Stem definition | Drug id | CAS RN |
---|---|---|
antibacterials, nalidixic acid derivatives | 2449 | 127254-12-0 |
Dose | Unit | Route |
---|---|---|
0.10 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 75 % | Benet LZ, Broccatelli F, Oprea TI |
BA (Bioavailability) | 89 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 1.50 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 3.70 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.51 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 6.60 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Jan. 25, 2008 | PMDA | Daiichi Sankyo |
None
None
None
None
Source | Code | Description |
---|---|---|
ATC | J01MA21 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE QUINOLONE ANTIBACTERIALS Fluoroquinolones |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
MeSH PA | D000970 | Antineoplastic Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D059005 | Topoisomerase II Inhibitors |
MeSH PA | D059003 | Topoisomerase Inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Urinary tract infectious disease | indication | 68566005 | |
Respiratory tract infection | indication | 275498002 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 5.69 | acidic |
pKa2 | 10.5 | Basic |
pKa3 | 1.75 | Basic |
None
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Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
DNA gyrase subunit B | Enzyme | WOMBAT-PK | |||||||
DNA topoisomerase 4 subunit A | Enzyme | WOMBAT-PK |
ID | Source |
---|---|
D02475 | KEGG_DRUG |
C0171447 | UMLSCUI |
CHEBI:4304 | CHEBI |
CHEMBL3989504 | ChEMBL_ID |
CHEMBL108821 | ChEMBL_ID |
DB13261 | DRUGBANK_ID |
C076246 | MESH_SUPPLEMENTAL_RECORD_UI |
461399 | PUBCHEM_CID |
11040 | IUPHAR_LIGAND_ID |
9TD681796G | UNII |
163253-35-8 | SECONDARY_CAS_RN |
None