 410795001
Collagenous colitis off-label use 19311003 DOID:0060183
Psoriasis with arthropathy off-label use 33339001
Crohn's disease off-label use 34000006
Systemic sclerosis off-label use 89155008 DOID:418
Urinary tract obstruction contraindication 7163005 DOID:5200
Kidney disease contraindication 90708001 DOID:557
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Gastrointestinal obstruction contraindication 126765001
Asthma contraindication 195967001 DOID:2841
Disease of liver contraindication 235856003 DOID:409
Neutropenic disorder contraindication 303011007 DOID:1227
Aplastic anemia contraindication 306058006 DOID:12449
Porphyria contraindication 418470004
Slow acetylator due to N-acetyltransferase enzyme variant contraindication 425079005




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.28 acidic
pKa2 8.93 acidic
pKa3 11.45 acidic
pKa4 1.48 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Cyclooxygenase Enzyme INHIBITOR CHEMBL CHEMBL
Arachidonate 5-lipoxygenase Enzyme INHIBITOR WOMBAT-PK CHEMBL
Carbonic anhydrase 2 Enzyme Ki 5.06 CHEMBL
ATP-binding cassette sub-family G member 2 Transporter IC50 6.34 CHEMBL
Carbonic anhydrase 1 Enzyme Ki 5.16 CHEMBL
Acetyl-CoA acetyltransferase, mitochondrial Enzyme WOMBAT-PK
Cystine/glutamate transporter Transporter IC50 4.52 CHEMBL
Caspase-1 Enzyme IC50 4.54 DRUG MATRIX
Flavin reductase (NADPH) Enzyme Kd 6.36 CHEMBL
Interstitial collagenase Enzyme IC50 4.63 DRUG MATRIX
Proton-coupled folate transporter Transporter INHIBITOR IC50 4.20 IUPHAR
Mitogen-activated protein kinase 1 Kinase IC50 5.20 DRUG MATRIX
Sodium/bile acid cotransporter Transporter IC50 5.02 CHEMBL
Thromboxane-A synthase Enzyme IC50 4.71 DRUG MATRIX
Bifunctional purine biosynthesis protein PURH Enzyme Ki 4.66 CHEMBL
Multidrug resistance protein 1 Transporter EC50 6.04 CHEMBL
Androgen receptor Transcription factor Ki 4.53 DRUG MATRIX
Aldose reductase Enzyme IC50 4.77 DRUG MATRIX
Replicase polyprotein 1ab Unclassified Kd 5.12 CHEMBL

External reference:

IDSource
4017897 VUID
N0000146249 NUI
D00448 KEGG_DRUG
4017897 VANDF
4019494 VANDF
C0036078 UMLSCUI
CHEBI:9334 CHEBI
CHEBI:6775 CHEBI
SAS PDB_CHEM_ID
CHEMBL421 ChEMBL_ID
D012460 MESH_DESCRIPTOR_UI
DB00795 DRUGBANK_ID
5339 PUBCHEM_CID
4840 IUPHAR_LIGAND_ID
2210 INN_ID
3XC8GUZ6CB UNII
202770 RXNORM
2061 MMSL
37855 MMSL
37856 MMSL
3946 MMSL
5056 MMSL
5528 MMSL
663 MMSL
d00379 MMSL
d01031 MMSL
001600 NDDF
002832 NDDF
387248006 SNOMEDCT_US
387501005 SNOMEDCT_US
45844004 SNOMEDCT_US
86977007 SNOMEDCT_US
C0127615 UMLSCUI
DB00244 DRUGBANK_ID
4075 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Azulfidine HUMAN PRESCRIPTION DRUG LABEL 1 0013-0101 TABLET 500 mg ORAL NDA 26 sections
Azulfidine HUMAN PRESCRIPTION DRUG LABEL 1 0013-0101 TABLET 500 mg ORAL NDA 26 sections
Azulfidine EN-tabs HUMAN PRESCRIPTION DRUG LABEL 1 0013-0102 TABLET, DELAYED RELEASE 500 mg ORAL NDA 24 sections
Azulfidine EN-tabs HUMAN PRESCRIPTION DRUG LABEL 1 0013-0102 TABLET, DELAYED RELEASE 500 mg ORAL NDA 24 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3234 TABLET 500 mg ORAL ANDA 23 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 0591-0796 TABLET 500 mg ORAL ANDA 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 0591-0796 TABLET 500 mg ORAL ANDA 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 0591-0796 TABLET 500 mg ORAL ANDA 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 10544-288 TABLET 500 mg ORAL ANDA 29 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 23155-019 TABLET 500 mg ORAL ANDA 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 23155-019 TABLET 500 mg ORAL ANDA 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 33261-756 TABLET 500 mg ORAL ANDA 29 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 43353-495 TABLET 500 mg ORAL NDA AUTHORIZED GENERIC 27 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 50090-0086 TABLET 500 mg ORAL NDA AUTHORIZED GENERIC 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 50090-0086 TABLET 500 mg ORAL NDA AUTHORIZED GENERIC 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 50090-2013 TABLET 500 mg ORAL ANDA 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 50090-2013 TABLET 500 mg ORAL ANDA 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 50090-2013 TABLET 500 mg ORAL ANDA 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 50268-730 TABLET 500 mg ORAL ANDA 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 59762-0104 TABLET, DELAYED RELEASE 500 mg ORAL NDA AUTHORIZED GENERIC 26 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 59762-0104 TABLET, DELAYED RELEASE 500 mg ORAL NDA AUTHORIZED GENERIC 26 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 59762-5000 TABLET 500 mg ORAL NDA AUTHORIZED GENERIC 26 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 59762-5000 TABLET 500 mg ORAL NDA AUTHORIZED GENERIC 26 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 62135-960 TABLET 500 mg ORAL ANDA 14 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 62135-960 TABLET 500 mg ORAL ANDA 14 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 63629-5688 TABLET 500 mg ORAL ANDA 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 63629-5688 TABLET 500 mg ORAL ANDA 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 63629-9715 TABLET 500 mg ORAL ANDA 23 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 68071-4215 TABLET 500 mg ORAL ANDA 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 70518-0185 TABLET 500 mg ORAL ANDA 25 sections