succinic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2487 | 110-15-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
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Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:27027 | trace elements |
| CHEBI has role | CHEBI:49201 | anti-ulcer drugs |
| CHEBI has role | CHEBI:50733 | Dietary Supplement |
| CHEBI has role | CHEBI:66987 | radiation protective drugs |
| CHEBI has role | CHEBI:78675 | fundamental metabolites |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Iron deficiency anemia | indication | 87522002 | |
| Peptic ulcer | contraindication | 13200003 | DOID:750 |
| Primary hyperoxaluria | contraindication | 17901006 | DOID:2977 |
| Gastroenteritis | contraindication | 25374005 | DOID:2326 |
| Hemosiderosis | contraindication | 39011001 | DOID:12119 |
| Hemolytic anemia | contraindication | 61261009 | DOID:583 |
| Ulcerative colitis | contraindication | 64766004 | DOID:8577 |
| Anemia due to enzyme deficiency | contraindication | 111577008 | |
| Hb SS disease | contraindication | 127040003 | DOID:10923 |
| Diverticular disease | contraindication | 397881000 | |
| Hemochromatosis | contraindication | 399187006 | DOID:2352 |
| Repeated Blood Transfusions | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.81 | acidic |
| pKa2 | 5.28 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Egl nine homolog 1 | Enzyme | IC50 | 5.52 | CHEMBL | |||||
| Succinate receptor 1 | GPCR | AGONIST | EC50 | 4.70 | IUPHAR |
External reference:
| ID | Source |
|---|---|
| AB6MNQ6J6L | UNII |
| 4028568 | VUID |
| N0000178335 | NUI |
| 4028568 | VANDF |
| C0075429 | UMLSCUI |
| CHEBI:15741 | CHEBI |
| SIN | PDB_CHEM_ID |
| CHEMBL576 | ChEMBL_ID |
| 1110 | PUBCHEM_CID |
| DB00139 | DRUGBANK_ID |
| D019802 | MESH_DESCRIPTOR_UI |
| 3637 | IUPHAR_LIGAND_ID |
| 37255 | RXNORM |
| NOCODE | MMSL |
| 002404 | NDDF |
| 60376006 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Niferex | HUMAN PRESCRIPTION DRUG LABEL | 9 | 75854-321 | TABLET | 50 mg | ORAL | unapproved drug other | 12 sections |