strychnine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2484 57-24-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • strychnine
  • Strychnidin-10-one
  • (-)-Strychnine
  • strychnin
  • strychnine hydrochloride
  • strychnine sulfate
  • strychnine HCl
An alkaloid found in the seeds of STRYCHNOS NUX-VOMICA. It is a competitive antagonist at glycine receptors and thus a convulsant. It has been used as an analeptic, in the treatment of nonketotic hyperglycinemia and sleep apnea, and as a rat poison.
  • Molecular weight: 334.42
  • Formula: C21H22N2O2
  • CLOGP: 1.66
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 32.78
  • ALOGS: -2.29
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D002491 Central Nervous System Agents
MeSH PA D000697 Central Nervous System Stimulants
MeSH PA D003292 Convulsants
MeSH PA D018684 Glycine Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D009676 Noxae
MeSH PA D011042 Poisons
CHEBI has role CHEBI:33288 rodenticides
CHEBI has role CHEBI:33289 avicides
CHEBI has role CHEBI:35942 neurotransmitter agents
CHEBI has role CHEBI:48873 anticholinergika
CHEBI has role CHEBI:62754 glycine receptor antagonists

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.32 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Taste receptor type 2 member 46 GPCR AGONIST EC50 6.37 SCIENTIFIC LITERATURE
Muscarinic acetylcholine receptor M2 GPCR ALLOSTERIC MODULATOR Kd 5 IUPHAR
Muscarinic acetylcholine receptor M1 GPCR ALLOSTERIC MODULATOR Kd 5 IUPHAR
Muscarinic acetylcholine receptor M4 GPCR ALLOSTERIC MODULATOR Kd 5 IUPHAR
Muscarinic acetylcholine receptor M3 GPCR ALLOSTERIC MODULATOR Kd 5.70 IUPHAR
Glycine receptor subunit alpha-1 Ion channel IC50 4.70 CHEMBL
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 4.68 CHEMBL

External reference:

IDSource
4019934 VUID
N0000148019 NUI
1421-86-9 SECONDARY_CAS_RN
4019131 VANDF
4019934 VANDF
C0202474 UMLSCUI
CHEBI:28973 CHEBI
SY9 PDB_CHEM_ID
441071 PUBCHEM_CID
CHEMBL227934 ChEMBL_ID
CHEMBL2165710 ChEMBL_ID
CHEMBL2103753 ChEMBL_ID
D013331 MESH_DESCRIPTOR_UI
347 IUPHAR_LIGAND_ID
DB15954 DRUGBANK_ID
H9Y79VD43J UNII
236074 RXNORM
NOCODE MMSL
001377 NDDF
005031 NDDF
005063 NDDF
354051007 SNOMEDCT_US
51200005 SNOMEDCT_US

Pharmaceutical products:

None