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ademetionine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2414 | 29908-03-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 62.74 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 2.50 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,FLT3,GRK2,ITK,MAP3K21,PDK1,PDK2,PIK3CD,PRKDC | 15 | |||
| kinase-selectivity-class | MAP2K6 | 1 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Confabulation | 122.21 | 34.01 | 16 | 795 | 304 | 90627332 |
| Serotonin syndrome | 74.65 | 34.01 | 23 | 788 | 37864 | 90589772 |
| Nystagmus | 72.40 | 34.01 | 16 | 795 | 7211 | 90620425 |
| Drug interaction | 63.58 | 34.01 | 36 | 775 | 276417 | 90351219 |
| Right aortic arch | 57.76 | 34.01 | 8 | 803 | 234 | 90627402 |
| Rhabdomyolysis | 56.20 | 34.01 | 20 | 791 | 51236 | 90576400 |
| Congenital arterial malformation | 55.25 | 34.01 | 8 | 803 | 323 | 90627313 |
| Dyskinesia | 46.73 | 34.01 | 16 | 795 | 36518 | 90591118 |
| Mechanical urticaria | 43.20 | 34.01 | 7 | 804 | 597 | 90627039 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Confabulation | 113.07 | 32.95 | 16 | 1058 | 505 | 110587720 |
| Nystagmus | 63.56 | 32.95 | 16 | 1058 | 11561 | 110576664 |
| Serotonin syndrome | 62.68 | 32.95 | 23 | 1051 | 59130 | 110529095 |
| Rhabdomyolysis | 46.91 | 32.95 | 23 | 1051 | 120378 | 110467847 |
| Drug interaction | 43.47 | 32.95 | 37 | 1037 | 500146 | 110088079 |
| Dyskinesia | 40.08 | 32.95 | 16 | 1058 | 51430 | 110536795 |
| Mechanical urticaria | 35.82 | 32.95 | 6 | 1068 | 577 | 110587648 |
| Clonus | 33.12 | 32.95 | 9 | 1065 | 8707 | 110579518 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A16AA02 | ALIMENTARY TRACT AND METABOLISM OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS Amino acids and derivatives |
| CHEBI has role | CHEBI:23354 | coenzymes |
| CHEBI has role | CHEBI:23357 | cofactor |
| CHEBI has role | CHEBI:27027 | trace elements |
| CHEBI has role | CHEBI:50733 | Dietary Supplement |
| CHEBI has role | CHEBI:75772 | S. cerevisiae metabolites |
| CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
| CHEBI has role | CHEBI:131604 | Mycoplasma genitalium metabolites |
Related Drugs by ATC class:
A16AA Amino acids and derivatives 6 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Hyperlipidemia | contraindication | 55822004 | DOID:1168 |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 2.53 | acidic |
| pKa2 | 12.47 | acidic |
| pKa3 | 9.91 | Basic |
| pKa4 | 3.95 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Protein arginine N-methyltransferase 1 | Enzyme | IC50 | 4.92 | CHEMBL | |||||
| Phenylethanolamine N-methyltransferase | Enzyme | Kd | 5.32 | CHEMBL | |||||
| Protein-beta-aspartate methyltransferase | Enzyme | Ki | 4.32 | CHEMBL | |||||
| S-adenosylmethionine decarboxylase proenzyme | Enzyme | Ki | 4.22 | CHEMBL | |||||
| Met repressor | Transcription factor | Kd | 8.40 | CHEMBL | |||||
| NS5 | Enzyme | Kd | 5.59 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4021429 | VUID |
| N0000148840 | NUI |
| D07128 | KEGG_DRUG |
| 4021429 | VANDF |
| C0036002 | UMLSCUI |
| SAM | PDB_CHEM_ID |
| CHEMBL1088977 | ChEMBL_ID |
| DB00118 | DRUGBANK_ID |
| C011501 | MESH_SUPPLEMENTAL_RECORD_UI |
| 5479 | INN_ID |
| 7LP2MPO46S | UNII |
| 34755 | PUBCHEM_CID |
| 9504 | RXNORM |
| 27892 | MMSL |
| 365023 | MMSL |
| d04524 | MMSL |
| 004313 | NDDF |
| 008834 | NDDF |
| 441671005 | SNOMEDCT_US |
| 441816007 | SNOMEDCT_US |
| D012436 | MESH_DESCRIPTOR_UI |
| CHEBI:15414 | CHEBI |
| 4786 | IUPHAR_LIGAND_ID |
| 7LP2MPO46S | INXIGHT DRUGS |
Pharmaceutical products:
None