sulconazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
systemic antifungal agents, miconazole derivatives 2495 61318-90-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sulconazole mononitrate
  • sulconazole
  • sulconazole nitrate
  • Molecular weight: 397.74
  • Formula: C18H15Cl3N2S
  • CLOGP: 6.27
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 0
  • TPSA: 17.82
  • ALOGS: -5.49
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Aug. 30, 1985 FDA RANBAXY

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D01AC09 DERMATOLOGICALS
ANTIFUNGALS FOR DERMATOLOGICAL USE
ANTIFUNGALS FOR TOPICAL USE
Imidazole and triazole derivatives
FDA CS M0002083 Azoles
FDA EPC N0000175487 Azole Antifungal
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Tinea pedis indication 6020002 DOID:12403
Pityriasis versicolor indication 56454009 DOID:9060
Tinea corporis indication 84849002
Tinea cruris indication 399029005




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.02 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Cytochrome P450 3A4 Enzyme IC50 7.16 DRUG MATRIX
Sodium-dependent serotonin transporter Transporter Ki 7.13 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 5.70 DRUG MATRIX
5-hydroxytryptamine receptor 2A GPCR Ki 5.95 DRUG MATRIX
5-hydroxytryptamine receptor 2B GPCR Ki 5.72 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 5.84 DRUG MATRIX
Alpha-2B adrenergic receptor GPCR Ki 5.79 DRUG MATRIX
D(3) dopamine receptor GPCR Ki 5.98 DRUG MATRIX
Muscarinic acetylcholine receptor M1 GPCR Ki 6.05 DRUG MATRIX
Muscarinic acetylcholine receptor M3 GPCR Ki 6.14 DRUG MATRIX
Muscarinic acetylcholine receptor M4 GPCR Ki 6.26 DRUG MATRIX
Muscarinic acetylcholine receptor M5 GPCR Ki 5.73 DRUG MATRIX
Alpha-2C adrenergic receptor GPCR Ki 6.14 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 5.86 DRUG MATRIX
Cytochrome P450 2D6 Enzyme IC50 6.10 DRUG MATRIX
Adenosine receptor A3 GPCR Ki 5.83 DRUG MATRIX
Cytochrome P450 2C9 Enzyme IC50 6.70 DRUG MATRIX
Cytochrome P450 1A2 Enzyme IC50 6.22 DRUG MATRIX
Cytochrome P450 2C19 Enzyme IC50 7.80 DRUG MATRIX
Alkaline phosphatase, tissue-nonspecific isozyme Enzyme EC50 4.22 CHEMBL
Tyrosine-protein kinase Fyn Kinase IC50 5.43 DRUG MATRIX
Thromboxane-A synthase Enzyme IC50 6.74 DRUG MATRIX
Bile acid receptor Nuclear hormone receptor IC50 5.16 CHEMBL
Indoleamine 2,3-dioxygenase 1 Enzyme IC50 5.19 CHEMBL
Substance-K receptor GPCR Ki 5.78 DRUG MATRIX
Malate dehydrogenase cytoplasmic Enzyme IC50 4.70 CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 5.82 DRUG MATRIX
Lanosterol 14-alpha demethylase Enzyme INHIBITOR CHEMBL CHEMBL
Beta-lactamase Enzyme IC50 4.85 CHEMBL
Indoleamine 2,3-dioxygenase 2 Enzyme IC50 5 CHEMBL
Indoleamine 2,3-dioxygenase 1 Enzyme IC50 4.53 CHEMBL

External reference:

IDSource
4019938 VUID
N0000148023 NUI
D00886 KEGG_DRUG
61318-91-0 SECONDARY_CAS_RN
4019499 VANDF
4019938 VANDF
C0075503 UMLSCUI
CHEBI:9325 CHEBI
CHEMBL1221 ChEMBL_ID
CHEMBL1200348 ChEMBL_ID
DB06820 DRUGBANK_ID
C033308 MESH_SUPPLEMENTAL_RECORD_UI
5318 PUBCHEM_CID
4332 INN_ID
5D9HAA5Q5S UNII
37319 RXNORM
5521 MMSL
002933 NDDF
004964 NDDF
108920000 SNOMEDCT_US
108921001 SNOMEDCT_US
373448004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Exelderm HUMAN PRESCRIPTION DRUG LABEL 1 69489-711 CREAM 10 mg TOPICAL NDA 18 sections
Exelderm HUMAN PRESCRIPTION DRUG LABEL 1 69489-721 SOLUTION 10 mg TOPICAL NDA 17 sections
Sulconazole Nitrate HUMAN PRESCRIPTION DRUG LABEL 1 72143-311 CREAM 10 mg TOPICAL NDA 18 sections
Sulconazole Nitrate HUMAN PRESCRIPTION DRUG LABEL 1 72143-321 SOLUTION 10 mg TOPICAL NDA 17 sections