All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

sulconazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
systemic antifungal agents, miconazole derivatives	2495	61318-90-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: sulconazole mononitrate sulconazole sulconazole nitrate	Molecular weight: 397.74 Formula: C18H15Cl3N2S CLOGP: 6.27 LIPINSKI: 1 HAC: 2 HDO: 0 TPSA: 17.82 ALOGS: -5.49 ROTB: 6 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Aug. 30, 1985	FDA	RANBAXY

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D01AC09	DERMATOLOGICALS ANTIFUNGALS FOR DERMATOLOGICAL USE ANTIFUNGALS FOR TOPICAL USE Imidazole and triazole derivatives
FDA CS	M0002083	Azoles
FDA EPC	N0000175487	Azole Antifungal
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000935	Antifungal Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Tinea pedis	indication	6020002	DOID:12403
Pityriasis versicolor	indication	56454009	DOID:9060
Tinea corporis	indication	84849002
Tinea cruris	indication	399029005

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	5.02	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN		Ki	5.82		DRUG MATRIX
Cytochrome P450 3A4	Enzyme	P08684	CP3A4_HUMAN		IC50	7.16		DRUG MATRIX
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN		Ki	7.13		DRUG MATRIX
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN		Ki	5.70		DRUG MATRIX
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN		Ki	5.95		DRUG MATRIX
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	5.72		DRUG MATRIX
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN		Ki	5.84		DRUG MATRIX
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN		Ki	5.79		DRUG MATRIX
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN		Ki	5.98		DRUG MATRIX
Muscarinic acetylcholine receptor M1	GPCR	P11229	ACM1_HUMAN		Ki	6.05		DRUG MATRIX
Muscarinic acetylcholine receptor M3	GPCR	P20309	ACM3_HUMAN		Ki	6.14		DRUG MATRIX
Muscarinic acetylcholine receptor M5	GPCR	P08912	ACM5_HUMAN		Ki	5.73		DRUG MATRIX
Alpha-2C adrenergic receptor	GPCR	P18825	ADA2C_HUMAN		Ki	6.14		DRUG MATRIX
Sodium-dependent dopamine transporter	Transporter	Q01959	SC6A3_HUMAN		Ki	5.86		DRUG MATRIX
Cytochrome P450 2D6	Enzyme	P10635	CP2D6_HUMAN		IC50	6.10		DRUG MATRIX
Adenosine receptor A3	GPCR	P0DMS8	AA3R_HUMAN		Ki	5.83		DRUG MATRIX
Cytochrome P450 2C9	Enzyme	P11712	CP2C9_HUMAN		IC50	6.70		DRUG MATRIX
Cytochrome P450 1A2	Enzyme	P05177	CP1A2_HUMAN		IC50	6.22		DRUG MATRIX
Cytochrome P450 2C19	Enzyme	P33261	CP2CJ_HUMAN		IC50	7.80		DRUG MATRIX
Alkaline phosphatase, tissue-nonspecific isozyme	Enzyme	P05186	PPBT_HUMAN		EC50	4.22		CHEMBL
Tyrosine-protein kinase Fyn	Kinase	P06241	FYN_HUMAN		IC50	5.43		DRUG MATRIX
Thromboxane-A synthase	Enzyme	P24557	THAS_HUMAN		IC50	6.74		DRUG MATRIX
Bile acid receptor	Nuclear hormone receptor	Q96RI1	NR1H4_HUMAN		IC50	5.16		CHEMBL
Indoleamine 2,3-dioxygenase 1	Enzyme	P14902	I23O1_HUMAN		IC50	5.19		CHEMBL
Substance-K receptor	GPCR	P21452	NK2R_HUMAN		Ki	5.78		DRUG MATRIX
Malate dehydrogenase cytoplasmic	Enzyme	P40925	MDHC_HUMAN		IC50	4.70		CHEMBL
Muscarinic acetylcholine receptor M4	GPCR	P08173	ACM4_HUMAN		Ki	6.26		DRUG MATRIX
Lanosterol 14-alpha demethylase	Enzyme		CP51_CANAL	INHIBITOR				CHEMBL	CHEMBL
Beta-lactamase	Enzyme		AMPC_ECOLI		IC50	4.85		CHEMBL
Indoleamine 2,3-dioxygenase 2	Enzyme		I23O2_MOUSE		IC50	5		CHEMBL
Indoleamine 2,3-dioxygenase 1	Enzyme		I23O1_MOUSE		IC50	4.53		CHEMBL

External reference:

ID	Source
4019938	VUID
N0000148023	NUI
D00886	KEGG_DRUG
61318-91-0	SECONDARY_CAS_RN
4019499	VANDF
4019938	VANDF
C0075503	UMLSCUI
CHEBI:9325	CHEBI
CHEMBL1221	ChEMBL_ID
CHEMBL1200348	ChEMBL_ID
DB06820	DRUGBANK_ID
C033308	MESH_SUPPLEMENTAL_RECORD_UI
5318	PUBCHEM_CID
4332	INN_ID
5D9HAA5Q5S	UNII
37319	RXNORM
358697	MMSL
5521	MMSL
002933	NDDF
004964	NDDF
108920000	SNOMEDCT_US
108921001	SNOMEDCT_US
373448004	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Exelderm	HUMAN PRESCRIPTION DRUG LABEL	1	69489-711	CREAM	10 mg	TOPICAL	NDA	18 sections
Exelderm	HUMAN PRESCRIPTION DRUG LABEL	1	69489-711	CREAM	10 mg	TOPICAL	NDA	18 sections
Exelderm	HUMAN PRESCRIPTION DRUG LABEL	1	69489-721	SOLUTION	10 mg	TOPICAL	NDA	17 sections
Exelderm	HUMAN PRESCRIPTION DRUG LABEL	1	69489-721	SOLUTION	10 mg	TOPICAL	NDA	17 sections
Sulconazole Nitrate	HUMAN PRESCRIPTION DRUG LABEL	1	72143-311	CREAM	10 mg	TOPICAL	NDA	18 sections
Sulconazole Nitrate	HUMAN PRESCRIPTION DRUG LABEL	1	72143-321	SOLUTION	10 mg	TOPICAL	NDA	17 sections