sermorelin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| growth hormone release-stimulating peptides | 2433 | 86168-78-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
The biologically active fragment of human growth hormone-releasing factor, consisting of GHRH(1-29)-amide. This N-terminal sequence is identical in several mammalian species, such as human, pig, and cattle. It is used to diagnose or treat patients with GROWTH HORMONE deficiency.
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 0.34 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 39.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 0.19 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 28, 1990 | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | H01AC04 | SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES ANTERIOR PITUITARY LOBE HORMONES AND ANALOGUES Somatropin and somatropin agonists |
| ATC | V04CD03 | VARIOUS DIAGNOSTIC AGENTS OTHER DIAGNOSTIC AGENTS Tests for pituitary function |
| CHEBI has role | CHEBI:33295 | diagnostic aid |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Pituitary dwarfism | indication | 367460001 | DOID:0060870 |
| Diagnostic Test for Growth Hormone Secretion | indication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.49 | acidic |
| pKa2 | 4.09 | acidic |
| pKa3 | 9.4 | acidic |
| pKa4 | 10.0 | acidic |
| pKa5 | 11.94 | acidic |
| pKa6 | 12.09 | acidic |
| pKa7 | 12.55 | acidic |
| pKa8 | 12.58 | acidic |
| pKa9 | 12.75 | acidic |
| pKa10 | 12.81 | acidic |
| pKa11 | 12.95 | acidic |
| pKa12 | 13.12 | acidic |
| pKa13 | 13.19 | acidic |
| pKa14 | 13.31 | acidic |
| pKa15 | 13.47 | acidic |
| pKa16 | 13.52 | acidic |
| pKa17 | 13.59 | acidic |
| pKa18 | 13.68 | acidic |
| pKa19 | 13.82 | acidic |
| pKa20 | 13.82 | acidic |
| pKa21 | 13.99 | acidic |
| pKa22 | 11.48 | Basic |
| pKa23 | 11.1 | Basic |
| pKa24 | 10.75 | Basic |
| pKa25 | 10.46 | Basic |
| pKa26 | 10.07 | Basic |
| pKa27 | 7.76 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Growth hormone-releasing hormone receptor | GPCR | AGONIST | UNKNOWN | IUPHAR |
External reference:
| ID | Source |
|---|---|
| 4019553 | VUID |
| N0000179347 | NUI |
| D02117 | KEGG_DRUG |
| 114466-38-5 | SECONDARY_CAS_RN |
| 4019553 | VANDF |
| 4019931 | VANDF |
| C0142046 | UMLSCUI |
| CHEBI:9118 | CHEBI |
| CHEMBL1201490 | ChEMBL_ID |
| CHEMBL2108862 | ChEMBL_ID |
| D017337 | MESH_DESCRIPTOR_UI |
| DB00010 | DRUGBANK_ID |
| 6998 | IUPHAR_LIGAND_ID |
| 6036 | INN_ID |
| 89243S03TE | UNII |
| 16132413 | PUBCHEM_CID |
| 56188 | RXNORM |
| 5456 | MMSL |
| d04259 | MMSL |
| 004104 | NDDF |
| 004160 | NDDF |
| 109203000 | SNOMEDCT_US |
| 395870004 | SNOMEDCT_US |
| 412303008 | SNOMEDCT_US |
Pharmaceutical products:
None