Stem definition | Drug id | CAS RN |
---|---|---|
anti-infectives, sulfonamides | 2512 | 144-82-1 |
Dose | Unit | Route |
---|---|---|
4 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 4 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.61 mg/mL | Bocci G, Oprea TI, Benet LZ |
EoM (Fraction excreted unchanged in urine) | 86 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 211.38 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Date | Agency | Company | Orphan |
---|---|---|---|
Oct. 28, 1953 | FDA |
None
None
None
None
Source | Code | Description |
---|---|---|
ATC | B05CA04 | BLOOD AND BLOOD FORMING ORGANS BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS IRRIGATING SOLUTIONS Antiinfectives |
ATC | D06BA04 | DERMATOLOGICALS ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE CHEMOTHERAPEUTICS FOR TOPICAL USE Sulfonamides |
ATC | J01EB02 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE SULFONAMIDES AND TRIMETHOPRIM Short-acting sulfonamides |
ATC | S01AB01 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Sulfonamides |
MeSH PA | D000890 | Anti-Infective Agents |
CHEBI has role | CHEBI:33281 | antibiotics |
CHEBI has role | CHEBI:35441 | antiinfective agents |
CHEBI has role | CHEBI:50502 | dihydropteroate synthase inhibitors |
CHEBI has role | CHEBI:88188 | allergenic drug |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Acute otitis media | indication | 3110003 | |
Haemophilus Influenzae Acute Otitis Media | indication | 19021002 | |
Shigellosis | indication | 36188001 | |
Klebsiella cystitis | indication | 60867007 | |
Escherichia coli urinary tract infection | indication | 301011002 | |
Proteus urinary tract infection | indication | 301012009 | |
Bacterial urinary infection | indication | 312124009 | |
Infective otitis media | indication | 312218008 | |
Pneumocystosis jiroveci pneumonia | indication | 415125002 | DOID:11339 |
Pneumocystis Carinii Pneumonia Prevention | indication | ||
Morganella Morganii Urinary Tract Infection | indication | ||
Streptococcus Pneumoniae Chronic Bronchitis | indication | ||
Haemophilus Influenzae Chronic Bronchitis | indication | ||
Renal tubular acidosis | contraindication | 1776003 | DOID:14219 |
Respiratory acidosis | contraindication | 12326000 | |
Hyperkalemia | contraindication | 14140009 | |
Metabolic acidosis, normal anion gap, acidifying salts | contraindication | 18104000 | |
Glomerulonephritis | contraindication | 36171008 | DOID:2921 |
Acute hepatitis | contraindication | 37871000 | |
Diabetes mellitus type 2 | contraindication | 44054006 | DOID:9352 |
Uremia | contraindication | 44730006 | DOID:4676 |
Diabetes mellitus type 1 | contraindication | 46635009 | DOID:9744 |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Decreased respiratory function | contraindication | 80954004 | |
Hyponatremia | contraindication | 89627008 | |
Gout | contraindication | 90560007 | DOID:13189 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Anemia due to enzyme deficiency | contraindication | 111577008 | |
Deficiency of glucose-6-phosphate dehydrogenase | contraindication | 124134002 | DOID:2862 |
Disease of blood AND/OR blood-forming organ | contraindication | 191124002 | DOID:74 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Disorder of electrolytes | contraindication | 237840007 | |
Pregnancy, function | contraindication | 289908002 | |
Primary adrenocortical insufficiency | contraindication | 373662000 | |
Pseudomembranous enterocolitis | contraindication | 397683000 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Recurrent Calcium Renal Calculi | contraindication |
Species | Use | Relation |
---|---|---|
Cats | Urinary tract infections | Indication |
Cats | Management of complications resulting from surgical manipulations of the urinary tract | Indication |
Dogs | Urinary tract infections | Indication |
Dogs | Management of complications resulting from surgical manipulations of the urinary tract | Indication |
Product | Applicant | Ingredients |
---|---|---|
Mesulfin Tablets | Zoetis Inc. | 2 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 5.34 | acidic |
pKa2 | 2.81 | Basic |
pKa3 | 2.17 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Dihydropteroate synthase | Enzyme | INHIBITOR | WOMBAT-PK | CHEMBL |
ID | Source |
---|---|
4018493 | VUID |
N0000146815 | NUI |
D00870 | KEGG_DRUG |
4018493 | VANDF |
C0038687 | UMLSCUI |
CHEBI:9331 | CHEBI |
CHEMBL1191 | ChEMBL_ID |
DB00576 | DRUGBANK_ID |
D013419 | MESH_DESCRIPTOR_UI |
5328 | PUBCHEM_CID |
12683 | IUPHAR_LIGAND_ID |
529 | INN_ID |
25W8454H16 | UNII |
10179 | RXNORM |
5525 | MMSL |
d01090 | MMSL |
002822 | NDDF |
387389006 | SNOMEDCT_US |
70254000 | SNOMEDCT_US |
None