sertraline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
serotonin reuptake inhibitors 2436 79617-96-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sertraline
  • sertraline hydrochloride
  • sertraline HCl
A selective serotonin uptake inhibitor that is used in the treatment of depression.
  • Molecular weight: 306.23
  • Formula: C17H17Cl2N
  • CLOGP: 5.35
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 1
  • TPSA: 12.03
  • ALOGS: -6.32
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
50 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 3.80 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.20 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 9.33 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 44 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Dec. 30, 1991 FDA PFIZER

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Intentional self-injury 1227.02 10.02 913 219037 24079 56048038
Intentional overdose 1048.00 10.02 1311 218639 66806 56005311
Serotonin syndrome 908.00 10.02 784 219166 25706 56046411
Suicide attempt 840.18 10.02 1082 218868 56754 56015363
Drug abuse 781.11 10.02 1132 218818 66478 56005639
Suicidal ideation 777.93 10.02 1041 218909 56701 56015416
Rheumatoid arthritis 759.45 10.02 274 219676 382330 55689787
Anxiety 663.68 10.02 1955 217995 191217 55880900
Depression 633.15 10.02 1838 218112 178279 55893838
Hand deformity 468.75 10.02 12 219938 134480 55937637
Systemic lupus erythematosus 459.38 10.02 76 219874 180002 55892115
Contraindicated product administered 459.14 10.02 86 219864 186200 55885917
Synovitis 454.33 10.02 50 219900 161255 55910862
Drug interaction 438.72 10.02 1801 218149 207954 55864163
Agitation 414.18 10.02 767 219183 55269 56016848
Glossodynia 400.94 10.02 59 219891 152399 55919718
Completed suicide 359.96 10.02 1246 218704 132587 55939530
Drug intolerance 351.07 10.02 311 219639 264507 55807610
Joint swelling 350.93 10.02 369 219581 289431 55782686
Tremor 341.98 10.02 1146 218804 119943 55952174
Treatment failure 339.13 10.02 121 219829 170271 55901846
Arthropathy 318.76 10.02 194 219756 200081 55872036
Infusion related reaction 302.19 10.02 225 219725 208706 55863411
Pericarditis 298.56 10.02 37 219913 108886 55963231
Akathisia 292.16 10.02 254 219696 8398 56063719
Toxicity to various agents 292.10 10.02 1683 218267 222881 55849236
Alopecia 285.37 10.02 441 219509 293017 55779100
Withdrawal syndrome 267.23 10.02 345 219605 18117 56054000
Swelling 261.28 10.02 332 219618 239439 55832678
Drug ineffective 255.84 10.02 2332 217618 916657 55155460
Sopor 251.17 10.02 357 219593 20565 56051552
Abnormal behaviour 249.42 10.02 350 219600 19922 56052195
Panic attack 226.68 10.02 336 219614 20111 56052006
Hallucination 225.28 10.02 554 219396 48595 56023522
Duodenal ulcer perforation 224.34 10.02 10 219940 68332 56003785
Therapeutic product effect decreased 223.17 10.02 200 219750 169252 55902865
Abdominal discomfort 221.75 10.02 470 219480 276804 55795313
Wound 221.39 10.02 134 219816 138670 55933447
Helicobacter infection 218.65 10.02 18 219932 73250 55998867
Overdose 200.90 10.02 883 219067 104947 55967170
Hepatic enzyme increased 196.44 10.02 228 219722 171156 55900961
Somnolence 194.47 10.02 1197 218753 162216 55909901
Rash 192.43 10.02 1135 218815 491912 55580205
Aggression 191.93 10.02 324 219626 21682 56050435
Arthralgia 189.41 10.02 1167 218783 500502 55571615
Hyponatraemia 189.18 10.02 846 219104 101293 55970824
Hallucination, auditory 188.56 10.02 229 219721 11295 56060822
Bruxism 185.84 10.02 129 219821 3037 56069080
Mania 183.76 10.02 226 219724 11294 56060823
Folliculitis 177.36 10.02 9 219941 54970 56017147
Discomfort 176.44 10.02 176 219774 141585 55930532
Mydriasis 166.69 10.02 211 219739 10860 56061257
Paranoia 165.32 10.02 207 219743 10537 56061580
Product use issue 164.50 10.02 297 219653 185744 55886373
Restlessness 160.08 10.02 334 219616 26252 56045865
Nasopharyngitis 159.21 10.02 396 219554 220563 55851554
Hypersensitivity 157.74 10.02 496 219454 255912 55816205
Rheumatoid factor positive 157.47 10.02 38 219912 69022 56003095
Muscle injury 153.63 10.02 14 219936 52486 56019631
Psychotic disorder 147.77 10.02 301 219649 23257 56048860
Off label use 147.65 10.02 1426 218524 554754 55517363
Peripheral swelling 144.40 10.02 454 219496 234272 55837845
Disorientation 144.33 10.02 390 219560 36223 56035894
Extrapyramidal disorder 142.67 10.02 207 219743 12149 56059968
Drug withdrawal syndrome 137.57 10.02 309 219641 25548 56046569
Pain 136.49 10.02 1801 218149 661383 55410734
Self-injurious ideation 136.18 10.02 95 219855 2255 56069862
Tic 133.59 10.02 75 219875 1196 56070921
Dyskinesia 133.24 10.02 328 219622 28780 56043337
Stomatitis 130.69 10.02 168 219782 120642 55951475
Blister 130.03 10.02 140 219810 108747 55963370
Electrocardiogram QT prolonged 129.36 10.02 488 219462 54100 56018017
Depressed mood 129.24 10.02 373 219577 35986 56036131
Anger 126.78 10.02 190 219760 11482 56060635
Dizziness 125.51 10.02 2115 217835 374025 55698092
Insomnia 121.37 10.02 1214 218736 190646 55881471
Infection 121.16 10.02 390 219560 199816 55872301
Lower respiratory tract infection 120.73 10.02 163 219787 114631 55957486
Disturbance in attention 120.70 10.02 339 219611 32201 56039916
Impaired healing 119.73 10.02 98 219852 86743 55985374
Galactorrhoea 118.87 10.02 108 219842 3787 56068330
Pyrexia 118.59 10.02 1056 218894 417717 55654400
Delusion 118.18 10.02 180 219770 11035 56061082
Irritability 117.45 10.02 316 219634 29272 56042845
Crying 117.18 10.02 259 219691 21181 56050936
Hallucinations, mixed 112.73 10.02 111 219839 4313 56067804
Seizure 111.56 10.02 854 219096 124265 55947852
Feeling abnormal 110.93 10.02 897 219053 132705 55939412
C-reactive protein abnormal 107.21 10.02 10 219940 36799 56035318
Confusional state 106.21 10.02 1262 218688 206893 55865224
Apathy 104.85 10.02 142 219808 7812 56064305
Myoclonus 104.68 10.02 202 219748 15001 56057116
Homicidal ideation 103.56 10.02 71 219879 1637 56070480
Sinusitis 103.48 10.02 409 219541 197172 55874945
Muscle rigidity 99.60 10.02 162 219788 10509 56061608
Thinking abnormal 98.38 10.02 155 219795 9786 56062331
Poisoning deliberate 98.24 10.02 155 219795 9798 56062319
Febrile neutropenia 97.31 10.02 164 219786 105381 55966736
General physical health deterioration 96.80 10.02 340 219610 169670 55902447
Emotional distress 95.97 10.02 295 219655 29468 56042649
Hyperhidrosis 95.80 10.02 663 219287 93425 55978692
Dystonia 94.19 10.02 172 219778 12249 56059868
Nightmare 93.92 10.02 205 219745 16621 56055496
Hyperreflexia 93.59 10.02 109 219841 5141 56066976
Hyperprolactinaemia 93.55 10.02 92 219858 3569 56068548
Loss of consciousness 93.38 10.02 739 219211 108610 55963507
Inappropriate antidiuretic hormone secretion 91.34 10.02 180 219770 13576 56058541
Psoriatic arthropathy 90.76 10.02 93 219857 73915 55998202
Treatment noncompliance 90.39 10.02 307 219643 32316 56039801
Psychomotor hyperactivity 88.84 10.02 147 219803 9673 56062444
Irritable bowel syndrome 88.61 10.02 82 219868 68376 56003741
Hallucination, visual 87.66 10.02 204 219746 17264 56054853
Mood swings 85.60 10.02 197 219753 16550 56055567
Suicidal behaviour 85.33 10.02 73 219877 2360 56069757
Obsessive-compulsive disorder 85.29 10.02 88 219862 3618 56068499
Ill-defined disorder 84.20 10.02 86 219864 68457 56003660
Product substitution issue 82.78 10.02 179 219771 14420 56057697
Mental disorder 81.81 10.02 240 219710 23364 56048753
Homicide 79.90 10.02 36 219914 348 56071769
Neuroleptic malignant syndrome 79.63 10.02 153 219797 11325 56060792
Malignant neoplasm progression 75.83 10.02 106 219844 73481 55998636
Hip arthroplasty 75.78 10.02 28 219922 38595 56033522
Social avoidant behaviour 75.36 10.02 73 219877 2779 56069338
Anorgasmia 75.21 10.02 39 219911 526 56071591
Infarction 74.40 10.02 68 219882 2403 56069714
Gastrointestinal disorder 74.24 10.02 211 219739 112491 55959626
Major depression 73.33 10.02 117 219833 7467 56064650
Tardive dyskinesia 72.36 10.02 120 219830 7911 56064206
Emotional disorder 72.30 10.02 153 219797 12142 56059975
Libido decreased 71.99 10.02 66 219884 2342 56069775
Foetal exposure during pregnancy 71.70 10.02 292 219658 33531 56038586
Intentional product use issue 71.53 10.02 179 219771 99554 55972563
Knee arthroplasty 71.53 10.02 42 219908 44217 56027900
Poisoning 71.39 10.02 156 219794 12657 56059460
Salivary hypersecretion 71.26 10.02 111 219839 6939 56065178
Delirium 71.14 10.02 342 219608 42175 56029942
C-reactive protein increased 70.93 10.02 124 219826 78560 55993557
Abnormal dreams 69.88 10.02 131 219819 9518 56062599
Bradyphrenia 69.39 10.02 106 219844 6514 56065603
Oromandibular dystonia 68.69 10.02 34 219916 413 56071704
Hypomania 68.42 10.02 90 219860 4812 56067305
Amenorrhoea 67.59 10.02 124 219826 8862 56063255
Parkinsonism 67.15 10.02 128 219822 9418 56062699
Trismus 67.01 10.02 76 219874 3482 56068635
Muscle twitching 64.99 10.02 174 219776 16068 56056049
Neutropenia 63.62 10.02 360 219590 157807 55914310
Formication 63.50 10.02 78 219872 3892 56068225
Renal impairment 63.39 10.02 138 219812 80575 55991542
Product complaint 63.06 10.02 141 219809 11619 56060498
Maculopathy 63.01 10.02 57 219893 1987 56070130
Dysarthria 62.50 10.02 313 219637 39237 56032880
Drug dependence 61.50 10.02 211 219739 22322 56049795
Reversible cerebral vasoconstriction syndrome 61.23 10.02 60 219890 2317 56069800
Impulsive behaviour 60.72 10.02 49 219901 1458 56070659
Activation syndrome 60.56 10.02 25 219925 191 56071926
Yawning 59.69 10.02 42 219908 1011 56071106
Rhabdomyolysis 59.55 10.02 315 219635 40343 56031774
Mental impairment 58.89 10.02 144 219806 12578 56059539
Psychomotor retardation 58.54 10.02 72 219878 3597 56068520
Bradykinesia 58.50 10.02 83 219867 4771 56067346
Generalised tonic-clonic seizure 58.44 10.02 238 219712 27328 56044789
Tachycardia 58.43 10.02 652 219298 105224 55966893
Blood prolactin increased 57.82 10.02 68 219882 3241 56068876
Gestational diabetes 57.80 10.02 109 219841 7955 56064162
Drug screen false positive 56.73 10.02 37 219913 783 56071334
Agitation neonatal 56.48 10.02 31 219919 472 56071645
Flat affect 56.39 10.02 45 219905 1317 56070800
Musculoskeletal stiffness 55.98 10.02 368 219582 155639 55916478
Intentional product misuse 55.42 10.02 368 219582 51136 56020981
Memory impairment 54.30 10.02 547 219403 86010 55986107
Fall 53.88 10.02 1801 218149 355709 55716408
Euphoric mood 53.23 10.02 75 219875 4283 56067834
Thrombocytopenia 52.66 10.02 314 219636 135910 55936207
Newborn persistent pulmonary hypertension 52.38 10.02 23 219927 208 56071909
Schizophrenia 52.01 10.02 122 219828 10377 56061740
Negative thoughts 51.77 10.02 36 219914 850 56071267
Fear 51.10 10.02 151 219799 14757 56057360
Colitis microscopic 51.02 10.02 102 219848 7773 56064344
Persistent genital arousal disorder 50.70 10.02 25 219925 301 56071816
Mood altered 50.37 10.02 140 219810 13215 56058902
Drug withdrawal syndrome neonatal 50.28 10.02 50 219900 1966 56070151
Vertigo 50.00 10.02 375 219575 54197 56017920
Psychotic symptom 49.90 10.02 42 219908 1327 56070790
Stiff person syndrome 49.02 10.02 25 219925 325 56071792
Cardiac arrest 48.75 10.02 534 219416 85780 55986337
Burning mouth syndrome 48.62 10.02 27 219923 421 56071696
Abnormal weight gain 48.19 10.02 43 219907 1472 56070645
Respiratory arrest 48.13 10.02 242 219708 30383 56041734
Pancytopenia 48.09 10.02 181 219769 88534 55983583
Speech disorder 47.92 10.02 280 219670 37213 56034904
Disease progression 47.53 10.02 230 219720 104943 55967174
Depressed level of consciousness 47.38 10.02 380 219570 56053 56016064
Loss of libido 47.30 10.02 39 219911 1197 56070920
Cytomegalovirus infection 47.28 10.02 9 219941 19287 56052830
Inflammation 47.20 10.02 127 219823 68944 56003173
Pleurothotonus 47.07 10.02 40 219910 1281 56070836
Cholecystitis chronic 46.90 10.02 112 219838 9636 56062481
Intrusive thoughts 46.72 10.02 20 219930 169 56071948
Eye movement disorder 46.46 10.02 74 219876 4715 56067402
Torticollis 45.92 10.02 45 219905 1738 56070379
Drug screen positive 45.90 10.02 62 219888 3402 56068715
Musculoskeletal pain 45.01 10.02 164 219786 80988 55991129
Flashback 44.94 10.02 18 219932 126 56071991
Cardiac failure 44.81 10.02 167 219783 81926 55990191
Anhedonia 43.55 10.02 110 219840 9804 56062313
Abulia 43.23 10.02 25 219925 423 56071694
Mucosal inflammation 42.78 10.02 63 219887 42747 56029370
Victim of chemical submission 42.46 10.02 24 219926 388 56071729
Therapeutic product effect incomplete 42.25 10.02 242 219708 105789 55966328
Restless legs syndrome 42.21 10.02 154 219796 16793 56055324
Palpitations 41.35 10.02 582 219368 99090 55973027
Tension 41.30 10.02 54 219896 2870 56069247
Balance disorder 41.20 10.02 469 219481 76051 55996066
Mobility decreased 41.04 10.02 223 219727 98768 55973349
Heavy menstrual bleeding 40.97 10.02 148 219802 16061 56056056
Psychomotor skills impaired 40.79 10.02 46 219904 2094 56070023
Affective disorder 40.49 10.02 76 219874 5527 56066590
Emotional poverty 40.49 10.02 22 219928 328 56071789
Sensation of foreign body 40.41 10.02 64 219886 4058 56068059
Depressive symptom 40.41 10.02 59 219891 3482 56068635
Syncope 40.25 10.02 620 219330 107579 55964538
Drowning 40.19 10.02 24 219926 432 56071685
Depersonalisation/derealisation disorder 40.09 10.02 36 219914 1243 56070874
Death 39.69 10.02 1023 218927 340403 55731714
Alcoholism 39.60 10.02 46 219904 2163 56069954
Catatonia 39.49 10.02 62 219888 3902 56068215
Amnesia 39.48 10.02 313 219637 46009 56026108
Hypersomnia 39.45 10.02 147 219803 16194 56055923
Sedation 39.30 10.02 252 219698 34602 56037515
Bone erosion 38.85 10.02 6 219944 14968 56057149
Pregnancy with implant contraceptive 38.62 10.02 46 219904 2222 56069895
Cycloplegia 38.36 10.02 9 219941 3 56072114
Arthritis 38.14 10.02 231 219719 99621 55972496
Conjunctival abrasion 38.04 10.02 11 219939 22 56072095
Clonus 37.62 10.02 63 219887 4186 56067931
Bipolar disorder 37.46 10.02 88 219862 7492 56064625
Retroplacental haematoma 36.99 10.02 16 219934 139 56071978
Pruritus 36.70 10.02 949 219001 315674 55756443
Rabbit syndrome 36.47 10.02 20 219930 304 56071813
Eosinophilic pneumonia acute 35.90 10.02 20 219930 314 56071803
Mental status changes 35.66 10.02 260 219690 37241 56034876
Hallucination, olfactory 35.49 10.02 18 219932 231 56071886
Paraesthesia 35.35 10.02 711 219239 129803 55942314
Tremor neonatal 35.11 10.02 15 219935 126 56071991
Maternal exposure during pregnancy 35.09 10.02 525 219425 189028 55883089
Vision blurred 34.67 10.02 485 219465 82458 55989659
Coma 34.57 10.02 371 219579 59284 56012833
Upper gastrointestinal haemorrhage 34.39 10.02 145 219805 16909 56055208
Conversion disorder 34.32 10.02 37 219913 1601 56070516
Cerebral vasoconstriction 34.26 10.02 31 219919 1081 56071036
Lethargy 34.16 10.02 329 219621 51112 56021005
Uterine perforation 33.77 10.02 77 219873 6428 56065689
Hyponatraemic seizure 33.50 10.02 21 219929 414 56071703
Swollen tongue 33.42 10.02 218 219732 30106 56042011
Bipolar I disorder 33.37 10.02 37 219913 1653 56070464
Pain in extremity 33.01 10.02 897 219053 296534 55775583
Pulmonary embolism 32.92 10.02 595 219355 106529 55965588
Therapeutic response unexpected 32.89 10.02 143 219807 16901 56055216
Injection site pain 32.72 10.02 296 219654 116822 55955295
Somatic symptom disorder of pregnancy 32.34 10.02 13 219937 92 56072025
Lung disorder 32.08 10.02 102 219848 52495 56019622
Thermal burn 31.95 10.02 68 219882 5417 56066700
Cardio-respiratory arrest 31.57 10.02 343 219607 54978 56017139
Nystagmus 31.41 10.02 70 219880 5755 56066362
Hyperthermia 31.39 10.02 87 219863 8198 56063919
Septic shock 31.12 10.02 127 219823 60708 56011409
Acute kidney injury 31.07 10.02 710 219240 240053 55832064
Neuropathy peripheral 30.99 10.02 255 219695 102638 55969479
Urinary incontinence 30.99 10.02 210 219740 29375 56042742
Disorganised speech 30.78 10.02 29 219921 1066 56071051
Phobia 30.64 10.02 18 219932 314 56071803
Bradycardia neonatal 30.64 10.02 26 219924 831 56071286
Psychiatric symptom 30.50 10.02 62 219888 4782 56067335
Fatigue 30.45 10.02 2661 217289 785891 55286226
Pneumonia 30.39 10.02 1291 218659 405807 55666310
Foaming at mouth 30.31 10.02 29 219921 1087 56071030
Alcohol abuse 30.16 10.02 38 219912 1946 56070171
Neonatal respiratory distress syndrome 30.15 10.02 45 219905 2709 56069408
Tinnitus 30.14 10.02 211 219739 29831 56042286
Borderline personality disorder 30 10.02 24 219926 705 56071412
Poverty of thought content 29.94 10.02 8 219942 10 56072107
Neonatal asphyxia 29.90 10.02 17 219933 278 56071839
Anaemia 29.88 10.02 806 219144 266705 55805412
Nervousness 29.82 10.02 205 219745 28810 56043307
Pancreatic fibrosis 29.72 10.02 12 219938 86 56072031
Alcohol poisoning 29.26 10.02 36 219914 1799 56070318
Hyponatraemic syndrome 29.23 10.02 21 219929 523 56071594
Disturbance in sexual arousal 29.14 10.02 12 219938 91 56072026
Device dislocation 29.00 10.02 169 219781 22437 56049680
Depression suicidal 28.85 10.02 34 219916 1624 56070493
Respiratory disorder neonatal 28.46 10.02 26 219924 918 56071199
Sepsis 28.45 10.02 380 219570 139460 55932657
Platelet count decreased 28.37 10.02 272 219678 106111 55966006
Osteoporosis 28.33 10.02 106 219844 51946 56020171
Dysphemia 28.09 10.02 41 219909 2419 56069698
Schizoaffective disorder bipolar type 28.04 10.02 13 219937 135 56071982
Suppressed lactation 27.90 10.02 19 219931 433 56071684
Liver injury 27.80 10.02 78 219872 41770 56030347
Violence-related symptom 27.55 10.02 18 219932 382 56071735
Pleural effusion 27.53 10.02 208 219742 85272 55986845
Muscle tightness 27.44 10.02 99 219851 10737 56061380
Perinatal depression 27.42 10.02 21 219929 578 56071539
Neutrophil count decreased 27.42 10.02 101 219849 49721 56022396
Unresponsive to stimuli 27.38 10.02 215 219735 31510 56040607
Antipsychotic drug level increased 27.29 10.02 47 219903 3195 56068922
Maternal drugs affecting foetus 27.23 10.02 61 219889 5032 56067085
Central vision loss 27.03 10.02 8 219942 18 56072099
Idiopathic intracranial hypertension 26.92 10.02 41 219909 2513 56069604
Inappropriate affect 26.81 10.02 24 219926 825 56071292
Confabulation 26.80 10.02 16 219934 288 56071829
Coordination abnormal 26.77 10.02 109 219841 12512 56059605
Herpes zoster 26.70 10.02 180 219770 75709 55996408
Caesarean section 26.60 10.02 129 219821 15962 56056155
Hemivertebra 26.54 10.02 12 219938 117 56072000
Creatinine renal clearance decreased 26.22 10.02 12 219938 14547 56057570
Somnambulism 26.13 10.02 60 219890 5032 56067085
Incoherent 26.12 10.02 54 219896 4215 56067902
Intermenstrual bleeding 25.85 10.02 73 219877 6954 56065163
Therapy non-responder 25.54 10.02 138 219812 61217 56010900
Antisocial behaviour 25.54 10.02 16 219934 315 56071802
Injection site erythema 25.15 10.02 188 219762 77260 55994857
Neutropenic sepsis 25.12 10.02 14 219936 15171 56056946
Substance abuse 25.10 10.02 55 219895 4470 56067647
Myelosuppression 24.93 10.02 19 219931 17436 56054681
Embedded device 24.69 10.02 43 219907 2950 56069167
Large for dates baby 24.62 10.02 18 219932 461 56071656
Haemophagocytic lymphohistiocytosis 24.46 10.02 4 219946 9568 56062549
Cold sweat 24.41 10.02 96 219854 10847 56061270
Mutism 24.30 10.02 29 219921 1404 56070713
Bone marrow failure 24.21 10.02 46 219904 28240 56043877
Leukopenia 24.10 10.02 170 219780 70770 56001347
Adrenal insufficiency 23.84 10.02 16 219934 15681 56056436
Factor XIII deficiency 23.72 10.02 10 219940 81 56072036
White blood cell count decreased 23.63 10.02 348 219602 125642 55946475
Herbal interaction 23.62 10.02 10 219940 82 56072035
Tachyphrenia 23.46 10.02 27 219923 1257 56070860
Bundle branch block right 23.34 10.02 55 219895 4692 56067425
Sexual dysfunction 23.30 10.02 45 219905 3343 56068774
Obsessive thoughts 23.30 10.02 18 219932 502 56071615
Fibromyalgia 23.22 10.02 137 219813 59466 56012651
Hereditary angioedema 23.21 10.02 69 219881 6766 56065351
Multiple sclerosis relapse 23.17 10.02 273 219677 44630 56027487
Dissociative disorder 23.06 10.02 14 219936 260 56071857
Abortion missed 22.95 10.02 30 219920 1594 56070523
Hypotonia neonatal 22.87 10.02 25 219925 1099 56071018
Plasma cell myeloma 22.86 10.02 99 219851 46547 56025570
Diplopia 22.79 10.02 147 219803 20222 56051895
Food interaction 22.77 10.02 21 219929 751 56071366
Post-traumatic stress disorder 22.77 10.02 53 219897 4485 56067632
Persistent foetal circulation 22.74 10.02 13 219937 215 56071902
Respiratory tract infection 22.67 10.02 69 219881 36002 56036115
Injection site bruising 22.59 10.02 76 219874 38445 56033672
Device placement issue 22.56 10.02 23 219927 932 56071185
Dissociation 22.45 10.02 38 219912 2547 56069570
Stress 22.45 10.02 339 219611 58571 56013546
Hallucination, gustatory 22.35 10.02 9 219941 64 56072053
Sleep-related eating disorder 22.04 10.02 21 219929 783 56071334
Mitochondrial encephalomyopathy 21.98 10.02 7 219943 22 56072095
Soliloquy 21.96 10.02 12 219938 181 56071936
Dyspnoea 21.88 10.02 2006 217944 590571 55481546
Alcohol intolerance 21.77 10.02 9 219941 69 56072048
Hypochloraemia 21.71 10.02 30 219920 1682 56070435
Foreign body in reproductive tract 21.67 10.02 17 219933 485 56071632
Tuberculosis 21.63 10.02 8 219942 11021 56061096
Grip strength decreased 21.59 10.02 19 219931 16237 56055880
Self esteem decreased 21.57 10.02 18 219932 562 56071555
Impaired reasoning 21.55 10.02 9 219941 71 56072046
Transient psychosis 21.44 10.02 8 219942 45 56072072
Right ventricular hypertrophy 21.43 10.02 19 219931 645 56071472
Hypersensitivity pneumonitis 21.40 10.02 36 219914 2401 56069716
Posture abnormal 21.37 10.02 34 219916 2164 56069953
Amniotic fluid volume increased 21.37 10.02 11 219939 146 56071971
Tenosynovitis 21.33 10.02 11 219939 12450 56059667
Pneumocystis jirovecii pneumonia 21.28 10.02 18 219932 15683 56056434
Tearfulness 21.13 10.02 46 219904 3722 56068395
Complication of device insertion 21.01 10.02 64 219886 6360 56065757
Parkinsonian gait 21.00 10.02 16 219934 437 56071680
Vomiting 20.97 10.02 2238 217712 495990 55576127
Environmental exposure 20.93 10.02 9 219941 77 56072040
Small for dates baby 20.84 10.02 44 219906 3486 56068631
Panic disorder 20.82 10.02 36 219914 2455 56069662
Anaphylactic shock 20.75 10.02 33 219917 21707 56050410
Judgement impaired 20.70 10.02 18 219932 595 56071522
Merycism 20.70 10.02 12 219938 204 56071913
Urine sodium decreased 20.60 10.02 11 219939 158 56071959
Slow response to stimuli 20.59 10.02 22 219928 942 56071175
Brain injury 20.49 10.02 63 219887 6292 56065825
Neonatal tachypnoea 20.48 10.02 8 219942 52 56072065
Haematoma muscle 20.35 10.02 22 219928 955 56071162
Device expulsion 20.34 10.02 195 219755 30254 56041863
Menstruation irregular 20.25 10.02 63 219887 6333 56065784
Postural orthostatic tachycardia syndrome 20.17 10.02 22 219928 965 56071152
Erythromelalgia 20.16 10.02 10 219940 122 56071995
Adverse event 20.16 10.02 130 219820 55246 56016871
Skin ulcer 20.12 10.02 80 219870 38528 56033589
Metabolic syndrome 20.10 10.02 26 219924 1367 56070750
Hypokinesia 19.99 10.02 101 219849 12702 56059415
Tongue spasm 19.97 10.02 8 219942 56 56072061
Photophobia 19.95 10.02 119 219831 15931 56056186
Drug hypersensitivity 19.87 10.02 1288 218662 273917 55798200
Maternal exposure during breast feeding 19.86 10.02 44 219906 3603 56068514
Congenital brain damage 19.82 10.02 5 219945 4 56072113
Gallbladder cholesterolosis 19.73 10.02 19 219931 718 56071399
Sluggishness 19.68 10.02 51 219899 4617 56067500
Drug dose titration not performed 19.54 10.02 16 219934 486 56071631
Cough 19.44 10.02 824 219126 259137 55812980
Bursitis 19.38 10.02 50 219900 27532 56044585
Injection site pruritus 19.34 10.02 91 219859 41840 56030277
Cataract 19.33 10.02 119 219831 51128 56020989
Femur-fibula-ulna complex 19.30 10.02 5 219945 5 56072112
Collagen-vascular disease 19.29 10.02 9 219941 95 56072022
Delusion of reference 19.20 10.02 9 219941 96 56072021
Miosis 19.11 10.02 63 219887 6529 56065588
Polymenorrhoea 19.00 10.02 23 219927 1130 56070987
Long QT syndrome 18.93 10.02 39 219911 3037 56069080
Blood creatinine increased 18.53 10.02 212 219738 79979 55992138
Target skin lesion 18.50 10.02 9 219941 105 56072012
Renal dysplasia 18.47 10.02 10 219940 148 56071969
Hypotonia 18.46 10.02 75 219875 8602 56063515
Flight of ideas 18.42 10.02 14 219936 381 56071736
Logorrhoea 18.38 10.02 33 219917 2319 56069798
Persistent depressive disorder 18.36 10.02 20 219930 876 56071241
Catastrophic reaction 18.35 10.02 6 219944 21 56072096
Ductus arteriosus premature closure 18.33 10.02 13 219937 317 56071800
Intracranial meningioma malignant 18.20 10.02 4 219946 0 56072117
Lack of spontaneous speech 18.18 10.02 10 219940 153 56071964
Type 2 diabetes mellitus 18.10 10.02 108 219842 46754 56025363
Infantile vomiting 17.99 10.02 9 219941 112 56072005
Bronchopulmonary aspergillosis 17.97 10.02 5 219945 8259 56063858
Suicide threat 17.93 10.02 6 219944 23 56072094
Congenital skin dimples 17.92 10.02 9 219941 113 56072004
Alcohol use 17.90 10.02 30 219920 1995 56070122
Negative symptoms in schizophrenia 17.85 10.02 9 219941 114 56072003
Joint range of motion decreased 17.81 10.02 46 219904 25319 56046798
Exposure during pregnancy 17.79 10.02 676 219274 135666 55936451
Somatic delusion 17.73 10.02 16 219934 556 56071561
Blood creatine phosphokinase increased 17.69 10.02 177 219773 27775 56044342
Presyncope 17.67 10.02 165 219785 25417 56046700
Heat stroke 17.53 10.02 18 219932 736 56071381
CYP3A4 polymorphism 17.52 10.02 8 219942 80 56072037
Dopamine dysregulation syndrome 17.46 10.02 10 219940 166 56071951
Water intoxication 17.45 10.02 14 219936 413 56071704
Pelvic pain 17.41 10.02 92 219858 11775 56060342
Ataxia 17.40 10.02 106 219844 14297 56057820
Palmar-plantar erythrodysaesthesia syndrome 17.38 10.02 35 219915 21030 56051087
Blood pressure diastolic abnormal 17.37 10.02 12 219938 11586 56060531
Hyperphagia 17.36 10.02 26 219924 1570 56070547
Illness anxiety disorder 17.31 10.02 9 219941 122 56071995
Altered state of consciousness 17.18 10.02 151 219799 22870 56049247
Red blood cell sedimentation rate increased 17.17 10.02 79 219871 36544 56035573
Hypokalaemia 17.16 10.02 487 219463 93950 55978167
Vanishing bile duct syndrome 17.11 10.02 17 219933 668 56071449
Urine chloride decreased 17.02 10.02 8 219942 86 56072031
Libido disorder 17.01 10.02 7 219943 53 56072064
Urinary retention 16.92 10.02 176 219774 27898 56044219
Neoplasm progression 16.90 10.02 66 219884 31950 56040167
Action tremor 16.87 10.02 12 219938 294 56071823
Neonatal seizure 16.83 10.02 14 219936 435 56071682
Gallbladder injury 16.82 10.02 23 219927 1277 56070840
Oral discomfort 16.81 10.02 71 219879 8284 56063833
Product taste abnormal 16.73 10.02 28 219922 1860 56070257
Pulmonary toxicity 16.71 10.02 5 219945 7878 56064239
Nausea 16.71 10.02 3305 216645 760873 55311244
Phalangeal hypoplasia 16.67 10.02 5 219945 12 56072105
Visceral congestion 16.66 10.02 12 219938 300 56071817
Tongue discolouration 16.62 10.02 36 219914 2903 56069214
Affect lability 16.61 10.02 81 219869 10044 56062073
Hypertonia 16.53 10.02 44 219906 4048 56068069
Electrocardiogram T wave abnormal 16.51 10.02 31 219919 2255 56069862
Head injury 16.48 10.02 160 219790 24906 56047211
Economic problem 16.48 10.02 28 219922 1883 56070234
Alkalosis hypochloraemic 16.40 10.02 9 219941 137 56071980
Lipidosis 16.39 10.02 5 219945 13 56072104
Biliary dyskinesia 16.37 10.02 33 219917 2530 56069587
Physical assault 16.30 10.02 19 219931 897 56071220
Diaphragmatic rupture 16.26 10.02 11 219939 248 56071869
Drug resistance 16.22 10.02 35 219915 20507 56051610
Myocardial fibrosis 16.22 10.02 17 219933 712 56071405
Muscle contracture 16.08 10.02 22 219928 1222 56070895
Delusional disorder, unspecified type 16.07 10.02 13 219937 388 56071729
Petit mal epilepsy 16.03 10.02 40 219910 3538 56068579
Snoring 16.01 10.02 40 219910 3541 56068576
Blood calcium decreased 16.01 10.02 44 219906 23725 56048392
Glucose tolerance impaired in pregnancy 15.97 10.02 4 219946 3 56072114
Hepatic function abnormal 15.94 10.02 75 219875 34483 56037634
Partner stress 15.83 10.02 12 219938 325 56071792
Social anxiety disorder 15.82 10.02 13 219937 397 56071720
Complication of device removal 15.80 10.02 46 219904 4458 56067659
Morbid thoughts 15.70 10.02 15 219935 561 56071556
Teratoma benign 15.69 10.02 7 219943 66 56072051
Screaming 15.69 10.02 36 219914 3018 56069099
Compulsions 15.65 10.02 10 219940 204 56071913
Dysphoria 15.61 10.02 48 219902 4794 56067323
Metastases to bone 15.60 10.02 33 219917 19475 56052642
Sciatica 15.47 10.02 51 219899 25959 56046158
Nephropathy toxic 15.40 10.02 7 219943 8520 56063597
Unintended pregnancy 15.40 10.02 50 219900 5141 56066976
Suspiciousness 15.34 10.02 12 219938 341 56071776
Distractibility 15.33 10.02 13 219937 415 56071702
Derealisation 15.32 10.02 20 219930 1061 56071056
Osteoarthritis 15.32 10.02 221 219729 80075 55992042
Diverticulitis 15.28 10.02 80 219870 35772 56036345
Ankylosing spondylitis 15.24 10.02 10 219940 9920 56062197
Marital problem 15.22 10.02 9 219941 159 56071958
Atrioventricular dissociation 15.15 10.02 10 219940 216 56071901
Ophthalmic vein thrombosis 15.15 10.02 10 219940 216 56071901
Adverse drug reaction 15.12 10.02 172 219778 64960 56007157
Thrombotic microangiopathy 15.11 10.02 9 219941 9402 56062715
Peritonitis 15.08 10.02 25 219925 16177 56055940
Attention-seeking behaviour 15.07 10.02 7 219943 73 56072044
Acute myeloid leukaemia 15.06 10.02 27 219923 16945 56055172
Infantile apnoea 15.06 10.02 18 219932 873 56071244
Serum serotonin increased 15.02 10.02 9 219941 163 56071954
Spleen congestion 14.92 10.02 8 219942 116 56072001
Postural tremor 14.88 10.02 10 219940 223 56071894
Athetosis 14.86 10.02 6 219944 43 56072074
Accommodation disorder 14.79 10.02 12 219938 360 56071757
May-Thurner syndrome 14.78 10.02 5 219945 20 56072097
Fear of weight gain 14.78 10.02 5 219945 20 56072097
Product odour abnormal 14.75 10.02 20 219930 1101 56071016
Joint hyperextension 14.70 10.02 11 219939 292 56071825
Decreased interest 14.66 10.02 35 219915 3011 56069106
Personality disorder 14.61 10.02 49 219901 5124 56066993
Morning sickness 14.59 10.02 16 219934 706 56071411
Asocial behaviour 14.58 10.02 5 219945 21 56072096
Impulse-control disorder 14.57 10.02 16 219934 707 56071410
Postpartum haemorrhage 14.52 10.02 26 219924 1823 56070294
Eosinophilic pneumonia 14.51 10.02 27 219923 1950 56070167
Leukaemoid reaction 14.51 10.02 9 219941 174 56071943
Pulmonary infarction 14.47 10.02 31 219919 2481 56069636
Hyperkalaemia 14.44 10.02 128 219822 50737 56021380
Aphasia 14.42 10.02 182 219768 30233 56041884
Cognitive disorder 14.42 10.02 271 219679 48862 56023255
Foetal death 14.31 10.02 69 219881 8518 56063599
Breast cancer metastatic 14.28 10.02 24 219926 15445 56056672
Lip blister 14.27 10.02 28 219922 2105 56070012
Cardiotoxicity 14.26 10.02 6 219944 7644 56064473
Gross motor delay 14.23 10.02 8 219942 128 56071989
Hypercapnic coma 14.20 10.02 9 219941 181 56071936
Oedema 14.09 10.02 230 219720 81690 55990427
Menopausal disorder 14.09 10.02 6 219944 50 56072067
Metastases to lung 14.05 10.02 15 219935 11703 56060414
Feeling guilty 14.03 10.02 14 219936 553 56071564
Psychogenic seizure 14.01 10.02 24 219926 1625 56070492
Pre-eclampsia 14.00 10.02 68 219882 8418 56063699
Basal cell carcinoma 13.96 10.02 51 219899 25170 56046947
Chorea 13.95 10.02 22 219928 1390 56070727
Transplant rejection 13.95 10.02 11 219939 9923 56062194
Urinary hesitation 13.89 10.02 27 219923 2015 56070102
Cholelithiasis 13.85 10.02 224 219726 39240 56032877
Urticaria 13.85 10.02 445 219505 144231 55927886
Communication disorder 13.85 10.02 29 219921 2284 56069833
Opisthotonus 13.81 10.02 11 219939 321 56071796
Ear infection 13.80 10.02 69 219881 31226 56040891
Female orgasmic disorder 13.79 10.02 6 219944 53 56072064
Overweight 13.76 10.02 36 219914 3278 56068839
Vasodilation procedure 13.72 10.02 5 219945 26 56072091
Aplastic anaemia 13.69 10.02 9 219941 8919 56063198
Heart rate decreased 13.67 10.02 97 219853 40330 56031787
Postictal headache 13.65 10.02 3 219947 0 56072117
Anaplastic large cell lymphoma T- and null-cell types stage IV 13.65 10.02 3 219947 0 56072117
Exposure via breast milk 13.62 10.02 25 219925 1787 56070330
Abnormal uterine bleeding 13.62 10.02 21 219929 1301 56070816
Blood pressure fluctuation 13.57 10.02 97 219853 40263 56031854
Gambling disorder 13.56 10.02 20 219930 1191 56070926
Localised infection 13.54 10.02 58 219892 27354 56044763
Analgesic drug level increased 13.52 10.02 25 219925 1797 56070320
Postmortem blood drug level increased 13.52 10.02 14 219936 578 56071539
Neoplasm malignant 13.51 10.02 57 219893 26998 56045119
Burnout syndrome 13.49 10.02 9 219941 198 56071919
Congenital tricuspid valve incompetence 13.46 10.02 7 219943 95 56072022
Breast cancer stage II 13.46 10.02 3 219947 5755 56066362
Blood cholesterol increased 13.42 10.02 201 219749 72378 55999739
Laryngomalacia 13.41 10.02 6 219944 57 56072060
Drug monitoring procedure incorrectly performed 13.40 10.02 8 219942 144 56071973
Panic reaction 13.32 10.02 39 219911 3791 56068326
Belligerence 13.30 10.02 8 219942 146 56071971
Drug reaction with eosinophilia and systemic symptoms 13.26 10.02 67 219883 30237 56041880
Purple glove syndrome 13.26 10.02 9 219941 204 56071913
Rectal cancer metastatic 13.25 10.02 10 219940 269 56071848
Gaze palsy 13.23 10.02 21 219929 1334 56070783
Alice in wonderland syndrome 13.13 10.02 5 219945 30 56072087
Injection site swelling 13.11 10.02 108 219842 43470 56028647
Product communication issue 13.11 10.02 12 219938 425 56071692
Gynaecomastia 13.07 10.02 8 219942 151 56071966
Seizure like phenomena 13.02 10.02 18 219932 1010 56071107
Parakeratosis 13.00 10.02 10 219940 277 56071840
Facet joint syndrome 12.96 10.02 5 219945 6712 56065405
Disinhibition 12.92 10.02 16 219934 805 56071312
Feeling of despair 12.90 10.02 27 219923 2126 56069991
Gait deviation 12.89 10.02 6 219944 63 56072054
Gastrointestinal toxicity 12.88 10.02 4 219946 6152 56065965
Subchorionic haemorrhage 12.75 10.02 8 219942 158 56071959
Ascites 12.73 10.02 90 219860 37454 56034663
Death of relative 12.71 10.02 9 219941 219 56071898
CSF glucose decreased 12.64 10.02 6 219944 66 56072051
Delusional perception 12.64 10.02 9 219941 221 56071896
Feeling drunk 12.61 10.02 38 219912 3754 56068363
Reduced facial expression 12.53 10.02 24 219926 1772 56070345
Tunnel vision 12.52 10.02 16 219934 831 56071286
Large intestine polyp 12.50 10.02 61 219889 7566 56064551
Chronic obstructive pulmonary disease 12.43 10.02 303 219647 57112 56015005
Decreased activity 12.41 10.02 49 219901 5547 56066570
Ventricular septal defect 12.40 10.02 40 219910 4098 56068019
Retching 12.40 10.02 93 219857 13437 56058680
Thirst 12.39 10.02 80 219870 11010 56061107
Pathogen resistance 12.37 10.02 4 219946 5996 56066121
Implant site irritation 12.36 10.02 8 219942 167 56071950
Skin reaction 12.31 10.02 20 219930 13043 56059074
Osteonecrosis of jaw 12.30 10.02 78 219872 33280 56038837
Sinus tachycardia 12.27 10.02 138 219812 22306 56049811
Serositis 12.26 10.02 14 219936 646 56071471
Trance 12.25 10.02 5 219945 37 56072080
Attention deficit hyperactivity disorder 12.24 10.02 30 219920 2624 56069493
Dry mouth 12.19 10.02 333 219617 63872 56008245
Neurological examination abnormal 12.19 10.02 9 219941 234 56071883
Glomerulonephritis minimal lesion 12.19 10.02 9 219941 234 56071883
Vanishing twin syndrome 12.18 10.02 7 219943 117 56072000
Hypoosmolar state 12.03 10.02 8 219942 175 56071942
Skin burning sensation 11.97 10.02 79 219871 10952 56061165
Temporomandibular joint syndrome 11.96 10.02 37 219913 3707 56068410
Meconium in amniotic fluid 11.96 10.02 9 219941 241 56071876
Negativism 11.96 10.02 11 219939 392 56071725
Pseudomonas infection 11.95 10.02 13 219937 10058 56062059
Bradycardia 11.95 10.02 347 219603 67157 56004960
Coma scale abnormal 11.95 10.02 44 219906 4819 56067298
Cytokine release syndrome 11.88 10.02 15 219935 10860 56061257
Trichotillomania 11.87 10.02 7 219943 123 56071994
Tubulointerstitial nephritis 11.87 10.02 30 219920 16635 56055482
Amnestic disorder 11.85 10.02 10 219940 317 56071800
Narcotic bowel syndrome 11.82 10.02 7 219943 124 56071993
Granulocytopenia neonatal 11.82 10.02 4 219946 16 56072101
Crime 11.82 10.02 4 219946 16 56072101
Tendonitis 11.82 10.02 34 219916 18063 56054054
Reflexes abnormal 11.74 10.02 13 219937 580 56071537
Congenital hydronephrosis 11.70 10.02 11 219939 403 56071714
Blood test abnormal 11.65 10.02 20 219930 12764 56059353
Atrial fibrillation 11.64 10.02 330 219620 108567 55963550
Right ventricular dilatation 11.64 10.02 18 219932 1118 56070999
Menopause 11.58 10.02 28 219922 2428 56069689
Boredom 11.58 10.02 3 219947 3 56072114
Dysphagia 11.58 10.02 410 219540 81537 55990580
Epilepsy 11.55 10.02 150 219800 25081 56047036
Staphylococcal scalded skin syndrome 11.53 10.02 7 219943 130 56071987
Female sexual dysfunction 11.50 10.02 5 219945 44 56072073
Proteinuria 11.48 10.02 33 219917 17537 56054580
Dyspraxia 11.47 10.02 9 219941 257 56071860
Muscle contractions involuntary 11.46 10.02 25 219925 2026 56070091
Antidepressant discontinuation syndrome 11.45 10.02 4 219946 18 56072099
Obsessive-compulsive personality disorder 11.45 10.02 4 219946 18 56072099
Myoclonic epilepsy 11.44 10.02 18 219932 1135 56070982
Orgasm abnormal 11.44 10.02 6 219944 83 56072034
Suspected suicide 11.43 10.02 47 219903 5419 56066698
Faeces discoloured 11.43 10.02 109 219841 16887 56055230
Polymenorrhagia 11.41 10.02 5 219945 45 56072072
Weight increased 11.40 10.02 1044 218906 228659 55843458
Drug-device interaction 11.37 10.02 6 219944 84 56072033
Pulmonary arterial hypertension 11.37 10.02 59 219891 26444 56045673
Facial paralysis 11.37 10.02 90 219860 13221 56058896
Dyspnoea exertional 11.34 10.02 148 219802 54541 56017576
Breath sounds abnormal 11.33 10.02 67 219883 8940 56063177
Myelodysplastic syndrome 11.33 10.02 30 219920 16376 56055741
Anticholinergic syndrome 11.29 10.02 24 219926 1910 56070207
Stupor 11.29 10.02 38 219912 3980 56068137
Serum serotonin decreased 11.27 10.02 4 219946 19 56072098
Generalised anxiety disorder 11.21 10.02 24 219926 1920 56070197
Hypoaesthesia eye 11.17 10.02 7 219943 138 56071979
Hyperuricaemia 11.16 10.02 3 219947 5070 56067047
Exposure via ingestion 11.15 10.02 30 219920 2778 56069339
Breast discomfort 11.14 10.02 11 219939 429 56071688
Genital hypoaesthesia 11.12 10.02 3 219947 4 56072113
Wound infection 11.09 10.02 27 219923 15166 56056951
Autoimmune myositis 11.07 10.02 6 219944 89 56072028
Pelvic inflammatory disease 11.06 10.02 21 219929 1540 56070577
Blood prolactin decreased 11.04 10.02 5 219945 49 56072068
Hostility 11.01 10.02 23 219927 1808 56070309
Lactate pyruvate ratio increased 11.01 10.02 6 219944 90 56072027
Headache 11.00 10.02 2406 217544 556638 55515479
Anal incontinence 10.97 10.02 84 219866 12214 56059903
Shared psychotic disorder 10.95 10.02 4 219946 21 56072096
Interstitial lung disease 10.90 10.02 157 219793 56906 56015211
Tumour lysis syndrome 10.84 10.02 9 219941 7914 56064203
Sensory disturbance 10.82 10.02 85 219865 12458 56059659
Body mass index increased 10.81 10.02 17 219933 1071 56071046
Coprolalia 10.79 10.02 4 219946 22 56072095
Fear of injection 10.79 10.02 6 219944 6509 56065608
Breast enlargement 10.78 10.02 20 219930 1441 56070676
Labour complication 10.78 10.02 6 219944 94 56072023
Dependence 10.77 10.02 24 219926 1973 56070144
Implant site rash 10.74 10.02 7 219943 148 56071969
Bone density decreased 10.70 10.02 21 219929 12739 56059378
Metastases to lymph nodes 10.70 10.02 8 219942 7415 56064702
Genital rash 10.69 10.02 11 219939 451 56071666
Disseminated intravascular coagulation 10.68 10.02 35 219915 17850 56054267
Polyarthritis 10.66 10.02 11 219939 8717 56063400
Wrong patient 10.66 10.02 7 219943 150 56071967
Deprescribing error 10.65 10.02 4 219946 23 56072094
Second primary malignancy 10.64 10.02 8 219942 7394 56064723
Live birth 10.62 10.02 40 219910 19565 56052552
Phalangeal agenesis 10.62 10.02 5 219945 54 56072063
Paralysis recurrent laryngeal nerve 10.62 10.02 5 219945 54 56072063
Fluid retention 10.61 10.02 148 219802 53930 56018187
Neonatal disorder 10.58 10.02 12 219938 550 56071567
Breast discharge 10.52 10.02 15 219935 866 56071251
Joint injury 10.51 10.02 58 219892 25596 56046521
Dislocation of vertebra 10.50 10.02 4 219946 5411 56066706
Cardiac septal defect 10.49 10.02 9 219941 292 56071825
Drug clearance decreased 10.48 10.02 19 219931 1345 56070772
Enuresis 10.44 10.02 26 219924 2297 56069820
Cardio-respiratory distress 10.42 10.02 7 219943 156 56071961
Jaundice cholestatic 10.42 10.02 46 219904 5473 56066644
Bladder cyst 10.37 10.02 3 219947 6 56072111
Pancreatic enzymes decreased 10.37 10.02 3 219947 6 56072111
Oral candidiasis 10.34 10.02 38 219912 18725 56053392
Gamma-glutamyltransferase abnormal 10.27 10.02 8 219942 226 56071891
Blood citric acid increased 10.23 10.02 5 219945 59 56072058
Mesenteric panniculitis 10.20 10.02 6 219944 105 56072012
Visual field defect 10.20 10.02 49 219901 6040 56066077
Loss of personal independence in daily activities 10.18 10.02 241 219709 81128 55990989
Blood pressure systolic abnormal 10.15 10.02 14 219936 9763 56062354
Arrested labour 10.15 10.02 8 219942 230 56071887
Dissociative amnesia 10.11 10.02 4 219946 27 56072090
Ocular discomfort 10.10 10.02 35 219915 3720 56068397
Heat exhaustion 10.10 10.02 6 219944 107 56072010
Polydipsia psychogenic 10.08 10.02 5 219945 61 56072056
Dependent personality disorder 10.08 10.02 5 219945 61 56072056
School refusal 10.06 10.02 3 219947 7 56072110
Movement disorder 10.03 10.02 117 219833 19081 56053036

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Depression 1142.32 10.75 1487 108431 89328 31498098
Serotonin syndrome 702.73 10.75 556 109362 18217 31569209
Drug interaction 601.58 10.75 1834 108084 206709 31380717
Suicidal ideation 564.17 10.75 663 109255 35743 31551683
Intentional self-injury 432.14 10.75 363 109555 12952 31574474
Anxiety 371.79 10.75 911 109007 90122 31497304
Suicide attempt 303.84 10.75 498 109420 36750 31550676
Intentional overdose 297.46 10.75 523 109395 40866 31546560
Completed suicide 287.50 10.75 831 109087 90683 31496743
Drug abuse 239.93 10.75 759 109159 86999 31500427
Agitation 202.95 10.75 525 109393 53644 31533782
Tremor 198.88 10.75 650 109268 75770 31511656
Aggression 190.47 10.75 408 109510 36883 31550543
Irritability 183.84 10.75 304 109614 22585 31564841
Pyrexia 180.85 10.75 502 109416 303338 31284088
Agitation neonatal 177.72 10.75 83 109835 1000 31586426
Foetal exposure during pregnancy 169.68 10.75 412 109506 40464 31546962
Paranoia 157.98 10.75 189 109729 10366 31577060
Obsessive-compulsive disorder 146.68 10.75 128 109790 4809 31582617
Maternal exposure during pregnancy 142.95 10.75 123 109795 4533 31582893
Somnolence 142.43 10.75 702 109216 98743 31488683
Priapism 133.69 10.75 118 109800 4502 31582924
Atrial septal defect 132.63 10.75 141 109777 6786 31580640
Respiratory disorder neonatal 127.93 10.75 74 109844 1421 31586005
Overdose 123.58 10.75 601 109317 84063 31503363
Febrile neutropenia 122.81 10.75 145 109773 121704 31465722
Dyskinesia 121.10 10.75 241 109677 20669 31566757
Sopor 120.23 10.75 173 109745 11379 31576047
Erectile dysfunction 117.83 10.75 227 109691 19008 31568418
Withdrawal syndrome 116.90 10.75 172 109746 11545 31575881
Toxicity to various agents 114.03 10.75 1043 108875 180444 31406982
Acute kidney injury 112.78 10.75 543 109375 279171 31308255
Confusional state 112.19 10.75 819 109099 132515 31454911
Parkinsonism 109.81 10.75 134 109784 7502 31579924
Psychotic disorder 109.31 10.75 240 109678 22053 31565373
Loss of personal independence in daily activities 107.75 10.75 276 109642 28012 31559414
Drug withdrawal syndrome neonatal 106.70 10.75 92 109826 3400 31584026
Hallucination, auditory 104.68 10.75 153 109765 10207 31577219
Anger 103.11 10.75 158 109760 10995 31576431
Sexual dysfunction 101.25 10.75 114 109804 5854 31581572
Pneumonia 100.51 10.75 716 109202 334596 31252830
Off label use 97.20 10.75 756 109162 346518 31240908
Loss of libido 96.18 10.75 74 109844 2321 31585105
Delusion 93.17 10.75 157 109761 11840 31575586
Blepharospasm 92.89 10.75 54 109864 1047 31586379
Drug withdrawal syndrome 89.83 10.75 200 109718 18550 31568876
Malignant neoplasm progression 88.47 10.75 86 109832 78912 31508514
Sepsis 87.88 10.75 254 109664 151675 31435751
Exposure during pregnancy 86.90 10.75 127 109791 8471 31578955
Intrusive thoughts 86.60 10.75 34 109884 257 31587169
Akathisia 86.52 10.75 116 109802 7137 31580289
Insomnia 86.38 10.75 594 109324 94242 31493184
Tachyphrenia 85.34 10.75 53 109865 1164 31586262
Homicidal ideation 84.77 10.75 71 109847 2520 31584906
Restlessness 83.91 10.75 223 109695 23138 31564288
Extrapyramidal disorder 82.16 10.75 147 109771 11631 31575795
Anaemia 81.64 10.75 422 109496 213100 31374326
Pancytopenia 80.57 10.75 111 109807 87205 31500221
Major depression 78.65 10.75 85 109833 4168 31583258
Mania 77.88 10.75 125 109793 9052 31578374
Hallucination 76.13 10.75 341 109577 46069 31541357
Dystonia 75.70 10.75 131 109787 10094 31577332
Mood swings 75.53 10.75 110 109808 7314 31580112
Catatonia 75 10.75 88 109830 4726 31582700
Neutropenia 74.52 10.75 244 109674 140120 31447306
Derealisation 72.47 10.75 37 109881 548 31586878
Thrombocytopenia 72.47 10.75 253 109665 142494 31444932
Anorgasmia 72.43 10.75 40 109878 700 31586726
Sedation 71.14 10.75 184 109734 18781 31568645
Abnormal behaviour 70.46 10.75 212 109706 23616 31563810
Obsessive thoughts 69.17 10.75 37 109881 606 31586820
Renal impairment 68.94 10.75 121 109797 86228 31501198
Hypomania 68.52 10.75 59 109859 2176 31585250
Hallucination, visual 67.42 10.75 161 109757 15633 31571793
Hypertonia neonatal 66.98 10.75 32 109886 407 31587019
Rheumatoid arthritis 66.19 10.75 42 109876 47767 31539659
Amnesia 63.43 10.75 202 109716 23200 31564226
Neuroleptic malignant syndrome 62.59 10.75 163 109755 16706 31570720
Disease progression 60.89 10.75 140 109778 90324 31497102
Feeling jittery 60.44 10.75 70 109848 3707 31583719
Bradykinesia 59.89 10.75 68 109850 3524 31583902
Treatment noncompliance 57.55 10.75 208 109710 25476 31561950
Depressive symptom 57.22 10.75 52 109866 2062 31585364
Nightmare 56.49 10.75 128 109790 12009 31575417
Bradyphrenia 56.49 10.75 73 109845 4331 31583095
Rash 56.46 10.75 438 109480 201048 31386378
Cytomegalovirus infection 56.42 10.75 9 109909 24698 31562728
Septic shock 56.23 10.75 89 109829 66069 31521357
Neuropathy peripheral 54.26 10.75 113 109805 75536 31511890
Disturbance in attention 53.90 10.75 186 109732 22264 31565162
Prostate cancer 53.48 10.75 32 109886 37569 31549857
Tearfulness 53.33 10.75 48 109870 1879 31585547
Hyperhidrosis 53.19 10.75 408 109510 66985 31520441
Large for dates baby 53.08 10.75 35 109883 855 31586571
Head discomfort 52.76 10.75 65 109853 3674 31583752
Patent ductus arteriosus 52.48 10.75 60 109858 3133 31584293
General physical health deterioration 52.35 10.75 209 109709 113226 31474200
Colitis microscopic 51.60 10.75 48 109870 1962 31585464
Neonatal respiratory distress syndrome 50.78 10.75 65 109853 3820 31583606
Infusion related reaction 50.73 10.75 55 109863 48000 31539426
Blood prolactin increased 50.05 10.75 43 109875 1581 31585845
Genital hypoaesthesia 49.38 10.75 21 109897 199 31587227
Homicide 49.25 10.75 34 109884 898 31586528
Fall 49.11 10.75 912 109006 185177 31402249
Pleural effusion 48.76 10.75 118 109800 74802 31512624
Social avoidant behaviour 48.48 10.75 56 109862 2957 31584469
Psychiatric decompensation 48.45 10.75 46 109872 1930 31585496
Feeling abnormal 48.32 10.75 351 109567 56651 31530775
Apathy 47.92 10.75 83 109835 6399 31581027
Bruxism 47.89 10.75 42 109876 1588 31585838
Tic 47.63 10.75 45 109873 1876 31585550
Interstitial lung disease 47.24 10.75 88 109830 61315 31526111
Depressed mood 46.99 10.75 151 109767 17424 31570002
Seizure 46.56 10.75 540 109378 99228 31488198
Thinking abnormal 46.04 10.75 75 109843 5498 31581928
Maternal exposure during breast feeding 45.69 10.75 40 109878 1509 31585917
Ascites 45.48 10.75 45 109873 40968 31546458
Panic attack 45.29 10.75 96 109822 8607 31578819
Cardiac failure 45.16 10.75 150 109768 85803 31501623
Platelet count decreased 43.97 10.75 215 109703 110220 31477206
Haemangioma congenital 43.50 10.75 25 109893 474 31586952
Sleep disorder 43.49 10.75 194 109724 26154 31561272
Affective disorder 43.41 10.75 59 109859 3677 31583749
Cogwheel rigidity 43.31 10.75 36 109882 1264 31586162
Dyspnoea 43.05 10.75 887 109031 342592 31244834
Libido decreased 42.63 10.75 64 109854 4372 31583054
Ventricular septal defect 42.62 10.75 58 109860 3619 31583807
Oromandibular dystonia 41.43 10.75 24 109894 462 31586964
Muscle rigidity 41.28 10.75 100 109818 9797 31577629
Psychomotor hyperactivity 41.26 10.75 93 109825 8694 31578732
Bone marrow failure 41.02 10.75 23 109895 27985 31559441
Renal failure 40.95 10.75 255 109663 123075 31464351
Pneumocystis jirovecii pneumonia 40.89 10.75 7 109911 18244 31569182
Fever neonatal 40.83 10.75 10 109908 8 31587418
Bipolar disorder 40.55 10.75 57 109861 3667 31583759
Electrocardiogram QT prolonged 40.06 10.75 247 109671 37740 31549686
Plasma cell myeloma 40.06 10.75 85 109833 56446 31530980
Oesophageal pain 39.60 10.75 28 109890 769 31586657
Resting tremor 39.26 10.75 26 109892 640 31586786
Mucosal inflammation 39.07 10.75 37 109881 34390 31553036
Product substitution issue 39.02 10.75 95 109823 9337 31578089
Diarrhoea 39.02 10.75 928 108990 351481 31235945
Restless legs syndrome 38.57 10.75 84 109834 7672 31579754
Muscle twitching 38.53 10.75 87 109831 8143 31579283
Prescribed overdose 38.47 10.75 93 109825 9099 31578327
Erythema 38.45 10.75 146 109772 80259 31507167
Depression suicidal 37.98 10.75 37 109881 1603 31585823
Antidepressant drug level increased 37.91 10.75 15 109903 116 31587310
Hyponatraemia 37.85 10.75 407 109511 73392 31514034
Apgar score low 37.58 10.75 28 109890 836 31586590
Speech disorder 37.57 10.75 175 109743 24026 31563400
Arthralgia 37.48 10.75 340 109578 151084 31436342
Anhedonia 37.47 10.75 81 109837 7361 31580065
Depersonalisation/derealisation disorder 37.29 10.75 24 109894 562 31586864
Blood creatine phosphokinase increased 37.03 10.75 261 109657 41713 31545713
Loss of consciousness 36.66 10.75 420 109498 76935 31510491
Persecutory delusion 36.65 10.75 43 109875 2309 31585117
Hepatic function abnormal 36.42 10.75 54 109864 41168 31546258
Antipsychotic drug level increased 36.29 10.75 52 109866 3406 31584020
Ejaculation failure 35.82 10.75 26 109892 745 31586681
Stomatitis 35.49 10.75 51 109867 39387 31548039
C-reactive protein increased 35.44 10.75 72 109846 48578 31538848
Overweight 35.31 10.75 35 109883 1549 31585877
Premature ejaculation 34.87 10.75 14 109904 113 31587313
Morose 34.81 10.75 8 109910 3 31587423
Foaming at mouth 34.54 10.75 25 109893 713 31586713
Myoclonus 34.53 10.75 117 109801 13873 31573553
Pressure of speech 34.31 10.75 21 109897 449 31586977
Tumour lysis syndrome 34.25 10.75 6 109912 15379 31572047
Small for dates baby 34.09 10.75 52 109866 3603 31583823
Ideas of reference 33.99 10.75 11 109907 43 31587383
Infantile apnoea 33.50 10.75 27 109891 907 31586519
Semen discolouration 33.23 10.75 9 109909 15 31587411
Death 32.68 10.75 977 108941 359592 31227834
Dysphoria 32.67 10.75 39 109879 2133 31585293
Platelet aggregation abnormal 32.52 10.75 9 109909 17 31587409
Parkinsonism hyperpyrexia syndrome 32.37 10.75 12 109906 76 31587350
Pneumonitis 31.34 10.75 36 109882 30616 31556810
Delusion of replacement 31.25 10.75 13 109905 116 31587310
Personality change 31.10 10.75 58 109860 4737 31582689
Bradycardia neonatal 31.01 10.75 26 109892 924 31586502
Persistent depressive disorder 30.96 10.75 17 109901 294 31587132
Generalised tonic-clonic seizure 30.84 10.75 144 109774 19787 31567639
Male sexual dysfunction 30.75 10.75 16 109902 247 31587179
Myelosuppression 30.75 10.75 7 109911 14913 31572513
Blood creatinine increased 30.69 10.75 182 109736 88896 31498530
Drug screen positive 30.69 10.75 51 109867 3801 31583625
Muscle strain 30.68 10.75 50 109868 3667 31583759
Meconium aspiration syndrome 30.34 10.75 10 109908 42 31587384
Middle insomnia 30.27 10.75 66 109852 6033 31581393
Acute psychosis 30.17 10.75 34 109884 1747 31585679
Multiple organ dysfunction syndrome 29.98 10.75 128 109790 68075 31519351
Hyporesponsive to stimuli 29.90 10.75 26 109892 972 31586454
Psychomotor skills impaired 29.89 10.75 45 109873 3082 31584344
White blood cell count decreased 29.88 10.75 179 109739 87219 31500207
Tremor neonatal 29.82 10.75 18 109900 375 31587051
Trismus 29.50 10.75 39 109879 2366 31585060
Torticollis 29.41 10.75 27 109891 1085 31586341
Neonatal respiratory distress 29.28 10.75 20 109898 519 31586907
COVID-19 29.25 10.75 95 109823 54726 31532700
Suicidal behaviour 28.93 10.75 30 109888 1402 31586024
Nasopharyngitis 28.85 10.75 117 109801 63128 31524298
Lymphadenopathy 28.57 10.75 29 109889 26092 31561334
Generalised anxiety disorder 28.51 10.75 22 109896 693 31586733
Drug level increased 28.47 10.75 142 109776 20044 31567382
Urticaria 28.43 10.75 103 109815 57414 31530012
Dermatillomania 28.30 10.75 10 109908 54 31587372
Neonatal respiratory acidosis 28.15 10.75 10 109908 55 31587371
Bipolar I disorder 28.07 10.75 23 109895 791 31586635
Left ventricular false tendon 28.01 10.75 6 109912 0 31587426
Basal cell carcinoma 27.99 10.75 14 109904 18165 31569261
Myelodysplastic syndrome 27.91 10.75 16 109902 19235 31568191
Drug dependence 27.82 10.75 153 109765 22426 31565000
Grandiosity 27.62 10.75 16 109902 308 31587118
Negativism 27.51 10.75 17 109901 370 31587056
Dissociation 27.43 10.75 28 109890 1284 31586142
Neonatal behavioural syndrome 27.31 10.75 12 109906 124 31587302
Neutrophil count decreased 27.18 10.75 77 109841 46317 31541109
Cytokine release syndrome 26.87 10.75 12 109906 16630 31570796
Dementia with Lewy bodies 26.85 10.75 21 109897 675 31586751
Neonatal respiratory arrest 26.84 10.75 8 109910 22 31587404
Drug reaction with eosinophilia and systemic symptoms 26.83 10.75 39 109879 29979 31557447
Mental disorder 26.82 10.75 107 109811 13727 31573699
Persistent foetal circulation 26.69 10.75 16 109902 329 31587097
Agitated depression 26.46 10.75 14 109904 224 31587202
Leukopenia 26.36 10.75 107 109811 57721 31529705
Maternal drugs affecting foetus 26.31 10.75 48 109870 3855 31583571
Tardive dyskinesia 26.28 10.75 59 109859 5500 31581926
Anorectal discomfort 26.12 10.75 31 109887 1685 31585741
Disorientation 25.86 10.75 189 109729 30555 31556871
Atrial fibrillation 25.79 10.75 261 109657 113522 31473904
Graft versus host disease 25.76 10.75 3 109915 10444 31576982
Alcoholism 25.75 10.75 44 109874 3355 31584071
Haemoglobin decreased 25.73 10.75 258 109660 112417 31475009
Phospholipidosis 25.72 10.75 9 109909 47 31587379
Exposure via breast milk 25.71 10.75 32 109886 1828 31585598
Dystonic tremor 25.49 10.75 13 109905 192 31587234
Inflammation 25.42 10.75 30 109888 25211 31562215
Gastrointestinal motility disorder 25.33 10.75 36 109882 2340 31585086
Self esteem decreased 25.31 10.75 18 109900 499 31586927
Impulsive behaviour 25.25 10.75 33 109885 1980 31585446
Bronchopulmonary aspergillosis 25.07 10.75 8 109910 13626 31573800
Macrophages increased 24.42 10.75 12 109906 163 31587263
Prader-Willi syndrome 24.40 10.75 7 109911 16 31587410
Peripheral swelling 24.26 10.75 137 109781 67728 31519698
Radiologically isolated syndrome 23.87 10.75 6 109912 6 31587420
Orthostatic hypotension 23.67 10.75 154 109764 23965 31563461
Oedema peripheral 23.65 10.75 255 109663 109584 31477842
Attention deficit hyperactivity disorder 23.62 10.75 35 109883 2363 31585063
Hyperkalaemia 23.50 10.75 129 109789 64222 31523204
Neonatal anoxia 23.34 10.75 5 109913 0 31587426
Psychomotor retardation 23.20 10.75 41 109877 3211 31584215
Psoriatic arthropathy 22.99 10.75 21 109897 19862 31567564
Maternal exposure timing unspecified 22.98 10.75 15 109903 360 31587066
Mydriasis 22.97 10.75 62 109856 6490 31580936
Balance disorder 22.85 10.75 214 109704 37208 31550218
Newborn persistent pulmonary hypertension 22.70 10.75 10 109908 104 31587322
Treatment failure 22.24 10.75 70 109848 40722 31546704
Hypotonia neonatal 22.19 10.75 25 109893 1284 31586142
Weight decrease neonatal 22.01 10.75 14 109904 321 31587105
Infection 22.01 10.75 180 109738 81751 31505675
Cognitive disorder 21.99 10.75 155 109763 24768 31562658
Unmasking of previously unidentified disease 21.99 10.75 20 109898 794 31586632
Negative thoughts 21.92 10.75 18 109900 621 31586805
Acute respiratory distress syndrome 21.81 10.75 32 109886 24508 31562918
Hepatic enzyme increased 21.47 10.75 59 109859 35849 31551577
Post concussion syndrome 21.44 10.75 10 109908 120 31587306
Excessive masturbation 21.28 10.75 9 109909 84 31587342
Acute myeloid leukaemia 21.26 10.75 20 109898 18652 31568774
Orgasm abnormal 21.23 10.75 10 109908 123 31587303
Synovitis 21.22 10.75 8 109910 12275 31575151
Hepatotoxicity 21.18 10.75 21 109897 19105 31568321
Hyperprolactinaemia 21.17 10.75 26 109892 1465 31585961
Transplant rejection 21.15 10.75 4 109914 9704 31577722
Reflux laryngitis 21.14 10.75 6 109912 13 31587413
Product complaint 21.13 10.75 54 109864 5470 31581956
Alcohol interaction 20.99 10.75 36 109882 2753 31584673
Rapid eye movements sleep abnormal 20.90 10.75 11 109907 174 31587252
Aspergillus infection 20.78 10.75 7 109911 11521 31575905
Mood altered 20.77 10.75 70 109848 8276 31579150
Oesophageal ulcer haemorrhage 20.68 10.75 11 109907 178 31587248
Parasomnia 20.67 10.75 14 109904 358 31587068
Pulmonary artery stenosis 20.67 10.75 12 109906 232 31587194
Obsessive-compulsive symptom 20.67 10.75 10 109908 131 31587295
Urinary hesitation 20.57 10.75 33 109885 2388 31585038
Respiratory failure 20.46 10.75 239 109679 101210 31486216
Poisoning deliberate 20.45 10.75 64 109854 7280 31580146
Drug resistance 20.44 10.75 31 109887 23422 31564004
Inappropriate antidiuretic hormone secretion 20.44 10.75 86 109832 11301 31576125
Tongue biting 20.44 10.75 19 109899 776 31586650
Haemorrhagic hepatic cyst 20.27 10.75 6 109912 16 31587410
Cardiogenic shock 20.13 10.75 29 109889 22379 31565047
Joint swelling 20.12 10.75 106 109812 53325 31534101
Gout 20.08 10.75 20 109898 18154 31569272
Congenital hydronephrosis 20.08 10.75 18 109900 701 31586725
Implant site extravasation 20.01 10.75 14 109904 378 31587048
Sedation complication 20.00 10.75 25 109893 1434 31585992
Congenital megaureter 19.90 10.75 10 109908 143 31587283
Male orgasmic disorder 19.83 10.75 9 109909 101 31587325
Hypertonia 19.76 10.75 43 109875 3925 31583501
Tubulointerstitial nephritis 19.70 10.75 21 109897 18475 31568951
Cerebral haemorrhage neonatal 19.67 10.75 12 109906 255 31587171
Pain in extremity 19.66 10.75 284 109634 115919 31471507
Influenza 19.59 10.75 83 109835 44242 31543184
Cryptorchism 19.57 10.75 29 109889 1958 31585468
Haemophagocytic lymphohistiocytosis 19.53 10.75 8 109910 11670 31575756
Schizophreniform disorder 19.47 10.75 8 109910 69 31587357
Chronic kidney disease 19.43 10.75 67 109851 37908 31549518
Tongue injury 19.37 10.75 9 109909 107 31587319
Cerebral infarction 19.30 10.75 38 109880 25939 31561487
Sexual activity increased 19.28 10.75 6 109912 20 31587406
Social anxiety disorder 19.18 10.75 12 109906 267 31587159
Haemoptysis 19.16 10.75 53 109865 32136 31555290
Muscle tightness 19.14 10.75 46 109872 4483 31582943
Periodic limb movement disorder 19.01 10.75 9 109909 112 31587314
Euphoric mood 18.72 10.75 48 109870 4872 31582554
Arthritis 18.71 10.75 42 109876 27343 31560083
Polyneuropathy 18.63 10.75 11 109907 13011 31574415
Nephropathy toxic 18.63 10.75 8 109910 11345 31576081
Foetal growth restriction 18.61 10.75 41 109877 3774 31583652
Violence-related symptom 18.53 10.75 15 109903 507 31586919
Therapeutic response unexpected 18.47 10.75 71 109847 8953 31578473
High-pitched crying 18.22 10.75 5 109913 9 31587417
Abulia 18.13 10.75 15 109903 523 31586903
Pruritus 18.13 10.75 315 109603 124852 31462574
Nervousness 18.07 10.75 85 109833 11715 31575711
Memory impairment 18.03 10.75 207 109711 37923 31549503
Dysphemia 17.98 10.75 24 109894 1470 31585956
Acute myocardial infarction 17.94 10.75 103 109815 50720 31536706
Disturbance in sexual arousal 17.83 10.75 9 109909 130 31587296
Confabulation 17.83 10.75 9 109909 130 31587296
Congenital pulmonary valve atresia 17.82 10.75 7 109911 53 31587373
Libido increased 17.79 10.75 17 109901 719 31586707
Ejaculation delayed 17.73 10.75 11 109907 241 31587185
Strabismus congenital 17.70 10.75 6 109912 28 31587398
Crying 17.68 10.75 51 109867 5546 31581880
Cellulitis 17.67 10.75 96 109822 47922 31539504
Apallic syndrome 17.65 10.75 11 109907 243 31587183
Loose associations 17.60 10.75 7 109911 55 31587371
Libido disorder 17.58 10.75 11 109907 245 31587181
Enuresis 17.51 10.75 29 109889 2155 31585271
Lymphomatoid papulosis 17.38 10.75 10 109908 190 31587236
Schizophrenia 17.31 10.75 79 109839 10751 31576675
Blood bilirubin increased 17.30 10.75 63 109855 35073 31552353
Action tremor 17.28 10.75 7 109911 58 31587368
Blood ethanol increased 17.20 10.75 14 109904 477 31586949
Rash maculo-papular 17.12 10.75 40 109878 25679 31561747
Blood pressure fluctuation 17.11 10.75 33 109885 22703 31564723
Coma 17.11 10.75 218 109700 40932 31546494
Intentional product misuse 17.05 10.75 204 109714 37747 31549679
Psychotic symptom 17.03 10.75 24 109894 1548 31585878
Coloboma 17.01 10.75 9 109909 144 31587282
Ejaculation disorder 16.94 10.75 19 109899 971 31586455
Physical assault 16.93 10.75 20 109898 1082 31586344
Granulocytopenia 16.84 10.75 53 109865 6046 31581380
Migraine 16.74 10.75 95 109823 14085 31573341
Alveolar bone resorption 16.71 10.75 5 109913 14 31587412
Blood cholesterol increased 16.66 10.75 108 109810 16785 31570641
Alcohol poisoning 16.52 10.75 35 109883 3136 31584290
Gastrooesophageal reflux disease 16.52 10.75 185 109733 33686 31553740
Drug intolerance 16.52 10.75 109 109809 51924 31535502
Septum pellucidum agenesis 16.49 10.75 7 109911 66 31587360
Neonatal disorder 16.49 10.75 17 109901 789 31586637
Hypocalcaemia 16.45 10.75 32 109886 21946 31565480
Weight increased 16.42 10.75 390 109528 82557 31504869
Grunting 16.41 10.75 12 109906 348 31587078
Medication error 16.37 10.75 135 109783 22637 31564789
Hyperuricaemia 16.34 10.75 3 109915 7435 31579991
Obesity 16.30 10.75 79 109839 11021 31576405
Hypersomnia 16.23 10.75 79 109839 11040 31576386
Cytopenia 16.18 10.75 9 109909 11001 31576425
Liver disorder 16.17 10.75 51 109867 29656 31557770
Impaired work ability 16.17 10.75 51 109867 5826 31581600
Pharyngeal dystonia 16.13 10.75 7 109911 70 31587356
Dysarthria 16.13 10.75 176 109742 31841 31555585
Hypoglycaemia neonatal 16.12 10.75 25 109893 1757 31585669
Palmar-plantar erythrodysaesthesia syndrome 16.03 10.75 18 109900 15465 31571961
Diffuse large B-cell lymphoma 16.02 10.75 5 109913 8636 31578790
Blood triglycerides increased 15.98 10.75 90 109828 13307 31574119
Drug eruption 15.89 10.75 24 109894 18163 31569263
Colitis 15.88 10.75 62 109856 33825 31553601
Lung disorder 15.87 10.75 58 109860 32254 31555172
Kidney transplant rejection 15.86 10.75 3 109915 7279 31580147
Respiratory dyskinesia 15.77 10.75 5 109913 18 31587408
Painful erection 15.77 10.75 10 109908 228 31587198
Cardiac failure acute 15.77 10.75 7 109911 9734 31577692
Metabolic acidosis 15.76 10.75 77 109841 39500 31547926
Transient tachypnoea of the newborn 15.74 10.75 9 109909 169 31587257
Gastrointestinal haemorrhage 15.68 10.75 197 109721 82352 31505074
Tongue spasm 15.56 10.75 6 109912 43 31587383
Product use in unapproved indication 15.53 10.75 246 109672 98925 31488501
Post-traumatic stress disorder 15.50 10.75 24 109894 1685 31585741
Compulsive sexual behaviour 15.47 10.75 10 109908 236 31587190
Illusion 15.46 10.75 16 109902 746 31586680
Urinary incontinence 15.44 10.75 108 109810 17212 31570214
Paraneoplastic rash 15.31 10.75 7 109911 80 31587346
Transaminases increased 15.31 10.75 39 109879 24302 31563124
Panic disorder 15.27 10.75 20 109898 1202 31586224
Malpositioned teeth 15.17 10.75 5 109913 21 31587405
Muscle contractions involuntary 15.13 10.75 24 109894 1720 31585706
COVID-19 pneumonia 15.07 10.75 13 109905 12642 31574784
Hypotension 15.04 10.75 569 109349 204049 31383377
Obsessive rumination 15.03 10.75 4 109914 6 31587420
Fungal infection 14.97 10.75 17 109901 14534 31572892
Panic reaction 14.94 10.75 21 109897 1351 31586075
Intraventricular haemorrhage neonatal 14.86 10.75 10 109908 253 31587173
Emotional disorder 14.85 10.75 46 109872 5203 31582223
Hypoalbuminaemia 14.83 10.75 10 109908 11018 31576408
Dissociative identity disorder 14.81 10.75 5 109913 23 31587403
Gangrene neonatal 14.72 10.75 9 109909 192 31587234
Pulmonary embolism 14.71 10.75 197 109721 81449 31505977
Onychomycosis 14.70 10.75 27 109891 2179 31585247
Abdominal distension 14.70 10.75 109 109809 50575 31536851
Posture abnormal 14.70 10.75 26 109892 2038 31585388
Drug screen false positive 14.69 10.75 15 109903 688 31586738
Hepatocellular carcinoma 14.64 10.75 6 109912 8750 31578676
Anuria 14.45 10.75 8 109910 9806 31577620
Activation syndrome 14.45 10.75 7 109911 92 31587334
Hypersexuality 14.41 10.75 21 109897 1397 31586029
Psychiatric symptom 14.40 10.75 34 109884 3277 31584149
Feelings of worthlessness 14.36 10.75 10 109908 268 31587158
Temperature regulation disorder 14.34 10.75 14 109904 608 31586818
Pneumonia bacterial 14.31 10.75 9 109909 10287 31577139
Pulmonary microemboli 14.30 10.75 4 109914 8 31587418
Congenital hearing disorder 14.25 10.75 7 109911 95 31587331
Hippocampal sclerosis 14.19 10.75 7 109911 96 31587330
Cytomegalovirus viraemia 14.17 10.75 3 109915 6722 31580704
Cardiac failure congestive 14.14 10.75 192 109726 79195 31508231
Hypomagnesaemia 14.05 10.75 28 109890 19030 31568396
Arthropathy 14.02 10.75 40 109878 24011 31563415
Arterial ligation 14.00 10.75 3 109915 0 31587426
Enteric neuropathy 14.00 10.75 3 109915 0 31587426
Nasal cavity packing 14.00 10.75 3 109915 0 31587426
Foetal damage 14.00 10.75 3 109915 0 31587426
Constricted affect 14.00 10.75 3 109915 0 31587426
Red blood cell elliptocytes present 13.93 10.75 7 109911 100 31587326
Deep vein thrombosis 13.88 10.75 139 109779 60597 31526829
Enterocolitis 13.86 10.75 4 109914 7270 31580156
Proteinuria 13.81 10.75 23 109895 16740 31570686
Sneezing 13.74 10.75 42 109876 4717 31582709
Transposition of the great vessels 13.70 10.75 12 109906 453 31586973
Genital anaesthesia 13.70 10.75 4 109914 10 31587416
Bladder dilatation 13.66 10.75 20 109898 1336 31586090
Dysgraphia 13.65 10.75 26 109892 2157 31585269
Blood urea increased 13.65 10.75 53 109865 28959 31558467
Peritonitis 13.61 10.75 20 109898 15307 31572119
Hallucinations, mixed 13.56 10.75 28 109890 2464 31584962
Duplicate therapy error 13.54 10.75 8 109910 160 31587266
Rebound psychosis 13.54 10.75 8 109910 160 31587266
Suspected suicide 13.54 10.75 38 109880 4069 31583357
Poor feeding infant 13.50 10.75 12 109906 462 31586964
Cataract congenital 13.49 10.75 6 109912 64 31587362
Delirium 13.42 10.75 210 109708 41211 31546215
Drug dispensed to wrong patient 13.39 10.75 12 109906 467 31586959
Hepatitis 13.38 10.75 36 109882 22030 31565396
Hepatic failure 13.38 10.75 63 109855 32639 31554787
Salivary hypersecretion 13.33 10.75 58 109860 7734 31579692
Anaphylactic reaction 13.26 10.75 55 109863 29498 31557928
Spasmodic dysphonia 13.24 10.75 8 109910 167 31587259
Illness anxiety disorder 13.24 10.75 8 109910 167 31587259
Thrombotic microangiopathy 13.23 10.75 8 109910 9343 31578083
Poverty of thought content 13.19 10.75 5 109913 34 31587392
Somnambulism 13.18 10.75 30 109888 2822 31584604
Skin indentation 13.17 10.75 4 109914 12 31587414
Second primary malignancy 13.16 10.75 4 109914 7028 31580398
Maculopathy 13.12 10.75 16 109902 895 31586531
Immune reconstitution inflammatory syndrome 13.04 10.75 6 109912 8172 31579254
Dyspnoea exertional 13.02 10.75 80 109838 38757 31548669
Abnormal dreams 13.00 10.75 54 109864 7054 31580372
Product dispensing error 12.99 10.75 47 109871 5757 31581669
Intentional product use issue 12.98 10.75 109 109809 49238 31538188
Emotional poverty 12.97 10.75 12 109906 487 31586939
Contraindicated product administered 12.96 10.75 31 109887 19741 31567685
Selective mutism 12.94 10.75 6 109912 71 31587355
Self-medication 12.93 10.75 26 109892 2245 31585181
Vascular dementia 12.93 10.75 12 109906 489 31586937
Device related infection 12.85 10.75 23 109895 16276 31571150
Dementia 12.79 10.75 80 109838 12280 31575146
Optic ischaemic neuropathy 12.76 10.75 24 109894 1973 31585453
Anxiety disorder due to a general medical condition 12.70 10.75 4 109914 14 31587412
Product communication issue 12.69 10.75 10 109908 325 31587101
Oxygen saturation decreased 12.69 10.75 109 109809 49006 31538420
Pancreatic carcinoma 12.68 10.75 7 109911 8593 31578833
Brugada syndrome 12.67 10.75 14 109904 704 31586722
Osteonecrosis of jaw 12.65 10.75 25 109893 17046 31570380
Renal injury 12.65 10.75 11 109907 10654 31576772
Oesophageal carcinoma 12.65 10.75 6 109912 8027 31579399
Self-injurious ideation 12.63 10.75 21 109897 1566 31585860
Sinusitis 12.61 10.75 75 109843 36621 31550805
Daydreaming 12.61 10.75 12 109906 505 31586921
Lithiasis 12.60 10.75 5 109913 39 31587387
Fallot's tetralogy 12.59 10.75 8 109910 183 31587243
Pericardial effusion 12.56 10.75 38 109880 22385 31565041
Localised infection 12.52 10.75 21 109897 15244 31572182
Cholangitis 12.52 10.75 6 109912 7980 31579446
Product use issue 12.51 10.75 131 109787 56628 31530798
Diffuse vasculitis 12.51 10.75 6 109912 77 31587349
Pregnancy 12.46 10.75 9 109909 256 31587170
Hepatocellular injury 12.43 10.75 36 109882 21508 31565918
Alanine aminotransferase increased 12.43 10.75 183 109735 74473 31512953
Decreased interest 12.42 10.75 25 109893 2160 31585266
Premature baby 12.40 10.75 106 109812 17960 31569466
Feeling drunk 12.40 10.75 22 109896 1729 31585697
Pulmonary alveolar haemorrhage 12.39 10.75 4 109914 6762 31580664
Umbilical cord abnormality 12.39 10.75 5 109913 41 31587385
Stoma site infection 12.35 10.75 14 109904 724 31586702
Herpes zoster 12.30 10.75 63 109855 31930 31555496
Gun shot wound 12.29 10.75 17 109901 1077 31586349
Sleep inertia 12.29 10.75 4 109914 16 31587410
Cough 12.21 10.75 365 109553 134449 31452977
Colitis ulcerative 12.19 10.75 29 109889 18500 31568926
Respiratory arrest 12.17 10.75 142 109776 26115 31561311
Mixed dementia 12.10 10.75 9 109909 268 31587158
Urinary retention 12.10 10.75 174 109744 33551 31553875
Hepatorenal failure 12.09 10.75 12 109906 532 31586894
Disseminated intravascular coagulation 12.09 10.75 34 109884 20503 31566923
Moaning 12.06 10.75 14 109904 743 31586683
Genital blister 11.93 10.75 3 109915 3 31587423
Colostomy infection 11.93 10.75 3 109915 3 31587423
Congenital gastric anomaly 11.93 10.75 3 109915 3 31587423
Abdominoplasty 11.93 10.75 3 109915 3 31587423
Wrong patient received product 11.92 10.75 27 109891 2532 31584894
Bankruptcy 11.91 10.75 4 109914 18 31587408
Abdominal pain 11.81 10.75 401 109517 145551 31441875
Personality disorder 11.79 10.75 17 109901 1120 31586306
Haemolytic anaemia 11.74 10.75 10 109908 9786 31577640
Platelet aggregation decreased 11.74 10.75 4 109914 19 31587407
Velopharyngeal incompetence 11.74 10.75 4 109914 19 31587407
Rash pruritic 11.73 10.75 43 109875 23895 31563531
Hyperbilirubinaemia 11.73 10.75 23 109895 15727 31571699
Drug tolerance increased 11.71 10.75 11 109907 455 31586971
Aphasia 11.68 10.75 113 109805 19818 31567608
Flashback 11.63 10.75 7 109911 145 31587281
Skin turgor decreased 11.59 10.75 11 109907 461 31586965
Food interaction 11.58 10.75 15 109903 892 31586534
Pathogen resistance 11.56 10.75 8 109910 8693 31578733
Progressive multifocal leukoencephalopathy 11.55 10.75 9 109909 9204 31578222
Mallory-Weiss syndrome 11.53 10.75 18 109900 1272 31586154
Tension 11.50 10.75 23 109895 1978 31585448
Dyskinesia neonatal 11.48 10.75 3 109915 4 31587422
Shock haemorrhagic 11.47 10.75 11 109907 10166 31577260
Foetal death 11.47 10.75 8 109910 215 31587211
Drug dose titration not performed 11.43 10.75 9 109909 292 31587134
Vesicoureteric reflux 11.42 10.75 7 109911 150 31587276
Facial discomfort 11.41 10.75 4 109914 21 31587405
Anal abscess 11.41 10.75 3 109915 5797 31581629
Rales 11.40 10.75 8 109910 8631 31578795
Affect lability 11.36 10.75 32 109886 3433 31583993
Neonatal seizure 11.36 10.75 11 109907 473 31586953
Discouragement 11.36 10.75 9 109909 295 31587131
Hypersensitivity 11.35 10.75 131 109787 55612 31531814
Pyromania 11.35 10.75 5 109913 52 31587374
Electrocardiogram QT interval abnormal 11.34 10.75 6 109912 96 31587330
Delusional disorder, unspecified type 11.30 10.75 13 109905 683 31586743
Butterfly rash 11.29 10.75 6 109912 97 31587329
Loss of employment 11.28 10.75 11 109907 477 31586949
Epstein-Barr virus infection 11.25 10.75 5 109913 6948 31580478
Morbid thoughts 11.24 10.75 8 109910 222 31587204
Fear 11.24 10.75 66 109852 9908 31577518
Gaze palsy 11.19 10.75 19 109899 1441 31585985
Poverty of speech 11.18 10.75 8 109910 224 31587202
Neutrophil count increased 11.17 10.75 93 109825 15638 31571788
Drug ineffective 11.10 10.75 1202 108716 394371 31193055
Pseudomonas infection 11.01 10.75 14 109904 11387 31576039
Neurotoxicity 10.99 10.75 25 109893 16201 31571225
Pseudocholinesterase deficiency 10.97 10.75 4 109914 24 31587402
Juvenile myoclonic epilepsy 10.95 10.75 5 109913 57 31587369
Inappropriate schedule of product administration 10.92 10.75 118 109800 50705 31536721
Yawning 10.91 10.75 11 109907 497 31586929
Ejection fraction decreased 10.91 10.75 28 109890 17406 31570020
General symptom 10.83 10.75 14 109904 831 31586595
Drug hypersensitivity 10.82 10.75 329 109589 72270 31515156
Hypercalcaemia 10.82 10.75 20 109898 13980 31573446
Skin necrosis 10.81 10.75 3 109915 5595 31581831
Congenital skin dimples 10.80 10.75 7 109911 166 31587260
Adrenal insufficiency 10.77 10.75 17 109901 12642 31574784

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Serotonin syndrome 1454.03 9.71 1236 268006 40878 70618324
Intentional self-injury 1328.51 9.71 1041 268201 30609 70628593
Depression 1218.58 9.71 2471 266771 196503 70462699
Suicidal ideation 1194.52 9.71 1396 267846 68200 70591002
Suicide attempt 1021.61 9.71 1380 267862 78130 70581072
Intentional overdose 1014.30 9.71 1538 267704 96897 70562305
Drug abuse 916.62 9.71 1842 267400 145414 70513788
Anxiety 859.93 9.71 2293 266949 218037 70441165
Drug interaction 817.87 9.71 3233 266009 378208 70280994
Completed suicide 612.27 9.71 2075 267167 225060 70434142
Agitation 517.22 9.71 1114 268128 92261 70566941
Rheumatoid arthritis 506.65 9.71 237 269005 291568 70367634
Tremor 453.17 9.71 1460 267782 154164 70505038
Sopor 365.72 9.71 519 268723 30748 70628454
Toxicity to various agents 364.31 9.71 2590 266652 379582 70279620
Synovitis 340.82 9.71 44 269198 129184 70530018
Akathisia 335.24 9.71 316 268926 11977 70647225
Aggression 322.64 9.71 624 268618 47822 70611380
Withdrawal syndrome 316.12 9.71 430 268812 24474 70634728
Hand deformity 287.10 9.71 9 269233 86473 70572729
Somnolence 286.13 9.71 1591 267651 214015 70445187
Overdose 284.18 9.71 1337 267905 168408 70490794
Paranoia 275.24 9.71 334 268908 16954 70642248
Pyrexia 257.89 9.71 1307 267935 605645 70053557
Confusional state 241.40 9.71 1876 267366 282522 70376680
Joint swelling 236.70 9.71 372 268870 252839 70406363
Hallucination, auditory 234.95 9.71 318 268924 18010 70641192
Drug intolerance 234.18 9.71 308 268934 225379 70433823
Hyponatraemia 232.40 9.71 1211 268031 158876 70500326
Mania 230.91 9.71 305 268937 16869 70642333
Infusion related reaction 229.02 9.71 247 268995 197287 70461915
Abnormal behaviour 228.56 9.71 445 268797 34264 70624938
Bruxism 227.77 9.71 154 269088 3575 70655627
Contraindicated product administered 227.77 9.71 113 269129 134499 70524703
Irritability 223.00 9.71 466 268776 37759 70621443
Dyskinesia 221.51 9.71 485 268757 40589 70618613
Psychotic disorder 220.40 9.71 460 268782 37241 70621961
Restlessness 217.68 9.71 489 268753 41639 70617563
Febrile neutropenia 210.77 9.71 280 268962 204038 70455164
Hallucination 206.12 9.71 698 268544 75562 70583640
Panic attack 205.75 9.71 330 268912 21789 70637413
Obsessive-compulsive disorder 202.56 9.71 166 269076 5204 70653998
Systemic lupus erythematosus 199.06 9.71 69 269173 101833 70557369
Treatment failure 194.43 9.71 157 269085 143985 70515217
Extrapyramidal disorder 192.22 9.71 309 268933 20441 70638761
Drug withdrawal syndrome 191.03 9.71 399 268843 32316 70626886
Pericarditis 188.19 9.71 45 269197 84660 70574542
Off label use 187.47 9.71 1861 267381 741199 69918003
Arthropathy 183.69 9.71 179 269063 149878 70509324
Glossodynia 176.97 9.71 54 269188 86433 70572769
Insomnia 174.39 9.71 1418 267824 216388 70442814
Arthralgia 172.92 9.71 1160 268082 502230 70156972
Anger 170.07 9.71 255 268987 15877 70643325
Stomatitis 163.51 9.71 148 269094 128363 70530839
Dystonia 160.52 9.71 277 268965 19429 70639773
Mydriasis 159.93 9.71 248 268994 15905 70643297
Homicidal ideation 156.24 9.71 117 269125 3206 70655996
Nasopharyngitis 153.03 9.71 390 268852 221816 70437386
Disturbance in attention 151.51 9.71 431 268811 42463 70616739
Parkinsonism 151.33 9.71 235 269007 15090 70644112
Electrocardiogram QT prolonged 150.87 9.71 673 268569 82844 70576358
Depressed mood 150.61 9.71 436 268806 43384 70615818
Delusion 150.39 9.71 265 268977 18900 70640302
Rash 149.30 9.71 1231 268011 509331 70149871
Tic 148.43 9.71 105 269137 2628 70656574
Mood swings 146.28 9.71 255 268987 18031 70641171
Hallucination, visual 142.11 9.71 332 268910 29005 70630197
Malignant neoplasm progression 141.28 9.71 152 269090 121587 70537615
Renal impairment 139.66 9.71 206 269036 143731 70515471
Hepatic enzyme increased 138.80 9.71 239 269003 156751 70502451
Feeling abnormal 137.72 9.71 969 268273 141350 70517852
Acute kidney injury 137.52 9.71 1147 268095 473477 70185725
Wound 133.79 9.71 107 269135 98625 70560577
Muscle rigidity 133.76 9.71 248 268994 18402 70640800
Disorientation 133.27 9.71 503 268739 57420 70601782
Hyperhidrosis 132.08 9.71 904 268338 130682 70528520
Therapeutic product effect decreased 131.75 9.71 212 269030 142806 70516396
Alopecia 131.60 9.71 355 268887 198135 70461067
Nightmare 131.43 9.71 272 268970 21884 70637318
Drug ineffective 128.77 9.71 2658 266584 937094 69722108
Major depression 127.38 9.71 160 269082 8414 70650788
Thrombocytopenia 126.72 9.71 473 268769 238637 70420565
Bradykinesia 126.08 9.71 149 269093 7353 70651849
Psychomotor hyperactivity 124.47 9.71 216 269026 15217 70643985
Loss of libido 124.32 9.71 91 269151 2406 70656796
Bradyphrenia 123.58 9.71 170 269072 9776 70649426
Neuroleptic malignant syndrome 123.45 9.71 292 268950 25715 70633487
Helicobacter infection 122.77 9.71 30 269212 55626 70603576
Self-injurious ideation 121.34 9.71 101 269141 3237 70655965
Anorgasmia 121.22 9.71 66 269176 1019 70658183
Apathy 120.94 9.71 185 269057 11723 70647479
Peripheral swelling 120.82 9.71 475 268767 236088 70423114
Seizure 120.13 9.71 1116 268126 176846 70482356
Duodenal ulcer perforation 119.92 9.71 24 269218 51088 70608114
Hypomania 119.69 9.71 131 269111 5941 70653261
Thinking abnormal 119.28 9.71 185 269057 11866 70647336
Neutropenia 119.19 9.71 536 268706 256620 70402582
General physical health deterioration 118.60 9.71 477 268765 235554 70423648
Pancytopenia 117.85 9.71 248 268994 150859 70508343
Loss of consciousness 117.71 9.71 1001 268241 154715 70504487
Sleep disorder due to general medical condition, insomnia type 117.58 9.71 4 269238 35728 70623474
Priapism 116.57 9.71 108 269134 4002 70655200
Treatment noncompliance 116.02 9.71 415 268827 46159 70613043
Folliculitis 115.87 9.71 13 269229 42557 70616645
Intrusive thoughts 113.96 9.71 47 269195 370 70658832
Homicide 111.20 9.71 64 269178 1106 70658096
Dizziness 111.09 9.71 2421 266821 461720 70197482
Social avoidant behaviour 110.65 9.71 111 269131 4545 70654657
Hyperprolactinaemia 108.18 9.71 107 269135 4306 70654896
Poisoning deliberate 107.79 9.71 215 269027 16845 70642357
Blood prolactin increased 107.16 9.71 99 269143 3655 70655547
Anaemia 105.31 9.71 1001 268241 402422 70256780
Sinusitis 104.48 9.71 313 268929 168882 70490320
C-reactive protein abnormal 104.46 9.71 12 269230 38567 70620635
Suicidal behaviour 103.96 9.71 89 269153 2967 70656235
Tachyphrenia 103.75 9.71 74 269168 1877 70657325
Myoclonus 103.17 9.71 275 268967 26080 70633122
Swelling 103.13 9.71 368 268874 188171 70471031
Sexual dysfunction 101.37 9.71 126 269116 6555 70652647
Infection 99.67 9.71 436 268806 210349 70448853
Oromandibular dystonia 99.34 9.71 55 269187 879 70658323
Pneumonia 99.01 9.71 1630 267612 594602 70064600
Inappropriate antidiuretic hormone secretion 98.43 9.71 250 268992 23026 70636176
Catatonia 98.04 9.71 137 269105 7996 70651206
C-reactive protein increased 97.89 9.71 168 269074 110349 70548853
Cardiac failure 97.18 9.71 254 268988 143287 70515915
Cytomegalovirus infection 96.83 9.71 17 269225 39741 70619461
Erectile dysfunction 95.58 9.71 179 269063 13383 70645819
Blister 95.43 9.71 146 269096 100380 70558822
Crying 95.23 9.71 233 269009 20966 70638236
Libido decreased 95.07 9.71 105 269137 4811 70654391
Muscle injury 94.76 9.71 16 269226 38478 70620724
Colitis microscopic 94.43 9.71 142 269100 8863 70650339
Emotional distress 94.02 9.71 333 268909 36855 70622347
Hypersensitivity 93.76 9.71 501 268741 229311 70429891
Psychomotor retardation 92.12 9.71 110 269132 5488 70653714
Amnesia 90.96 9.71 416 268826 51739 70607463
Impaired healing 89.50 9.71 90 269152 74284 70584918
Septic shock 89.41 9.71 182 269060 112076 70547126
Lower respiratory tract infection 88.66 9.71 182 269060 111731 70547471
Galactorrhoea 88.60 9.71 85 269157 3293 70655909
Muscle twitching 88.08 9.71 217 269025 19610 70639592
Neuropathy peripheral 87.85 9.71 222 269020 126674 70532528
Sepsis 87.55 9.71 556 268686 243989 70415213
Rheumatoid factor positive 87.47 9.71 37 269205 48363 70610839
Fall 86.25 9.71 2251 266991 441845 70217357
Delirium 86.08 9.71 531 268711 74083 70585119
Disease progression 84.87 9.71 307 268935 156365 70502837
Sedation 84.68 9.71 377 268865 46354 70612848
Hyperreflexia 83.29 9.71 121 269121 7321 70651881
Psoriatic arthropathy 83.07 9.71 74 269168 64697 70594505
Mental disorder 82.99 9.71 266 268976 27974 70631228
Trismus 80.45 9.71 98 269144 4993 70654209
Product use issue 80.38 9.71 380 268862 179557 70479645
Affective disorder 79.94 9.71 119 269123 7360 70651842
Product substitution issue 79.49 9.71 200 269042 18313 70640889
Maculopathy 78.37 9.71 71 269171 2555 70656647
Emotional disorder 78.01 9.71 162 269080 13064 70646138
Anhedonia 76.80 9.71 168 269074 14045 70645157
Discomfort 76.49 9.71 180 269062 105256 70553946
Hallucinations, mixed 76.44 9.71 107 269135 6255 70652947
Mucosal inflammation 76.19 9.71 87 269155 67763 70591439
Restless legs syndrome 75.92 9.71 196 269046 18232 70640970
Amenorrhoea 75.13 9.71 111 269131 6819 70652383
Speech disorder 74.93 9.71 385 268857 50195 70609007
Generalised tonic-clonic seizure 74.66 9.71 335 268907 41326 70617876
Depressive symptom 74.30 9.71 95 269147 5086 70654116
Euphoric mood 71.34 9.71 108 269134 6781 70652421
Obsessive thoughts 70.78 9.71 46 269196 997 70658205
Dysarthria 69.71 9.71 440 268802 61873 70597329
Intentional product misuse 68.97 9.71 528 268714 79067 70580135
Plasma cell myeloma 68.81 9.71 107 269135 73094 70586108
Psychomotor skills impaired 68.56 9.71 83 269159 4201 70655001
Abnormal dreams 67.44 9.71 134 269108 10469 70648733
Tardive dyskinesia 67.43 9.71 129 269113 9800 70649402
Platelet count decreased 66.99 9.71 399 268843 177823 70481379
Negative thoughts 66.76 9.71 49 269193 1301 70657901
Gestational diabetes 66.33 9.71 97 269145 5904 70653298
Yawning 65.90 9.71 48 269194 1259 70657943
Pleural effusion 65.74 9.71 270 268972 132594 70526608
Foaming at mouth 65.42 9.71 54 269188 1710 70657492
Activation syndrome 64.85 9.71 28 269214 250 70658952
Drug dependence 63.83 9.71 296 268946 37025 70622177
Schizophrenia 63.65 9.71 173 269069 16595 70642607
Depression suicidal 63.47 9.71 66 269176 2821 70656381
Inflammation 63.09 9.71 127 269115 78538 70580664
Respiratory arrest 62.94 9.71 385 268857 53548 70605654
Drug hypersensitivity 62.94 9.71 1370 267872 261089 70398113
Impulsive behaviour 62.42 9.71 64 269178 2690 70656512
Psychotic symptom 61.41 9.71 60 269182 2378 70656824
Abdominal discomfort 60.99 9.71 521 268721 214137 70445065
Mental impairment 60.55 9.71 173 269069 17082 70642120
Bone marrow failure 60.47 9.71 58 269184 48952 70610250
Flat affect 59.37 9.71 53 269189 1870 70657332
Prostate cancer 59.30 9.71 22 269220 31141 70628061
Salivary hypersecretion 59.05 9.71 143 269099 12782 70646420
Intentional product use issue 58.29 9.71 246 268996 119896 70539306
Gastrointestinal disorder 58.13 9.71 205 269037 105222 70553980
Hepatic function abnormal 57.82 9.71 106 269136 67890 70591312
Musculoskeletal pain 57.25 9.71 165 269077 90162 70569040
Torticollis 56.84 9.71 55 269187 2154 70657048
Memory impairment 56.56 9.71 569 268673 92072 70567130
Myelosuppression 56.17 9.71 22 269220 30123 70629079
Pneumocystis jirovecii pneumonia 55.98 9.71 22 269220 30060 70629142
Ascites 55.94 9.71 107 269135 67440 70591762
Abulia 55.64 9.71 38 269204 897 70658305
Bipolar I disorder 55.58 9.71 51 269191 1866 70657336
Derealisation 54.85 9.71 46 269196 1490 70657712
Reversible cerebral vasoconstriction syndrome 54.80 9.71 59 269183 2626 70656576
Rheumatic fever 54.72 9.71 3 269239 17657 70641545
Mood altered 53.80 9.71 161 269081 16314 70642888
Arthritis 53.70 9.71 191 269051 97789 70561413
Pain 53.66 9.71 1901 267341 626915 70032287
Infarction 53.45 9.71 73 269169 4169 70655033
Haemophagocytic lymphohistiocytosis 53.35 9.71 6 269236 19606 70639596
Antipsychotic drug level increased 53.12 9.71 83 269159 5357 70653845
Poisoning 52.47 9.71 197 269045 22425 70636777
Alcoholism 52.28 9.71 74 269168 4371 70654831
Irritable bowel syndrome 52.05 9.71 70 269172 50780 70608422
Tension 51.84 9.71 70 269172 3954 70655248
Persistent genital arousal disorder 51.75 9.71 25 269217 296 70658906
Genital hypoaesthesia 51.73 9.71 21 269221 158 70659044
Depersonalisation/derealisation disorder 51.65 9.71 47 269195 1701 70657501
Lung disorder 50.89 9.71 118 269124 69366 70589836
Vertigo 50.66 9.71 409 268833 62234 70596968
Disturbance in sexual arousal 50.41 9.71 21 269221 170 70659032
Hypersomnia 49.99 9.71 183 269059 20581 70638621
Neutrophil count decreased 49.82 9.71 157 269085 83399 70575803
Ill-defined disorder 49.58 9.71 82 269160 54659 70604543
Blood creatine phosphokinase increased 49.00 9.71 399 268843 60864 70598338
Bronchopulmonary aspergillosis 48.97 9.71 10 269232 20992 70638210
Dissociation 48.56 9.71 62 269180 3314 70655888
White blood cell count decreased 48.29 9.71 413 268829 169728 70489474
Bipolar disorder 48.20 9.71 96 269146 7512 70651690
Alcohol poisoning 47.44 9.71 70 269172 4295 70654907
Hip arthroplasty 46.70 9.71 24 269218 28016 70631186
Blepharospasm 46.69 9.71 65 269177 3780 70655422
Knee arthroplasty 46.67 9.71 37 269205 34264 70624938
Flashback 46.18 9.71 22 269220 252 70658950
Burning mouth syndrome 46.04 9.71 27 269215 484 70658718
Clonus 45.76 9.71 84 269158 6184 70653018
Bone erosion 45.74 9.71 3 269239 15170 70644032
Blood creatinine increased 45.73 9.71 336 268906 142665 70516537
Balance disorder 45.05 9.71 532 268710 89596 70569606
Interstitial lung disease 44.46 9.71 225 269017 104460 70554742
Dysphoria 44.44 9.71 69 269173 4429 70654773
Tearfulness 44.11 9.71 73 269169 4947 70654255
Pain in extremity 44.00 9.71 930 268312 327152 70332050
Dyspnoea 43.31 9.71 2437 266805 767623 69891579
Product complaint 43.28 9.71 123 269119 12108 70647094
Fear 43.20 9.71 175 269067 20636 70638566
Confabulation 42.78 9.71 25 269217 445 70658757
Eye movement disorder 42.56 9.71 90 269152 7350 70651852
Tumour lysis syndrome 42.50 9.71 14 269228 21346 70637856
Coma 42.38 9.71 534 268708 91310 70567892
Muscle tightness 42.32 9.71 119 269123 11643 70647559
Victim of chemical submission 42.25 9.71 24 269218 404 70658798
Cardiac arrest 42.08 9.71 846 268396 158988 70500214
Overweight 41.44 9.71 59 269183 3504 70655698
Formication 41.29 9.71 68 269174 4589 70654613
Cholecystitis chronic 40.99 9.71 102 269140 9274 70649928
Persistent depressive disorder 40.99 9.71 33 269209 1008 70658194
Emotional poverty 40.81 9.71 29 269213 731 70658471
Thrombotic microangiopathy 40.59 9.71 9 269233 17839 70641363
Drug reaction with eosinophilia and systemic symptoms 40.51 9.71 101 269141 57912 70601290
Haematotoxicity 40.36 9.71 3 269239 13671 70645531
Hyponatraemic seizure 40.36 9.71 25 269217 497 70658705
Violence-related symptom 40.17 9.71 28 269214 684 70658518
Herpes zoster 39.82 9.71 177 269065 85058 70574144
Sensation of foreign body 39.76 9.71 68 269174 4734 70654468
Transplant rejection 39.67 9.71 10 269232 18161 70641041
Dysphemia 39.38 9.71 55 269187 3208 70655994
Uterine perforation 39.34 9.71 76 269166 5815 70653387
Cytokine release syndrome 39.33 9.71 26 269216 26441 70632761
Poverty of thought content 39.18 9.71 13 269229 50 70659152
Cogwheel rigidity 38.80 9.71 52 269190 2916 70656286
Hyperkalaemia 38.79 9.71 241 269001 106350 70552852
Heavy menstrual bleeding 38.77 9.71 121 269121 12544 70646658
Tachycardia 38.73 9.71 830 268412 157716 70501486
Cycloplegia 38.62 9.71 9 269233 3 70659199
Drug screen positive 38.59 9.71 75 269167 5765 70653437
Leukopenia 38.23 9.71 242 269000 106318 70552884
Somnambulism 37.78 9.71 70 269172 5190 70654012
Drowning 37.49 9.71 28 269214 764 70658438
Renal failure 37.43 9.71 499 268743 188571 70470631
Abnormal weight gain 37.43 9.71 45 269197 2261 70656941
Pruritus 37.37 9.71 1012 268230 344548 70314654
Myelodysplastic syndrome 37.03 9.71 35 269207 29750 70629452
Disseminated intravascular coagulation 36.72 9.71 44 269198 33554 70625648
Osteoporosis 36.66 9.71 82 269160 48825 70610377
Syncope 36.55 9.71 855 268387 164854 70494348
Lethargy 36.21 9.71 441 268801 74809 70584393
Death 35.83 9.71 1577 267665 508484 70150718
Psychiatric decompensation 35.53 9.71 50 269192 2937 70656265
Attention deficit hyperactivity disorder 35.53 9.71 50 269192 2937 70656265
Self esteem decreased 35.52 9.71 29 269213 904 70658298
Semen discolouration 35.51 9.71 9 269233 8 70659194
Acute myeloid leukaemia 35.46 9.71 39 269203 30901 70628301
Blood pressure fluctuation 35.09 9.71 111 269131 58901 70600301
Urinary incontinence 35.02 9.71 255 268987 37587 70621615
Ejaculation failure 34.93 9.71 20 269222 342 70658860
Drug resistance 34.78 9.71 57 269185 38133 70621069
Adrenal insufficiency 34.50 9.71 27 269215 25168 70634034
Injection site pain 34.50 9.71 283 268959 117336 70541866
Palpitations 34.25 9.71 601 268641 110152 70549050
Atrial fibrillation 34.18 9.71 493 268749 183855 70475347
Disorganised speech 34.02 9.71 38 269204 1763 70657439
Diffuse large B-cell lymphoma 33.94 9.71 5 269237 13297 70645905
Nephropathy toxic 33.70 9.71 14 269228 18500 70640702
Premature ejaculation 33.66 9.71 12 269230 60 70659142
Ideas of reference 33.62 9.71 15 269227 146 70659056
Tubulointerstitial nephritis 33.38 9.71 46 269196 33030 70626172
Platelet aggregation abnormal 33.34 9.71 10 269232 25 70659177
Psychiatric symptom 33.06 9.71 76 269166 6568 70652634
Cough 32.85 9.71 962 268280 324415 70334787
Erythema 32.83 9.71 546 268696 199017 70460185
Somatic symptom disorder of pregnancy 32.82 9.71 13 269229 91 70659111
Palmar-plantar erythrodysaesthesia syndrome 32.65 9.71 40 269202 30207 70628995
Rabbit syndrome 32.63 9.71 19 269223 336 70658866
Food interaction 32.50 9.71 35 269207 1558 70657644
Pregnancy with implant contraceptive 32.21 9.71 35 269207 1574 70657628
Orgasm abnormal 32.18 9.71 15 269227 163 70659039
Basal cell carcinoma 31.91 9.71 49 269193 33649 70625553
Graft versus host disease 31.41 9.71 9 269233 15014 70644188
Multiple organ dysfunction syndrome 31.41 9.71 262 268980 108253 70550949
Sleep-related eating disorder 31.21 9.71 24 269218 685 70658517
Swollen tongue 31.11 9.71 244 268998 36802 70622400
Persecutory delusion 31.06 9.71 59 269183 4458 70654744
Upper gastrointestinal haemorrhage 31.01 9.71 246 268996 37231 70621971
Paraesthesia 30.89 9.71 747 268495 144790 70514412
Pneumonitis 30.87 9.71 105 269137 54492 70604710
Grandiosity 30.84 9.71 22 269220 558 70658644
Retroplacental haematoma 30.82 9.71 13 269229 109 70659093
Cytomegalovirus viraemia 30.74 9.71 4 269238 11681 70647521
Mutism 30.66 9.71 39 269203 2077 70657125
Device expulsion 30.66 9.71 166 269076 22080 70637122
Drug eruption 30.62 9.71 65 269177 39431 70619771
Negativism 30.58 9.71 25 269217 781 70658421
Sleep disorder 30.44 9.71 402 268840 69470 70589732
Lymphadenopathy 30.28 9.71 90 269152 48701 70610501
Cerebral vasoconstriction 30.12 9.71 31 269211 1309 70657893
Anaphylactic shock 30.05 9.71 48 269194 32442 70626760
Stiff person syndrome 29.91 9.71 18 269224 339 70658863
Posture abnormal 29.87 9.71 51 269191 3545 70655657
Dementia with Lewy bodies 29.70 9.71 24 269218 737 70658465
Action tremor 29.64 9.71 19 269223 402 70658800
Proteinuria 29.49 9.71 41 269201 29333 70629869
Cataract 29.48 9.71 110 269132 55535 70603667
Headache 29.22 9.71 2570 266672 577835 70081367
Device dislocation 29.05 9.71 165 269077 22342 70636860
Pressure of speech 28.97 9.71 27 269215 1008 70658194
Nervousness 28.96 9.71 210 269032 30910 70628292
Urinary hesitation 28.83 9.71 51 269191 3648 70655554
Pancreatic fibrosis 28.82 9.71 12 269230 97 70659105
Aspergillus infection 28.72 9.71 16 269226 17852 70641350
Rash maculo-papular 28.72 9.71 97 269145 50448 70608754
Ankylosing spondylitis 28.31 9.71 5 269237 11641 70647561
Mental status changes 28.30 9.71 365 268877 62736 70596466
Creatinine renal clearance decreased 28.23 9.71 15 269227 17185 70642017
Central vision loss 28.23 9.71 8 269234 15 70659187
Urine sodium decreased 28.13 9.71 16 269226 270 70658932
Acute psychosis 27.98 9.71 52 269190 3864 70655338
Physical assault 27.84 9.71 32 269210 1532 70657670
Delusion of replacement 27.83 9.71 13 269229 142 70659060
Chronic kidney disease 27.80 9.71 128 269114 60929 70598273
Drug dose titration not performed 27.66 9.71 23 269219 736 70658466
Complication of device insertion 27.65 9.71 62 269180 5270 70653932
Skin ulcer 27.63 9.71 92 269150 48053 70611149
Tongue spasm 27.53 9.71 11 269231 79 70659123
Middle insomnia 27.46 9.71 116 269126 13937 70645265
Post-traumatic stress disorder 27.19 9.71 55 269187 4352 70654850
Male sexual dysfunction 27.17 9.71 14 269228 192 70659010
Cytopenia 27.15 9.71 16 269226 17307 70641895
Cognitive disorder 27.09 9.71 352 268890 60604 70598598
Mobility decreased 27.03 9.71 255 268987 102744 70556458
Tinnitus 27.00 9.71 232 269010 35944 70623258
Obsessive-compulsive symptom 26.92 9.71 14 269228 196 70659006
Aplastic anaemia 26.82 9.71 15 269227 16701 70642501
Dissociative disorder 26.74 9.71 19 269223 479 70658723
Hypertonia 26.65 9.71 69 269173 6429 70652773
Rhabdomyolysis 26.58 9.71 511 268731 95249 70563953
Libido disorder 26.54 9.71 15 269227 250 70658952
Respiratory tract infection 26.46 9.71 78 269164 42320 70616882
Cardio-respiratory arrest 26.19 9.71 532 268710 100145 70559057
Phobia 26.18 9.71 17 269225 368 70658834
Antisocial behaviour 26.06 9.71 20 269222 569 70658633
Hyperphagia 25.88 9.71 38 269204 2321 70656881
Acute graft versus host disease 25.82 9.71 3 269239 9559 70649643
Pleurothotonus 25.80 9.71 38 269204 2328 70656874
Haemoglobin decreased 25.62 9.71 588 268654 204571 70454631
Nystagmus 25.58 9.71 86 269156 9269 70649933
Borderline personality disorder 25.49 9.71 23 269219 823 70658379
Antidepressant drug level increased 25.47 9.71 17 269225 386 70658816
Injection site erythema 25.44 9.71 167 269075 72757 70586445
Schizoaffective disorder bipolar type 25.38 9.71 13 269229 176 70659026
Embedded device 25.37 9.71 42 269200 2847 70656355
Hallucination, olfactory 25.36 9.71 18 269224 453 70658749
Negative symptoms in schizophrenia 25.30 9.71 12 269230 136 70659066
Pseudomonas infection 25.20 9.71 21 269221 18973 70640229
Head discomfort 25.06 9.71 107 269135 12916 70646286
Chorea 25.04 9.71 35 269207 2043 70657159
Decreased interest 24.98 9.71 46 269196 3395 70655807
Intermenstrual bleeding 24.97 9.71 59 269183 5191 70654011
Heart rate decreased 24.81 9.71 136 269106 61879 70597323
COVID-19 24.78 9.71 269 268973 105488 70553714
Respiratory failure 24.78 9.71 471 268771 168264 70490938
Muscle contractions involuntary 24.58 9.71 45 269197 3306 70655896
Heat stroke 24.55 9.71 30 269212 1533 70657669
Generalised anxiety disorder 24.50 9.71 34 269208 1971 70657231
Suppressed lactation 24.49 9.71 15 269227 292 70658910
Osteonecrosis of jaw 24.47 9.71 77 269165 40925 70618277
Dystonic tremor 24.38 9.71 13 269229 192 70659010
Panic disorder 24.30 9.71 41 269201 2823 70656379
Urticaria 24.29 9.71 454 268788 162595 70496607
Pathogen resistance 24.23 9.71 10 269232 13269 70645933
Hyperuricaemia 24.01 9.71 6 269236 10960 70648242
Factor XIII deficiency 24.00 9.71 10 269232 81 70659121
Unresponsive to stimuli 23.97 9.71 302 268940 51629 70607573
Substance abuse 23.93 9.71 87 269155 9750 70649452
Injection site pruritus 23.84 9.71 73 269169 39137 70620065
Cellulitis 23.84 9.71 250 268992 98678 70560524
Personality change 23.78 9.71 81 269161 8789 70650413
Prader-Willi syndrome 23.78 9.71 7 269235 16 70659186
Dermatillomania 23.75 9.71 13 269229 203 70658999
Injection site bruising 23.71 9.71 70 269172 37962 70621240
Morbid thoughts 23.67 9.71 21 269221 735 70658467
Febrile bone marrow aplasia 23.61 9.71 8 269234 11983 70647219
Liver disorder 23.56 9.71 137 269105 61431 70597771
Hyponatraemic syndrome 23.50 9.71 21 269221 742 70658460
Miosis 23.49 9.71 111 269131 13990 70645212
Phospholipidosis 23.48 9.71 11 269231 121 70659081
Device placement issue 23.44 9.71 22 269220 829 70658373
Drug screen false positive 23.40 9.71 24 269218 1009 70658193
Blood pressure diastolic abnormal 23.35 9.71 15 269227 15489 70643713
Radiologically isolated syndrome 23.33 9.71 6 269236 6 70659196
Granulocytopenia 23.28 9.71 91 269151 10556 70648646
Metabolic syndrome 23.11 9.71 37 269205 2438 70656764
Therapeutic response unexpected 23.10 9.71 133 269109 18098 70641104
Suspected suicide 23.10 9.71 80 269162 8754 70650448
Postmortem blood drug level increased 23.03 9.71 21 269221 762 70658440
Idiopathic intracranial hypertension 23.01 9.71 40 269202 2821 70656381
Peritonitis 22.94 9.71 40 269202 26119 70633083
Neoplasm progression 22.93 9.71 91 269151 45137 70614065
Diplopia 22.87 9.71 184 269058 27963 70631239
Multiple sclerosis relapse 22.87 9.71 257 268985 42760 70616442
Tuberculosis 22.87 9.71 14 269228 14834 70644368
Vanishing bile duct syndrome 22.85 9.71 27 269215 1332 70657870
Blood calcium decreased 22.76 9.71 47 269195 28799 70630403
Therapy non-responder 22.58 9.71 185 269057 76730 70582472
Hallucination, gustatory 22.48 9.71 9 269233 65 70659137
Cystitis haemorrhagic 22.46 9.71 3 269239 8590 70650612
Vision blurred 22.46 9.71 495 268747 94489 70564713
Enuresis 22.45 9.71 40 269202 2877 70656325
Affect lability 22.41 9.71 87 269155 10059 70649143
Polyneuropathy 22.40 9.71 29 269213 21386 70637816
Aphasia 22.37 9.71 257 268985 42992 70616210
Photophobia 22.30 9.71 134 269108 18516 70640686
Muscle contracture 22.16 9.71 34 269208 2160 70657042
Hereditary angioedema 22.08 9.71 55 269187 5004 70654198
Judgement impaired 22.08 9.71 24 269218 1080 70658122
Amniotic fluid volume increased 22.00 9.71 11 269231 141 70659061
Second primary malignancy 21.99 9.71 11 269231 13040 70646162
Exposure during pregnancy 21.99 9.71 461 268781 87256 70571946
Environmental exposure 21.93 9.71 15 269227 355 70658847
Conversion disorder 21.90 9.71 30 269212 1718 70657484
Resting tremor 21.80 9.71 27 269215 1399 70657803
Postural orthostatic tachycardia syndrome 21.78 9.71 18 269224 571 70658631
Neutropenic sepsis 21.74 9.71 38 269204 24792 70634410
Gaze palsy 21.66 9.71 38 269204 2700 70656502
Incoherent 21.63 9.71 69 269173 7237 70651965
Macrophages increased 21.61 9.71 12 269230 193 70659009
Rapid eye movements sleep abnormal 21.55 9.71 13 269229 246 70658956
Delusional disorder, unspecified type 21.54 9.71 20 269222 743 70658459
Psychogenic seizure 21.47 9.71 31 269211 1865 70657337
Movement disorder 21.41 9.71 161 269081 23968 70635234
Perinatal depression 21.20 9.71 14 269228 312 70658890
Oedema peripheral 21.13 9.71 682 268560 227409 70431793
Mitochondrial encephalomyopathy 21.08 9.71 7 269235 27 70659175
Male orgasmic disorder 20.96 9.71 8 269234 50 70659152
Alanine aminotransferase increased 20.94 9.71 414 268828 147066 70512136
Acute respiratory distress syndrome 20.92 9.71 83 269159 41171 70618031
Apallic syndrome 20.89 9.71 21 269221 862 70658340
Foreign body in reproductive tract 20.85 9.71 16 269226 455 70658747
Inappropriate affect 20.68 9.71 26 269216 1368 70657834
Alanine aminotransferase abnormal 20.63 9.71 3 269239 8056 70651146
Enterocolitis 20.57 9.71 12 269230 13054 70646148
Collagen-vascular disease 20.50 9.71 9 269233 84 70659118
Distractibility 20.46 9.71 19 269223 706 70658496
Therapeutic product effect incomplete 20.36 9.71 326 268916 119556 70539646
Gallbladder cholesterolosis 20.31 9.71 17 269225 549 70658653
Parkinsonism hyperpyrexia syndrome 20.27 9.71 12 269230 219 70658983
Oral candidiasis 20.24 9.71 40 269202 24912 70634290
Cold sweat 20.18 9.71 122 269120 16894 70642308
Social anxiety disorder 20.15 9.71 16 269226 479 70658723
Electrocardiogram T wave abnormal 20.11 9.71 42 269200 3400 70655802
Immunosuppressant drug level increased 20.11 9.71 3 269239 7904 70651298
Loose associations 20.08 9.71 8 269234 57 70659145
Eosinophilic pneumonia acute 20.07 9.71 21 269221 904 70658298
Feeling jittery 20.06 9.71 92 269150 11451 70647751
Stress 20.00 9.71 366 268876 67600 70591602
Localised infection 19.97 9.71 62 269180 33096 70626106
Diverticulitis 19.89 9.71 86 269156 41648 70617554
Dyspnoea exertional 19.80 9.71 196 269046 78234 70580968
Injury 19.78 9.71 353 268889 64892 70594310
Hepatocellular carcinoma 19.77 9.71 7 269235 10201 70649001
Merycism 19.76 9.71 12 269230 230 70658972
Morose 19.63 9.71 7 269235 35 70659167
Feeling drunk 19.61 9.71 48 269194 4319 70654883
Urinary retention 19.58 9.71 294 268948 52226 70606976
Coordination abnormal 19.57 9.71 116 269126 15950 70643252
Parkinsonian gait 19.44 9.71 20 269222 844 70658358
Musculoskeletal stiffness 19.43 9.71 420 268822 147340 70511862
Hyperbilirubinaemia 19.34 9.71 35 269207 22533 70636669
Impaired reasoning 19.29 9.71 9 269233 98 70659104
Lid lag 19.29 9.71 8 269234 64 70659138
Product communication issue 19.28 9.71 19 269223 761 70658441
Parasomnia 19.22 9.71 16 269226 513 70658689
Rales 19.20 9.71 22 269220 17113 70642089
Transient psychosis 19.18 9.71 8 269234 65 70659137
Tongue biting 19.16 9.71 29 269213 1820 70657382
Fibromyalgia 19.14 9.71 105 269137 47769 70611433
Tenosynovitis 19.11 9.71 15 269227 13961 70645241
Head injury 19.08 9.71 206 269036 33935 70625267
Colitis 18.95 9.71 153 269089 63661 70595541
COVID-19 pneumonia 18.89 9.71 34 269208 21935 70637267
Oesophageal carcinoma 18.88 9.71 6 269236 9360 70649842
Oedema 18.84 9.71 278 268964 103303 70555899
Hypocalcaemia 18.71 9.71 97 269145 44762 70614440
Fungal infection 18.61 9.71 76 269166 37391 70621811
Biliary dyskinesia 18.60 9.71 33 269209 2366 70656836
Catastrophic reaction 18.52 9.71 6 269236 21 70659181
Neurotoxicity 18.52 9.71 55 269187 29771 70629431
Metastases to lymph nodes 18.48 9.71 6 269236 9232 70649970
Excessive masturbation 18.47 9.71 8 269234 72 70659130
Cardiogenic shock 18.44 9.71 73 269169 36234 70622968
Ejaculation delayed 18.39 9.71 10 269232 154 70659048
Bleeding time prolonged 18.37 9.71 23 269219 1205 70657997
Medication error 18.37 9.71 311 268931 56601 70602601
Haemolytic anaemia 18.35 9.71 22 269220 16772 70642430
Intracranial meningioma malignant 18.31 9.71 4 269238 0 70659202
Sexual activity increased 18.31 9.71 6 269236 22 70659180
Pseudodementia 18.31 9.71 6 269236 22 70659180
Hyperacusis 18.29 9.71 30 269212 2018 70657184
Disinhibition 18.29 9.71 32 269210 2269 70656933
BK virus infection 18.22 9.71 4 269238 7985 70651217
Dopamine dysregulation syndrome 18.17 9.71 15 269227 475 70658727
Oral discomfort 18.12 9.71 74 269168 8757 70650445
Drop attacks 18.11 9.71 21 269221 1015 70658187
Drug level increased 18.10 9.71 215 269027 36254 70622948
Oxygen saturation decreased 18.02 9.71 322 268920 116107 70543095
Depressed level of consciousness 18.01 9.71 447 268795 86984 70572218
Drug-device interaction 17.92 9.71 8 269234 78 70659124
Feelings of worthlessness 17.88 9.71 15 269227 486 70658716
Aplasia 17.88 9.71 3 269239 7248 70651954
Polymenorrhoea 17.87 9.71 20 269222 930 70658272
Cardiac failure congestive 17.82 9.71 385 268857 135072 70524130
Reduced facial expression 17.78 9.71 32 269210 2320 70656882
Grip strength decreased 17.72 9.71 20 269222 15665 70643537
Diaphragmatic rupture 17.70 9.71 11 269231 220 70658982
Hepatic failure 17.65 9.71 137 269105 57488 70601714
Caesarean section 17.64 9.71 89 269153 11518 70647684
Foetal death 17.64 9.71 58 269184 6181 70653021
Metastases to lung 17.58 9.71 22 269220 16462 70642740
Dysgraphia 17.47 9.71 41 269201 3591 70655611
Blood pressure systolic abnormal 17.47 9.71 14 269228 12895 70646307
Loss of personal independence in daily activities 17.46 9.71 434 268808 84476 70574726
Conjunctival abrasion 17.43 9.71 5 269237 10 70659192
Target skin lesion 17.43 9.71 9 269233 124 70659078
Bursitis 17.43 9.71 48 269194 26625 70632577
Kidney transplant rejection 17.39 9.71 8 269234 9953 70649249
Communication disorder 17.36 9.71 42 269200 3752 70655450
Long QT syndrome 17.34 9.71 52 269190 5275 70653927
Torsade de pointes 17.29 9.71 123 269119 17993 70641209
Accommodation disorder 17.27 9.71 15 269227 510 70658692
Body mass index increased 17.25 9.71 27 269215 1745 70657457
Osteoarthritis 17.21 9.71 189 269053 73958 70585244
Panic reaction 17.15 9.71 45 269197 4226 70654976
Influenza 17.11 9.71 316 268926 113384 70545818
Pulmonary haemorrhage 17.08 9.71 16 269226 13657 70645545
Epstein-Barr virus infection 17.01 9.71 15 269227 13183 70646019
Drug abuser 17.01 9.71 55 269187 5809 70653393
Illness anxiety disorder 16.98 9.71 11 269231 237 70658965
Cardiac failure acute 16.97 9.71 25 269217 17462 70641740
Agitated depression 16.94 9.71 12 269230 301 70658901
Pneumonia bacterial 16.93 9.71 23 269219 16618 70642584
Conjunctivitis 16.93 9.71 38 269204 22598 70636604
Hypercalcaemia 16.92 9.71 70 269172 34315 70624887
Unintended pregnancy 16.91 9.71 38 269204 3235 70655967
Ataxia 16.86 9.71 148 269094 23069 70636133
Ejection fraction decreased 16.83 9.71 60 269182 30702 70628500
Erythromelalgia 16.82 9.71 10 269232 184 70659018
Suicide threat 16.77 9.71 7 269235 57 70659145
Complication of device removal 16.63 9.71 39 269203 3415 70655787
Serum serotonin decreased 16.53 9.71 5 269237 13 70659189
Bladder cancer 16.39 9.71 25 269217 17217 70641985
Pre-eclampsia 16.33 9.71 58 269184 6427 70652775
Cerebral infarction 16.29 9.71 96 269146 42913 70616289
Blood bilirubin increased 16.27 9.71 147 269095 59754 70599448
Lipidosis 16.27 9.71 5 269237 14 70659188
Daydreaming 16.24 9.71 18 269224 828 70658374
Glomerular filtration rate decreased 16.22 9.71 34 269208 20722 70638480
Boredom 16.21 9.71 6 269236 34 70659168
Urine chloride decreased 16.18 9.71 8 269234 100 70659102
Morning sickness 16.14 9.71 14 269228 475 70658727
Rhinovirus infection 16.13 9.71 3 269239 6730 70652472
Screaming 16.11 9.71 40 269202 3632 70655570
Gout 16.10 9.71 40 269202 22966 70636236
Glucose tolerance impaired in pregnancy 16.08 9.71 4 269238 3 70659199
Personality disorder 16.06 9.71 52 269190 5496 70653706
Joint hyperextension 16.02 9.71 11 269231 262 70658940
Maternal exposure during breast feeding 16.00 9.71 30 269212 2244 70656958
Feeling guilty 15.98 9.71 18 269224 843 70658359
Haemoptysis 15.91 9.71 122 269120 51330 70607872
Liver injury 15.86 9.71 91 269151 40944 70618258
Pulmonary tuberculosis 15.86 9.71 5 269237 7840 70651362
Brain injury 15.85 9.71 81 269161 10536 70648666
Neoplasm malignant 15.82 9.71 56 269186 28718 70630484
Death of relative 15.79 9.71 10 269232 207 70658995
Anorectal discomfort 15.71 9.71 36 269206 3105 70656097
Bladder dilatation 15.68 9.71 27 269215 1890 70657312
Skin toxicity 15.64 9.71 4 269238 7194 70652008
Abortion missed 15.64 9.71 21 269221 1180 70658022
Metastases to bone 15.59 9.71 39 269203 22337 70636865
Soliloquy 15.57 9.71 15 269227 584 70658618
CYP3A4 polymorphism 15.52 9.71 7 269235 70 70659132
Marital problem 15.50 9.71 10 269232 214 70658988
Polyarthritis 15.40 9.71 11 269231 10745 70648457
Stereotypy 15.36 9.71 18 269224 880 70658322
Red blood cell sedimentation rate increased 15.31 9.71 85 269157 38557 70620645
Menopausal disorder 15.27 9.71 6 269236 41 70659161
Selective mutism 15.27 9.71 7 269235 73 70659129
Product odour abnormal 15.23 9.71 21 269221 1210 70657992
Periodic limb movement disorder 15.22 9.71 9 269233 164 70659038
Hypoalbuminaemia 15.22 9.71 31 269211 19091 70640111
Oesophageal pain 15.21 9.71 40 269202 3762 70655440
Menstruation irregular 15.14 9.71 45 269197 4543 70654659
Fear of weight gain 15.12 9.71 5 269237 19 70659183
Feeling of despair 15.08 9.71 32 269210 2619 70656583
Gastrointestinal motility disorder 15.07 9.71 51 269191 5515 70653687
Cardiotoxicity 14.98 9.71 12 269230 11058 70648144
Blood pressure systolic increased 14.92 9.71 142 269100 57117 70602085
Hypoaesthesia eye 14.90 9.71 8 269234 120 70659082
Ophthalmic vein thrombosis 14.87 9.71 10 269232 230 70658972
Dementia Alzheimer's type 14.86 9.71 19 269223 1017 70658185
Petit mal epilepsy 14.85 9.71 50 269192 5394 70653808
Sluggishness 14.83 9.71 53 269189 5890 70653312
Asphyxia 14.81 9.71 78 269164 10264 70648938
Gallbladder injury 14.78 9.71 20 269222 1132 70658070
Reflexes abnormal 14.77 9.71 17 269225 815 70658387
Alcohol interaction 14.75 9.71 45 269197 4608 70654594
Optic ischaemic neuropathy 14.75 9.71 32 269210 2660 70656542
Hypokinesia 14.74 9.71 115 269127 17317 70641885
Aspartate aminotransferase increased 14.72 9.71 368 268874 126610 70532592
Paraneoplastic rash 14.71 9.71 7 269235 80 70659122
Postpartum haemorrhage 14.68 9.71 23 269219 1488 70657714
Differential white blood cell count abnormal 14.67 9.71 26 269216 1862 70657340
Renal injury 14.67 9.71 24 269218 16070 70643132
Hypochloraemia 14.67 9.71 28 269214 2123 70657079
Obsessive rumination 14.67 9.71 4 269238 6 70659196
Bronchitis 14.63 9.71 336 268906 116907 70542295
Respiratory tract congestion 14.58 9.71 28 269214 17625 70641577
Weight increased 14.56 9.71 1088 268154 241243 70417959
Dependence 14.54 9.71 29 269213 2271 70656931
Acute myocardial infarction 14.54 9.71 192 269050 72695 70586507
Partner stress 14.51 9.71 11 269231 307 70658895
Rebound psychosis 14.44 9.71 9 269233 181 70659021
Subchorionic haemorrhage 14.39 9.71 8 269234 129 70659073
Coagulopathy 14.37 9.71 71 269171 33178 70626024
Vascular dementia 14.37 9.71 17 269225 840 70658362
Vanishing twin syndrome 14.26 9.71 7 269235 86 70659116
Pulmonary toxicity 14.25 9.71 12 269230 10786 70648416
Menopause 14.23 9.71 25 269217 1778 70657424
Vomiting 14.22 9.71 2508 266734 590603 70068599
Blood pressure increased 14.21 9.71 578 268664 187939 70471263
Basophil count abnormal 14.19 9.71 5 269237 24 70659178
Pyromania 14.19 9.71 5 269237 24 70659178
Peripheral sensory neuropathy 14.17 9.71 15 269227 12095 70647107
Water intoxication 14.14 9.71 16 269226 753 70658449
Hypersexuality 14.10 9.71 23 269219 1540 70657662
Joint range of motion decreased 14.08 9.71 51 269191 25975 70633227
Facet joint syndrome 14.07 9.71 3 269239 6110 70653092
Anal incontinence 14.06 9.71 109 269133 16381 70642821
Levator syndrome 14.02 9.71 5 269237 25 70659177
Oral herpes 14.02 9.71 46 269196 24140 70635062
Alcohol use 13.97 9.71 44 269198 4583 70654619
Incontinence 13.95 9.71 91 269151 12937 70646265
Fear of injection 13.95 9.71 4 269238 6668 70652534
Diarrhoea 13.92 9.71 2692 266550 780649 69878553
Cholangitis 13.86 9.71 14 269228 11535 70647667
Hepatic cancer 13.74 9.71 10 269232 9673 70649529
Overconfidence 13.73 9.71 3 269239 0 70659202
Olfactory nerve disorder 13.73 9.71 3 269239 0 70659202
Arterial ligation 13.73 9.71 3 269239 0 70659202
Anaplastic large cell lymphoma T- and null-cell types stage IV 13.73 9.71 3 269239 0 70659202
Postictal headache 13.73 9.71 3 269239 0 70659202
Autoimmune disorder 13.67 9.71 8 269234 8688 70650514
Hyporesponsive to stimuli 13.62 9.71 25 269217 1840 70657362
Somatic delusion 13.62 9.71 15 269227 685 70658517
Blood triglycerides increased 13.59 9.71 124 269118 19540 70639662
Female orgasmic disorder 13.56 9.71 5 269237 28 70659174
Sciatica 13.49 9.71 48 269194 24579 70634623
Renal tubular necrosis 13.48 9.71 44 269198 23127 70636075
Haemorrhagic hepatic cyst 13.48 9.71 6 269236 58 70659144
Hepatitis B 13.43 9.71 7 269235 8107 70651095
Breast enlargement 13.35 9.71 21 269221 1363 70657839
Pulmonary microemboli 13.34 9.71 4 269238 10 70659192
Compulsions 13.31 9.71 11 269231 349 70658853
Schizophreniform disorder 13.28 9.71 8 269234 151 70659051
Maternal drugs affecting foetus 13.24 9.71 23 269219 1621 70657581
Jaundice 13.17 9.71 124 269118 49984 70609218
Metastases to liver 13.16 9.71 52 269190 25826 70633376
Drooling 13.16 9.71 48 269194 5388 70653814
Pelvic pain 13.15 9.71 82 269160 11478 70647724
Gait deviation 13.14 9.71 6 269236 62 70659140
Alcohol abuse 13.14 9.71 46 269196 5061 70654141
Helplessness 13.12 9.71 11 269231 356 70658846
Lack of spontaneous speech 13.12 9.71 9 269233 214 70658988
Concomitant disease aggravated 13.10 9.71 16 269226 12098 70647104
Herpes simplex 13.05 9.71 14 269228 11218 70647984
Metabolic acidosis 13.02 9.71 201 269041 74145 70585057
Tongue haematoma 13.01 9.71 9 269233 217 70658985
Dermatitis acneiform 13.01 9.71 9 269233 8936 70650266
Presyncope 12.97 9.71 207 269035 37231 70621971
Cardiac failure chronic 12.84 9.71 12 269230 10257 70648945
Intestinal perforation 12.77 9.71 26 269216 16018 70643184
Abnormal loss of weight 12.77 9.71 61 269181 7723 70651479
Painful erection 12.74 9.71 8 269234 163 70659039
Multiple-drug resistance 12.70 9.71 6 269236 7349 70651853
Herbal interaction 12.66 9.71 12 269230 458 70658744
Gastrointestinal perforation 12.65 9.71 3 269239 5678 70653524
Device related infection 12.64 9.71 71 269171 32114 70627088
Blood ethanol increased 12.63 9.71 14 269228 644 70658558
Temporomandibular joint syndrome 12.62 9.71 36 269206 3551 70655651
Genital anaesthesia 12.57 9.71 4 269238 13 70659189
Ear infection 12.54 9.71 60 269182 28276 70630926
Increased appetite 12.53 9.71 76 269166 10537 70648665
Factor XIII Inhibition 12.50 9.71 5 269237 36 70659166
Hyperthermia 12.49 9.71 107 269135 16564 70642638
Gait disturbance 12.48 9.71 839 268403 184267 70474935
Blood lactate dehydrogenase increased 12.48 9.71 80 269162 35047 70624155
Alveolar bone resorption 12.42 9.71 6 269236 71 70659131
Product taste abnormal 12.41 9.71 26 269216 2110 70657092
Pharyngeal swelling 12.40 9.71 53 269189 6400 70652802
Osteomyelitis 12.39 9.71 66 269176 30252 70628950
Bankruptcy 12.39 9.71 5 269237 37 70659165
Slow response to stimuli 12.37 9.71 23 269219 1710 70657492
Rheumatoid nodule 12.35 9.71 24 269218 15043 70644159
Libido increased 12.34 9.71 24 269218 1845 70657357
Drug dispensed to wrong patient 12.32 9.71 13 269229 565 70658637
Tunnel vision 12.32 9.71 19 269223 1212 70657990
Renal cancer 12.31 9.71 16 269226 11780 70647422
Ectopic pregnancy 12.31 9.71 22 269220 1586 70657616
Epistaxis 12.28 9.71 296 268946 102331 70556871
Energy increased 12.22 9.71 31 269211 2853 70656349
Implant site irritation 12.21 9.71 7 269235 120 70659082
Schizoaffective disorder 12.19 9.71 25 269217 1998 70657204
Malpositioned teeth 12.16 9.71 5 269237 39 70659163
Breast cancer stage I 12.14 9.71 4 269238 6098 70653104
Atrioventricular dissociation 12.13 9.71 10 269232 316 70658886
Trichotillomania 12.13 9.71 8 269234 178 70659024
Injection site swelling 12.12 9.71 105 269137 43052 70616150
Gastric hypomotility 12.09 9.71 8 269234 179 70659023
Oesophageal ulcer haemorrhage 12.08 9.71 13 269229 578 70658624
Hypotension 12.08 9.71 1347 267895 403034 70256168
Female sexual dysfunction 12.05 9.71 5 269237 40 70659162
Mallory-Weiss syndrome 12.05 9.71 29 269213 2582 70656620
Exposure via breast milk 12.02 9.71 16 269226 891 70658311
Oropharyngeal pain 12.02 9.71 276 268966 96034 70563168
Abnormal uterine bleeding 12.00 9.71 16 269226 893 70658309
Constipation 11.98 9.71 811 268431 251627 70407575
Compulsive sexual behaviour 11.94 9.71 9 269233 249 70658953
Vaginal haemorrhage 11.93 9.71 124 269118 20228 70638974
Blood urea increased 11.89 9.71 114 269128 45795 70613407
Food craving 11.89 9.71 21 269221 1500 70657702
Lactate pyruvate ratio increased 11.86 9.71 6 269236 79 70659123
Change of bowel habit 11.84 9.71 29 269213 2610 70656592
Serositis 11.82 9.71 15 269227 797 70658405
Atrial septal defect 11.81 9.71 23 269219 1770 70657432
Amniotic cavity infection 11.80 9.71 15 269227 798 70658404
Impaired self-care 11.79 9.71 27 269215 2327 70656875
Haematuria 11.77 9.71 170 269072 63403 70595799
Mood disorder due to a general medical condition 11.74 9.71 5 269237 43 70659159
Vasodilation procedure 11.74 9.71 5 269237 43 70659159
Anxiety disorder due to a general medical condition 11.74 9.71 4 269238 17 70659185
Gambling disorder 11.74 9.71 24 269218 1914 70657288
Large intestine perforation 11.73 9.71 20 269222 13175 70646027
Lymphomatoid papulosis 11.71 9.71 10 269232 332 70658870
Hypersensitivity pneumonitis 11.71 9.71 34 269208 3388 70655814
Peripheral venous disease 11.67 9.71 14 269228 10673 70648529
Disturbance in social behaviour 11.67 9.71 38 269204 4029 70655173
Nasal cavity packing 11.67 9.71 3 269239 3 70659199
Hippocampal atrophy 11.67 9.71 3 269239 3 70659199
Barbiturates positive 11.67 9.71 3 269239 3 70659199
Polymenorrhagia 11.64 9.71 5 269237 44 70659158
Maternal exposure during pregnancy 11.62 9.71 341 268901 115004 70544198
Suspiciousness 11.61 9.71 13 269229 605 70658597
Dementia 11.61 9.71 133 269109 22232 70636970
Premature baby 11.60 9.71 34 269208 3405 70655797
Purple glove syndrome 11.58 9.71 9 269233 261 70658941
Musculoskeletal disorder 11.57 9.71 38 269204 19933 70639269
Ejaculation disorder 11.56 9.71 12 269230 512 70658690
Product use in unapproved indication 11.51 9.71 657 268585 206821 70452381
Lymphoproliferative disorder 11.50 9.71 3 269239 5326 70653876
Hepatotoxicity 11.49 9.71 109 269133 43877 70615325
Drug tolerance increased 11.49 9.71 13 269229 612 70658590
Poor personal hygiene 11.48 9.71 12 269230 516 70658686
Pneumatosis intestinalis 11.47 9.71 4 269238 5883 70653319
Eczema 11.46 9.71 78 269164 33703 70625499
Aphthous ulcer 11.46 9.71 24 269218 14632 70644570
Self-medication 11.41 9.71 40 269202 4403 70654799
Logorrhoea 11.41 9.71 38 269204 4076 70655126
Cytomegalovirus chorioretinitis 11.40 9.71 3 269239 5295 70653907
Body temperature decreased 11.40 9.71 63 269179 28609 70630593
Hippocampal sclerosis 11.40 9.71 7 269235 137 70659065
Maternal condition affecting foetus 11.40 9.71 7 269235 137 70659065
Delusional perception 11.39 9.71 10 269232 345 70658857
Tongue discolouration 11.39 9.71 34 269208 3440 70655762
Sleep inertia 11.39 9.71 4 269238 19 70659183
Behaviour disorder 11.38 9.71 46 269196 5418 70653784
Hypokalaemia 11.37 9.71 608 268634 130580 70528622
Foetal exposure during pregnancy 11.35 9.71 47 269195 5598 70653604
Blood test abnormal 11.32 9.71 24 269218 14566 70644636
Skin infection 11.29 9.71 28 269214 16084 70643118
Transaminases increased 11.25 9.71 119 269123 46899 70612303
Shoplifting 11.21 9.71 3 269239 4 70659198
Breast discomfort 11.20 9.71 10 269232 353 70658849
Retching 11.16 9.71 101 269141 15878 70643324
Rash erythematous 11.15 9.71 134 269108 51584 70607618
Implant site extravasation 11.15 9.71 14 269228 736 70658466
Delusion of reference 11.13 9.71 7 269235 143 70659059
Drug-induced liver injury 11.13 9.71 148 269094 55965 70603237
Hypersensitivity vasculitis 11.12 9.71 6 269236 6816 70652386
Dyspraxia 11.12 9.71 9 269233 277 70658925
Mixed dementia 11.01 9.71 9 269233 281 70658921
Candida infection 11.01 9.71 81 269161 34392 70624810
Platelet aggregation decreased 11.00 9.71 5 269237 51 70659151
Respiratory dyskinesia 11.00 9.71 5 269237 51 70659151
Endophthalmitis 10.96 9.71 5 269237 6250 70652952
Tendonitis 10.90 9.71 45 269197 22077 70637125
Appetite disorder 10.89 9.71 54 269188 6941 70652261
Neutropenic colitis 10.81 9.71 3 269239 5111 70654091
Premature rupture of membranes 10.81 9.71 36 269206 3862 70655340
Joint injury 10.80 9.71 59 269183 26873 70632329
Transfusion 10.80 9.71 36 269206 18800 70640402
Coprolalia 10.75 9.71 5 269237 54 70659148
Exposure via ingestion 10.74 9.71 42 269200 4873 70654329
Parakeratosis 10.74 9.71 10 269232 373 70658829
Arrested labour 10.72 9.71 7 269235 153 70659049
Serum ferritin increased 10.71 9.71 11 269231 8994 70650208
Pneumothorax 10.71 9.71 56 269186 25790 70633412
Back pain 10.66 9.71 885 268357 270267 70388935
Metastases to central nervous system 10.63 9.71 26 269216 15008 70644194
Deprescribing error 10.62 9.71 4 269238 24 70659178
Autoscopy 10.59 9.71 5 269237 56 70659146
Illusion 10.59 9.71 21 269221 1638 70657564
Pulmonary arterial hypertension 10.59 9.71 77 269165 32778 70626424
Poverty of speech 10.57 9.71 12 269230 567 70658635
Premature labour 10.56 9.71 59 269183 7941 70651261
Gun shot wound 10.56 9.71 17 269225 1126 70658076
Hepatic lesion 10.54 9.71 5 269237 6112 70653090
Nervous system disorder 10.54 9.71 139 269103 24007 70635195
Renal tubular disorder 10.52 9.71 5 269237 6105 70653097
Haematemesis 10.51 9.71 251 268991 48546 70610656
Inadequate analgesia 10.49 9.71 37 269205 4085 70655117
Pulmonary mass 10.46 9.71 57 269185 25976 70633226
Epilepsy 10.43 9.71 206 269036 38578 70620624
Nausea 10.43 9.71 3496 265746 848592 69810610
Wound infection 10.42 9.71 33 269209 17509 70641693
Impulse-control disorder 10.41 9.71 21 269221 1658 70657544
Blood citric acid increased 10.37 9.71 5 269237 59 70659143
Faeces discoloured 10.36 9.71 151 269091 26658 70632544
Bacteraemia 10.28 9.71 67 269175 29242 70629960
Pelvic inflammatory disease 10.27 9.71 18 269224 1278 70657924
Anal abscess 10.18 9.71 10 269232 8348 70650854
Retroperitoneal fibrosis 10.17 9.71 12 269230 591 70658611
Unmasking of previously unidentified disease 10.17 9.71 22 269220 1825 70657377
Breast pain 10.15 9.71 55 269187 7316 70651886
Pancreatic enzymes decreased 10.15 9.71 3 269239 7 70659195
Antidepressant drug level decreased 10.15 9.71 3 269239 7 70659195
Amnestic disorder 10.14 9.71 12 269230 593 70658609
Sickle cell anaemia with crisis 10.13 9.71 5 269237 5973 70653229
Liver function test increased 10.12 9.71 81 269161 33766 70625436
Reflux laryngitis 10.11 9.71 6 269236 110 70659092
Seizure like phenomena 10.11 9.71 21 269221 1694 70657508
Sensitivity to weather change 10.06 9.71 8 269234 7397 70651805
Alcohol intolerance 10.06 9.71 10 269232 405 70658797
Initial insomnia 10.03 9.71 49 269193 6260 70652942
Facial discomfort 10.01 9.71 5 269237 64 70659138
Systemic candida 10 9.71 5 269237 5929 70653273
Staring 9.99 9.71 26 269216 2430 70656772
Snoring 9.99 9.71 41 269201 4863 70654339
Right ventricular failure 9.96 9.71 47 269195 22227 70636975
Gallbladder disorder 9.95 9.71 107 269135 17605 70641597
Leukaemoid reaction 9.93 9.71 9 269233 324 70658878
Stoma site infection 9.91 9.71 18 269224 1314 70657888
Coronary arterial stent insertion 9.86 9.71 5 269237 5882 70653320
Visceral congestion 9.85 9.71 14 269228 830 70658372
Labour complication 9.81 9.71 5 269237 67 70659135
Diabetes mellitus 9.78 9.71 203 269039 71621 70587581
Methaemoglobinaemia 9.77 9.71 3 269239 4783 70654419
Acanthosis nigricans 9.76 9.71 7 269235 179 70659023
Duplicate therapy error 9.76 9.71 8 269234 251 70658951
Squamous cell carcinoma 9.75 9.71 26 269216 14578 70644624
Poor venous access 9.74 9.71 27 269215 14944 70644258
Chronic fatigue syndrome 9.72 9.71 17 269225 1205 70657997

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Agitation neonatal 35.47 18.76 60 2171 588 86973
Premature baby 28.68 18.76 34 2197 3894 83667
Human herpesvirus 6 infection 21.16 18.76 15 2216 45 87516
Fever neonatal 18.97 18.76 9 2222 8 87553

Pharmacologic Action:

SourceCodeDescription
ATC N06AB06 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Selective serotonin reuptake inhibitors
FDA MoA N0000000109 Serotonin Uptake Inhibitors
CHEBI has role CHEBI:35469 antidepressants
CHEBI has role CHEBI:50949 SSRI
FDA EPC N0000175696 Serotonin Reuptake Inhibitor
FDA MoA N0000182137 Cytochrome P450 2D6 Inhibitors
MeSH PA D000928 Antidepressive Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018490 Serotonin Agents
MeSH PA D017367 Serotonin Uptake Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Premenstrual dysphoric disorder indication 596004
Social phobia indication 25501002 DOID:11257
Depressive disorder indication 35489007
Posttraumatic stress disorder indication 47505003 DOID:2055
Obsessive-compulsive disorder indication 191736004 DOID:10933
Panic disorder indication 371631005 DOID:594
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Seasonal affective disorder off-label use 247803002
Cholestatic pruritus off-label use 707150004
Suicidal thoughts contraindication 6471006
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Upper gastrointestinal hemorrhage contraindication 37372002
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Blood coagulation disorder contraindication 64779008 DOID:1247
Weight loss contraindication 89362005
Hyponatremia contraindication 89627008
Seizure disorder contraindication 128613002
Mania contraindication 231494001
Hypomania contraindication 231496004
Disease of liver contraindication 235856003 DOID:409
Serotonin syndrome contraindication 371089000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.61 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter INHIBITOR Kd 9.54 CHEMBL CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 7.24 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel Ki 5.17 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Kd 6.38 WOMBAT-PK
5-hydroxytryptamine receptor 2A GPCR Ki 6.11 DRUG MATRIX
5-hydroxytryptamine receptor 2B GPCR Ki 5.67 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 6.25 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR Ki 6.86 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 7.08 DRUG MATRIX
Muscarinic acetylcholine receptor M1 GPCR Ki 6.13 PDSP
Muscarinic acetylcholine receptor M2 GPCR Ki 5.68 PDSP
Muscarinic acetylcholine receptor M3 GPCR Ki 5.89 PDSP
Muscarinic acetylcholine receptor M4 GPCR Ki 5.85 PDSP
Muscarinic acetylcholine receptor M5 GPCR Ki 5.72 PDSP
Alpha-2C adrenergic receptor GPCR Ki 6.19 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Kd 7.60 WOMBAT-PK
Cytochrome P450 2C19 Enzyme IC50 6 DRUG MATRIX
Melanocortin receptor 5 GPCR Ki 5.37 DRUG MATRIX
Alpha-2A adrenergic receptor GPCR Ki 6.97 DRUG MATRIX
Alpha-1B adrenergic receptor GPCR Ki 6.48 DRUG MATRIX
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 5.89 DRUG MATRIX
Sodium-dependent serotonin transporter Transporter Ki 9.07 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 7.11 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 7.24 CHEMBL
Transporter Transporter Ki 6.80 CHEMBL
Transcriptional activator protein luxR Unclassified IC50 4.57 CHEMBL
Sigma intracellular receptor 2 Unclassified Ki 5.28 CHEMBL

External reference:

IDSource
4020551 VUID
N0000148257 NUI
D00825 KEGG_DRUG
79559-97-0 SECONDARY_CAS_RN
4020394 VANDF
4020551 VANDF
C0074393 UMLSCUI
CHEBI:9123 CHEBI
SRE PDB_CHEM_ID
CHEMBL809 ChEMBL_ID
DB01104 DRUGBANK_ID
CHEMBL1709 ChEMBL_ID
D020280 MESH_DESCRIPTOR_UI
68617 PUBCHEM_CID
4798 IUPHAR_LIGAND_ID
5277 INN_ID
QUC7NX6WMB UNII
155137 RXNORM
169461 MMSL
39959 MMSL
5457 MMSL
83167 MMSL
d00880 MMSL
003629 NDDF
004615 NDDF
321958004 SNOMEDCT_US
372594008 SNOMEDCT_US
96211006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Zoloft HUMAN PRESCRIPTION DRUG LABEL 1 0049-0050 SOLUTION, CONCENTRATE 20 mg ORAL NDA 32 sections
Zoloft HUMAN PRESCRIPTION DRUG LABEL 1 0049-4900 TABLET, FILM COATED 50 mg ORAL NDA 32 sections
Zoloft HUMAN PRESCRIPTION DRUG LABEL 1 0049-4910 TABLET, FILM COATED 100 mg ORAL NDA 32 sections
Zoloft HUMAN PRESCRIPTION DRUG LABEL 1 0049-4960 TABLET, FILM COATED 25 mg ORAL NDA 32 sections
Sertraline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9580 TABLET, FILM COATED 100 mg ORAL ANDA 31 sections
Sertraline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9581 TABLET, FILM COATED 50 mg ORAL ANDA 31 sections
Sertraline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9582 TABLET, FILM COATED 25 mg ORAL ANDA 31 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0143-9654 TABLET, FILM COATED 100 mg ORAL ANDA 31 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0143-9655 TABLET, FILM COATED 50 mg ORAL ANDA 31 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0143-9656 TABLET, FILM COATED 25 mg ORAL ANDA 31 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0615-7989 TABLET, FILM COATED 25 mg ORAL ANDA 24 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0615-7989 TABLET, FILM COATED 25 mg ORAL ANDA 24 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0615-7990 TABLET, FILM COATED 50 mg ORAL ANDA 24 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0615-7990 TABLET, FILM COATED 50 mg ORAL ANDA 24 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0615-7991 TABLET, FILM COATED 100 mg ORAL ANDA 24 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0615-7991 TABLET, FILM COATED 100 mg ORAL ANDA 24 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0904-6924 TABLET, FILM COATED 25 mg ORAL ANDA 30 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0904-6925 TABLET, FILM COATED 50 mg ORAL ANDA 30 sections
Sertraline HUMAN PRESCRIPTION DRUG LABEL 1 0904-6926 TABLET, FILM COATED 100 mg ORAL ANDA 30 sections
Sertraline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10135-694 SOLUTION 20 mg ORAL ANDA 28 sections
Sertraline Hydrochloride Human Prescription Drug Label 1 13107-011 TABLET 25 mg ORAL ANDA 26 sections
Sertraline Hydrochloride Human Prescription Drug Label 1 13107-012 TABLET 50 mg ORAL ANDA 26 sections
Sertraline Hydrochloride Human Prescription Drug Label 1 13107-013 TABLET 100 mg ORAL ANDA 26 sections
ZOLOFT HUMAN PRESCRIPTION DRUG LABEL 1 16590-250 TABLET, FILM COATED 50 mg ORAL NDA 31 sections
ZOLOFT HUMAN PRESCRIPTION DRUG LABEL 1 16590-251 TABLET, FILM COATED 100 mg ORAL NDA 31 sections
SERTRALINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-416 TABLET 100 mg ORAL ANDA 25 sections
SERTRALINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-457 TABLET 50 mg ORAL ANDA 25 sections
SERTRALINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-700 TABLET 25 mg ORAL ANDA 25 sections
Sertraline Hydrochloride Human Prescription Drug Label 1 16714-601 SOLUTION 20 mg ORAL ANDA 30 sections
Sertraline Hydrochloride Human Prescription Drug Label 1 16714-611 TABLET, FILM COATED 25 mg ORAL ANDA 31 sections