sertaconazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| systemic antifungal agents, miconazole derivatives | 2434 | 99592-32-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 0 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 10, 2003 | FDA | VALEANT LUXEMBOURG |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Urethral valves | 96.24 | 68.05 | 11 | 73 | 275 | 34956572 |
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D01AC14 | DERMATOLOGICALS ANTIFUNGALS FOR DERMATOLOGICAL USE ANTIFUNGALS FOR TOPICAL USE Imidazole and triazole derivatives |
| ATC | G01AF19 | GENITO URINARY SYSTEM AND SEX HORMONES GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS Imidazole derivatives |
| FDA CS | M0002083 | Azoles |
| FDA EPC | N0000175487 | Azole Antifungal |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000935 | Antifungal Agents |
| CHEBI has role | CHEBI:35475 | non-steroidal anti-inflammatory agent |
| CHEBI has role | CHEBI:36047 | antibacterial drugs |
| CHEBI has role | CHEBI:59683 | antipruritic drugs |
| CHEBI has role | CHEBI:77884 | sterol 14alpha-demethylase inhibitor |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Tinea pedis | indication | 6020002 | DOID:12403 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 6.49 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Indoleamine 2,3-dioxygenase 1 | Enzyme | IC50 | 5.08 | CHEMBL | |||||
| Lanosterol 14-alpha demethylase | Enzyme | INHIBITOR | WOMBAT-PK | CHEMBL | |||||
| Cholinesterase | Enzyme | IC50 | 5.13 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4021471 | VUID |
| N0000148855 | NUI |
| D06883 | KEGG_DRUG |
| 99592-39-9 | SECONDARY_CAS_RN |
| 4021471 | VANDF |
| C0074391 | UMLSCUI |
| CHEBI:82866 | CHEBI |
| CHEMBL1201196 | ChEMBL_ID |
| CHEMBL1200725 | ChEMBL_ID |
| DB01153 | DRUGBANK_ID |
| C061131 | MESH_SUPPLEMENTAL_RECORD_UI |
| 6008 | INN_ID |
| 72W71I16EG | UNII |
| 65863 | PUBCHEM_CID |
| 236601 | RXNORM |
| 17708 | MMSL |
| 006417 | NDDF |
| 006418 | NDDF |
| 409280001 | SNOMEDCT_US |
| 409281002 | SNOMEDCT_US |
| 426726001 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Ertaczo | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-5115 | CREAM | 20 mg | TOPICAL | NDA | 23 sections |
| ERTACZO | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-454 | CREAM | 20 mg | TOPICAL | ANDA | 21 sections |