Stem definition | Drug id | CAS RN |
---|---|---|
1311 | 56-85-9 |
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
June 10, 2004 | FDA | EMMAUS MEDCL |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Sickle cell anaemia with crisis | 73.52 | 22.39 | 18 | 1177 | 5985 | 63481842 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Sickle cell anaemia with crisis | 149.04 | 29.71 | 30 | 649 | 4023 | 34952229 |
Tendon calcification | 52.38 | 29.71 | 7 | 672 | 68 | 34956184 |
Acute chest syndrome | 48.03 | 29.71 | 9 | 670 | 818 | 34955434 |
Blood parathyroid hormone increased | 31.37 | 29.71 | 7 | 672 | 1507 | 34954745 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Sickle cell anaemia with crisis | 182.65 | 21.43 | 40 | 1526 | 7882 | 79734940 |
Tendon calcification | 47.16 | 21.43 | 7 | 1559 | 149 | 79742673 |
Acute chest syndrome | 42.20 | 21.43 | 9 | 1557 | 1552 | 79741270 |
Blood parathyroid hormone increased | 25.56 | 21.43 | 7 | 1559 | 3438 | 79739384 |
Tendon rupture | 23.95 | 21.43 | 9 | 1557 | 12117 | 79730705 |
None
Source | Code | Description |
---|---|---|
ATC | A16AA03 | ALIMENTARY TRACT AND METABOLISM OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS Amino acids and derivatives |
FDA CS | M0000922 | Amino Acids |
FDA EPC | N0000175780 | Amino Acid |
CHEBI has role | CHEBI:27027 | trace elements |
CHEBI has role | CHEBI:50733 | Dietary Supplement |
CHEBI has role | CHEBI:61908 | nitric oxide synthase inhibitors |
CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
CHEBI has role | CHEBI:75772 | S. cerevisiae metabolites |
CHEBI has role | CHEBI:76971 | Escherichia coli metabolites |
CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
CHEBI has role | CHEBI:78675 | fundamental metabolites |
CHEBI has role | CHEBI:25212 | metabolites |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Short bowel syndrome | indication | 26629001 | DOID:10605 |
Hb SS disease | symptomatic treatment | 127040003 | DOID:10923 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.17 | acidic |
pKa2 | 12.12 | acidic |
pKa3 | 9.22 | Basic |
None
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
5GM/PACKET | ENDARI | EMMAUS MEDCL | N208587 | July 7, 2017 | RX | FOR SOLUTION | ORAL | July 7, 2024 | TO REDUCE THE ACUTE COMPLICATIONS OF SICKLE CELL DISEASE IN ADULT AND PEDIATRIC PATIENTS 5 YEARS OF AGE AND OLDER. |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Amino acid transporter | Transporter | IC50 | 4.57 | CHEMBL |
ID | Source |
---|---|
4027901 | VUID |
N0000177918 | NUI |
4025874 | VANDF |
4027901 | VANDF |
C0017797 | UMLSCUI |
CHEBI:28300 | CHEBI |
GLN | PDB_CHEM_ID |
CHEMBL930 | ChEMBL_ID |
DB00130 | DRUGBANK_ID |
D005973 | MESH_DESCRIPTOR_UI |
5961 | PUBCHEM_CID |
1413 | INN_ID |
723 | IUPHAR_LIGAND_ID |
0RH81L854J | UNII |
4885 | RXNORM |
12067 | MMSL |
158599 | MMSL |
158601 | MMSL |
d07315 | MMSL |
000928 | NDDF |
25761002 | SNOMEDCT_US |
412421007 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Endari | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42457-420 | POWDER, FOR SOLUTION | 5 g | ORAL | NDA | 26 sections |
Endari | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42457-420 | POWDER, FOR SOLUTION | 5 g | ORAL | NDA | 26 sections |