spironolactone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
mineralocorticoid receptor (MR, MCR, aldosterone receptor) antagonists 2475 52-01-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • spironolactone
  • abbolactone
  • aldactone
  • aldopur
  • berlactone
  • euteberol
  • quimolactona
  • spirolactone
A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
  • Molecular weight: 416.58
  • Formula: C24H32O4S
  • CLOGP: 2.84
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 60.44
  • ALOGS: -5.32
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
37.50 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.02 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 13.72 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 95.40 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 2.564 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.746 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 61.660 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 46.559 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 23.400 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 27.180 % High 1
herg hERG pIC50 4.485 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 8.511 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 27.164 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 22.830 % High 1
kinase-safety-class ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,JAK3,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MET,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIM2,PRKDC,STK33,SYK,TEK,TTK,ZAP70 40
kinase-selectivity-class EIF2AK3,GRK2 2
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.753 Moderate 0.78
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.448 High 1
mh-clint Mouse hepatocyte intrinsic clearance 252.348 High 1
mppb Mouse plasma protein binding (% unbound) 22.460 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.959 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 26.550 % High 1
rat-kpuu-brain Rat brain Kpuu 0.338 % Moderate 0.78
rh-clint Rat hepatocyte intrinsic clearance 115.345 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 72.410 % High 1
rppb Rat plasma protein binding (% unbound) 16.630 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 129.122 uM High 1

Approvals:

DateAgencyCompanyOrphan
Jan. 21, 1960 FDA GD SEARLE LLC
May 26, 2023 EMA Nova Laboratories Ireland Limited

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperkalaemia 3117.73 9.97 1905 204575 63059 90358908
Acute kidney injury 2035.66 9.97 3037 203443 317350 90104617
Cardiac failure 1456.73 9.97 1507 204973 107989 90313978
Hyponatraemia 1149.92 9.97 1468 205012 132070 90289897
Pemphigus 697.27 9.97 9 206471 326855 90095112
Pulmonary arterial hypertension 687.81 9.97 530 205950 25657 90396310
Synovitis 686.86 9.97 13 206467 329739 90092228
Hypotension 657.56 9.97 1926 204554 323471 90098496
Hand deformity 641.95 9.97 6 206474 296356 90125611
Glossodynia 598.98 9.97 33 206447 321746 90100221
Drug interaction 597.78 9.97 1677 204803 274776 90147191
Right ventricular failure 594.46 9.97 429 206051 18776 90403191
Systemic lupus erythematosus 588.22 9.97 68 206412 361828 90060139
Arthropathy 587.42 9.97 72 206408 366170 90055797
Renal impairment 538.10 9.97 906 205574 104515 90317452
Infusion related reaction 537.42 9.97 143 206337 416637 90005330
Cardiac failure congestive 515.47 9.97 857 205623 97837 90324130
Pulmonary hypertension 507.64 9.97 553 205927 41970 90379997
Joint swelling 488.07 9.97 270 206210 503030 89918937
Hepatic encephalopathy 485.17 9.97 333 206147 13439 90408528
Ascites 480.14 9.97 568 205912 47172 90374795
Dyspnoea 470.72 9.97 3521 202959 877434 89544533
Duodenal ulcer perforation 459.53 9.97 9 206471 221279 90200688
Helicobacter infection 456.58 9.97 13 206467 226837 90195130
Dehydration 456.29 9.97 1216 205264 193231 90228736
Wound 449.73 9.97 75 206405 302905 90119062
Renal failure 437.84 9.97 940 205540 130067 90291900
Bradycardia 432.35 9.97 724 205756 83123 90338844
Drug intolerance 419.73 9.97 250 206230 447341 89974626
Folliculitis 417.68 9.97 10 206470 204343 90217624
Maternal exposure during pregnancy 413.17 9.97 152 206328 359911 90062056
Drug ineffective 412.21 9.97 1694 204786 1382604 89039363
Therapeutic product effect decreased 404.71 9.97 72 206408 277499 90144468
Atrial fibrillation 403.96 9.97 921 205559 132690 90289277
Pericarditis 400.63 9.97 67 206413 270084 90151883
Hepatic enzyme increased 388.19 9.97 168 206312 360568 90061399
Muscle injury 385.16 9.97 3 206477 176651 90245316
Contraindicated product administered 369.20 9.97 134 206346 320005 90101962
Rheumatoid arthritis 352.03 9.97 194 206286 362420 90059547
Treatment failure 342.43 9.97 132 206348 303796 90118171
Hypersensitivity 342.42 9.97 319 206161 454358 89967609
Alopecia 335.86 9.97 380 206100 494691 89927276
Blood creatinine increased 333.55 9.97 723 205757 100663 90321304
Psoriatic arthropathy 324.73 9.97 63 206417 228272 90193695
Discomfort 324.56 9.97 110 206370 274225 90147742
Irritable bowel syndrome 319.91 9.97 46 206434 207402 90214565
Impaired healing 317.88 9.97 72 206408 234127 90187840
International normalised ratio increased 312.63 9.97 458 206022 46858 90375109
Oedema peripheral 302.98 9.97 1277 205203 256638 90165329
Hypervolaemia 300.40 9.97 372 206108 32385 90389582
Lower respiratory tract infection 283.74 9.97 108 206372 250551 90171416
Musculoskeletal stiffness 282.90 9.97 162 206318 296370 90125597
Blood potassium increased 279.84 9.97 288 206192 20461 90401506
Abdominal discomfort 275.75 9.97 413 206067 476915 89945052
Type 2 diabetes mellitus 263.07 9.97 69 206411 203175 90218792
Pain 261.95 9.97 1275 205205 995066 89426901
Ill-defined disorder 254.59 9.97 55 206425 184836 90237131
Cardiac failure chronic 253.72 9.97 159 206321 5487 90416480
Stomatitis 252.27 9.97 157 206323 274541 90147426
Anaemia 250.27 9.97 1515 204965 351287 90070680
Fluid retention 241.89 9.97 585 205895 87506 90334461
Blood cholesterol increased 241.51 9.97 86 206394 207926 90214041
Joint range of motion decreased 240.07 9.97 18 206462 135625 90286342
Blood urea increased 232.95 9.97 316 206164 30097 90391870
Swelling 227.32 9.97 378 206102 418680 90003287
Exposure during pregnancy 224.85 9.97 132 206348 238278 90183689
Liver injury 224.39 9.97 56 206424 170511 90251456
Bursitis 223.30 9.97 21 206459 131633 90290334
Dyspnoea exertional 215.79 9.97 496 205984 71792 90350175
Sensitisation 214.28 9.97 128 206352 4047 90417920
Syncope 212.88 9.97 726 205754 131937 90290030
Polycystic ovaries 206.94 9.97 140 206340 5514 90416453
Mobility decreased 206.77 9.97 161 206319 250573 90171394
Lip dry 202.25 9.97 6 206474 100949 90321018
Melaena 201.76 9.97 317 206163 34480 90387487
Gastrointestinal haemorrhage 198.04 9.97 551 205929 89697 90332270
Injury 195.13 9.97 103 206377 197246 90224721
Hypokalaemia 190.96 9.97 695 205785 130421 90291546
Renal disorder 188.54 9.97 322 206158 37537 90384430
Blister 186.95 9.97 183 206297 254815 90167152
Drug hypersensitivity 185.33 9.97 497 205983 463112 89958855
Sleep disorder due to general medical condition, insomnia type 181.86 9.97 36 206444 128658 90293309
Ejection fraction 177.51 9.97 101 206379 2910 90419057
Product use issue 174.77 9.97 302 206178 329617 90092350
Rash 172.04 9.97 1086 205394 795014 89626953
Grip strength decreased 170.53 9.97 10 206470 92566 90329401
Product prescribing error 169.77 9.97 271 206209 29874 90392093
Fall 167.28 9.97 1755 204725 480055 89941912
Blood pressure decreased 163.07 9.97 456 206024 74439 90347528
Cardiac disorder 162.91 9.97 384 206096 56488 90365479
Arthralgia 162.61 9.97 1073 205407 777449 89644518
Osteoarthritis 162.20 9.97 125 206355 195605 90226362
Urticaria 157.79 9.97 295 206185 312439 90109528
Hypercholesterolaemia 151.74 9.97 24 206456 100868 90321099
Nasopharyngitis 148.29 9.97 456 206024 406648 90015319
Sinusitis 146.90 9.97 355 206125 342733 90079234
Hepatic failure 146.52 9.97 297 206183 39431 90382536
Orthopnoea 142.69 9.97 121 206359 6714 90415253
Hypoaesthesia 142.67 9.97 315 206165 313895 90108072
N-terminal prohormone brain natriuretic peptide increased 142.19 9.97 87 206393 2875 90419092
Wound infection 141.74 9.97 34 206446 106368 90315599
Live birth 141.38 9.97 10 206470 79097 90342870
Sleep disorder 140.68 9.97 146 206334 197884 90224083
Chronic kidney disease 140.62 9.97 336 206144 49855 90372112
Gait inability 139.58 9.97 80 206400 146376 90275591
Cardiac failure acute 138.61 9.97 153 206327 11776 90410191
Night sweats 138.28 9.97 60 206420 128706 90293261
Glomerular filtration rate decreased 134.34 9.97 179 206301 16753 90405214
BRASH syndrome 132.70 9.97 71 206409 1808 90420159
Ventricular tachycardia 132.16 9.97 217 206263 24491 90397476
Gastrointestinal disorder 130.46 9.97 241 206239 256446 90165521
Pulmonary oedema 130.27 9.97 373 206107 61707 90360260
Pain in jaw 129.90 9.97 317 206163 47668 90374299
Brain natriuretic peptide increased 124.73 9.97 106 206374 5899 90416068
Ejection fraction abnormal 124.29 9.97 75 206405 2416 90419551
Off label use 124.16 9.97 1768 204712 1100484 89321483
Lactic acidosis 123.67 9.97 321 206159 50142 90371825
Infection 122.51 9.97 419 206061 361675 90060292
Cardioactive drug level increased 122.11 9.97 73 206407 2311 90419656
Fibromyalgia 119.34 9.97 178 206302 206091 90215876
Pleural effusion 117.95 9.97 537 205943 111454 90310513
Hip arthroplasty 114.89 9.97 18 206462 76190 90345777
Atrioventricular block 114.62 9.97 120 206360 8695 90413272
Sleep apnoea syndrome 111.96 9.97 233 206247 31514 90390453
Red blood cell sedimentation rate increased 110.78 9.97 26 206454 82569 90339398
Intentional product use issue 110.76 9.97 203 206277 216689 90205278
Atrial flutter 109.77 9.97 129 206351 10629 90411338
Sciatica 109.23 9.97 47 206433 101335 90320632
Congestive cardiomyopathy 104.48 9.97 105 206375 7249 90414718
Epistaxis 104.07 9.97 427 206053 84698 90337269
Labelled drug-drug interaction medication error 103.39 9.97 146 206334 14436 90407531
Respiratory failure 102.61 9.97 537 205943 117881 90304086
Haematoma 102.56 9.97 255 206225 38793 90383174
Blepharospasm 102.07 9.97 6 206474 55439 90366528
Blood bilirubin increased 101.91 9.97 272 206208 43198 90378769
Arrhythmia 101.39 9.97 267 206213 42065 90379902
Cardiogenic shock 101.24 9.97 192 206288 24276 90397691
Cardiomegaly 100.93 9.97 166 206314 18759 90403208
Transfusion 100.93 9.97 159 206321 17329 90404638
Pulmonary fibrosis 100.61 9.97 60 206420 107443 90314524
Product monitoring error 100.14 9.97 83 206397 4461 90417506
Bone erosion 99.91 9.97 5 206475 53016 90368951
Paraesthesia 97.89 9.97 271 206209 250055 90171912
Atrioventricular block complete 97.39 9.97 116 206364 9695 90412272
Palpitations 96.61 9.97 587 205893 136141 90285826
Hypothyroidism 96.16 9.97 303 206177 52824 90369143
Hepatocellular carcinoma 95.80 9.97 63 206417 2365 90419602
Haematemesis 95.79 9.97 227 206253 33499 90388468
Peripheral venous disease 95.14 9.97 36 206444 83885 90338082
Rhinitis allergic 94.65 9.97 151 206329 16634 90405333
Autoimmune disorder 93.80 9.97 29 206451 76715 90345252
Ischaemic stroke 93.03 9.97 175 206305 21991 90399976
Knee arthroplasty 92.13 9.97 37 206443 83145 90338822
Blood sodium decreased 91.97 9.97 198 206282 27415 90394552
Blood test abnormal 91.16 9.97 168 206312 20784 90401183
Prescribed overdose 90.64 9.97 55 206425 97570 90324397
X-ray abnormal 89.89 9.97 3 206477 45421 90376546
Arthritis 87.74 9.97 154 206326 167161 90254806
Lower limb fracture 87.54 9.97 42 206438 84971 90336996
Drug abuse 87.40 9.97 39 206441 82308 90339659
Inflammation 86.06 9.97 173 206307 178419 90243548
Hepatic function abnormal 85.62 9.97 266 206214 46022 90375945
Sputum culture positive 85.36 9.97 57 206423 2196 90419771
Oxygen saturation decreased 84.06 9.97 474 206006 107009 90314958
Vital capacity decreased 83.69 9.97 52 206428 1767 90420200
Pulmonary arterial pressure increased 83.13 9.97 70 206410 3846 90418121
Dry mouth 82.27 9.97 186 206294 183873 90238094
Sinus node dysfunction 81.94 9.97 80 206400 5332 90416635
Pericardial effusion 81.87 9.97 226 206254 36607 90385360
Hypovolaemia 81.61 9.97 120 206360 12311 90409656
Tricuspid valve incompetence 80.28 9.97 140 206340 16591 90405376
C-reactive protein increased 78.90 9.97 186 206294 181203 90240764
Atrial tachycardia 78.70 9.97 82 206398 5908 90416059
Left ventricular failure 77.95 9.97 86 206394 6614 90415353
Reversible airways obstruction 77.14 9.97 51 206429 1932 90420035
Nail disorder 76.48 9.97 20 206460 59047 90362920
Onychomadesis 76.24 9.97 8 206472 45990 90375977
Cardiomyopathy 75.62 9.97 152 206328 20054 90401913
Electrolyte imbalance 75.37 9.97 167 206313 23578 90398389
Varices oesophageal 75.01 9.97 65 206415 3714 90418253
Body tinea 73.44 9.97 51 206429 2097 90419870
Febrile neutropenia 73.25 9.97 157 206323 158192 90263775
Generalised oedema 72.11 9.97 144 206336 18909 90403058
Completed suicide 72.06 9.97 138 206342 144920 90277047
Obesity 71.33 9.97 81 206399 105426 90316541
Carpal tunnel syndrome 71.17 9.97 164 206316 23764 90398203
Concomitant disease aggravated 71.06 9.97 108 206372 11410 90410557
Prothrombin time prolonged 69.52 9.97 98 206382 9674 90412293
Device related infection 69.41 9.97 170 206310 25616 90396351
Road traffic accident 69.16 9.97 86 206394 107540 90314427
Acute respiratory failure 68.89 9.97 235 206245 42683 90379284
Injection site reaction 68.68 9.97 65 206415 92015 90329952
Catheter site infection 68.26 9.97 74 206406 5580 90416387
Catheter management 68.04 9.97 56 206424 2980 90418987
Upper gastrointestinal haemorrhage 67.82 9.97 157 206323 22819 90399148
Pulmonary congestion 67.79 9.97 142 206338 19291 90402676
Nephrectomy 67.64 9.97 47 206433 1934 90420033
Haemoglobin decreased 67.29 9.97 613 205867 161343 90260624
Orthostatic hypotension 67.11 9.97 229 206251 41598 90380369
Wheezing 66.68 9.97 297 206183 237783 90184184
Mitral valve incompetence 66.58 9.97 154 206326 22370 90399597
Pregnancy 66.46 9.97 29 206451 62018 90359949
Product use in unapproved indication 65.69 9.97 472 206008 335764 90086203
Hypoxia 65.25 9.97 332 206148 72067 90349900
Inappropriate antidiuretic hormone secretion 65.12 9.97 140 206340 19365 90402602
Adverse drug reaction 64.32 9.97 104 206376 116597 90305370
Congestive hepatopathy 63.94 9.97 54 206426 2979 90418988
Exostosis 63.29 9.97 21 206459 53113 90368854
Cellulitis 63.16 9.97 390 206090 90947 90331020
Joint stiffness 63.15 9.97 51 206429 77991 90343976
Paracentesis 63.06 9.97 35 206445 960 90421007
Epilepsy 62.52 9.97 57 206423 82149 90339818
Inhibitory drug interaction 61.97 9.97 54 206426 3109 90418858
Product quality issue 61.53 9.97 54 206426 79271 90342696
Haemoptysis 61.18 9.97 191 206289 33129 90388838
Metabolic acidosis 60.87 9.97 270 206210 55406 90366561
Shock haemorrhagic 60.76 9.97 104 206376 12141 90409826
Blood potassium decreased 60.38 9.97 242 206238 47485 90374482
Rhabdomyolysis 60.20 9.97 254 206226 51002 90370965
Multiple organ dysfunction syndrome 59.25 9.97 310 206170 68026 90353941
Ejection fraction decreased 58.26 9.97 161 206319 26092 90395875
Ammonia increased 58.01 9.97 64 206416 4922 90417045
Hidradenitis 58.00 9.97 60 206420 4287 90417680
Coeliac disease 57.95 9.97 15 206465 44595 90377372
Musculoskeletal pain 57.27 9.97 199 206281 171052 90250915
Oesophageal varices haemorrhage 57.14 9.97 38 206442 1454 90420513
Cor pulmonale 56.94 9.97 43 206437 2017 90419950
Foot deformity 56.22 9.97 33 206447 59618 90362349
Cough 56.06 9.97 1165 205315 367797 90054170
Onychomycosis 55.94 9.97 9 206471 37367 90384600
Colitis ulcerative 55.87 9.97 34 206446 60232 90361735
Dyspepsia 55.00 9.97 248 206232 197912 90224055
Prescribed underdose 54.73 9.97 54 206426 74965 90347002
Back injury 54.54 9.97 19 206461 46603 90375364
Portal hypertension 54.10 9.97 60 206420 4641 90417326
Abdominal distension 54.08 9.97 494 205986 130107 90291860
Taste disorder 53.95 9.97 37 206443 61509 90360458
Anuria 53.71 9.97 110 206370 14708 90407259
Cardiac arrest 53.58 9.97 416 206064 104519 90317448
Hypoglycaemia 53.26 9.97 306 206174 69542 90352425
Dizziness 53.10 9.97 1736 204744 587548 89834419
Shock 52.87 9.97 165 206315 28613 90393354
Polyuria 52.11 9.97 87 206393 9953 90412014
Sinoatrial block 52.06 9.97 31 206449 974 90420993
Bronchial secretion retention 52.06 9.97 52 206428 3563 90418404
Aspartate aminotransferase increased 51.96 9.97 407 206073 102530 90319437
Blood alkaline phosphatase increased 50.19 9.97 230 206250 47849 90374118
Gamma-glutamyltransferase increased 50.08 9.97 195 206285 37757 90384210
Oliguria 49.80 9.97 88 206392 10536 90411431
Pemphigoid 49.25 9.97 80 206400 8946 90413021
Myocardial infarction 49.15 9.97 411 206069 105561 90316406
Therapeutic drug monitoring analysis not performed 48.86 9.97 33 206447 1296 90420671
Hypovolaemic shock 48.78 9.97 70 206410 7024 90414943
Hepatorenal syndrome 48.48 9.97 39 206441 2009 90419958
Blood cholesterol decreased 48.33 9.97 38 206442 1893 90420074
Platelet count decreased 48.33 9.97 501 205979 136468 90285499
Subdural haematoma 48.31 9.97 113 206367 16532 90405435
Lupus-like syndrome 47.50 9.97 26 206454 48820 90373147
Death 47.22 9.97 1368 205112 455183 89966784
Migraine 47.20 9.97 248 206232 190144 90231823
Electrocardiogram QRS complex prolonged 46.89 9.97 70 206410 7278 90414689
Hepatic cirrhosis 46.86 9.97 275 206205 62978 90358989
Infection susceptibility increased 46.73 9.97 51 206429 3875 90418092
Poor quality sleep 46.68 9.97 143 206337 24550 90397417
Urinary retention 46.64 9.97 190 206290 37554 90384413
Lung disorder 46.28 9.97 180 206300 149703 90272264
Urine output decreased 46.20 9.97 94 206386 12509 90409458
Intentional overdose 45.96 9.97 90 206390 93744 90328223
Muscle spasticity 45.65 9.97 12 206468 35310 90386657
Drug tolerance decreased 45.35 9.97 9 206471 32121 90389846
Prerenal failure 45.30 9.97 38 206442 2077 90419890
Liver function test increased 44.56 9.97 78 206402 84777 90337190
Multiple allergies 44.16 9.97 103 206377 15043 90406924
Ventricular fibrillation 43.70 9.97 98 206382 13946 90408021
Jaundice 43.66 9.97 168 206312 32349 90389618
Concomitant disease progression 43.52 9.97 38 206442 2194 90419773
Inability to afford medication 43.02 9.97 47 206433 3575 90418392
Sepsis 42.21 9.97 609 205871 179205 90242762
Myelosuppression 42.15 9.97 36 206444 53555 90368412
Metabolic alkalosis 42.06 9.97 46 206434 3503 90418464
Hypochloraemia 42.04 9.97 40 206440 2582 90419385
Full blood count abnormal 41.92 9.97 180 206300 36417 90385550
Macular degeneration 41.86 9.97 17 206463 37953 90384014
Atrioventricular block first degree 41.85 9.97 72 206408 8439 90413528
Tachypnoea 41.78 9.97 125 206355 21184 90400783
Lichen planopilaris 41.39 9.97 16 206464 184 90421783
Hypertrichosis 41.17 9.97 31 206449 1448 90420519
Peripheral circulatory failure 41.09 9.97 32 206448 1572 90420395
Incorrect route of product administration 41.06 9.97 33 206447 50593 90371374
Sudden death 40.75 9.97 82 206398 10827 90411140
Walking aid user 40.63 9.97 15 206465 35491 90386476
Lung transplant 40.57 9.97 46 206434 3646 90418321
Bundle branch block left 40.49 9.97 68 206412 7817 90414150
Catheterisation cardiac 40.25 9.97 53 206427 4903 90417064
Hyperglycaemia 39.98 9.97 225 206255 50745 90371222
Hospitalisation 39.85 9.97 457 206023 127643 90294324
Left ventricular dysfunction 39.79 9.97 97 206383 14572 90407395
Sinus bradycardia 39.65 9.97 106 206374 16846 90405121
Catheter placement 39.51 9.97 38 206442 2486 90419481
Acute pulmonary oedema 39.41 9.97 75 206405 9505 90412462
Haemorrhagic disorder 39.30 9.97 26 206454 986 90420981
Eosinophil count increased 39.28 9.97 90 206390 12991 90408976
Bundle branch block right 39.25 9.97 55 206425 5398 90416569
Catheter site erythema 39.22 9.97 52 206428 4842 90417125
Haemoglobin increased 39.06 9.97 65 206415 7416 90414551
Hypertension 38.45 9.97 773 205707 456759 89965208
Hyperthyroidism 38.38 9.97 110 206370 18200 90403767
Purpura 38.27 9.97 96 206384 14682 90407285
Foreign body in reproductive tract 38.04 9.97 27 206453 1150 90420817
Dementia 37.72 9.97 130 206350 23731 90398236
Jugular vein distension 37.48 9.97 26 206454 1067 90420900
Iron deficiency anaemia 37.48 9.97 129 206351 23533 90398434
Foetal exposure during pregnancy 37.45 9.97 26 206454 42949 90379018
Blood aldosterone increased 37.23 9.97 15 206465 194 90421773
Dyspnoea at rest 37.01 9.97 50 206430 4741 90417226
Adverse event 36.90 9.97 140 206340 117278 90304689
Peripartum cardiomyopathy 36.62 9.97 15 206465 203 90421764
Gastric polyps 36.46 9.97 49 206431 4623 90417344
Disability 36.38 9.97 24 206456 40721 90381246
Anaphylactic reaction 36.27 9.97 92 206388 87432 90334535
Joint dislocation 36.23 9.97 29 206451 44553 90377414
Gout 36.04 9.97 102 206378 16757 90405210
Abortion spontaneous 35.99 9.97 42 206438 54014 90367953
Waist circumference increased 35.75 9.97 24 206456 933 90421034
Blood creatine increased 35.66 9.97 60 206420 6907 90415060
Oxygen consumption increased 35.62 9.97 48 206432 4541 90417426
Catheter site discharge 35.34 9.97 35 206445 2374 90419593
Pyrexia 34.80 9.97 1194 205286 659291 89762676
Neuroglycopenia 34.71 9.97 25 206455 1090 90420877
Psoriasis 34.67 9.97 196 206284 147558 90274409
Altered state of consciousness 34.52 9.97 153 206327 31379 90390588
Contusion 34.38 9.97 386 206094 250830 90171137
Cardioversion 34.38 9.97 27 206453 1343 90420624
Cardiac output decreased 34.36 9.97 24 206456 996 90420971
Cyanosis 34.32 9.97 110 206370 19345 90402622
Abdominal cavity drainage 34.23 9.97 18 206462 442 90421525
Chest pain 34.17 9.97 962 205518 318683 90103284
Ear infection 34.10 9.97 67 206413 69708 90352259
Immunodeficiency 34.05 9.97 29 206451 43205 90378762
Nephropathy 34.00 9.97 69 206411 9166 90412801
Peripheral swelling 33.79 9.97 701 205779 412405 90009562
Heart valve incompetence 33.78 9.97 40 206440 3322 90418645
Respiratory distress 33.29 9.97 176 206304 38770 90383197
Pulmonary arterial wedge pressure increased 33.26 9.97 17 206463 393 90421574
Therapeutic product effect incomplete 33.24 9.97 282 206198 193614 90228353
Laryngitis 33.18 9.97 40 206440 50713 90371254
Electrocardiogram QT prolonged 33.05 9.97 280 206200 72176 90349791
Ischaemic cardiomyopathy 32.96 9.97 35 206445 2578 90419389
Parkinsonism 32.95 9.97 88 206392 13977 90407990
Acute myocardial infarction 32.84 9.97 162 206318 34728 90387239
Cardiorenal syndrome 32.50 9.97 24 206456 1088 90420879
Cerebral infarction 32.17 9.97 133 206347 26463 90395504
Hepatomegaly 31.85 9.97 84 206396 13242 90408725
Cirrhosis alcoholic 31.68 9.97 15 206465 292 90421675
Atrial enlargement 31.49 9.97 16 206464 365 90421602
Chronic obstructive pulmonary disease 31.44 9.97 281 206199 73548 90348419
Ventricular hypokinesia 31.43 9.97 49 206431 5292 90416675
Right ventricular dilatation 31.28 9.97 28 206452 1671 90420296
Acidosis 31.18 9.97 81 206399 12655 90409312
Glucose tolerance impaired 31.00 9.97 61 206419 7924 90414043
Hyperuricaemia 30.66 9.97 55 206425 6664 90415303
Renin increased 30.59 9.97 13 206467 194 90421773
Haemorrhage 30.56 9.97 266 206214 69103 90352864
Intra-abdominal fluid collection 30.52 9.97 35 206445 2809 90419158
Aortic stenosis 30.37 9.97 53 206427 6283 90415684
Vascular resistance pulmonary decreased 30.23 9.97 10 206470 70 90421897
Frequent bowel movements 30.20 9.97 52 206428 56883 90365084
Adverse reaction 30.10 9.97 15 206465 29697 90392270
Diffuse large B-cell lymphoma refractory 29.89 9.97 28 206452 1772 90420195
Pulmonary arterial pressure abnormal 29.49 9.97 18 206462 592 90421375
Portal vein thrombosis 29.35 9.97 36 206444 3102 90418865
Bradyarrhythmia 29.34 9.97 32 206448 2429 90419538
Blood pressure abnormal 29.30 9.97 105 206375 19540 90402427
Diarrhoea 29.23 9.97 2501 203979 936689 89485278
Liver transplant 29.16 9.97 31 206449 2286 90419681
Portopulmonary hypertension 29.14 9.97 11 206469 118 90421849
Dizziness postural 29.10 9.97 64 206416 8989 90412978
Upper-airway cough syndrome 28.94 9.97 88 206392 15047 90406920
Foetal death 28.84 9.97 6 206474 20717 90401250
Thermohypoaesthesia 28.81 9.97 11 206469 122 90421845
Dyspnoea paroxysmal nocturnal 28.66 9.97 22 206458 1058 90420909
Therapy non-responder 28.59 9.97 188 206292 136516 90285451
Blood loss anaemia 28.52 9.97 68 206412 10072 90411895
Oedema 28.30 9.97 626 205854 199669 90222298
Vascular access site thrombosis 28.25 9.97 9 206471 55 90421912
Cardiospasm 28.21 9.97 37 206443 3409 90418558
Therapeutic response decreased 28.18 9.97 107 206373 89622 90332345
Pulmonary hypertensive crisis 28.12 9.97 16 206464 461 90421506
Occult blood positive 28.11 9.97 40 206440 3983 90417984
Poor peripheral circulation 28.09 9.97 40 206440 3985 90417982
Cardio-respiratory arrest 27.75 9.97 242 206238 62898 90359069
Bradykinesia 27.75 9.97 53 206427 6735 90415232
Device stimulation issue 27.71 9.97 9 206471 59 90421908
Toxicity to various agents 27.67 9.97 475 206005 287371 90134596
Ischaemic contracture of the left ventricle 27.67 9.97 11 206469 137 90421830
Hepatic cancer 27.64 9.97 44 206436 4837 90417130
N-terminal prohormone brain natriuretic peptide abnormal 27.58 9.97 9 206471 60 90421907
Aortic valve incompetence 27.43 9.97 52 206428 6572 90415395
Presyncope 27.37 9.97 144 206336 31661 90390306
Food allergy 27.14 9.97 12 206468 25466 90396501
Sight disability 27.11 9.97 11 206469 145 90421822
Haemorrhage subcutaneous 27.09 9.97 36 206444 3360 90418607
Device alarm issue 26.94 9.97 27 206453 1858 90420109
Hypertrophic cardiomyopathy 26.62 9.97 29 206451 2199 90419768
Bilirubin conjugated increased 26.24 9.97 34 206446 3096 90418871
Palmoplantar keratoderma 26.18 9.97 36 206444 3471 90418496
Bile acid malabsorption 26.18 9.97 13 206467 282 90421685
Product administration interrupted 26.14 9.97 75 206405 12417 90409550
Haemorrhoidal haemorrhage 26.13 9.97 45 206435 5278 90416689
Loss of consciousness 26.12 9.97 457 206023 139781 90282186
Circulatory collapse 25.89 9.97 119 206361 24785 90397182
Monocytosis 25.83 9.97 20 206460 974 90420993
Chronic hepatic failure 25.76 9.97 17 206463 642 90421325
Pruritus genital 25.69 9.97 41 206439 4517 90417450
Hyperbilirubinaemia 25.69 9.97 80 206400 13856 90408111
Drug-induced liver injury 25.67 9.97 112 206368 90206 90331761
Alanine aminotransferase increased 25.50 9.97 395 206085 117943 90304024
Device related sepsis 25.50 9.97 42 206438 4751 90417216
Diabetes mellitus inadequate control 25.47 9.97 97 206383 18587 90403380
Renal artery stenosis 25.42 9.97 28 206452 2149 90419818
Vascular device infection 25.24 9.97 72 206408 11880 90410087
Right ventricular dysfunction 25.21 9.97 29 206451 2335 90419632
Torsade de pointes 25.13 9.97 84 206396 15098 90406869
Memory impairment 25.08 9.97 308 206172 196936 90225031
Vascular access site infection 25.05 9.97 9 206471 83 90421884
Flushing 25.01 9.97 310 206170 88181 90333786
Embolic stroke 24.86 9.97 38 206442 4034 90417933
Activated partial thromboplastin time prolonged 24.79 9.97 55 206425 7770 90414197
Electrocardiogram abnormal 24.70 9.97 65 206415 10233 90411734
Sputum culture 24.66 9.97 13 206467 321 90421646
Cortisol increased 24.64 9.97 15 206465 491 90421476
Calcium deficiency 24.60 9.97 22 206458 1311 90420656
Marasmus 24.59 9.97 18 206462 805 90421162
Peritonitis bacterial 24.46 9.97 43 206437 5128 90416839
Blood pressure systolic abnormal 24.45 9.97 7 206473 19471 90402496
Transplant evaluation 24.42 9.97 22 206458 1324 90420643
Proctitis 24.42 9.97 3 206477 15256 90406711
Systemic infection 24.28 9.97 41 206439 4734 90417233
Fear of eating 24.15 9.97 14 206466 418 90421549
Cardiac dysfunction 24.01 9.97 35 206445 3562 90418405
Coagulopathy 24.00 9.97 111 206369 23178 90398789
Stupor 23.90 9.97 44 206436 5438 90416529
Spur cell anaemia 23.83 9.97 8 206472 59 90421908
Drug dispensed to wrong patient 23.78 9.97 13 206467 346 90421621
Multimorbidity 23.74 9.97 16 206464 626 90421341
Erysipelas 23.64 9.97 59 206421 8993 90412974
Ear pain 23.64 9.97 61 206419 57641 90364326
Right atrial dilatation 23.58 9.97 17 206463 742 90421225
Catheter site pain 23.35 9.97 44 206436 5535 90416432
Renin decreased 23.32 9.97 9 206471 103 90421864
Drug resistance 23.28 9.97 21 206459 30428 90391539
Burning sensation 23.28 9.97 234 206246 63218 90358749
Ventricular arrhythmia 23.17 9.97 38 206442 4283 90417684
Multiple drug therapy 23.04 9.97 50 206430 6959 90415008
Cardiac hypertrophy 22.85 9.97 20 206460 1158 90420809
Splenomegaly 22.73 9.97 73 206407 12851 90409116
Blood albumin decreased 22.71 9.97 87 206393 16716 90405251
Neck pain 22.69 9.97 159 206321 113804 90308163
Cardiopulmonary failure 22.69 9.97 37 206443 4151 90417816
Catheter removal 22.65 9.97 13 206467 381 90421586
Puncture site haemorrhage 22.52 9.97 13 206467 385 90421582
Walking distance test abnormal 22.46 9.97 15 206465 578 90421389
Multiple sclerosis relapse 22.43 9.97 54 206426 52251 90369716
Injection site erythema 22.39 9.97 132 206348 98370 90323597
Neonatal respiratory failure 22.34 9.97 12 206468 308 90421659
Sinus arrest 22.34 9.97 26 206454 2120 90419847
Sleep terror 22.26 9.97 38 206442 4426 90417541
Vessel puncture site haemorrhage 22.23 9.97 9 206471 118 90421849
Dry skin 22.15 9.97 302 206178 87771 90334196
Vasodilatation 22.13 9.97 30 206450 2854 90419113
Pulmonary veno-occlusive disease 21.92 9.97 22 206458 1516 90420451
Blood glucose increased 21.71 9.97 321 206159 94925 90327042
Asthenia 21.67 9.97 1452 205028 532299 89889668
Brain natriuretic peptide abnormal 21.65 9.97 13 206467 415 90421552
Exercise tolerance decreased 21.63 9.97 51 206429 7500 90414467
Supraventricular tachycardia 21.60 9.97 84 206396 16252 90405715
Aortic valve calcification 21.55 9.97 15 206465 619 90421348
Feeling abnormal 21.55 9.97 516 205964 166719 90255248
Low cardiac output syndrome 21.51 9.97 13 206467 420 90421547
Urinary tract infection 21.49 9.97 876 205604 304756 90117211
Hypernatraemia 21.26 9.97 58 206422 9329 90412638
Muscular weakness 21.18 9.97 337 206143 206329 90215638
Hepatitis 21.16 9.97 86 206394 70653 90351314
Nodal arrhythmia 21.12 9.97 20 206460 1283 90420684
Disseminated intravascular coagulation 20.99 9.97 101 206379 21437 90400530
Azotaemia 20.94 9.97 41 206439 5307 90416660
Left-to-right cardiac shunt 20.89 9.97 11 206469 271 90421696
Amnesia 20.82 9.97 153 206327 108352 90313615
Temperature regulation disorder 20.75 9.97 4 206476 14575 90407392
Aspiration pleural cavity 20.75 9.97 17 206463 899 90421068
Red cell distribution width abnormal 20.74 9.97 10 206470 203 90421764
Tenosynovitis 20.73 9.97 4 206476 14563 90407404
Blood pressure systolic decreased 20.72 9.97 57 206423 9213 90412754
Electrocardiogram change 20.69 9.97 16 206464 778 90421189
Dermatitis contact 20.56 9.97 73 206407 13522 90408445
Viral diarrhoea 20.52 9.97 10 206470 208 90421759
Hypoalbuminaemia 20.42 9.97 81 206399 15816 90406151
Intentional self-injury 20.39 9.97 22 206458 29312 90392655
Hypophagia 20.33 9.97 146 206334 35791 90386176
Inferior vena cava dilatation 20.32 9.97 8 206472 97 90421870
Injection site pain 20.32 9.97 276 206204 173423 90248544
Hyperglycaemic hyperosmolar nonketotic syndrome 20.28 9.97 20 206460 1349 90420618
Lower gastrointestinal haemorrhage 20.19 9.97 55 206425 8837 90413130
Catheter site inflammation 20.09 9.97 17 206463 940 90421027
Pulmonary vascular resistance abnormality 19.96 9.97 8 206472 102 90421865
Venous pressure jugular increased 19.94 9.97 14 206466 586 90421381
Joint effusion 19.89 9.97 10 206470 19700 90402267
Electrocardiogram T wave amplitude increased 19.84 9.97 6 206474 30 90421937
Drug tolerance 19.78 9.97 8 206472 17908 90404059
Septic shock 19.72 9.97 285 206195 83875 90338092
Duodenal ulcer 19.65 9.97 57 206423 9495 90412472
Hypotonia 19.61 9.97 64 206416 11362 90410605
Gastric varices haemorrhage 19.60 9.97 9 206471 163 90421804
Initial insomnia 19.58 9.97 56 206424 9254 90412713
International normalised ratio abnormal 19.53 9.97 33 206447 3812 90418155
Carotid artery occlusion 19.45 9.97 44 206436 6298 90415669
Schizophrenia 19.40 9.97 5 206475 14909 90407058
Brain stem stroke 19.36 9.97 12 206468 406 90421561
Toxic skin eruption 19.17 9.97 79 206401 15695 90406272
Metastases to central nervous system 19.10 9.97 8 206472 17534 90404433
Senile dementia 19.08 9.97 10 206470 244 90421723
Depression 19.06 9.97 530 205950 300071 90121896
Cardiovascular insufficiency 19.04 9.97 21 206459 1614 90420353
Localised oedema 19.02 9.97 43 206437 6151 90415816
Nasal congestion 18.96 9.97 281 206199 83133 90338834
Toxic epidermal necrolysis 18.90 9.97 133 206347 32395 90389572
Nodal rhythm 18.88 9.97 22 206458 1796 90420171
Encephalopathy 18.87 9.97 175 206305 46269 90375698
Therapeutic embolisation 18.82 9.97 10 206470 251 90421716
Catheter site swelling 18.81 9.97 22 206458 1803 90420164
Diet noncompliance 18.79 9.97 12 206468 428 90421539
Pulmonary aplasia 18.79 9.97 5 206475 14 90421953
Portal hypertensive gastropathy 18.77 9.97 17 206463 1030 90420937
Scleroderma 18.71 9.97 43 206437 6218 90415749
Subcutaneous drug absorption impaired 18.69 9.97 4 206476 13541 90408426
Anxiety 18.67 9.97 550 205930 309222 90112745
Dermatitis atopic 18.66 9.97 104 206376 23368 90398599
Decreased appetite 18.56 9.97 1042 205438 375498 90046469
Left ventricular enlargement 18.55 9.97 7 206473 75 90421892
Central venous catheterisation 18.44 9.97 27 206453 2759 90419208
Fatigue 18.43 9.97 2326 204154 1151697 89270270
Female sexual arousal disorder 18.39 9.97 6 206474 40 90421927
Blood potassium abnormal 18.36 9.97 28 206452 2966 90419001
Chest injury 18.36 9.97 23 206457 2025 90419942
Premature labour 18.35 9.97 4 206476 13372 90408595
Sudden cardiac death 18.33 9.97 24 206456 2208 90419759
Cardiac murmur 18.22 9.97 86 206394 18108 90403859
Cardiac failure high output 18.21 9.97 12 206468 452 90421515
Renal injury 18.14 9.97 58 206422 10185 90411782
Bleeding varicose vein 18.07 9.97 11 206469 360 90421607
Respiratory disorder 18.04 9.97 81 206399 64735 90357232
Psychotic disorder 17.99 9.97 27 206453 31203 90390764
Product odour abnormal 17.99 9.97 20 206460 1551 90420416
Hypercapnia 17.95 9.97 44 206436 6633 90415334
Pneumonia 17.93 9.97 1687 204793 636372 89785595
Haemodialysis 17.80 9.97 52 206428 8695 90413272
Left atrial dilatation 17.77 9.97 22 206458 1914 90420053
Catheter site pruritus 17.75 9.97 24 206456 2278 90419689
Hypophosphataemia 17.74 9.97 74 206406 14780 90407187
Gouty arthritis 17.73 9.97 13 206467 583 90421384
Neurological decompensation 17.72 9.97 30 206450 3471 90418496
Neutropenia 17.67 9.97 384 206096 224520 90197447
Ventricular failure 17.67 9.97 11 206469 375 90421592
Tension headache 17.61 9.97 47 206433 7462 90414505
Upper respiratory tract infection 17.61 9.97 197 206283 128121 90293846
Cardiac pacemaker insertion 17.51 9.97 34 206446 4373 90417594
Complication of device insertion 17.50 9.97 58 206422 10378 90411589
Asthma 17.47 9.97 419 206061 241741 90180226
Ventricular extrasystoles 17.41 9.97 68 206412 13182 90408785
Blood chloride decreased 17.37 9.97 42 206438 6277 90415690
Pain in extremity 17.35 9.97 844 205636 449685 89972282
Chronic respiratory failure 17.33 9.97 26 206454 2715 90419252
Eye inflammation 17.27 9.97 48 206432 7803 90414164
Rash vesicular 17.24 9.97 10 206470 18187 90403780
Leukaemic infiltration renal 17.24 9.97 5 206475 21 90421946
General symptom 17.12 9.97 6 206474 14662 90407305
Angina unstable 17.05 9.97 45 206435 7098 90414869
Sleep disorder due to a general medical condition 16.90 9.97 166 206314 44572 90377395
Blood bilirubin unconjugated increased 16.89 9.97 11 206469 406 90421561
Haemodynamic instability 16.88 9.97 62 206418 11677 90410290
Asterixis 16.85 9.97 20 206460 1665 90420302
Oligohydramnios 16.81 9.97 45 206435 7156 90414811
Cardiac ablation 16.67 9.97 20 206460 1684 90420283
Myocardial ischaemia 16.64 9.97 69 206411 13745 90408222
Faeces discoloured 16.64 9.97 94 206386 21226 90400741
Hypertonic bladder 16.62 9.97 33 206447 4315 90417652
Primary biliary cholangitis 16.62 9.97 18 206462 1356 90420611
Labelled drug-drug interaction issue 16.59 9.97 23 206457 2235 90419732
Hyperlipidaemia 16.56 9.97 99 206381 22817 90399150
Pustular psoriasis 16.47 9.97 11 206469 18545 90403422
Stevens-Johnson syndrome 16.42 9.97 119 206361 29257 90392710
Upper respiratory tract inflammation 16.40 9.97 25 206455 2647 90419320
Hypocalcaemia 16.39 9.97 158 206322 42210 90379757
Chronic sinusitis 16.38 9.97 18 206462 23784 90398183
Cytomegalovirus infection 16.32 9.97 22 206458 26580 90395387
Atrial septal defect repair 16.28 9.97 9 206471 245 90421722
Endocarditis 16.16 9.97 44 206436 7069 90414898
Renal tubular acidosis 16.15 9.97 23 206457 2292 90419675
Urine output increased 16.13 9.97 20 206460 1742 90420225
Tachycardia 16.13 9.97 472 206008 157201 90264766
Maternal exposure before pregnancy 16.12 9.97 3 206477 11210 90410757
Gastroenteritis 16.11 9.97 118 206362 29111 90392856
Intestinal haemorrhage 16.10 9.97 33 206447 4414 90417553
Pallor 16.10 9.97 133 206347 34032 90387935
Liver function test abnormal 16.08 9.97 182 206298 50663 90371304
Blood parathyroid hormone decreased 16.07 9.97 4 206476 12212 90409755
Blood pressure diastolic abnormal 16.07 9.97 13 206467 19868 90402099
Rales 15.99 9.97 75 206405 15752 90406215
Mixed hepatocellular cholangiocarcinoma 15.97 9.97 4 206476 8 90421959
Gastric antral vascular ectasia 15.93 9.97 14 206466 815 90421152
Cardiac cirrhosis 15.93 9.97 8 206472 178 90421789
Hepatorenal failure 15.92 9.97 13 206467 684 90421283
Amaurosis 15.92 9.97 14 206466 816 90421151
Malignant ascites 15.91 9.97 15 206465 957 90421010
Insomnia 15.89 9.97 610 205870 332864 90089103
Gastrointestinal arteriovenous malformation 15.89 9.97 12 206468 563 90421404
Flatulence 15.88 9.97 154 206326 41213 90380754
Blood uric acid increased 15.87 9.97 46 206434 7658 90414309
Puncture site haematoma 15.84 9.97 6 206474 65 90421902
Pericarditis constrictive 15.83 9.97 12 206468 566 90421401
Oesophageal variceal ligation 15.77 9.97 5 206475 30 90421937
Dilatation ventricular 15.69 9.97 23 206457 2353 90419614
Alcoholic liver disease 15.65 9.97 7 206473 119 90421848
Mitral valve disease 15.63 9.97 24 206456 2558 90419409
Right ventricular systolic pressure increased 15.52 9.97 12 206468 583 90421384
Catheter site haemorrhage 15.44 9.97 29 206451 3639 90418328
Postpericardiotomy syndrome 15.36 9.97 4 206476 10 90421957
Product administration error 15.33 9.97 108 206372 26315 90395652
Simple partial seizures 15.32 9.97 13 206467 722 90421245
Intestinal varices haemorrhage 15.26 9.97 3 206477 0 90421967
Bone density decreased 15.25 9.97 79 206401 17266 90404701
Catastrophic reaction 15.24 9.97 5 206475 34 90421933
Brain natriuretic peptide 15.24 9.97 5 206475 34 90421933
Gastric ulcer 15.23 9.97 111 206369 27337 90394630
Facial pain 15.22 9.97 65 206415 13117 90408850
Adrenal adenoma 15.21 9.97 16 206464 1166 90420801
Cardiac valve disease 15.16 9.97 33 206447 4602 90417365
Cardiac flutter 15.15 9.97 33 206447 4605 90417362
Angina pectoris 15.13 9.97 146 206334 39014 90382953
Suicide attempt 15.11 9.97 105 206375 75294 90346673
Panniculitis 15.10 9.97 7 206473 14451 90407516
Radiculopathy 15.08 9.97 12 206468 18493 90403474
Peripheral artery occlusion 15.07 9.97 18 206462 1508 90420459
Nephrogenic anaemia 15.04 9.97 23 206457 2443 90419524
Bronchopulmonary dysplasia 15.02 9.97 12 206468 612 90421355
No adverse event 14.97 9.97 92 206388 67890 90354077
Subchorionic haematoma 14.94 9.97 7 206473 133 90421834
Dystonia 14.89 9.97 10 206470 16809 90405158
Primary hyperaldosteronism 14.86 9.97 6 206474 78 90421889
Product used for unknown indication 14.84 9.97 13 206467 754 90421213
Agranulocytosis 14.78 9.97 133 206347 34869 90387098
International normalised ratio decreased 14.74 9.97 33 206447 4691 90417276
Euglycaemic diabetic ketoacidosis 14.73 9.97 39 206441 6162 90415805
Normal newborn 14.66 9.97 19 206461 23343 90398624
Volume blood decreased 14.60 9.97 8 206472 214 90421753
Gastritis erosive 14.57 9.97 41 206439 6714 90415253
Drug monitoring procedure not performed 14.55 9.97 13 206467 774 90421193
Chronic right ventricular failure 14.54 9.97 5 206475 40 90421927
Blood urea abnormal 14.50 9.97 14 206466 920 90421047
Diarrhoea infectious 14.48 9.97 16 206464 1233 90420734
Prothrombin time abnormal 14.47 9.97 11 206469 521 90421446
Product substitution issue 14.45 9.97 80 206400 17928 90404039
Sensory loss 14.39 9.97 12 206468 18063 90403904
Coma hepatic 14.33 9.97 12 206468 654 90421313
Traumatic haematoma 14.27 9.97 19 206461 1776 90420191
Haematocrit abnormal 14.27 9.97 15 206465 1092 90420875
Depressed level of consciousness 14.20 9.97 239 206241 72545 90349422
Toxic neuropathy 14.18 9.97 11 206469 537 90421430
Bronchiectasis 14.18 9.97 18 206462 22312 90399655
Unevaluable event 14.17 9.97 189 206291 54659 90367308
Deformity 14.16 9.97 5 206475 12165 90409802
Pancreatic enzymes decreased 14.15 9.97 4 206476 15 90421952
Hyperaldosteronism 14.09 9.97 9 206471 321 90421646
Infusion site pain 14.09 9.97 85 206395 19653 90402314
Ulcer 14.06 9.97 34 206446 32848 90389119
Akathisia 14.03 9.97 4 206476 11155 90410812
Emergency care examination 14.01 9.97 7 206473 154 90421813
Drug reaction with eosinophilia and systemic symptoms 13.95 9.97 154 206326 42604 90379363
Blood catecholamines decreased 13.95 9.97 4 206476 16 90421951
Staphylococcal sepsis 13.86 9.97 50 206430 9333 90412634
Hepatitis C 13.86 9.97 36 206444 5624 90416343
Pulmonary haemorrhage 13.86 9.97 45 206435 7968 90413999
Acute on chronic liver failure 13.85 9.97 9 206471 331 90421636
Drug therapeutic incompatibility 13.83 9.97 5 206475 47 90421920
Sedation complication 13.80 9.97 11 206469 16933 90405034
Neuromyelitis optica spectrum disorder 13.78 9.97 17 206463 1473 90420494
Walking disability 13.74 9.97 17 206463 1478 90420489
Strabismus 13.64 9.97 22 206458 2446 90419521
Polyarthritis 13.62 9.97 13 206467 18337 90403630
Neurodevelopmental disorder 13.62 9.97 8 206472 245 90421722
Catheter site abscess 13.56 9.97 8 206472 247 90421720
Glomerular filtration rate abnormal 13.51 9.97 16 206464 1329 90420638
Cerebral haemorrhage 13.49 9.97 129 206351 34393 90387574
Ectopic ACTH syndrome 13.35 9.97 7 206473 171 90421796
Coronary artery disease 13.31 9.97 126 206354 33497 90388470
Catheter site scab 13.30 9.97 8 206472 256 90421711
Hepatic hydrothorax 13.30 9.97 5 206475 53 90421914
Pain of skin 13.28 9.97 72 206408 16010 90405957
Urogenital haemorrhage 13.22 9.97 8 206472 259 90421708
Palliative care 13.21 9.97 13 206467 875 90421092
Platelet dysfunction 13.20 9.97 6 206474 106 90421861
Ulcer haemorrhage 13.10 9.97 25 206455 26296 90395671
Duodenal ulcer haemorrhage 13.07 9.97 22 206458 2534 90419433
Pulmonary arteriovenous fistula 13.06 9.97 4 206476 21 90421946
CREST syndrome 13.04 9.97 11 206469 606 90421361
Left ventricular hypertrophy 12.96 9.97 37 206443 6107 90415860
Progressive multifocal leukoencephalopathy 12.95 9.97 10 206470 15645 90406322
Lip erosion 12.89 9.97 15 206465 1223 90420744
Neuropathy peripheral 12.84 9.97 227 206253 136743 90285224
Dilatation atrial 12.82 9.97 19 206461 1962 90420005
Thromboembolectomy 12.82 9.97 5 206475 59 90421908
Hepatitis fulminant 12.81 9.97 28 206452 3917 90418050
Mucocutaneous haemorrhage 12.81 9.97 6 206474 114 90421853
Cardiac operation 12.79 9.97 28 206452 3921 90418046
Urine potassium increased 12.76 9.97 4 206476 23 90421944
Extensor plantar response 12.75 9.97 16 206464 1411 90420556
Neonatal hyponatraemia 12.75 9.97 5 206475 60 90421907
Blood antidiuretic hormone increased 12.73 9.97 3 206477 4 90421963
Dermoid cyst 12.72 9.97 10 206470 498 90421469
Subarachnoid haemorrhage 12.72 9.97 77 206403 17827 90404140
Cytokine release syndrome 12.71 9.97 28 206452 27945 90394022
Electrocardiogram QT shortened 12.68 9.97 7 206473 190 90421777
Immunisation 12.60 9.97 20 206460 2193 90419774
Anticoagulation drug level above therapeutic 12.53 9.97 19 206461 2003 90419964
Urine glucose/creatinine ratio increased 12.51 9.97 7 206473 195 90421772
Blood culture negative 12.51 9.97 7 206473 195 90421772
Foetal growth restriction 12.48 9.97 3 206477 9377 90412590
Ventricular assist device insertion 12.48 9.97 4 206476 25 90421942
Infusion site reaction 12.45 9.97 15 206465 19024 90402943
Malignant neoplasm progression 12.42 9.97 170 206310 106700 90315267
Head injury 12.41 9.97 117 206363 31071 90390896
Exposure to SARS-CoV-2 12.40 9.97 21 206459 2431 90419536
Haematoma muscle 12.35 9.97 18 206462 1832 90420135
Portal shunt 12.35 9.97 4 206476 26 90421941
Left ventricular dilatation 12.32 9.97 11 206469 654 90421313
Cardiac ventricular thrombosis 12.24 9.97 14 206466 1120 90420847
Right ventricular hypertrophy 12.23 9.97 12 206468 805 90421162
Incision site impaired healing 12.23 9.97 9 206471 406 90421561
Catheter site rash 12.19 9.97 12 206468 808 90421159
Nocturia 12.18 9.97 51 206429 10204 90411763
Renal function test abnormal 12.09 9.97 40 206440 7151 90414816
Cutaneous vasculitis 12.08 9.97 40 206440 7153 90414814
Gamma-glutamyltransferase abnormal 12.07 9.97 10 206470 537 90421430
Staphylococcus test positive 12.07 9.97 29 206451 4316 90417651
Listeraemia 12.05 9.97 5 206475 70 90421897
Treatment noncompliance 12.05 9.97 175 206305 51552 90370415
Hypomagnesaemia 11.99 9.97 129 206351 35459 90386508
Device connection issue 11.96 9.97 13 206467 983 90420984
Stress 11.95 9.97 123 206357 81272 90340695
Blood glucose abnormal 11.90 9.97 48 206432 9444 90412523
Productive cough 11.89 9.97 244 206236 76819 90345148
Abdominal pain upper 11.88 9.97 628 205852 332046 90089921
Pulseless electrical activity 11.87 9.97 46 206434 8886 90413081
Tachyarrhythmia 11.84 9.97 33 206447 5373 90416594
Ventricular dyssynchrony 11.80 9.97 5 206475 74 90421893
Electrocardiogram T wave inversion 11.80 9.97 26 206454 3657 90418310
Coordination abnormal 11.79 9.97 19 206461 21337 90400630
Nasal polyps 11.78 9.97 5 206475 10875 90411092
Injection site pruritus 11.78 9.97 73 206407 53761 90368206
Ulcerative keratitis 11.77 9.97 25 206455 3428 90418539
Heart sounds abnormal 11.77 9.97 11 206469 694 90421273
Periumbilical abscess 11.75 9.97 7 206473 220 90421747
Visual acuity reduced transiently 11.75 9.97 7 206473 220 90421747
Gastrointestinal angiectasia 11.74 9.97 5 206475 75 90421892
Anosmia 11.71 9.97 49 206431 9799 90412168
Haemorrhagic stroke 11.70 9.97 37 206443 6459 90415508
Wrong patient received product 11.65 9.97 25 206455 3452 90418515
Ballismus 11.65 9.97 6 206474 141 90421826
Hyperplasia adrenal 11.63 9.97 4 206476 32 90421935
Iliac artery stenosis 11.62 9.97 5 206475 77 90421890
Hypoosmolar state 11.59 9.97 7 206473 226 90421741
Diabetic metabolic decompensation 11.58 9.97 18 206462 1939 90420028
Pancreatitis acute 11.57 9.97 118 206362 31997 90389970
Defect conduction intraventricular 11.50 9.97 7 206473 229 90421738
Protein-losing gastroenteropathy 11.50 9.97 8 206472 330 90421637
Premature baby 11.47 9.97 25 206455 25052 90396915
Balloon atrial septostomy 11.45 9.97 5 206475 80 90421887
Throat tightness 11.45 9.97 32 206448 29452 90392515
Myalgia 11.40 9.97 498 205982 174627 90247340
Hypoperfusion 11.39 9.97 17 206463 1767 90420200
Petechiae 11.37 9.97 68 206412 15673 90406294
Hepatic neoplasm 11.34 9.97 19 206461 2179 90419788
Nephrocalcinosis 11.31 9.97 14 206466 1218 90420749
Hypertensive heart disease 11.27 9.97 21 206459 2619 90419348
QRS axis abnormal 11.25 9.97 14 206466 1224 90420743
Acute right ventricular failure 11.24 9.97 7 206473 239 90421728
Cerebral ischaemia 11.19 9.97 39 206441 7157 90414810
Immobilisation syndrome 11.18 9.97 9 206471 464 90421503
Respiratory tract infection 11.16 9.97 193 206287 58885 90363082
Infusion site erythema 11.15 9.97 61 206419 13609 90408358
Fibrinous bronchitis 11.12 9.97 3 206477 9 90421958
Haemoconcentration 11.10 9.97 6 206474 156 90421811
Chloasma 11.10 9.97 6 206474 156 90421811
Atrial thrombosis 11.05 9.97 19 206461 2226 90419741
Clostridium difficile colitis 11.04 9.97 101 206379 26605 90395362
Percutaneous coronary intervention 11.03 9.97 7 206473 247 90421720
Device dislocation 11.02 9.97 115 206365 31367 90390600
Hypoproteinaemia 11.01 9.97 23 206457 3119 90418848
Peripheral artery stenosis 10.99 9.97 10 206470 610 90421357
Colitis 10.98 9.97 104 206376 69838 90352129
Impaired quality of life 10.85 9.97 90 206390 23054 90398913
Cardiac valve thickening 10.85 9.97 4 206476 40 90421927
Gastrointestinal endoscopic therapy 10.85 9.97 4 206476 40 90421927
Blood pressure systolic increased 10.84 9.97 83 206397 58262 90363705
Interstitial lung disease 10.84 9.97 239 206241 76166 90345801
Blood magnesium decreased 10.84 9.97 67 206413 15626 90406341
Bundle branch block 10.83 9.97 12 206468 927 90421040
Electrocardiogram T wave peaked 10.81 9.97 7 206473 256 90421711
Yawning 10.79 9.97 13 206467 1099 90420868
Photophobia 10.76 9.97 20 206460 21249 90400718
Muscle twitching 10.76 9.97 93 206387 24109 90397858
Acute left ventricular failure 10.74 9.97 14 206466 1282 90420685
Chronic left ventricular failure 10.74 9.97 10 206470 628 90421339
Thrombotic microangiopathy 10.73 9.97 12 206468 15731 90406236
Deep vein thrombosis 10.70 9.97 279 206201 91341 90330626
Anal haemorrhage 10.68 9.97 20 206460 2504 90419463
Respiratory alkalosis 10.66 9.97 24 206456 3424 90418543
Dry gangrene 10.65 9.97 10 206470 635 90421332
External ear disorder 10.59 9.97 4 206476 43 90421924
Blood aldosterone abnormal 10.59 9.97 4 206476 43 90421924
Spondylitis 10.58 9.97 10 206470 14168 90407799
Face oedema 10.57 9.97 90 206390 23228 90398739
Thyroxine increased 10.46 9.97 11 206469 801 90421166
Somatostatin receptor scan abnormal 10.46 9.97 3 206477 12 90421955
Gonadotrophin deficiency 10.46 9.97 3 206477 12 90421955
Posterior reversible encephalopathy syndrome 10.45 9.97 22 206458 22317 90399650
Colon cancer 10.43 9.97 51 206429 10893 90411074
Pancreatolithiasis 10.43 9.97 7 206473 272 90421695
Femoral artery embolism 10.43 9.97 4 206476 45 90421922
Metastases to bone 10.42 9.97 27 206453 25478 90396489
Blood electrolytes abnormal 10.37 9.97 13 206467 1145 90420822
Platelet disorder 10.37 9.97 19 206461 2340 90419627
Conduction disorder 10.32 9.97 16 206464 1719 90420248
Vascular purpura 10.30 9.97 16 206464 1722 90420245
Alpha 1 foetoprotein increased 10.27 9.97 6 206474 182 90421785
Heparin-induced thrombocytopenia 10.26 9.97 31 206449 5281 90416686
Dialysis 10.24 9.97 52 206428 11277 90410690
Vascular stenosis 10.20 9.97 9 206471 527 90421440
Thrombosis in device 10.18 9.97 22 206458 3053 90418914
Right-to-left cardiac shunt 10.14 9.97 7 206473 285 90421682
Device occlusion 10.13 9.97 45 206435 9237 90412730
Hypocalvaria 10.12 9.97 4 206476 49 90421918
Oligodipsia 10.12 9.97 4 206476 49 90421918
Lethargy 10.10 9.97 201 206279 62938 90359029
Spinal fusion surgery 9.97 9.97 8 206472 12275 90409692

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperkalaemia 3075.42 10.82 2420 147246 78038 42393631
Acute kidney injury 1210.12 10.82 3410 146256 363927 42107742
Cardiac failure 900.09 10.82 1458 148208 105398 42366271
Hepatic encephalopathy 635.59 10.82 499 149167 15943 42455726
Hypotension 420.87 10.82 1904 147762 255727 42215942
Cardiac failure chronic 407.32 10.82 308 149358 9293 42462376
Ascites 398.01 10.82 714 148952 55964 42415705
Cardiac failure congestive 370.22 10.82 883 148783 84719 42386950
Drug ineffective 367.64 10.82 1073 148593 629124 41842545
Hyponatraemia 320.64 10.82 931 148735 100531 42371138
Hepatic cirrhosis 299.93 10.82 358 149308 19344 42452325
Oedema peripheral 295.48 10.82 1099 148567 134977 42336692
Gynaecomastia 279.81 10.82 279 149387 12288 42459381
Renal impairment 249.06 10.82 902 148764 109326 42362343
Hepatic failure 240.99 10.82 459 149207 37641 42434028
Dyspnoea 236.90 10.82 2482 147184 440139 42031530
Off label use 231.37 10.82 1309 148357 637026 41834643
Dehydration 230.97 10.82 1048 148618 140719 42330950
Drug abuse 228.70 10.82 45 149621 104726 42366943
Pulmonary hypertension 226.23 10.82 342 149324 23227 42448442
Ejection fraction decreased 209.87 10.82 319 149347 21768 42449901
Blood potassium increased 205.57 10.82 288 149378 18248 42453421
Right ventricular failure 205.13 10.82 208 149458 9347 42462322
N-terminal prohormone brain natriuretic peptide increased 183.48 10.82 127 149539 3326 42468343
Febrile neutropenia 181.97 10.82 231 149435 185472 42286197
Blood creatinine increased 167.84 10.82 798 148868 109205 42362464
Ventricular tachycardia 167.36 10.82 344 149322 29816 42441853
Completed suicide 166.69 10.82 65 149601 96400 42375269
Oesophageal varices haemorrhage 160.29 10.82 119 149547 3488 42468181
Renal failure 159.43 10.82 955 148711 142771 42328898
Drug interaction 157.05 10.82 1528 148138 265471 42206198
Hepatorenal syndrome 154.07 10.82 106 149560 2748 42468921
Pulmonary arterial hypertension 153.20 10.82 184 149482 10003 42461666
Congestive cardiomyopathy 153.10 10.82 171 149495 8593 42463076
Neutropenia 150.82 10.82 295 149371 199136 42272533
Toxicity to various agents 146.26 10.82 372 149294 228764 42242905
Cardiac failure acute 144.04 10.82 207 149459 13426 42458243
BRASH syndrome 143.75 10.82 86 149580 1739 42469930
Bradycardia 143.59 10.82 638 149028 84846 42386823
International normalised ratio increased 138.71 10.82 428 149238 47740 42423929
Mitral valve incompetence 134.35 10.82 222 149444 16267 42455402
Orthopnoea 131.29 10.82 126 149540 5291 42466378
Hepatocellular carcinoma 128.16 10.82 151 149515 8043 42463626
Orthostatic hypotension 124.12 10.82 308 149358 30262 42441407
Blood urea increased 121.33 10.82 319 149347 32474 42439195
Oedema 120.23 10.82 429 149237 51572 42420097
Atrial fibrillation 119.22 10.82 869 148797 138724 42332945
Therapeutic product effect incomplete 115.77 10.82 52 149614 70887 42400782
Brain natriuretic peptide increased 114.68 10.82 130 149536 6640 42465029
Syncope 112.36 10.82 664 149002 98742 42372927
Ischaemic cardiomyopathy 110.07 10.82 125 149541 6397 42465272
Chronic kidney disease 108.59 10.82 389 149277 46852 42424817
Arthralgia 108.49 10.82 364 149302 204874 42266795
Hepatic cancer 104.98 10.82 139 149527 8341 42463328
Product use in unapproved indication 103.86 10.82 318 149348 184138 42287531
General physical health deterioration 98.43 10.82 885 148781 150361 42321308
Hypokalaemia 97.01 10.82 503 149163 71218 42400451
Dyspnoea exertional 96.35 10.82 390 149276 49758 42421911
Varices oesophageal 95.48 10.82 96 149570 4269 42467400
Fluid retention 94.80 10.82 285 149381 31334 42440335
Atrioventricular block complete 91.23 10.82 152 149514 11212 42460457
Intentional product misuse 85.50 10.82 56 149610 61844 42409825
Intentional overdose 83.51 10.82 38 149628 51418 42420251
Treatment failure 83.37 10.82 59 149607 62565 42409104
Glomerular filtration rate decreased 83.14 10.82 180 149486 16171 42455498
Tricuspid valve incompetence 83.07 10.82 144 149522 10969 42460700
Gastrointestinal haemorrhage 82.58 10.82 607 149059 97119 42374550
Foetal exposure during pregnancy 81.49 10.82 32 149634 47279 42424390
Pyrexia 79.76 10.82 943 148723 393099 42078570
Bundle branch block left 78.39 10.82 105 149561 6371 42465298
Arrhythmia 76.21 10.82 312 149354 40005 42431664
Intentional product use issue 74.88 10.82 85 149581 71748 42399921
Blood pressure decreased 74.69 10.82 403 149263 57929 42413740
Fall 72.78 10.82 1192 148474 233328 42238341
Pain 70.85 10.82 536 149130 244312 42227357
Breast tenderness 69.73 10.82 41 149625 802 42470867
Rash 68.96 10.82 631 149035 276323 42195346
Melaena 68.67 10.82 294 149372 38452 42433217
Electrolyte imbalance 65.96 10.82 169 149497 16932 42454737
Blood bilirubin increased 64.69 10.82 307 149359 41945 42429724
Suicide attempt 64.63 10.82 41 149625 46059 42425610
Anxiety 64.13 10.82 208 149458 118352 42353317
Cardiomegaly 63.95 10.82 165 149501 16601 42455068
Ammonia increased 63.35 10.82 80 149586 4579 42467090
Infusion related reaction 63.32 10.82 72 149594 60734 42410935
Neuropathy peripheral 62.84 10.82 168 149498 101685 42369984
Electrocardiogram abnormal 62.60 10.82 121 149545 10024 42461645
Hypovolaemia 62.51 10.82 130 149536 11355 42460314
Hypervolaemia 61.52 10.82 200 149466 22925 42448744
Concomitant disease aggravated 60.96 10.82 94 149572 6492 42465177
Depression 59.11 10.82 197 149469 111166 42360503
COVID-19 58.25 10.82 210 149456 115738 42355931
Rheumatoid arthritis 57.79 10.82 39 149627 42401 42429268
Left ventricular dysfunction 57.77 10.82 126 149540 11375 42460294
Cardiac amyloidosis 57.03 10.82 51 149615 1954 42469715
Drug dependence 56.53 10.82 16 149650 29078 42442591
Suicidal ideation 55.84 10.82 52 149614 48109 42423560
Nipple pain 55.46 10.82 39 149627 1048 42470621
Injection site pain 55.37 10.82 73 149593 57725 42413944
Blood cholesterol 53.90 10.82 23 149643 217 42471452
Cardiomyopathy 53.70 10.82 169 149497 19041 42452628
Stress 52.13 10.82 47 149619 44165 42427504
Brain natriuretic peptide abnormal 51.91 10.82 26 149640 364 42471305
Congestive hepatopathy 51.39 10.82 52 149614 2330 42469339
Musculoskeletal stiffness 51.31 10.82 77 149589 57688 42413981
Jaundice 51.26 10.82 249 149417 34340 42437329
Urticaria 51.25 10.82 115 149551 73921 42397748
Breast pain 50.21 10.82 43 149623 1554 42470115
Atrioventricular block 50.20 10.82 107 149559 9508 42462161
Left ventricular dilatation 49.73 10.82 34 149632 872 42470797
Cytokine release syndrome 49.39 10.82 50 149616 44477 42427192
Glomerular filtration rate abnormal 49.23 10.82 38 149628 1182 42470487
Product dose omission issue 48.94 10.82 329 149337 154036 42317633
Loss of personal independence in daily activities 48.66 10.82 62 149604 49754 42421915
Pulmonary embolism 48.09 10.82 236 149430 119376 42352293
Anaemia 47.72 10.82 1305 148361 278973 42192696
Mucosal inflammation 47.66 10.82 62 149604 49312 42422357
Headache 47.09 10.82 576 149090 238793 42232876
Leukopenia 47.07 10.82 122 149544 74624 42397045
Thrombosis 46.95 10.82 107 149559 68404 42403265
Overdose 46.89 10.82 200 149466 105064 42366605
Low cardiac output syndrome 46.84 10.82 29 149637 625 42471044
Drug ineffective for unapproved indication 46.62 10.82 56 149610 46107 42425562
Sinusitis 46.05 10.82 59 149607 47233 42424436
Nodal rhythm 45.74 10.82 41 149625 1576 42470093
Seizure 45.56 10.82 243 149423 120318 42351351
Cytomegalovirus infection 44.91 10.82 29 149637 32277 42439392
Therapeutic drug monitoring analysis not performed 44.74 10.82 27 149639 555 42471114
Ventricular internal diameter abnormal 44.55 10.82 19 149647 179 42471490
Systemic infection 43.63 10.82 71 149595 5134 42466535
Therapeutic product effect decreased 43.38 10.82 44 149622 39106 42432563
Lactic acidosis 42.79 10.82 289 149377 44972 42426697
Metabolic acidosis 42.01 10.82 319 149347 51539 42420130
Intentional self-injury 41.75 10.82 3 149663 15199 42456470
Hyperhidrosis 41.53 10.82 170 149496 90342 42381327
Neuroleptic malignant syndrome 41.36 10.82 12 149654 21460 42450209
Joint swelling 41.33 10.82 113 149553 67909 42403760
Portal hypertension 41.09 10.82 66 149600 4721 42466948
Pulmonary congestion 40.90 10.82 135 149531 15595 42456074
Polyuria 40.76 10.82 101 149565 9910 42461759
Pneumonitis 40.67 10.82 52 149614 41666 42430003
Arthropathy 40.56 10.82 27 149639 29570 42442099
Pulmonary arterial pressure abnormal 40.41 10.82 21 149645 319 42471350
Blood sodium decreased 40.39 10.82 148 149518 18014 42453655
Electrocardiogram T wave peaked 40.29 10.82 28 149638 738 42470931
Synovitis 40.21 10.82 4 149662 15563 42456106
Sedation 40.17 10.82 29 149637 30446 42441223
Anuria 39.44 10.82 109 149557 11423 42460246
Generalised oedema 39.32 10.82 131 149535 15205 42456464
Myelosuppression 38.86 10.82 51 149615 40410 42431259
Appendicitis 38.83 10.82 12 149654 20601 42451068
Gastrointestinal disorder 38.77 10.82 65 149601 46588 42425081
Bradyarrhythmia 38.08 10.82 47 149619 2628 42469041
Cardioactive drug level increased 37.62 10.82 38 149628 1699 42469970
White blood cell count decreased 37.15 10.82 231 149435 110165 42361504
Chronic hepatic failure 36.85 10.82 25 149641 633 42471036
Product monitoring error 36.63 10.82 60 149606 4363 42467306
Type 2 diabetes mellitus 36.53 10.82 145 149521 18326 42453343
Left ventricular failure 36.08 10.82 71 149595 5960 42465709
Pulmonary oedema 35.75 10.82 314 149352 52958 42418711
Ventricular hypokinesia 35.24 10.82 76 149590 6808 42464861
Amyloidosis 35.24 10.82 43 149623 2376 42469293
Cardiogenic shock 35.16 10.82 230 149436 35410 42436259
Accidental exposure to product 34.77 10.82 14 149652 20379 42451290
Liver transplant 34.69 10.82 45 149621 2646 42469023
Hepatic function abnormal 34.63 10.82 304 149362 51263 42420406
Abdominal cavity drainage 34.61 10.82 21 149645 436 42471233
Tremor 34.09 10.82 200 149466 96729 42374940
Waist circumference increased 34.04 10.82 28 149638 956 42470713
Cirrhosis alcoholic 34.04 10.82 26 149640 796 42470873
Renin increased 33.97 10.82 16 149650 194 42471475
Somnolence 33.53 10.82 325 149341 140780 42330889
Blood potassium abnormal 33.18 10.82 36 149630 1750 42469919
Hypersensitivity 33.15 10.82 136 149530 72234 42399435
Pleural effusion 33.12 10.82 502 149164 96664 42375005
Neutrophil count decreased 33.07 10.82 113 149553 63302 42408367
Inability to afford medication 32.89 10.82 39 149627 2091 42469578
Subarachnoid haemorrhage 32.24 10.82 118 149548 14354 42457315
Troponin T increased 32.02 10.82 44 149622 2736 42468933
Genitalia external ambiguous 31.94 10.82 16 149650 224 42471445
Nasopharyngitis 31.89 10.82 169 149497 83827 42387842
Urine output decreased 31.63 10.82 97 149569 10776 42460893
Anaphylactic reaction 31.57 10.82 64 149602 42679 42428990
Sleep disorder due to a general medical condition 31.40 10.82 11 149655 17442 42454227
Arthritis 31.05 10.82 63 149603 42002 42429667
Malignant neoplasm progression 30.95 10.82 238 149428 108162 42363507
Oliguria 30.84 10.82 87 149579 9226 42462443
Upper gastrointestinal haemorrhage 30.78 10.82 197 149469 30102 42441567
Dyspnoea paroxysmal nocturnal 30.71 10.82 33 149633 1587 42470082
Colitis ulcerative 30.65 10.82 28 149638 26147 42445522
Iron deficiency anaemia 30.48 10.82 108 149558 12931 42458738
Diastolic dysfunction 30.08 10.82 72 149594 6911 42464758
Dizziness 29.90 10.82 1113 148553 248141 42223528
Portal hypertensive gastropathy 29.70 10.82 24 149642 799 42470870
Cardiac disorder 29.58 10.82 282 149384 48650 42423019
Adverse drug reaction 29.43 10.82 54 149612 37380 42434289
Pain in extremity 29.35 10.82 363 149303 150241 42321428
Myasthenia gravis 29.33 10.82 10 149656 16127 42455542
Multiple sclerosis relapse 29.32 10.82 7 149659 14257 42457412
Jugular vein distension 29.13 10.82 22 149644 662 42471007
Hepatitis C 29.11 10.82 90 149576 10043 42461626
Bronchopulmonary aspergillosis 29.03 10.82 16 149650 19413 42452256
N-terminal prohormone brain natriuretic peptide abnormal 28.97 10.82 15 149651 226 42471443
Chronic obstructive pulmonary disease 28.92 10.82 344 149322 62770 42408899
Keratoconus 28.72 10.82 13 149653 143 42471526
Sudden death 28.55 10.82 125 149541 16504 42455165
Incorrect route of product administration 28.46 10.82 26 149640 24279 42447390
Hallucination 28.30 10.82 105 149561 57402 42414267
Insomnia 28.24 10.82 272 149394 117981 42353688
Sopor 28.10 10.82 6 149660 13196 42458473
Paraesthesia 27.77 10.82 148 149518 73311 42398358
5-alpha-reductase deficiency 27.76 10.82 7 149659 7 42471662
Drug intolerance 27.72 10.82 167 149499 80257 42391412
Cardiac arrest 27.55 10.82 538 149128 108782 42362887
Respiratory depression 27.53 10.82 16 149650 18852 42452817
Graft versus host disease 27.25 10.82 6 149660 12919 42458750
Death 26.86 10.82 1367 148299 469818 42001851
Therapeutic response decreased 26.84 10.82 56 149610 36956 42434713
Premature baby 26.83 10.82 25 149641 23128 42448541
Pemphigoid 26.82 10.82 95 149571 11372 42460297
Adrenal adenoma 26.78 10.82 19 149647 518 42471151
Blood urea abnormal 26.69 10.82 26 149640 1112 42470557
Therapy partial responder 26.45 10.82 19 149647 20002 42451667
Akathisia 26.19 10.82 3 149663 10448 42461221
Prothrombin time prolonged 26.19 10.82 83 149583 9386 42462283
Neutrophil count increased 25.90 10.82 19 149647 19785 42451884
Bone marrow failure 25.78 10.82 48 149618 33045 42438624
Blood loss anaemia 25.71 10.82 84 149582 9652 42462017
Diaphragmatic spasm 25.66 10.82 11 149655 105 42471564
Hyperphosphataemia 25.54 10.82 7 149659 12997 42458672
Transplant rejection 25.43 10.82 8 149658 13580 42458089
Torsade de pointes 25.31 10.82 77 149589 8517 42463152
Peritonitis bacterial 25.29 10.82 67 149599 6848 42464821
Breast mass 25.09 10.82 21 149645 735 42470934
Ejection fraction 24.87 10.82 13 149653 200 42471469
Therapeutic drug monitoring analysis incorrectly performed 24.78 10.82 15 149651 310 42471359
Angina pectoris 24.78 10.82 199 149467 32697 42438972
Basal cell carcinoma 24.67 10.82 26 149640 22707 42448962
Acute myeloid leukaemia 24.67 10.82 25 149641 22231 42449438
Gastric varices 24.64 10.82 20 149646 670 42470999
Faecal volume decreased 24.36 10.82 13 149653 209 42471460
Presyncope 24.27 10.82 148 149518 22239 42449430
Periarthritis calcarea 24.24 10.82 10 149656 86 42471583
Bundle branch block right 24.22 10.82 73 149593 8033 42463636
Aggression 24.19 10.82 77 149589 44086 42427583
Embolic stroke 23.94 10.82 54 149612 4986 42466683
Articular calcification 23.84 10.82 10 149656 90 42471579
Metabolic alkalosis 23.82 10.82 33 149633 2068 42469601
Hypoaesthesia 23.79 10.82 150 149516 71313 42400356
Aspergillus infection 23.72 10.82 13 149653 15824 42455845
Liver disorder 23.72 10.82 228 149438 39416 42432253
Atrial enlargement 23.68 10.82 20 149646 709 42470960
Poisoning 23.62 10.82 11 149655 14688 42456981
Circulatory collapse 23.59 10.82 153 149513 23483 42448186
Generalised tonic-clonic seizure 23.58 10.82 35 149631 26344 42445325
Weight increased 23.47 10.82 520 149146 107463 42364206
Creatinine renal clearance decreased 23.41 10.82 44 149622 3569 42468100
Blood cholesterol increased 23.40 10.82 36 149630 26705 42444964
Scrotal oedema 23.31 10.82 31 149635 1868 42469801
Sudden cardiac death 23.24 10.82 46 149620 3878 42467791
Pancytopenia 23.23 10.82 283 149383 117460 42354209
Localised oedema 23.18 10.82 47 149619 4031 42467638
Portal vein thrombosis 23.03 10.82 50 149616 4499 42467170
Oxygen saturation increased 23.02 10.82 14 149652 292 42471377
Oesophageal variceal ligation 23.01 10.82 10 149656 99 42471570
Platelet count normal 22.96 10.82 7 149659 21 42471648
Coma hepatic 22.85 10.82 16 149650 427 42471242
Therapy non-responder 22.76 10.82 103 149563 53256 42418413
Osteonecrosis of jaw 22.75 10.82 20 149646 19029 42452640
Blood aldosterone increased 22.71 10.82 7 149659 22 42471647
Blood sodium abnormal 22.59 10.82 18 149648 587 42471082
Tinnitus 22.52 10.82 42 149624 28896 42442773
Nephrolithiasis 22.50 10.82 61 149605 36769 42434900
Dyskinesia 22.39 10.82 34 149632 25356 42446313
Haematemesis 22.37 10.82 182 149484 30017 42441652
Blood ketone body increased 22.24 10.82 17 149649 521 42471148
Hypoalbuminaemia 22.14 10.82 111 149555 15499 42456170
Blood pressure systolic decreased 22.11 10.82 52 149614 4935 42466734
Disease progression 22.07 10.82 363 149303 143293 42328376
Rhabdoid tumour 22.04 10.82 7 149659 25 42471644
Xanthopsia 22.02 10.82 11 149655 153 42471516
Angina unstable 21.94 10.82 89 149577 11359 42460310
Prostate cancer 21.65 10.82 82 149584 44561 42427108
Acute myocardial infarction 21.58 10.82 305 149361 57860 42413809
Migraine 21.49 10.82 35 149631 25379 42446290
Psoriatic arthropathy 21.48 10.82 34 149632 24933 42446736
Fractured coccyx 21.29 10.82 11 149655 165 42471504
Diplopia 21.20 10.82 24 149642 20292 42451377
Epistaxis 21.14 10.82 341 149325 66485 42405184
Quadriparesis 20.99 10.82 33 149633 2317 42469352
Injection site erythema 20.92 10.82 24 149642 20171 42451498
Enteritis 20.91 10.82 6 149660 10810 42460859
Abdominal distension 20.84 10.82 361 149305 71374 42400295
Subdural haematoma 20.83 10.82 146 149520 22992 42448677
Immune reconstitution inflammatory syndrome 20.80 10.82 5 149661 10138 42461531
Spur cell anaemia 20.80 10.82 8 149658 56 42471613
Injection site reaction 20.67 10.82 15 149651 15706 42455963
Protein-losing gastroenteropathy 20.49 10.82 15 149651 430 42471239
Therapeutic response shortened 20.49 10.82 11 149655 13543 42458126
Ejection fraction abnormal 20.47 10.82 24 149642 1271 42470398
Exercise tolerance decreased 20.41 10.82 57 149609 6009 42465660
Diabetic hyperosmolar coma 20.39 10.82 16 149650 510 42471159
Miosis 20.20 10.82 11 149655 13435 42458234
Cytomegalovirus infection reactivation 20.19 10.82 7 149659 11171 42460498
Adrenal cyst 20.18 10.82 11 149655 185 42471484
Neoplasm progression 20.09 10.82 45 149621 28955 42442714
Injection site swelling 20.06 10.82 18 149648 16955 42454714
Electrocardiogram QRS complex abnormal 19.90 10.82 15 149651 450 42471219
Rales 19.80 10.82 86 149580 11314 42460355
Thrombocytopenia 19.68 10.82 513 149153 189766 42281903
Oral lichen planus 19.66 10.82 11 149655 195 42471474
Acute pulmonary oedema 19.66 10.82 71 149595 8580 42463089
Neck pain 19.65 10.82 48 149618 29966 42441703
Memory impairment 19.64 10.82 100 149566 50122 42421547
Haemophagocytic lymphohistiocytosis 19.60 10.82 21 149645 18201 42453468
Left atrial enlargement 19.47 10.82 21 149645 1014 42470655
Paracentesis 19.37 10.82 15 149651 469 42471200
Impaired quality of life 19.33 10.82 13 149653 14164 42457505
Rhinitis 19.19 10.82 9 149657 11968 42459701
Blood phosphorus increased 19.17 10.82 10 149656 12515 42459154
Left ventricular hypertrophy 19.11 10.82 74 149592 9245 42462424
Alopecia 19.03 10.82 47 149619 29229 42442440
Back pain 19.00 10.82 367 149299 141409 42330260
Rhabdomyolysis 18.99 10.82 382 149284 77637 42394032
Psychotic disorder 18.90 10.82 47 149619 29161 42442508
Sinus arrest 18.88 10.82 30 149636 2126 42469543
Invasive ductal breast carcinoma 18.79 10.82 8 149658 75 42471594
Haematoma 18.70 10.82 165 149501 27858 42443811
Hydrocholecystis 18.70 10.82 15 149651 494 42471175
Eosinophilia 18.61 10.82 187 149479 32712 42438957
Neurological symptom 18.49 10.82 6 149660 9985 42461684
International normalised ratio decreased 18.48 10.82 46 149620 4526 42467143
Abdominal discomfort 18.43 10.82 172 149494 75083 42396586
Product storage error 18.42 10.82 8 149658 11132 42460537
International normalised ratio fluctuation 18.42 10.82 23 149643 1301 42470368
Chills 18.20 10.82 227 149439 93839 42377830
Erysipelas 18.16 10.82 56 149610 6240 42465429
Uveitis 18.15 10.82 5 149661 9253 42462416
Hydrothorax 18.11 10.82 16 149650 603 42471066
Haematotoxicity 17.99 10.82 8 149658 10977 42460692
Myasthenic syndrome 17.85 10.82 18 149648 803 42470866
Product prescribing error 17.56 10.82 154 149512 25958 42445711
Prerenal failure 17.50 10.82 31 149635 2402 42469267
Micturition urgency 17.49 10.82 10 149656 11888 42459781
Ventricular extrasystoles 17.46 10.82 93 149573 13297 42458372
Nephrogenic anaemia 17.39 10.82 32 149634 2554 42469115
Sinus bradycardia 17.26 10.82 100 149566 14753 42456916
Asthma 17.22 10.82 138 149528 62176 42409493
Vision blurred 17.21 10.82 114 149552 53585 42418084
Poisoning deliberate 17.21 10.82 7 149659 10127 42461542
Bacterial infection 17.16 10.82 46 149620 27833 42443836
Thrombotic microangiopathy 17.08 10.82 16 149650 14766 42456903
Stomatitis 17.08 10.82 105 149561 50224 42421445
Agitation 17.06 10.82 144 149522 64170 42407499
Hypochromic anaemia 17.05 10.82 20 149646 1060 42470609
Inferior vena cava syndrome 16.99 10.82 7 149659 60 42471609
Pericardial calcification 16.97 10.82 6 149660 32 42471637
Immune effector cell-associated neurotoxicity syndrome 16.96 10.82 6 149660 9455 42462214
Inappropriate schedule of product administration 16.89 10.82 236 149430 95666 42376003
Labelled drug-drug interaction medication error 16.88 10.82 103 149563 15479 42456190
Swelling 16.86 10.82 118 149548 54767 42416902
Agranulocytosis 16.83 10.82 173 149493 30439 42441230
Asthenia 16.82 10.82 1173 148493 279620 42192049
Base excess decreased 16.81 10.82 10 149656 200 42471469
Immature granulocyte count increased 16.80 10.82 11 149655 262 42471407
Blood chloride increased 16.78 10.82 38 149628 3518 42468151
Fluid intake reduced 16.75 10.82 41 149625 3991 42467678
Cardioversion 16.58 10.82 19 149647 982 42470687
Left atrial dilatation 16.50 10.82 30 149636 2372 42469297
Bladder irrigation 16.50 10.82 7 149659 65 42471604
Feeling abnormal 16.45 10.82 161 149505 69625 42402044
Endometriosis male 16.40 10.82 5 149661 15 42471654
Nightmare 16.38 10.82 40 149626 24972 42446697
Azotaemia 16.34 10.82 52 149614 5892 42465777
Cystitis haemorrhagic 16.29 10.82 3 149663 7326 42464343
Infection 16.29 10.82 286 149380 111782 42359887
Transplant evaluation 16.27 10.82 14 149652 509 42471160
Testicular swelling 16.20 10.82 27 149639 1992 42469677
Peptic ulcer perforation 16.18 10.82 12 149654 351 42471318
Irritability 16.14 10.82 48 149618 28080 42443589
Apparent mineralocorticoid excess 16.14 10.82 7 149659 69 42471600
Haematuria 16.12 10.82 289 149377 57510 42414159
Dermatomyositis 15.98 10.82 24 149642 1619 42470050
Sleep disorder 15.98 10.82 101 149565 47994 42423675
Oesophageal carcinoma 15.98 10.82 7 149659 9689 42461980
Infected dermal cyst 15.94 10.82 18 149648 915 42470754
Pulmonary veno-occlusive disease 15.92 10.82 15 149651 615 42471054
Pancreatitis 15.89 10.82 88 149578 43180 42428489
Colitis 15.89 10.82 97 149569 46475 42425194
Transferrin saturation decreased 15.89 10.82 14 149652 526 42471143
Bladder cancer 15.84 10.82 22 149644 17025 42454644
Dry mouth 15.83 10.82 79 149587 39800 42431869
Atrioventricular block second degree 15.75 10.82 41 149625 4146 42467523
Influenza 15.70 10.82 141 149525 62034 42409635
Atrial flutter 15.62 10.82 109 149557 17142 42454527
Conduction disorder 15.49 10.82 30 149636 2488 42469181
Asthma-chronic obstructive pulmonary disease overlap syndrome 15.49 10.82 23 149643 1536 42470133
Hyperaldosteronism 15.47 10.82 10 149656 233 42471436
Hepatomegaly 15.46 10.82 82 149584 11703 42459966
Ankylosing spondylitis 15.45 10.82 3 149663 7053 42464616
Atrioventricular block first degree 15.37 10.82 54 149612 6437 42465232
Dyspnoea at rest 15.37 10.82 41 149625 4208 42467461
Tachycardia 15.33 10.82 256 149410 100831 42370838
Oropharyngeal pain 15.32 10.82 87 149579 42423 42429246
Diffuse large B-cell lymphoma 15.30 10.82 7 149659 9447 42462222
Impaired work ability 15.30 10.82 12 149654 12079 42459590
Forced expiratory volume decreased 15.19 10.82 4 149662 7626 42464043
Pneumocystis jirovecii pneumonia 15.16 10.82 42 149624 25139 42446530
Stasis dermatitis 15.13 10.82 20 149646 1198 42470471
Hepatic pain 15.04 10.82 23 149643 1577 42470092
Hallucination, auditory 15.04 10.82 18 149648 14846 42456823
BK virus infection 15.02 10.82 6 149660 8778 42462891
Tooth disorder 15.02 10.82 12 149654 11967 42459702
Frequent bowel movements 15.01 10.82 33 149633 21374 42450295
Electrocardiogram change 14.99 10.82 15 149651 663 42471006
Blood thyroid stimulating hormone abnormal 14.99 10.82 12 149654 394 42471275
Activated partial thromboplastin time shortened 14.96 10.82 13 149653 479 42471190
Herpes zoster 14.87 10.82 78 149588 38799 42432870
Diffuse vasculitis 14.85 10.82 7 149659 85 42471584
Porphyria acute 14.73 10.82 12 149654 404 42471265
Intracranial aneurysm 14.66 10.82 24 149642 1744 42469925
Blood potassium decreased 14.64 10.82 122 149544 20262 42451407
Loss of consciousness 14.53 10.82 426 149240 91928 42379741
Drug withdrawal syndrome 14.48 10.82 34 149632 21515 42450154
Nocturnal dyspnoea 14.46 10.82 14 149652 594 42471075
International normalised ratio abnormal 14.43 10.82 35 149631 3388 42468281
Myocardial fibrosis 14.41 10.82 20 149646 1255 42470414
Concomitant disease progression 14.41 10.82 29 149637 2474 42469195
Syringe issue 14.38 10.82 6 149660 8550 42463119
Transfusion 14.38 10.82 74 149592 10440 42461229
Drug hypersensitivity 14.33 10.82 254 149412 99135 42372534
Left ventricular false tendon 14.31 10.82 6 149660 54 42471615
Blood creatinine abnormal 14.28 10.82 33 149633 3096 42468573
Plasma cell myeloma 14.27 10.82 103 149563 47475 42424194
Encephalopathy 14.25 10.82 214 149452 41119 42430550
Serotonin syndrome 14.20 10.82 45 149621 25800 42445869
Prothrombin level increased 14.18 10.82 9 149657 203 42471466
Acute respiratory distress syndrome 14.15 10.82 56 149610 30052 42441617
Parkinsonism 14.14 10.82 10 149656 10613 42461056
Tuberculosis 14.12 10.82 9 149657 10090 42461579
Hypopnoea 14.12 10.82 5 149661 7877 42463792
Tricuspid valve replacement 14.09 10.82 5 149661 27 42471642
Hyperuricaemia 14.07 10.82 68 149598 9356 42462313
Cardiac output decreased 14.03 10.82 18 149648 1047 42470622
Electrolyte depletion 14.02 10.82 10 149656 275 42471394
Prothrombin level decreased 14.00 10.82 19 149647 1167 42470502
Nodule 13.98 10.82 14 149652 12520 42459149
Preternatural anus 13.97 10.82 7 149659 98 42471571
Secondary sexual characteristics absence 13.97 10.82 3 149663 0 42471669
Cytopenia 13.97 10.82 25 149641 17472 42454197
Lipoprotein (a) increased 13.96 10.82 11 149655 353 42471316
Schizophrenia 13.95 10.82 10 149656 10540 42461129
Child-Pugh-Turcotte score increased 13.94 10.82 5 149661 28 42471641
Eye pain 13.89 10.82 24 149642 17006 42454663
Systolic dysfunction 13.89 10.82 32 149634 2996 42468673
Hypoglycaemia 13.88 10.82 291 149375 59563 42412106
Influenza like illness 13.86 10.82 61 149605 31779 42439890
Neurotoxicity 13.83 10.82 40 149626 23611 42448058
Ataxia 13.83 10.82 22 149644 16103 42455566
End stage renal disease 13.82 10.82 23 149643 16535 42455134
Drug level decreased 13.81 10.82 9 149657 9968 42461701
Atrial pressure increased 13.79 10.82 5 149661 29 42471640
Blood test abnormal 13.74 10.82 15 149651 12891 42458778
Cataract 13.70 10.82 58 149608 30546 42441123
Burning feet syndrome 13.67 10.82 7 149659 103 42471566
Rash erythematous 13.65 10.82 62 149604 32029 42439640
Percussion test abnormal 13.65 10.82 5 149661 30 42471639
Subcutaneous haematoma 13.63 10.82 18 149648 1077 42470592
Blood alkaline phosphatase increased 13.61 10.82 179 149487 33418 42438251
Hypogammaglobulinaemia 13.59 10.82 13 149653 11878 42459791
Lung diffusion test abnormal 13.58 10.82 6 149660 62 42471607
Ulcer 13.57 10.82 23 149643 16418 42455251
Crepitations 13.52 10.82 34 149632 3367 42468302
Blood lactic acid decreased 13.50 10.82 6 149660 63 42471606
Ear infection 13.50 10.82 15 149651 12789 42458880
Dysgeusia 13.41 10.82 68 149598 34121 42437548
Dependence on oxygen therapy 13.36 10.82 9 149657 225 42471444
Fungal infection 13.34 10.82 31 149635 19691 42451978
Hypophosphataemia 13.32 10.82 34 149632 20911 42450758
Bronchiectasis 13.28 10.82 27 149639 17992 42453677
Red cell distribution width increased 13.24 10.82 54 149612 6910 42464759
Blood creatine increased 13.14 10.82 47 149619 5653 42466016
Paranoia 13.14 10.82 18 149648 14008 42457661
Bronchial hyperreactivity 13.14 10.82 24 149642 1905 42469764
Rectosigmoid cancer metastatic 13.12 10.82 4 149662 12 42471657
Heart transplant 13.10 10.82 17 149649 1000 42470669
Night sweats 13.02 10.82 32 149634 19937 42451732
Hepatotoxicity 13.01 10.82 45 149621 25122 42446547
Pneumonia 12.91 10.82 1292 148374 420857 42050812
Right ventricular dysfunction 12.89 10.82 20 149646 1389 42470280
Disease recurrence 12.83 10.82 57 149609 29621 42442048
Exposure during pregnancy 12.83 10.82 7 149659 8541 42463128
Withdrawal syndrome 12.82 10.82 20 149646 14755 42456914
Haemodynamic test abnormal 12.77 10.82 5 149661 37 42471632
Lymph nodes scan abnormal 12.77 10.82 5 149661 37 42471632
Dilatation ventricular 12.76 10.82 28 149638 2538 42469131
Blood pressure abnormal 12.73 10.82 69 149597 9929 42461740
Urine protein/creatinine ratio increased 12.68 10.82 15 149651 802 42470867
Hormone receptor positive breast cancer 12.65 10.82 5 149661 38 42471631
Scrotal swelling 12.61 10.82 21 149645 1548 42470121
Cerebral infarction 12.60 10.82 166 149500 31003 42440666
Fistula 12.59 10.82 6 149660 7906 42463763
Infected skin ulcer 12.53 10.82 24 149642 1974 42469695
Left ventricular enlargement 12.46 10.82 15 149651 817 42470852
Prescribed underdose 12.45 10.82 70 149596 10212 42461457
Lower respiratory tract infection 12.45 10.82 89 149577 41117 42430552
Mycobacterium ulcerans infection 12.44 10.82 6 149660 77 42471592
Brain oedema 12.44 10.82 24 149642 16303 42455366
NYHA classification 12.43 10.82 5 149661 40 42471629
Gastric ulcer 12.43 10.82 108 149558 18154 42453515
Hypophagia 12.37 10.82 147 149519 26809 42444860
Substance abuse 12.37 10.82 8 149658 8897 42462772
Cardiac hypertrophy 12.34 10.82 18 149648 1183 42470486
Infective pulmonary exacerbation of cystic fibrosis 12.33 10.82 6 149660 7812 42463857
Chronic graft versus host disease 12.30 10.82 3 149663 6022 42465647
Hepatic calcification 12.29 10.82 10 149656 336 42471333
Drug effective for unapproved indication 12.25 10.82 4 149662 6629 42465040
Pulmonary vein stenosis 12.22 10.82 5 149661 42 42471627
Ventricular arrhythmia 12.18 10.82 49 149617 6230 42465439
Dyspepsia 12.17 10.82 90 149576 41262 42430407
Shock haemorrhagic 12.09 10.82 98 149568 16144 42455525
Hypoparathyroidism secondary 12.02 10.82 8 149658 196 42471473
Device inappropriate shock delivery 12.02 10.82 5 149661 44 42471625
Venous oxygen saturation decreased 12.02 10.82 5 149661 44 42471625
Ventricular fibrillation 12.00 10.82 160 149506 29963 42441706
Deep vein thrombosis 11.96 10.82 194 149472 76763 42394906
Pacemaker generated arrhythmia 11.90 10.82 3 149663 3 42471666
Pulmonary hypertensive crisis 11.88 10.82 8 149658 200 42471469
Perineal infection 11.87 10.82 13 149653 639 42471030
Neuralgia 11.86 10.82 48 149618 25599 42446070
Erythema 11.85 10.82 291 149375 108502 42363167
Epstein-Barr virus infection 11.85 10.82 10 149656 9708 42461961
Aortic valve incompetence 11.84 10.82 50 149616 6498 42465171
Sinus arrhythmia 11.83 10.82 15 149651 862 42470807
Extrapyramidal disorder 11.76 10.82 25 149641 16387 42455282
Hypertension 11.72 10.82 474 149192 166730 42304939
Portal shunt procedure 11.69 10.82 4 149662 19 42471650
Contraindicated product administered 11.68 10.82 138 149528 25134 42446535
Hypertriglyceridaemia 11.65 10.82 11 149655 10115 42461554
Cardiorenal syndrome 11.61 10.82 15 149651 878 42470791
Restless legs syndrome 11.60 10.82 10 149656 9604 42462065
Vasculitis 11.59 10.82 30 149636 18364 42453305
Hot flush 11.53 10.82 40 149626 22311 42449358
Apheresis related complication 11.52 10.82 4 149662 20 42471649
Hypoglycaemic coma 11.51 10.82 28 149638 2716 42468953
Goitre 11.50 10.82 22 149644 1808 42469861
Coordination abnormal 11.50 10.82 7 149659 8043 42463626
Intracardiac thrombus 11.49 10.82 26 149640 2406 42469263
Wrong technique in product usage process 11.47 10.82 212 149454 42423 42429246
Toxic epidermal necrolysis 11.46 10.82 144 149522 26606 42445063
Dizziness postural 11.46 10.82 56 149610 7739 42463930
Pathogen resistance 11.44 10.82 14 149652 11436 42460233
Large intestine perforation 11.40 10.82 10 149656 9526 42462143
Product quality issue 11.39 10.82 29 149637 17853 42453816
Coronary artery bypass 11.38 10.82 40 149626 4770 42466899
Urine osmolarity decreased 11.38 10.82 5 149661 51 42471618
Ectopic ACTH syndrome 11.36 10.82 4 149662 21 42471648
Joint stiffness 11.35 10.82 16 149650 12306 42459363
Middle insomnia 11.32 10.82 56 149610 7777 42463892
Abnormal behaviour 11.31 10.82 51 149615 26400 42445269
Defect conduction intraventricular 11.30 10.82 11 149655 470 42471199
Postrenal failure 11.27 10.82 12 149654 571 42471098
Muscle haemorrhage 11.26 10.82 36 149630 4089 42467580
Squamous cell carcinoma of skin 11.26 10.82 17 149649 12709 42458960
Cardiac asthma 11.22 10.82 8 149658 220 42471449
Body mass index decreased 11.18 10.82 9 149657 298 42471371
Eye irritation 11.14 10.82 14 149652 11304 42460365
Muscle spasticity 11.12 10.82 5 149661 6817 42464852
Exostosis 11.12 10.82 3 149663 5628 42466041
Intervertebral disc degeneration 11.10 10.82 6 149660 7361 42464308
Glomerular filtration rate increased 11.10 10.82 14 149652 800 42470869
Optic nerve operation 11.09 10.82 11 149655 481 42471188
Pulmonary fibrosis 11.08 10.82 52 149614 26629 42445040
Oxygen consumption decreased 11.08 10.82 9 149657 302 42471367
Splinter haemorrhages 11.05 10.82 6 149660 100 42471569
Hyperbilirubinaemia 11.05 10.82 116 149550 20519 42451150
Haemoglobin decreased 11.05 10.82 570 149096 131901 42339768
Acute abdomen 11.02 10.82 23 149643 2014 42469655
Post procedural haemorrhage 11.02 10.82 63 149603 9249 42462420
Restlessness 11.01 10.82 59 149607 29190 42442479
Electrocardiogram T wave amplitude increased 11 10.82 6 149660 101 42471568
Upper respiratory tract inflammation 10.95 10.82 22 149644 1874 42469795
Rash pruritic 10.94 10.82 71 149595 33532 42438137
CSF protein abnormal 10.92 10.82 4 149662 24 42471645
Therapeutic embolisation 10.90 10.82 9 149657 309 42471360
Endocarditis 10.89 10.82 57 149609 8095 42463574
Systemic lupus erythematosus 10.88 10.82 10 149656 9314 42462355
Nervous system disorder 10.87 10.82 28 149638 17167 42454502

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperkalaemia 6102.69 10.10 4126 306502 131670 110147001
Acute kidney injury 3383.68 10.10 6237 304391 629193 109649478
Cardiac failure 2016.70 10.10 2558 308070 185068 110093603
Hyponatraemia 1325.04 10.10 2271 308357 215382 110063289
Hepatic encephalopathy 1084.91 10.10 781 309847 27475 110251196
Hypotension 1032.02 10.10 3524 307104 520325 109758346
Cardiac failure congestive 779.32 10.10 1467 309161 149533 110129138
Ascites 773.13 10.10 1119 309509 91689 110186982
Renal impairment 764.17 10.10 1656 308972 186789 110091882
Pulmonary arterial hypertension 720.48 10.10 652 309976 31916 110246755
Dehydration 709.10 10.10 2054 308574 277457 110001214
Drug interaction 705.66 10.10 3027 307601 497156 109781515
Synovitis 700.70 10.10 14 310614 274078 110004593
Right ventricular failure 657.07 10.10 561 310067 25393 110253278
Dyspnoea 626.12 10.10 5267 305361 1101605 109177066
Pulmonary hypertension 621.08 10.10 771 309857 54449 110224222
Cardiac failure chronic 602.85 10.10 413 310215 13398 110265273
Drug ineffective 598.61 10.10 2230 308398 1518310 108760361
Hand deformity 580.58 10.10 6 310622 218500 110060171
Renal failure 579.24 10.10 1670 308958 224904 110053767
Arthropathy 572.22 10.10 68 310560 287454 109991217
Infusion related reaction 546.49 10.10 194 310434 380968 109897703
Oedema peripheral 542.32 10.10 2089 308539 326571 109952100
Bradycardia 540.56 10.10 1286 309342 154231 110124440
Pemphigus 518.56 10.10 19 310609 214551 110064120
Joint swelling 496.27 10.10 316 310312 442529 109836142
Glossodynia 491.23 10.10 34 310594 221970 110056701
Atrial fibrillation 490.06 10.10 1589 309039 228053 110050618
Systemic lupus erythematosus 487.14 10.10 68 310560 254270 110024401
Blood creatinine increased 484.81 10.10 1366 309262 181523 110097148
Duodenal ulcer perforation 439.09 10.10 13 310615 177687 110100984
Helicobacter infection 429.71 10.10 19 310609 181858 110096813
Therapeutic product effect decreased 420.14 10.10 87 310541 244229 110034442
Maternal exposure during pregnancy 417.73 10.10 101 310527 254782 110023889
Folliculitis 411.58 10.10 13 310615 167640 110111031
International normalised ratio increased 403.44 10.10 807 309821 85965 110192706
Blood potassium increased 402.67 10.10 482 310146 32767 110245904
Drug intolerance 400.78 10.10 332 310296 406180 109872491
Treatment failure 397.41 10.10 141 310487 277093 110001578
Rheumatoid arthritis 389.32 10.10 177 310451 299436 109979235
Pericarditis 383.06 10.10 75 310553 219039 110059632
Muscle injury 368.90 10.10 5 310623 140802 110137869
Psoriatic arthropathy 366.58 10.10 57 310571 196704 110081967
Hepatic failure 363.30 10.10 675 309953 68064 110210607
Hypersensitivity 351.06 10.10 370 310258 403628 109875043
Wound 345.05 10.10 114 310514 234323 110044348
Musculoskeletal stiffness 342.73 10.10 179 310449 279643 109999028
Blood urea increased 331.86 10.10 572 310056 54385 110224286
Hepatic enzyme increased 328.86 10.10 252 310376 320640 109958031
Syncope 326.88 10.10 1279 309349 201257 110077414
Gynaecomastia 325.20 10.10 245 310383 9245 110269426
Off label use 323.43 10.10 2683 307945 1497502 108781169
Impaired healing 322.20 10.10 78 310550 196639 110082032
Irritable bowel syndrome 321.30 10.10 41 310587 164174 110114497
Alopecia 320.32 10.10 331 310297 364422 109914249
Pain 311.01 10.10 1503 309125 953452 109325219
C-reactive protein abnormal 298.48 10.10 16 310612 129679 110148992
N-terminal prohormone brain natriuretic peptide increased 295.80 10.10 195 310433 5926 110272745
Ventricular tachycardia 290.88 10.10 512 310116 49497 110229174
Fluid retention 288.57 10.10 743 309885 93564 110185107
Drug abuse 281.58 10.10 75 310553 177336 110101335
Bursitis 281.32 10.10 22 310606 129896 110148775
Arthralgia 280.65 10.10 1182 309446 778450 109500221
Hypervolaemia 279.47 10.10 500 310128 48960 110229711
Dyspnoea exertional 279.27 10.10 781 309847 103279 110175392
Lower respiratory tract infection 276.89 10.10 170 310458 242936 110035735
BRASH syndrome 276.09 10.10 156 310472 3567 110275104
Cardiac failure acute 275.19 10.10 339 310289 23739 110254932
Hypokalaemia 270.30 10.10 1122 309506 181326 110097345
Anaemia 269.22 10.10 2529 308099 544557 109734114
Joint range of motion decreased 268.45 10.10 19 310609 121813 110156858
Blood cholesterol increased 266.42 10.10 93 310535 184692 110093979
Stomatitis 262.15 10.10 224 310404 270018 110008653
Orthopnoea 254.30 10.10 226 310402 10795 110267876
Abdominal discomfort 249.50 10.10 453 310175 393405 109885266
Chronic kidney disease 249.00 10.10 616 310012 75675 110202996
Ill-defined disorder 245.74 10.10 68 310560 156785 110121886
Gastrointestinal haemorrhage 242.91 10.10 1015 309613 164503 110114168
Discomfort 240.55 10.10 153 310475 214554 110064117
Melaena 239.18 10.10 569 310059 68188 110210483
Lip dry 237.87 10.10 10 310618 100073 110178598
Completed suicide 234.97 10.10 201 310427 242180 110036491
Drug hypersensitivity 229.83 10.10 592 310036 453498 109825173
Exposure during pregnancy 226.77 10.10 93 310535 167331 110111340
Sinusitis 226.29 10.10 301 310327 296387 109982284
Contraindicated product administered 221.61 10.10 222 310406 248045 110030626
Hepatocellular carcinoma 218.86 10.10 198 310430 9682 110268989
Fall 217.77 10.10 2621 308007 600861 109677810
Urticaria 217.25 10.10 350 310278 318507 109960164
Brain natriuretic peptide increased 216.25 10.10 208 310420 11001 110267670
Mobility decreased 215.72 10.10 209 310419 237213 110041458
Congestive cardiomyopathy 214.42 10.10 231 310397 13988 110264683
Ejection fraction decreased 212.93 10.10 399 310229 40481 110238190
Rash 212.69 10.10 1392 309236 819572 109459099
Oesophageal varices haemorrhage 209.03 10.10 145 310483 4800 110273871
Febrile neutropenia 205.37 10.10 359 310269 316408 109962263
Product use in unapproved indication 203.55 10.10 614 310014 446763 109831908
Swelling 203.01 10.10 426 310202 350615 109928056
Orthostatic hypotension 201.66 10.10 521 310107 65728 110212943
Blood pressure decreased 201.39 10.10 746 309882 114345 110164326
Atrioventricular block complete 199.92 10.10 264 310364 19818 110258853
Hepatorenal syndrome 199.50 10.10 137 310491 4460 110274211
Hepatic cirrhosis 197.85 10.10 524 310104 67102 110211569
Glomerular filtration rate decreased 197.02 10.10 318 310310 28638 110250033
Nasopharyngitis 195.79 10.10 519 310109 393842 109884829
Intentional product use issue 194.70 10.10 246 310382 247660 110031011
Osteoarthritis 192.69 10.10 139 310489 182484 110096187
Grip strength decreased 190.57 10.10 8 310620 80166 110198505
Cardiac disorder 187.69 10.10 555 310073 75725 110202946
Gastrointestinal disorder 187.00 10.10 243 310385 241709 110036962
Mitral valve incompetence 185.81 10.10 335 310293 32994 110245677
Sleep disorder due to general medical condition, insomnia type 184.91 10.10 36 310592 105607 110173064
Injury 183.04 10.10 138 310490 177127 110101544
Night sweats 178.90 10.10 76 310552 133907 110144764
Blister 175.06 10.10 229 310399 227147 110051524
Hypoaesthesia 172.84 10.10 392 310236 313831 109964840
Atrioventricular block 171.31 10.10 224 310404 16653 110262018
Arrhythmia 170.02 10.10 505 310123 69070 110209601
Sleep disorder 168.96 10.10 185 310443 198459 110080212
Liver injury 165.97 10.10 109 310519 150304 110128367
Live birth 164.93 10.10 7 310621 69477 110209194
Polycystic ovaries 164.74 10.10 124 310504 4672 110273999
Sensitisation 162.18 10.10 116 310512 4035 110274636
Blood bilirubin increased 162.09 10.10 526 310102 75446 110203225
Varices oesophageal 158.66 10.10 144 310484 7071 110271600
Ejection fraction 157.20 10.10 100 310528 2855 110275816
Product prescribing error 156.55 10.10 404 310224 50927 110227744
Wound infection 152.62 10.10 41 310587 96424 110182247
Lactic acidosis 151.95 10.10 589 310039 92222 110186449
Fibromyalgia 151.14 10.10 154 310474 170755 110107916
Dry mouth 150.22 10.10 205 310423 199743 110078928
Cardiomegaly 150.06 10.10 283 310345 28847 110249824
Tricuspid valve incompetence 148.74 10.10 252 310376 23621 110255050
Ischaemic cardiomyopathy 147.68 10.10 145 310483 7866 110270805
Paraesthesia 146.41 10.10 352 310276 276169 110002502
Cardioactive drug level increased 146.00 10.10 106 310522 3776 110274895
Toxicity to various agents 142.01 10.10 781 309847 479774 109798897
Hypovolaemia 141.99 10.10 234 310394 21440 110257231
Arthritis 141.49 10.10 157 310471 167429 110111242
Electrolyte imbalance 140.36 10.10 317 310311 36711 110241960
Hypercholesterolaemia 137.45 10.10 42 310586 90795 110187876
Product use issue 135.16 10.10 437 310191 311258 109967413
Inflammation 132.59 10.10 211 310417 193027 110085644
Pulmonary oedema 131.35 10.10 596 310032 100063 110178608
Pleural effusion 129.94 10.10 900 309728 176809 110101862
Renal disorder 129.41 10.10 368 310260 49111 110229560
Therapeutic product effect incomplete 128.97 10.10 272 310356 223533 110055138
Blepharospasm 128.63 10.10 6 310622 54845 110223826
Product monitoring error 127.59 10.10 141 310487 8786 110269885
Type 2 diabetes mellitus 125.93 10.10 189 310439 177043 110101628
Peripheral venous disease 125.29 10.10 40 310588 84077 110194594
Cardiogenic shock 125.04 10.10 400 310228 56938 110221733
Blood sodium decreased 123.52 10.10 308 310320 38011 110240660
Gait inability 121.58 10.10 122 310506 136254 110142417
Concomitant disease aggravated 120.00 10.10 186 310442 16178 110262493
Ejection fraction abnormal 117.83 10.10 89 310539 3371 110275300
Bundle branch block left 116.99 10.10 162 310466 12726 110265945
Hepatic cancer 114.68 10.10 149 310479 11007 110267664
Intentional overdose 114.20 10.10 122 310506 132379 110146292
Cardiomyopathy 113.94 10.10 275 310353 33250 110245421
Bone erosion 112.34 10.10 4 310624 46367 110232304
Infection 111.75 10.10 580 310048 361620 109917051
Lower limb fracture 110.16 10.10 37 310591 75311 110203360
Sciatica 108.83 10.10 62 310566 92337 110186334
Myelosuppression 108.71 10.10 65 310563 94275 110184396
Obesity 108.57 10.10 95 310533 113256 110165415
Red blood cell sedimentation rate increased 106.81 10.10 43 310585 78259 110200412
Metabolic acidosis 106.74 10.10 558 310070 99186 110179485
Neutropenia 106.73 10.10 616 310012 374004 109904667
Hepatic function abnormal 105.73 10.10 514 310114 88781 110189890
Labelled drug-drug interaction medication error 105.69 10.10 246 310382 29056 110249615
Nail disorder 102.96 10.10 19 310609 57916 110220755
Ammonia increased 102.18 10.10 121 310507 8129 110270542
Epistaxis 100.50 10.10 669 309959 129703 110148968
Atrial flutter 100.21 10.10 215 310413 24047 110254624
Haematemesis 99.92 10.10 379 310249 58729 110219942
Pulmonary congestion 99.92 10.10 249 310379 30717 110247954
Haematoma 99.73 10.10 376 310252 58100 110220571
Pyrexia 99.46 10.10 1851 308777 896414 109382257
Injection site reaction 98.99 10.10 64 310564 89006 110189665
Onychomadesis 98.09 10.10 8 310620 45655 110233016
Jaundice 97.82 10.10 377 310251 58859 110219812
Upper gastrointestinal haemorrhage 96.36 10.10 335 310293 49761 110228910
Generalised oedema 95.01 10.10 243 310385 30461 110248210
Autoimmune disorder 94.27 10.10 33 310595 65450 110213221
Congestive hepatopathy 93.47 10.10 93 310535 5127 110273544
Transfusion 93.14 10.10 215 310413 25257 110253414
Colitis ulcerative 90.98 10.10 52 310576 77311 110201360
Electrocardiogram abnormal 90.52 10.10 177 310451 18532 110260139
Migraine 90.43 10.10 219 310409 171433 110107238
Pain in jaw 89.71 10.10 332 310296 50845 110227826
Therapeutic drug monitoring analysis not performed 89.64 10.10 60 310568 1871 110276800
Prescribed overdose 89.34 10.10 69 310559 87512 110191159
Left ventricular failure 88.52 10.10 133 310495 11256 110267415
Polyuria 88.49 10.10 170 310458 17568 110261103
Prothrombin time prolonged 88.05 10.10 167 310461 17094 110261577
Knee arthroplasty 88.04 10.10 36 310592 64912 110213759
Hip arthroplasty 87.76 10.10 24 310604 55789 110222882
Rhabdomyolysis 87.53 10.10 609 310019 119792 110158879
Road traffic accident 86.98 10.10 104 310524 107294 110171377
X-ray abnormal 86.76 10.10 5 310623 38112 110240559
Wheezing 84.85 10.10 398 310230 254832 110023839
Adverse drug reaction 83.60 10.10 104 310524 105455 110173216
Pulmonary fibrosis 83.51 10.10 98 310530 101944 110176727
Anuria 83.07 10.10 200 310428 24141 110254530
Product quality issue 79.99 10.10 60 310568 77239 110201432
Anxiety 78.87 10.10 606 310022 344472 109934199
Haemoglobin decreased 78.68 10.10 1055 309573 247672 110030999
Pemphigoid 78.38 10.10 172 310456 19535 110259136
Portal hypertension 77.55 10.10 108 310520 8529 110270142
Injection site pain 77.39 10.10 249 310379 177673 110100998
Inability to afford medication 75.55 10.10 74 310554 4002 110274669
Oedema 75.47 10.10 912 309716 209064 110069607
Epilepsy 74.98 10.10 103 310525 100106 110178565
Coeliac disease 74.97 10.10 15 310613 43172 110235499
Left ventricular dysfunction 73.80 10.10 187 310441 23306 110255365
Oliguria 73.26 10.10 162 310466 18495 110260176
Cardiac arrest 73.10 10.10 860 309768 195893 110082778
Pregnancy 73.06 10.10 26 310602 51041 110227630
Sinus node dysfunction 72.25 10.10 107 310521 8940 110269731
Subdural haematoma 72.05 10.10 246 310382 36208 110242463
Urine output decreased 71.83 10.10 167 310461 19709 110258962
Sleep apnoea syndrome 71.40 10.10 263 310365 40184 110238487
Systemic infection 71.15 10.10 111 310517 9708 110268963
C-reactive protein increased 70.56 10.10 343 310285 217576 110061095
Pericardial effusion 70.36 10.10 333 310295 56884 110221787
Exostosis 69.97 10.10 21 310607 45935 110232736
Depression 69.85 10.10 563 310065 316772 109961899
Sudden death 69.28 10.10 187 310441 24208 110254463
Metabolic alkalosis 69.19 10.10 82 310546 5513 110273158
Renin increased 68.88 10.10 29 310599 337 110278334
Musculoskeletal pain 68.39 10.10 273 310355 182750 110095921
Dyspepsia 68.14 10.10 290 310338 190675 110087996
Vital capacity decreased 67.68 10.10 52 310576 2021 110276650
Cardiac amyloidosis 67.09 10.10 59 310569 2778 110275893
General physical health deterioration 66.85 10.10 1615 309013 423680 109854991
Ischaemic stroke 66.81 10.10 261 310367 41002 110237669
Pulmonary arterial pressure increased 66.50 10.10 77 310551 5050 110273621
Paracentesis 66.19 10.10 44 310584 1356 110277315
Onychomycosis 65.61 10.10 14 310614 38517 110240154
Muscle spasticity 65.52 10.10 11 310617 35904 110242767
Low cardiac output syndrome 65.32 10.10 40 310588 1066 110277605
Blood potassium decreased 65.13 10.10 313 310315 53801 110224870
Intentional product misuse 65.03 10.10 176 310452 132728 110145943
Back injury 64.69 10.10 26 310602 47373 110231298
Brain natriuretic peptide abnormal 64.52 10.10 37 310591 871 110277800
Sputum culture positive 63.65 10.10 66 310562 3823 110274848
Joint stiffness 63.62 10.10 57 310571 67186 110211485
Iron deficiency anaemia 63.28 10.10 214 310414 31345 110247326
Inappropriate antidiuretic hormone secretion 63.06 10.10 224 310404 33627 110245044
Pulmonary arterial pressure abnormal 62.85 10.10 37 310591 916 110277755
Dizziness 62.78 10.10 2476 308152 695717 109582954
Hypoglycaemia 62.10 10.10 547 310081 115557 110163114
Chronic obstructive pulmonary disease 61.38 10.10 520 310108 108638 110170033
Prerenal failure 61.27 10.10 69 310559 4390 110274281
Taste disorder 61.17 10.10 56 310572 65331 110213340
Bundle branch block right 60.34 10.10 117 310511 12174 110266497
Shock haemorrhagic 60.23 10.10 191 310437 27056 110251615
Anaphylactic reaction 60.05 10.10 146 310482 114154 110164517
Incorrect route of product administration 59.77 10.10 55 310573 64006 110214665
Liver transplant 59.65 10.10 69 310559 4520 110274151
Foot deformity 59.31 10.10 31 310597 48449 110230222
Glomerular filtration rate abnormal 59.26 10.10 51 310577 2332 110276339
Therapy non-responder 59.18 10.10 234 310394 157073 110121598
Bradyarrhythmia 58.86 10.10 71 310557 4863 110273808
Sinus bradycardia 58.30 10.10 199 310429 29284 110249387
Hypovolaemic shock 57.68 10.10 127 310501 14456 110264215
Reversible airways obstruction 57.16 10.10 51 310577 2448 110276223
Circulatory collapse 57.14 10.10 256 310372 42737 110235934
Memory impairment 57.02 10.10 322 310306 196622 110082049
Catheter management 56.88 10.10 61 310567 3674 110274997
Abdominal cavity drainage 56.51 10.10 34 310594 877 110277794
Acute myocardial infarction 56.39 10.10 416 310212 83361 110195310
Abdominal distension 56.29 10.10 745 309883 174358 110104313
Nodal rhythm 55.85 10.10 58 310570 3365 110275306
Dyspnoea paroxysmal nocturnal 55.14 10.10 50 310578 2452 110276219
Hypertension 55.09 10.10 1055 309573 509029 109769642
Atrial tachycardia 54.70 10.10 95 310533 9083 110269588
Blood alkaline phosphatase increased 54.64 10.10 364 310264 70571 110208100
Lung disorder 54.53 10.10 290 310338 179757 110098914
Body tinea 54.10 10.10 46 310582 2069 110276602
Waist circumference increased 54.09 10.10 43 310585 1758 110276913
Nipple pain 53.86 10.10 36 310592 1120 110277551
Ear infection 53.78 10.10 58 310570 62674 110215997
Injection site erythema 53.77 10.10 115 310513 94061 110184610
Therapeutic response decreased 53.31 10.10 120 310508 96379 110182292
Acute pulmonary oedema 53.09 10.10 135 310493 16861 110261810
Cirrhosis alcoholic 53.08 10.10 35 310593 1064 110277607
Blood aldosterone increased 53.02 10.10 21 310607 206 110278465
Cytomegalovirus infection 52.90 10.10 45 310583 54399 110224272
Electrocardiogram T wave peaked 52.85 10.10 36 310592 1156 110277515
N-terminal prohormone brain natriuretic peptide abnormal 52.26 10.10 23 310605 300 110278371
Blood loss anaemia 52.02 10.10 139 310489 17886 110260785
Intentional self-injury 51.95 10.10 20 310608 37409 110241262
Product label confusion 51.54 10.10 3 310625 22674 110255997
Lupus-like syndrome 51.53 10.10 25 310603 40767 110237904
Rhinitis allergic 51.52 10.10 138 310490 17784 110260887
Embolic stroke 51.46 10.10 90 310538 8653 110270018
Peritonitis bacterial 51.38 10.10 100 310528 10433 110268238
Drug tolerance decreased 51.21 10.10 8 310620 27532 110251139
Stress 51.17 10.10 140 310488 105208 110173463
Neck pain 51.01 10.10 176 310452 122954 110155717
Nephrectomy 50.94 10.10 49 310579 2591 110276080
Cor pulmonale 50.86 10.10 46 310582 2248 110276423
Frequent bowel movements 50.81 10.10 76 310552 71314 110207357
Psoriasis 50.30 10.10 212 310416 139781 110138890
Cytokine release syndrome 49.89 10.10 75 310553 70231 110208440
Hepatitis C 49.17 10.10 109 310519 12464 110266207
Suicide attempt 49.03 10.10 139 310489 103255 110175416
Sinoatrial block 48.38 10.10 37 310591 1428 110277243
Ventricular hypokinesia 48.19 10.10 101 310527 11113 110267558
Poisoning deliberate 48.17 10.10 8 310620 26323 110252348
Palpitations 48.14 10.10 670 309958 158542 110120129
Hypothyroidism 47.93 10.10 360 310268 72539 110206132
Ventricular internal diameter abnormal 47.92 10.10 20 310608 227 110278444
Chest pain 47.80 10.10 1390 309238 374985 109903686
Pain in extremity 47.67 10.10 1024 309604 486094 109792577
Atrioventricular block first degree 47.60 10.10 116 310512 14109 110264562
Blood creatine increased 47.47 10.10 102 310526 11419 110267252
Acute respiratory failure 47.44 10.10 368 310260 74892 110203779
Portal vein thrombosis 47.31 10.10 77 310551 6981 110271690
Insomnia 47.27 10.10 720 309908 359870 109918801
Left ventricular dilatation 47.15 10.10 36 310592 1386 110277285
Suicidal ideation 47.01 10.10 123 310505 93814 110184857
Atrial enlargement 46.90 10.10 33 310595 1118 110277553
Torsade de pointes 46.86 10.10 155 310473 22445 110256226
Gamma-glutamyltransferase increased 46.86 10.10 314 310314 60995 110217676
Dizziness postural 46.63 10.10 117 310511 14492 110264179
Catheter site infection 46.63 10.10 82 310546 7918 110270753
Concomitant disease progression 46.46 10.10 54 310574 3556 110275115
Chronic hepatic failure 46.20 10.10 34 310594 1237 110277434
Inhibitory drug interaction 46.13 10.10 63 310565 4884 110273787
Carpal tunnel syndrome 45.93 10.10 154 310474 22456 110256215
Presyncope 45.91 10.10 264 310364 48623 110230048
Jugular vein distension 45.17 10.10 37 310591 1579 110277092
Shock 44.96 10.10 281 310347 53307 110225364
Ventricular fibrillation 44.79 10.10 232 310396 41081 110237590
Spur cell anaemia 44.37 10.10 16 310612 118 110278553
Mucosal inflammation 44.31 10.10 131 310497 96010 110182661
Cerebral infarction 44.23 10.10 273 310355 51565 110227106
Loss of consciousness 44.13 10.10 786 309842 195520 110083151
Portal hypertensive gastropathy 43.77 10.10 39 310589 1869 110276802
Breast tenderness 43.56 10.10 45 310583 2595 110276076
Urinary retention 43.52 10.10 340 310288 69343 110209328
Respiratory failure 43.49 10.10 848 309780 214484 110064187
Subarachnoid haemorrhage 43.41 10.10 182 310446 29520 110249151
Hyperbilirubinaemia 43.32 10.10 186 310442 30485 110248186
Cardioversion 42.73 10.10 42 310586 2281 110276390
Asthma 42.66 10.10 473 310155 249818 110028853
Hypophagia 42.33 10.10 273 310355 52353 110226318
Aortic valve incompetence 41.60 10.10 94 310534 10887 110267784
Adrenal adenoma 41.37 10.10 34 310594 1458 110277213
Adverse reaction 40.77 10.10 16 310612 29578 110249093
Lichen planopilaris 40.67 10.10 16 310612 154 110278517
Drug ineffective for unapproved indication 40.59 10.10 150 310478 102688 110175983
Erysipelas 40.56 10.10 104 310524 13054 110265617
Liver function test increased 40.56 10.10 121 310507 88427 110190244
Dyspnoea at rest 40.42 10.10 79 310549 8267 110270404
Immunodeficiency 40.37 10.10 30 310598 38808 110239863
Haematuria 40.29 10.10 383 310245 82622 110196049
Electrocardiogram QRS complex prolonged 40.23 10.10 103 310525 12918 110265753
Oxygen saturation decreased 40.19 10.10 642 309986 156340 110122331
Azotaemia 40.08 10.10 88 310540 9997 110268674
Purpura 40.08 10.10 155 310473 24233 110254438
Ventricular extrasystoles 39.78 10.10 147 310481 22494 110256177
Device related infection 39.49 10.10 217 310411 39302 110239369
Neuropathy peripheral 39.45 10.10 318 310310 178959 110099712
Hepatomegaly 39.28 10.10 141 310487 21273 110257398
Cardiac output decreased 39.17 10.10 38 310590 2031 110276640
Haemoptysis 39.10 10.10 338 310290 71016 110207655
Hyperuricaemia 38.89 10.10 109 310519 14422 110264249
Progressive multifocal leukoencephalopathy 38.73 10.10 11 310617 24945 110253726
Neuroleptic malignant syndrome 38.49 10.10 24 310604 34035 110244636
Hypoalbuminaemia 38.11 10.10 172 310456 28802 110249869
Catheterisation cardiac 38.10 10.10 65 310563 6126 110272545
Sinus arrest 38.02 10.10 53 310575 4189 110274482
Exercise tolerance decreased 37.85 10.10 96 310532 11971 110266700
Peripheral circulatory failure 37.46 10.10 35 310593 1784 110276887
Agranulocytosis 37.28 10.10 299 310329 61461 110217210
Localised oedema 37.25 10.10 81 310547 9142 110269529
Blood pressure systolic decreased 37.14 10.10 102 310526 13339 110265332
Bronchial secretion retention 36.69 10.10 57 310571 4967 110273704
Gastric polyps 36.68 10.10 60 310568 5463 110273208
Oesophageal variceal ligation 36.60 10.10 15 310613 162 110278509
Adverse event 36.53 10.10 169 310459 108640 110170031
Blood urea abnormal 36.26 10.10 35 310593 1859 110276812
Multiple sclerosis relapse 36.23 10.10 53 310575 50187 110228484
Cardiorenal syndrome 35.88 10.10 35 310593 1883 110276788
Multiple allergies 35.83 10.10 95 310533 12168 110266503
Hyperthyroidism 35.75 10.10 170 310458 29091 110249580
Ulcer 35.71 10.10 41 310587 43075 110235596
Hyperglycaemia 35.70 10.10 381 310247 84709 110193962
Myocardial infarction 35.65 10.10 747 309881 191336 110087335
Ventricular arrhythmia 35.63 10.10 84 310544 10003 110268668
Laryngitis 35.48 10.10 40 310588 42371 110236300
Walking aid user 35.47 10.10 13 310615 25062 110253609
Transplant evaluation 35.30 10.10 34 310594 1801 110276870
Electrocardiogram change 35.06 10.10 30 310598 1361 110277310
Schizophrenia 35.04 10.10 9 310619 21817 110256854
Ear pain 34.74 10.10 60 310568 53166 110225505
Electrocardiogram T wave amplitude increased 34.71 10.10 12 310616 77 110278594
Generalised tonic-clonic seizure 34.46 10.10 63 310565 54617 110224054
Oxygen consumption increased 34.08 10.10 59 310569 5626 110273045
Infection susceptibility increased 33.67 10.10 51 310577 4347 110274324
Catheter placement 33.59 10.10 44 310584 3276 110275395
Endocarditis 33.56 10.10 98 310530 13273 110265398
Angina unstable 33.45 10.10 112 310516 16320 110262351
Diastolic dysfunction 33.15 10.10 93 310535 12311 110266360
Sudden cardiac death 33.14 10.10 58 310570 5579 110273092
Haemorrhage subcutaneous 32.57 10.10 57 310571 5482 110273189
Pulmonary veno-occlusive disease 32.57 10.10 35 310593 2113 110276558
Blood cholesterol 32.50 10.10 24 310604 878 110277793
Overdose 32.29 10.10 462 310166 233332 110045339
Blood pressure systolic increased 32.14 10.10 122 310506 82869 110195802
Sedation 32.07 10.10 95 310533 69588 110209083
Scrotal oedema 32.06 10.10 31 310597 1650 110277021
Asthenia 31.91 10.10 2296 308332 686703 109591968
Akathisia 31.76 10.10 5 310623 17108 110261563
Troponin T increased 31.65 10.10 49 310579 4257 110274414
Respiratory depression 31.64 10.10 26 310602 31975 110246696
Normal newborn 31.57 10.10 11 310617 21885 110256786
Eosinophilia 31.51 10.10 274 310354 57662 110221009
Left atrial dilatation 31.19 10.10 44 310584 3516 110275155
Cytomegalovirus viraemia 31.19 10.10 6 310622 17758 110260913
Dilatation ventricular 30.84 10.10 47 310581 4028 110274643
Blood test abnormal 30.71 10.10 160 310468 28394 110250277
Hypochloraemia 30.65 10.10 44 310584 3574 110275097
Blood cholesterol decreased 30.65 10.10 38 310590 2678 110275993
Cellulitis 30.63 10.10 511 310117 125505 110153166
International normalised ratio abnormal 30.58 10.10 60 310568 6297 110272374
Disability 30.58 10.10 24 310604 30199 110248472
Device alarm issue 30.50 10.10 36 310592 2410 110276261
Drug tolerance 30.43 10.10 5 310623 16580 110262091
Cardiac dysfunction 30.26 10.10 59 310569 6164 110272507
Neuroglycopenia 29.85 10.10 25 310603 1101 110277570
Rales 29.70 10.10 143 310485 24596 110254075
Hyperaldosteronism 29.56 10.10 20 310608 635 110278036
International normalised ratio decreased 29.54 10.10 69 310559 8167 110270504
Walking distance test abnormal 29.50 10.10 21 310607 725 110277946
Blood pressure abnormal 29.40 10.10 133 310495 22291 110256380
Chronic sinusitis 29.29 10.10 17 310611 25067 110253604
Lung transplant 29.29 10.10 53 310575 5233 110273438
Haemorrhoidal haemorrhage 29.25 10.10 68 310560 8025 110270646
Leukopenia 29.14 10.10 272 310356 148519 110130152
Catheter site erythema 29.12 10.10 57 310571 5971 110272700
Amnesia 29.08 10.10 175 310453 105233 110173438
Foetal death 29.08 10.10 5 310623 16040 110262631
Hypernatraemia 29.03 10.10 113 310515 17720 110260951
Platelet count normal 28.78 10.10 8 310620 21 110278650
Gouty arthritis 28.68 10.10 29 310599 1630 110277041
Peripartum cardiomyopathy 28.65 10.10 13 310615 183 110278488
Bronchopulmonary aspergillosis 28.62 10.10 25 310603 29838 110248833
Poor quality sleep 28.61 10.10 155 310473 27922 110250749
Gastric varices 28.59 10.10 22 310606 857 110277814
Altered state of consciousness 28.51 10.10 267 310361 57359 110221312
Thrombotic microangiopathy 28.43 10.10 24 310604 29125 110249546
Toxic epidermal necrolysis 28.15 10.10 263 310365 56464 110222207
Portopulmonary hypertension 28.01 10.10 12 310616 146 110278525
Protein-losing gastroenteropathy 28.00 10.10 22 310606 884 110277787
Bone marrow failure 28.00 10.10 77 310551 57771 110220900
Vascular resistance pulmonary decreased 27.94 10.10 10 310618 72 110278599
Neoplasm progression 27.66 10.10 91 310537 64504 110214167
Asterixis 27.63 10.10 39 310589 3119 110275552
Angina pectoris 27.58 10.10 282 310346 62013 110216658
Cyanosis 27.53 10.10 160 310468 29581 110249090
Oropharyngeal pain 27.49 10.10 245 310383 135031 110143640
Intra-abdominal fluid collection 27.47 10.10 43 310585 3771 110274900
Diaphragmatic spasm 27.33 10.10 11 310617 113 110278558
Proctitis 27.14 10.10 7 310621 16920 110261751
Poisoning 27.14 10.10 25 310603 29080 110249591
Abortion spontaneous 26.90 10.10 34 310594 34248 110244423
Sopor 26.90 10.10 38 310590 36508 110242163
Acidosis 26.88 10.10 130 310498 22401 110256270
Joint dislocation 26.74 10.10 34 310594 34156 110244515
Coma hepatic 26.68 10.10 23 310605 1054 110277617
Anal haemorrhage 26.62 10.10 49 310579 4903 110273768
Haemorrhagic disorder 26.54 10.10 29 310599 1784 110276887
Cardiac hypertrophy 26.53 10.10 30 310598 1917 110276754
Keratoconus 26.51 10.10 12 310616 168 110278503
Angiotensin converting enzyme inhibitor foetopathy 26.44 10.10 8 310620 31 110278640
Catheter site discharge 26.37 10.10 37 310591 2942 110275729
Right ventricular dilatation 26.30 10.10 33 310595 2354 110276317
Macular degeneration 26.27 10.10 14 310614 21645 110257026
Aspartate aminotransferase increased 26.19 10.10 611 310017 159325 110119346
Loss of personal independence in daily activities 26.15 10.10 282 310346 149738 110128933
Right ventricular dysfunction 26.10 10.10 39 310589 3284 110275387
Psychotic disorder 26.02 10.10 66 310562 50871 110227800
Fear of eating 25.95 10.10 17 310611 511 110278160
Amyloidosis 25.95 10.10 38 310590 3143 110275528
Venous pressure jugular increased 25.91 10.10 25 310603 1327 110277344
Blood potassium abnormal 25.91 10.10 43 310585 3962 110274709
Therapy partial responder 25.85 10.10 40 310588 37021 110241650
Hypotonia 25.82 10.10 100 310528 15645 110263026
Periarthritis calcarea 25.81 10.10 10 310618 92 110278579
Aspiration pleural cavity 25.80 10.10 28 310600 1709 110276962
Gastric ulcer 25.80 10.10 196 310432 39631 110239040
Pulmonary hypertensive crisis 25.65 10.10 16 310612 441 110278230
Temperature regulation disorder 25.57 10.10 3 310625 12823 110265848
Bilirubin conjugated increased 25.52 10.10 55 310573 6169 110272502
Conduction disorder 25.52 10.10 43 310585 4012 110274659
Osteonecrosis of jaw 25.48 10.10 61 310567 47956 110230715
Sedation complication 25.34 10.10 12 310616 19843 110258828
Blood creatinine abnormal 25.24 10.10 53 310575 5839 110272832
Drug resistance 25.13 10.10 78 310550 56296 110222375
Pulmonary arterial wedge pressure increased 25.12 10.10 18 310610 628 110278043
Cytomegalovirus infection reactivation 25.11 10.10 10 310618 18323 110260348
Stevens-Johnson syndrome 25.09 10.10 221 310407 46680 110231991
Injection site pruritus 24.98 10.10 68 310560 51190 110227481
Left ventricular hypertrophy 24.97 10.10 88 310540 13156 110265515
Catheter removal 24.97 10.10 18 310610 634 110278037
Ischaemic contracture of the left ventricle 24.89 10.10 11 310617 145 110278526
Peripheral swelling 24.89 10.10 906 309722 403128 109875543
Bronchiectasis 24.87 10.10 40 310588 36453 110242218
Contusion 24.74 10.10 484 310144 232877 110045794
Joint effusion 24.65 10.10 14 310614 20891 110257780
Female sexual arousal disorder 24.65 10.10 6 310622 7 110278664
Accidental exposure to product 24.62 10.10 66 310562 49942 110228729
Product administration error 24.58 10.10 184 310444 37033 110241638
COVID-19 24.56 10.10 513 310115 244547 110034124
Cerebral haemorrhage 24.56 10.10 285 310343 64683 110213988
Myasthenia gravis 24.53 10.10 15 310613 21496 110257175
Injection site swelling 24.47 10.10 90 310538 61700 110216971
Apparent mineralocorticoid excess 24.44 10.10 9 310619 71 110278600
Basal cell carcinoma 24.43 10.10 57 310571 45213 110233458
Respiratory symptom 24.31 10.10 6 310622 14939 110263732
Multiple-drug resistance 24.26 10.10 4 310624 13231 110265440
Therapeutic embolisation 24.24 10.10 17 310611 573 110278098
Feeling hot 24.22 10.10 153 310475 90953 110187718
Nephropathy 24.13 10.10 88 310540 13379 110265292
Thermohypoaesthesia 24.08 10.10 10 310618 112 110278559
Encephalopathy 24.05 10.10 340 310288 80715 110197956
Hypocalvaria 24.02 10.10 8 310620 45 110278626
White blood cell count decreased 23.94 10.10 477 310151 228913 110049758
Blood parathyroid hormone decreased 23.89 10.10 4 310624 13085 110265586
Hospitalisation 23.84 10.10 546 310082 141947 110136724
Tenosynovitis 23.79 10.10 8 310620 16275 110262396
Immune reconstitution inflammatory syndrome 23.66 10.10 8 310620 16218 110262453
Rhabdoid tumour 23.58 10.10 7 310621 25 110278646
Hypertrichosis 23.56 10.10 27 310601 1751 110276920
Bleeding varicose vein 23.53 10.10 18 310610 695 110277976
Blood glucose increased 23.52 10.10 512 310116 131984 110146687
Pericarditis constrictive 23.43 10.10 21 310607 1014 110277657
Upper respiratory tract inflammation 23.18 10.10 43 310585 4328 110274343
Gout 23.15 10.10 179 310449 36387 110242284
Pruritus 23.15 10.10 1367 309261 580193 109698478
Testicular swelling 23.14 10.10 26 310602 1650 110277021
Graft versus host disease 23.04 10.10 12 310616 18794 110259877
Porphyria acute 22.99 10.10 12 310616 18768 110259903
Musculoskeletal disorder 22.93 10.10 18 310610 22646 110256025
Calcium deficiency 22.92 10.10 22 310606 1160 110277511
Prostatomegaly 22.83 10.10 42 310586 4200 110274471
Renal artery stenosis 22.77 10.10 39 310589 3687 110274984
Colitis 22.73 10.10 181 310447 102142 110176529
Foreign body in reproductive tract 22.52 10.10 20 310608 954 110277717
Left atrial enlargement 22.46 10.10 26 310602 1705 110276966
Neutrophil count decreased 22.45 10.10 224 310404 120717 110157954
Blood pressure fluctuation 22.38 10.10 121 310507 74703 110203968
Fluid intake reduced 22.35 10.10 56 310572 6930 110271741
Left-to-right cardiac shunt 22.23 10.10 11 310617 190 110278481
Adrenal cyst 22.19 10.10 12 310616 251 110278420
Nodal arrhythmia 22.18 10.10 29 310599 2155 110276516
Decreased appetite 22.05 10.10 1586 309042 474260 109804411
Coordination abnormal 21.99 10.10 23 310605 25205 110253466
Blood sodium abnormal 21.97 10.10 23 310605 1347 110277324
Diarrhoea 21.87 10.10 3580 307048 1135925 109142746
Transplant rejection 21.86 10.10 22 310606 24545 110254126
Nephrogenic anaemia 21.78 10.10 43 310585 4534 110274137
Pneumonitis 21.67 10.10 126 310502 76405 110202266
Ectopic ACTH syndrome 21.53 10.10 11 310617 204 110278467
Primary hyperaldosteronism 21.49 10.10 12 310616 268 110278403
Aortic stenosis 21.46 10.10 83 310545 12976 110265695
Drug dose omission by device 21.44 10.10 7 310621 14509 110264162
Marasmus 21.27 10.10 25 310603 1666 110277005
Blood pressure systolic abnormal 21.27 10.10 23 310605 24827 110253844
Blood chloride decreased 21.17 10.10 65 310563 9050 110269621
Gastritis erosive 21.15 10.10 78 310550 11922 110266749
Mitral valve disease 21.13 10.10 36 310592 3389 110275282
Cough 21.10 10.10 1537 309091 460104 109818567
Occult blood positive 21.07 10.10 57 310571 7388 110271283
Abdominal pain upper 21.01 10.10 785 309843 348326 109930345
Haematotoxicity 21.00 10.10 17 310611 21065 110257606
Renal injury 20.92 10.10 106 310522 18607 110260064
Cortisol increased 20.91 10.10 16 310612 618 110278053
Blood albumin decreased 20.75 10.10 141 310487 27511 110251160
Acute myeloid leukaemia 20.55 10.10 48 310580 38062 110240609
Appendicitis 20.55 10.10 30 310598 28434 110250237
Multiple organ dysfunction syndrome 20.54 10.10 565 310063 151145 110127526
Vascular access site thrombosis 20.41 10.10 9 310619 118 110278553
Catheter site inflammation 20.21 10.10 21 310607 1219 110277452
Sputum culture 20.21 10.10 12 310616 302 110278369
Lower gastrointestinal haemorrhage 20.17 10.10 104 310524 18382 110260289
Nasal polyps 20.15 10.10 6 310622 13194 110265477
Hepatitis 20.14 10.10 159 310469 89895 110188776
Epstein-Barr virus infection 20.10 10.10 14 310614 18724 110259947
Injection site bruising 20.08 10.10 75 310553 51188 110227483
Duodenal ulcer 20.07 10.10 108 310520 19406 110259265
Vasodilatation 20.06 10.10 37 310591 3707 110274964
Radiculopathy 20.01 10.10 15 310613 19321 110259350
Upper-airway cough syndrome 20.01 10.10 93 310535 15764 110262907
Renin decreased 20.01 10.10 9 310619 124 110278547
Food allergy 19.98 10.10 16 310612 19932 110258739
BK virus infection 19.93 10.10 6 310622 13100 110265571
Muscle haemorrhage 19.85 10.10 53 310575 6816 110271855
Diabetic hyperosmolar coma 19.83 10.10 18 310610 884 110277787
Infected skin ulcer 19.76 10.10 38 310590 3929 110274742
Cardio-respiratory arrest 19.73 10.10 445 310183 115391 110163280
Colon cancer 19.70 10.10 95 310533 16348 110262323
Diffuse large B-cell lymphoma 19.69 10.10 10 310618 15888 110262783
Atrial thrombosis 19.68 10.10 40 310588 4306 110274365
Head injury 19.65 10.10 196 310432 42821 110235850
Cardiac pacemaker insertion 19.63 10.10 50 310578 6251 110272420
Cytopenia 19.61 10.10 34 310594 30082 110248589
Hydrocholecystis 19.54 10.10 15 310613 582 110278089
Acute graft versus host disease 19.40 10.10 6 310622 12875 110265796
Hyperhidrosis 19.38 10.10 390 310238 186908 110091763
Glycosylated haemoglobin increased 19.28 10.10 123 310505 23496 110255175
Faecal volume decreased 19.24 10.10 13 310615 412 110278259
ECG signs of myocardial ischaemia 19.15 10.10 13 310615 415 110278256
Malignant neoplasm progression 19.13 10.10 360 310268 174207 110104464
Gastric antral vascular ectasia 19.03 10.10 20 310608 1177 110277494
Panniculitis 19.01 10.10 10 310618 15572 110263099
Bronchial hyperreactivity 18.96 10.10 35 310593 3509 110275162
Respiratory distress 18.89 10.10 285 310343 68589 110210082
Blood pressure diastolic abnormal 18.84 10.10 27 310601 25788 110252883
Urogenital haemorrhage 18.81 10.10 18 310610 946 110277725
Toxic skin eruption 18.72 10.10 137 310491 27378 110251293
Catheter site haemorrhage 18.67 10.10 47 310581 5833 110272838
Peripheral arterial occlusive disease 18.67 10.10 63 310565 9217 110269454
Upper respiratory tract infection 18.66 10.10 258 310370 131070 110147601
Serotonin syndrome 18.62 10.10 94 310534 59059 110219612
Hepatorenal failure 18.61 10.10 21 310607 1339 110277332
Cardiac cirrhosis 18.45 10.10 11 310617 279 110278392
Blood sodium increased 18.44 10.10 45 310583 5478 110273193
Sight disability 18.29 10.10 10 310618 214 110278457
Xanthopsia 18.25 10.10 12 310616 363 110278308
Oxygen saturation increased 18.22 10.10 16 310612 752 110277919
Pulmonary artery dilatation 18.22 10.10 15 310613 645 110278026
Haemodialysis 18.17 10.10 98 310530 17621 110261050
Hidradenitis 18.15 10.10 43 310585 5137 110273534
Blood ketone body increased 18.12 10.10 17 310611 871 110277800
Vascular access site infection 18.11 10.10 9 310619 157 110278514
Acute left ventricular failure 18.07 10.10 27 310601 2274 110276397
Eosinophil count increased 18.03 10.10 111 310517 20947 110257724
Cardiac ventricular thrombosis 18.01 10.10 32 310596 3115 110275556
Electrocardiogram QRS complex abnormal 17.97 10.10 16 310612 766 110277905
Movement disorder 17.96 10.10 48 310580 36356 110242315
Right atrial dilatation 17.95 10.10 18 310610 1002 110277669
Infusion site reaction 17.94 10.10 14 310614 17668 110261003
Hypertrophic cardiomyopathy 17.89 10.10 32 310596 3131 110275540
Catheter site swelling 17.86 10.10 27 310601 2297 110276374
Splenomegaly 17.84 10.10 124 310504 24374 110254297
Erythema 17.83 10.10 654 309974 290793 109987878
Photophobia 17.80 10.10 28 310600 25743 110252928
Hypoperfusion 17.76 10.10 32 310596 3149 110275522
Tachypnoea 17.76 10.10 179 310449 39216 110239455
Platelet count decreased 17.64 10.10 804 309824 229639 110049032
Cardiac ablation 17.63 10.10 29 310599 2653 110276018
Cardiac murmur 17.55 10.10 124 310504 24504 110254167
Endometriosis male 17.50 10.10 5 310623 15 110278656
Hypocalcaemia 17.36 10.10 269 310359 65097 110213574
Dementia 17.33 10.10 150 310478 31523 110247148
Gastric varices haemorrhage 17.31 10.10 13 310615 488 110278183
Therapeutic drug monitoring analysis incorrectly performed 17.22 10.10 15 310613 697 110277974
Articular calcification 17.15 10.10 10 310618 243 110278428
Faeces discoloured 17.15 10.10 158 310470 33790 110244881
Heart sounds abnormal 17.15 10.10 21 310607 1461 110277210
Infected dermal cyst 17.07 10.10 20 310608 1328 110277343
Body mass index decreased 17.05 10.10 16 310612 820 110277851
Prescribed underdose 17.04 10.10 110 310518 65064 110213607
Premature delivery 16.99 10.10 38 310590 30594 110248077
Atrial septal defect repair 16.95 10.10 13 310615 504 110278167
Inguinal hernia 16.93 10.10 54 310574 7671 110271000
Brain oedema 16.91 10.10 39 310589 31059 110247612
Complication of device insertion 16.90 10.10 59 310569 8779 110269892
Therapeutic response increased 16.88 10.10 14 310614 608 110278063
Puncture site haemorrhage 16.87 10.10 15 310613 717 110277954
Atrioventricular block second degree 16.86 10.10 56 310572 8125 110270546
Prothrombin time ratio increased 16.84 10.10 11 310617 329 110278342
Hepatic neoplasm 16.82 10.10 35 310593 3832 110274839
Gonadotrophin deficiency 16.81 10.10 7 310621 79 110278592
Hypomania 16.80 10.10 4 310624 10206 110268465
Nephrocalcinosis 16.76 10.10 23 310605 1791 110276880
Seronegative arthritis 16.76 10.10 8 310620 13169 110265502
Senile dementia 16.72 10.10 10 310618 255 110278416
Acute on chronic liver failure 16.61 10.10 12 310616 424 110278247
Coma 16.59 10.10 232 310396 117637 110161034
Full blood count abnormal 16.58 10.10 235 310393 55817 110222854
NYHA classification 16.55 10.10 6 310622 45 110278626
Device difficult to use 16.55 10.10 17 310611 18788 110259883
Internal haemorrhage 16.54 10.10 64 310564 10007 110268664
Left ventricular enlargement 16.49 10.10 16 310612 855 110277816
Seizure 16.46 10.10 484 310144 220701 110057970
Visual impairment 16.39 10.10 272 310356 134156 110144515
Intervertebral disc degeneration 16.32 10.10 16 310612 18069 110260602
Premature labour 16.31 10.10 3 310625 9169 110269502
Influenza like illness 16.30 10.10 164 310464 88248 110190423
Sinus disorder 16.26 10.10 43 310585 32685 110245986
Left ventricular false tendon 16.22 10.10 6 310622 48 110278623
Cardiopulmonary failure 16.20 10.10 54 310574 7849 110270822
Right ventricular hypertrophy 16.19 10.10 22 310606 1697 110276974
Nocturnal dyspnoea 16.17 10.10 23 310605 1852 110276819
Vessel puncture site haemorrhage 16.16 10.10 9 310619 200 110278471
Nodule 16.12 10.10 43 310585 32588 110246083
Lethargy 16.10 10.10 360 310268 93216 110185455
Eosinophilic granulomatosis with polyangiitis 16.06 10.10 5 310623 10681 110267990
Dyskinesia 16.05 10.10 82 310546 51364 110227307
Overlap syndrome 16.03 10.10 3 310625 9056 110269615
Tricuspid valve replacement 16.02 10.10 5 310623 22 110278649
Red cell distribution width abnormal 16.02 10.10 10 310618 276 110278395
Blood pressure orthostatic 16.00 10.10 7 310621 90 110278581
Death 15.99 10.10 2218 308410 696651 109582020
Monocytosis 15.98 10.10 22 310606 1718 110276953
Hormone-dependent prostate cancer 15.96 10.10 9 310619 205 110278466
Ventricular dyssynchrony 15.93 10.10 7 310621 91 110278580
Hypoparathyroidism secondary 15.92 10.10 10 310618 279 110278392
Paradoxical drug reaction 15.85 10.10 4 310624 9813 110268858
Urine potassium increased 15.84 10.10 5 310623 23 110278648
Dilatation atrial 15.75 10.10 34 310594 3818 110274853
Glucose tolerance impaired 15.74 10.10 62 310566 9775 110268896
Pericardial calcification 15.70 10.10 6 310622 53 110278618
Posterior reversible encephalopathy syndrome 15.70 10.10 46 310582 33815 110244856
Stupor 15.66 10.10 55 310573 8210 110270461
Activated partial thromboplastin time shortened 15.63 10.10 17 310611 1040 110277631
Tricuspid valve disease 15.63 10.10 12 310616 466 110278205
Tendonitis 15.60 10.10 31 310597 26052 110252619
Heart transplant 15.59 10.10 21 310607 1607 110277064
Right ventricular systolic pressure increased 15.48 10.10 17 310611 1052 110277619
Preternatural anus 15.46 10.10 7 310621 98 110278573
Aggression 15.45 10.10 100 310528 59110 110219561
Chronic respiratory failure 15.45 10.10 34 310594 3869 110274802
Scrotal swelling 15.39 10.10 18 310610 1193 110277478
Bundle branch block 15.38 10.10 22 310606 1781 110276890
Electrocardiogram QT prolonged 15.37 10.10 408 310220 108552 110170119
Pulmonary vein stenosis 15.34 10.10 8 310620 155 110278516
Quadriparesis 15.34 10.10 38 310590 4669 110274002
Portal shunt procedure 15.34 10.10 5 310623 26 110278645
Symblepharon 15.32 10.10 12 310616 480 110278191
Prothrombin level decreased 15.31 10.10 22 310606 1788 110276883
Renal tubular acidosis 15.30 10.10 38 310590 4677 110273994
Hypoglycaemic coma 15.30 10.10 42 310586 5491 110273180
Procedural pain 15.30 10.10 50 310578 35515 110243156
Forced expiratory volume decreased 15.29 10.10 9 310619 13167 110265504
Haemothorax 15.28 10.10 49 310579 6982 110271689
Haemophagocytic lymphohistiocytosis 15.28 10.10 42 310586 31517 110247154
Hypoxia 15.25 10.10 474 310154 129041 110149630
Catastrophic reaction 15.18 10.10 5 310623 27 110278644
Hypochromic anaemia 15.14 10.10 30 310598 3171 110275500
Diet noncompliance 15.13 10.10 13 310615 593 110278078
Muscle spasms 15.10 10.10 633 309995 277524 110001147
Defect conduction intraventricular 15.09 10.10 14 310614 707 110277964
Bladder irrigation 15.05 10.10 6 310622 60 110278611
Glaucoma 15.05 10.10 25 310603 22492 110256179
Subcutaneous haematoma 15.02 10.10 29 310599 3007 110275664
Catheter site pain 15.00 10.10 46 310582 6400 110272271
Gender dysphoria 14.96 10.10 6 310622 61 110278610
Haemoglobin increased 14.92 10.10 58 310570 9089 110269582
Rash pruritic 14.90 10.10 190 310438 97879 110180792
Leukaemic infiltration renal 14.89 10.10 5 310623 29 110278642
Dermatitis contact 14.88 10.10 78 310550 13875 110264796
Device inappropriate shock delivery 14.87 10.10 6 310622 62 110278609
Hypertensive heart disease 14.87 10.10 37 310591 4559 110274112
Aspergillus infection 14.85 10.10 31 310597 25585 110253086
Right-to-left cardiac shunt 14.85 10.10 10 310618 315 110278356
Venous oxygen saturation decreased 14.71 10.10 6 310622 64 110278607
Oesophageal carcinoma 14.65 10.10 7 310621 11517 110267154
Cystitis haemorrhagic 14.65 10.10 8 310620 12201 110266470
Metastases to central nervous system 14.64 10.10 26 310602 22791 110255880
Myasthenic syndrome 14.63 10.10 18 310610 1258 110277413
Secondary sexual characteristics absence 14.63 10.10 3 310625 0 110278671
Immune effector cell-associated neurotoxicity syndrome 14.63 10.10 12 310616 14770 110263901
Exposure to toxic agent 14.61 10.10 9 310619 12849 110265822
Neurologic neglect syndrome 14.61 10.10 4 310624 9294 110269377
Uveitis 14.60 10.10 24 310604 21686 110256985
Adjustment disorder 14.60 10.10 6 310622 10789 110267882
Cardiac function test abnormal 14.60 10.10 8 310620 172 110278499
Haematocrit abnormal 14.57 10.10 21 310607 1712 110276959
Neurotoxicity 14.49 10.10 65 310563 42142 110236529
Synovial cyst 14.44 10.10 7 310621 11423 110267248
Activated partial thromboplastin time prolonged 14.44 10.10 110 310518 22258 110256413
Myocardial ischaemia 14.41 10.10 126 310502 26558 110252113
Mouth ulceration 14.31 10.10 78 310550 48060 110230611
Diffuse vasculitis 14.30 10.10 7 310621 118 110278553
Urine output increased 14.26 10.10 27 310601 2759 110275912
Device occlusion 14.25 10.10 82 310546 15103 110263568
Respiratory tract congestion 14.25 10.10 42 310586 30815 110247856
Scrotal infection 14.16 10.10 14 310614 766 110277905
Multiple sclerosis 14.15 10.10 32 310596 25666 110253005
Hepatotoxicity 14.15 10.10 112 310516 63288 110215383
Vascular device infection 14.11 10.10 87 310541 16425 110262246
Affect lability 14.09 10.10 19 310609 18618 110260053
Second primary malignancy 14.09 10.10 18 310610 18050 110260621
Haemorrhage 14.06 10.10 396 310232 106296 110172375
Prothrombin level increased 14.05 10.10 12 310616 543 110278128
Subchorionic haematoma 14.04 10.10 7 310621 123 110278548
QRS axis abnormal 14 10.10 25 310603 2443 110276228
Right atrial pressure increased 13.93 10.10 10 310618 350 110278321
Euglycaemic diabetic ketoacidosis 13.82 10.10 67 310561 11556 110267115
Hydrothorax 13.80 10.10 20 310608 1638 110277033
Hepatic calcification 13.80 10.10 10 310618 355 110278316
Infusion site pain 13.78 10.10 90 310538 17329 110261342
Extrasystoles 13.78 10.10 53 310575 8265 110270406
Labelled drug-disease interaction medication error 13.78 10.10 10 310618 356 110278315
Throat tightness 13.78 10.10 48 310580 33441 110245230
Stasis dermatitis 13.77 10.10 21 310607 1801 110276870
Mesenteric vein thrombosis 13.69 10.10 22 310606 1973 110276698
Blood culture negative 13.64 10.10 9 310619 274 110278397
Scleroderma 13.61 10.10 44 310584 6297 110272374
Neutropenic colitis 13.59 10.10 3 310625 8062 110270609
Chronic right ventricular failure 13.58 10.10 6 310622 79 110278592
Collateral circulation 13.58 10.10 6 310622 79 110278592
Walking disability 13.57 10.10 25 310603 2503 110276168
Bile acid malabsorption 13.56 10.10 11 310617 463 110278208
General symptom 13.54 10.10 4 310624 8842 110269829
Blood catecholamines decreased 13.53 10.10 4 310624 14 110278657
Coagulopathy 13.53 10.10 175 310453 40736 110237935
Thromboembolectomy 13.50 10.10 7 310621 134 110278537
Craniocerebral injury 13.49 10.10 42 310586 5892 110272779
Blood chloride increased 13.48 10.10 44 310584 6328 110272343
Dysuria 13.46 10.10 241 310387 59990 110218681
Cardiac pacemaker evaluation 13.45 10.10 7 310621 135 110278536
Drug withdrawal syndrome 13.43 10.10 58 310570 37996 110240675
Intracardiac thrombus 13.43 10.10 34 310594 4234 110274437
Nephrolithiasis 13.41 10.10 120 310508 66092 110212579
Fatigue 13.40 10.10 3119 307509 1212839 109065832
Peptic ulcer perforation 13.39 10.10 14 310614 819 110277852
Accelerated idioventricular rhythm 13.38 10.10 9 310619 283 110278388
Medication error 13.24 10.10 212 310416 105154 110173517
Alkalosis hypochloraemic 13.22 10.10 12 310616 589 110278082
Multiple drug therapy 13.22 10.10 51 310577 7963 110270708
Optic nerve operation 13.16 10.10 11 310617 483 110278188
Gastrointestinal vascular malformation haemorrhagic 13.16 10.10 15 310613 967 110277704
Demyelination 13.15 10.10 5 310623 9424 110269247
Bladder cancer 13.13 10.10 23 310605 20269 110258402
Bradypnoea 13.08 10.10 4 310624 8645 110270026
Immature granulocyte count increased 13.06 10.10 14 310614 843 110277828
Secretion discharge 13.05 10.10 23 310605 20221 110258450
Coronary artery bypass 13.03 10.10 42 310586 6000 110272671
Supraventricular extrasystoles 13.01 10.10 51 310577 8022 110270649
Metastases to nervous system 13.00 10.10 9 310619 297 110278374
Amaurosis 12.99 10.10 19 310609 1570 110277101
Alpha 1 foetoprotein increased 12.96 10.10 14 310614 850 110277821
Primary biliary cholangitis 12.93 10.10 18 310610 1421 110277250
Mass 12.93 10.10 22 310606 19608 110259063
Base excess decreased 12.90 10.10 10 310618 394 110278277
Wrong technique in product usage process 12.88 10.10 329 310299 87019 110191652
Cardiac failure high output 12.86 10.10 11 310617 499 110278172
Haemodynamic instability 12.84 10.10 109 310519 22779 110255892
Osteoporosis 12.82 10.10 170 310458 86982 110191689
Percussion test abnormal 12.81 10.10 5 310623 47 110278624
Postrenal failure 12.80 10.10 14 310614 862 110277809
Kidney transplant rejection 12.80 10.10 9 310619 11978 110266693
Gastritis 12.77 10.10 217 310411 53482 110225189
Cerebral artery embolism 12.77 10.10 22 310606 2090 110276581
Dystonia 12.75 10.10 34 310594 25771 110252900
Arterial stenosis 12.72 10.10 19 310609 1600 110277071
Prolactin-producing pituitary tumour 12.67 10.10 7 310621 153 110278518
Electrolyte depletion 12.67 10.10 11 310617 509 110278162
Inappropriate schedule of product administration 12.67 10.10 456 310172 203181 110075490
Steroid dependence 12.66 10.10 4 310624 8465 110270206
Haemorrhagic stroke 12.64 10.10 74 310554 13715 110264956
Subcutaneous drug absorption impaired 12.60 10.10 3 310625 7656 110271015
Hypomagnesaemia 12.60 10.10 239 310389 60131 110218540
Affective disorder 12.59 10.10 8 310620 11233 110267438
Blood pressure increased 12.58 10.10 595 310033 257778 110020893
Drug specific antibody present 12.58 10.10 4 310624 8430 110270241
Persistent foetal circulation 12.56 10.10 3 310625 3 110278668
Bronchopulmonary aspergillosis allergic 12.56 10.10 4 310624 8422 110270249
Child-Pugh-Turcotte score increased 12.54 10.10 5 310623 50 110278621
Spinal fusion surgery 12.53 10.10 5 310623 9151 110269520
Oxygen consumption decreased 12.53 10.10 11 310617 517 110278154
Encephalitis 12.51 10.10 21 310607 18818 110259853
Blood bilirubin unconjugated increased 12.49 10.10 16 310612 1165 110277506
Arteriovenous fistula 12.49 10.10 18 310610 1467 110277204
Injection site mass 12.49 10.10 32 310596 24581 110254090
Pulmonary capillary haemangiomatosis 12.48 10.10 6 310622 97 110278574
Substance abuse 12.48 10.10 10 310618 12453 110266218
Rhinitis 12.48 10.10 28 310600 22517 110256154
Headache 12.47 10.10 2235 308393 880142 109398529
Therapeutic response shortened 12.44 10.10 42 310586 29541 110249130
Gastroenteritis 12.42 10.10 165 310463 38635 110240036
Apheresis related complication 12.40 10.10 4 310624 20 110278651
Liver carcinoma ruptured 12.39 10.10 9 310619 321 110278350
Ventricular assist device insertion 12.37 10.10 5 310623 52 110278619
Macroangiopathy 12.35 10.10 7 310621 161 110278510
Dermatitis bullous 12.34 10.10 88 310540 17441 110261230
Duodenal ulcer haemorrhage 12.34 10.10 50 310578 7987 110270684
Brain stem stroke 12.33 10.10 13 310615 768 110277903
Atrial pressure increased 12.32 10.10 6 310622 100 110278571
Haematoma muscle 12.27 10.10 32 310596 4058 110274613
Withdrawal syndrome 12.23 10.10 46 310582 31334 110247337
Paranoia 12.21 10.10 28 310600 22346 110256325
Diabetic nephropathy 12.16 10.10 29 310599 3479 110275192
Hepatitis fulminant 12.16 10.10 52 310576 8508 110270163
Gamma-glutamyltransferase abnormal 12.15 10.10 14 310614 913 110277758
Breast pain 12.15 10.10 58 310570 9942 110268729
Brain natriuretic peptide 12.12 10.10 5 310623 55 110278616
Graft versus host disease in gastrointestinal tract 12.11 10.10 5 310623 8963 110269708
Ventricular failure 12.09 10.10 11 310617 542 110278129
Adenovirus infection 12.08 10.10 8 310620 10986 110267685
Hypertrophy 12.06 10.10 14 310614 921 110277750
Fractured sacrum 12.04 10.10 21 310607 2015 110276656
Blood phosphorus increased 12.01 10.10 17 310611 16323 110262348
Hepatic hydrothorax 12.00 10.10 6 310622 106 110278565
Supraventricular tachycardia 12.00 10.10 113 310515 24309 110254362
Personality disorder 12.00 10.10 11 310617 12826 110265845
Gingival pain 11.94 10.10 16 310612 15720 110262951
Catheter site scab 11.91 10.10 8 310620 251 110278420
Injection site haemorrhage 11.87 10.10 50 310578 32978 110245693
Costal cartilage fracture 11.85 10.10 8 310620 253 110278418
Malnutrition 11.84 10.10 123 310505 27156 110251515
Resting tremor 11.82 10.10 19 310609 1704 110276967
Ataxia 11.82 10.10 44 310584 30064 110248607
Urethral injury 11.81 10.10 5 310623 59 110278612
Cerebral haematoma 11.80 10.10 56 310572 9576 110269095
Insurance issue 11.78 10.10 60 310568 10552 110268119
Gait disturbance 11.76 10.10 650 309978 277558 110001113
Alcoholic liver disease 11.75 10.10 11 310617 562 110278109
Neurological symptom 11.71 10.10 16 310612 15592 110263079
Deformity 11.70 10.10 7 310621 10153 110268518
Emotional disorder 11.70 10.10 17 310611 16143 110262528
Acquired haemophilia 11.66 10.10 24 310604 2607 110276064
Blood albumin abnormal 11.53 10.10 13 310615 828 110277843
CSF protein abnormal 11.53 10.10 4 310624 26 110278645
Inferior vena cava syndrome 11.52 10.10 6 310622 116 110278555
Blood electrolytes abnormal 11.51 10.10 21 310607 2087 110276584
Infusion site erythema 11.50 10.10 65 310563 11894 110266777
Blood thyroid stimulating hormone abnormal 11.48 10.10 15 310613 1114 110277557
Paraesthesia oral 11.48 10.10 52 310576 33619 110245052
Central venous catheterisation 11.47 10.10 30 310598 3812 110274859
Pathogen resistance 11.46 10.10 20 310608 17652 110261019
Cardiac operation 11.45 10.10 40 310588 5955 110272716
Tremor 11.44 10.10 458 310170 201774 110076897
Catheter site abscess 11.40 10.10 8 310620 270 110278401
Type 3 diabetes mellitus 11.38 10.10 6 310622 119 110278552
Cryoglobulins present 11.35 10.10 3 310625 6 110278665
Portal vein pressure increased 11.35 10.10 3 310625 6 110278665
Intestinal varices haemorrhage 11.35 10.10 3 310625 6 110278665
CREST syndrome 11.35 10.10 10 310618 472 110278199
Cardiac asthma 11.32 10.10 8 310620 273 110278398
Choking 11.31 10.10 77 310551 15033 110263638
Anorectal varices 11.31 10.10 5 310623 66 110278605
Breast cancer female 11.28 10.10 11 310617 12457 110266214
Pulmonary arteriovenous fistula 11.27 10.10 4 310624 28 110278643
Infective pulmonary exacerbation of cystic fibrosis 11.23 10.10 15 310613 14756 110263915
Labelled drug-drug interaction issue 11.21 10.10 31 310597 4070 110274601
Perineal infection 11.21 10.10 13 310615 854 110277817
Pustular psoriasis 11.20 10.10 13 310615 13592 110265079
Adrenomegaly 11.19 10.10 10 310618 481 110278190
Osteopenia 11.17 10.10 29 310599 22180 110256491
Muscular weakness 11.16 10.10 577 310051 247891 110030780
Hyperphosphataemia 11.12 10.10 18 310610 16363 110262308
Coagulation factor increased 11.11 10.10 5 310623 69 110278602
Craniotomy 11.11 10.10 11 310617 603 110278068
Immobilisation syndrome 11.10 10.10 13 310615 863 110277808
Mycobacterium ulcerans infection 11.07 10.10 6 310622 126 110278545
Initial insomnia 11.02 10.10 58 310570 10331 110268340
Rash vesicular 11.02 10.10 15 310613 14637 110264034
Injection site warmth 11.01 10.10 20 310608 17385 110261286
Drug monitoring procedure not performed 11.01 10.10 16 310612 1314 110277357
Troponin increased 10.99 10.10 130 310498 29636 110249035
Osteonecrosis 10.97 10.10 53 310575 33688 110244983
Burns second degree 10.95 10.10 4 310624 7729 110270942
Eye pain 10.95 10.10 89 310539 50010 110228661
Haemorrhagic infarction 10.95 10.10 13 310615 876 110277795
Congenital arterial malformation 10.92 10.10 4 310624 31 110278640
Blood antidiuretic hormone increased 10.92 10.10 5 310623 72 110278599
Time perception altered 10.91 10.10 7 310621 203 110278468
Simple partial seizures 10.90 10.10 14 310614 1022 110277649
Diverticulitis intestinal haemorrhagic 10.86 10.10 10 310618 500 110278171
Septic shock 10.86 10.10 544 310084 156984 110121687
Catheter site rash 10.86 10.10 14 310614 1026 110277645
Rhinorrhoea 10.85 10.10 213 310415 102453 110176218
Intracranial aneurysm 10.84 10.10 35 310593 5005 110273666
Cutaneous vasculitis 10.83 10.10 67 310561 12662 110266009
Herpes zoster 10.82 10.10 227 310401 108152 110170519
Electrocardiogram P wave abnormal 10.81 10.10 9 310619 393 110278278
Pulmonary vascular resistance abnormality 10.79 10.10 7 310621 207 110278464
Tuberculosis 10.74 10.10 21 310607 17753 110260918
Body temperature increased 10.71 10.10 100 310528 54613 110224058
Glucose tolerance decreased 10.68 10.10 5 310623 76 110278595
Heart valve incompetence 10.66 10.10 30 310598 3979 110274692
Staphylococcus test positive 10.64 10.10 45 310583 7325 110271346
Nasal oedema 10.64 10.10 3 310625 6836 110271835
Traumatic haematoma 10.63 10.10 22 310606 2399 110276272
Hypocoagulable state 10.60 10.10 23 310605 2592 110276079
Blood corticotrophin increased 10.59 10.10 8 310620 303 110278368
Splinter haemorrhages 10.59 10.10 6 310622 138 110278533
Hyperglycaemic hyperosmolar nonketotic syndrome 10.57 10.10 25 310603 2984 110275687
Carotid artery occlusion 10.57 10.10 54 310574 9511 110269160
Coronary artery disease 10.56 10.10 270 310358 71420 110207251
Idiopathic angioedema 10.56 10.10 5 310623 78 110278593
Drug monitoring procedure incorrectly performed 10.56 10.10 12 310616 771 110277900
Diabetes mellitus inadequate control 10.54 10.10 129 310499 29646 110249025
Caesarean section 10.54 10.10 14 310614 13803 110264868
Rhythm idioventricular 10.54 10.10 12 310616 773 110277898
Pancreatitis chronic 10.52 10.10 32 310596 4433 110274238
Oral lichen planus 10.51 10.10 13 310615 914 110277757
Cryptogenic cirrhosis 10.50 10.10 5 310623 79 110278592
Univentricular heart 10.50 10.10 3 310625 9 110278662
Pancreatic enzymes decreased 10.50 10.10 3 310625 9 110278662
Blood bicarbonate decreased 10.49 10.10 38 310590 5759 110272912
Hypoosmolar state 10.49 10.10 9 310619 410 110278261
Gastric ulcer haemorrhage 10.47 10.10 56 310572 10038 110268633
Product storage error 10.45 10.10 29 310599 21699 110256972
Heart disease congenital 10.41 10.10 11 310617 651 110278020
Bulbospinal muscular atrophy congenital 10.40 10.10 4 310624 36 110278635
Prurigo 10.39 10.10 16 310612 1384 110277287
Volume blood decreased 10.38 10.10 9 310619 416 110278255
Hypoaesthesia oral 10.35 10.10 20 310608 16982 110261689
Prostate cancer metastatic 10.34 10.10 34 310594 4909 110273762
Immunoglobulins increased 10.33 10.10 12 310616 790 110277881
Diabetic neuropathy 10.31 10.10 43 310585 6956 110271715
Venous pressure increased 10.31 10.10 4 310624 37 110278634
Hypercapnia 10.31 10.10 60 310568 11099 110267572
Malignant ascites 10.30 10.10 16 310612 1394 110277277
Haemoconcentration 10.30 10.10 7 310621 224 110278447
Drug level decreased 10.29 10.10 23 310605 18525 110260146
Tachycardia induced cardiomyopathy 10.27 10.10 7 310621 225 110278446
Fractured coccyx 10.22 10.10 15 310613 1243 110277428
Pulmonary valve incompetence 10.18 10.10 23 310605 2663 110276008
Listeraemia 10.18 10.10 5 310623 85 110278586
Hypergammaglobulinaemia 10.17 10.10 13 310615 945 110277726
Cardiovascular insufficiency 10.15 10.10 26 310602 3262 110275409
Vasoplegia syndrome 10.14 10.10 36 310592 5403 110273268
Duplicate therapy error 10.12 10.10 9 310619 430 110278241
Fat intolerance 10.12 10.10 4 310624 39 110278632

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypocalvaria 36.09 24.96 9 136 40 113768
Generalised tonic-clonic seizure 30.18 24.96 10 135 139 113669

Pharmacologic Action:

SourceCodeDescription
ATC C03DA01 CARDIOVASCULAR SYSTEM
DIURETICS
ALDOSTERONE ANTAGONISTS AND OTHER POTASSIUM-SPARING AGENTS
Aldosterone antagonists
FDA MoA N0000011310 Aldosterone Antagonists
FDA EPC N0000175557 Aldosterone Antagonist
MeSH PA D000451 Mineralocorticoid Receptor Antagonists
MeSH PA D004232 Diuretics
MeSH PA D006727 Hormone Antagonists
MeSH PA D045283 Natriuretic Agents
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35498 diuretic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:38070 anti-arrhythmia drug
CHEBI has role CHEBI:50844 aldosterone antagonist
CHEBI has role CHEBI:62868 hepatoprotective agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:78298 environmental contaminant
CHEBI has role CHEBI:231911 renoprotective agent
CHEBI has role CHEBI:233423 antifibrotic agent

Related Drugs by ATC class:

C03DA Aldosterone antagonists 5 drugs
canrenonedapagliflozineplerenonefinerenonepotassium canrenoate

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Chronic heart failure indication 48447003
Aldosteronism indication 88213004 DOID:446
Edema indication 267038008
Ascites indication 389026000
Diagnostic Test for Primary Aldosteronism indication
Hypokalemia Prevention indication
Peripheral Edema due to Chronic Heart Failure indication
Edema due to Hepatic Cirrhosis indication
Edema due to Nephrotic Syndrome indication
Pulmonary Edema due to Chronic Heart Failure indication
Acne off-label use 11381005 DOID:6543
Polycystic ovaries off-label use 69878008
Anuria contraindication 2472002 DOID:2983
Hypercholesterolemia contraindication 13644009
Hyperkalemia contraindication 14140009
Metabolic acidosis, normal anion gap, acidifying salts contraindication 18104000
Secondary angle-closure glaucoma contraindication 21571006
Hypovolemia contraindication 28560003
Dehydration contraindication 34095006
Hyperuricemia contraindication 35885006 DOID:1920
Hypokalemia contraindication 43339004
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Acute nephropathy contraindication 58574008
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Hypomagnesemia contraindication 190855004
Acute pancreatitis contraindication 197456007 DOID:2913
Neonatal hyperbilirubinemia contraindication 281610001
Azotemia contraindication 445009001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

ProductApplicantIngredients
Cardalis Ceva Sante Animale 2

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
25MG/5ML CAROSPIR CMP DEV LLC N209478 Aug. 4, 2017 RX SUSPENSION ORAL 11395828 Oct. 28, 2036 CAROSPIR IS INDICATED AS AN ADD-ON THERAPY FOR THE TREATMENT OF HYPERTENSION, TO LOWER BLOOD PRESSURE IN ADULT PATIENTS WHO ARE NOT ADEQUATELY CONTROLLED ON OTHER AGENTS
25MG/5ML CAROSPIR CMP DEV LLC N209478 Aug. 4, 2017 RX SUSPENSION ORAL 11395828 Oct. 28, 2036 CAROSPIR IS INDICATED FOR THE MANAGEMENT OF EDEMA IN ADULT CIRRHOTIC PATIENTS WHEN EDEMA IS NOT RESPONSIVE TO FLUID AND SODIUM RESTRICTION
25MG/5ML CAROSPIR CMP DEV LLC N209478 Aug. 4, 2017 RX SUSPENSION ORAL 11395828 Oct. 28, 2036 CAROSPIR IS INDICATED FOR TREATMENT OF NYHA CLASS III-IV HEART FAILURE AND REDUCED EJECTION FRACTION TO INCREASE SURVIVAL, MANAGE EDEMA, AND TO REDUCE THE NEED FOR HOSPITALIZATION FOR HEART FAILURE
25MG/5ML CAROSPIR CMP DEV LLC N209478 Aug. 4, 2017 RX SUSPENSION ORAL 9757394 Oct. 28, 2036 CAROSPIR IS INDICATED FOR TREATMENT OF NYHA CLASS III-IV HEART FAILURE AND REDUCED EJECTION FRACTION TO INCREASE SURVIVAL, MANAGE EDEMA, AND TO REDUCE THE NEED FOR HOSPITALIZATION FOR HEART FAILURE

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Mineralocorticoid receptor Nuclear hormone receptor ANTAGONIST IC50 9.88 WOMBAT-PK CHEMBL
Nuclear receptor subfamily 1 group I member 2 Nuclear hormone receptor WOMBAT-PK
Androgen receptor Nuclear hormone receptor Ki 7.40 CHEMBL
Progesterone receptor Nuclear hormone receptor EC50 6.03 WOMBAT-PK
Estrogen receptor beta Nuclear hormone receptor EC50 5.48 CHEMBL
Cytochrome P450 2C19 Enzyme IC50 5.52 DRUG MATRIX
Glucocorticoid receptor Nuclear hormone receptor IC50 6.23 WOMBAT-PK
Multidrug and toxin extrusion protein 1 Transporter IC50 4.73 CHEMBL
Androgen receptor Transcription factor IC50 6.17 CHEMBL
Progesterone receptor Transcription factor Ki 6.66 DRUG MATRIX

External reference:

IDSource
4017881 VUID
N0000146234 NUI
D00443 KEGG_DRUG
4017881 VANDF
C0037982 UMLSCUI
CHEBI:9241 CHEBI
SNL PDB_CHEM_ID
CHEMBL1393 ChEMBL_ID
D013148 MESH_DESCRIPTOR_UI
DB00421 DRUGBANK_ID
5833 PUBCHEM_CID
2875 IUPHAR_LIGAND_ID
987 INN_ID
27O7W4T232 UNII
151317 RXNORM
1558 MMSL
1587 MMSL
5506 MMSL
d00373 MMSL
002211 NDDF
13929005 SNOMEDCT_US
387078006 SNOMEDCT_US
27O7W4T232 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Aldactone HUMAN PRESCRIPTION DRUG LABEL 1 0025-1001 TABLET, FILM COATED 25 mg ORAL NDA 28 sections
Aldactone HUMAN PRESCRIPTION DRUG LABEL 1 0025-1031 TABLET, FILM COATED 100 mg ORAL NDA 28 sections
Aldactone HUMAN PRESCRIPTION DRUG LABEL 1 0025-1041 TABLET, FILM COATED 50 mg ORAL NDA 28 sections
Spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 0378-0243 TABLET, FILM COATED 50 mg ORAL ANDA 26 sections
Spironolactone and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0403 TABLET 25 mg ORAL ANDA 25 sections
Spironolactone and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0403 TABLET 25 mg ORAL ANDA 25 sections
Spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 0378-0437 TABLET, FILM COATED 100 mg ORAL ANDA 26 sections
Spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 0378-2146 TABLET, FILM COATED 25 mg ORAL ANDA 26 sections
SPIRONOLACTONE HUMAN PRESCRIPTION DRUG LABEL 1 0574-1133 SUSPENSION 25 mg ORAL NDA authorized generic 25 sections
SPIRONOLACTONE HUMAN PRESCRIPTION DRUG LABEL 1 0615-8451 TABLET 25 mg ORAL ANDA 25 sections
SPIRONOLACTONE HUMAN PRESCRIPTION DRUG LABEL 1 0615-8452 TABLET 50 mg ORAL ANDA 25 sections
spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 0904-6927 TABLET, FILM COATED 25 mg ORAL ANDA 24 sections
Spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 10544-499 TABLET 25 mg ORAL ANDA 16 sections
Spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 10544-523 TABLET 25 mg ORAL ANDA 16 sections
Spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 16729-225 TABLET, FILM COATED 25 mg ORAL ANDA 26 sections
Spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 16729-226 TABLET, FILM COATED 50 mg ORAL ANDA 26 sections
Spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 16729-227 TABLET, FILM COATED 100 mg ORAL ANDA 26 sections
CaroSpir HUMAN PRESCRIPTION DRUG LABEL 1 17856-0120 Suspension 25 mg ORAL NDA 25 sections
SPIRONOLACTONE HUMAN PRESCRIPTION DRUG LABEL 1 17856-1133 SUSPENSION 25 mg ORAL NDA authorized generic 25 sections
Spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 17856-2028 SUSPENSION 25 mg ORAL ANDA 27 sections
Spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 21695-766 TABLET 25 mg ORAL ANDA 26 sections
Spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 21695-960 TABLET, FILM COATED 50 mg ORAL ANDA 26 sections
spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 31722-094 TABLET, FILM COATED 25 mg ORAL ANDA 25 sections
spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 31722-095 TABLET, FILM COATED 50 mg ORAL ANDA 25 sections
spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 31722-096 TABLET, FILM COATED 100 mg ORAL ANDA 25 sections
spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 31722-691 SUSPENSION 25 mg ORAL ANDA 25 sections
Spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 33261-764 TABLET, FILM COATED 100 mg ORAL ANDA 27 sections
Spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 33261-869 TABLET, FILM COATED 25 mg ORAL ANDA 27 sections
Spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 33261-895 TABLET, FILM COATED 50 mg ORAL ANDA 27 sections
Spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 42254-183 TABLET, FILM COATED 25 mg ORAL ANDA 26 sections