Stem definition | Drug id | CAS RN |
---|---|---|
platelet aggregation inhibitors | 2423 | 125926-17-2 |
None
None
None
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Cardiac failure | 45.42 | 29.12 | 23 | 758 | 85821 | 53262464 |
Hepatic function abnormal | 42.35 | 29.12 | 17 | 764 | 36882 | 53311403 |
Platelet count decreased | 35.12 | 29.12 | 21 | 760 | 108078 | 53240207 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Peripheral arterial occlusive disease | 30.20 | 29.62 | 9 | 662 | 5700 | 32507155 |
Source | Code | Description |
---|---|---|
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D005343 | Fibrinolytic Agents |
MeSH PA | D006401 | Hematologic Agents |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D010975 | Platelet Aggregation Inhibitors |
MeSH PA | D018490 | Serotonin Agents |
MeSH PA | D012702 | Serotonin Antagonists |
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.41 | acidic |
pKa2 | 7.75 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 2A | GPCR | ANTAGONIST | Ki | 8.50 | IUPHAR | ||||
5-hydroxytryptamine receptor 2B | GPCR | ANTAGONIST | Ki | 6.60 | IUPHAR | ||||
5-hydroxytryptamine receptor 2C | GPCR | ANTAGONIST | Ki | 7.40 | IUPHAR | ||||
Serotonin 2 (5-HT2) receptor | GPCR | Ki | 7.75 | CHEMBL |
ID | Source |
---|---|
D01624 | KEGG_DRUG |
135159-51-2 | SECONDARY_CAS_RN |
C0286592 | UMLSCUI |
CHEBI:135697 | CHEBI |
CHEMBL541829 | ChEMBL_ID |
CHEMBL52939 | ChEMBL_ID |
DB12163 | DRUGBANK_ID |
C064294 | MESH_SUPPLEMENTAL_RECORD_UI |
5160 | PUBCHEM_CID |
210 | IUPHAR_LIGAND_ID |
6611 | INN_ID |
19P708E787 | UNII |
None