sarpogrelate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
platelet aggregation inhibitors	2423	125926-17-2

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

anplag
MCI-9042
sarpogrelate
sarpogrelate hydrochloride
sarpogrelate HCl

Molecular weight: 429.51
Formula: C24H31NO6
CLOGP: 2.04
LIPINSKI: 0
HAC: 7
HDO: 1
TPSA: 85.30
ALOGS: -4.60
ROTB: 14

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hepatic function abnormal	38.29	32.40	17	678	64296	64433741
Interstitial lung disease	34.36	32.40	18	677	97714	64400323

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D005343	Fibrinolytic Agents
MeSH PA	D006401	Hematologic Agents
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D010975	Platelet Aggregation Inhibitors
MeSH PA	D018490	Serotonin Agents
MeSH PA	D012702	Serotonin Antagonists

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.41	acidic
pKa2	7.75	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN	ANTAGONIST	Ki	8.50		IUPHAR
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN	ANTAGONIST	Ki	6.60		IUPHAR
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN	ANTAGONIST	Ki	7.40		IUPHAR
Serotonin 2 (5-HT2) receptor	GPCR		5HT2C_RAT 5HT2A_RAT 5HT2B_RAT		Ki	7.75		CHEMBL

External reference:

ID	Source
D01624	KEGG_DRUG
C0286592	UMLSCUI
CHEBI:135697	CHEBI
CHEMBL541829	ChEMBL_ID
CHEMBL52939	ChEMBL_ID
DB12163	DRUGBANK_ID
C064294	MESH_SUPPLEMENTAL_RECORD_UI
5160	PUBCHEM_CID
210	IUPHAR_LIGAND_ID
6611	INN_ID
135159-51-2	SECONDARY_CAS_RN
19P708E787	UNII

Pharmaceutical products:

None