aripiprazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
psychotropics, phenylpiperazine derivatives 242 129722-12-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • aripiprazole hydrate
  • aripiprazole
  • abilify
  • arpizol
  • pripiprazole
  • OPC-14597
A piperazine and quinolone derivative that is used primarily as an antipsychotic agent. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, where it also functions as a post-synaptic antagonist, and an antagonist of SEROTONIN RECEPTOR, 5-HT2A. It is used for the treatment of SCHIZOPHRENIA and BIPOLAR DISORDER, and as an adjunct therapy for the treatment of depression.
  • Molecular weight: 448.39
  • Formula: C23H27Cl2N3O2
  • CLOGP: 5.11
  • LIPINSKI: 1
  • HAC: 5
  • HDO: 1
  • TPSA: 44.81
  • ALOGS: -4.76
  • ROTB: 7
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
15 mg O
13.30 mg P
15 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.00 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.56 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 87 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 4.90 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.83 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 75 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 4.445 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.069 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 11.324 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 16.749 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 0.360 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 1.700 % High 1
herg hERG pIC50 5.895 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 5.383 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 36.983 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 0.280 % High 1
kinase-safety-class ACVR2B,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK3,MAP3K7,MAPK10,MAPK7,MET,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIM2,PRKDC,SIK2,TEK,TGFBR1 30
kinase-selectivity-class AXL,EIF2AK3,GRK2,PDK4 4
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.809 High 1
mh-clint Mouse hepatocyte intrinsic clearance 38.994 High 1
mppb Mouse plasma protein binding (% unbound) 0.400 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 3.027 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1
pppb Pig plasma protein binding (% unbound) 0.740 % High 1
rh-clint Rat hepatocyte intrinsic clearance 57.677 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 3.110 % High 1
rppb Rat plasma protein binding (% unbound) 0.320 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 1.656 uM High 1

Approvals:

DateAgencyCompanyOrphan
Jan. 23, 2006 PMDA Otsuka Pharmaceutical Co., Ltd
June 4, 2004 EMA
Nov. 15, 2002 FDA OTSUKA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Akathisia 2257.93 11.90 760 118254 10399 90499034
Tardive dyskinesia 2052.88 11.90 704 118310 10226 90499207
Dystonia 1701.85 11.90 688 118326 16131 90493302
Extrapyramidal disorder 1622.45 11.90 659 118355 15644 90493789
Suicide attempt 1417.25 11.90 1001 118013 74398 90435035
Sedation 1262.49 11.90 787 118227 47384 90462049
Dyskinesia 1261.06 11.90 713 118301 35821 90473612
Suicidal ideation 1193.58 11.90 895 118119 72960 90436473
Hallucination, auditory 1107.50 11.90 500 118514 15475 90493958
Sexual dysfunction 1050.37 11.90 347 118667 4457 90504976
Psychotic disorder 1030.73 11.90 592 118422 30638 90478795
Blood prolactin abnormal 1025.93 11.90 311 118703 2955 90506478
Parkinsonism 1022.15 11.90 455 118559 13610 90495823
Neuroleptic malignant syndrome 953.83 11.90 443 118571 14653 90494780
Drug interaction 951.21 11.90 1468 117546 274985 90234448
Treatment noncompliance 894.19 11.90 653 118361 51074 90458359
Delusion 824.54 11.90 390 118624 13450 90495983
Anosognosia 808.64 11.90 264 118750 3258 90506175
Product use in unapproved indication 754.97 11.90 1479 117535 334757 90174676
Mania 750.55 11.90 368 118646 13756 90495677
Hyperprolactinaemia 747.66 11.90 278 118736 5155 90504278
Disturbance in social behaviour 744.47 11.90 259 118755 3929 90505504
Tremor 734.56 11.90 954 118060 152219 90357214
Schizoaffective disorder 717.96 11.90 266 118748 4881 90504552
Weight increased 679.55 11.90 1613 117401 416314 90093119
Oculogyric crisis 676.81 11.90 212 118802 2267 90507166
Metabolic disorder 661.81 11.90 278 118736 7192 90502241
Intentional self-injury 608.22 11.90 414 118600 28920 90480513
Intentional overdose 606.03 11.90 680 118334 93154 90416279
Personality change 594.05 11.90 256 118758 7065 90502368
Electrocardiogram QT prolonged 591.90 11.90 595 118419 71861 90437572
Somnolence 527.04 11.90 967 118047 208117 90301316
Abnormal behaviour 513.92 11.90 338 118676 22290 90487143
Psychotic symptom 481.32 11.90 160 118854 2096 90507337
Restlessness 456.06 11.90 377 118637 35343 90474090
Agitation 439.53 11.90 490 118524 66608 90442825
Drug abuse 437.33 11.90 540 118474 81807 90427626
Salivary hypersecretion 424.42 11.90 217 118797 8875 90500558
Drug level increased 398.90 11.90 314 118700 27448 90481985
Joint swelling 394.87 11.90 89 118925 503211 90006222
Systemic lupus erythematosus 389.61 11.90 21 118993 361875 90147558
Aggression 381.82 11.90 301 118713 26367 90483066
Infusion related reaction 376.32 11.90 51 118963 416729 90092704
Stubbornness 370.84 11.90 90 118924 322 90509111
Glossodynia 365.01 11.90 13 119001 321766 90187667
Anxiety 356.10 11.90 1052 117962 308720 90200713
Gambling disorder 349.85 11.90 109 118905 1143 90508290
Galactorrhoea 348.55 11.90 154 118860 4518 90504915
Arthropathy 342.30 11.90 40 118974 366202 90143231
Psychiatric decompensation 333.19 11.90 117 118897 1826 90507607
Irritability 328.72 11.90 313 118701 35349 90474084
Contraindicated product administered 319.94 11.90 27 118987 320112 90189321
Swelling 313.13 11.90 82 118932 418976 90090457
Schizophrenia 310.30 11.90 211 118803 14703 90494730
Abdominal discomfort 306.23 11.90 122 118892 477206 90032227
Thinking abnormal 302.86 11.90 190 118824 11542 90497891
Blood glucose increased 292.49 11.90 481 118533 94765 90414668
Muscle rigidity 289.56 11.90 199 118815 14110 90495323
Pain 284.19 11.90 550 118464 995791 89513642
Arthralgia 283.25 11.90 365 118649 778157 89731276
Helicobacter infection 281.47 11.90 3 119011 226847 90282586
Blood prolactin increased 274.92 11.90 121 118893 3516 90505917
Completed suicide 262.52 11.90 585 118429 144473 90364960
Gestational diabetes 262.22 11.90 167 118847 10415 90499018
Pericarditis 261.27 11.90 26 118988 270125 90239308
Mental impairment 259.53 11.90 198 118816 16522 90492911
Metabolic syndrome 257.82 11.90 96 118918 1786 90507647
Alopecia 255.77 11.90 168 118846 494903 90014530
Drug intolerance 255.05 11.90 135 118879 447456 90061977
Folliculitis 247.83 11.90 4 119010 204349 90305084
Orthostatic hypertension 242.13 11.90 69 118945 516 90508917
Rash 239.53 11.90 425 118589 795675 89713758
Hypersensitivity 239.33 11.90 151 118863 454526 90054907
Rheumatoid arthritis 233.56 11.90 92 118922 362522 90146911
Overdose 230.16 11.90 585 118429 157124 90352309
Stomatitis 228.84 11.90 42 118972 274656 90234777
Underdose 224.30 11.90 314 118700 53703 90455730
Foetal exposure during pregnancy 223.52 11.90 279 118735 42696 90466737
Mental disorder 221.89 11.90 242 118772 32076 90477357
Persecutory delusion 220.96 11.90 100 118914 3108 90506325
Diarrhoea 218.33 11.90 579 118435 938611 89570822
Paranoia 216.21 11.90 160 118854 12748 90496685
Hepatic enzyme increased 215.67 11.90 102 118912 360634 90148799
Psychomotor hyperactivity 215.02 11.90 159 118855 12654 90496779
Muscle injury 211.96 11.90 4 119010 176650 90332783
Impaired healing 210.40 11.90 29 118985 234170 90275263
Dyspnoea 208.60 11.90 538 118476 880417 89629016
Irritable bowel syndrome 208.54 11.90 17 118997 207431 90302002
Sinusitis 208.20 11.90 95 118919 342993 90166440
Abortion spontaneous 206.49 11.90 302 118712 53754 90455679
Blister 203.97 11.90 43 118971 254955 90254478
Psychiatric symptom 203.38 11.90 123 118891 6995 90502438
Hallucinations, mixed 203.21 11.90 115 118899 5774 90503659
Impulse-control disorder 198.98 11.90 67 118947 915 90508518
Psoriatic arthropathy 198.81 11.90 31 118983 228304 90281129
Catatonia 197.55 11.90 114 118900 5942 90503491
Nasopharyngitis 197.16 11.90 148 118866 406956 90102477
Diabetes mellitus 192.90 11.90 323 118691 64552 90444881
Lower respiratory tract infection 191.02 11.90 47 118967 250612 90258821
Depression 190.67 11.90 841 118173 299760 90209673
Hallucination 190.29 11.90 324 118690 65635 90443798
Mobility decreased 187.25 11.90 49 118965 250685 90258748
Depressed mood 186.66 11.90 277 118737 49945 90459488
Wrong technique in product usage process 186.28 11.90 336 118678 71235 90438198
Mood altered 186.25 11.90 165 118849 16979 90492454
Serotonin syndrome 185.99 11.90 239 118775 37648 90471785
Blood creatine phosphokinase increased 185.17 11.90 226 118788 33797 90475636
Pneumonia 182.50 11.90 351 118663 637708 89871725
Discomfort 180.92 11.90 67 118947 274268 90235165
Sopor 175.24 11.90 188 118826 24456 90484977
Cogwheel rigidity 168.86 11.90 73 118941 2029 90507404
Drug hypersensitivity 168.60 11.90 217 118797 463392 90046041
Social avoidant behaviour 166.69 11.90 84 118930 3329 90506104
Compulsive shopping 165.89 11.90 55 118959 714 90508719
Wound 165.77 11.90 96 118918 302884 90206549
Apathy 165.34 11.90 128 118886 10912 90498521
Hallucination, visual 163.91 11.90 176 118838 22916 90486517
Bipolar disorder 163.26 11.90 117 118897 8868 90500565
Osteoarthritis 162.81 11.90 30 118984 195700 90313733
Therapeutic product effect decreased 160.51 11.90 82 118932 277489 90231944
Maternal exposure during pregnancy 157.45 11.90 907 118107 359156 90150277
Suppressed lactation 156.58 11.90 47 118967 430 90509003
Toxicity to various agents 156.50 11.90 770 118244 287076 90222357
Infarction 155.55 11.90 77 118937 2936 90506497
Joint range of motion decreased 155.39 11.90 5 119009 135638 90373795
Pruritus 154.66 11.90 298 118716 541227 89968206
Sleep disorder due to general medical condition, insomnia type 154.02 11.90 3 119011 128691 90380742
Wheezing 153.87 11.90 60 118954 238020 90271413
Peripheral swelling 153.68 11.90 190 118824 412916 90096517
Insurance issue 151.08 11.90 121 118893 10837 90498596
Hostility 150.70 11.90 69 118945 2204 90507229
Sinus tachycardia 149.68 11.90 186 118828 28327 90481106
General physical health deterioration 148.91 11.90 148 118866 354967 90154466
Caesarean section 148.72 11.90 151 118863 18426 90491007
Hypersexuality 148.05 11.90 48 118966 578 90508855
Increased appetite 147.67 11.90 123 118891 11642 90497791
Gastrointestinal disorder 145.20 11.90 78 118936 256609 90252824
C-reactive protein abnormal 144.90 11.90 5 119009 127424 90382009
Drug monitoring procedure incorrectly performed 144.41 11.90 41 118973 302 90509131
Ill-defined disorder 144.13 11.90 33 118981 184858 90324575
Hypomania 143.91 11.90 108 118906 8789 90500644
Disturbance in attention 140.63 11.90 235 118779 46874 90462559
Fibromyalgia 140.02 11.90 48 118966 206221 90303212
Posture abnormal 139.12 11.90 69 118945 2642 90506791
Antipsychotic drug level increased 139.11 11.90 77 118937 3702 90505731
Drooling 136.22 11.90 81 118933 4465 90504968
Infection 135.21 11.90 166 118848 361928 90147505
Musculoskeletal pain 132.62 11.90 31 118983 171220 90338213
Amenorrhoea 127.69 11.90 113 118901 11609 90497824
Vertigo 126.70 11.90 282 118732 69529 90439904
Substance abuse 123.31 11.90 81 118933 5325 90504108
Affective disorder 122.50 11.90 93 118921 7700 90501733
Muscle twitching 122.45 11.90 155 118859 24047 90485386
Seizure 122.03 11.90 459 118555 152170 90357263
Impulsive behaviour 119.38 11.90 54 118960 1676 90507757
Obsessive-compulsive disorder 118.91 11.90 74 118940 4430 90505003
Logorrhoea 118.39 11.90 62 118952 2665 90506768
Bursitis 116.56 11.90 17 118997 131637 90377796
Refusal of treatment by patient 116.55 11.90 80 118934 5658 90503775
Hyperphagia 116.47 11.90 62 118952 2756 90506677
Pulmonary fibrosis 116.30 11.90 6 119008 107497 90401936
Liver injury 115.22 11.90 40 118974 170527 90338906
Lip dry 114.64 11.90 4 119010 100951 90408482
Urticaria 112.95 11.90 147 118867 312587 90196846
Urinary retention 112.28 11.90 188 118826 37556 90471877
Inflammation 112.13 11.90 47 118967 178545 90330888
Urinary incontinence 111.60 11.90 187 118827 37379 90472054
Fatigue 111.25 11.90 976 118038 1153047 89356386
Depressive symptom 110.47 11.90 75 118939 5210 90504223
Abortion induced 103.22 11.90 101 118913 11787 90497646
Psychomotor retardation 102.58 11.90 69 118945 4720 90504713
Cognitive disorder 99.64 11.90 256 118758 69151 90440282
Rhabdomyolysis 98.62 11.90 212 118802 51044 90458389
Thermal burn 98.22 11.90 77 118937 6685 90502748
Pain in extremity 98.14 11.90 286 118728 450243 90059190
Inappropriate schedule of product administration 97.58 11.90 423 118591 149510 90359923
Grip strength decreased 97.58 11.90 6 119008 92570 90416863
Arthritis 97.32 11.90 49 118965 167266 90342167
Poisoning deliberate 97.06 11.90 114 118900 16372 90493061
Treatment failure 96.82 11.90 156 118858 303772 90205661
Peripheral venous disease 96.44 11.90 3 119011 83918 90425515
Wound infection 95.92 11.90 13 119001 106389 90403044
Depressed level of consciousness 95.88 11.90 260 118754 72524 90436909
Gambling 95.10 11.90 28 118986 238 90509195
Lung disorder 93.19 11.90 40 118974 149843 90359590
Anaemia 93.08 11.90 203 118811 352599 90156834
Acute myopia 92.90 11.90 25 118989 147 90509286
Anger 92.88 11.90 102 118912 13618 90495815
Rabbit syndrome 92.49 11.90 29 118985 311 90509122
Abdominal pain upper 92.31 11.90 186 118828 332488 90176945
Coma 92.24 11.90 256 118758 72376 90437057
Libido increased 91.31 11.90 45 118969 1699 90507734
Disease progression 90.89 11.90 46 118968 156569 90352864
Euphoric mood 90.48 11.90 67 118947 5342 90504091
Economic problem 89.39 11.90 55 118959 3226 90506207
Night sweats 89.05 11.90 29 118985 128737 90380696
Disinhibition 88.78 11.90 38 118976 1030 90508403
Eosinophil count decreased 87.91 11.90 54 118960 3158 90506275
Gaze palsy 87.88 11.90 43 118971 1598 90507835
Febrile neutropenia 86.79 11.90 50 118964 158299 90351134
Hypothermia 85.61 11.90 104 118910 15471 90493962
Sinus rhythm 85.43 11.90 40 118974 1346 90508087
Abdominal pain 84.86 11.90 253 118761 395468 90113965
Premature delivery 84.76 11.90 169 118845 38593 90470840
Abortion 84.27 11.90 50 118964 2745 90506688
Bradyphrenia 84.15 11.90 74 118940 7538 90501895
Malignant neoplasm progression 83.41 11.90 19 118995 106851 90402582
Flat affect 83.24 11.90 42 118972 1669 90507764
Antipsychotic drug level above therapeutic 82.40 11.90 39 118975 1345 90508088
Tic 81.68 11.90 43 118971 1868 90507565
Blood cholesterol increased 81.18 11.90 92 118922 207920 90301513
Pyrexia 80.29 11.90 523 118491 659962 89849471
Personality disorder 79.91 11.90 90 118924 12354 90497079
Acute psychosis 79.81 11.90 50 118964 3028 90506405
Injury 79.53 11.90 85 118929 197264 90312169
Pregnancy 79.09 11.90 219 118795 61828 90447605
Contusion 78.08 11.90 131 118883 251085 90258348
Hypertonia 77.70 11.90 60 118954 5095 90504338
Symptom recurrence 77.60 11.90 54 118960 3905 90505528
Myoclonus 77.43 11.90 110 118904 19058 90490375
Poor personal hygiene 75.91 11.90 26 118988 375 90509058
Pregnancy on contraceptive 75.60 11.90 36 118978 1259 90508174
Myocarditis 75.58 11.90 92 118922 13714 90495719
Bipolar I disorder 75.48 11.90 42 118972 2040 90507393
Altered state of consciousness 74.44 11.90 142 118872 31390 90478043
Mutism 73.34 11.90 39 118975 1730 90507703
Refusal of examination 73.22 11.90 22 118992 202 90509231
Intentional product use issue 73.20 11.90 107 118907 216785 90292648
Dysarthria 73.14 11.90 196 118818 54286 90455147
Personality change due to a general medical condition 71.70 11.90 23 118991 267 90509166
Dyspepsia 71.65 11.90 93 118921 198067 90311366
Oedema 71.40 11.90 95 118919 200200 90309233
Cough 71.34 11.90 247 118767 368715 90140718
Mood swings 70.97 11.90 110 118904 20592 90488841
Therapy cessation 70.64 11.90 151 118863 36210 90473223
Miosis 70.34 11.90 74 118940 9410 90500023
Autoimmune disorder 70.08 11.90 9 119005 76735 90432698
Eye movement disorder 70.02 11.90 61 118953 6137 90503296
Prescribed underdose 69.65 11.90 237 118777 74782 90434651
Knee arthroplasty 68.60 11.90 13 119001 83169 90426264
Off label use 68.56 11.90 1912 117102 1100340 89409093
Self-injurious ideation 68.25 11.90 46 118968 3157 90506276
Self-destructive behaviour 67.09 11.90 25 118989 466 90508967
Apraxia 66.98 11.90 40 118974 2222 90507211
Restless legs syndrome 66.93 11.90 112 118902 22358 90487075
Paraesthesia 66.84 11.90 143 118871 250183 90259250
Cardio-respiratory arrest 66.28 11.90 208 118806 62932 90446501
Loss of consciousness 66.27 11.90 361 118653 139877 90369556
Gait inability 66.08 11.90 57 118957 146399 90363034
Behaviour disorder 65.64 11.90 52 118962 4583 90504850
Decreased appetite 65.03 11.90 264 118750 376276 90133157
Torticollis 64.94 11.90 41 118973 2517 90506916
Sciatica 64.72 11.90 26 118988 101356 90408077
Insomnia 64.67 11.90 696 118318 332778 90176655
Blunted affect 64.54 11.90 21 118993 256 90509177
Trimethylaminuria 63.38 11.90 19 118995 173 90509260
Soliloquy 63.02 11.90 22 118992 337 90509096
Hypoaesthesia 63.01 11.90 207 118807 314003 90195430
Hip arthroplasty 62.66 11.90 12 119002 76196 90433237
Stupor 62.02 11.90 54 118960 5428 90504005
Binge eating 62.02 11.90 25 118989 580 90508853
Nail disorder 61.73 11.90 4 119010 59063 90450370
Disease recurrence 61.56 11.90 146 118868 37507 90471926
Neutrophil count increased 59.56 11.90 98 118916 19292 90490141
Hypercholesterolaemia 59.48 11.90 29 118985 100863 90408570
Victim of crime 59.48 11.90 27 118987 845 90508588
Post-traumatic stress disorder 59.26 11.90 58 118956 6770 90502663
Hypokinesia 58.91 11.90 87 118927 15610 90493823
Suicidal behaviour 58.59 11.90 40 118974 2804 90506629
Dysphagia 58.52 11.90 297 118717 111981 90397452
Lactation disorder 57.98 11.90 22 118992 432 90509001
Autism spectrum disorder 57.85 11.90 30 118984 1263 90508170
Nightmare 57.78 11.90 103 118911 21622 90487811
Compulsive sexual behaviour 57.70 11.90 14 119000 50 90509383
Bruxism 57.65 11.90 47 118967 4316 90505117
Enuresis 56.46 11.90 42 118972 3372 90506061
Dissociation 56.35 11.90 56 118958 6659 90502774
Lower limb fracture 55.59 11.90 21 118993 84992 90424441
Erythema 55.52 11.90 138 118876 229108 90280325
Inappropriate affect 55.31 11.90 27 118987 998 90508435
Withdrawal syndrome 55.11 11.90 103 118911 22421 90487012
Osteoporosis 55.03 11.90 29 118985 96502 90412931
Abulia 54.92 11.90 24 118990 685 90508748
Nausea 54.51 11.90 1080 117934 1109236 89400197
Crying 53.90 11.90 110 118904 25535 90483898
Hallucination, olfactory 53.61 11.90 19 118995 305 90509128
Product availability issue 53.54 11.90 57 118957 7347 90502086
Major depression 53.52 11.90 66 118948 9969 90499464
Colitis 53.46 11.90 13 119001 69929 90439504
Headache 52.97 11.90 806 118208 861940 89647493
Liver disorder 52.55 11.90 49 118965 121220 90388213
Back pain 52.50 11.90 226 118788 316949 90192484
Somnambulism 52.37 11.90 52 118962 6176 90503257
Speech disorder 52.36 11.90 155 118859 45430 90464003
Bradykinesia 52.20 11.90 54 118960 6734 90502699
Thrombocytopenia 51.84 11.90 124 118890 208601 90300832
Soft tissue injury 51.79 11.90 33 118981 2059 90507374
Alice in wonderland syndrome 51.56 11.90 12 119002 34 90509399
Upper respiratory tract infection 50.87 11.90 56 118958 128262 90381171
Chest pain 50.35 11.90 232 118782 319413 90190020
Blood triglycerides increased 49.82 11.90 75 118939 13686 90495747
Tachycardia 49.65 11.90 366 118648 157307 90352126
Threatened labour 49.50 11.90 24 118990 874 90508559
Right ventricular false tendon 49.45 11.90 10 119004 10 90509423
Rhesus incompatibility 49.21 11.90 14 119000 104 90509329
Movement disorder 49.05 11.90 114 118900 28905 90480528
Parkinsonian gait 49.00 11.90 21 118993 571 90508862
Bankruptcy 48.99 11.90 11 119003 25 90509408
Pleurothotonus 48.59 11.90 27 118987 1308 90508125
Liver function test increased 47.63 11.90 26 118988 84829 90424604
Stereotypy 47.29 11.90 19 118995 437 90508996
Psychomotor skills impaired 46.75 11.90 35 118979 2837 90506596
Hyperhidrosis 46.75 11.90 323 118691 135982 90373451
Homicidal ideation 46.37 11.90 29 118985 1751 90507682
Psychotic behaviour 46.33 11.90 21 118993 655 90508778
Mydriasis 46.28 11.90 76 118938 14936 90494497
Post-traumatic neck syndrome 46.28 11.90 33 118981 2481 90506952
Pulmonary embolism 46.05 11.90 312 118702 130508 90378925
Antipsychotic drug level below therapeutic 45.81 11.90 17 118997 313 90509120
Foot deformity 45.76 11.90 11 119003 59640 90449793
Mucosal inflammation 45.45 11.90 10 119004 57615 90451818
Drug screen false positive 45.44 11.90 23 118991 920 90508513
Substance use disorder 45.43 11.90 30 118984 1990 90507443
Meconium aspiration syndrome 45.41 11.90 10 119004 20 90509413
Asthenia 45.34 11.90 465 118549 533286 89976147
Product administered to patient of inappropriate age 45.08 11.90 42 118972 4611 90504822
Slow response to stimuli 44.98 11.90 24 118990 1072 90508361
Immunodeficiency 44.97 11.90 3 119011 43231 90466202
Hypersomnia 44.84 11.90 92 118922 21439 90487994
Syringe issue 44.43 11.90 39 118975 3963 90505470
Disorientation 44.18 11.90 143 118871 43971 90465462
Hepatic cirrhosis 44.16 11.90 14 119000 63239 90446194
Intellectual disability 44.06 11.90 25 118989 1261 90508172
Monocyte count increased 44.03 11.90 57 118957 9040 90500393
Red blood cell sedimentation rate increased 43.95 11.90 27 118987 82568 90426865
Lupus-like syndrome 43.94 11.90 6 119008 48840 90460593
Malignant catatonia 43.50 11.90 15 118999 221 90509212
Accidental exposure to product by child 43.23 11.90 25 118989 1308 90508125
Paradoxical drug reaction 42.78 11.90 45 118969 5721 90503712
Rectal haemorrhage 42.72 11.90 28 118986 82716 90426717
Drug ineffective 42.62 11.90 2222 116792 1382076 89127357
Adjustment disorder with depressed mood 42.50 11.90 11 119003 56742 90452691
Herpes zoster 42.49 11.90 37 118977 94607 90414826
Anhedonia 42.38 11.90 63 118951 11368 90498065
Drug withdrawal syndrome 42.30 11.90 107 118907 28616 90480817
Joint stiffness 42.24 11.90 25 118989 78017 90431416
Platelet count decreased 42.00 11.90 72 118942 136897 90372536
Trismus 41.93 11.90 41 118973 4780 90504653
Illusion 41.77 11.90 24 118990 1240 90508193
Asthma 41.01 11.90 171 118843 241989 90267444
Affect lability 40.99 11.90 80 118934 17983 90491450
Resting tremor 40.99 11.90 21 118993 862 90508571
Parkinsonian rest tremor 40.37 11.90 13 119001 153 90509280
Drug monitoring procedure not performed 40.29 11.90 20 118994 767 90508666
Selective eating disorder 40.23 11.90 28 118986 2025 90507408
Hospitalisation 40.12 11.90 297 118717 127803 90381630
Newborn persistent pulmonary hypertension 40.09 11.90 15 118999 283 90509150
Sternal fracture 40.05 11.90 32 118982 2855 90506578
Oropharyngeal spasm 39.89 11.90 15 118999 287 90509146
Manic symptom 39.74 11.90 11 119003 73 90509360
Sedation complication 39.62 11.90 76 118938 16868 90492565
Generalised tonic-clonic seizure 39.44 11.90 118 118896 34785 90474648
Dyslipidaemia 39.35 11.90 57 118957 10050 90499383
Neuropathy peripheral 39.31 11.90 75 118939 136895 90372538
Conversion disorder 39.11 11.90 28 118986 2118 90507315
Emotional poverty 39.04 11.90 16 118998 388 90509045
Pleural effusion 39.00 11.90 54 118960 111937 90397496
Antipsychotic drug level decreased 38.69 11.90 16 118998 397 90509036
Post cholecystectomy syndrome 38.16 11.90 20 118994 861 90508572
Bundle branch block right 37.71 11.90 41 118973 5412 90504021
Tachyphrenia 37.55 11.90 25 118989 1681 90507752
Hyperreflexia 37.48 11.90 45 118969 6612 90502821
Product administration interrupted 36.85 11.90 62 118952 12430 90497003
Pseudomyopia 36.85 11.90 10 119004 61 90509372
Eosinophilic myocarditis 36.83 11.90 18 118996 667 90508766
Pneumonia aspiration 36.82 11.90 128 118886 40812 90468621
Atrial fibrillation 36.76 11.90 75 118939 133536 90375897
Injection site reaction 36.70 11.90 40 118974 92040 90417393
Exostosis 36.67 11.90 12 119002 53122 90456311
Food craving 36.62 11.90 26 118988 1941 90507492
Fluid retention 36.53 11.90 37 118977 88054 90421379
Premature baby 36.50 11.90 93 118921 24984 90484449
Grandiosity 35.98 11.90 14 119000 295 90509138
Ideas of reference 35.86 11.90 11 119003 109 90509324
Polyuria 35.33 11.90 54 118960 9986 90499447
Breast feeding 35.29 11.90 19 118995 864 90508569
Vomiting 35.26 11.90 778 118236 787515 89721918
Neglect of personal appearance 35.08 11.90 11 119003 118 90509315
Sepsis 34.96 11.90 120 118894 179694 90329739
Negative symptoms in schizophrenia 34.91 11.90 11 119003 120 90509313
Delusion of reference 34.67 11.90 11 119003 123 90509310
Birdshot chorioretinopathy 34.50 11.90 10 119004 80 90509353
Normal newborn 34.38 11.90 87 118927 23275 90486158
Taste disorder 34.33 11.90 19 118995 61527 90447906
Vision blurred 34.13 11.90 255 118759 110038 90399395
Multiple organ dysfunction syndrome 34.11 11.90 24 118990 68312 90441121
Electroencephalogram abnormal 34.07 11.90 34 118980 4062 90505371
Cardiac failure congestive 33.96 11.90 48 118966 98646 90410787
Breech presentation 33.91 11.90 21 118993 1246 90508187
Megacolon 33.87 11.90 26 118988 2188 90507245
Premature labour 33.77 11.90 62 118952 13314 90496119
Vitamin B12 increased 33.68 11.90 24 118990 1802 90507631
Substance-induced psychotic disorder 33.58 11.90 29 118985 2883 90506550
Neuropsychiatric symptoms 33.49 11.90 17 118997 684 90508749
Acute kidney injury 33.34 11.90 265 118749 320122 90189311
Emotional distress 33.30 11.90 115 118899 36547 90472886
Gastrointestinal haemorrhage 32.97 11.90 42 118972 90206 90419227
Exposure during pregnancy 32.92 11.90 467 118547 237943 90271490
Oromandibular dystonia 32.89 11.90 16 118998 587 90508846
Rebound psychosis 32.85 11.90 12 119002 211 90509222
Ataxia 32.85 11.90 73 118941 17969 90491464
Bladder dilatation 32.82 11.90 19 118995 996 90508437
Coeliac disease 32.73 11.90 9 119005 44601 90464832
Reduced facial expression 32.68 11.90 27 118987 2526 90506907
Ascites 32.56 11.90 11 119003 47729 90461704
Hypoprolactinaemia 32.48 11.90 7 119007 12 90509421
Suspiciousness 32.45 11.90 14 119000 387 90509046
Substance use 32.41 11.90 20 118994 1179 90508254
Plasma cell myeloma 32.37 11.90 7 119007 40821 90468612
Morbid thoughts 32.32 11.90 17 118997 737 90508696
Hepatotoxicity 32.26 11.90 10 119004 45832 90463601
Neonatal hypotension 32.22 11.90 11 119003 157 90509276
Reversible cerebral vasoconstriction syndrome 32.02 11.90 33 118981 4097 90505336
Bone marrow oedema syndrome 31.85 11.90 9 119005 65 90509368
Product substitution issue 31.82 11.90 72 118942 17936 90491497
Skin ulcer 31.70 11.90 13 119001 50062 90459371
Type 2 diabetes mellitus 31.69 11.90 148 118866 203096 90306337
Head titubation 31.38 11.90 20 118994 1248 90508185
Back injury 31.35 11.90 11 119003 46611 90462822
Congenital eye disorder 31.32 11.90 8 119006 37 90509396
Inappropriate antidiuretic hormone secretion 31.20 11.90 75 118939 19430 90490003
Sexually inappropriate behaviour 31.18 11.90 10 119004 116 90509317
Target skin lesion 31.03 11.90 10 119004 118 90509315
Distractibility 30.99 11.90 15 118999 544 90508889
Nephrogenic diabetes insipidus 30.95 11.90 18 118996 952 90508481
Neoplasm progression 30.78 11.90 10 119004 44476 90464957
Delusion of parasitosis 30.65 11.90 10 119004 123 90509310
Onychomycosis 30.48 11.90 6 119008 37370 90472063
Walking aid user 30.47 11.90 5 119009 35501 90473932
Osteonecrosis of jaw 30.41 11.90 7 119007 39096 90470337
Congenital nystagmus 30.33 11.90 8 119006 43 90509390
Granulocyte count increased 30.24 11.90 21 118993 1513 90507920
Water intoxication 30.20 11.90 15 118999 576 90508857
Malaise 30.15 11.90 565 118449 585421 89924012
Productive cough 30.13 11.90 34 118980 77029 90432404
Personal relationship issue 30.08 11.90 10 119004 131 90509302
Emotional disorder 29.96 11.90 63 118951 14934 90494499
Eating disorder 29.93 11.90 93 118921 27980 90481453
Chorioretinopathy 29.86 11.90 17 118997 863 90508570
Physical assault 29.76 11.90 17 118997 869 90508564
Tension 29.60 11.90 30 118984 3652 90505781
Electrocardiogram QRS complex prolonged 29.43 11.90 42 118972 7306 90502127
Autonomic nervous system imbalance 29.37 11.90 29 118985 3421 90506012
Choroidal coloboma 29.30 11.90 7 119007 23 90509410
Dyspnoea exertional 29.25 11.90 31 118983 72257 90437176
Taciturnity 29.19 11.90 6 119008 7 90509426
Musculoskeletal stiffness 29.15 11.90 249 118765 296283 90213150
Nuchal rigidity 29.12 11.90 16 118998 758 90508675
Hypoventilation neonatal 29.07 11.90 7 119007 24 90509409
Hereditary ataxia 29.07 11.90 7 119007 24 90509409
Drug level above therapeutic 29.06 11.90 37 118977 5772 90503661
C-reactive protein increased 28.92 11.90 131 118883 181258 90328175
Compulsive hoarding 28.91 11.90 8 119006 53 90509380
Dysphoria 28.91 11.90 38 118976 6116 90503317
Concussion 28.75 11.90 52 118962 11039 90498394
Divorced 28.75 11.90 6 119008 8 90509425
Blood immunoglobulin A increased 28.72 11.90 19 118995 1264 90508169
Gastrooesophageal reflux disease 28.43 11.90 117 118897 166220 90343213
Frequent bowel movements 28.41 11.90 20 118994 56915 90452518
Dementia with Lewy bodies 28.31 11.90 13 119001 418 90509015
Diverticulitis 28.17 11.90 12 119002 45175 90464258
Gynaecomastia 28.09 11.90 11 119003 236 90509197
Agitation neonatal 28.08 11.90 14 119000 542 90508891
Congenital hypothyroidism 28 11.90 11 119003 238 90509195
Laryngitis 27.83 11.90 16 118998 50737 90458696
Hypertension 27.79 11.90 428 118586 457104 90052329
Dependent personality disorder 27.60 11.90 8 119006 64 90509369
Melaena 27.52 11.90 6 119008 34791 90474642
Uterine dilation and curettage 27.34 11.90 17 118997 1016 90508417
Macular degeneration 27.23 11.90 8 119006 37962 90471471
Psoriasis 27.13 11.90 101 118913 147653 90361780
Drug effective for unapproved indication 27.04 11.90 42 118972 7876 90501557
Hunger 27.00 11.90 38 118976 6525 90502908
Haematochezia 26.96 11.90 32 118982 70881 90438552
Septic shock 26.95 11.90 43 118971 84117 90425316
Aspartate aminotransferase 26.93 11.90 15 118999 730 90508703
Glomerular filtration rate increased 26.82 11.90 22 118992 2038 90507395
Persistent depressive disorder 26.66 11.90 18 118996 1239 90508194
Respiratory arrest 26.44 11.90 100 118914 33211 90476222
Disorganised speech 26.38 11.90 21 118993 1864 90507569
Chemical burn 26.11 11.90 13 119001 502 90508931
Granulocytopenia 26.07 11.90 37 118977 6404 90503029
Compulsions 26.05 11.90 10 119004 203 90509230
Electric shock 25.86 11.90 20 118994 1702 90507731
Neck pain 25.74 11.90 71 118943 113892 90395541
Accommodation disorder 25.68 11.90 12 119002 402 90509031
Homeless 25.67 11.90 8 119006 84 90509349
Fear 25.61 11.90 63 118951 16559 90492874
Breast enlargement 25.52 11.90 20 118994 1735 90507698
Hypertonic bladder 25.48 11.90 30 118984 4318 90505115
Sleep deficit 25.38 11.90 16 118998 980 90508453
Colitis ulcerative 25.35 11.90 25 118989 60241 90449192
Poor feeding infant 25.34 11.90 13 119001 535 90508898
Muscle tightness 25.17 11.90 55 118959 13384 90496049
Menstruation irregular 25.11 11.90 41 118973 8019 90501414
Glycosylated haemoglobin increased 25.07 11.90 60 118954 15502 90493931
Suspected suicide 24.98 11.90 45 118969 9523 90499910
Ear infection 24.94 11.90 33 118981 69742 90439691
Respiratory disorder 24.91 11.90 29 118985 64787 90444646
Poisoning 24.87 11.90 59 118955 15158 90494275
Laboratory test abnormal 24.71 11.90 12 119002 41842 90467591
Schizophreniform disorder 24.70 11.90 8 119006 96 90509337
Inability to afford medication 24.64 11.90 27 118987 3595 90505838
Hypothyroidism 24.57 11.90 136 118878 52991 90456442
Negativism 24.40 11.90 12 119002 451 90508982
White blood cells urine positive 24.36 11.90 36 118978 6462 90502971
Panic attack 24.20 11.90 83 118931 26282 90483151
Microphthalmos 24.19 11.90 9 119005 167 90509266
Facial nerve disorder 24.13 11.90 13 119001 592 90508841
Hypotonia 24.00 11.90 49 118965 11377 90498056
Negative thoughts 23.96 11.90 16 118998 1081 90508352
Verbal abuse 23.91 11.90 8 119006 107 90509326
Obsessive-compulsive symptom 23.91 11.90 8 119006 107 90509326
Postural tremor 23.85 11.90 12 119002 474 90508959
Staphylococcal infection 23.75 11.90 126 118888 48313 90461120
Drug-induced liver injury 23.75 11.90 52 118962 90266 90419167
Blood creatine phosphokinase 23.71 11.90 9 119005 177 90509256
Floppy iris syndrome 23.45 11.90 8 119006 114 90509319
Wound complication 23.29 11.90 30 118984 4733 90504700
Choroiditis 23.26 11.90 10 119004 274 90509159
Blood prolactin decreased 23.23 11.90 7 119007 65 90509368
Hypercalcaemia 23.16 11.90 8 119006 34232 90475201
Foetal growth restriction 23.08 11.90 43 118971 9337 90500096
Ear pain 23.06 11.90 25 118989 57677 90451756
Urinary bladder rupture 23.03 11.90 9 119005 192 90509241
Body mass index decreased 22.86 11.90 12 119002 518 90508915
White blood cell count increased 22.84 11.90 159 118855 67082 90442351
Retinal coloboma 22.79 11.90 6 119008 32 90509401
Oral candidiasis 22.77 11.90 9 119005 35446 90473987
Intentional product misuse 22.73 11.90 198 118816 89406 90420027
Pneumonitis 22.73 11.90 15 118999 44155 90465278
Suicide threat 22.63 11.90 6 119008 33 90509400
Drug tolerance decreased 22.62 11.90 7 119007 32123 90477310
Biliary tract infection 22.62 11.90 14 119000 830 90508603
Psychosexual disorder 22.55 11.90 4 119010 0 90509433
Shoplifting 22.55 11.90 4 119010 0 90509433
Confusional arousal 22.45 11.90 10 119004 299 90509134
COVID-19 22.35 11.90 130 118884 168713 90340720
Intermenstrual bleeding 22.34 11.90 42 118972 9181 90500252
Drug ineffective for unapproved indication 22.29 11.90 157 118857 66487 90442946
Inhibitory drug interaction 22.25 11.90 24 118990 3139 90506294
Myocarditis septic 22.19 11.90 6 119008 36 90509397
Breath odour 22.11 11.90 17 118997 1434 90507999
Paraesthesia oral 22.11 11.90 7 119007 31652 90477781
Social problem 21.97 11.90 16 118998 1243 90508190
Decreased interest 21.93 11.90 28 118986 4379 90505054
Rash pruritic 21.89 11.90 47 118967 82167 90427266
Delusional disorder, unspecified type 21.85 11.90 11 119003 435 90508998
Palmar-plantar erythrodysaesthesia syndrome 21.82 11.90 5 119009 28018 90481415
Merycism 21.79 11.90 10 119004 321 90509112
Intention tremor 21.78 11.90 11 119003 438 90508995
Death 21.70 11.90 446 118568 456105 90053328
International normalised ratio abnormal 21.66 11.90 26 118988 3819 90505614
Drug effect less than expected 21.58 11.90 33 118981 6105 90503328
Iris coloboma 21.52 11.90 6 119008 41 90509392
Urate nephropathy 21.47 11.90 8 119006 149 90509284
Muscular weakness 21.45 11.90 171 118843 206495 90302938
Pulmonary artery stenosis congenital 21.41 11.90 11 119003 454 90508979
Cholangitis infective 21.41 11.90 11 119003 454 90508979
Abortion threatened 21.41 11.90 12 119002 591 90508842
Obsessive thoughts 21.32 11.90 12 119002 596 90508837
Anterograde amnesia 21.30 11.90 12 119002 597 90508836
Polydipsia 21.24 11.90 27 118987 4204 90505229
Gastric ulcer 21.17 11.90 5 119009 27443 90481990
Myoglobin blood increased 21.10 11.90 17 118997 1535 90507898
Abnormal dreams 21.01 11.90 46 118968 11211 90498222
Hypocalcaemia 20.98 11.90 15 118999 42353 90467080
Cholestasis of pregnancy 20.86 11.90 17 118997 1560 90507873
Protrusion tongue 20.86 11.90 10 119004 355 90509078
Full blood count abnormal 20.85 11.90 11 119003 36586 90472847
Road traffic accident 20.79 11.90 72 118942 107554 90401879
Metastases to liver 20.79 11.90 6 119008 28801 90480632
Incontinence 20.78 11.90 51 118963 13384 90496049
Femur fracture 20.70 11.90 18 118996 46064 90463369
Hypernatraemia 20.60 11.90 41 118973 9346 90500087
Basal cell carcinoma 20.60 11.90 9 119005 33380 90476053
Transient aphasia 20.59 11.90 6 119008 49 90509384
Asocial behaviour 20.58 11.90 5 119009 18 90509415
Theft 20.56 11.90 7 119007 99 90509334
Screaming 20.54 11.90 25 118989 3725 90505708
Joint dislocation 20.53 11.90 17 118997 44565 90464868
Blood pressure systolic increased 20.44 11.90 28 118986 58317 90451116
Sleep-related eating disorder 20.40 11.90 14 119000 990 90508443
Affective ambivalence 20.37 11.90 5 119009 19 90509414
Poor quality sleep 20.32 11.90 75 118939 24618 90484815
Pancytopenia 20.30 11.90 85 118929 120178 90389255
Drowning 20.28 11.90 11 119003 508 90508925
Cataract 20.22 11.90 40 118974 72052 90437381
Cytomegalovirus infection 20.22 11.90 5 119009 26597 90482836
Tongue biting 20.18 11.90 19 118995 2114 90507319
Morning sickness 20.17 11.90 14 119000 1008 90508425
Fear of weight gain 20.16 11.90 5 119009 20 90509413
Diabetic hyperosmolar coma 20.09 11.90 10 119004 386 90509047
Auditory disorder 20.04 11.90 15 118999 1215 90508218
Rheumatoid factor increased 20.03 11.90 20 118994 2391 90507042
Full blood count decreased 19.97 11.90 7 119007 29682 90479751
Twin pregnancy 19.90 11.90 15 118999 1228 90508205
Therapy non-responder 19.88 11.90 102 118912 136602 90372831
Coloboma 19.83 11.90 7 119007 111 90509322
Injection site erythema 19.64 11.90 65 118949 98437 90410996
Lethargy 19.54 11.90 146 118868 62993 90446440
Bone pain 19.53 11.90 32 118982 61951 90447482
Sleep disorder due to a general medical condition 19.47 11.90 18 118996 44720 90464713
Akinesia 19.44 11.90 17 118997 1719 90507714
Female orgasmic disorder 19.42 11.90 6 119008 61 90509372
Pulmonary valve stenosis 19.35 11.90 10 119004 418 90509015
Middle insomnia 19.27 11.90 57 118957 16694 90492739
Back disorder 19.13 11.90 5 119009 25626 90483807
Oropharyngeal pain 19.08 11.90 82 118932 115105 90394328
Haemoptysis 19 11.90 10 119004 33310 90476123
Metastases to bone 18.99 11.90 5 119009 25500 90483933
Hemiparesis 18.97 11.90 9 119005 31810 90477623
Renal failure 18.91 11.90 98 118916 130909 90378524
Dyskinesia oesophageal 18.89 11.90 4 119010 6 90509427
Pregnancy with implant contraceptive 18.88 11.90 24 118990 3737 90505696
Pre-existing condition improved 18.88 11.90 39 118975 9130 90500303
Waxy flexibility 18.61 11.90 7 119007 134 90509299
Bradycardia 18.60 11.90 180 118834 83667 90425766
Deja vu 18.56 11.90 7 119007 135 90509298
Self-medication 18.51 11.90 22 118992 3198 90506235
Muscle contractions involuntary 18.50 11.90 21 118993 2907 90506526
Balance disorder 18.48 11.90 202 118812 96878 90412555
Nodule 18.46 11.90 6 119008 26680 90482753
Mental status changes 18.45 11.90 111 118903 44568 90464865
Meningitis streptococcal 18.42 11.90 7 119007 138 90509295
Adverse reaction 18.35 11.90 8 119006 29704 90479729
Decreased activity 18.24 11.90 36 118978 8156 90501277
Social anxiety disorder 18.24 11.90 11 119003 622 90508811
Haemoglobin decreased 18.23 11.90 131 118883 161825 90347608
Heart rate 18.12 11.90 8 119006 234 90509199
Ulcer haemorrhage 18.06 11.90 6 119008 26315 90483118
Activation syndrome 18.00 11.90 8 119006 238 90509195
Staring 17.99 11.90 16 118998 1654 90507779
Adjusted calcium increased 17.96 11.90 5 119009 34 90509399
Grimacing 17.91 11.90 10 119004 489 90508944
Dry mouth 17.87 11.90 155 118859 183904 90325529
Coronary artery disease 17.87 11.90 11 119003 33612 90475821
Haematuria 17.79 11.90 12 119002 34925 90474508
Feeling guilty 17.70 11.90 11 119003 657 90508776
Drug resistance 17.61 11.90 83 118931 30366 90479067
Polyhydramnios 17.59 11.90 19 118995 2489 90506944
Abdominal distension 17.58 11.90 100 118914 130501 90378932
Obstructive airways disorder 17.57 11.90 6 119008 25863 90483570
Hepatitis 17.57 11.90 42 118972 70697 90438736
Foetal anticonvulsant syndrome 17.56 11.90 11 119003 666 90508767
Chest discomfort 17.54 11.90 108 118906 138257 90371176
Ventricular septal defect 17.52 11.90 28 118986 5379 90504054
Rash erythematous 17.52 11.90 37 118977 65067 90444366
Neutrophilia 17.47 11.90 29 118985 5749 90503684
Cerebral haemorrhage 17.39 11.90 12 119002 34510 90474923
Neonatal respiratory distress 17.38 11.90 11 119003 678 90508755
Bronchiectasis 17.36 11.90 4 119010 22326 90487107
Fibrin D dimer increased 17.32 11.90 28 118986 5432 90504001
Cross sensitivity reaction 17.22 11.90 20 118994 2837 90506596
Food allergy 17.15 11.90 6 119008 25472 90483961
Narcolepsy 17.15 11.90 15 118999 1517 90507916
Cardiac arrest 17.15 11.90 212 118802 104723 90404710
Type 1 diabetes mellitus 17.10 11.90 26 118988 4786 90504647
Epistaxis 17.09 11.90 56 118958 85069 90424364
Joint hyperextension 16.99 11.90 9 119005 396 90509037
Congenital ureteric anomaly 16.95 11.90 6 119008 96 90509337
Right ventricular systolic pressure decreased 16.93 11.90 5 119009 43 90509390
Lisfranc fracture 16.91 11.90 3 119011 0 90509433
Noninfective encephalomyelitis 16.91 11.90 3 119011 0 90509433
Living alone 16.91 11.90 3 119011 0 90509433
Pyromania 16.91 11.90 3 119011 0 90509433
Schizoaffective disorder depressive type 16.91 11.90 3 119011 0 90509433
Muscle spasticity 16.85 11.90 13 119001 35309 90474124
Pseudodementia 16.83 11.90 6 119008 98 90509335
Injection site pruritus 16.77 11.90 28 118986 53806 90455627
Chills 16.74 11.90 103 118911 131878 90377555
Developmental hip dysplasia 16.71 11.90 15 118999 1570 90507863
Therapy change 16.67 11.90 35 118979 8287 90501146
Diabetic coma 16.64 11.90 11 119003 731 90508702
Somatic symptom disorder of pregnancy 16.35 11.90 6 119008 107 90509326
Helplessness 16.31 11.90 8 119006 299 90509134
Product quality issue 16.05 11.90 52 118962 79273 90430160
Violence-related symptom 16.03 11.90 10 119004 601 90508832
Blood glucose fluctuation 16.03 11.90 26 118988 5057 90504376
Angle closure glaucoma 16.02 11.90 19 118995 2756 90506677
Polyneuropathy 15.99 11.90 3 119011 19338 90490095
Trisomy 21 15.95 11.90 9 119005 449 90508984
Polydactyly 15.87 11.90 8 119006 317 90509116
Immature respiratory system 15.83 11.90 5 119009 55 90509378
Rhinorrhoea 15.80 11.90 61 118953 88255 90421178
Somatic symptom disorder 15.78 11.90 21 118993 3420 90506013
Electroconvulsive therapy 15.75 11.90 5 119009 56 90509377
Asphyxia 15.56 11.90 31 118983 7072 90502361
Respiratory tract infection 15.54 11.90 34 118980 59044 90450389
Tooth avulsion 15.51 11.90 5 119009 59 90509374
Creatinine renal clearance decreased 15.48 11.90 3 119011 18896 90490537
Body mass index increased 15.45 11.90 14 119000 1483 90507950
Feeling of despair 15.39 11.90 20 118994 3184 90506249
Patient dissatisfaction with treatment 15.31 11.90 8 119006 342 90509091
Acute myocardial infarction 15.22 11.90 14 119000 34876 90474557
Paroxysmal perceptual alteration 15.22 11.90 5 119009 63 90509370
Diabetic ketoacidosis 15.20 11.90 68 118946 24339 90485094
Bone marrow failure 15.20 11.90 12 119002 32209 90477224
Trichotillomania 15.18 11.90 6 119008 132 90509301
Sleep apnoea syndrome 15.17 11.90 82 118932 31665 90477768
Initial insomnia 15.11 11.90 36 118978 9274 90500159
Pustular psoriasis 15.09 11.90 3 119011 18553 90490880
Motor developmental delay 15.08 11.90 7 119007 231 90509202
Urine amphetamine positive 15.07 11.90 5 119009 65 90509368
Procedural pain 15.02 11.90 13 119001 33347 90476086
Weight decreased 14.97 11.90 382 118632 379528 90129905
Delusional perception 14.96 11.90 7 119007 235 90509198
Libido decreased 14.93 11.90 19 118995 2963 90506470
Muscle spasms 14.80 11.90 237 118777 251646 90257787
Hip fracture 14.76 11.90 13 119001 33064 90476369
Pupil fixed 14.71 11.90 16 118998 2112 90507321
Maternal exposure during breast feeding 14.67 11.90 28 118986 6192 90503241
Bone disorder 14.64 11.90 6 119008 23114 90486319
Genitourinary symptom 14.58 11.90 6 119008 147 90509286
Cell death 14.56 11.90 19 118995 3036 90506397
Irregular sleep phase 14.52 11.90 4 119010 26 90509407
Kleptomania 14.52 11.90 4 119010 26 90509407
Osteopenia 14.51 11.90 6 119008 22996 90486437
Pulmonary mass 14.49 11.90 10 119004 28762 90480671
Excessive eye blinking 14.49 11.90 13 119001 1359 90508074
Product administered by wrong person 14.48 11.90 5 119009 74 90509359
Memory impairment 14.41 11.90 350 118664 196894 90312539
CYP2C19 polymorphism 14.39 11.90 4 119010 27 90509406
Disruptive mood dysregulation disorder 14.37 11.90 3 119011 4 90509429
Bicytopenia 14.29 11.90 21 118993 3750 90505683
Crystalluria 14.25 11.90 9 119005 553 90508880
Delusion of grandeur 14.23 11.90 7 119007 263 90509170
Drug dependence 14.18 11.90 76 118938 29251 90480182
Myositis 14.12 11.90 7 119007 24121 90485312
Bacillus infection 14.10 11.90 11 119003 948 90508485
Acute hepatic failure 14.05 11.90 6 119008 22555 90486878
Female sexual dysfunction 14.01 11.90 5 119009 82 90509351
Throat clearing 13.97 11.90 21 118993 3826 90505607
Humidity intolerance 13.95 11.90 8 119006 412 90509021
Metastases to central nervous system 13.92 11.90 3 119011 17539 90491894
Dysbiosis 13.92 11.90 14 119000 1688 90507745
Temperature intolerance 13.90 11.90 41 118973 11989 90497444
Gastrointestinal lymphoma 13.90 11.90 5 119009 84 90509349
Pseudomembranous colitis 13.89 11.90 21 118993 3847 90505586
Bronchitis 13.88 11.90 131 118883 152796 90356637
Dactylitis 13.87 11.90 21 118993 3852 90505581
Paralogism 13.80 11.90 4 119010 32 90509401
Product dose omission issue 13.76 11.90 490 118524 291197 90218236
Migraine 13.71 11.90 172 118842 190220 90319213
Menstrual disorder 13.70 11.90 27 118987 6111 90503322
Cast application 13.69 11.90 4 119010 33 90509400
Gastritis 13.68 11.90 21 118993 41732 90467701
Induced labour 13.62 11.90 11 119003 997 90508436
Cardiac failure 13.60 11.90 86 118928 109410 90400023
Drug withdrawal syndrome neonatal 13.59 11.90 16 118998 2303 90507130
Hyponatriuria 13.59 11.90 4 119010 34 90509399
Poriomania 13.58 11.90 5 119009 90 90509343
Spasmodic dysphonia 13.53 11.90 5 119009 91 90509342
Embolism venous 13.49 11.90 20 118994 3600 90505833
Breast discharge 13.44 11.90 12 119002 1247 90508186
Sudden death 13.40 11.90 38 118976 10871 90498562
Arachnoid cyst 13.26 11.90 7 119007 306 90509127
Food refusal 13.24 11.90 9 119005 626 90508807
Head injury 13.21 11.90 78 118936 31110 90478323
Respiratory tract congestion 13.19 11.90 10 119004 27400 90482033
Convulsive threshold lowered 13.18 11.90 8 119006 458 90508975
High density lipoprotein increased 13.12 11.90 12 119002 1286 90508147
Glucose tolerance impaired 13.09 11.90 31 118983 7954 90501479
Radiculopathy 13.09 11.90 4 119010 18501 90490932
Hypotension 13.06 11.90 537 118477 324860 90184573
Sluggishness 13.05 11.90 26 118988 5933 90503500
Delirium 13.04 11.90 201 118813 104158 90405275
Hypersomnia-bulimia syndrome 13.02 11.90 3 119011 8 90509425
Gestational hypertension 13.00 11.90 18 118996 3044 90506389
Hypoxia 12.95 11.90 50 118964 72349 90437084
Perinatal depression 12.95 11.90 10 119004 849 90508584
Haematocrit increased 12.93 11.90 18 118996 3060 90506373
Drug screen positive 12.93 11.90 20 118994 3737 90505696
Polyarthritis 12.92 11.90 4 119010 18346 90491087
Localised infection 12.91 11.90 15 118999 33547 90475886
Nystagmus 12.89 11.90 29 118985 7198 90502235
Oral herpes 12.88 11.90 15 118999 33509 90475924
Foetal malnutrition 12.87 11.90 5 119009 105 90509328
Electrocardiogram PR prolongation 12.84 11.90 10 119004 860 90508573
Lung neoplasm malignant 12.82 11.90 8 119006 24265 90485168
Product administered at inappropriate site 12.78 11.90 21 118993 4130 90505303
Drug reaction with eosinophilia and systemic symptoms 12.74 11.90 98 118916 42660 90466773
Energy increased 12.70 11.90 18 118996 3112 90506321
Dry skin 12.64 11.90 66 118948 88007 90421426
Sinus disorder 12.61 11.90 16 118998 34431 90475002
Adrenal cyst 12.61 11.90 5 119009 111 90509322
Hypoglycaemia neonatal 12.59 11.90 11 119003 1111 90508322
Somatic hallucination 12.52 11.90 3 119011 10 90509423
Bulimia nervosa 12.46 11.90 8 119006 506 90508927
Large for dates baby 12.38 11.90 8 119006 511 90508922
Chronic sinusitis 12.36 11.90 8 119006 23794 90485639
Interstitial lung disease 12.28 11.90 55 118959 76350 90433083
Bacteraemia 12.27 11.90 7 119007 22293 90487140
Blood glucose decreased 12.21 11.90 62 118952 23367 90486066
Meningism 12.16 11.90 8 119006 527 90508906
Sexually transmitted disease 12.14 11.90 6 119008 228 90509205
Panic reaction 12.08 11.90 22 118992 4695 90504738
Plagiocephaly 12.02 11.90 5 119009 126 90509307
Bifascicular block 12.02 11.90 5 119009 126 90509307
Neurological examination normal 11.99 11.90 4 119010 53 90509380
Spinal fracture 11.99 11.90 7 119007 22009 90487424
Orthostatic hypotension 11.98 11.90 95 118919 41732 90467701
Irregular sleep wake rhythm disorder 11.95 11.90 6 119008 236 90509197
Drug metabolising enzyme decreased 11.91 11.90 3 119011 13 90509420

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Akathisia 1883.00 13.93 734 86796 9717 42524088
Neuroleptic malignant syndrome 1410.87 13.93 746 86784 20726 42513079
Extrapyramidal disorder 1259.24 13.93 633 86897 15779 42518026
Psychotic disorder 1255.60 13.93 769 86761 28439 42505366
Sedation 1011.74 13.93 682 86848 29793 42504012
Tardive dyskinesia 959.84 13.93 403 87127 6521 42527284
Dystonia 942.08 13.93 480 87050 12310 42521495
Hallucination, auditory 843.95 13.93 469 87061 14395 42519410
Weight increased 789.69 13.93 1038 86492 106945 42426860
Delusion 705.41 13.93 416 87114 14318 42519487
Suicide attempt 687.12 13.93 644 86886 45456 42488349
Parkinsonism 638.23 13.93 348 87182 10275 42523530
Gambling disorder 632.90 13.93 207 87323 1569 42532236
Treatment noncompliance 609.37 13.93 551 86979 37121 42496684
Suicidal ideation 600.17 13.93 610 86920 47551 42486254
Aggression 573.43 13.93 572 86958 43591 42490214
Dyskinesia 525.95 13.93 428 87102 24962 42508843
Product use in unapproved indication 519.40 13.93 1159 86371 183297 42350508
Schizophrenia 510.52 13.93 300 87230 10250 42523555
Psychotic symptom 455.50 13.93 175 87355 2215 42531590
Mania 450.98 13.93 277 87253 10270 42523535
Sexual dysfunction 407.06 13.93 222 87308 6553 42527252
Hyperprolactinaemia 406.57 13.93 156 87374 1967 42531838
Agitation 401.06 13.93 573 86957 63741 42470064
Obsessive-compulsive disorder 391.47 13.93 216 87314 6527 42527278
Salivary hypersecretion 384.73 13.93 254 87276 10689 42523116
Restlessness 359.65 13.93 368 87162 28881 42504924
Blood creatine phosphokinase increased 339.24 13.93 456 87074 47882 42485923
Febrile neutropenia 332.15 13.93 11 87519 185692 42348113
Irritability 331.60 13.93 346 87184 27782 42506023
Antipsychotic drug level below therapeutic 325.69 13.93 150 87380 3054 42530751
Catatonia 319.25 13.93 184 87346 6055 42527750
Disinhibition 309.60 13.93 154 87376 3741 42530064
Anaemia 294.93 13.93 104 87426 280174 42253631
Hypersexuality 293.82 13.93 116 87414 1586 42532219
Blood prolactin abnormal 285.42 13.93 100 87430 955 42532850
Dyspnoea 273.03 13.93 305 87225 442316 42091489
Muscle rigidity 272.47 13.93 214 87316 11845 42521960
Oculogyric crisis 269.09 13.93 110 87420 1655 42532150
Apathy 268.83 13.93 184 87346 8222 42525583
Increased appetite 268.51 13.93 188 87342 8718 42525087
Diarrhoea 263.58 13.93 337 87193 460512 42073293
Euphoric mood 244.49 13.93 157 87373 6296 42527509
Pneumonia 237.87 13.93 312 87218 421837 42111968
Emotional poverty 237.67 13.93 79 87451 633 42533172
Abnormal behaviour 237.07 13.93 282 87248 26169 42507636
Paranoia 236.17 13.93 210 87320 13816 42519989
Anxiety 232.68 13.93 650 86880 117910 42415895
Persecutory delusion 225.83 13.93 121 87409 3443 42530362
Therapeutic product effect variable 221.03 13.93 114 87416 2995 42530810
Obesity 216.77 13.93 215 87315 16244 42517561
Social avoidant behaviour 215.38 13.93 115 87415 3249 42530556
Underdose 212.67 13.93 214 87316 16452 42517353
Drug ineffective 212.49 13.93 2096 85434 628101 41905704
Serotonin syndrome 211.24 13.93 263 87267 25582 42508223
Priapism 201.94 13.93 139 87391 6268 42527537
Tremor 197.63 13.93 539 86991 96390 42437415
Anosognosia 197.35 13.93 76 87454 968 42532837
Intentional self-injury 197.28 13.93 197 87333 15005 42518800
Mental impairment 188.90 13.93 175 87355 12142 42521663
Foetal exposure during pregnancy 187.15 13.93 343 87187 46968 42486837
Malignant neoplasm progression 185.00 13.93 9 87521 108391 42425414
Somnolence 177.98 13.93 665 86865 140440 42393365
Psychomotor hyperactivity 176.45 13.93 160 87370 10798 42523007
Tic 174.09 13.93 89 87441 2294 42531511
Sedation complication 173.53 13.93 95 87435 2824 42530981
Schizoaffective disorder 168.82 13.93 82 87448 1888 42531917
Drug interaction 161.46 13.93 1018 86512 265981 42267824
Acute kidney injury 160.19 13.93 321 87209 367016 42166789
Prescribed overdose 159.47 13.93 163 87367 12764 42521041
Affective disorder 157.17 13.93 116 87414 5844 42527961
Disturbance in social behaviour 151.36 13.93 74 87456 1729 42532076
Sepsis 148.85 13.93 115 87415 199219 42334586
Metabolic disorder 148.83 13.93 103 87427 4685 42529120
Psychiatric decompensation 145.95 13.93 97 87433 4125 42529680
Compulsive shopping 145.34 13.93 49 87481 412 42533393
Depressed mood 145.07 13.93 208 87322 23176 42510629
Myocarditis 142.53 13.93 185 87345 18753 42515052
Psychiatric symptom 140.75 13.93 95 87435 4146 42529659
Cough 140.43 13.93 97 87433 178006 42355799
Homicidal ideation 139.21 13.93 81 87449 2713 42531092
Pyrexia 133.37 13.93 393 87137 393649 42140156
Electrocardiogram QT prolonged 132.93 13.93 300 87230 47645 42486160
Gambling 132.27 13.93 38 87492 174 42533631
Overdose 129.23 13.93 492 87038 104772 42429033
Delusional disorder, persecutory type 128.99 13.93 42 87488 313 42533492
Arthralgia 127.64 13.93 140 87390 205098 42328707
Insomnia 126.95 13.93 530 87000 117723 42416082
Torticollis 126.43 13.93 60 87470 1310 42532495
Pruritus 126.19 13.93 121 87409 188650 42345155
Thinking abnormal 126.10 13.93 110 87420 7051 42526754
Hypomania 125.73 13.93 73 87457 2435 42531370
Pain 125.58 13.93 193 87337 244655 42289150
Death 125.24 13.93 521 87009 470664 42063141
Blood prolactin increased 123.52 13.93 70 87460 2228 42531577
Hallucination 122.34 13.93 325 87205 57182 42476623
Bruxism 121.82 13.93 68 87462 2101 42531704
Antipsychotic drug level increased 121.21 13.93 90 87440 4576 42529229
Drooling 120.91 13.93 87 87443 4212 42529593
Asthenia 120.86 13.93 247 87283 280546 42253259
Disease progression 118.96 13.93 74 87456 143582 42390223
Compulsive sexual behaviour 117.79 13.93 37 87493 242 42533563
Delusion of grandeur 116.00 13.93 64 87466 1932 42531873
Atrial fibrillation 115.46 13.93 72 87458 139521 42394284
Loss of libido 114.58 13.93 74 87456 2996 42530809
Rhabdomyolysis 113.03 13.93 385 87145 77634 42456171
Refusal of treatment by patient 111.18 13.93 90 87440 5201 42528604
Pain in extremity 109.71 13.93 89 87441 150515 42383290
Infection 105.54 13.93 49 87481 112019 42421786
Hypotension 104.68 13.93 234 87296 257397 42276408
Anger 103.99 13.93 131 87399 12887 42520918
Intentional overdose 103.62 13.93 285 87245 51171 42482634
Oedema peripheral 102.15 13.93 78 87452 135998 42397807
General physical health deterioration 100.98 13.93 97 87433 151149 42382656
Libido increased 100.06 13.93 46 87484 932 42532873
Mental disorder 99.77 13.93 152 87378 17877 42515928
Pleural effusion 98.67 13.93 38 87492 97128 42436677
Interstitial lung disease 97.46 13.93 21 87509 78441 42455364
Renal failure 96.15 13.93 92 87438 143634 42390171
Hypoprolactinaemia 95.84 13.93 19 87511 3 42533802
Ascites 95.73 13.93 5 87525 56673 42477132
Cogwheel rigidity 94.49 13.93 54 87476 1747 42532058
Oppositional defiant disorder 88.39 13.93 36 87494 536 42533269
Rash 88.00 13.93 284 87246 276670 42257135
Septic shock 87.99 13.93 39 87491 91633 42442172
Back pain 87.76 13.93 97 87433 141679 42392126
Libido decreased 87.14 13.93 77 87453 5021 42528784
Gastrointestinal haemorrhage 85.60 13.93 47 87483 97679 42436126
Dystonic tremor 85.31 13.93 31 87499 332 42533473
Completed suicide 84.40 13.93 407 87123 96058 42437747
Abdominal pain 84.03 13.93 165 87365 190306 42343499
Antipsychotic drug level decreased 82.66 13.93 43 87487 1150 42532655
Trismus 82.56 13.93 59 87471 2825 42530980
Infusion related reaction 82.54 13.93 13 87517 60793 42473012
Tachycardia 81.70 13.93 417 87113 100670 42433135
Pancytopenia 81.54 13.93 73 87457 117670 42416135
Depression 81.53 13.93 447 87083 110916 42422889
Prescribed underdose 81.38 13.93 103 87427 10179 42523626
Plasma cell myeloma 80.98 13.93 4 87526 47574 42486231
Personality change 79.56 13.93 77 87453 5642 42528163
Joint swelling 78.98 13.93 21 87509 68001 42465804
Neutrophil count increased 77.53 13.93 143 87387 19661 42514144
Gynaecomastia 76.78 13.93 111 87419 12456 42521349
Drug abuse 76.32 13.93 420 87110 104351 42429454
Therapeutic product effect incomplete 75.31 13.93 317 87213 70622 42463183
Cardiac failure congestive 75.22 13.93 41 87489 85561 42448244
Economic problem 73.80 13.93 46 87484 1749 42532056
Hospitalisation 73.42 13.93 325 87205 74005 42459800
Rhinalgia 72.66 13.93 46 87484 1798 42532007
Drug dependence 71.81 13.93 174 87356 28920 42504885
Coronary artery disease 71.76 13.93 12 87518 53708 42480097
Product administered to patient of inappropriate age 71.75 13.93 67 87463 4694 42529111
Victim of child abuse 71.51 13.93 39 87491 1150 42532655
Drug monitoring procedure incorrectly performed 70.60 13.93 27 87503 337 42533468
Breech presentation 70.45 13.93 23 87507 173 42533632
Multiple organ dysfunction syndrome 69.81 13.93 58 87472 96977 42436828
Blood triglycerides increased 68.90 13.93 120 87410 15776 42518029
Epidural lipomatosis 68.68 13.93 44 87486 1756 42532049
Hyperkalaemia 68.58 13.93 40 87490 80418 42453387
Choreoathetosis 68.43 13.93 37 87493 1072 42532733
International normalised ratio increased 68.39 13.93 9 87521 48159 42485646
Impulsive behaviour 68.02 13.93 49 87481 2376 42531429
Leukopenia 68.00 13.93 319 87211 74427 42459378
Decreased eye contact 67.66 13.93 29 87501 494 42533311
Tongue movement disturbance 67.56 13.93 21 87509 132 42533673
Poor personal hygiene 67.17 13.93 26 87504 336 42533469
Dysarthria 66.23 13.93 206 87324 39601 42494204
Leukaemia 66.18 13.93 70 87460 5702 42528103
Disturbance in sexual arousal 65.63 13.93 21 87509 147 42533658
Delirium 65.63 13.93 247 87283 52272 42481533
Lymphocyte count abnormal 65.52 13.93 46 87484 2141 42531664
Nausea 65.01 13.93 513 87017 396286 42137519
Substance use 64.83 13.93 42 87488 1709 42532096
Self-injurious ideation 64.76 13.93 43 87487 1825 42531980
Haematochezia 64.23 13.93 20 87510 58416 42475389
Prostate cancer 64.21 13.93 8 87522 44635 42489170
Cardiac failure 64.04 13.93 75 87455 106781 42427024
Respiratory failure 63.68 13.93 103 87427 128029 42405776
Erythema 61.38 13.93 80 87450 108713 42425092
Myelosuppression 61.36 13.93 6 87524 40455 42493350
Renal impairment 61.22 13.93 82 87448 110146 42423659
Blepharospasm 61.20 13.93 37 87493 1331 42532474
Colitis 60.89 13.93 11 87519 46561 42487244
Paradoxical drug reaction 60.72 13.93 61 87469 4677 42529128
Thrombocytopenia 60.44 13.93 195 87335 190084 42343721
Dyslipidaemia 60.20 13.93 85 87445 9333 42524472
Blood prolactin decreased 60.10 13.93 22 87508 241 42533564
Rheumatoid arthritis 60.09 13.93 8 87522 42432 42491373
Psychosexual disorder 59.50 13.93 19 87511 132 42533673
Myocardial infarction 59.48 13.93 102 87428 123907 42409898
Inappropriate schedule of product administration 59.17 13.93 368 87162 95534 42438271
Hallucinations, mixed 58.94 13.93 52 87478 3383 42530422
Ventricular septal defect 58.90 13.93 58 87472 4341 42529464
Spasmodic dysphonia 58.03 13.93 26 87504 495 42533310
Hypothermia 57.56 13.93 97 87433 12418 42521387
Chills 57.47 13.93 65 87465 94001 42439804
Haemoglobin decreased 57.31 13.93 116 87414 132355 42401450
Affect lability 57.29 13.93 55 87475 3989 42529816
Drug hypersensitivity 57.19 13.93 72 87458 99317 42434488
Psychomotor retardation 57.04 13.93 57 87473 4342 42529463
Multiple drug therapy 56.96 13.93 33 87497 1096 42532709
Lactic acidosis 56.42 13.93 12 87518 45249 42488556
Urticaria 56.08 13.93 42 87488 73994 42459811
Stomatitis 55.72 13.93 17 87513 50312 42483493
Juvenile idiopathic arthritis 55.68 13.93 45 87485 2594 42531211
Antidepressant drug level above therapeutic 55.58 13.93 21 87509 253 42533552
Substance dependence 55.06 13.93 27 87503 635 42533170
Wheezing 54.65 13.93 22 87508 54759 42479046
Coma 54.26 13.93 236 87294 53318 42480487
Pneumonitis 54.23 13.93 10 87520 41708 42492097
Impulse-control disorder 53.99 13.93 36 87494 1539 42532266
Disturbance in attention 53.85 13.93 159 87371 29707 42504098
Muscle twitching 53.78 13.93 91 87439 11689 42522116
Dyspnoea exertional 53.63 13.93 18 87512 50130 42483675
Haematuria 53.27 13.93 26 87504 57773 42476032
Neurodegenerative disorder 53.12 13.93 23 87507 402 42533403
Infantile vomiting 52.98 13.93 16 87514 90 42533715
Child abuse 52.93 13.93 29 87501 863 42532942
Abdominal distension 52.68 13.93 42 87488 71693 42462112
Speech disorder 52.47 13.93 155 87375 28966 42504839
Seizure 52.40 13.93 425 87105 120136 42413669
Haemoptysis 52.19 13.93 15 87515 46152 42487653
Toxicity to various agents 52.11 13.93 708 86822 228428 42305377
Analgesic drug level above therapeutic 51.72 13.93 21 87509 310 42533495
Blood creatinine increased 51.36 13.93 92 87438 109911 42423894
Social anxiety disorder 51.25 13.93 25 87505 581 42533224
Keratoconus 50.84 13.93 17 87513 139 42533666
Autism spectrum disorder 50.80 13.93 45 87485 2943 42530862
Arthritis 50.73 13.93 12 87518 42053 42491752
Homosexuality 50.65 13.93 14 87516 54 42533751
Sinusitis 50.53 13.93 17 87513 47275 42486530
Chronic kidney disease 50.45 13.93 17 87513 47224 42486581
Musculoskeletal pain 50.41 13.93 5 87525 33335 42500470
Water intoxication 50.12 13.93 22 87508 398 42533407
Urinary tract infection 50.08 13.93 79 87451 99205 42434600
Mydriasis 50.02 13.93 75 87455 8695 42525110
Tension 49.85 13.93 41 87489 2423 42531382
Hypoxia 49.83 13.93 42 87488 69744 42464061
Sinus tachycardia 49.35 13.93 122 87408 20531 42513274
Sudden cardiac death 49.33 13.93 50 87480 3874 42529931
Hiccups 49.04 13.93 89 87441 12082 42521723
Hallucination, visual 49.00 13.93 123 87407 20897 42512908
Melaena 48.86 13.93 10 87520 38736 42495069
Fatigue 48.84 13.93 617 86913 435024 42098781
Bradyphrenia 48.61 13.93 57 87473 5205 42528600
Substance-induced psychotic disorder 48.11 13.93 43 87487 2846 42530959
Paroxysmal perceptual alteration 48.00 13.93 18 87512 212 42533593
Oromandibular dystonia 47.90 13.93 24 87506 592 42533213
Tongue biting 47.60 13.93 29 87501 1058 42532747
Crying 47.38 13.93 62 87468 6332 42527473
Headache 47.20 13.93 293 87237 239076 42294729
Homeless 46.85 13.93 11 87519 17 42533788
Anxiolytic therapy 46.46 13.93 13 87517 53 42533752
Galactorrhoea 46.24 13.93 22 87508 483 42533322
Rectal haemorrhage 46.19 13.93 22 87508 49584 42484221
Respiratory depression 45.66 13.93 112 87418 18756 42515049
Decreased appetite 45.40 13.93 223 87307 192914 42340891
Acute myocardial infarction 45.35 13.93 32 87498 58133 42475672
Paraphilia 45.32 13.93 14 87516 86 42533719
Mood altered 45.27 13.93 80 87450 10638 42523167
Neuropathy peripheral 45.06 13.93 88 87442 101765 42432040
Drug therapy enhancement 44.82 13.93 13 87517 62 42533743
Sexually inappropriate behaviour 44.73 13.93 23 87507 600 42533205
Metabolic syndrome 44.37 13.93 35 87495 1948 42531857
Hostility 44.33 13.93 25 87505 788 42533017
Wrong technique in product usage process 44.04 13.93 189 87341 42446 42491359
Acute psychosis 43.98 13.93 36 87494 2113 42531692
Upper respiratory tract infection 43.62 13.93 16 87514 42157 42491648
Intentional product misuse 43.61 13.93 246 87284 61654 42472151
Antipsychotic drug level above therapeutic 43.17 13.93 29 87501 1255 42532550
Cerebrovascular accident 42.94 13.93 84 87446 97076 42436729
Loss of employment 42.82 13.93 21 87509 494 42533311
Withdrawal syndrome 42.66 13.93 94 87436 14681 42519124
Physical assault 42.66 13.93 27 87503 1055 42532750
Bronchitis 42.34 13.93 22 87508 47179 42486626
Bradykinesia 42.30 13.93 54 87476 5382 42528423
Bipolar disorder 42.21 13.93 46 87484 3876 42529929
Hyperthermia 42.11 13.93 85 87445 12489 42521316
Heat stroke 42.07 13.93 27 87503 1081 42532724
Exhibitionism 41.94 13.93 12 87518 54 42533751
Male sexual dysfunction 41.87 13.93 19 87511 373 42533432
Social problem 41.76 13.93 28 87502 1208 42532597
Dependence 41.73 13.93 30 87500 1450 42532355
Sudden death 41.62 13.93 100 87430 16529 42517276
Exposure via breast milk 41.51 13.93 37 87493 2440 42531365
Hypokalaemia 41.20 13.93 52 87478 71669 42462136
Imprisonment 41.18 13.93 22 87508 622 42533183
Thrombosis 41.13 13.93 48 87482 68463 42465342
Peripheral swelling 40.80 13.93 77 87453 90193 42443612
Erectile dysfunction 40.58 13.93 128 87402 24785 42509020
Product availability issue 40.44 13.93 43 87487 3524 42530281
Diabetic ketoacidosis 40.24 13.93 119 87411 22248 42511557
Foetal disorder 40.24 13.93 26 87504 1053 42532752
Haemorrhage 40.19 13.93 39 87491 60524 42473281
Hyperreflexia 40.04 13.93 43 87487 3564 42530241
Fall 39.80 13.93 300 87230 234220 42299585
Therapy change 38.90 13.93 45 87485 4050 42529755
Epistaxis 38.86 13.93 48 87482 66778 42467027
Oscillopsia 38.76 13.93 16 87514 247 42533558
Bankruptcy 38.69 13.93 9 87521 13 42533792
Premature baby 38.67 13.93 120 87410 23033 42510772
Blunted affect 38.52 13.93 18 87512 379 42533426
Electrocardiogram QT shortened 38.44 13.93 14 87516 151 42533654
Anaphylactic reaction 38.22 13.93 20 87510 42723 42491082
Obsessive thoughts 37.85 13.93 23 87507 835 42532970
Pleurothotonus 37.51 13.93 26 87504 1185 42532620
Posture abnormal 37.07 13.93 35 87495 2486 42531319
Symptom recurrence 37.05 13.93 28 87502 1462 42532343
Productive cough 36.85 13.93 31 87499 51536 42482269
Type 2 diabetes mellitus 36.85 13.93 102 87428 18369 42515436
Cerebral haemorrhage 36.71 13.93 17 87513 38949 42494856
Neglect of personal appearance 36.60 13.93 17 87513 353 42533452
Cholestasis 36.58 13.93 11 87519 32868 42500937
Feeling guilty 36.42 13.93 17 87513 357 42533448
Enuresis 36.36 13.93 36 87494 2712 42531093
Hypervolaemia 36.22 13.93 3 87527 23122 42510683
Sopor 35.88 13.93 82 87448 13120 42520685
Gout 35.88 13.93 7 87523 28048 42505757
Haematoma 35.82 13.93 7 87523 28016 42505789
Head titubation 35.67 13.93 18 87512 451 42533354
Dysgeusia 35.31 13.93 13 87517 34176 42499629
Gaze palsy 35.03 13.93 30 87500 1875 42531930
Incorrect dose administered 35.01 13.93 207 87323 52767 42481038
Chronic obstructive pulmonary disease 34.98 13.93 47 87483 63067 42470738
Staphylococcal infection 34.58 13.93 17 87513 37626 42496179
Hallucination, tactile 34.57 13.93 19 87511 569 42533236
Swelling 34.53 13.93 37 87493 54848 42478957
Poisoning deliberate 34.53 13.93 69 87461 10065 42523740
Postictal psychosis 34.46 13.93 14 87516 207 42533598
Cardiogenic shock 34.44 13.93 15 87515 35625 42498180
Altered state of consciousness 34.40 13.93 135 87395 29124 42504681
Activation syndrome 34.38 13.93 13 87517 157 42533648
Hyperphagia 34.23 13.93 28 87502 1642 42532163
Troponin T increased 34.18 13.93 35 87495 2745 42531060
Mycobacterial peritonitis 34.15 13.93 13 87517 160 42533645
Upper gastrointestinal haemorrhage 33.96 13.93 10 87520 30289 42503516
Neutropenia neonatal 33.90 13.93 22 87508 898 42532907
Granulocytopenia 33.87 13.93 56 87474 7058 42526747
Insurance issue 33.79 13.93 42 87488 4074 42529731
Influenza 33.75 13.93 47 87483 62128 42471677
Neuralgia 33.65 13.93 6 87524 25641 42508164
Product prescribing error 33.60 13.93 124 87406 25988 42507817
Abdominal pain upper 33.48 13.93 75 87455 82534 42451271
Pseudomyopia 33.44 13.93 11 87519 85 42533720
Musculoskeletal stiffness 33.34 13.93 218 87312 57547 42476258
Urinary incontinence 33.17 13.93 109 87421 21559 42512246
Myelodysplastic syndrome 32.89 13.93 4 87526 22741 42511064
Rash maculo-papular 32.87 13.93 18 87512 37485 42496320
Negative symptoms in schizophrenia 32.47 13.93 11 87519 94 42533711
Polydipsia 32.45 13.93 43 87487 4445 42529360
Dry skin 32.22 13.93 31 87499 48307 42485498
Herpes zoster 32.18 13.93 20 87510 38857 42494948
Depressed level of consciousness 32.05 13.93 188 87342 47782 42486023
Pneumothorax 32.02 13.93 5 87525 23538 42510267
Feeling abnormal 31.93 13.93 249 87281 69537 42464268
Sleep disorder 31.82 13.93 188 87342 47907 42485898
Somatic hallucination 31.73 13.93 9 87521 39 42533766
Mycobacterium fortuitum infection 31.70 13.93 16 87514 401 42533404
Nicotine dependence 31.66 13.93 19 87511 674 42533131
Off label use 31.47 13.93 1606 85924 636729 41897076
Muscle contractions involuntary 31.37 13.93 29 87501 2005 42531800
Staring 31.31 13.93 26 87504 1557 42532248
Diabetes mellitus 31.24 13.93 221 87309 59866 42473939
Accidental death 31.18 13.93 35 87495 3048 42530757
Schizophreniform disorder 31.01 13.93 10 87520 72 42533733
COVID-19 pneumonia 30.77 13.93 4 87526 21609 42512196
Soliloquy 30.71 13.93 18 87512 611 42533194
Stereotypy 30.69 13.93 20 87510 822 42532983
Basilar artery occlusion 30.43 13.93 10 87520 77 42533728
Patient restraint 30.43 13.93 10 87520 77 42533728
Frequent bowel movements 30.38 13.93 4 87526 21403 42512402
Nervousness 30.30 13.93 78 87452 13454 42520351
Weight decreased 30.27 13.93 277 87253 207671 42326134
Clostridium difficile colitis 30.09 13.93 4 87526 21248 42512557
Abdominal discomfort 29.95 13.93 69 87461 75186 42458619
Dopamine dysregulation syndrome 29.58 13.93 17 87513 556 42533249
Delusional disorder, unspecified type 29.57 13.93 19 87511 762 42533043
Skin ulcer 29.53 13.93 8 87522 25593 42508212
Hypophosphataemia 29.52 13.93 4 87526 20941 42512864
Poor quality sleep 29.48 13.93 62 87468 9378 42524427
Lung disorder 29.38 13.93 33 87497 47890 42485915
Coordination abnormal 28.86 13.93 56 87474 7994 42525811
Foetal distress syndrome 28.86 13.93 22 87508 1164 42532641
Therapy cessation 28.77 13.93 100 87430 20350 42513455
Colitis ulcerative 28.68 13.93 9 87521 26166 42507639
Bacteraemia 28.55 13.93 8 87522 25032 42508773
Oedema 28.53 13.93 39 87491 51962 42481843
Intentional product use issue 28.47 13.93 66 87464 71767 42462038
Negative thoughts 28.42 13.93 18 87512 704 42533101
Emotional distress 28.36 13.93 85 87445 16008 42517797
COVID-19 28.31 13.93 132 87398 115816 42417989
Blood pressure systolic increased 28.27 13.93 11 87519 27957 42505848
Hunger 28.09 13.93 27 87503 1961 42531844
Antisocial behaviour 28.08 13.93 15 87515 424 42533381
Reversible cerebral vasoconstriction syndrome 28.02 13.93 18 87512 722 42533083
Arthropathy 27.75 13.93 13 87517 29584 42504221
Compulsive hoarding 27.74 13.93 7 87523 17 42533788
Maternal exposure during breast feeding 27.60 13.93 24 87506 1531 42532274
Mood swings 27.60 13.93 58 87472 8768 42525037
Restless legs syndrome 27.56 13.93 61 87469 9553 42524252
Sleep-related eating disorder 27.48 13.93 14 87516 358 42533447
Muscle contracture 27.21 13.93 23 87507 1412 42532393
Dysphoria 27.16 13.93 31 87499 2749 42531056
Tachyphrenia 27.15 13.93 23 87507 1416 42532389
Subdural haematoma 27.12 13.93 7 87523 23131 42510674
Pulmonary valve incompetence 27.04 13.93 21 87509 1142 42532663
Self-destructive behaviour 27.03 13.93 14 87516 371 42533434
Rash pruritic 26.84 13.93 18 87512 33585 42500220
Accommodation disorder 26.73 13.93 13 87517 300 42533505
Nasopharyngitis 26.68 13.93 86 87444 83910 42449895
Drug withdrawal syndrome neonatal 26.66 13.93 39 87491 4422 42529383
Electrocardiogram QRS complex prolonged 26.60 13.93 45 87485 5778 42528027
Full blood count decreased 26.56 13.93 5 87525 20555 42513250
Inability to afford medication 26.52 13.93 27 87503 2103 42531702
Compulsions 26.52 13.93 12 87518 234 42533571
Emotional disorder 26.50 13.93 47 87483 6267 42527538
Movement disorder 26.25 13.93 78 87452 14620 42519185
Hypoglycaemia 26.21 13.93 52 87478 59802 42474003
Psoriasis 26.12 13.93 37 87493 48567 42485238
Drug effective for unapproved indication 26.09 13.93 48 87482 6585 42527220
Suicidal behaviour 25.72 13.93 23 87507 1523 42532282
Ventricular fibrillation 25.62 13.93 15 87515 30108 42503697
Stupor 25.61 13.93 32 87498 3121 42530684
Rebound psychosis 25.42 13.93 11 87519 192 42533613
Hypokinesia 25.39 13.93 60 87470 9811 42523994
Dementia 25.32 13.93 83 87447 16397 42517408
Nephrolithiasis 25.27 13.93 23 87507 36807 42496998
Non-high-density lipoprotein cholesterol increased 25.26 13.93 11 87519 195 42533610
Fluid retention 25.17 13.93 17 87513 31602 42502203
Alcohol abuse 25.08 13.93 36 87494 4013 42529792
Hyperkinesia 25.05 13.93 26 87504 2072 42531733
Eye movement disorder 25.00 13.93 40 87490 4905 42528900
Depressive symptom 24.96 13.93 35 87495 3818 42529987
Blood cholesterol increased 24.94 13.93 115 87415 26626 42507179
Malignant catatonia 24.72 13.93 14 87516 445 42533360
Diverticulitis 24.65 13.93 8 87522 22765 42511040
Bladder cancer 24.64 13.93 3 87527 17044 42516761
Faeces discoloured 24.58 13.93 3 87527 17011 42516794
Hypomagnesaemia 24.50 13.93 14 87516 28474 42505331
Candida infection 24.46 13.93 7 87523 21603 42512202
Transient ischaemic attack 24.45 13.93 20 87510 33719 42500086
Skin exfoliation 23.99 13.93 30 87500 41523 42492282
Eosinophil count decreased 23.94 13.93 33 87497 3543 42530262
Reduced facial expression 23.92 13.93 22 87508 1511 42532294
Dehydration 23.71 13.93 182 87348 141585 42392220
Encephalopathy 23.70 13.93 30 87500 41303 42492502
Rebound effect 23.67 13.93 49 87481 7330 42526475
Cataract 23.63 13.93 17 87513 30587 42503218
Theft 23.61 13.93 11 87519 230 42533575
Cognitive disorder 23.53 13.93 135 87395 34037 42499768
Hyperaldosteronism 23.52 13.93 11 87519 232 42533573
Hypometabolism 23.40 13.93 10 87520 169 42533636
Asthma 23.32 13.93 59 87471 62255 42471550
Hypoacusis 23.22 13.93 5 87525 18697 42515108
Megacolon 23.21 13.93 26 87504 2259 42531546
Product substitution issue 23.17 13.93 63 87467 11227 42522578
Diabetic coma 23.11 13.93 18 87512 983 42532822
Pulmonary fibrosis 23.10 13.93 13 87517 26668 42507137
Fungal infection 23.05 13.93 6 87524 19716 42514089
Excessive masturbation 22.93 13.93 9 87521 121 42533684
Iatrogenic injury 22.88 13.93 17 87513 865 42532940
Oxygen saturation decreased 22.87 13.93 63 87467 64624 42469181
Blood thyroid stimulating hormone decreased 22.86 13.93 26 87504 2297 42531508
Behaviour disorder 22.81 13.93 47 87483 7007 42526798
Anaphylactic shock 22.56 13.93 10 87520 23507 42510298
Gastrooesophageal reflux disease 22.52 13.93 36 87494 44987 42488818
Activated partial thromboplastin time prolonged 22.50 13.93 3 87527 15900 42517905
Skin lesion 22.46 13.93 14 87516 27160 42506645
Flat affect 22.40 13.93 18 87512 1029 42532776
Lethargy 22.38 13.93 169 87361 46721 42487084
Ejaculation disorder 22.38 13.93 18 87512 1030 42532775
High-grade B-cell lymphoma 22.38 13.93 10 87520 189 42533616
Moaning 22.26 13.93 17 87513 902 42532903
Bacterial infection 22.17 13.93 15 87515 27864 42505941
Pneumonia bacterial 22.11 13.93 3 87527 15689 42518116
Red cell distribution width decreased 21.78 13.93 11 87519 276 42533529
Adrenal insufficiency 21.66 13.93 6 87524 18918 42514887
Gangrene neonatal 21.64 13.93 10 87520 205 42533600
Accidental exposure to product by child 21.61 13.93 21 87509 1546 42532259
Gaming disorder 21.59 13.93 5 87525 7 42533798
Nephrogenic diabetes insipidus 21.53 13.93 21 87509 1553 42532252
Tubulointerstitial nephritis 21.29 13.93 20 87510 31528 42502277
Angioedema 21.21 13.93 34 87496 42443 42491362
Urinary retention 21.20 13.93 154 87376 42060 42491745
Polyneuropathy 21.20 13.93 6 87524 18655 42515150
Blood glucose increased 21.13 13.93 238 87292 73461 42460344
Pyramidal tract syndrome 21.12 13.93 11 87519 295 42533510
Flushing 21.10 13.93 27 87503 37001 42496804
Slow speech 21.04 13.93 22 87508 1768 42532037
SARS-CoV-2 test positive 21.02 13.93 50 87480 8210 42525595
Appendicitis 21.01 13.93 8 87522 20605 42513200
Muscular weakness 21.00 13.93 94 87436 83404 42450401
Mutism 20.93 13.93 20 87510 1442 42532363
Obsessive-compulsive symptom 20.92 13.93 10 87520 222 42533583
Disorientation 20.79 13.93 137 87393 36252 42497553
Hepatotoxicity 20.75 13.93 13 87517 25154 42508651
Energy increased 20.64 13.93 20 87510 1467 42532338
Substance abuse 20.64 13.93 52 87478 8853 42524952
Anamnestic reaction 20.54 13.93 7 87523 61 42533744
Metastases to bone 20.47 13.93 3 87527 14806 42518999
Thrombotic microangiopathy 20.42 13.93 3 87527 14779 42519026
Neutropenic sepsis 20.34 13.93 4 87526 15942 42517863
Impaired healing 20.29 13.93 5 87525 17048 42516757
Myalgia 20.27 13.93 115 87415 95965 42437840
Substance use disorder 20.17 13.93 38 87492 5307 42528498
Benign prostatic hyperplasia 20.12 13.93 9 87521 21043 42512762
Inappropriate antidiuretic hormone secretion 19.99 13.93 77 87453 16464 42517341
Dysphemia 19.94 13.93 22 87508 1880 42531925
Vomiting 19.43 13.93 450 87080 289273 42244532
Hypertonia 19.43 13.93 36 87494 4965 42528840
Adverse event 19.40 13.93 98 87432 23542 42510263
Skin turgor decreased 19.37 13.93 13 87517 562 42533243
Pneumonia aspiration 19.33 13.93 172 87358 49906 42483899
Eczema 19.27 13.93 25 87505 34061 42499744
Anorgasmia 19.09 13.93 17 87513 1120 42532685
Nephrectasia 19.05 13.93 5 87525 15 42533790
Orthostatic hypertension 18.93 13.93 12 87518 470 42533335
Ornithine transcarbamoylase deficiency 18.81 13.93 5 87525 16 42533789
Obstructive airways disorder 18.80 13.93 14 87516 24745 42509060
Rash erythematous 18.70 13.93 23 87507 32068 42501737
Osteomyelitis 18.69 13.93 7 87523 18216 42515589
Bone pain 18.66 13.93 13 87517 23779 42510026
Gender dysphoria 18.63 13.93 6 87524 43 42533762
Sinus arrhythmia 18.60 13.93 15 87515 862 42532943
Lung neoplasm malignant 18.59 13.93 8 87522 19139 42514666
Pulmonary hypertension 18.32 13.93 13 87517 23556 42510249
Paraesthesia 18.29 13.93 83 87447 73376 42460429
Erection increased 18.29 13.93 12 87518 499 42533306
Clostridium difficile infection 18.28 13.93 12 87518 22647 42511158
Autonomic nervous system imbalance 18.27 13.93 27 87503 3089 42530716
Chest discomfort 18.27 13.93 68 87462 63548 42470257
Type 1 diabetes mellitus 18.26 13.93 37 87493 5450 42528355
Blood pressure fluctuation 18.23 13.93 17 87513 26891 42506914
Ejaculation delayed 18.21 13.93 10 87520 299 42533506
Pericardial effusion 18.12 13.93 20 87510 29255 42504550
Antidepressant drug level increased 17.92 13.93 9 87521 223 42533582
Grandiosity 17.88 13.93 10 87520 310 42533495
Rhesus incompatibility 17.84 13.93 6 87524 50 42533755
Screaming 17.83 13.93 21 87509 1926 42531879
Suicide threat 17.74 13.93 6 87524 51 42533754
Suspiciousness 17.65 13.93 11 87519 418 42533387
Negativism 17.61 13.93 11 87519 420 42533385
End stage renal disease 17.60 13.93 6 87524 16552 42517253
Blood urea increased 17.58 13.93 25 87505 32768 42501037
Proteinuria 17.44 13.93 13 87517 22970 42510835
Alcohol use disorder 17.44 13.93 6 87524 54 42533751
Oligospermia 17.39 13.93 7 87523 101 42533704
Panic attack 17.30 13.93 56 87474 10989 42522816
Weight decrease neonatal 17.29 13.93 10 87520 331 42533474
Acute myopia 17.21 13.93 5 87525 24 42533781
Diarrhoea infectious 17.20 13.93 13 87517 679 42533126
Cloacal exstrophy 17.15 13.93 6 87524 57 42533748
Cholecystitis 17.12 13.93 3 87527 12985 42520820
Squamous cell carcinoma 17.11 13.93 3 87527 12979 42520826
Atrial flutter 17.08 13.93 7 87523 17244 42516561
Haemorrhage intracranial 16.98 13.93 7 87523 17185 42516620
Meconium aspiration syndrome 16.97 13.93 6 87524 59 42533746
Aorta hypoplasia 16.96 13.93 7 87523 108 42533697
Flatulence 16.91 13.93 16 87514 25136 42508669
Underweight 16.85 13.93 13 87517 700 42533105
Bipolar I disorder 16.78 13.93 14 87516 844 42532961
Neuroleptic-induced deficit syndrome 16.73 13.93 5 87525 27 42533778
Cholelithiasis 16.72 13.93 14 87516 23332 42510473
Libido disorder 16.71 13.93 10 87520 353 42533452
Platelet count decreased 16.69 13.93 193 87337 138388 42395417
Delusional perception 16.68 13.93 8 87522 179 42533626
Coma scale abnormal 16.66 13.93 32 87498 4533 42529272
Skin disorder 16.58 13.93 7 87523 16937 42516868
Renal hypertension 16.58 13.93 9 87521 263 42533542
Hyperbilirubinaemia 16.55 13.93 11 87519 20624 42513181
Hepatic cirrhosis 16.49 13.93 10 87520 19692 42514113
Myopathy 16.44 13.93 4 87526 13757 42520048
Osteonecrosis 16.43 13.93 6 87524 15859 42517946
Tonic posturing 16.28 13.93 5 87525 30 42533775
Hyperammonaemia 16.25 13.93 44 87486 7822 42525983
Grimacing 16.24 13.93 10 87520 372 42533433
Blood ketone body 16.19 13.93 7 87523 122 42533683
Chest pain 16.16 13.93 196 87334 139334 42394471
Aplastic anaemia 16.02 13.93 3 87527 12381 42521424
Hypersomnia 16.02 13.93 66 87464 14552 42519253
Logorrhoea 16.00 13.93 24 87506 2783 42531022
Dermatillomania 15.98 13.93 6 87524 71 42533734
Atelectasis 15.96 13.93 10 87520 19351 42514454
Hip fracture 15.93 13.93 4 87526 13468 42520337
Hypoaesthesia 15.91 13.93 84 87446 71379 42462426
Osteoarthritis 15.86 13.93 16 87514 24389 42509416
Duodenal ulcer 15.83 13.93 3 87527 12276 42521529
Divorced 15.77 13.93 4 87526 10 42533795
Selective mutism 15.75 13.93 6 87524 74 42533731
Anterograde amnesia 15.75 13.93 9 87521 291 42533514
Heart rate increased 15.72 13.93 173 87357 53082 42480723
Foetal growth restriction 15.69 13.93 34 87496 5249 42528556
Gastric ulcer 15.66 13.93 9 87521 18253 42515552
Troponin increased 15.62 13.93 79 87451 18983 42514822
Hyperhidrosis 15.61 13.93 267 87263 90245 42443560
Hyperthyroidism 15.59 13.93 5 87525 14336 42519469
Complicated fracture 15.57 13.93 3 87527 0 42533805
Lymphoma 15.55 13.93 5 87525 14316 42519489
Food craving 15.52 13.93 11 87519 520 42533285
Glabellar reflex abnormal 15.50 13.93 5 87525 36 42533769
Product reconstitution quality issue 15.41 13.93 8 87522 213 42533592
Rabbit syndrome 15.39 13.93 5 87525 37 42533768
Rhinorrhoea 15.36 13.93 26 87504 31768 42502037
Bicuspid aortic valve 15.32 13.93 9 87521 307 42533498
Hypocalcaemia 15.21 13.93 24 87506 30149 42503656
Congestive cardiomyopathy 15.17 13.93 46 87484 8718 42525087
Acute respiratory failure 15.16 13.93 36 87494 38822 42494983
Floppy iris syndrome 15.11 13.93 9 87521 315 42533490
Hepatic failure 15.10 13.93 35 87495 38065 42495740
Sluggishness 15.08 13.93 28 87502 3868 42529937
High density lipoprotein decreased 15.07 13.93 28 87502 3869 42529936
Urosepsis 15.03 13.93 6 87524 15014 42518791
Excessive sexual fantasies 15 13.93 4 87526 13 42533792
Dysphagia 14.99 13.93 221 87309 72498 42461307
Ejaculation failure 14.97 13.93 13 87517 828 42532977
Parkinsonian rest tremor 14.93 13.93 9 87521 322 42533483
Binge eating 14.91 13.93 7 87523 149 42533656
Angina pectoris 14.91 13.93 28 87502 32868 42500937
Psychomotor skills impaired 14.90 13.93 33 87497 5171 42528634
Glycogen storage disorder 14.77 13.93 4 87526 14 42533791
Toxic epidermal necrolysis 14.73 13.93 20 87510 26730 42507075
Mucosal inflammation 14.69 13.93 52 87478 49322 42484483
Neoplasm malignant 14.68 13.93 15 87515 22728 42511077
Food interaction 14.67 13.93 14 87516 1008 42532797
Regurgitation 14.67 13.93 19 87511 1921 42531884
Cardiomyopathy 14.63 13.93 78 87452 19132 42514673
Electrocardiogram abnormal 14.61 13.93 50 87480 10095 42523710
Prader-Willi syndrome 14.56 13.93 4 87526 15 42533790
Blood insulin abnormal 14.56 13.93 4 87526 15 42533790
Flight of ideas 14.51 13.93 9 87521 339 42533466
Vasculitis 14.49 13.93 10 87520 18384 42515421
Intrusive thoughts 14.42 13.93 10 87520 456 42533349
Jaundice neonatal 14.42 13.93 20 87510 2159 42531646
Hypoalbuminaemia 14.41 13.93 7 87523 15603 42518202
Therapy partial responder 14.38 13.93 80 87450 19941 42513864
Delusion of reference 14.34 13.93 6 87524 96 42533709
Haematemesis 14.31 13.93 25 87505 30174 42503631
Nodule 14.30 13.93 4 87526 12530 42521275
Hypospadias 14.26 13.93 26 87504 3541 42530264
Wolff-Parkinson-White syndrome 14.25 13.93 8 87522 250 42533555
Malnutrition 14.24 13.93 6 87524 14536 42519269
Atrioventricular block complete 14.19 13.93 3 87527 11361 42522444
Impaired self-care 14.18 13.93 15 87515 1222 42532583
CADASIL 14.17 13.93 6 87524 99 42533706
Benign ethnic neutropenia 14.17 13.93 6 87524 99 42533706
Inappropriate affect 14.09 13.93 12 87518 744 42533061
Major depression 14.09 13.93 33 87497 5365 42528440
Disorganised speech 14.08 13.93 16 87514 1412 42532393
Ataxia 14.05 13.93 68 87462 16057 42517748
Contusion 14.03 13.93 42 87488 41943 42491862
Troponin I increased 13.96 13.93 24 87506 3122 42530683

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Akathisia 3239.01 12.53 1151 167224 15962 110404962
Extrapyramidal disorder 2619.04 12.53 1140 167235 27727 110393197
Dystonia 2291.83 12.53 1004 167371 24801 110396123
Tardive dyskinesia 2194.75 12.53 813 167562 12766 110408158
Neuroleptic malignant syndrome 2193.49 12.53 1060 167315 32999 110387925
Sedation 1903.74 12.53 1234 167141 68449 110352475
Suicide attempt 1784.28 12.53 1383 166992 102011 110318913
Psychotic disorder 1761.01 12.53 1048 167327 49889 110371035
Dyskinesia 1609.87 12.53 993 167382 50453 110370471
Hallucination, auditory 1551.32 12.53 772 167603 25625 110395299
Parkinsonism 1527.13 12.53 723 167652 21464 110399460
Suicidal ideation 1405.80 12.53 1156 167219 92781 110328143
Delusion 1399.66 12.53 696 167679 23059 110397865
Sexual dysfunction 1360.97 12.53 506 167869 8024 110412900
Blood prolactin abnormal 1187.98 12.53 374 168001 3461 110417463
Product use in unapproved indication 1169.49 12.53 2285 166090 445092 109975832
Treatment noncompliance 1167.43 12.53 934 167441 72056 110348868
Hyperprolactinaemia 1001.39 12.53 377 167998 6198 110414726
Weight increased 894.73 12.53 1972 166403 417672 110003252
Mania 890.02 12.53 492 167883 20304 110400620
Anosognosia 885.64 12.53 304 168071 3770 110417154
Aggression 867.34 12.53 720 167655 58490 110362434
Drug interaction 852.94 12.53 2154 166221 498029 109922895
Agitation 807.65 12.53 927 167448 112124 110308800
Gambling disorder 785.45 12.53 239 168136 1952 110418972
Disturbance in social behaviour 784.76 12.53 294 168081 4764 110416160
Tremor 779.80 12.53 1227 167148 201005 110219919
Oculogyric crisis 767.57 12.53 269 168106 3563 110417361
Psychotic symptom 746.10 12.53 264 168111 3603 110417321
Salivary hypersecretion 734.11 12.53 408 167967 17013 110403911
Intentional self-injury 691.78 12.53 522 167853 36907 110384017
Metabolic disorder 691.07 12.53 332 168043 10178 110410746
Restlessness 687.78 12.53 617 167758 55642 110365282
Abnormal behaviour 635.54 12.53 505 167870 38534 110382390
Irritability 611.58 12.53 538 167837 47271 110373653
Somnolence 600.80 12.53 1369 167006 296080 110124844
Intentional overdose 600.21 12.53 867 167508 131634 110289290
Schizophrenia 579.53 12.53 380 167995 21446 110399478
Personality change 576.82 12.53 298 168077 10704 110410220
Muscle rigidity 548.66 12.53 381 167994 23650 110397274
Blood creatine phosphokinase increased 497.87 12.53 585 167790 72492 110348432
Anxiety 451.44 12.53 1350 167025 343728 110077196
Drug abuse 446.07 12.53 893 167482 176518 110244406
Electrocardiogram QT prolonged 444.57 12.53 679 167696 108281 110312643
Catatonia 439.12 12.53 251 168124 11049 110409875
Joint swelling 420.52 12.53 82 168293 442763 109978161
Hypersexuality 407.07 12.53 141 168234 1799 110419125
Psychomotor hyperactivity 406.45 12.53 297 168078 19980 110400944
Serotonin syndrome 400.36 12.53 472 167903 58681 110362243
Infusion related reaction 394.21 12.53 56 168319 381106 110039818
Thinking abnormal 393.19 12.53 260 168115 14880 110406044
Arthralgia 388.87 12.53 369 168006 779263 109641661
Dyspnoea 374.91 12.53 698 167677 1106174 109314750
Mental impairment 370.87 12.53 294 168081 22345 110398579
Apathy 367.26 12.53 256 168119 15983 110404941
Diarrhoea 358.00 12.53 751 167624 1138754 109282170
Stubbornness 351.53 12.53 90 168285 351 110420573
Psychiatric decompensation 345.64 12.53 171 168204 5594 110415330
Pain 341.36 12.53 582 167793 954373 109466551
Galactorrhoea 340.81 12.53 153 168222 4002 110416922
Paranoia 335.67 12.53 276 168099 22098 110398826
Persecutory delusion 334.39 12.53 172 168203 6119 110414805
Arthropathy 330.54 12.53 29 168346 287493 110133431
Overdose 329.78 12.53 940 167435 232854 110188070
Social avoidant behaviour 312.26 12.53 156 168219 5213 110415711
Psychiatric symptom 311.47 12.53 187 168188 9026 110411898
Febrile neutropenia 306.25 12.53 56 168319 316711 110104213
Systemic lupus erythematosus 305.43 12.53 21 168354 254317 110166607
Blood prolactin increased 303.23 12.53 146 168229 4496 110416428
Completed suicide 299.57 12.53 930 167445 241451 110179473
Swelling 299.37 12.53 82 168293 350959 110069965
Synovitis 298.50 12.53 34 168341 274058 110146866
Pneumonia 291.06 12.53 559 167816 876155 109544769
Schizoaffective disorder 281.43 12.53 123 168252 3013 110417911
Glossodynia 279.74 12.53 14 168361 221990 110198934
Drug ineffective 271.86 12.53 3514 164861 1517026 108903898
Depressed mood 268.01 12.53 393 167982 60416 110360508
Anaemia 267.73 12.53 263 168112 546823 109874101
Metabolic syndrome 264.52 12.53 119 168256 3128 110417796
Hallucination 263.72 12.53 518 167857 100914 110320010
Abdominal discomfort 261.03 12.53 137 168238 393721 110027203
Obsessive-compulsive disorder 260.52 12.53 153 168222 7088 110413836
Emotional poverty 259.15 12.53 86 168289 954 110419970
Stomatitis 258.58 12.53 49 168326 270193 110150731
Blood glucose increased 250.76 12.53 595 167780 131901 110289023
Affective disorder 244.40 12.53 173 168202 11068 110409856
Increased appetite 244.24 12.53 194 168181 14783 110406141
Rash 241.73 12.53 560 167815 820404 109600520
Orthostatic hypertension 235.77 12.53 80 168295 955 110419969
Drooling 233.84 12.53 142 168233 6997 110413927
Rhabdomyolysis 231.44 12.53 544 167831 119857 110301067
Rheumatoid arthritis 230.45 12.53 84 168291 299529 110121395
Contraindicated product administered 229.21 12.53 49 168326 248218 110172706
Mental disorder 229.11 12.53 289 168086 38502 110382422
Tic 228.58 12.53 110 168265 3383 110417541
Folliculitis 226.94 12.53 6 168369 167647 110253277
Sinusitis 226.81 12.53 84 168291 296604 110124320
Underdose 224.59 12.53 371 168004 63183 110357741
Disinhibition 221.30 12.53 104 168271 3030 110417894
Antipsychotic drug level increased 220.74 12.53 136 168239 6879 110414045
Hypersensitivity 218.19 12.53 177 168198 403821 110017103
Compulsive shopping 217.18 12.53 72 168303 796 110420128
Cogwheel rigidity 216.69 12.53 108 168267 3590 110417334
Impulse-control disorder 216.41 12.53 92 168283 2102 110418822
Drug hypersensitivity 215.56 12.53 224 168151 453866 109967058
Pruritus 210.51 12.53 351 168024 581209 109839715
Myocarditis 206.93 12.53 242 168133 29813 110391111
Antipsychotic drug level below therapeutic 205.80 12.53 83 168292 1652 110419272
Sopor 202.82 12.53 264 168111 36282 110384642
General physical health deterioration 201.62 12.53 210 168165 425085 109995839
Mood altered 199.42 12.53 202 168173 21173 110399751
Impaired healing 198.41 12.53 31 168344 196686 110224238
Wheezing 197.20 12.53 71 168304 255159 110165765
Malignant neoplasm progression 196.84 12.53 19 168356 174548 110246376
Hypomania 194.38 12.53 145 168230 10065 110410859
Drug intolerance 193.51 12.53 200 168175 406312 110014612
Muscle injury 190.72 12.53 5 168370 140802 110280122
Osteoarthritis 190.63 12.53 26 168349 182597 110238327
Priapism 190.49 12.53 116 168259 5745 110415179
Nasopharyngitis 187.74 12.53 194 168181 394167 110026757
Euphoric mood 187.64 12.53 134 168241 8693 110412231
Sinus tachycardia 183.80 12.53 279 168096 44214 110376710
Homicidal ideation 183.68 12.53 96 168279 3531 110417393
Gestational diabetes 182.48 12.53 123 168252 7266 110413658
Toxicity to various agents 179.87 12.53 1300 167075 479255 109941669
Seizure 179.83 12.53 740 167635 220445 110200479
Posture abnormal 178.94 12.53 101 168274 4337 110416587
Blister 177.80 12.53 62 168313 227314 110193610
Musculoskeletal pain 177.58 12.53 32 168343 182991 110237933
Irritable bowel syndrome 177.16 12.53 21 168354 164194 110256730
Torticollis 176.80 12.53 90 168285 3131 110417793
Peripheral swelling 173.56 12.53 216 168159 403818 110017106
Infection 172.59 12.53 178 168197 362022 110058902
Diabetes mellitus 171.70 12.53 431 167944 98950 110321974
Hepatic enzyme increased 171.46 12.53 142 168233 320750 110100174
Hostility 170.68 12.53 83 168292 2613 110418311
Urticaria 170.50 12.53 141 168234 318716 110102208
Wound 169.91 12.53 72 168303 234365 110186559
Pain in extremity 167.99 12.53 303 168072 486815 109934109
Lower respiratory tract infection 167.84 12.53 80 168295 243026 110177898
Cough 166.61 12.53 279 168096 461362 109959562
Mobility decreased 165.65 12.53 77 168298 237345 110183579
Hypothermia 163.39 12.53 201 168174 26101 110394823
Hallucination, visual 163.10 12.53 248 168127 39357 110381567
Pericarditis 162.51 12.53 65 168310 219049 110201875
Hallucinations, mixed 162.25 12.53 122 168253 8571 110412353
Coma 160.30 12.53 468 167907 117401 110303523
Bruxism 160.15 12.53 98 168277 4896 110416028
Psychomotor retardation 155.85 12.53 114 168261 7678 110413246
Ill-defined disorder 153.09 12.53 27 168348 156826 110264098
Joint range of motion decreased 152.44 12.53 8 168367 121824 110299100
Depression 150.47 12.53 911 167464 316424 110104500
Drug monitoring procedure incorrectly performed 149.31 12.53 53 168322 730 110420194
Libido increased 148.32 12.53 74 168301 2465 110418459
Bursitis 146.83 12.53 14 168361 129904 110291020
Sleep disorder due to general medical condition, insomnia type 145.97 12.53 3 168372 105640 110315284
Fibromyalgia 145.45 12.53 40 168335 170869 110250055
Alopecia 145.42 12.53 206 168169 364547 110056377
Delusion of grandeur 144.35 12.53 70 168305 2190 110418734
Muscle twitching 142.91 12.53 201 168174 29734 110391190
Psoriatic arthropathy 141.66 12.53 61 168314 196700 110224224
Pyrexia 141.24 12.53 797 167578 897468 109523456
Arthritis 141.17 12.53 40 168335 167546 110253378
Refusal of treatment by patient 140.06 12.53 116 168259 9378 110411546
Gambling 139.43 12.53 42 168333 330 110420594
Insurance issue 138.82 12.53 121 168254 10491 110410433
Product administered to patient of inappropriate age 137.29 12.53 107 168268 7929 110412995
Disturbance in attention 135.68 12.53 295 168080 61700 110359224
Impulsive behaviour 135.17 12.53 76 168299 3239 110417685
Abdominal pain 134.36 12.53 371 168004 512618 109908306
Bradyphrenia 134.19 12.53 124 168251 11604 110409320
Hyperphagia 133.35 12.53 77 168298 3454 110417470
Compulsive sexual behaviour 131.35 12.53 38 168337 255 110420669
Gastrointestinal disorder 130.54 12.53 106 168269 241846 110179078
Poisoning deliberate 130.48 12.53 180 168195 26151 110394773
Tachycardia 129.41 12.53 684 167691 225961 110194963
Therapeutic product effect decreased 129.39 12.53 109 168266 244207 110176717
Disease progression 129.08 12.53 109 168266 243925 110176999
Dysarthria 129.08 12.53 349 168026 83772 110337152
Sedation complication 128.64 12.53 155 168220 19700 110401224
Prescribed underdose 127.95 12.53 297 168078 64877 110356047
Insomnia 123.74 12.53 956 167419 359634 110061290
Lung disorder 121.60 12.53 61 168314 179986 110240938
Cognitive disorder 121.41 12.53 350 168025 87161 110333763
Asthenia 120.69 12.53 589 167786 688410 109732514
Neutrophil count increased 120.68 12.53 201 168174 34451 110386473
Substance abuse 120.33 12.53 120 168255 12343 110408581
Acute kidney injury 120.29 12.53 528 167847 634902 109786022
Abdominal pain upper 119.53 12.53 218 168157 348893 110072031
Fatigue 118.73 12.53 1232 167143 1214726 109206198
Bipolar disorder 118.42 12.53 103 168272 8904 110412020
Inflammation 118.22 12.53 74 168301 193164 110227760
Urinary retention 118.04 12.53 300 168075 69383 110351541
Altered state of consciousness 117.98 12.53 267 168108 57359 110363565
Urinary incontinence 117.70 12.53 241 168134 48346 110372578
Anger 117.65 12.53 145 168230 18862 110402062
Gaze palsy 117.36 12.53 70 168305 3337 110417587
Blood triglycerides increased 116.22 12.53 162 168213 23764 110397160
Sepsis 116.04 12.53 200 168175 327146 110093778
Acute psychosis 115.99 12.53 80 168295 4907 110416017
Antipsychotic drug level decreased 115.82 12.53 52 168323 1360 110419564
Bradykinesia 115.64 12.53 110 168265 10678 110410246
Logorrhoea 114.08 12.53 79 168296 4878 110416046
Suppressed lactation 113.62 12.53 35 168340 299 110420625
Pulmonary fibrosis 112.69 12.53 12 168363 102030 110318894
Myelosuppression 112.59 12.53 8 168367 94332 110326592
Discomfort 112.21 12.53 97 168278 214610 110206314
Gynaecomastia 111.82 12.53 102 168273 9388 110411536
Back pain 111.37 12.53 250 168125 370746 110050178
Paraesthesia 109.35 12.53 157 168218 276364 110144560
Night sweats 109.16 12.53 34 168341 133949 110286975
Infarction 107.45 12.53 78 168297 5191 110415733
Acute myopia 106.57 12.53 30 168345 180 110420744
Amenorrhoea 106.39 12.53 98 168277 9133 110411791
Depressive symptom 106.18 12.53 94 168281 8320 110412604
Eosinophil count decreased 104.70 12.53 81 168294 5937 110414987
Self-injurious ideation 104.12 12.53 71 168304 4275 110416649
Erythema 103.35 12.53 178 168197 291269 110129655
Speech disorder 103.18 12.53 264 168111 61305 110359619
Caesarean section 103.11 12.53 116 168259 13701 110407223
Withdrawal syndrome 102.63 12.53 177 168198 31203 110389721
Trismus 102.36 12.53 83 168292 6513 110414411
Depressed level of consciousness 101.94 12.53 389 167986 111889 110309035
Rabbit syndrome 100.27 12.53 33 168342 356 110420568
Mydriasis 100.21 12.53 145 168230 22012 110398912
Libido decreased 99.18 12.53 78 168297 5857 110415067
Intentional product use issue 98.76 12.53 140 168235 247766 110173158
Oppositional defiant disorder 98.54 12.53 35 168340 483 110420441
Dystonic tremor 97.25 12.53 32 168343 345 110420579
Oedema 96.81 12.53 106 168269 209870 110211054
Dyslipidaemia 95.94 12.53 120 168255 15845 110405079
Pleural effusion 93.20 12.53 80 168295 177629 110243295
Liver injury 92.83 12.53 57 168318 150356 110270568
Ascites 92.71 12.53 15 168360 92793 110328131
Peripheral venous disease 92.61 12.53 10 168365 84107 110336817
Grip strength decreased 92.31 12.53 8 168367 80166 110340758
Vertigo 91.59 12.53 316 168059 86554 110334370
Wrong technique in product usage process 91.45 12.53 317 168058 87031 110333893
Nausea 91.36 12.53 1329 167046 1234361 109186563
Atrial fibrillation 91.16 12.53 130 168245 229512 110191412
Colitis 90.78 12.53 22 168353 102301 110318623
Off label use 90.15 12.53 2950 165425 1497235 108923689
Cytokine release syndrome 89.93 12.53 4 168371 70302 110350622
Gastrointestinal haemorrhage 89.90 12.53 72 168303 165446 110255478
Rectal haemorrhage 89.72 12.53 35 168340 119798 110301126
Wound infection 89.06 12.53 19 168356 96446 110324478
Autism spectrum disorder 88.61 12.53 48 168327 1900 110419024
Headache 88.41 12.53 888 167487 881489 109539435
Symptom recurrence 86.91 12.53 66 168309 4706 110416218
Hypertonia 86.86 12.53 84 168291 8322 110412602
Paradoxical drug reaction 86.54 12.53 90 168285 9727 110411197
Stupor 86.17 12.53 83 168292 8182 110412742
Choreoathetosis 86.15 12.53 45 168330 1653 110419271
Mood swings 85.77 12.53 137 168238 22675 110398249
Blunted affect 85.65 12.53 32 168343 514 110420410
Flat affect 85.07 12.53 51 168324 2454 110418470
Contusion 84.12 12.53 141 168234 233220 110187704
Antipsychotic drug level above therapeutic 83.70 12.53 50 168325 2390 110418534
Decreased appetite 83.67 12.53 406 167969 475440 109945484
Upper respiratory tract infection 83.53 12.53 48 168327 131280 110289644
Tension 83.27 12.53 66 168309 5012 110415912
Affect lability 82.88 12.53 121 168254 18516 110402408
Behaviour disorder 82.47 12.53 87 168288 9560 110411364
Injury 82.25 12.53 89 168286 177176 110243748
Victim of child abuse 81.87 12.53 39 168336 1172 110419752
Economic problem 81.63 12.53 60 168315 4071 110416853
Pleurothotonus 80.05 12.53 49 168326 2449 110418475
Intentional product misuse 79.89 12.53 407 167968 132497 110288427
Mutism 79.71 12.53 53 168322 3060 110417864
Hypokinesia 79.23 12.53 129 168246 21697 110399227
Drug dependence 79.22 12.53 210 168165 49810 110371114
Abortion induced 78.88 12.53 78 168297 7941 110412983
Oromandibular dystonia 78.59 12.53 38 168337 1181 110419743
Abortion spontaneous 78.30 12.53 166 168209 34116 110386808
Poor personal hygiene 78.24 12.53 31 168344 588 110420336
Refusal of examination 76.03 12.53 24 168351 224 110420700
Pregnancy on contraceptive 75.98 12.53 35 168340 973 110419951
Stereotypy 75.69 12.53 35 168340 982 110419942
Cardiac failure congestive 75.55 12.53 71 168304 150929 110269995
Enuresis 75.37 12.53 57 168318 4039 110416885
Hyperhidrosis 75.33 12.53 516 167859 186782 110234142
Substance-induced psychotic disorder 75.32 12.53 64 168311 5360 110415564
Epidural lipomatosis 75.21 12.53 44 168331 2023 110418901
Self-destructive behaviour 74.99 12.53 33 168342 822 110420102
Blood prolactin decreased 74.88 12.53 25 168350 283 110420641
Hyperreflexia 74.86 12.53 82 168293 9403 110411521
Water intoxication 74.49 12.53 34 168341 925 110419999
Bipolar I disorder 73.72 12.53 45 168330 2238 110418686
Septic shock 73.19 12.53 79 168296 157449 110263475
Haematochezia 72.37 12.53 43 168332 115481 110305443
Hypoaesthesia 72.33 12.53 241 168134 313982 110106942
Oedema peripheral 72.33 12.53 257 168118 328403 110092521
Soliloquy 72.27 12.53 34 168341 993 110419931
Inappropriate schedule of product administration 72.06 12.53 544 167831 203093 110217831
Restless legs syndrome 71.66 12.53 132 168243 24494 110396430
Dysphagia 71.46 12.53 439 167936 153161 110267763
Therapeutic product effect variable 71.35 12.53 47 168328 2671 110418253
Social problem 71.13 12.53 41 168334 1833 110419091
Pneumonia aspiration 70.91 12.53 278 168097 80955 110339969
Hypoprolactinaemia 70.54 12.53 15 168360 18 110420906
Plasma cell myeloma 70.53 12.53 7 168368 62929 110357995
Pseudomyopia 70.51 12.53 21 168354 158 110420766
Spasmodic dysphonia 69.90 12.53 28 168347 547 110420377
Liver disorder 69.86 12.53 68 168307 142175 110278749
Suicidal behaviour 69.57 12.53 51 168324 3446 110417478
Renal failure 69.33 12.53 151 168224 226423 110194501
Granulocytopenia 69.22 12.53 91 168284 12624 110408300
Sexually inappropriate behaviour 69.06 12.53 29 168346 642 110420282
Electrocardiogram QRS complex prolonged 69.05 12.53 92 168283 12929 110407995
Nail disorder 68.88 12.53 5 168370 57930 110362994
Sudden death 68.78 12.53 129 168246 24266 110396658
Myoclonus 68.77 12.53 154 168221 32844 110388080
Lymphocyte count abnormal 68.71 12.53 44 168331 2382 110418542
Multiple organ dysfunction syndrome 68.37 12.53 78 168297 151632 110269292
Malignant catatonia 67.63 12.53 29 168346 677 110420247
Substance use 67.41 12.53 44 168331 2462 110418462
Obsessive thoughts 67.35 12.53 35 168340 1272 110419652
Hiccups 66.82 12.53 90 168285 12779 110408145
Inappropriate affect 66.70 12.53 38 168337 1661 110419263
Thrombocytopenia 64.64 12.53 292 168083 348593 110072331
Melaena 64.59 12.53 13 168362 68744 110352180
Paroxysmal perceptual alteration 64.43 12.53 22 168353 268 110420656
Sciatica 64.36 12.53 30 168345 92369 110328555
Skin ulcer 64.21 12.53 10 168365 63635 110357289
Haemoptysis 63.97 12.53 15 168360 71339 110349585
Inappropriate antidiuretic hormone secretion 63.96 12.53 152 168223 33699 110387225
Cytomegalovirus infection 63.87 12.53 5 168370 54439 110366485
Gait inability 63.79 12.53 68 168307 136308 110284616
Interstitial lung disease 63.49 12.53 71 168304 139263 110281661
Pancytopenia 63.06 12.53 141 168234 209472 110211452
Respiratory depression 62.98 12.53 146 168229 31855 110389069
Movement disorder 62.97 12.53 158 168217 36246 110384678
Herpes zoster 62.89 12.53 44 168331 108335 110312589
Psychomotor skills impaired 62.75 12.53 65 168310 6993 110413931
Trimethylaminuria 62.58 12.53 20 168355 195 110420729
Autoimmune disorder 62.32 12.53 12 168363 65471 110355453
Megacolon 62.26 12.53 52 168323 4253 110416671
Social anxiety disorder 61.94 12.53 30 168345 936 110419988
Crying 61.92 12.53 127 168248 25501 110395423
Eye movement disorder 61.48 12.53 75 168300 9653 110411271
Child abuse 61.23 12.53 29 168346 860 110420064
Loss of libido 60.77 12.53 45 168330 3088 110417836
Decreased eye contact 60.43 12.53 29 168346 886 110420038
Asthma 60.35 12.53 188 168187 250103 110170821
Frequent bowel movements 60.18 12.53 17 168358 71373 110349551
Physical assault 60.15 12.53 35 168340 1593 110419331
Accidental exposure to product by child 59.94 12.53 45 168330 3153 110417771
Psychosexual disorder 58.93 12.53 18 168357 149 110420775
Personality change due to a general medical condition 58.85 12.53 21 168354 294 110420630
Abulia 58.74 12.53 32 168343 1281 110419643
Vomiting 58.22 12.53 1006 167369 909669 109511255
Delusional disorder, unspecified type 58.12 12.53 28 168347 863 110420061
Negative symptoms in schizophrenia 58.06 12.53 19 168356 201 110420723
Personality disorder 58.04 12.53 84 168291 12753 110408171
Apraxia 58.03 12.53 46 168329 3494 110417430
Pneumonitis 57.87 12.53 22 168353 76509 110344415
Head titubation 57.75 12.53 32 168343 1325 110419599
Malaise 57.68 12.53 700 167675 671119 109749805
Abdominal distension 57.54 12.53 112 168263 174991 110245933
Binge eating 57.47 12.53 25 168350 605 110420319
Substance dependence 57.25 12.53 26 168349 699 110420225
Erectile dysfunction 57.22 12.53 102 168273 18454 110402470
Coronary artery disease 56.96 12.53 19 168356 71671 110349253
Drug level increased 56.91 12.53 181 168194 47538 110373386
Dyspnoea exertional 56.83 12.53 45 168330 104015 110316909
Death 56.71 12.53 737 167638 698132 109722792
Hospitalisation 56.36 12.53 391 167984 142102 110278822
Maternal exposure during pregnancy 55.93 12.53 614 167761 254269 110166655
Hyperthermia 55.69 12.53 109 168266 21163 110399761
Neurodegenerative disorder 55.21 12.53 26 168349 761 110420163
Activation syndrome 55.01 12.53 21 168354 359 110420565
Reduced facial expression 54.67 12.53 45 168330 3606 110417318
Taste disorder 54.32 12.53 16 168359 65371 110355553
Tongue biting 54.30 12.53 41 168334 2898 110418026
Product substitution issue 54.21 12.53 113 168262 22948 110397976
Hypersomnia 54.10 12.53 127 168248 27934 110392990
Delusional disorder, persecutory type 54.09 12.53 24 168351 610 110420314
Sudden cardiac death 53.91 12.53 54 168321 5583 110415341
Knee arthroplasty 53.76 12.53 16 168359 64932 110355992
Loss of consciousness 53.73 12.53 495 167880 195811 110225113
Hypoxia 53.71 12.53 71 168304 129444 110291480
Delirium 53.69 12.53 371 168004 134654 110286270
Disturbance in sexual arousal 53.66 12.53 21 168354 385 110420539
Feeling guilty 53.58 12.53 27 168348 919 110420005
Ataxia 53.47 12.53 132 168243 29976 110390948
Keratoconus 53.45 12.53 17 168358 163 110420761
Therapy cessation 53.36 12.53 170 168205 44687 110376237
Miosis 53.18 12.53 109 168266 21874 110399050
Prescribed overdose 53.18 12.53 269 168106 87312 110333612
Disorientation 53.13 12.53 231 168144 70440 110350484
Antidepressant drug level above therapeutic 53.08 12.53 25 168350 732 110420192
Compulsions 52.97 12.53 21 168354 399 110420525
Diabetic ketoacidosis 52.43 12.53 162 168213 41896 110379028
Productive cough 52.34 12.53 58 168317 114247 110306677
Bone marrow failure 52.17 12.53 12 168363 57836 110363088
Cerebral haemorrhage 52.00 12.53 17 168358 64951 110355973
Reversible cerebral vasoconstriction syndrome 51.89 12.53 49 168326 4712 110416212
Abortion 51.87 12.53 32 168343 1622 110419302
Rhinalgia 51.79 12.53 45 168330 3884 110417040
Nephrogenic diabetes insipidus 51.70 12.53 37 168338 2408 110418516
Obesity 51.48 12.53 322 168053 113029 110307895
Fluid retention 51.23 12.53 41 168334 94266 110326658
Osteoporosis 51.08 12.53 35 168340 87117 110333807
Tachyphrenia 50.61 12.53 36 168339 2320 110418604
Obsessive-compulsive symptom 50.58 12.53 19 168356 310 110420614
Haematuria 50.45 12.53 32 168343 82973 110337951
Parkinsonian rest tremor 50.44 12.53 20 168355 380 110420544
Parkinsonian gait 50.39 12.53 27 168348 1045 110419879
Anxiolytic therapy 50.32 12.53 13 168362 53 110420871
Drug therapy enhancement 50.32 12.53 13 168362 53 110420871
Post-traumatic stress disorder 50.29 12.53 56 168319 6540 110414384
Gastrooesophageal reflux disease 50.19 12.53 126 168249 179850 110241074
Leukopenia 50.12 12.53 393 167982 148398 110272526
Hepatotoxicity 50.02 12.53 17 168358 63383 110357541
Hip arthroplasty 49.50 12.53 12 168363 55801 110365123
Muscle contracture 49.30 12.53 38 168337 2770 110418154
Victim of crime 49.17 12.53 29 168346 1354 110419570
Hallucination, olfactory 49.12 12.53 22 168353 572 110420352
Analgesic drug level above therapeutic 49.07 12.53 21 168354 488 110420436
Substance use disorder 49.01 12.53 58 168317 7232 110413692
Muscle contractions involuntary 48.94 12.53 46 168329 4398 110416526
Lactation disorder 48.83 12.53 18 168357 278 110420646
Cardiac failure 48.80 12.53 136 168239 187490 110233434
Major depression 48.75 12.53 70 168305 10551 110410373
Schizophreniform disorder 48.75 12.53 16 168359 171 110420753
Lower limb fracture 48.68 12.53 27 168348 75321 110345603
Chest pain 48.68 12.53 354 168021 376021 110044903
Electrocardiogram QT shortened 48.47 12.53 18 168357 284 110420640
Generalised tonic-clonic seizure 48.42 12.53 188 168187 54492 110366432
Treatment failure 48.41 12.53 237 168138 276997 110143927
Dissociation 48.34 12.53 67 168308 9775 110411149
Staring 48.31 12.53 38 168337 2854 110418070
Dysphoria 48.02 12.53 54 168321 6374 110414550
Drug effective for unapproved indication 47.76 12.53 81 168294 14086 110406838
Osteonecrosis of jaw 47.42 12.53 8 168367 48009 110372915
Autonomic nervous system imbalance 47.42 12.53 51 168324 5729 110415195
Hyperkalaemia 47.14 12.53 84 168291 135712 110285212
Accommodation disorder 47.13 12.53 22 168353 631 110420293
Hepatic cirrhosis 47.03 12.53 22 168353 67604 110353320
Drug withdrawal syndrome 46.90 12.53 146 168229 37908 110383016
Exostosis 46.87 12.53 7 168368 45949 110374975
Alice in wonderland syndrome 46.63 12.53 12 168363 48 110420876
Anhedonia 46.54 12.53 84 168291 15344 110405580
Polydipsia 46.54 12.53 58 168317 7630 110413294
Red blood cell sedimentation rate increased 46.48 12.53 31 168344 78271 110342653
Somnambulism 46.48 12.53 53 168322 6352 110414572
Food craving 46.28 12.53 32 168343 1971 110418953
Acute myeloid leukaemia 46.15 12.53 3 168372 38107 110382817
Foot deformity 45.89 12.53 9 168366 48471 110372453
Cardio-respiratory arrest 45.89 12.53 318 168057 115518 110305406
Bankruptcy 45.69 12.53 11 168364 31 110420893
Hypercalcaemia 45.58 12.53 8 168367 46649 110374275
Tongue movement disturbance 44.91 12.53 20 168355 513 110420411
Neuropathy peripheral 44.39 12.53 133 168242 179144 110241780
Akinesia 44.35 12.53 40 168335 3627 110417297
Colitis ulcerative 44.11 12.53 32 168343 77331 110343593
Somatic hallucination 43.97 12.53 12 168363 63 110420861
Hypercholesterolaemia 43.94 12.53 44 168331 90793 110330131
Onychomycosis 43.93 12.53 4 168371 38527 110382397
Delusion of reference 43.89 12.53 16 168359 239 110420685
Male sexual dysfunction 43.83 12.53 17 168358 304 110420620
Product availability issue 43.77 12.53 57 168318 7833 110413091
Basal cell carcinoma 43.71 12.53 8 168367 45262 110375662
Muscular weakness 43.61 12.53 212 168163 248256 110172668
Epistaxis 43.17 12.53 83 168292 130289 110290635
International normalised ratio increased 43.16 12.53 41 168334 86731 110334193
Vision blurred 43.02 12.53 340 168035 128682 110292242
Diverticulitis 42.84 12.53 14 168361 53508 110367416
Eosinophilic myocarditis 42.82 12.53 31 168344 2054 110418870
Homosexuality 42.74 12.53 11 168364 44 110420880
Liver function test increased 42.71 12.53 43 168332 88505 110332419
Prostate cancer 42.67 12.53 4 168371 37637 110383287
Sleep-related eating disorder 42.65 12.53 23 168352 902 110420022
Soft tissue injury 42.60 12.53 32 168343 2244 110418680
Palmar-plantar erythrodysaesthesia syndrome 42.41 12.53 6 168369 41019 110379905
Floppy iris syndrome 42.21 12.53 17 168358 337 110420587
Negative thoughts 42.09 12.53 28 168347 1618 110419306
Adjustment disorder with depressed mood 41.84 12.53 8 168367 43875 110377049
Immunodeficiency 41.79 12.53 5 168370 38833 110382091
Blood pressure systolic increased 41.53 12.53 39 168336 82952 110337972
Emotional distress 41.20 12.53 156 168219 44691 110376233
Bronchiectasis 41.05 12.53 4 168371 36489 110384435
Hyperkinesia 41.03 12.53 36 168339 3148 110417776
Post-traumatic neck syndrome 41.00 12.53 33 168342 2562 110418362
Homeless 40.93 12.53 13 168362 124 110420800
Troponin T increased 40.72 12.53 41 168334 4265 110416659
Type 1 diabetes mellitus 40.61 12.53 59 168316 8988 110411936
Threatened labour 40.60 12.53 20 168355 648 110420276
Chills 40.59 12.53 151 168224 190429 110230495
Poor quality sleep 40.58 12.53 114 168261 27963 110392961
Heat stroke 40.27 12.53 29 168346 1906 110419018
Ideas of reference 40.18 12.53 14 168361 182 110420742
Injection site reaction 39.90 12.53 46 168329 89024 110331900
Disorganised speech 39.89 12.53 36 168339 3267 110417657
Lupus-like syndrome 39.84 12.53 7 168368 40785 110380139
Negativism 39.79 12.53 22 168353 907 110420017
Oropharyngeal spasm 39.70 12.53 18 168357 482 110420442
Weight decreased 39.62 12.53 489 167886 467568 109953356
Slow response to stimuli 39.56 12.53 29 168346 1959 110418965
Product prescribing error 39.52 12.53 169 168206 51162 110369762
Metastases to liver 39.48 12.53 4 168371 35382 110385542
Rash pruritic 39.41 12.53 55 168320 98014 110322910
Oscillopsia 38.95 12.53 17 168358 415 110420509
Haemoglobin decreased 38.75 12.53 221 168154 248506 110172418
Resting tremor 38.57 12.53 27 168348 1696 110419228
Neck pain 38.53 12.53 81 168294 123049 110297875
Hallucination, tactile 37.97 12.53 22 168353 993 110419931
Anterograde amnesia 37.96 12.53 21 168354 867 110420057
Paraphilia 37.87 12.53 11 168364 75 110420849
Incorrect dose administered 37.84 12.53 279 168096 103362 110317562
Bronchitis 37.81 12.53 118 168257 156914 110264010
Grandiosity 37.18 12.53 18 168357 561 110420363
Coeliac disease 36.93 12.53 10 168365 43177 110377747
Emotional disorder 36.61 12.53 78 168297 16082 110404842
Urinary tract infection 36.57 12.53 319 168056 325963 110094961
Divorced 36.25 12.53 9 168366 30 110420894
Rebound psychosis 36.23 12.53 16 168359 402 110420522
Suicide threat 36.13 12.53 11 168364 90 110420834
Pulmonary valve incompetence 35.88 12.53 31 168344 2655 110418269
Psychotic behaviour 35.86 12.53 24 168351 1401 110419523
Exhibitionism 35.81 12.53 10 168365 58 110420866
Acute myocardial infarction 35.69 12.53 45 168330 83732 110337192
Cataract 35.66 12.53 41 168334 79444 110341480
Myelodysplastic syndrome 35.39 12.53 7 168368 37477 110383447
Influenza 35.35 12.53 135 168240 168966 110251958
Suspiciousness 35.17 12.53 19 168356 748 110420176
Coordination abnormal 35.07 12.53 101 168274 25127 110395797
Road traffic accident 35.01 12.53 69 168306 107329 110313595
Distractibility 34.97 12.53 20 168355 881 110420043
Illusion 34.89 12.53 27 168348 1980 110418944
Rash erythematous 34.81 12.53 44 168331 81788 110339136
Taciturnity 34.66 12.53 7 168368 5 110420919
Dyspepsia 34.64 12.53 161 168214 190804 110230120
Morbid thoughts 34.60 12.53 20 168355 899 110420025
COVID-19 34.38 12.53 225 168150 244835 110176089
Vitamin B12 increased 34.32 12.53 27 168348 2028 110418896
Bladder dilatation 34.32 12.53 29 168346 2410 110418514
Bronchopulmonary aspergillosis 34.32 12.53 3 168372 29860 110391064
Juvenile idiopathic arthritis 34.27 12.53 44 168331 5963 110414961
Metastases to bone 33.85 12.53 4 168371 31368 110389556
Psoriasis 33.84 12.53 105 168270 139888 110281036
Injection site erythema 33.83 12.53 57 168318 94119 110326805
Concussion 33.76 12.53 62 168313 11476 110409448
Mycobacterial peritonitis 33.64 12.53 13 168362 230 110420694
Back injury 33.61 12.53 15 168360 47384 110373540
Thrombosis 33.57 12.53 72 168303 108590 110312334
Dry skin 33.53 12.53 71 168304 107582 110313342
Chronic kidney disease 33.53 12.53 40 168335 76251 110344673
Mycobacterium fortuitum infection 33.49 12.53 16 168359 484 110420440
Neuralgia 33.36 12.53 16 168359 48462 110372462
Post cholecystectomy syndrome 33.30 12.53 19 168356 833 110420091
Neglect of personal appearance 33.17 12.53 15 168360 399 110420525
Tumour lysis syndrome 33.05 12.53 4 168371 30797 110390127
Intellectual disability 33.05 12.53 26 168349 1953 110418971
Conversion disorder 32.98 12.53 28 168347 2342 110418582
Neutropenic sepsis 32.98 12.53 4 168371 30742 110390182
Birdshot chorioretinopathy 32.93 12.53 10 168365 81 110420843
COVID-19 pneumonia 32.91 12.53 8 168367 37135 110383789
Mucosal inflammation 32.89 12.53 60 168315 96081 110324843
Thermal burn 32.85 12.53 50 168325 7938 110412986
Blood cholesterol increased 32.81 12.53 157 168218 184628 110236296
Anaphylactic reaction 32.66 12.53 79 168296 114221 110306703
Paraesthesia oral 32.40 12.53 6 168369 33665 110387259
Fear 32.38 12.53 93 168282 23100 110397824
Bacteraemia 32.36 12.53 12 168363 42378 110378546
Accidental death 32.28 12.53 39 168336 4970 110415954
Gout 32.16 12.53 8 168367 36558 110384366
Sternal fracture 32.14 12.53 32 168343 3284 110417640
Nervousness 32.06 12.53 126 168249 36725 110384199
Diabetic coma 31.95 12.53 22 168353 1346 110419578
Premature labour 31.66 12.53 53 168322 9119 110411805
Patient restraint 31.61 12.53 10 168365 94 110420830
Dementia 31.46 12.53 113 168262 31560 110389364
Gaming disorder 31.45 12.53 7 168368 12 110420912
Bone marrow oedema syndrome 31.29 12.53 9 168366 59 110420865
Manic symptom 31.16 12.53 13 168362 283 110420641
Gastric ulcer 30.87 12.53 11 168364 39816 110381108
Respiratory disorder 30.76 12.53 38 168337 71344 110349580
Thrombotic microangiopathy 30.76 12.53 4 168371 29145 110391779
Disease recurrence 30.34 12.53 177 168198 60607 110360317
Full blood count decreased 30.29 12.53 6 168369 32093 110388831
Electroencephalogram abnormal 30.28 12.53 42 168333 6131 110414793
Syringe issue 30.20 12.53 53 168322 9472 110411452
Hypervolaemia 30.15 12.53 19 168356 49441 110371483
Chest discomfort 30.11 12.53 149 168226 173699 110247225
Rhinorrhoea 30.10 12.53 70 168305 102596 110318328
Hepatitis 30.10 12.53 57 168318 89997 110330927
Dry mouth 29.89 12.53 180 168195 199768 110221156
Bone pain 29.87 12.53 33 168342 65100 110355824
Screaming 29.83 12.53 37 168338 4844 110416080
Postural tremor 29.76 12.53 19 168356 1023 110419901
Dependence 29.58 12.53 28 168347 2701 110418223
Alcohol abuse 29.54 12.53 37 168338 4892 110416032
Adjusted calcium increased 29.52 12.53 9 168366 74 110420850
Injection site pruritus 29.48 12.53 21 168354 51237 110369687
Dementia with Lewy bodies 29.37 12.53 19 168356 1047 110419877
Slow speech 29.30 12.53 31 168344 3417 110417507
Nuchal rigidity 29.21 12.53 20 168355 1212 110419712
Ear pain 29.08 12.53 23 168352 53203 110367721
Oral candidiasis 28.97 12.53 16 168359 44744 110376180
Auditory disorder 28.85 12.53 21 168354 1403 110419521
Pneumothorax 28.65 12.53 9 168366 35276 110385648
Lung neoplasm malignant 28.63 12.53 8 168367 33834 110387090
Bundle branch block right 28.63 12.53 60 168315 12231 110408693
Rebound effect 28.53 12.53 67 168308 14739 110406185
Full blood count abnormal 28.45 12.53 26 168349 56026 110364898
Subdural haematoma 28.37 12.53 10 168365 36444 110384480
Lethargy 28.18 12.53 241 168134 93335 110327589
Pyramidal tract syndrome 28.13 12.53 17 168358 830 110420094
Congestive cardiomyopathy 28.12 12.53 65 168310 14154 110406770
High density lipoprotein decreased 28.11 12.53 39 168336 5694 110415230
Protrusion tongue 27.85 12.53 14 168361 474 110420450
Drug monitoring procedure not performed 27.83 12.53 20 168355 1310 110419614
Muscle spasms 27.71 12.53 280 168095 277877 110143047
Fungal infection 27.70 12.53 22 168353 50784 110370140
Drug-induced liver injury 27.66 12.53 92 168283 119975 110300949
Migraine 27.55 12.53 151 168224 171501 110249423
Rash maculo-papular 27.52 12.53 44 168331 74178 110346746
Drug screen false positive 27.31 12.53 20 168355 1349 110419575
Blood pressure systolic abnormal 27.24 12.53 3 168372 24847 110396077
Delusional perception 27.13 12.53 13 168362 396 110420528
Nodule 27.08 12.53 8 168367 32623 110388301
Hypocalcaemia 26.93 12.53 36 168339 65330 110355594
Initial insomnia 26.91 12.53 53 168322 10336 110410588
Hip fracture 26.75 12.53 10 168365 35141 110385783
Oligospermia 26.63 12.53 7 168368 31 110420893
Polyuria 26.60 12.53 73 168302 17665 110403259
Monocyte count increased 26.54 12.53 61 168314 13232 110407692
Verbal abuse 26.44 12.53 12 168363 322 110420602
Obstructive airways disorder 26.42 12.53 19 168356 46130 110374794
Excessive sexual fantasies 26.36 12.53 6 168369 12 110420912
Nephropathy toxic 26.22 12.53 5 168370 27473 110393451
Hypomagnesaemia 26.16 12.53 32 168343 60338 110360586
Troponin increased 26.08 12.53 102 168273 29664 110391260
Hypophosphataemia 26.00 12.53 9 168366 33173 110387751
Drug ineffective for unapproved indication 25.98 12.53 255 168120 102583 110318341
Hypokalaemia 25.84 12.53 167 168208 182281 110238643
Leukocytosis 25.75 12.53 155 168220 53673 110367251
Confusional arousal 25.72 12.53 10 168365 180 110420744
Cystitis 25.58 12.53 38 168337 65998 110354926
Theft 25.53 12.53 11 168364 260 110420664
Ejaculation disorder 25.48 12.53 14 168361 570 110420354
Breast feeding 25.30 12.53 15 168360 707 110420217
Antisocial behaviour 25.22 12.53 16 168359 852 110420072
Grimacing 25.19 12.53 16 168359 854 110420070
Clostridium difficile colitis 25.10 12.53 18 168357 43760 110377164
Glomerular filtration rate increased 25.08 12.53 22 168353 1923 110419001
Osteonecrosis 25.01 12.53 10 168365 33731 110387193
Antidepressant drug level increased 24.78 12.53 14 168361 602 110420322
Granulocyte count increased 24.71 12.53 22 168353 1961 110418963
Therapy change 24.69 12.53 50 168325 9947 110410977
Diabetic hyperosmolar coma 24.66 12.53 16 168359 886 110420038
Coloboma 24.64 12.53 6 168369 18 110420906
Tongue spasm 24.59 12.53 9 168366 136 110420788
Polyneuropathy 24.54 12.53 9 168366 32003 110388921
Personal relationship issue 24.48 12.53 10 168365 206 110420718
Ear infection 24.40 12.53 36 168339 62696 110358228
Metastases to central nervous system 24.40 12.53 3 168372 22814 110398110
Dehydration 24.39 12.53 290 168085 279221 110141703
Lactic acidosis 24.33 12.53 67 168308 92744 110328180
Non-high-density lipoprotein cholesterol increased 24.15 12.53 12 168363 396 110420528
Cerebrovascular accident 24.14 12.53 169 168206 181115 110239809
Hypertension 24.03 12.53 592 167783 509492 109911432
Poriomania 23.95 12.53 10 168365 218 110420706
Hemiparesis 23.95 12.53 19 168356 43884 110377040
Hereditary ataxia 23.94 12.53 6 168369 21 110420903
Uterine dilation and curettage 23.92 12.53 14 168361 644 110420280
Hunger 23.92 12.53 39 168336 6565 110414359
Sluggishness 23.85 12.53 42 168333 7525 110413399
Dysphemia 23.71 12.53 30 168345 4007 110416917
Electroconvulsive therapy 23.61 12.53 8 168367 95 110420829
Neutrophilia 23.57 12.53 50 168325 10279 110410645
Chronic obstructive pulmonary disease 23.56 12.53 86 168289 109072 110311852
Muscle tightness 23.39 12.53 62 168313 14700 110406224
Respiratory tract infection 23.35 12.53 46 168329 71571 110349353
Adverse reaction 23.23 12.53 8 168367 29586 110391338
Pulmonary embolism 23.20 12.53 457 167918 214017 110206907
Pregnancy with implant contraceptive 23.20 12.53 23 168352 2349 110418575
Libido disorder 23.08 12.53 11 168364 331 110420593
Walking aid user 23.02 12.53 5 168370 25070 110395854
High-grade B-cell lymphoma 22.88 12.53 10 168365 245 110420679
Self-medication 22.84 12.53 37 168338 6195 110414729
Communication disorder 22.82 12.53 33 168342 5006 110415918
Alcohol use disorder 22.81 12.53 7 168368 59 110420865
Respiratory failure 22.60 12.53 214 168161 215118 110205806
Renal impairment 22.56 12.53 181 168194 188264 110232660
Intermenstrual bleeding 22.52 12.53 39 168336 6895 110414029
Joint dislocation 22.45 12.53 12 168363 34178 110386746
Delusion of parasitosis 22.43 12.53 10 168365 257 110420667
Candida infection 22.37 12.53 24 168351 47985 110372939
Intention tremor 22.36 12.53 15 168360 879 110420045
Musculoskeletal chest pain 22.30 12.53 8 168367 28839 110392085
Compulsive hoarding 22.21 12.53 7 168368 65 110420859
Sleep disorder due to a general medical condition 22.19 12.53 28 168347 52084 110368840
Hypometabolism 22.18 12.53 9 168366 182 110420742
Erection increased 22.17 12.53 11 168364 362 110420562
Joint stiffness 22.09 12.53 43 168332 67200 110353724
Imprisonment 22.08 12.53 14 168361 745 110420179
Blood pressure diastolic abnormal 22.03 12.53 6 168369 25809 110395115
Complicated fracture 21.96 12.53 4 168371 0 110420924
Therapy partial responder 21.91 12.53 113 168262 36948 110383976
Excessive masturbation 21.85 12.53 8 168367 121 110420803
Pulmonary mass 21.83 12.53 15 168360 37286 110383638
Eating disorder 21.78 12.53 99 168276 30759 110390165
Skin exfoliation 21.71 12.53 65 168310 87586 110333338
Anaphylactic shock 21.63 12.53 28 168347 51518 110369406
Decreased activity 21.52 12.53 50 168325 10924 110410000
Target skin lesion 21.51 12.53 10 168365 284 110420640
Bacterial infection 21.47 12.53 23 168352 46013 110374911
Mouth ulceration 21.41 12.53 25 168350 48113 110372811
Basilar artery occlusion 21.32 12.53 10 168365 290 110420634
Myocarditis septic 21.31 12.53 6 168369 36 110420888
Aspartate aminotransferase 21.26 12.53 15 168360 954 110419970
Procedural pain 21.22 12.53 14 168361 35551 110385373
Laryngitis 21.14 12.53 20 168355 42391 110378533
Chronic sinusitis 21.09 12.53 6 168369 25078 110395846
Hyperammonaemia 21.08 12.53 57 168318 13675 110407249
Pseudomonas infection 21.07 12.53 8 168367 27845 110393079
Osteomyelitis 21.04 12.53 15 168360 36585 110384339
Myocardial infarction 20.98 12.53 189 168186 191894 110229030
Bladder cancer 20.90 12.53 3 168372 20289 110400635
Hypoalbuminaemia 20.81 12.53 9 168366 28965 110391959
Bronchospasm 20.77 12.53 10 168365 30229 110390695
Blood immunoglobulin A increased 20.75 12.53 18 168357 1550 110419374
Rales 20.65 12.53 6 168369 24733 110396191
CADASIL 20.65 12.53 6 168369 41 110420883
Neoplasm progression 20.62 12.53 42 168333 64553 110356371
Body dysmorphic disorder 20.57 12.53 11 168364 424 110420500
Pulmonary arterial hypertension 20.56 12.53 12 168363 32556 110388368
Nephrectasia 20.54 12.53 5 168370 15 110420909
Nephrolithiasis 20.34 12.53 44 168331 66168 110354756
Shock haemorrhagic 20.32 12.53 8 168367 27239 110393685
Angina pectoris 20.32 12.53 40 168335 62255 110358669
Electric shock 20.28 12.53 19 168356 1809 110419115
Iatrogenic injury 20.22 12.53 18 168357 1605 110419319
Respiratory arrest 20.18 12.53 155 168220 58144 110362780
White blood cell count increased 20.18 12.53 231 168144 96611 110324313
Selective mutism 20.16 12.53 7 168368 90 110420834
Platelet count decreased 20.14 12.53 239 168136 230204 110190720
Blood creatine phosphokinase 20.05 12.53 10 168365 333 110420591
Hypotonia 19.95 12.53 61 168314 15684 110405240
Hypertriglyceridaemia 19.92 12.53 62 168313 16092 110404832
Asphyxia 19.84 12.53 57 168318 14158 110406766
Abortion threatened 19.84 12.53 11 168364 456 110420468
Duodenal ulcer 19.83 12.53 3 168372 19511 110401413
Cholestasis of pregnancy 19.80 12.53 16 168359 1249 110419675
Transfusion 19.80 12.53 7 168368 25465 110395459
Haematotoxicity 19.77 12.53 4 168371 21078 110399846
Drug effect less than expected 19.76 12.53 38 168337 7282 110413642
Ulcer haemorrhage 19.73 12.53 5 168370 22566 110398358
Shoplifting 19.72 12.53 4 168371 3 110420921
Persistent depressive disorder 19.64 12.53 17 168358 1460 110419464
Fear of weight gain 19.63 12.53 5 168370 19 110420905
Affective ambivalence 19.63 12.53 5 168370 19 110420905
Blood pressure fluctuation 19.62 12.53 54 168321 74770 110346154
Deja vu 19.62 12.53 7 168368 98 110420826
Activated partial thromboplastin time prolonged 19.47 12.53 5 168370 22363 110398561
Faeces discoloured 19.41 12.53 14 168361 33934 110386990
Suspected suicide 19.37 12.53 59 168316 15140 110405784
Renal hypertension 19.28 12.53 9 168366 258 110420666
Facial nerve disorder 19.27 12.53 13 168362 769 110420155
Upper gastrointestinal haemorrhage 19.24 12.53 29 168346 50067 110370857
Oral herpes 19.20 12.53 16 168359 36064 110384860
Locked-in syndrome 19.20 12.53 14 168361 938 110419986
Sexual abuse 19.12 12.53 9 168366 263 110420661
Twin pregnancy 19.12 12.53 14 168361 944 110419980
Foetal exposure during pregnancy 19.09 12.53 38 168337 7467 110413457
Nicotine dependence 19.09 12.53 16 168359 1315 110419609
Polyarthritis 19.08 12.53 3 168372 18960 110401964
Joint hyperextension 19.05 12.53 10 168365 371 110420553
Patient dissatisfaction with treatment 19.05 12.53 10 168365 371 110420553
Neuroleptic-induced deficit syndrome 19.05 12.53 5 168370 22 110420902
Helplessness 19.03 12.53 10 168365 372 110420552
Immunodeficiency common variable 18.87 12.53 12 168363 642 110420282
Hyperaldosteronism 18.85 12.53 12 168363 643 110420281
Femur fracture 18.82 12.53 24 168351 44445 110376479
Arrhythmia 18.80 12.53 175 168200 69400 110351524
Haemorrhoids 18.76 12.53 16 168359 35656 110385268
Respiratory tract congestion 18.61 12.53 12 168363 30845 110390079
Benign ethnic neutropenia 18.59 12.53 7 168368 115 110420809
Narcolepsy 18.58 12.53 17 168358 1571 110419353
Body mass index decreased 18.48 12.53 13 168362 823 110420101
Tubulointerstitial nephritis 18.46 12.53 34 168341 54250 110366674
Trichotillomania 18.41 12.53 8 168367 193 110420731
Breath sounds abnormal 18.07 12.53 8 168367 25396 110395528
Long QT syndrome 18.06 12.53 36 168339 7082 110413842
Nightmare 18.01 12.53 111 168264 38752 110382172
Drug resistance 17.94 12.53 147 168228 56227 110364697
Somatic symptom disorder 17.80 12.53 23 168352 3136 110417788
Immune thrombocytopenia 17.80 12.53 6 168369 22488 110398436
Panic attack 17.64 12.53 89 168286 28851 110392073
Ornithine transcarbamoylase deficiency 17.62 12.53 5 168370 31 110420893
Diabetes insipidus 17.60 12.53 34 168341 6536 110414388
Oesophagitis 17.54 12.53 11 168364 28704 110392220
Injection site bruising 17.52 12.53 32 168343 51231 110369693
Urate nephropathy 17.52 12.53 8 168367 218 110420706
Blood creatinine increased 17.43 12.53 186 168189 182703 110238221
Chemical burn 17.40 12.53 12 168363 736 110420188
Multiple drug therapy 17.37 12.53 38 168337 7976 110412948
Product quality issue 17.28 12.53 60 168315 77239 110343685
Dermatillomania 17.24 12.53 9 168366 330 110420594
Wrong patient received product 17.23 12.53 34 168341 6640 110414284
Tourette's disorder 17.08 12.53 6 168369 80 110420844
Incontinence 17.08 12.53 60 168315 16575 110404349
Device related infection 17.07 12.53 21 168354 39498 110381426
Violence-related symptom 16.88 12.53 13 168362 946 110419978
Glabellar reflex abnormal 16.86 12.53 5 168370 37 110420887
Merycism 16.85 12.53 9 168366 346 110420578
Sinus disorder 16.83 12.53 15 168360 32713 110388211
Squamous cell carcinoma of skin 16.69 12.53 3 168372 17200 110403724
Muscle spasticity 16.69 12.53 18 168357 35897 110385027
White blood cells urine positive 16.68 12.53 36 168339 7488 110413436
Product reconstitution quality issue 16.62 12.53 9 168366 356 110420568
Pulmonary alveolar haemorrhage 16.61 12.53 5 168370 20145 110400779
Impaired self-care 16.58 12.53 20 168355 2544 110418380
Skin necrosis 16.57 12.53 6 168369 21506 110399418
Haemorrhage intracranial 16.49 12.53 12 168363 28957 110391967
Laboratory test abnormal 16.46 12.53 26 168349 44053 110376871
Flight of ideas 16.46 12.53 12 168363 804 110420120
Localised infection 16.45 12.53 25 168350 43023 110377901
Gastroenteritis viral 16.43 12.53 14 168361 31212 110389712
Asocial behaviour 16.37 12.53 6 168369 91 110420833
Squamous cell carcinoma 16.31 12.53 4 168371 18459 110402465
Myositis 16.31 12.53 14 168361 31102 110389822
Hepatic failure 16.29 12.53 52 168323 68687 110352237
Morning sickness 16.25 12.53 12 168363 820 110420104
Excessive eye blinking 16.23 12.53 17 168358 1853 110419071
Foetal anticonvulsant syndrome 16.22 12.53 8 168367 260 110420664
Skin lesion 16.12 12.53 34 168341 51597 110369327
Emphysema 16.11 12.53 5 168370 19751 110401173
Pemphigoid 16.05 12.53 5 168370 19702 110401222
Inability to afford medication 16.04 12.53 25 168350 4051 110416873
Sneezing 16.04 12.53 15 168360 31969 110388955
Balance disorder 16.02 12.53 258 168117 116302 110304622
Female sexual dysfunction 16 12.53 5 168370 45 110420879
Staphylococcal bacteraemia 16 12.53 3 168372 16685 110404239
Glycogen storage disorder 15.96 12.53 4 168371 14 110420910
Mean cell haemoglobin concentration decreased 15.96 12.53 30 168345 5652 110415272
Therapeutic product effect incomplete 15.93 12.53 450 167925 223355 110197569
Abdominal pain lower 15.91 12.53 20 168355 37263 110383661
Chorea 15.85 12.53 22 168353 3213 110417711
Diet refusal 15.84 12.53 12 168363 852 110420072
Hyperbilirubinaemia 15.84 12.53 14 168361 30657 110390267
Sinus arrhythmia 15.82 12.53 18 168357 2152 110418772
Polyhydramnios 15.76 12.53 17 168358 1916 110419008
Prader-Willi syndrome 15.75 12.53 4 168371 15 110420909
Oropharyngeal pain 15.70 12.53 131 168244 135145 110285779
Posterior reversible encephalopathy syndrome 15.70 12.53 17 168358 33844 110387080
Hyporeflexia 15.66 12.53 25 168350 4135 110416789
Potentiating drug interaction 15.59 12.53 46 168329 11597 110409327
Haemophagocytic lymphohistiocytosis 15.59 12.53 15 168360 31544 110389380
Petechiae 15.58 12.53 8 168367 23309 110397615
Radiculopathy 15.58 12.53 5 168370 19331 110401593
Attention deficit hyperactivity disorder 15.57 12.53 26 168349 4465 110416459
Heart rate 15.54 12.53 8 168367 285 110420639
Somatic symptom disorder of pregnancy 15.53 12.53 6 168369 106 110420818
Menstruation irregular 15.53 12.53 30 168345 5767 110415157
Electrocardiogram abnormal 15.50 12.53 63 168312 18646 110402278
Product administration interrupted 15.49 12.53 45 168330 11247 110409677
Neuropsychiatric symptoms 15.48 12.53 14 168361 1274 110419650
Blood ketone body 15.45 12.53 7 168368 187 110420737
Waxy flexibility 15.36 12.53 8 168367 292 110420632
Sputum discoloured 15.36 12.53 12 168363 27933 110392991
Head banging 15.34 12.53 10 168365 558 110420366
Poisoning 15.34 12.53 86 168289 29019 110391905
Breath odour 15.34 12.53 17 168358 1975 110418949
Anuria 15.32 12.53 9 168366 24332 110396592
Amphetamines positive 15.29 12.53 8 168367 295 110420629
Foetal malformation 15.27 12.53 5 168370 53 110420871
Glucose tolerance impaired 15.27 12.53 41 168334 9796 110411128
Pleuritic pain 15.27 12.53 3 168372 16137 110404787
Photopsia 15.25 12.53 31 168344 6183 110414741
Post procedural complication 15.23 12.53 11 168364 26647 110394277
Ejaculation delayed 15.15 12.53 7 168368 196 110420728
Dyskinesia oesophageal 15.10 12.53 5 168370 55 110420869
Feeling abnormal 15.07 12.53 371 168004 180340 110240584
Angioedema 15.07 12.53 88 168287 98412 110322512
Echopraxia 15.02 12.53 5 168370 56 110420868
Alcoholism 14.96 12.53 23 168352 3684 110417240
Drug tolerance decreased 14.92 12.53 12 168363 27528 110393396
Breast discharge 14.84 12.53 12 168363 938 110419986
Epstein-Barr virus infection 14.82 12.53 5 168370 18733 110402191
Therapeutic product ineffective 14.74 12.53 19 168356 2585 110418339
Dysentery 14.73 12.53 14 168361 1357 110419567
Panic disorder 14.71 12.53 22 168353 3439 110417485
Urosepsis 14.67 12.53 15 168360 30660 110390264
Food allergy 14.64 12.53 6 168369 19942 110400982
Gender dysphoria 14.56 12.53 5 168370 62 110420862
Feeling of despair 14.54 12.53 23 168352 3775 110417149
Vasculitis 14.53 12.53 20 168355 35853 110385071
Angle closure glaucoma 14.53 12.53 22 168353 3477 110417447
Lower gastrointestinal haemorrhage 14.51 12.53 5 168370 18481 110402443
Disruptive mood dysregulation disorder 14.50 12.53 4 168371 22 110420902
Skin disorder 14.48 12.53 27 168348 42886 110378038
Diverticulum 14.45 12.53 3 168372 15523 110405401
Pulmonary hypertension 14.37 12.53 40 168335 55180 110365744
Anorgasmia 14.35 12.53 15 168360 1631 110419293
Atelectasis 14.34 12.53 21 168354 36691 110384233
Hot flush 14.26 12.53 52 168323 65984 110354940
Limb injury 14.25 12.53 22 168353 37614 110383310
Blood thyroid stimulating hormone decreased 14.21 12.53 33 168342 7206 110413718
Meningitis streptococcal 14.20 12.53 7 168368 227 110420697
Delusional disorder, erotomanic type 14.14 12.53 5 168370 68 110420856
Pulseless electrical activity 14.10 12.53 4 168371 16753 110404171
Premature baby 14.09 12.53 26 168349 4829 110416095
Condition aggravated 14.04 12.53 1300 167075 733536 109687388
Spleen congestion 14.01 12.53 9 168366 490 110420434
Myoglobin blood increased 14.00 12.53 24 168351 4208 110416716
Urine amphetamine positive 14.00 12.53 6 168369 140 110420784
Cholangitis infective 13.96 12.53 11 168364 828 110420096
Kleptomania 13.94 12.53 4 168371 26 110420898
Gastritis 13.90 12.53 39 168336 53660 110367264
Metastases to lung 13.86 12.53 9 168366 23054 110397870
Normal newborn 13.81 12.53 68 168307 21828 110399096
Metastases to lymph nodes 13.79 12.53 3 168372 15029 110405895
Vaginal discharge 13.79 12.53 5 168370 17903 110403021
Rheumatoid factor increased 13.75 12.53 18 168357 2487 110418437
Energy increased 13.72 12.53 22 168353 3652 110417272
Pulmonary haemorrhage 13.72 12.53 4 168371 16452 110404472
Sleep apnoea syndrome 13.70 12.53 107 168268 40340 110380584
Macular degeneration 13.65 12.53 8 168367 21651 110399273
Oxygen saturation decreased 13.64 12.53 163 168212 156819 110264105
Skin cancer 13.63 12.53 5 168370 17779 110403145
Panic reaction 13.60 12.53 27 168348 5295 110415629
Self esteem inflated 13.53 12.53 3 168372 5 110420919
Stiff tongue 13.53 12.53 3 168372 5 110420919
Blood glucose decreased 13.52 12.53 84 168291 29404 110391520
Scrotal haematoma 13.52 12.53 5 168370 78 110420846
Autoimmune hepatitis 13.49 12.53 3 168372 14801 110406123
Embolism venous 13.47 12.53 26 168349 4997 110415927
Haemorrhage 13.46 12.53 101 168274 106591 110314333
Ejaculation failure 13.44 12.53 8 168367 380 110420544
Pituitary tumour benign 13.41 12.53 19 168356 2828 110418096
Musculoskeletal disorder 13.41 12.53 9 168366 22655 110398269
Chorioretinopathy 13.39 12.53 17 168358 2278 110418646
Escherichia infection 13.38 12.53 10 168365 23806 110397118
Myopathy 13.37 12.53 11 168364 24949 110395975
Therapeutic product effective for unapproved indication 13.36 12.53 6 168369 157 110420767
Tendonitis 13.35 12.53 12 168363 26071 110394853
Gait disturbance 13.32 12.53 534 167841 277674 110143250
Sleep deficit 13.29 12.53 15 168360 1777 110419147
Thought blocking 13.28 12.53 7 168368 262 110420662
Device difficult to use 13.26 12.53 6 168369 18799 110402125
Lipase increased 13.25 12.53 60 168315 18612 110402312
Dropped head syndrome 13.24 12.53 9 168366 539 110420385
Paralogism 13.22 12.53 4 168371 32 110420892
Clonus 13.20 12.53 36 168339 8680 110412244
Judgement impaired 13.20 12.53 13 168362 1317 110419607
Intrusive thoughts 13.19 12.53 10 168365 711 110420213
Hypernatraemia 13.18 12.53 58 168317 17775 110403149
Middle insomnia 13.17 12.53 64 168311 20438 110400486
CYP2D6 polymorphism 13.12 12.53 5 168370 85 110420839
Sexually transmitted disease 13.12 12.53 6 168369 164 110420760
Bone disorder 13.11 12.53 8 168367 21184 110399740
Pregnancy 13.07 12.53 127 168248 50940 110369984
Cytopenia 13.01 12.53 16 168359 30100 110390824
Hyponatriuria 13.00 12.53 4 168371 34 110420890
Induced labour 13.00 12.53 11 168364 916 110420008
Victim of abuse 12.96 12.53 5 168370 88 110420836
Upper-airway cough syndrome 12.95 12.53 4 168371 15853 110405071
Hypoacusis 12.91 12.53 21 168354 35170 110385754
Maternal exposure timing unspecified 12.91 12.53 8 168367 21005 110399919
Pseudodementia 12.90 12.53 4 168371 35 110420889
Dermatitis 12.88 12.53 14 168361 27823 110393101
Confusional state 12.87 12.53 853 167522 467827 109953097
Swelling face 12.82 12.53 85 168290 92236 110328688
Pica 12.81 12.53 5 168370 91 110420833
Back disorder 12.80 12.53 8 168367 20914 110400010
Transient ischaemic attack 12.78 12.53 52 168323 63930 110356994
Dysbiosis 12.77 12.53 16 168359 2116 110418808
Organising pneumonia 12.75 12.53 3 168372 14240 110406684
Abnormal weight gain 12.73 12.53 21 168354 3570 110417354
Maternal exposure during breast feeding 12.69 12.53 23 168352 4215 110416709
Cataplexy 12.68 12.53 12 168363 1157 110419767
Premature delivery 12.66 12.53 85 168290 30547 110390377
Hyperosmolar state 12.61 12.53 10 168365 760 110420164

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Dehydration 28.56 24.14 31 1206 472 112244
Enterococcal sepsis 28.56 24.14 10 1227 10 112706
Right ventricular false tendon 28.56 24.14 10 1227 10 112706

Pharmacologic Action:

SourceCodeDescription
ATC N05AX12 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Other antipsychotics
FDA EPC N0000175430 Atypical Antipsychotic
MeSH PA D000928 Antidepressive Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D011619 Psychotropic Drugs
MeSH PA D012702 Serotonin Antagonists
MeSH PA D014150 Antipsychotic Agents
MeSH PA D015259 Dopamine Agents
MeSH PA D017366 Serotonin Receptor Agonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018490 Serotonin Agents
MeSH PA D018491 Dopamine Agonists
MeSH PA D018492 Dopamine Antagonists
MeSH PA D058825 Serotonin 5-HT1 Receptor Agonists
MeSH PA D058830 Serotonin 5-HT2 Receptor Antagonists
MeSH PA D065127 Dopamine D2 Receptor Antagonists
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:35941 serotonergic agonist
CHEBI has role CHEBI:37955 H<small><sub>1</sub></small>-receptor antagonist
CHEBI has role CHEBI:49103 drug metabolite
CHEBI has role CHEBI:50779 appetite enhancer
CHEBI has role CHEBI:65191 second generation antipsychotic

Related Drugs by ATC class:

N05AX Other antipsychotics 11 drugs
brexpiprazolecariprazineiloperidonemosapraminepaliperidonepimavanserinprothipendylrisperidonetrospiumxanomelinezotepine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Mixed bipolar I disorder indication 16506000 DOID:3312
Schizophrenia indication 58214004 DOID:5419
Bipolar disorder in remission indication 85248005
Bipolar affective disorder, current episode manic indication 191618007
Infantile autism indication 408857007
Agitation associated with Bipolar Mania indication
Depression Treatment Adjunct indication
Agitation associated with Schizophrenia indication
Suicidal thoughts contraindication 6471006
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Agranulocytosis contraindication 17182001 DOID:12987
Myocardial infarction contraindication 22298006 DOID:5844
Alzheimer's disease contraindication 26929004 DOID:10652
Orthostatic hypotension contraindication 28651003
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Hyperlipidemia contraindication 55822004 DOID:1168
Cerebrovascular disease contraindication 62914000 DOID:6713
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperglycemia contraindication 80394007 DOID:4195
Leukopenia contraindication 84828003 DOID:615
Tardive dyskinesia contraindication 102449007
Seizure disorder contraindication 128613002
Metabolic syndrome X contraindication 237602007 DOID:14221
Esophageal dysmotility contraindication 266434009 DOID:9192
Neutropenic disorder contraindication 303011007 DOID:1227
At risk for aspiration contraindication 371736008
Impaired cognition contraindication 386806002
Breastfeeding (mother) contraindication 413712001
Myocardial ischemia contraindication 414795007 DOID:3393
Obesity contraindication 414916001 DOID:9970




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.84 Basic
pKa2 0.67 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
10MG ABILIFY OTSUKA N021436 Nov. 15, 2002 RX TABLET ORAL 9125939 July 28, 2026 ACUTE TREATMENT OF MANIC AND MIXED EPISODES ASSOCIATED WITH BIPOLAR I DISORDER
15MG ABILIFY OTSUKA N021436 Nov. 15, 2002 RX TABLET ORAL 9125939 July 28, 2026 ACUTE TREATMENT OF MANIC AND MIXED EPISODES ASSOCIATED WITH BIPOLAR I DISORDER
20MG ABILIFY OTSUKA N021436 Nov. 15, 2002 RX TABLET ORAL 9125939 July 28, 2026 ACUTE TREATMENT OF MANIC AND MIXED EPISODES ASSOCIATED WITH BIPOLAR I DISORDER
2MG ABILIFY OTSUKA N021436 Nov. 15, 2002 RX TABLET ORAL 9125939 July 28, 2026 ACUTE TREATMENT OF MANIC AND MIXED EPISODES ASSOCIATED WITH BIPOLAR I DISORDER
30MG ABILIFY OTSUKA N021436 Nov. 15, 2002 RX TABLET ORAL 9125939 July 28, 2026 ACUTE TREATMENT OF MANIC AND MIXED EPISODES ASSOCIATED WITH BIPOLAR I DISORDER
5MG ABILIFY OTSUKA N021436 Nov. 15, 2002 RX TABLET ORAL 9125939 July 28, 2026 ACUTE TREATMENT OF MANIC AND MIXED EPISODES ASSOCIATED WITH BIPOLAR I DISORDER
10MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** ABILIFY OTSUKA N021729 June 7, 2006 DISCN TABLET, ORALLY DISINTEGRATING ORAL 9125939 July 28, 2026 ACUTE TREATMENT OF MANIC AND MIXED EPISODES ASSOCIATED WITH BIPOLAR I DISORDER
15MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** ABILIFY OTSUKA N021729 June 7, 2006 DISCN TABLET, ORALLY DISINTEGRATING ORAL 9125939 July 28, 2026 ACUTE TREATMENT OF MANIC AND MIXED EPISODES ASSOCIATED WITH BIPOLAR I DISORDER
10MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 9125939 July 28, 2026 ACUTE TREATMENT OF MANIC AND MIXED EPISODES ASSOCIATED WITH BIPOLAR I DISORDER
15MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 9125939 July 28, 2026 ACUTE TREATMENT OF MANIC AND MIXED EPISODES ASSOCIATED WITH BIPOLAR I DISORDER
20MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 9125939 July 28, 2026 ACUTE TREATMENT OF MANIC AND MIXED EPISODES ASSOCIATED WITH BIPOLAR I DISORDER
2MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 9125939 July 28, 2026 ACUTE TREATMENT OF MANIC AND MIXED EPISODES ASSOCIATED WITH BIPOLAR I DISORDER
30MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 9125939 July 28, 2026 ACUTE TREATMENT OF MANIC AND MIXED EPISODES ASSOCIATED WITH BIPOLAR I DISORDER
5MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 9125939 July 28, 2026 ACUTE TREATMENT OF MANIC AND MIXED EPISODES ASSOCIATED WITH BIPOLAR I DISORDER
10MG ABILIFY OTSUKA N021436 Nov. 15, 2002 RX TABLET ORAL 8759350 March 2, 2027 ADJUNCTIVE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD)
15MG ABILIFY OTSUKA N021436 Nov. 15, 2002 RX TABLET ORAL 8759350 March 2, 2027 ADJUNCTIVE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD)
20MG ABILIFY OTSUKA N021436 Nov. 15, 2002 RX TABLET ORAL 8759350 March 2, 2027 ADJUNCTIVE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD)
2MG ABILIFY OTSUKA N021436 Nov. 15, 2002 RX TABLET ORAL 8759350 March 2, 2027 ADJUNCTIVE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD)
30MG ABILIFY OTSUKA N021436 Nov. 15, 2002 RX TABLET ORAL 8759350 March 2, 2027 ADJUNCTIVE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD)
5MG ABILIFY OTSUKA N021436 Nov. 15, 2002 RX TABLET ORAL 8759350 March 2, 2027 ADJUNCTIVE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD)
1MG/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** ABILIFY OTSUKA N021713 Dec. 10, 2004 DISCN SOLUTION ORAL 8759350 March 2, 2027 ADJUNCTIVE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD)
10MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** ABILIFY OTSUKA N021729 June 7, 2006 DISCN TABLET, ORALLY DISINTEGRATING ORAL 8759350 March 2, 2027 ADJUNCTIVE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD)
15MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** ABILIFY OTSUKA N021729 June 7, 2006 DISCN TABLET, ORALLY DISINTEGRATING ORAL 8759350 March 2, 2027 ADJUNCTIVE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD)
10MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8759350 March 2, 2027 ADJUNCTIVE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD)
15MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8759350 March 2, 2027 ADJUNCTIVE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD)
20MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8759350 March 2, 2027 ADJUNCTIVE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD)
2MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8759350 March 2, 2027 ADJUNCTIVE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD)
30MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8759350 March 2, 2027 ADJUNCTIVE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD)
5MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8759350 March 2, 2027 ADJUNCTIVE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD)
10MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 9444503 Nov. 19, 2027 METHOD OF USING A RECEIVER TO IDENTIFY A SIGNAL FROM A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION THROUGH THE BODY OF A PATIENT
15MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 9444503 Nov. 19, 2027 METHOD OF USING A RECEIVER TO IDENTIFY A SIGNAL FROM A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION THROUGH THE BODY OF A PATIENT
20MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 9444503 Nov. 19, 2027 METHOD OF USING A RECEIVER TO IDENTIFY A SIGNAL FROM A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION THROUGH THE BODY OF A PATIENT
2MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 9444503 Nov. 19, 2027 METHOD OF USING A RECEIVER TO IDENTIFY A SIGNAL FROM A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION THROUGH THE BODY OF A PATIENT
30MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 9444503 Nov. 19, 2027 METHOD OF USING A RECEIVER TO IDENTIFY A SIGNAL FROM A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION THROUGH THE BODY OF A PATIENT
5MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 9444503 Nov. 19, 2027 METHOD OF USING A RECEIVER TO IDENTIFY A SIGNAL FROM A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION THROUGH THE BODY OF A PATIENT
10MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8674825 April 9, 2029 METHOD OF USING A RECEIVER TO RECEIVE A SIGNAL FROM A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION THROUGH THE BODY OF A PATIENT
15MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8674825 April 9, 2029 METHOD OF USING A RECEIVER TO RECEIVE A SIGNAL FROM A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION THROUGH THE BODY OF A PATIENT
20MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8674825 April 9, 2029 METHOD OF USING A RECEIVER TO RECEIVE A SIGNAL FROM A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION THROUGH THE BODY OF A PATIENT
2MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8674825 April 9, 2029 METHOD OF USING A RECEIVER TO RECEIVE A SIGNAL FROM A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION THROUGH THE BODY OF A PATIENT
30MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8674825 April 9, 2029 METHOD OF USING A RECEIVER TO RECEIVE A SIGNAL FROM A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION THROUGH THE BODY OF A PATIENT
5MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8674825 April 9, 2029 METHOD OF USING A RECEIVER TO RECEIVE A SIGNAL FROM A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION THROUGH THE BODY OF A PATIENT
10MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8956288 July 6, 2029 METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
15MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8956288 July 6, 2029 METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
20MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8956288 July 6, 2029 METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
2MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8956288 July 6, 2029 METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
30MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8956288 July 6, 2029 METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
5MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8956288 July 6, 2029 METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
10MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8945005 Aug. 19, 2029 METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
15MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8945005 Aug. 19, 2029 METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
20MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8945005 Aug. 19, 2029 METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
2MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8945005 Aug. 19, 2029 METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
30MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8945005 Aug. 19, 2029 METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
5MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8945005 Aug. 19, 2029 METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
10MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8847766 March 29, 2030 METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
15MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8847766 March 29, 2030 METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
20MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8847766 March 29, 2030 METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
2MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8847766 March 29, 2030 METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
30MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8847766 March 29, 2030 METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
5MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8847766 March 29, 2030 METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
10MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8547248 Dec. 18, 2030 METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
15MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8547248 Dec. 18, 2030 METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
20MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8547248 Dec. 18, 2030 METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
2MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8547248 Dec. 18, 2030 METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
30MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8547248 Dec. 18, 2030 METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
5MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 8547248 Dec. 18, 2030 METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
720MG/2.4ML (300MG/ML) ABILIFY ASIMTUFII OTSUKA N217006 April 27, 2023 RX SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10517951 April 23, 2033 MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
720MG/2.4ML (300MG/ML) ABILIFY ASIMTUFII OTSUKA N217006 April 27, 2023 RX SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10517951 April 23, 2033 TREATMENT OF SCHIZOPHRENIA
720MG/2.4ML (300MG/ML) ABILIFY ASIMTUFII OTSUKA N217006 April 27, 2023 RX SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11097007 April 23, 2033 MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
720MG/2.4ML (300MG/ML) ABILIFY ASIMTUFII OTSUKA N217006 April 27, 2023 RX SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11097007 April 23, 2033 TREATMENT OF SCHIZOPHRENIA
720MG/2.4ML (300MG/ML) ABILIFY ASIMTUFII OTSUKA N217006 April 27, 2023 RX SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11638757 April 23, 2033 MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
720MG/2.4ML (300MG/ML) ABILIFY ASIMTUFII OTSUKA N217006 April 27, 2023 RX SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11638757 April 23, 2033 TREATMENT OF SCHIZOPHRENIA
720MG/2.4ML (300MG/ML) ABILIFY ASIMTUFII OTSUKA N217006 April 27, 2023 RX SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 12016927 April 23, 2033 MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
720MG/2.4ML (300MG/ML) ABILIFY ASIMTUFII OTSUKA N217006 April 27, 2023 RX SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 12016927 April 23, 2033 TREATMENT OF SCHIZOPHRENIA
960MG/3.2ML (300MG/ML) ABILIFY ASIMTUFII OTSUKA N217006 April 27, 2023 RX SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10517951 April 23, 2033 MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
960MG/3.2ML (300MG/ML) ABILIFY ASIMTUFII OTSUKA N217006 April 27, 2023 RX SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10517951 April 23, 2033 TREATMENT OF SCHIZOPHRENIA
960MG/3.2ML (300MG/ML) ABILIFY ASIMTUFII OTSUKA N217006 April 27, 2023 RX SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11097007 April 23, 2033 MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
960MG/3.2ML (300MG/ML) ABILIFY ASIMTUFII OTSUKA N217006 April 27, 2023 RX SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11097007 April 23, 2033 TREATMENT OF SCHIZOPHRENIA
960MG/3.2ML (300MG/ML) ABILIFY ASIMTUFII OTSUKA N217006 April 27, 2023 RX SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11638757 April 23, 2033 MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
960MG/3.2ML (300MG/ML) ABILIFY ASIMTUFII OTSUKA N217006 April 27, 2023 RX SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11638757 April 23, 2033 TREATMENT OF SCHIZOPHRENIA
960MG/3.2ML (300MG/ML) ABILIFY ASIMTUFII OTSUKA N217006 April 27, 2023 RX SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 12016927 April 23, 2033 MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
960MG/3.2ML (300MG/ML) ABILIFY ASIMTUFII OTSUKA N217006 April 27, 2023 RX SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 12016927 April 23, 2033 TREATMENT OF SCHIZOPHRENIA
300MG ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Sept. 29, 2014 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10980803 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA
300MG ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Sept. 29, 2014 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10980803 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
300MG ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Sept. 29, 2014 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11154553 Sept. 24, 2033 MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
300MG ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Sept. 29, 2014 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11154553 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA
300MG ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Sept. 29, 2014 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11154553 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
300MG ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Sept. 29, 2014 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11344547 Sept. 24, 2033 MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
300MG ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Sept. 29, 2014 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11344547 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA
300MG ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Sept. 29, 2014 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11344547 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
300MG ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Sept. 29, 2014 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11400087 Sept. 24, 2033 MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
300MG ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Sept. 29, 2014 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11400087 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA
300MG ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Sept. 29, 2014 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11400087 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
300MG/VIAL ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Feb. 28, 2013 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10980803 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA
300MG/VIAL ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Feb. 28, 2013 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10980803 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
300MG/VIAL ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Feb. 28, 2013 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11154553 Sept. 24, 2033 MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
300MG/VIAL ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Feb. 28, 2013 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11154553 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA
300MG/VIAL ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Feb. 28, 2013 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11154553 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
300MG/VIAL ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Feb. 28, 2013 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11344547 Sept. 24, 2033 MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
300MG/VIAL ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Feb. 28, 2013 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11344547 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA
300MG/VIAL ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Feb. 28, 2013 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11344547 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
300MG/VIAL ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Feb. 28, 2013 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11400087 Sept. 24, 2033 MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
300MG/VIAL ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Feb. 28, 2013 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11400087 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA
300MG/VIAL ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Feb. 28, 2013 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11400087 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
400MG ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Sept. 29, 2014 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10980803 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA
400MG ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Sept. 29, 2014 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10980803 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
400MG ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Sept. 29, 2014 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11154553 Sept. 24, 2033 MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
400MG ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Sept. 29, 2014 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11154553 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA
400MG ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Sept. 29, 2014 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11154553 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
400MG ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Sept. 29, 2014 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11344547 Sept. 24, 2033 MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
400MG ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Sept. 29, 2014 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11344547 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA
400MG ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Sept. 29, 2014 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11344547 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
400MG ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Sept. 29, 2014 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11400087 Sept. 24, 2033 MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
400MG ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Sept. 29, 2014 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11400087 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA
400MG ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Sept. 29, 2014 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11400087 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
400MG/VIAL ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Feb. 28, 2013 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10980803 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA
400MG/VIAL ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Feb. 28, 2013 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10980803 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
400MG/VIAL ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Feb. 28, 2013 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11154553 Sept. 24, 2033 MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
400MG/VIAL ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Feb. 28, 2013 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11154553 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA
400MG/VIAL ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Feb. 28, 2013 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11154553 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
400MG/VIAL ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Feb. 28, 2013 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11344547 Sept. 24, 2033 MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
400MG/VIAL ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Feb. 28, 2013 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11344547 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA
400MG/VIAL ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Feb. 28, 2013 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11344547 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
400MG/VIAL ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Feb. 28, 2013 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11400087 Sept. 24, 2033 MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
400MG/VIAL ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Feb. 28, 2013 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11400087 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA
400MG/VIAL ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Feb. 28, 2013 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 11400087 Sept. 24, 2033 TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
10MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 9268909 Oct. 15, 2033 METHOD OF USING A LOGIC CIRCUIT TO STABILIZE BATTERY VOLTAGE SUPPLIED TO A SENSOR EMBEDDED WITH A TABLET AND THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
15MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 9268909 Oct. 15, 2033 METHOD OF USING A LOGIC CIRCUIT TO STABILIZE BATTERY VOLTAGE SUPPLIED TO A SENSOR EMBEDDED WITH A TABLET AND THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
20MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 9268909 Oct. 15, 2033 METHOD OF USING A LOGIC CIRCUIT TO STABILIZE BATTERY VOLTAGE SUPPLIED TO A SENSOR EMBEDDED WITH A TABLET AND THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
2MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 9268909 Oct. 15, 2033 METHOD OF USING A LOGIC CIRCUIT TO STABILIZE BATTERY VOLTAGE SUPPLIED TO A SENSOR EMBEDDED WITH A TABLET AND THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
30MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 9268909 Oct. 15, 2033 METHOD OF USING A LOGIC CIRCUIT TO STABILIZE BATTERY VOLTAGE SUPPLIED TO A SENSOR EMBEDDED WITH A TABLET AND THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
5MG ABILIFY MYCITE KIT OTSUKA N207202 Nov. 13, 2017 DISCN TABLET ORAL 9268909 Oct. 15, 2033 METHOD OF USING A LOGIC CIRCUIT TO STABILIZE BATTERY VOLTAGE SUPPLIED TO A SENSOR EMBEDDED WITH A TABLET AND THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
300MG ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Sept. 29, 2014 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10525057 March 8, 2034 MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR 1 DISORDER
300MG ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Sept. 29, 2014 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10525057 March 8, 2034 TREATMENT OF SCHIZOPHRENIA
300MG ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Sept. 29, 2014 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10525057 March 8, 2034 TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
300MG/VIAL ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Feb. 28, 2013 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10525057 March 8, 2034 MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR 1 DISORDER
300MG/VIAL ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Feb. 28, 2013 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10525057 March 8, 2034 TREATMENT OF SCHIZOPHRENIA
300MG/VIAL ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Feb. 28, 2013 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10525057 March 8, 2034 TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
400MG ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Sept. 29, 2014 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10525057 March 8, 2034 MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR 1 DISORDER
400MG ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Sept. 29, 2014 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10525057 March 8, 2034 TREATMENT OF SCHIZOPHRENIA
400MG ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Sept. 29, 2014 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10525057 March 8, 2034 TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
400MG/VIAL ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Feb. 28, 2013 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10525057 March 8, 2034 MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR 1 DISORDER
400MG/VIAL ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Feb. 28, 2013 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10525057 March 8, 2034 TREATMENT OF SCHIZOPHRENIA
400MG/VIAL ABILIFY MAINTENA KIT OTSUKA PHARM CO LTD N202971 Feb. 28, 2013 RX FOR SUSPENSION, EXTENDED RELEASE INTRAMUSCULAR 10525057 March 8, 2034 TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 7.90 WOMBAT-PK CHEMBL
D(2) dopamine receptor GPCR PARTIAL AGONIST Ki 8.71 WOMBAT-PK CHEMBL
5-hydroxytryptamine receptor 1A GPCR PARTIAL AGONIST Ki 8.15 WOMBAT-PK DRUG LABEL
D(1A) dopamine receptor GPCR Ki 6.06 PDSP
Alpha-2A adrenergic receptor GPCR Ki 7.13 PDSP
Potassium voltage-gated channel subfamily H member 2 Ion channel Ki 6.22 CHEMBL
Multidrug resistance protein 1 Transporter IC50 6.11 CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 6.83 WOMBAT-PK
Sodium-dependent noradrenaline transporter Transporter Ki 5.68 PDSP
5-hydroxytryptamine receptor 2B GPCR Ki 9.44 PDSP
5-hydroxytryptamine receptor 2C GPCR Ki 7.36 WOMBAT-PK
5-hydroxytryptamine receptor 6 GPCR Ki 6.51 WOMBAT-PK
5-hydroxytryptamine receptor 7 GPCR Ki 7.69 WOMBAT-PK
Alpha-1A adrenergic receptor GPCR Ki 7.24 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 6.99 PDSP
D(3) dopamine receptor GPCR Ki 8.53 WOMBAT-PK
D(1B) dopamine receptor GPCR Ki 5.68 PDSP
Histamine H1 receptor GPCR Ki 7.22 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR Ki 5.17 PDSP
Muscarinic acetylcholine receptor M2 GPCR Ki 5.46 PDSP
Muscarinic acetylcholine receptor M3 GPCR Ki 5.33 PDSP
Muscarinic acetylcholine receptor M4 GPCR Ki 5.82 PDSP
Muscarinic acetylcholine receptor M5 GPCR Ki 5.63 PDSP
5-hydroxytryptamine receptor 1B GPCR Ki 6.10 WOMBAT-PK
5-hydroxytryptamine receptor 1D GPCR Ki 7.20 WOMBAT-PK
Alpha-2C adrenergic receptor GPCR Ki 7.42 PDSP
Sodium-dependent dopamine transporter Transporter Ki 5.49 PDSP
D(4) dopamine receptor GPCR Ki 6.65 WOMBAT-PK
Alpha-1B adrenergic receptor GPCR Ki 7.46 PDSP
5-hydroxytryptamine receptor 5A GPCR Ki 5.91 PDSP
5-hydroxytryptamine receptor 1E GPCR Ki 5.10 PDSP
Histamine H3 receptor GPCR Ki 5.63 CHEMBL
5-hydroxytryptamine receptor 3A Ion channel Ki 6.20 PDSP
Histone H1.0 Nuclear other Ki 7.55 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 6.85 PDSP
Beta-2 adrenergic receptor GPCR Ki 6.79 PDSP
Histamine H1 receptor GPCR Ki 7 CHEMBL
D(2) dopamine receptor GPCR Ki 9.10 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 9.40 CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 5.97 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 8.15 CHEMBL
5-hydroxytryptamine receptor 7 GPCR AGONIST Ki 7.80 IUPHAR
D(1A) dopamine receptor GPCR Ki 9.10 CHEMBL
D(3) dopamine receptor GPCR IC50 7.42 CHEMBL
D(4) dopamine receptor GPCR ANTAGONIST Ki 7.30 IUPHAR
5-hydroxytryptamine receptor 6 GPCR AGONIST Ki 6.80 IUPHAR
5-hydroxytryptamine receptor 2C GPCR IC50 7.59 CHEMBL

External reference:

IDSource
4021367 VUID
N0000148786 NUI
D01164 KEGG_DRUG
352393 RXNORM
C0299792 UMLSCUI
CHEBI:31236 CHEBI
9SC PDB_CHEM_ID
CHEMBL1112 ChEMBL_ID
D000068180 MESH_DESCRIPTOR_UI
DB01238 DRUGBANK_ID
34 IUPHAR_LIGAND_ID
7477 INN_ID
82VFR53I78 UNII
60795 PUBCHEM_CID
17034 MMSL
231328 MMSL
45384 MMSL
d04825 MMSL
4021367 VANDF
009852 NDDF
406784005 SNOMEDCT_US
406785006 SNOMEDCT_US
82VFR53I78 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Aripiprazole HUMAN PRESCRIPTION DRUG LABEL 1 0615-8375 TABLET 5 mg ORAL ANDA 32 sections
Aripiprazole HUMAN PRESCRIPTION DRUG LABEL 1 0615-8524 TABLET 2 mg ORAL ANDA 31 sections
Aripiprazole HUMAN PRESCRIPTION DRUG LABEL 1 0615-8525 TABLET 10 mg ORAL ANDA 31 sections
aripiprazole HUMAN PRESCRIPTION DRUG LABEL 1 0904-6656 TABLET 5 mg ORAL ANDA 30 sections
aripiprazole HUMAN PRESCRIPTION DRUG LABEL 1 0904-6656 TABLET 5 mg ORAL ANDA 30 sections
Aripiprazole HUMAN PRESCRIPTION DRUG LABEL 1 0904-7366 TABLET 2 mg ORAL ANDA 30 sections
Aripiprazole HUMAN PRESCRIPTION DRUG LABEL 1 0904-7367 TABLET 5 mg ORAL ANDA 30 sections
Aripiprazole HUMAN PRESCRIPTION DRUG LABEL 1 0904-7368 TABLET 10 mg ORAL ANDA 30 sections
Aripiprazole HUMAN PRESCRIPTION DRUG LABEL 1 0904-7369 TABLET 15 mg ORAL ANDA 30 sections
Aripiprazole HUMAN PRESCRIPTION DRUG LABEL 1 0904-7370 TABLET 20 mg ORAL ANDA 30 sections
Aripiprazole HUMAN PRESCRIPTION DRUG LABEL 1 0904-7371 TABLET 30 mg ORAL ANDA 30 sections
aripiprazole HUMAN PRESCRIPTION DRUG LABEL 1 13668-216 TABLET 2 mg ORAL ANDA 30 sections
aripiprazole HUMAN PRESCRIPTION DRUG LABEL 1 13668-217 TABLET 5 mg ORAL ANDA 30 sections
aripiprazole HUMAN PRESCRIPTION DRUG LABEL 1 13668-218 TABLET 10 mg ORAL ANDA 30 sections
aripiprazole HUMAN PRESCRIPTION DRUG LABEL 1 13668-219 TABLET 15 mg ORAL ANDA 30 sections
aripiprazole HUMAN PRESCRIPTION DRUG LABEL 1 13668-220 TABLET 20 mg ORAL ANDA 30 sections
aripiprazole HUMAN PRESCRIPTION DRUG LABEL 1 13668-221 TABLET 30 mg ORAL ANDA 30 sections
OPIPZA HUMAN PRESCRIPTION DRUG LABEL 1 15370-401 FILM, SOLUBLE 2 mg ORAL NDA 38 sections
OPIPZA HUMAN PRESCRIPTION DRUG LABEL 1 15370-402 FILM, SOLUBLE 5 mg ORAL NDA 38 sections
OPIPZA HUMAN PRESCRIPTION DRUG LABEL 1 15370-403 FILM, SOLUBLE 10 mg ORAL NDA 38 sections
ABILIFY HUMAN PRESCRIPTION DRUG LABEL 1 16590-323 TABLET 2 mg ORAL NDA 32 sections
ABILIFY HUMAN PRESCRIPTION DRUG LABEL 1 16590-745 TABLET 5 mg ORAL NDA 32 sections
Aripiprazole HUMAN PRESCRIPTION DRUG LABEL 1 16714-141 TABLET 2 mg ORAL ANDA 30 sections
Aripiprazole HUMAN PRESCRIPTION DRUG LABEL 1 16714-142 TABLET 5 mg ORAL ANDA 30 sections
Aripiprazole HUMAN PRESCRIPTION DRUG LABEL 1 16714-143 TABLET 10 mg ORAL ANDA 30 sections
Aripiprazole HUMAN PRESCRIPTION DRUG LABEL 1 16714-144 TABLET 15 mg ORAL ANDA 30 sections
Aripiprazole HUMAN PRESCRIPTION DRUG LABEL 1 16714-145 TABLET 20 mg ORAL ANDA 30 sections
Aripiprazole HUMAN PRESCRIPTION DRUG LABEL 1 16714-146 TABLET 30 mg ORAL ANDA 30 sections
ARIPIPRAZOLE HUMAN PRESCRIPTION DRUG LABEL 1 16729-278 TABLET 2 mg ORAL ANDA 31 sections
ARIPIPRAZOLE HUMAN PRESCRIPTION DRUG LABEL 1 16729-278 TABLET 2 mg ORAL ANDA 31 sections