sorivudine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
uridine derivatives used as antiviral agents and as antineoplastics	2463	77181-69-2

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

sorivudine
brovavir
bravavir

Molecular weight: 349.14
Formula: C11H13BrN2O6
CLOGP: -1.15
LIPINSKI: 0
HAC: 8
HDO: 4
TPSA: 119.33
ALOGS: -1.37
ROTB: 3

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Bocci G, Oprea TI, Benet LZ

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000998	Antiviral Agents
MeSH PA	D004791	Enzyme Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.1	acidic
pKa2	12.34	acidic
pKa3	12.78	acidic
pKa4	13.38	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Thymidine kinase, mitochondrial	Kinase	O00142	KITM_HUMAN		Ki	4.98		CHEMBL
Thymidine kinase	Kinase		KITH_HHV1		IC50	5.44		CHEMBL
Thymidine kinase	Kinase		KITH_VZVD		IC50	5.49		CHEMBL
Deoxynucleoside kinase	Kinase		DNK_DROME		IC50	4.55		CHEMBL

External reference:

ID	Source
D01734	KEGG_DRUG
C0207628	UMLSCUI
CHEBI:32152	CHEBI
CHEMBL70046	ChEMBL_ID
DB11998	DRUGBANK_ID
C031368	MESH_SUPPLEMENTAL_RECORD_UI
5282192	PUBCHEM_CID
6695	INN_ID
C7VOZ162LV	UNII

Pharmaceutical products:

None