sivelestat Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
elastase inhibitors 2452 127373-66-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sivelestat sodium hydrate
  • elaspol
  • sivelestat sodium
  • sivelestat
inhibitor of neutrophil elastase; structure given in first source
  • Molecular weight: 434.46
  • Formula: C20H22N2O7S
  • CLOGP: 2.77
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 3
  • TPSA: 138.87
  • ALOGS: -4.46
  • ROTB: 8

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None PMDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011480 Protease Inhibitors
MeSH PA D015842 Serine Proteinase Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Acute lung injury indication 315345002

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.84 acidic
pKa2 7.84 acidic
pKa3 13.07 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Neutrophil elastase Enzyme Ki 6.70 CHEMBL IUPHAR
Myeloblastin Enzyme IC50 6.47 CHEMBL
Neutrophil elastase Enzyme IC50 6.84 CHEMBL

External reference:

IDSource
D03788 KEGG_DRUG
201677-61-4 SECONDARY_CAS_RN
C0130137 UMLSCUI
CHEBI:32133 CHEBI
CHEMBL76688 ChEMBL_ID
CHEMBL3182314 ChEMBL_ID
CHEMBL2107493 ChEMBL_ID
DB12863 DRUGBANK_ID
C069195 MESH_SUPPLEMENTAL_RECORD_UI
107706 PUBCHEM_CID
6441 IUPHAR_LIGAND_ID
7703 INN_ID
DWI62G0P59 UNII

Pharmaceutical products:

None