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2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
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L1000
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
spiperone 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
tranquillizers, neuroleptics, 4'-fluoro-4-piperidinobutyrophenone derivatives
2470
749-02-0
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
spiperone
spiroperidol
spiroperidone
spiropitan
A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
Molecular weight: 395.48
Formula: C23H26FN3O2
CLOGP: 3
LIPINSKI: 0
HAC: 5
HDO: 1
TPSA: 52.65
ALOGS: -3.38
ROTB: 6
Drug dosage:
None
ADMET properties:
None
Approvals:
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Date
Agency
Company
Orphan
Jan. 1, 1969
YEAR INTRODUCED
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
CHEBI has role
CHEBI:35471
psychotropic drugs
CHEBI has role
CHEBI:35476
neuroleptics
CHEBI has role
CHEBI:37890
alpha-adrenergic receptor blockaders
CHEBI has role
CHEBI:48279
serotonin antagonists
CHEBI has role
CHEBI:48561
dopaminergic antagonists
MeSH PA
D014150
Antipsychotic Agents
MeSH PA
D002491
Central Nervous System Agents
MeSH PA
D002492
Central Nervous System Depressants
MeSH PA
D015259
Dopamine Agents
MeSH PA
D018492
Dopamine Antagonists
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Schizophrenia
indication
58214004
DOID:5419
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
13.57
acidic
pKa2
8.15
Basic
pKa3
5.3
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
5-hydroxytryptamine receptor 2A
GPCR
P28223
5HT2A_HUMAN
ANTAGONIST
Ki
8.65
CHEMBL
KEGG DRUG
D(2) dopamine receptor
GPCR
P14416
DRD2_HUMAN
ANTAGONIST
Ki
10.22
CHEMBL
KEGG DRUG
5-hydroxytryptamine receptor 1A
GPCR
P08908
5HT1A_HUMAN
Kd
7.40
CHEMBL
5-hydroxytryptamine receptor 2B
GPCR
P41595
5HT2B_HUMAN
ANTAGONIST
Ki
6.50
IUPHAR
5-hydroxytryptamine receptor 2C
GPCR
P28335
5HT2C_HUMAN
Ki
5.94
CHEMBL
5-hydroxytryptamine receptor 6
GPCR
P50406
5HT6R_HUMAN
Ki
5.80
CHEMBL
5-hydroxytryptamine receptor 7
GPCR
P34969
5HT7R_HUMAN
Ki
6.96
CHEMBL
Alpha-1A adrenergic receptor
GPCR
P35348
ADA1A_HUMAN
Ki
8.10
CHEMBL
D(3) dopamine receptor
GPCR
P35462
DRD3_HUMAN
Ki
9.92
CHEMBL
D(1B) dopamine receptor
GPCR
P21918
DRD5_HUMAN
ANTAGONIST
Ki
5.30
IUPHAR
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External reference:
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ID
Source
SIP
PDB_CHEM_ID
1553
INN_ID
4X6E73CJ0Q
UNII
5265
PUBCHEM_CID
77222007
SNOMEDCT_US
99
IUPHAR_LIGAND_ID
C0037956
UMLSCUI
CHEBI:9233
CHEBI
CHEMBL267930
ChEMBL_ID
D01051
KEGG_DRUG
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Pharmaceutical products:
None
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spiperone