sorbitol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2462 50-70-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • D-Sorbitol
  • sorbitol
  • (-)-Sorbitol
  • D-Glucitol
  • glucarine
  • L-Gulitol
A polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures. It is also used in many manufacturing processes, as a pharmaceutical aid, and in several research applications.
  • Molecular weight: 182.17
  • Formula: C6H14O6
  • CLOGP: -2.05
  • LIPINSKI: 1
  • HAC: 6
  • HDO: 6
  • TPSA: 121.38
  • ALOGS: 0.10
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Aug. 20, 1971 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC A06AD18 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Osmotically acting laxatives
ATC A06AG07 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Enemas
ATC B05CX02 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
IRRIGATING SOLUTIONS
Other irrigating solutions
ATC V04CC01 VARIOUS
DIAGNOSTIC AGENTS
OTHER DIAGNOSTIC AGENTS
Tests for bile duct patency
MeSH PA D002400 Cathartics
MeSH PA D005421 Flavoring Agents
MeSH PA D005503 Food Additives
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D007202 Indicators and Reagents
MeSH PA D013549 Sweetening Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Unknown Oral Substance Toxicity indication
Bowel sounds absent contraindication 16268000
Hypovolemia contraindication 28560003
Gastrointestinal perforation contraindication 51875005
Gastrointestinal hemorrhage contraindication 74474003
Gastrointestinal obstruction contraindication 126765001

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.21 acidic
pKa2 13.75 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4017867 VUID
N0000146220 NUI
C0037688 UMLSCUI
506T60A25R UNII
412513004 SNOMEDCT_US
4017867 VANDF
11078 MMSL
9945 RXNORM
19839007 SNOMEDCT_US
5502 MMSL
d04159 MMSL
002599 NDDF
5780 PUBCHEM_CID
CHEBI:30911 CHEBI
CHEMBL1682 ChEMBL_ID
SOR PDB_CHEM_ID
DB01638 DRUGBANK_ID
D013012 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Sorbitol HUMAN PRESCRIPTION DRUG LABEL 1 0264-2301 IRRIGANT 3.30 g IRRIGATION NDA 13 sections
Sorbitol HUMAN PRESCRIPTION DRUG LABEL 1 0338-0295 IRRIGANT 30 g IRRIGATION NDA 11 sections
Sorbitol-Mannitol HUMAN PRESCRIPTION DRUG LABEL 2 0409-7981 IRRIGANT 2.70 g URETHRAL NDA 12 sections
Sorbitol-Mannitol HUMAN PRESCRIPTION DRUG LABEL 2 0990-7981 IRRIGANT 2.70 g URETHRAL NDA 12 sections
Sorbitol HUMAN OTC DRUG LABEL 1 52471-111 SOLUTION 1 g RECTAL OTC monograph not final 8 sections
Sorbitol HUMAN OTC DRUG LABEL 1 54162-700 SOLUTION 258.20 g ORAL OTC monograph not final 8 sections
Darzalex Faspro HUMAN PRESCRIPTION DRUG LABEL 4 57894-503 INJECTION 735.10 mg SUBCUTANEOUS BLA 18 sections
SORBITOL HUMAN OTC DRUG LABEL 1 57896-435 SOLUTION 13.50 g RECTAL OTC monograph not final 9 sections
Trofresh HUMAN OTC DRUG LABEL 2 58354-106 SPRAY 0.06 g ORAL OTC monograph not final 8 sections