succinic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
2487 110-15-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • butanedioic acid
  • succinic acid
A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
  • Molecular weight: 118.09
  • Formula: C4H6O4
  • CLOGP: -0.53
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 74.60
  • ALOGS: 0.25
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -6.522 Moderate 0.67
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.738 Moderate 0.67
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 2.624 10^-6 cm/s Moderate 0.67
dh-clint Dog hepatocyte intrinsic clearance 0.097 uL/min/10^6 cells Moderate 0.67
dppb Dog plasma protein binding (% unbound) 78.560 % Moderate 0.67
fcs-ppb Fetal calf serum protein binding (% unbound) 94.930 % Moderate 0.67
herg hERG pIC50 3.678 pIC50 Moderate 0.67
hh-clint Human hepatocyte intrinsic clearance 1.279 uL/min/10^6 cells Moderate 0.67
hlm-clint Human liver microsomal intrinsic clearance 4.345 uL/min/mg protein Moderate 0.67
hppb Human plasma protein binding (% unbound) 74.780 % Moderate 0.67
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IKBKB,ITK,JAK1,JAK2,JAK3,KDR,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2,ZAP70 61
kinase-selectivity-class AXL,BRAF,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,MAP2K6,MAP3K14,MAPK7,PRKDC,STK33,TEK,TGFBR1,ZAP70 15
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.264 Moderate 0.67
mh-clint Mouse hepatocyte intrinsic clearance 0.154 Moderate 0.67
mppb Mouse plasma protein binding (% unbound) 99.970 Moderate 0.67
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.002 Moderate 0.67
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 96.930 % Moderate 0.67
rh-clint Rat hepatocyte intrinsic clearance 0.372 uL/min/10^6 cells Moderate 0.67
rh-fuinc Rat hepatocyte fraction unbound in incubation 98.940 % Moderate 0.67
rppb Rat plasma protein binding (% unbound) 98.480 % Moderate 0.67
solubility-dd Solubility at pH 7.4 in DMSO 737.904 uM Moderate 0.67

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:27027 micronutrient
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:50733 nutraceutical
CHEBI has role CHEBI:66987 radiation protective agent
CHEBI has role CHEBI:78675 fundamental metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Iron deficiency anemia indication 87522002
Peptic ulcer contraindication 13200003 DOID:750
Primary hyperoxaluria contraindication 17901006 DOID:2977
Gastroenteritis contraindication 25374005 DOID:2326
Hemosiderosis contraindication 39011001 DOID:12119
Hemolytic anemia contraindication 61261009 DOID:583
Ulcerative colitis contraindication 64766004 DOID:8577
Anemia due to enzyme deficiency contraindication 111577008
Hb SS disease contraindication 127040003 DOID:10923
Diverticular disease contraindication 397881000
Hemochromatosis contraindication 399187006 DOID:2352
Repeated Blood Transfusions contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.81 acidic
pKa2 5.28 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Egl nine homolog 1 Enzyme IC50 5.52 CHEMBL
Succinate receptor 1 GPCR AGONIST EC50 4.70 IUPHAR

External reference:

IDSource
4028568 VUID
N0000178335 NUI
4028568 VANDF
C0075429 UMLSCUI
CHEBI:15741 CHEBI
SIN PDB_CHEM_ID
CHEMBL576 ChEMBL_ID
1110 PUBCHEM_CID
DB00139 DRUGBANK_ID
D019802 MESH_DESCRIPTOR_UI
3637 IUPHAR_LIGAND_ID
AB6MNQ6J6L UNII
37255 RXNORM
NOCODE MMSL
002404 NDDF
60376006 SNOMEDCT_US
AB6MNQ6J6L INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Niferex HUMAN PRESCRIPTION DRUG LABEL 7 75854-344 TABLET 150 mg ORAL unapproved drug other 12 sections