sarpogrelate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
platelet aggregation inhibitors 2423 125926-17-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • anplag
  • MCI-9042
  • sarpogrelate
  • sarpogrelate hydrochloride
  • sarpogrelate HCl
  • Molecular weight: 429.51
  • Formula: C24H31NO6
  • CLOGP: 2.04
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 85.30
  • ALOGS: -4.60
  • ROTB: 14

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiac failure 45.42 29.12 23 758 85821 53262464
Hepatic function abnormal 42.35 29.12 17 764 36882 53311403
Platelet count decreased 35.12 29.12 21 760 108078 53240207

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Peripheral arterial occlusive disease 30.20 29.62 9 662 5700 32507155

Pharmacologic Action:

SourceCodeDescription
MeSH PA D002317 Cardiovascular Agents
MeSH PA D005343 Fibrinolytic Agents
MeSH PA D006401 Hematologic Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D010975 Platelet Aggregation Inhibitors
MeSH PA D018490 Serotonin Agents
MeSH PA D012702 Serotonin Antagonists

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.41 acidic
pKa2 7.75 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 8.50 IUPHAR
5-hydroxytryptamine receptor 2B GPCR ANTAGONIST Ki 6.60 IUPHAR
5-hydroxytryptamine receptor 2C GPCR ANTAGONIST Ki 7.40 IUPHAR
Serotonin 2 (5-HT2) receptor GPCR Ki 7.75 CHEMBL

External reference:

IDSource
D01624 KEGG_DRUG
135159-51-2 SECONDARY_CAS_RN
C0286592 UMLSCUI
CHEBI:135697 CHEBI
CHEMBL541829 ChEMBL_ID
CHEMBL52939 ChEMBL_ID
DB12163 DRUGBANK_ID
C064294 MESH_SUPPLEMENTAL_RECORD_UI
5160 PUBCHEM_CID
210 IUPHAR_LIGAND_ID
6611 INN_ID
19P708E787 UNII

Pharmaceutical products:

None