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simfibrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| clofibrate derivatives, peroxisome proliferator activated receptor-alpha(PPAR-alpha) agonists | 2444 | 14929-11-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAPK12,MAPK7,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CG,PRKDC,STK33,TEK,TTK | 27 | |||
| kinase-selectivity-class | ACVR2B,AXL,BRAF,ERBB2,GRK2,PDK4 | 6 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pld-class | Phospholipidosis risk class (1 = positive, 0 = negative) | 1 | Moderate | 0.75 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C10AB06 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, PLAIN Fibrates |
| MeSH PA | D000963 | Antimetabolites |
| MeSH PA | D000924 | Anticholesteremic Agents |
| MeSH PA | D000960 | Hypolipidemic Agents |
| MeSH PA | D057847 | Lipid Regulating Agents |
| CHEBI has role | CHEBI:35554 | cardiovascular drug |
| CHEBI has role | CHEBI:24527 | herbicide |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:35679 | antilipemic drug |
| CHEBI has role | CHEBI:35821 | anticholesteremic drug |
| CHEBI has role | CHEBI:70782 | PPARα agonist |
| CHEBI has role | CHEBI:83399 | marine xenobiotic metabolite |
Related Drugs by ATC class:
C10AB Fibrates 11 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D01212 | KEGG_DRUG |
| C0074551 | UMLSCUI |
| CHEBI:32131 | CHEBI |
| CHEMBL2105435 | ChEMBL_ID |
| DB13433 | DRUGBANK_ID |
| C003278 | MESH_SUPPLEMENTAL_RECORD_UI |
| 2732 | INN_ID |
| L2R75RQX26 | UNII |
| 5217 | PUBCHEM_CID |
| C0009003 | UMLSCUI |
| 2797 | PUBCHEM_CID |
| 2439 | INN_ID |
| D002995 | MESH_DESCRIPTOR_UI |
| CHEBI:34648 | CHEBI |
Pharmaceutical products:
None