sertindole Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2435 106516-24-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sertindole hydrochloride
  • sertindole HCl
  • Lu-23-174
  • Lu 23-174
  • sertindole
  • serdolect
  • zerdol
an antipsychotic drug with selective inhibitory effect on mesolimbic dopaminergic neurons and balanced inhibitory effects on central dopamine D2 and serotonin 5HT2 receptors as well as on alpha1-adrenergic receptors
  • Molecular weight: 440.95
  • Formula: C24H26ClFN4O
  • CLOGP: 5.27
  • LIPINSKI: 1
  • HAC: 5
  • HDO: 1
  • TPSA: 40.51
  • ALOGS: -4.66
  • ROTB: 5

Drug dosage:

DoseUnitRoute
16 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Hosey CM, Chan R, Benet LZ
BA (Bioavailability) 74 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
May 23, 1996 UK Medicines and Healthcare Products Regulatory Agency (MHRA) H. Lundbeck A/S

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05AE03 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Indole derivatives
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D011619 Psychotropic Drugs
CHEBI has role CHEBI:65191 second generation antipsychotic
CHEBI has role CHEBI:48279 serotonergic antagonist
CHEBI has role CHEBI:37890 alpha-adrenergic antagonist
CHEBI has role CHEBI:37955 H1-receptor antagonist
MeSH PA D014149 Tranquilizing Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Schizophrenia indication 58214004 DOID:5419

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.74 acidic
pKa2 8.5 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
5-hydroxytryptamine receptor 2C GPCR INVERSE AGONIST Ki 9.70 CHEMBL SCIENTIFIC LITERATURE
D(2) dopamine receptor GPCR ANTAGONIST Ki 9.35 CHEMBL SCIENTIFIC LITERATURE
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 9.22 CHEMBL SCIENTIFIC LITERATURE
Alpha-2C adrenergic receptor GPCR Ki 6.35 PDSP
Alpha-2B adrenergic receptor GPCR Ki 6.35 PDSP
Alpha-2A adrenergic receptor GPCR Ki 6.19 PDSP
5-hydroxytryptamine receptor 1D GPCR ANTAGONIST Ki 7.20 IUPHAR
5-hydroxytryptamine receptor 1F GPCR ANTAGONIST Ki 6.40 IUPHAR
5-hydroxytryptamine receptor 1E GPCR ANTAGONIST Ki 6.40 IUPHAR
Beta-2 adrenergic receptor GPCR Ki 5.30 PDSP
Beta-1 adrenergic receptor GPCR Ki 5.30 PDSP
Multidrug resistance protein 1 Transporter IC50 5.19 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 7.48 CHEMBL
D(1A) dopamine receptor GPCR Ki 6.68 CHEMBL
D(4) dopamine receptor GPCR Ki 7.96 CHEMBL
5-hydroxytryptamine receptor 1B GPCR Ki 7.25 CHEMBL
Histamine H1 receptor GPCR Ki 9.29 CHEMBL
D(3) dopamine receptor GPCR Ki 8.59 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 8.57 CHEMBL
5-hydroxytryptamine receptor 6 GPCR Ki 8.30 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 8.74 PDSP
5-hydroxytryptamine receptor 7 GPCR Ki 7.55 PDSP
Muscarinic acetylcholine receptor M3 GPCR Ki 5.57 PDSP
Alpha-1B adrenergic receptor GPCR Ki 9.48 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR IC50 9.41 CHEMBL
D(1A) dopamine receptor GPCR Ki 7.92 CHEMBL
Alpha-1D adrenergic receptor GPCR Ki 9.18 CHEMBL
5-hydroxytryptamine receptor 2C GPCR Ki 9.29 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 9.70 CHEMBL
Adrenergic receptor alpha-1 GPCR Ki 8.85 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 9.43 CHEMBL
Alpha-1A adrenergic receptor GPCR IC50 8.47 CHEMBL
D(2) dopamine receptor GPCR Ki 9.35 CHEMBL

External reference:

IDSource
4025271 VUID
N0000179296 NUI
C0084528 UMLSCUI
D00561 KEGG_DRUG
321603004 SNOMEDCT_US
418732002 SNOMEDCT_US
4025271 VANDF
006145 NDDF
41996 RXNORM
CHEMBL12713 ChEMBL_ID
GVV4Z879SP UNII
6455 INN_ID
DB06144 DRUGBANK_ID
CHEBI:9122 CHEBI
60149 PUBCHEM_CID
98 IUPHAR_LIGAND_ID
C066304 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None