salicylic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
analgesic anti-inflammatory 2416 69-72-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • choline salicylate
  • choline subsalicylate
  • salicylic acid
  • 2-Carboxyphenol
  • 2-Hydroxybenzenecarboxylic acid
  • 2-Hydroxybenzoic acid
  • imidazole salicylate
  • sodium salicylate
  • morpholine salicylate
  • potassium salicylate
A compound obtained from the bark of the white willow and wintergreen leaves. It has bacteriostatic, fungicidal, and keratolytic actions.
  • Molecular weight: 138.12
  • Formula: C7H6O3
  • CLOGP: 2.19
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 57.53
  • ALOGS: -1.09
  • ROTB: 1

Drug dosage:

DoseUnitRoute
3 g O
3 g O
7 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 2.51 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 15 % Benet LZ, Broccatelli F, Oprea TI
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1898 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 704.54 16.45 216 7936 24160 63456710
Completed suicide 311.52 16.45 207 7945 145466 63335404
Chronic sinusitis 209.46 16.45 74 8078 12769 63468101
Paraesthesia oral 183.72 16.45 75 8077 19181 63461689
Procedural pain 175.50 16.45 75 8077 21494 63459376
Toxicity to various agents 126.68 16.45 157 7995 247093 63233777
Erythema 122.69 16.45 131 8021 175620 63305250
Therapeutic product effect incomplete 118.28 16.45 110 8042 124946 63355924
Vaginal flatulence 111.28 16.45 33 8119 3260 63477610
Skin burning sensation 105.93 16.45 45 8107 12689 63468181
Proctitis 94.98 16.45 33 8119 5408 63475462
Female genital tract fistula 87.95 16.45 34 8118 7525 63473345
Drug ineffective 81.50 16.45 305 7847 1044460 62436410
Radiculopathy 80.24 16.45 33 8119 8578 63472292
Vaginal discharge 78.14 16.45 33 8119 9165 63471705
Dyspepsia 78.02 16.45 80 8072 102116 63378754
Broncholithiasis 77.07 16.45 15 8137 238 63480632
Skin irritation 76.31 16.45 33 8119 9708 63471162
Lymph node calcification 73.01 16.45 15 8137 317 63480553
Skin exfoliation 65.71 16.45 50 8102 43052 63437818
Frequent bowel movements 62.07 16.45 38 8114 22984 63457886
Colitis ulcerative 60.16 16.45 39 8113 26052 63454818
Dry skin 57.49 16.45 52 8100 56835 63424035
Oral candidiasis 54.84 16.45 35 8117 22763 63458107
Bronchial wall thickening 50.54 16.45 15 8137 1484 63479386
Pain of skin 44.17 16.45 24 8128 11610 63469260
Drug hypersensitivity 42.80 16.45 111 8041 310576 63170294
Lower respiratory tract infection viral 38.99 16.45 11 8141 910 63479960
Lichen nitidus 37.56 16.45 7 8145 87 63480783
Exposure via ingestion 37.12 16.45 14 8138 2895 63477975
Colitis 37.00 16.45 38 8114 48490 63432380
Suspected suicide 34.92 16.45 17 8135 6551 63474319
Weight decreased 34.16 16.45 95 8057 276703 63204167
Rectal haemorrhage 33.12 16.45 36 8116 48994 63431876
Haematochezia 28.88 16.45 35 8117 53509 63427361
Chemical burn of skin 27.64 16.45 5 8147 52 63480818
Skin swelling 24.76 16.45 11 8141 3448 63477422
Infusion related reaction 24.32 16.45 78 8074 245443 63235427
Malaise 23.82 16.45 111 8041 415843 63065027
Obstructive airways disorder 23.04 16.45 20 8132 20679 63460191
Dysaesthesia 22.05 16.45 11 8141 4467 63476403
Sexual abuse 20.82 16.45 5 8147 219 63480651
Soft tissue necrosis 20.34 16.45 6 8146 581 63480289
Pyrexia 20.28 16.45 116 8036 470362 63010508
Nausea 19.64 16.45 181 7971 854290 62626580
Jarisch-Herxheimer reaction 18.24 16.45 5 8147 372 63480498
Drug intolerance 17.35 16.45 9 8143 308652 63172218
Systemic lupus erythematosus 17.29 16.45 3 8149 208915 63271955
Skin hyperpigmentation 16.53 16.45 10 8142 5911 63474959

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 290.02 17.90 172 4399 97996 34854364
Toxicity to various agents 85.20 17.90 117 4454 200245 34752115
Anal inflammation 75.57 17.90 20 4551 1280 34951080
SARS-CoV-2 test negative 65.58 17.90 17 4554 1003 34951357
Choroiditis 62.63 17.90 17 4554 1198 34951162
Skin burning sensation 54.07 17.90 21 4550 4622 34947738
Accident 52.37 17.90 21 4550 5026 34947334
Endophthalmitis 52.25 17.90 19 4552 3489 34948871
Proctalgia 46.50 17.90 20 4551 5703 34946657
Intraocular pressure increased 34.71 17.90 16 4555 5367 34946993
Dry skin 33.94 17.90 30 4541 31257 34921103
Erythema 31.89 17.90 48 4523 88732 34863628
Visual acuity reduced 31.71 17.90 22 4549 16127 34936233
Haemorrhoids 31.34 17.90 21 4550 14554 34937806
Body temperature increased 28.02 17.90 21 4550 17347 34935013
Eye pain 27.99 17.90 19 4552 13443 34938917
Chondritis 27.62 17.90 6 4565 164 34952196
Skin exfoliation 25.25 17.90 24 4547 27408 34924952
Appendicolith 25.00 17.90 15 4556 8586 34943774
Palmar-plantar erythrodysaesthesia syndrome 24.22 17.90 19 4552 16776 34935584
Suspected suicide 24.17 17.90 12 4559 4736 34947624
Exposure via ingestion 22.36 17.90 9 4562 2172 34950188
Appendicitis 21.89 17.90 17 4554 14790 34937570
Psoriasis 21.60 17.90 26 4545 38786 34913574
Condition aggravated 21.12 17.90 64 4507 192132 34760228
Post inflammatory pigmentation change 19.33 17.90 5 4566 292 34952068

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 559.43 14.90 380 11209 245387 79487412
Macular degeneration 202.09 14.90 72 11517 11224 79721575
Chronic sinusitis 192.08 14.90 72 11517 12954 79719845
Toxicity to various agents 190.65 14.90 268 11321 421272 79311527
Paraesthesia oral 160.60 14.90 72 11517 20399 79712400
Procedural pain 155.41 14.90 73 11516 23011 79709788
Skin burning sensation 144.89 14.90 59 11530 13213 79719586
Erythema 130.04 14.90 161 11428 223129 79509670
Vaginal flatulence 110.77 14.90 32 11557 2543 79730256
Therapeutic product effect incomplete 90.27 14.90 107 11482 141538 79591261
Female genital tract fistula 87.96 14.90 33 11556 5942 79726857
Skin irritation 86.44 14.90 39 11550 11201 79721598
Dry skin 83.04 14.90 73 11516 67922 79664877
Proctitis 82.04 14.90 32 11557 6400 79726399
Skin exfoliation 81.37 14.90 66 11523 55034 79677765
Vaginal discharge 77.43 14.90 32 11557 7431 79725368
Radiculopathy 75.50 14.90 33 11556 8791 79724008
Broncholithiasis 69.86 14.90 14 11575 228 79732571
Anal inflammation 67.02 14.90 19 11570 1411 79731388
Dyspepsia 64.14 14.90 79 11510 108608 79624191
Lymph node calcification 62.33 14.90 14 11575 401 79732398
Exposure via ingestion 56.45 14.90 23 11566 5151 79727648
SARS-CoV-2 test negative 54.38 14.90 16 11573 1355 79731444
Choroiditis 54.27 14.90 16 11573 1365 79731434
Suspected suicide 51.95 14.90 27 11562 10549 79722250
Frequent bowel movements 49.21 14.90 38 11551 29501 79703298
Pain of skin 46.37 14.90 28 11561 14585 79718214
Colitis ulcerative 45.83 14.90 39 11550 34703 79698096
Oral candidiasis 42.69 14.90 35 11554 29593 79703206
Bronchial wall thickening 36.75 14.90 14 11575 2627 79730172
Proctalgia 36.55 14.90 21 11568 9980 79722819
Lichen nitidus 36.47 14.90 7 11582 90 79732709
Accident 36.22 14.90 20 11569 8811 79723988
Endophthalmitis 36.20 14.90 18 11571 6410 79726389
Chemical burn of skin 34.64 14.90 7 11582 119 79732680
Palmar-plantar erythrodysaesthesia syndrome 31.57 14.90 31 11558 33103 79699696
Lower respiratory tract infection viral 30.51 14.90 10 11579 1210 79731589
Malaise 29.58 14.90 145 11444 489724 79243075
Drug hypersensitivity 29.52 14.90 103 11486 298813 79433986
Soft tissue necrosis 29.07 14.90 9 11580 906 79731893
Psoriasis 27.70 14.90 48 11541 89539 79643260
Weight decreased 27.32 14.90 113 11476 355085 79377714
Rectal haemorrhage 25.06 14.90 42 11547 76258 79656541
Skin swelling 24.88 14.90 12 11577 4002 79728797
Appendicolith 23.61 14.90 15 11574 8536 79724263
Intraocular pressure increased 22.60 14.90 15 11574 9190 79723609
Pyrexia 21.95 14.90 171 11418 678538 79054261
Chondritis 21.73 14.90 5 11584 160 79732639
Infusion related reaction 21.56 14.90 78 11511 230159 79502640
Colitis 21.01 14.90 38 11551 73269 79659530
Scab 18.48 14.90 14 11575 10558 79722241
Visual acuity reduced 18.30 14.90 22 11567 29447 79703352
Appendicitis 17.15 14.90 18 11571 20776 79712023
Dermatitis 16.78 14.90 18 11571 21303 79711496
Post inflammatory pigmentation change 16.52 14.90 5 11584 467 79732332
Sensitive skin 16.32 14.90 7 11582 1780 79731019
Haematochezia 16.30 14.90 38 11551 87607 79645192
Poisoning 15.91 14.90 19 11570 25253 79707546
Skin atrophy 15.71 14.90 10 11579 5708 79727091
Eye pain 15.55 14.90 23 11566 37555 79695244
Dysaesthesia 15.51 14.90 10 11579 5838 79726961
Haemorrhoids 15.30 14.90 20 11569 29108 79703691
Anal erosion 14.90 14.90 3 11586 50 79732749

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D01AE12 DERMATOLOGICALS
ANTIFUNGALS FOR DERMATOLOGICAL USE
ANTIFUNGALS FOR TOPICAL USE
Other antifungals for topical use
ATC N02BA03 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
ATC N02BA04 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
ATC N02BA08 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
ATC N02BA12 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
ATC N02BA16 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
ATC S01BC08 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Antiinflammatory agents, non-steroids
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D016861 Cyclooxygenase Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35441 antiinfective agents
CHEBI has role CHEBI:35718 antifungal agents
CHEBI has role CHEBI:37848 plant hormones
CHEBI has role CHEBI:50176 keratolytic drugs
CHEBI has role CHEBI:73181 ascorbate peroxidase inhibitor
CHEBI has role CHEBI:76924 plant metabolites
CHEBI has role CHEBI:84735 algal metabolites
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents
MeSH PA D003879 Dermatologic Agents
MeSH PA D007641 Keratolytic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Tinea pedis indication 6020002 DOID:12403
Pain indication 22253000
Greasy skin indication 42273000
Seborrheic dermatitis indication 50563003 DOID:8741
Allergic rhinitis indication 61582004
Verruca plantaris indication 63440008 DOID:13775
Rheumatoid arthritis indication 69896004 DOID:7148
Common cold indication 82272006 DOID:10459
Tinea corporis indication 84849002
Acne vulgaris indication 88616000
Pityriasis simplex indication 200767005
Disorder of keratinization indication 277905003
Fever indication 386661006
Hyperkeratosis indication 396228006
Osteoarthritis indication 396275006
Synovitis indication 416209007 DOID:2703
Calluses and Corns indication
Crohn's disease off-label use 34000006
Tendinitis off-label use 34840004 DOID:971
Rheumatic fever off-label use 58718002 DOID:1586
Ulcerative colitis off-label use 64766004 DOID:8577
Tenosynovitis off-label use 67801009 DOID:970
Juvenile rheumatoid arthritis off-label use 410795001
Itching of skin off-label use 418363000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.81 acidic
pKa2 12.79 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Carbonic anhydrase 2 Enzyme Ki 5.15 CHEMBL
Carbonic anhydrase 1 Enzyme Ki 5 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 4.95 CHEMBL
Carbonic anhydrase 9 Enzyme Ki 4.10 CHEMBL
Carbonic anhydrase 12 Enzyme Ki 5.06 CHEMBL
Carbonic anhydrase 7 Enzyme Ki 4.09 CHEMBL
Carbonic anhydrase 6 Enzyme Ki 4.92 CHEMBL
Carbonic anhydrase 14 Enzyme Ki 4.30 CHEMBL
High mobility group protein B1 Nuclear other Kd 6 CHEMBL
Nicotinate phosphoribosyltransferase Enzyme Ki 9.80 CHEMBL
Salicylic acid-binding protein 2 Enzyme WOMBAT-PK
Carbonic anhydrase 13 Enzyme Ki 4.17 CHEMBL
Polyphenol oxidase 2 Enzyme IC50 4 CHEMBL
Carbonic anhydrase 15 Enzyme Ki 5.14 CHEMBL
Solute carrier family 22 member 20 Transporter Ki 4.36 CHEMBL

External reference:

IDSource
4018663 VUID
N0000146974 NUI
D00097 KEGG_DRUG
2016-36-6 SECONDARY_CAS_RN
36364-49-5 SECONDARY_CAS_RN
54-21-7 SECONDARY_CAS_RN
147-90-0 SECONDARY_CAS_RN
578-36-9 SECONDARY_CAS_RN
4018419 VANDF
4018434 VANDF
4018663 VANDF
4018996 VANDF
C0036079 UMLSCUI
CHEBI:16914 CHEBI
SAL PDB_CHEM_ID
CHEMBL424 ChEMBL_ID
DB00936 DRUGBANK_ID
CHEMBL2104095 ChEMBL_ID
CHEMBL2104788 ChEMBL_ID
CHEMBL447868 ChEMBL_ID
D020156 MESH_DESCRIPTOR_UI
338 PUBCHEM_CID
C015075 MESH_SUPPLEMENTAL_RECORD_UI
4306 IUPHAR_LIGAND_ID
O414PZ4LPZ UNII
DB14006 DRUGBANK_ID
DB13860 DRUGBANK_ID
20974 RXNORM
4438 MMSL
5235 MMSL
5439 MMSL
5494 MMSL
9170 MMSL
d00492 MMSL
d00843 MMSL
001586 NDDF
001590 NDDF
001592 NDDF
001951 NDDF
005692 NDDF
006027 NDDF
370179008 SNOMEDCT_US
387253001 SNOMEDCT_US
387411000 SNOMEDCT_US
46741005 SNOMEDCT_US
65302009 SNOMEDCT_US
72968006 SNOMEDCT_US
D012980 MESH_DESCRIPTOR_UI
CHEMBL3707214 ChEMBL_ID
CHEMBL3707342 ChEMBL_ID
1938 INN_ID
5485 INN_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
SKIN MEDICA Purifying Foaming Wash HUMAN OTC DRUG LABEL 1 0023-4948 LIQUID 20 mg TOPICAL OTC monograph final 10 sections
SKIN MEDICA Purifying Foaming Wash HUMAN OTC DRUG LABEL 1 0023-4948 LIQUID 20 mg TOPICAL OTC monograph final 10 sections
DHS SAL4 oz. HUMAN OTC DRUG LABEL 1 0096-0738 SHAMPOO 0.04 g TOPICAL OTC monograph final 8 sections
Zapzyt Acne Wash Cleanser HUMAN OTC DRUG LABEL 1 0295-0071 GEL 2 g TOPICAL OTC monograph final 9 sections
Zapzyt Acne Wash Cleanser HUMAN OTC DRUG LABEL 1 0295-9055 GEL 2 g TOPICAL OTC monograph final 10 sections
Cetaphil Gentle Clear Mattifying Acne Moisturizer HUMAN OTC DRUG LABEL 1 0299-4117 LOTION 5 mg TOPICAL OTC monograph final 9 sections
Cetaphil Gentle Clear Mattifying Acne Moisturizer HUMAN OTC DRUG LABEL 1 0299-4117 LOTION 5 mg TOPICAL OTC monograph final 9 sections
Cetaphil Gentle Clear Clarifying Acne Cleanser HUMAN OTC DRUG LABEL 1 0299-4119 CREAM 20 mg TOPICAL OTC monograph final 10 sections
Cetaphil Gentle Clear Clarifying Acne Cleanser HUMAN OTC DRUG LABEL 1 0299-4119 CREAM 20 mg TOPICAL OTC monograph final 10 sections
Cetaphil Acne Relief Body Wash HUMAN OTC DRUG LABEL 1 0299-4121 GEL 20 mg TOPICAL OTC monograph final 10 sections
Cetaphil Acne Relief Body Wash HUMAN OTC DRUG LABEL 1 0299-4121 GEL 20 mg TOPICAL OTC monograph final 10 sections
Differin Acne Clearing Body Wash HUMAN OTC DRUG LABEL 1 0299-4131 GEL 20 mg TOPICAL OTC monograph final 11 sections
Differin Acne Clearing Body HUMAN OTC DRUG LABEL 1 0299-4132 AEROSOL, SPRAY 2 g TOPICAL OTC monograph final 11 sections
Cetaphil Gentle Clear Triple-Action Acne Serum HUMAN OTC DRUG LABEL 1 0299-4135 SOLUTION 5 mg TOPICAL OTC monograph final 9 sections
Differin Acne Clearing Body Scrub HUMAN OTC DRUG LABEL 1 0299-4609 LIQUID 20 mg TOPICAL OTC monograph final 10 sections
Differin Acne Clearing Body Scrub HUMAN OTC DRUG LABEL 1 0299-4609 LIQUID 20 mg TOPICAL OTC monograph final 10 sections
Almay Clear Complexion Liquid Makeup for Oily Skin HUMAN OTC DRUG LABEL 1 0311-0715 LIQUID 0.50 mg TOPICAL OTC monograph final 7 sections
Almay Clear Complexion Blemish Healing Spot Concealer HUMAN OTC DRUG LABEL 1 0311-0716 LIQUID 2 mg TOPICAL OTC monograph final 8 sections
Almay Clear Complexion Blemish Healing Spot Concealer HUMAN OTC DRUG LABEL 1 0311-0718 LIQUID 0.01 g TOPICAL OTC monograph final 8 sections
Almay Clear Complexion Liquid Makeup HUMAN OTC DRUG LABEL 1 0311-0720 LIQUID 2 mg TOPICAL OTC monograph final 8 sections
Almay Clear Complexion Pressed Powder HUMAN OTC DRUG LABEL 1 0311-0721 POWDER 0.00 g TOPICAL OTC monograph final 8 sections
Almay Clear Complexion Blemish Armor HUMAN OTC DRUG LABEL 1 0311-0722 LIQUID 2 mg TOPICAL OTC monograph final 10 sections
ALMAY CLEAR COMPLEXION MAKEUP HUMAN OTC DRUG LABEL 1 0311-0724 EMULSION 1 mg TOPICAL OTC monograph final 7 sections
ALMAY CLEAR COMPLEXION CONCEALER HUMAN OTC DRUG LABEL 1 0311-0725 LIQUID 2 mg TOPICAL OTC monograph final 8 sections
PanOxyl Clarifying Exfoliant HUMAN OTC DRUG LABEL 1 0316-0296 LIQUID 2 g TOPICAL OTC monograph final 12 sections
Salicylic acid HUMAN OTC DRUG LABEL 1 0363-0017 CREAM 5.05 mg TOPICAL OTC monograph final 10 sections
Salicylic acid HUMAN OTC DRUG LABEL 1 0363-0017 CREAM 5.05 mg TOPICAL OTC monograph final 10 sections
Charcoal Blackhead Clearing Scrub HUMAN OTC DRUG LABEL 1 0363-0027 CREAM 20.60 mg TOPICAL OTC monograph final 11 sections
Charcoal Blackhead Clearing Scrub HUMAN OTC DRUG LABEL 1 0363-0027 CREAM 20.60 mg TOPICAL OTC monograph final 11 sections
Salicylic Acid HUMAN OTC DRUG LABEL 1 0363-0203 PATCH 40 mg TOPICAL OTC monograph final 12 sections