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silymarin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	2443	65666-07-1

Description:

Molecule	Description
Synonyms: silymarin	A mixture of flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum. It consists primarily of silybin and its isomers, silicristin and silidianin. Silymarin displays antioxidant and membrane stabilizing activity. It protects various tissues and organs against chemical injury, and shows potential as an antihepatoxic agent. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

silymarin

A mixture of flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum. It consists primarily of silybin and its isomers, silicristin and silidianin. Silymarin displays antioxidant and membrane stabilizing activity. It protects various tissues and organs against chemical injury, and shows potential as an antihepatoxic agent.

Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A05BA03	ALIMENTARY TRACT AND METABOLISM BILE AND LIVER THERAPY LIVER THERAPY, LIPOTROPICS Liver therapy
MeSH PA	D000975	Antioxidants
MeSH PA	D020011	Protective Agents
CHEBI has role	CHEBI:22586	antioxidants
CHEBI has role	CHEBI:35610	antineoplastic agents
CHEBI has role	CHEBI:62868	hepatoprotective agents
CHEBI has role	CHEBI:76924	plant metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Type	Activity value (-log[M])	Bioact source
Urokinase-type plasminogen activator	Enzyme	P00749	UROK_HUMAN	IC50	4.68	CHEMBL
Carbonic anhydrase 2	Enzyme	P00918	CAH2_HUMAN	Ki	5.60	CHEMBL
Carbonic anhydrase 1	Enzyme	P00915	CAH1_HUMAN	Ki	5.83	CHEMBL
Carbonic anhydrase 4	Enzyme	P22748	CAH4_HUMAN	Ki	5.05	CHEMBL
Carbonic anhydrase 9	Enzyme	Q16790	CAH9_HUMAN	Ki	4.99	CHEMBL
Carbonic anhydrase 12	Enzyme	O43570	CAH12_HUMAN	Ki	5.04	CHEMBL
Prothrombin	Enzyme	P00734	THRB_HUMAN	Kd	4.73	CHEMBL
Carbonic anhydrase 5A, mitochondrial	Enzyme	P35218	CAH5A_HUMAN	Ki	5.39	CHEMBL
Carbonic anhydrase 5B, mitochondrial	Enzyme	Q9Y2D0	CAH5B_HUMAN	Ki	5.34	CHEMBL
Carbonic anhydrase 7	Enzyme	P43166	CAH7_HUMAN	Ki	5.33	CHEMBL
Carbonic anhydrase 3	Enzyme	P07451	CAH3_HUMAN	Ki	5.19	CHEMBL
Carbonic anhydrase 6	Enzyme	P23280	CAH6_HUMAN	Ki	5.01	CHEMBL
Carbonic anhydrase 14	Enzyme	Q9ULX7	CAH14_HUMAN	Ki	4.93	CHEMBL
Carbonic anhydrase 13	Enzyme	Q8N1Q1	CAH13_HUMAN	Ki	5.32	CHEMBL
Polyphenol oxidase 2	Enzyme		PPO2_AGABI	Ki	6.16	CHEMBL
Carbonic anhydrase 15	Enzyme		CAH15_MOUSE	Ki	6.19	CHEMBL
Xanthine dehydrogenase/oxidase	Enzyme		XDH_RAT	IC50	4.10	CHEMBL
P-glycoprotein 3	Transporter		MDR1A_MOUSE	Kd	5.17	CHEMBL
Solute carrier family 2, facilitated glucose transporter member 4	Transporter		GLUT4_MOUSE	Ki	4.22	CHEMBL

External reference:

ID	Source
N0000167027	NUI
C0037135	UMLSCUI
CHEBI:9144	CHEBI
CHEMBL431701	ChEMBL_ID
CHEMBL9509	ChEMBL_ID
CHEMBL4630684	ChEMBL_ID
D012838	MESH_DESCRIPTOR_UI
31553	PUBCHEM_CID
9794	RXNORM
NOCODE	MMSL
004366	NDDF

Pharmaceutical products:

None