salicylic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
analgesic anti-inflammatory 2416 69-72-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • choline salicylate
  • choline subsalicylate
  • salicylic acid
  • 2-Carboxyphenol
  • 2-Hydroxybenzenecarboxylic acid
  • 2-Hydroxybenzoic acid
  • imidazole salicylate
  • sodium salicylate
  • morpholine salicylate
  • potassium salicylate
A compound obtained from the bark of the white willow and wintergreen leaves. It has bacteriostatic, fungicidal, and keratolytic actions.
  • Molecular weight: 138.12
  • Formula: C7H6O3
  • CLOGP: 2.19
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 57.53
  • ALOGS: -1.09
  • ROTB: 1

Drug dosage:

DoseUnitRoute
3 g O
3 g O
7 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 2.51 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 15 % Benet LZ, Broccatelli F, Oprea TI
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1898 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 399.12 18.53 197 4127 133636 56154107
Toxicity to various agents 185.02 18.53 146 4178 224418 56063325
Skin burning sensation 134.83 18.53 45 4279 10986 56276757
Erythema 116.60 18.53 96 4228 155843 56131900
Acne 103.01 18.53 44 4280 21092 56266651
Skin irritation 93.48 18.53 32 4292 8423 56279320
Dry skin 90.48 18.53 52 4272 47057 56240686
Broncholithiasis 86.67 18.53 15 4309 208 56287535
Skin exfoliation 82.46 18.53 45 4279 36855 56250888
Lymph node calcification 82.28 18.53 15 4309 284 56287459
Drug hypersensitivity 78.85 18.53 101 4223 275104 56012639
Bronchial wall thickening 63.07 18.53 15 4309 1065 56286678
Pain of skin 62.82 18.53 24 4300 8622 56279121
Exposure via ingestion 44.66 18.53 14 4310 2794 56284949
Lichen nitidus 42.28 18.53 7 4317 73 56287670
Suspected suicide 39.08 18.53 15 4309 5451 56282292
Skin swelling 33.54 18.53 11 4313 2535 56285208
Lower respiratory tract infection viral 30.76 18.53 8 4316 819 56286924
Obstructive airways disorder 30.29 18.53 18 4306 17264 56270479
Chemical burn of skin 30.21 18.53 5 4319 52 56287691
Soft tissue necrosis 24.98 18.53 6 4318 444 56287299
Sexual abuse 23.68 18.53 5 4319 206 56287537
Psoriasis 23.28 18.53 32 4292 92660 56195083
Skin hyperpigmentation 22.26 18.53 10 4314 5387 56282356
Nasal congestion 21.48 18.53 24 4300 56346 56231397
Palmoplantar keratoderma 20.44 18.53 4 4320 112 56287631
Therapeutic product effect incomplete 20.00 18.53 32 4292 105999 56181744
Productive cough 19.83 18.53 23 4301 56209 56231534

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 296.25 21.48 153 2894 91361 31602936
Toxicity to various agents 96.76 21.48 102 2945 181385 31512912
Choroiditis 64.00 21.48 16 3031 1116 31693181
Skin burning sensation 63.78 21.48 21 3026 3918 31690379
Acne 53.90 21.48 24 3023 10136 31684161
Endophthalmitis 53.45 21.48 18 3029 3598 31690699
Erythema 44.02 21.48 46 3001 80359 31613938
Dry skin 37.96 21.48 26 3021 25455 31668842
Intraocular pressure increased 36.59 21.48 15 3032 5172 31689125
Uveitis 35.82 21.48 16 3031 6800 31687497
Appendicolith 35.15 21.48 15 3032 5716 31688581
Visual acuity reduced 33.67 21.48 20 3027 15323 31678974
Palmar-plantar erythrodysaesthesia syndrome 30.93 21.48 19 3028 15464 31678833
Appendicitis 30.66 21.48 17 3030 11448 31682849
Chondritis 30.01 21.48 6 3041 149 31694148
Psoriasis 29.68 21.48 29 3018 46690 31647607
Eye pain 29.54 21.48 17 3030 12287 31682010
Condition aggravated 27.26 21.48 53 2994 163956 31530341
Exposure via ingestion 25.71 21.48 9 3038 2016 31692281
Skin exfoliation 23.50 21.48 19 3028 23855 31670442
Suspected suicide 22.73 21.48 10 3037 4097 31690200
Post inflammatory pigmentation change 21.64 21.48 5 3042 249 31694048

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 647.84 18.06 351 6588 226784 70694721
Toxicity to various agents 256.12 18.06 245 6694 381927 70539578
Skin burning sensation 176.36 18.06 59 6880 11367 70910138
Acne 131.51 18.06 59 6880 24930 70896575
Erythema 129.30 18.06 126 6813 199437 70722068
Dry skin 116.76 18.06 71 6868 55860 70865645
Skin irritation 102.48 18.06 38 6901 9871 70911634
Skin exfoliation 92.01 18.06 58 6881 48568 70872937
Broncholithiasis 77.11 18.06 14 6925 200 70921305
Lymph node calcification 69.01 18.06 14 6925 368 70921137
Exposure via ingestion 66.48 18.06 23 6916 4892 70916613
Pain of skin 59.65 18.06 26 6913 10240 70911265
Choroiditis 56.69 18.06 15 6924 1286 70920219
Drug hypersensitivity 54 18.06 94 6845 262365 70659140
Suspected suicide 53.37 18.06 23 6916 8811 70912694
Psoriasis 47.15 18.06 53 6886 98380 70823125
Palmar-plantar erythrodysaesthesia syndrome 44.84 18.06 31 6908 30216 70891289
Bronchial wall thickening 44.81 18.06 14 6925 2165 70919340
Lichen nitidus 40.33 18.06 7 6932 76 70921429
Endophthalmitis 40.15 18.06 17 6922 6238 70915267
Chemical burn of skin 37.64 18.06 7 6932 115 70921390
Appendicolith 35.01 18.06 15 6924 5665 70915840
Soft tissue necrosis 34.07 18.06 9 6930 766 70920739
Skin swelling 32.33 18.06 12 6927 3119 70918386
Appendicitis 26.81 18.06 18 6921 16715 70904790
Intraocular pressure increased 25.77 18.06 14 6925 8887 70912618
Poisoning 24.08 18.06 19 6920 22603 70898902
Chondritis 23.94 18.06 5 6934 152 70921353
Visual acuity reduced 22.57 18.06 20 6919 27910 70893595
Lower respiratory tract infection viral 22.32 18.06 7 6932 1095 70920410
Uveitis 21.49 18.06 15 6924 14830 70906675
Sensitive skin 21.15 18.06 7 6932 1300 70920205
Dermatitis 20.01 18.06 16 6923 19401 70902104
Eye pain 19.17 18.06 20 6919 34082 70887423
Post inflammatory pigmentation change 19.09 18.06 5 6934 412 70921093
Palmoplantar keratoderma 18.72 18.06 5 6934 444 70921061

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D01AE12 DERMATOLOGICALS
ANTIFUNGALS FOR DERMATOLOGICAL USE
ANTIFUNGALS FOR TOPICAL USE
Other antifungals for topical use
ATC N02BA03 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
ATC N02BA04 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
ATC N02BA08 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
ATC N02BA12 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
ATC N02BA16 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
ATC S01BC08 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Antiinflammatory agents, non-steroids
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D016861 Cyclooxygenase Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35441 antiinfective agents
CHEBI has role CHEBI:35718 antifungal agents
CHEBI has role CHEBI:37848 plant hormones
CHEBI has role CHEBI:50176 keratolytic drugs
CHEBI has role CHEBI:73181 ascorbate peroxidase inhibitor
CHEBI has role CHEBI:76924 plant metabolites
CHEBI has role CHEBI:84735 algal metabolites
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents
MeSH PA D003879 Dermatologic Agents
MeSH PA D007641 Keratolytic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Tinea pedis indication 6020002 DOID:12403
Pain indication 22253000
Greasy skin indication 42273000
Seborrheic dermatitis indication 50563003 DOID:8741
Allergic rhinitis indication 61582004
Verruca plantaris indication 63440008 DOID:13775
Rheumatoid arthritis indication 69896004 DOID:7148
Common cold indication 82272006 DOID:10459
Tinea corporis indication 84849002
Acne vulgaris indication 88616000
Pityriasis simplex indication 200767005
Disorder of keratinization indication 277905003
Fever indication 386661006
Hyperkeratosis indication 396228006
Osteoarthritis indication 396275006
Synovitis indication 416209007 DOID:2703
Calluses and Corns indication
Crohn's disease off-label use 34000006
Tendinitis off-label use 34840004 DOID:971
Rheumatic fever off-label use 58718002 DOID:1586
Ulcerative colitis off-label use 64766004 DOID:8577
Tenosynovitis off-label use 67801009 DOID:970
Juvenile rheumatoid arthritis off-label use 410795001
Itching of skin off-label use 418363000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.81 acidic
pKa2 12.79 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Carbonic anhydrase 2 Enzyme Ki 5.15 CHEMBL
Carbonic anhydrase 1 Enzyme Ki 5 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 4.95 CHEMBL
Carbonic anhydrase 9 Enzyme Ki 4.10 CHEMBL
Carbonic anhydrase 12 Enzyme Ki 5.06 CHEMBL
Carbonic anhydrase 7 Enzyme Ki 4.09 CHEMBL
Carbonic anhydrase 6 Enzyme Ki 4.92 CHEMBL
Carbonic anhydrase 14 Enzyme Ki 4.30 CHEMBL
High mobility group protein B1 Nuclear other Kd 6 CHEMBL
Nicotinate phosphoribosyltransferase Enzyme Ki 9.80 CHEMBL
Salicylic acid-binding protein 2 Enzyme WOMBAT-PK
Carbonic anhydrase 13 Enzyme Ki 4.17 CHEMBL
Polyphenol oxidase 2 Enzyme IC50 4 CHEMBL
Carbonic anhydrase 15 Enzyme Ki 5.14 CHEMBL
Solute carrier family 22 member 20 Transporter Ki 4.36 CHEMBL

External reference:

IDSource
4018663 VUID
N0000146974 NUI
D00097 KEGG_DRUG
2016-36-6 SECONDARY_CAS_RN
36364-49-5 SECONDARY_CAS_RN
4018419 VANDF
4018434 VANDF
4018663 VANDF
4018996 VANDF
C0036079 UMLSCUI
CHEBI:16914 CHEBI
SAL PDB_CHEM_ID
CHEMBL424 ChEMBL_ID
DB00936 DRUGBANK_ID
CHEMBL2104095 ChEMBL_ID
CHEMBL2104788 ChEMBL_ID
CHEMBL447868 ChEMBL_ID
D020156 MESH_DESCRIPTOR_UI
338 PUBCHEM_CID
C015075 MESH_SUPPLEMENTAL_RECORD_UI
4306 IUPHAR_LIGAND_ID
54-21-7 SECONDARY_CAS_RN
147-90-0 SECONDARY_CAS_RN
578-36-9 SECONDARY_CAS_RN
O414PZ4LPZ UNII
DB14006 DRUGBANK_ID
DB13860 DRUGBANK_ID
20974 RXNORM
4438 MMSL
5235 MMSL
5439 MMSL
5494 MMSL
9170 MMSL
d00492 MMSL
d00843 MMSL
001586 NDDF
001590 NDDF
001592 NDDF
001951 NDDF
005692 NDDF
006027 NDDF
370179008 SNOMEDCT_US
387253001 SNOMEDCT_US
387411000 SNOMEDCT_US
46741005 SNOMEDCT_US
65302009 SNOMEDCT_US
72968006 SNOMEDCT_US
D012980 MESH_DESCRIPTOR_UI
CHEMBL3707214 ChEMBL_ID
CHEMBL3707342 ChEMBL_ID
1938 INN_ID
5485 INN_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
SKIN MEDICA Purifying Foaming Wash HUMAN OTC DRUG LABEL 1 0023-4948 LIQUID 20 mg TOPICAL OTC monograph final 10 sections
Zapzyt Acne Wash Cleanser HUMAN OTC DRUG LABEL 1 0295-0071 GEL 2 g TOPICAL OTC monograph final 9 sections
Zapzyt Acne Wash Cleanser HUMAN OTC DRUG LABEL 1 0295-9055 GEL 2 g TOPICAL OTC monograph final 10 sections
Cetaphil Gentle Clear Mattifying Acne Moisturizer HUMAN OTC DRUG LABEL 1 0299-4117 LOTION 5 mg TOPICAL OTC monograph final 9 sections
Cetaphil Gentle Clear Mattifying Acne Moisturizer HUMAN OTC DRUG LABEL 1 0299-4117 LOTION 5 mg TOPICAL OTC monograph final 9 sections
Cetaphil Gentle Clear Clarifying Acne Cleanser HUMAN OTC DRUG LABEL 1 0299-4119 CREAM 20 mg TOPICAL OTC monograph final 10 sections
Cetaphil Gentle Clear Clarifying Acne Cleanser HUMAN OTC DRUG LABEL 1 0299-4119 CREAM 20 mg TOPICAL OTC monograph final 10 sections
Cetaphil Acne Relief Body Wash HUMAN OTC DRUG LABEL 1 0299-4121 GEL 20 mg TOPICAL OTC monograph final 10 sections
Cetaphil Acne Relief Body Wash HUMAN OTC DRUG LABEL 1 0299-4121 GEL 20 mg TOPICAL OTC monograph final 10 sections
Differin Acne Clearing Body Wash HUMAN OTC DRUG LABEL 1 0299-4131 GEL 20 mg TOPICAL OTC monograph final 11 sections
Differin Acne Clearing Body HUMAN OTC DRUG LABEL 1 0299-4132 AEROSOL, SPRAY 2 g TOPICAL OTC monograph final 11 sections
Cetaphil Gentle Clear Triple-Action Acne Serum HUMAN OTC DRUG LABEL 1 0299-4135 SOLUTION 5 mg TOPICAL OTC monograph final 9 sections
Differin Acne Clearing Body Scrub HUMAN OTC DRUG LABEL 1 0299-4609 LIQUID 20 mg TOPICAL OTC monograph final 10 sections
Differin Acne Clearing Body Scrub HUMAN OTC DRUG LABEL 1 0299-4609 LIQUID 20 mg TOPICAL OTC monograph final 10 sections
Almay Clear Complexion Liquid Makeup for Oily Skin HUMAN OTC DRUG LABEL 1 0311-0715 LIQUID 0.50 mg TOPICAL OTC monograph final 7 sections
Almay Clear Complexion Blemish Healing Spot Concealer HUMAN OTC DRUG LABEL 1 0311-0716 LIQUID 2 mg TOPICAL OTC monograph final 8 sections
Almay Clear Complexion Blemish Healing Spot Concealer HUMAN OTC DRUG LABEL 1 0311-0718 LIQUID 0.01 g TOPICAL OTC monograph final 8 sections
Almay Clear Complexion Liquid Makeup HUMAN OTC DRUG LABEL 1 0311-0720 LIQUID 2 mg TOPICAL OTC monograph final 8 sections
Almay Clear Complexion Pressed Powder HUMAN OTC DRUG LABEL 1 0311-0721 POWDER 0.00 g TOPICAL OTC monograph final 8 sections
Almay Clear Complexion Blemish Armor HUMAN OTC DRUG LABEL 1 0311-0722 LIQUID 2 mg TOPICAL OTC monograph final 10 sections
ALMAY CLEAR COMPLEXION MAKEUP HUMAN OTC DRUG LABEL 1 0311-0724 EMULSION 1 mg TOPICAL OTC monograph final 7 sections
ALMAY CLEAR COMPLEXION CONCEALER HUMAN OTC DRUG LABEL 1 0311-0725 LIQUID 2 mg TOPICAL OTC monograph final 8 sections
Salicylic acid HUMAN OTC DRUG LABEL 1 0363-0017 CREAM 5.05 mg TOPICAL OTC monograph final 10 sections
Salicylic acid HUMAN OTC DRUG LABEL 1 0363-0017 CREAM 5.05 mg TOPICAL OTC monograph final 10 sections
Charcoal Blackhead Clearing Scrub HUMAN OTC DRUG LABEL 1 0363-0027 CREAM 20.60 mg TOPICAL OTC monograph final 11 sections
Charcoal Blackhead Clearing Scrub HUMAN OTC DRUG LABEL 1 0363-0027 CREAM 20.60 mg TOPICAL OTC monograph final 11 sections
Salicylic Acid HUMAN OTC DRUG LABEL 1 0363-0203 PATCH 40 mg TOPICAL OTC monograph final 12 sections
Salicylic Acid HUMAN OTC DRUG LABEL 1 0363-0219 GEL 0.17 g TOPICAL OTC monograph final 14 sections
Oil-Free Daily Face HUMAN OTC DRUG LABEL 1 0363-0480 CREAM 2 g TOPICAL OTC monograph final 8 sections
Walgreens Oil-Free Acne Wash HUMAN OTC DRUG LABEL 1 0363-0536 SOLUTION 2 g TOPICAL OTC monograph final 9 sections