DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
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L1000
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
sarpogrelate 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
platelet aggregation inhibitors
2423
125926-17-2
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
anplag
MCI-9042
sarpogrelate
sarpogrelate hydrochloride
sarpogrelate HCl
Molecular weight: 429.51
Formula: C24H31NO6
CLOGP: 2.04
LIPINSKI: 0
HAC: 7
HDO: 1
TPSA: 85.30
ALOGS: -4.60
ROTB: 14
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Interstitial lung disease
45.56
31.05
22
747
112578
79631041
Hepatic function abnormal
37.99
31.05
17
752
73090
79670529
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
MeSH PA
D002317
Cardiovascular Agents
MeSH PA
D005343
Fibrinolytic Agents
MeSH PA
D006401
Hematologic Agents
MeSH PA
D018377
Neurotransmitter Agents
MeSH PA
D010975
Platelet Aggregation Inhibitors
MeSH PA
D018490
Serotonin Agents
MeSH PA
D012702
Serotonin Antagonists
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
4.41
acidic
pKa2
7.75
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
5-hydroxytryptamine receptor 2A
GPCR
P28223
5HT2A_HUMAN
ANTAGONIST
Ki
8.50
IUPHAR
5-hydroxytryptamine receptor 2B
GPCR
P41595
5HT2B_HUMAN
ANTAGONIST
Ki
6.60
IUPHAR
5-hydroxytryptamine receptor 2C
GPCR
P28335
5HT2C_HUMAN
ANTAGONIST
Ki
7.40
IUPHAR
Serotonin 2 (5-HT2) receptor
GPCR
5HT2C_RAT
5HT2A_RAT
5HT2B_RAT
Ki
7.75
CHEMBL
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External reference:
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ID
Source
135159-51-2
SECONDARY_CAS_RN
19P708E787
UNII
210
IUPHAR_LIGAND_ID
5160
PUBCHEM_CID
6611
INN_ID
C0286592
UMLSCUI
C064294
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:135697
CHEBI
CHEMBL52939
ChEMBL_ID
CHEMBL541829
ChEMBL_ID
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Pharmaceutical products:
None
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sarpogrelate