sarpogrelate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| platelet aggregation inhibitors | 2423 | 125926-17-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Cardiac failure | 45.42 | 29.12 | 23 | 758 | 85821 | 53262464 |
| Hepatic function abnormal | 42.35 | 29.12 | 17 | 764 | 36882 | 53311403 |
| Platelet count decreased | 35.12 | 29.12 | 21 | 760 | 108078 | 53240207 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Peripheral arterial occlusive disease | 30.20 | 29.62 | 9 | 662 | 5700 | 32507155 |
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D005343 | Fibrinolytic Agents |
| MeSH PA | D006401 | Hematologic Agents |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D010975 | Platelet Aggregation Inhibitors |
| MeSH PA | D018490 | Serotonin Agents |
| MeSH PA | D012702 | Serotonin Antagonists |
Drug Use (View source of the data)
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.41 | acidic |
| pKa2 | 7.75 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2A | GPCR | ANTAGONIST | Ki | 8.50 | IUPHAR | ||||
| 5-hydroxytryptamine receptor 2B | GPCR | ANTAGONIST | Ki | 6.60 | IUPHAR | ||||
| 5-hydroxytryptamine receptor 2C | GPCR | ANTAGONIST | Ki | 7.40 | IUPHAR | ||||
| Serotonin 2 (5-HT2) receptor | GPCR | Ki | 7.75 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D01624 | KEGG_DRUG |
| 135159-51-2 | SECONDARY_CAS_RN |
| C0286592 | UMLSCUI |
| CHEBI:135697 | CHEBI |
| CHEMBL541829 | ChEMBL_ID |
| CHEMBL52939 | ChEMBL_ID |
| DB12163 | DRUGBANK_ID |
| C064294 | MESH_SUPPLEMENTAL_RECORD_UI |
| 5160 | PUBCHEM_CID |
| 210 | IUPHAR_LIGAND_ID |
| 6611 | INN_ID |
| 19P708E787 | UNII |
Pharmaceutical products:
None