succinic acid Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2487 110-15-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • butanedioic acid
  • succinic acid
A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
  • Molecular weight: 118.09
  • Formula: C4H6O4
  • CLOGP: -0.53
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 74.60
  • ALOGS: 0.25
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:50733 nutraceutical

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Iron deficiency anemia indication 87522002
Peptic ulcer contraindication 13200003 DOID:750
Primary hyperoxaluria contraindication 17901006 DOID:2977
Gastroenteritis contraindication 25374005 DOID:2326
Hemosiderosis contraindication 39011001 DOID:12119
Hemolytic anemia contraindication 61261009 DOID:583
Ulcerative colitis contraindication 64766004 DOID:8577
Anemia due to enzyme deficiency contraindication 111577008
Hb SS disease contraindication 127040003 DOID:10923
Diverticular disease contraindication 397881000
Hemochromatosis contraindication 399187006 DOID:2352
Repeated Blood Transfusions contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.81 acidic
pKa2 5.28 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Egl nine homolog 1 Enzyme IC50 5.52 CHEMBL
Succinate receptor 1 GPCR AGONIST EC50 4.70 IUPHAR

External reference:

IDSource
4028568 VUID
N0000178335 NUI
C0075429 UMLSCUI
60376006 SNOMEDCT_US
NOCODE MMSL
4028568 VANDF
37255 RXNORM
002404 NDDF
AB6MNQ6J6L UNII
1110 PUBCHEM_CID
CHEBI:15741 CHEBI
CHEMBL576 ChEMBL_ID
DB00139 DRUGBANK_ID
SIN PDB_CHEM_ID
D019802 MESH_DESCRIPTOR_UI
3637 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
IROSPAN 24/6 HUMAN PRESCRIPTION DRUG LABEL 20 50967-126 KIT 150 mg None unapproved drug other 9 sections
Viatrexx-Adipose HUMAN PRESCRIPTION DRUG LABEL 10 73069-024 INJECTION 31 [kp_C] INTRAVENOUS unapproved drug other 11 sections
Viatrexx-Cellulite HUMAN PRESCRIPTION DRUG LABEL 10 73069-081 INJECTION 31 [kp_C] INTRAVENOUS unapproved drug other 11 sections
Viatrexx-Facial HUMAN PRESCRIPTION DRUG LABEL 11 73069-164 INJECTION 31 [kp_C] INTRAVENOUS unapproved drug other 11 sections
Viatrexx-Ki-UB HUMAN PRESCRIPTION DRUG LABEL 2 73069-277 INJECTION 31 [kp_C] INTRAVENOUS unapproved drug other 11 sections
Viatrexx-Pigmentation HUMAN PRESCRIPTION DRUG LABEL 9 73069-410 INJECTION 31 [kp_C] INTRAVENOUS unapproved drug other 11 sections
Niferex HUMAN PRESCRIPTION DRUG LABEL 5 75854-321 TABLET 50 mg ORAL unapproved drug other 12 sections