spectinomycin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, produced by Streptomyces strains 2468 1695-77-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • spectinomycin hydrochloride
  • spectinomycin
  • actinospectacin
  • espectinomicina
  • spectacin
  • spectam
  • togamycin
  • trobicin
  • spectinomycin dihydrochloride
  • spectinomycin HCl
An antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of GONORRHEA.
  • Molecular weight: 332.35
  • Formula: C14H24N2O7
  • CLOGP: -2.88
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 5
  • TPSA: 129.51
  • ALOGS: -0.35
  • ROTB: 2

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
3 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 7.50 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 70 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 200.69 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.13 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.99 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.80 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
June 30, 1971 FDA PFIZER

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01XX04 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER ANTIBACTERIALS
Other antibacterials
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Gonorrhea indication 15628003 DOID:7551
Acute gonococcal cervicitis indication 20943002 DOID:10615
Acute gonococcal urethritis indication 29864006
Gonorrhea of rectum indication 42746002
Disseminated Gonococcal Infection indication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.28 acidic
pKa2 9.94 Basic
pKa3 5.96 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
30S ribosomal protein S12 Cytosolic other WOMBAT-PK

External reference:

IDSource
D000198 MESH_DESCRIPTOR_UI
4018092 VUID
N0000179731 NUI
C0887525 UMLSCUI
D08526 KEGG_DRUG
86066003 SNOMEDCT_US
4019932 VANDF
004865 NDDF
270 RXNORM
372882007 SNOMEDCT_US
d00372 MMSL
93AKI1U6QF UNII
1429 INN_ID
CHEMBL1167 ChEMBL_ID
DB00919 DRUGBANK_ID
CHEMBL1200407 ChEMBL_ID
22189-32-8 SECONDARY_CAS_RN
SCM PDB_CHEM_ID
SMI PDB_CHEM_ID
CHEBI:146260 CHEBI
15541 PUBCHEM_CID
CHEMBL3989571 ChEMBL_ID

Pharmaceutical products:

None