succinic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2487 110-15-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • butanedioic acid
  • succinic acid
A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
  • Molecular weight: 118.09
  • Formula: C4H6O4
  • CLOGP: -0.53
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 74.60
  • ALOGS: 0.25
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:27027 trace elements
CHEBI has role CHEBI:49201 anti-ulcer drugs
CHEBI has role CHEBI:50733 Dietary Supplement
CHEBI has role CHEBI:66987 radiation protective drugs
CHEBI has role CHEBI:78675 fundamental metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Iron deficiency anemia indication 87522002
Peptic ulcer contraindication 13200003 DOID:750
Primary hyperoxaluria contraindication 17901006 DOID:2977
Gastroenteritis contraindication 25374005 DOID:2326
Hemosiderosis contraindication 39011001 DOID:12119
Hemolytic anemia contraindication 61261009 DOID:583
Ulcerative colitis contraindication 64766004 DOID:8577
Anemia due to enzyme deficiency contraindication 111577008
Hb SS disease contraindication 127040003 DOID:10923
Diverticular disease contraindication 397881000
Hemochromatosis contraindication 399187006 DOID:2352
Repeated Blood Transfusions contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.81 acidic
pKa2 5.28 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Egl nine homolog 1 Enzyme IC50 5.52 CHEMBL
Succinate receptor 1 GPCR AGONIST EC50 4.70 IUPHAR

External reference:

IDSource
AB6MNQ6J6L UNII
4028568 VUID
N0000178335 NUI
4028568 VANDF
C0075429 UMLSCUI
CHEBI:15741 CHEBI
SIN PDB_CHEM_ID
CHEMBL576 ChEMBL_ID
1110 PUBCHEM_CID
DB00139 DRUGBANK_ID
D019802 MESH_DESCRIPTOR_UI
3637 IUPHAR_LIGAND_ID
37255 RXNORM
NOCODE MMSL
002404 NDDF
60376006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Niferex HUMAN PRESCRIPTION DRUG LABEL 9 75854-321 TABLET 50 mg ORAL unapproved drug other 12 sections