sorbitol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2462 50-70-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • D-Sorbitol
  • sorbitol
  • (-)-Sorbitol
  • D-Glucitol
  • glucarine
  • L-Gulitol
A polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures. It is also used in many manufacturing processes, as a pharmaceutical aid, and in several research applications.
  • Molecular weight: 182.17
  • Formula: C6H14O6
  • CLOGP: -2.05
  • LIPINSKI: 1
  • HAC: 6
  • HDO: 6
  • TPSA: 121.38
  • ALOGS: 0.10
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 g O

ADMET properties:

PropertyValueReference
S (Water solubility) 2350 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
Aug. 20, 1971 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Transurethral resection syndrome 35.13 28.39 4 462 13 34956452
Biopsy rectum abnormal 28.61 28.39 3 463 3 34956462

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Crystal deposit intestine 50.02 24.74 7 707 221 79743453
Biopsy rectum abnormal 39.73 24.74 4 710 4 79743670
Rectal ulcer 34.48 24.74 7 707 2097 79741577
Excessive granulation tissue 33.37 24.74 6 708 946 79742728
Gastrointestinal necrosis 32.72 24.74 8 706 5557 79738117

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A06AD18 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Osmotically acting laxatives
ATC A06AG07 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Enemas
ATC B05CX02 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
IRRIGATING SOLUTIONS
Other irrigating solutions
ATC V04CC01 VARIOUS
DIAGNOSTIC AGENTS
OTHER DIAGNOSTIC AGENTS
Tests for bile duct patency
MeSH PA D002400 Cathartics
MeSH PA D005421 Flavoring Agents
MeSH PA D005503 Food Additives
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D007202 Indicators and Reagents
MeSH PA D013549 Sweetening Agents
CHEBI has role CHEBI:25212 metabolites
CHEBI has role CHEBI:50503 laxante
CHEBI has role CHEBI:50505 sweeteners
CHEBI has role CHEBI:75325 cathartics
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:75772 S. cerevisiae metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:77969 food humectants
CHEBI has role CHEBI:76924 plant metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Unknown Oral Substance Toxicity indication
Bowel sounds absent contraindication 16268000
Hypovolemia contraindication 28560003
Gastrointestinal perforation contraindication 51875005
Gastrointestinal hemorrhage contraindication 74474003
Gastrointestinal obstruction contraindication 126765001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.21 acidic
pKa2 13.75 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4017867 VUID
N0000146220 NUI
4017867 VANDF
C0037688 UMLSCUI
CHEBI:30911 CHEBI
SOR PDB_CHEM_ID
CHEMBL1682 ChEMBL_ID
DB01638 DRUGBANK_ID
D013012 MESH_DESCRIPTOR_UI
5780 PUBCHEM_CID
506T60A25R UNII
9945 RXNORM
11078 MMSL
5502 MMSL
d04159 MMSL
002599 NDDF
19839007 SNOMEDCT_US
412513004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Sorbitol HUMAN PRESCRIPTION DRUG LABEL 1 0264-2301 IRRIGANT 3.30 g IRRIGATION NDA 21 sections
Sorbitol HUMAN PRESCRIPTION DRUG LABEL 1 0338-0295 IRRIGANT 30 g IRRIGATION NDA 15 sections
Sorbitol HUMAN PRESCRIPTION DRUG LABEL 1 0338-0295 IRRIGANT 30 g IRRIGATION NDA 15 sections
Sorbitol-Mannitol HUMAN PRESCRIPTION DRUG LABEL 2 0990-7981 IRRIGANT 2.70 g URETHRAL NDA 12 sections
Sorbitol-Mannitol HUMAN PRESCRIPTION DRUG LABEL 2 0990-7981 IRRIGANT 2.70 g URETHRAL NDA 12 sections
Sorbitol HUMAN OTC DRUG LABEL 1 52471-111 SOLUTION 1 g RECTAL OTC monograph not final 8 sections
Sorbitol HUMAN OTC DRUG LABEL 1 54162-700 SOLUTION 258.20 g ORAL OTC monograph not final 8 sections
SORBITOL HUMAN OTC DRUG LABEL 1 57896-435 SOLUTION 13.50 g RECTAL OTC monograph not final 10 sections
GeriCare Sorbitol Solution HUMAN OTC DRUG LABEL 1 57896-758 LIQUID 70 mg RECTAL OTC monograph not final 10 sections
Trofresh HUMAN OTC DRUG LABEL 2 58354-106 SPRAY 0.06 g ORAL OTC monograph not final 8 sections
CHI. JOA (Anti-inflammatory effect, antibacterial effect, stomatitis improvement, plaque removal) HUMAN OTC DRUG LABEL 10 77008-4285 POWDER 1 g TOPICAL unapproved drug other 6 sections
Onsaemiro Damda HUMAN OTC DRUG LABEL 8 82341-302 LIQUID 0.30 g TOPICAL unapproved drug other 11 sections
Onsaemiro Damda HUMAN OTC DRUG LABEL 8 82341-302 LIQUID 0.30 g TOPICAL unapproved drug other 11 sections
Anubis Barcelona HUMAN OTC DRUG LABEL 11 83021-877 CONCENTRATE 0.05 g TOPICAL OTC monograph final 6 sections