Stem definition | Drug id | CAS RN |
---|---|---|
antihyperlipidaemic substances, HMG CoA reductase inhibitors | 2406 | 287714-41-4 |
Dose | Unit | Route |
---|---|---|
10 | mg | O |
Property | Value | Reference |
---|---|---|
MRTD (Maximum Recommended Therapeutic Daily Dose) | 1.19 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Hosey CM, Chan R, Benet LZ |
EoM (Fraction excreted unchanged in urine) | 30 % | Hosey CM, Chan R, Benet LZ |
BA (Bioavailability) | 20 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 1.70 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 11 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.12 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 2 hours | Lombardo F, Berellini G, Obach RS |
S (Water solubility) | 0.33 mg/mL | Bocci G, Oprea TI, Benet LZ |
Date | Agency | Company | Orphan |
---|---|---|---|
Aug. 12, 2003 | FDA | IPR | |
Jan. 19, 2005 | PMDA | AstraZeneca K.K. |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Rhabdomyolysis | 1210.49 | 9.59 | 1006 | 181329 | 42945 | 63263742 |
Myalgia | 916.28 | 9.59 | 1566 | 180769 | 144963 | 63161724 |
Maternal exposure during pregnancy | 505.53 | 9.59 | 32 | 182303 | 220030 | 63086657 |
Pemphigus | 456.43 | 9.59 | 16 | 182319 | 183710 | 63122977 |
Blood creatine phosphokinase increased | 444.32 | 9.59 | 491 | 181844 | 29939 | 63276748 |
Sedation complication | 421.59 | 9.59 | 336 | 181999 | 13486 | 63293201 |
Creatinine renal clearance decreased | 419.27 | 9.59 | 359 | 181976 | 15949 | 63290738 |
Orthostatic hypotension | 379.15 | 9.59 | 493 | 181842 | 35667 | 63271020 |
Systemic lupus erythematosus | 378.23 | 9.59 | 71 | 182264 | 208847 | 63097840 |
Glossodynia | 364.67 | 9.59 | 43 | 182292 | 178833 | 63127854 |
Hand deformity | 330.88 | 9.59 | 36 | 182299 | 159421 | 63147266 |
Cognitive disorder | 313.87 | 9.59 | 570 | 181765 | 55245 | 63251442 |
Anti-cyclic citrullinated peptide antibody positive | 308.04 | 9.59 | 5 | 182330 | 116207 | 63190480 |
Blood calcium decreased | 296.76 | 9.59 | 373 | 181962 | 26078 | 63280609 |
Contraindicated product administered | 291.60 | 9.59 | 130 | 182205 | 217518 | 63089169 |
Wound | 288.04 | 9.59 | 59 | 182276 | 163204 | 63143483 |
Exposure during pregnancy | 276.94 | 9.59 | 55 | 182280 | 155492 | 63151195 |
Treatment failure | 271.20 | 9.59 | 116 | 182219 | 198927 | 63107760 |
Sedation | 242.29 | 9.59 | 415 | 181920 | 38394 | 63268293 |
Synovitis | 242.05 | 9.59 | 117 | 182218 | 186801 | 63119886 |
Drug ineffective | 240.36 | 9.59 | 1890 | 180445 | 1042875 | 62263812 |
Balance disorder | 226.06 | 9.59 | 642 | 181693 | 83780 | 63222907 |
Duodenal ulcer perforation | 222.23 | 9.59 | 6 | 182329 | 87203 | 63219484 |
Pericarditis | 215.25 | 9.59 | 56 | 182279 | 131523 | 63175164 |
Myopathy | 210.79 | 9.59 | 207 | 182128 | 10984 | 63295703 |
Low density lipoprotein increased | 205.61 | 9.59 | 160 | 182175 | 6197 | 63300490 |
Arthropathy | 186.89 | 9.59 | 240 | 182095 | 234552 | 63072135 |
Acute kidney injury | 170.52 | 9.59 | 1317 | 181018 | 262098 | 63044589 |
Angina pectoris | 170.09 | 9.59 | 308 | 182027 | 29770 | 63276917 |
Helicobacter infection | 166.80 | 9.59 | 32 | 182303 | 92753 | 63213934 |
Folliculitis | 161.99 | 9.59 | 10 | 182325 | 70307 | 63236380 |
Therapeutic product effect decreased | 160.51 | 9.59 | 191 | 182144 | 192996 | 63113691 |
Product use issue | 155.10 | 9.59 | 246 | 182089 | 220274 | 63086413 |
Constipation | 149.62 | 9.59 | 1132 | 181203 | 223811 | 63082876 |
Infusion related reaction | 146.64 | 9.59 | 303 | 182032 | 245218 | 63061469 |
Depressed level of consciousness | 143.28 | 9.59 | 448 | 181887 | 61630 | 63245057 |
Muscle spasms | 137.96 | 9.59 | 843 | 181492 | 155307 | 63151380 |
Dyslipidaemia | 137.84 | 9.59 | 136 | 182199 | 7257 | 63299430 |
Impaired healing | 137.60 | 9.59 | 61 | 182274 | 102481 | 63204206 |
Drug intolerance | 132.57 | 9.59 | 449 | 181886 | 308212 | 62998475 |
Swelling | 129.16 | 9.59 | 385 | 181950 | 274993 | 63031694 |
Blood pressure increased | 125.96 | 9.59 | 847 | 181488 | 161215 | 63145472 |
Asthma | 124.49 | 9.59 | 707 | 181628 | 126854 | 63179833 |
Off label use | 120.12 | 9.59 | 1299 | 181036 | 673163 | 62633524 |
Discomfort | 119.28 | 9.59 | 185 | 182150 | 167189 | 63139498 |
Fall | 119.09 | 9.59 | 1681 | 180654 | 390653 | 62916034 |
Infection | 118.92 | 9.59 | 305 | 182030 | 228868 | 63077819 |
Completed suicide | 118.87 | 9.59 | 146 | 182189 | 145527 | 63161160 |
Sleep disorder due to general medical condition, insomnia type | 118.57 | 9.59 | 8 | 182327 | 52209 | 63254478 |
High density lipoprotein decreased | 117.83 | 9.59 | 75 | 182260 | 2095 | 63304592 |
Blister | 115.83 | 9.59 | 121 | 182214 | 129693 | 63176994 |
Blood glucose increased | 115.53 | 9.59 | 512 | 181823 | 83244 | 63223443 |
Alopecia | 115.12 | 9.59 | 538 | 181797 | 336998 | 62969689 |
Muscle injury | 110.35 | 9.59 | 26 | 182309 | 65319 | 63241368 |
Death | 108.98 | 9.59 | 630 | 181705 | 373751 | 62932936 |
Immune-mediated myositis | 108.53 | 9.59 | 60 | 182275 | 1283 | 63305404 |
Rheumatic fever | 106.12 | 9.59 | 4 | 182331 | 43107 | 63263580 |
Blood triglycerides increased | 104.86 | 9.59 | 153 | 182182 | 12335 | 63294352 |
Psoriasis | 104.79 | 9.59 | 511 | 181824 | 86446 | 63220241 |
Irritable bowel syndrome | 104.46 | 9.59 | 53 | 182282 | 82359 | 63224328 |
Hypotension | 102.40 | 9.59 | 1215 | 181120 | 271389 | 63035298 |
Euglycaemic diabetic ketoacidosis | 92.63 | 9.59 | 80 | 182255 | 3594 | 63303093 |
Full blood count abnormal | 91.55 | 9.59 | 248 | 182087 | 31469 | 63275218 |
Reversible airways obstruction | 91.01 | 9.59 | 60 | 182275 | 1782 | 63304905 |
Blood pressure systolic increased | 89.74 | 9.59 | 320 | 182015 | 47077 | 63259610 |
Drug interaction | 89.01 | 9.59 | 1028 | 181307 | 228103 | 63078584 |
Vital capacity decreased | 87.11 | 9.59 | 57 | 182278 | 1671 | 63305016 |
Abdominal discomfort | 87.02 | 9.59 | 552 | 181783 | 320333 | 62986354 |
General physical health deterioration | 86.36 | 9.59 | 293 | 182042 | 201109 | 63105578 |
Pregnancy | 85.56 | 9.59 | 5 | 182330 | 36831 | 63269856 |
Asthenia | 83.86 | 9.59 | 1557 | 180778 | 382047 | 62924640 |
Obstructive airways disorder | 78.91 | 9.59 | 180 | 182155 | 20519 | 63286168 |
Disease progression | 77.96 | 9.59 | 146 | 182189 | 122612 | 63184075 |
Renal failure | 77.49 | 9.59 | 591 | 181744 | 117061 | 63189626 |
Abortion spontaneous | 77.31 | 9.59 | 20 | 182315 | 47175 | 63259512 |
Blood immunoglobulin E increased | 75.86 | 9.59 | 73 | 182262 | 3776 | 63302911 |
Sputum culture positive | 75.47 | 9.59 | 57 | 182278 | 2110 | 63304577 |
Hip arthroplasty | 72.86 | 9.59 | 23 | 182312 | 47623 | 63259064 |
Muscular weakness | 72.58 | 9.59 | 600 | 181735 | 121753 | 63184934 |
Hypersensitivity | 72.58 | 9.59 | 517 | 181818 | 292168 | 63014519 |
Diabetic ketoacidosis | 70.21 | 9.59 | 171 | 182164 | 20334 | 63286353 |
Device expulsion | 69.62 | 9.59 | 9 | 182326 | 34913 | 63271774 |
Bronchiectasis | 69.03 | 9.59 | 147 | 182188 | 15995 | 63290692 |
Myocardial infarction | 68.72 | 9.59 | 507 | 181828 | 99386 | 63207301 |
Rheumatoid factor positive | 67.36 | 9.59 | 86 | 182249 | 84320 | 63222367 |
Cough | 67.34 | 9.59 | 1198 | 181137 | 291545 | 63015142 |
Arterial occlusive disease | 66.78 | 9.59 | 84 | 182251 | 5874 | 63300813 |
Stomatitis | 66.37 | 9.59 | 192 | 182143 | 138533 | 63168154 |
Intentional overdose | 66.25 | 9.59 | 69 | 182266 | 74083 | 63232604 |
Bronchial secretion retention | 65.13 | 9.59 | 58 | 182277 | 2715 | 63303972 |
Malignant mediastinal neoplasm | 64.02 | 9.59 | 44 | 182291 | 1402 | 63305285 |
Cystitis | 63.98 | 9.59 | 320 | 182015 | 54671 | 63252016 |
Drug abuse | 63.09 | 9.59 | 69 | 182266 | 72449 | 63234238 |
Hypoglycaemia | 61.93 | 9.59 | 338 | 181997 | 59727 | 63246960 |
Foetal exposure during pregnancy | 59.64 | 9.59 | 10 | 182325 | 31952 | 63274735 |
Skin haemorrhage | 57.86 | 9.59 | 104 | 182231 | 9990 | 63296697 |
Sinus congestion | 57.70 | 9.59 | 147 | 182188 | 17976 | 63288711 |
Premature delivery | 57.57 | 9.59 | 9 | 182326 | 30272 | 63276415 |
Nephritic syndrome | 57.33 | 9.59 | 25 | 182310 | 311 | 63306376 |
Carotid artery thrombosis | 56.98 | 9.59 | 54 | 182281 | 2740 | 63303947 |
Hepatic enzyme increased | 56.89 | 9.59 | 344 | 181991 | 201984 | 63104703 |
Neurologic neglect syndrome | 56.28 | 9.59 | 53 | 182282 | 2668 | 63304019 |
Chronic kidney disease | 56.26 | 9.59 | 269 | 182066 | 45129 | 63261558 |
Pain in extremity | 54.57 | 9.59 | 1291 | 181044 | 330195 | 62976492 |
Blood creatinine increased | 53.82 | 9.59 | 434 | 181901 | 87410 | 63219277 |
Joint swelling | 53.78 | 9.59 | 642 | 181693 | 327024 | 62979663 |
Condition aggravated | 53.77 | 9.59 | 822 | 181513 | 401395 | 62905292 |
Hyper IgE syndrome | 53.15 | 9.59 | 27 | 182308 | 483 | 63306204 |
Injury | 53.06 | 9.59 | 80 | 182255 | 73167 | 63233520 |
Gangrene | 51.38 | 9.59 | 75 | 182260 | 6048 | 63300639 |
Restrictive pulmonary disease | 51.26 | 9.59 | 42 | 182293 | 1753 | 63304934 |
Product use in unapproved indication | 51.11 | 9.59 | 303 | 182032 | 178777 | 63127910 |
Rash | 51.09 | 9.59 | 1224 | 181111 | 559647 | 62747040 |
Neutropenia | 51.07 | 9.59 | 294 | 182041 | 174711 | 63131976 |
Low density lipoprotein decreased | 47.73 | 9.59 | 20 | 182315 | 224 | 63306463 |
Nasal oedema | 46.40 | 9.59 | 37 | 182298 | 1485 | 63305202 |
Coma | 45.95 | 9.59 | 71 | 182264 | 64293 | 63242394 |
Foetal acidosis | 45.82 | 9.59 | 11 | 182324 | 11 | 63306676 |
Pancreatic neuroendocrine tumour | 45.45 | 9.59 | 23 | 182312 | 408 | 63306279 |
Ischaemic stroke | 43.65 | 9.59 | 132 | 182203 | 17825 | 63288862 |
Tubulointerstitial nephritis | 43.49 | 9.59 | 141 | 182194 | 19762 | 63286925 |
Diabetes mellitus inadequate control | 43.37 | 9.59 | 118 | 182217 | 15008 | 63291679 |
Dermatitis allergic | 43.26 | 9.59 | 118 | 182217 | 15030 | 63291657 |
Cataract | 42.95 | 9.59 | 296 | 182039 | 56757 | 63249930 |
Glycosylated haemoglobin increased | 42.03 | 9.59 | 103 | 182232 | 12295 | 63294392 |
Diabetes mellitus | 41.69 | 9.59 | 289 | 182046 | 55521 | 63251166 |
Pancytopenia | 41.52 | 9.59 | 141 | 182194 | 96792 | 63209895 |
Respiratory tract infection | 41.13 | 9.59 | 231 | 182104 | 41252 | 63265435 |
Liver disorder | 40.69 | 9.59 | 279 | 182056 | 53408 | 63253279 |
Angina unstable | 40.54 | 9.59 | 73 | 182262 | 7022 | 63299665 |
Hyperglycaemia | 40.10 | 9.59 | 231 | 182104 | 41636 | 63265051 |
Coronary artery disease | 39.50 | 9.59 | 191 | 182144 | 32186 | 63274501 |
Eosinophil count increased | 39.42 | 9.59 | 93 | 182242 | 10835 | 63295852 |
Adjustment disorder | 39.16 | 9.59 | 47 | 182288 | 3131 | 63303556 |
Pancreatitis | 39.02 | 9.59 | 258 | 182077 | 48797 | 63257890 |
Drug tolerance decreased | 38.74 | 9.59 | 3 | 182332 | 17470 | 63289217 |
Drug-induced liver injury | 38.57 | 9.59 | 222 | 182113 | 40000 | 63266687 |
Adverse event | 38.08 | 9.59 | 86 | 182249 | 67473 | 63239214 |
Muscle discomfort | 37.96 | 9.59 | 16 | 182319 | 182 | 63306505 |
Ulnar tunnel syndrome | 37.49 | 9.59 | 9 | 182326 | 9 | 63306678 |
Lactic acidosis | 37.16 | 9.59 | 212 | 182123 | 38075 | 63268612 |
Affect lability | 37.12 | 9.59 | 92 | 182243 | 11059 | 63295628 |
Therapy non-responder | 37.06 | 9.59 | 104 | 182231 | 75797 | 63230890 |
Mobility decreased | 36.95 | 9.59 | 520 | 181815 | 120639 | 63186048 |
Alanine aminotransferase increased | 36.90 | 9.59 | 458 | 181877 | 103312 | 63203375 |
Paroxysmal extreme pain disorder | 36.85 | 9.59 | 13 | 182322 | 87 | 63306600 |
Seizure | 36.48 | 9.59 | 227 | 182108 | 132407 | 63174280 |
Degenerative bone disease | 36.44 | 9.59 | 15 | 182320 | 160 | 63306527 |
Gastrointestinal disorder | 36.41 | 9.59 | 224 | 182111 | 131015 | 63175672 |
Cerebrovascular accident | 36.38 | 9.59 | 472 | 181863 | 107552 | 63199135 |
Blood test abnormal | 36.23 | 9.59 | 113 | 182222 | 15516 | 63291171 |
Febrile neutropenia | 36.17 | 9.59 | 196 | 182139 | 118253 | 63188434 |
Palpitations | 36.01 | 9.59 | 488 | 181847 | 112282 | 63194405 |
Fibromyalgia | 35.81 | 9.59 | 115 | 182220 | 80305 | 63226382 |
Blood calcium increased | 35.29 | 9.59 | 81 | 182254 | 9269 | 63297418 |
Chromaturia | 35.24 | 9.59 | 117 | 182218 | 16600 | 63290087 |
Intentional product use issue | 35.11 | 9.59 | 219 | 182116 | 127673 | 63179014 |
Injection site reaction | 35.06 | 9.59 | 72 | 182263 | 58452 | 63248235 |
Intentional self-injury | 34.89 | 9.59 | 15 | 182320 | 25672 | 63281015 |
Lipids increased | 34.17 | 9.59 | 28 | 182307 | 1169 | 63305518 |
Glomerular filtration rate decreased | 33.80 | 9.59 | 100 | 182235 | 13341 | 63293346 |
Grip strength decreased | 33.64 | 9.59 | 11 | 182324 | 22276 | 63284411 |
Weight decreased | 33.23 | 9.59 | 1035 | 181300 | 275763 | 63030924 |
Upper-airway cough syndrome | 32.66 | 9.59 | 89 | 182246 | 11329 | 63295358 |
Prescribed overdose | 32.56 | 9.59 | 30 | 182305 | 34123 | 63272564 |
Hepatocellular injury | 32.31 | 9.59 | 160 | 182175 | 27221 | 63279466 |
Hepatitis | 32.09 | 9.59 | 210 | 182125 | 39578 | 63267109 |
Product substitution issue | 32.00 | 9.59 | 110 | 182225 | 15886 | 63290801 |
Transaminases increased | 31.98 | 9.59 | 176 | 182159 | 31191 | 63275496 |
Chronic respiratory disease | 31.97 | 9.59 | 14 | 182321 | 176 | 63306511 |
Total lung capacity decreased | 31.46 | 9.59 | 35 | 182300 | 2148 | 63304539 |
Myositis | 31.43 | 9.59 | 77 | 182258 | 9189 | 63297498 |
Androgenetic alopecia | 31.15 | 9.59 | 13 | 182322 | 144 | 63306543 |
Ill-defined disorder | 31.03 | 9.59 | 125 | 182210 | 81630 | 63225057 |
Confabulation | 30.63 | 9.59 | 16 | 182319 | 304 | 63306383 |
Confusional arousal | 30.63 | 9.59 | 14 | 182321 | 196 | 63306491 |
Cytomegalovirus infection | 30.49 | 9.59 | 11 | 182324 | 20941 | 63285746 |
Therapeutic product effect incomplete | 30.41 | 9.59 | 222 | 182113 | 124834 | 63181853 |
Multiple allergies | 30.36 | 9.59 | 98 | 182237 | 13704 | 63292983 |
Caesarean section | 30.33 | 9.59 | 6 | 182329 | 17026 | 63289661 |
Pulmonary mass | 30.28 | 9.59 | 137 | 182198 | 22459 | 63284228 |
Adverse drug reaction | 30.18 | 9.59 | 122 | 182213 | 79592 | 63227095 |
Hemiplegia | 30.07 | 9.59 | 76 | 182259 | 9247 | 63297440 |
Coronary artery occlusion | 29.86 | 9.59 | 70 | 182265 | 8121 | 63298566 |
Post procedural hypothyroidism | 29.75 | 9.59 | 15 | 182320 | 264 | 63306423 |
Sensory loss | 29.49 | 9.59 | 80 | 182255 | 10158 | 63296529 |
Polymyositis | 29.47 | 9.59 | 31 | 182304 | 1785 | 63304902 |
Generalised tonic-clonic seizure | 29.47 | 9.59 | 24 | 182311 | 28992 | 63277695 |
Vertigo | 28.97 | 9.59 | 281 | 182054 | 59606 | 63247081 |
Knee arthroplasty | 28.95 | 9.59 | 71 | 182264 | 54135 | 63252552 |
Burning sensation | 28.68 | 9.59 | 260 | 182075 | 54147 | 63252540 |
Multi-organ disorder | 28.53 | 9.59 | 28 | 182307 | 1484 | 63305203 |
Cerebral infarction | 28.46 | 9.59 | 140 | 182195 | 23753 | 63282934 |
Lower respiratory tract infection | 27.95 | 9.59 | 244 | 182091 | 132063 | 63174624 |
Blood pressure systolic abnormal | 27.61 | 9.59 | 93 | 182242 | 13293 | 63293394 |
Pyrexia | 27.45 | 9.59 | 1089 | 181246 | 469389 | 62837298 |
Amblyopia | 27.24 | 9.59 | 14 | 182321 | 257 | 63306430 |
Blood glucose abnormal | 27.21 | 9.59 | 66 | 182269 | 7826 | 63298861 |
Suicide attempt | 27.19 | 9.59 | 87 | 182248 | 60831 | 63245856 |
Necrotising myositis | 27.17 | 9.59 | 18 | 182317 | 539 | 63306148 |
Polymyalgia rheumatica | 26.96 | 9.59 | 43 | 182292 | 3748 | 63302939 |
Food interaction | 26.90 | 9.59 | 21 | 182314 | 817 | 63305870 |
Respiratory tract congestion | 26.87 | 9.59 | 112 | 182223 | 17720 | 63288967 |
Crush syndrome | 26.67 | 9.59 | 11 | 182324 | 118 | 63306569 |
Device dislocation | 26.43 | 9.59 | 21 | 182314 | 25684 | 63281003 |
Rhinorrhoea | 26.20 | 9.59 | 296 | 182039 | 65281 | 63241406 |
Acute myocardial infarction | 26.18 | 9.59 | 170 | 182165 | 31954 | 63274733 |
Personality disorder | 26.10 | 9.59 | 54 | 182281 | 5757 | 63300930 |
Pertussis | 25.91 | 9.59 | 19 | 182316 | 672 | 63306015 |
Thrombocytopenia | 25.59 | 9.59 | 294 | 182041 | 150863 | 63155824 |
Myopathy toxic | 25.55 | 9.59 | 17 | 182318 | 513 | 63306174 |
Respiratory arrest | 25.28 | 9.59 | 34 | 182301 | 32611 | 63274076 |
Leukopenia | 25.22 | 9.59 | 125 | 182210 | 77165 | 63229522 |
Chest discomfort | 25.20 | 9.59 | 450 | 181885 | 109519 | 63197168 |
Chest pain | 24.97 | 9.59 | 804 | 181531 | 215155 | 63091532 |
Blood pressure diastolic decreased | 24.91 | 9.59 | 130 | 182205 | 22576 | 63284111 |
Hernia | 24.74 | 9.59 | 86 | 182249 | 12488 | 63294199 |
Sepsis | 24.70 | 9.59 | 301 | 182034 | 152822 | 63153865 |
Haemorrhagic diathesis | 24.68 | 9.59 | 45 | 182290 | 4370 | 63302317 |
Facet joint syndrome | 24.50 | 9.59 | 3 | 182332 | 12135 | 63294552 |
Microalbuminuria | 24.48 | 9.59 | 15 | 182320 | 391 | 63306296 |
Blood pressure inadequately controlled | 24.44 | 9.59 | 48 | 182287 | 4930 | 63301757 |
Gastrooesophageal reflux disease | 24.32 | 9.59 | 398 | 181937 | 95241 | 63211446 |
Thyroid disorder | 24.24 | 9.59 | 97 | 182238 | 15065 | 63291622 |
Endocrine ophthalmopathy | 24.15 | 9.59 | 18 | 182317 | 653 | 63306034 |
Hyperlactacidaemia | 24.05 | 9.59 | 35 | 182300 | 2814 | 63303873 |
Discontinued product administered | 24.03 | 9.59 | 9 | 182326 | 73 | 63306614 |
Blood creatine increased | 23.94 | 9.59 | 51 | 182284 | 5550 | 63301137 |
HIV infection | 23.92 | 9.59 | 15 | 182320 | 408 | 63306279 |
Eyelid disorder | 23.86 | 9.59 | 28 | 182307 | 1821 | 63304866 |
Transcription medication error | 23.86 | 9.59 | 12 | 182323 | 210 | 63306477 |
Ulcer | 23.65 | 9.59 | 24 | 182311 | 26083 | 63280604 |
Lung diffusion test decreased | 23.51 | 9.59 | 18 | 182317 | 680 | 63306007 |
Toxic epidermal necrolysis | 23.28 | 9.59 | 23 | 182312 | 25311 | 63281376 |
Blood pressure fluctuation | 23.23 | 9.59 | 219 | 182116 | 46098 | 63260589 |
Creutzfeldt-Jakob disease | 22.98 | 9.59 | 11 | 182324 | 172 | 63306515 |
Drug ineffective for unapproved indication | 22.97 | 9.59 | 39 | 182296 | 34024 | 63272663 |
Goitre | 22.90 | 9.59 | 52 | 182283 | 5909 | 63300778 |
Myoglobin blood increased | 22.83 | 9.59 | 24 | 182311 | 1381 | 63305306 |
Hepatic enzyme abnormal | 22.62 | 9.59 | 54 | 182281 | 6338 | 63300349 |
Sneezing | 22.60 | 9.59 | 108 | 182227 | 18110 | 63288577 |
Parosmia | 22.59 | 9.59 | 53 | 182282 | 6153 | 63300534 |
Toxic shock syndrome | 22.59 | 9.59 | 19 | 182316 | 823 | 63305864 |
Hyperkeratosis | 22.57 | 9.59 | 52 | 182283 | 5966 | 63300721 |
Atrial fibrillation | 22.54 | 9.59 | 465 | 181870 | 116171 | 63190516 |
Listless | 22.52 | 9.59 | 34 | 182301 | 2826 | 63303861 |
Bronchopulmonary aspergillosis allergic | 22.44 | 9.59 | 30 | 182305 | 2228 | 63304459 |
Cardiac murmur | 22.40 | 9.59 | 92 | 182243 | 14460 | 63292227 |
Coronary artery stenosis | 22.39 | 9.59 | 45 | 182290 | 4699 | 63301988 |
Aspartate aminotransferase increased | 22.34 | 9.59 | 374 | 181961 | 89903 | 63216784 |
Muscle disorder | 22.11 | 9.59 | 46 | 182289 | 4923 | 63301764 |
Rheumatic disorder | 22.06 | 9.59 | 35 | 182300 | 3037 | 63303650 |
Malaise | 21.78 | 9.59 | 1429 | 180906 | 414525 | 62892162 |
Skin exfoliation | 21.72 | 9.59 | 204 | 182131 | 42898 | 63263789 |
Respiratory failure | 21.44 | 9.59 | 188 | 182147 | 101670 | 63205017 |
Blood creatine phosphokinase | 21.38 | 9.59 | 6 | 182329 | 16 | 63306671 |
Sinonasal obstruction | 21.32 | 9.59 | 12 | 182323 | 266 | 63306421 |
Sinus disorder | 21.29 | 9.59 | 132 | 182203 | 24421 | 63282266 |
Rales | 20.92 | 9.59 | 82 | 182253 | 12615 | 63294072 |
Catarrh | 20.90 | 9.59 | 24 | 182311 | 1525 | 63305162 |
Lipids abnormal | 20.73 | 9.59 | 12 | 182323 | 281 | 63306406 |
Hypereosinophilic syndrome | 20.62 | 9.59 | 12 | 182323 | 284 | 63306403 |
Acute coronary syndrome | 20.57 | 9.59 | 70 | 182265 | 10056 | 63296631 |
Rheumatoid nodule | 20.32 | 9.59 | 12 | 182323 | 17143 | 63289544 |
Hypopnoea | 20.28 | 9.59 | 38 | 182297 | 3768 | 63302919 |
Sleep disorder due to a general medical condition | 20.28 | 9.59 | 5 | 182330 | 12183 | 63294504 |
Blood pressure abnormal | 20.25 | 9.59 | 92 | 182243 | 15106 | 63291581 |
Dyspnoea exertional | 20.09 | 9.59 | 263 | 182072 | 60039 | 63246648 |
Body temperature decreased | 20.04 | 9.59 | 113 | 182222 | 20206 | 63286481 |
Albuminuria | 20.03 | 9.59 | 11 | 182324 | 232 | 63306455 |
Premature baby | 20.02 | 9.59 | 18 | 182317 | 20717 | 63285970 |
Blood creatine phosphokinase abnormal | 19.99 | 9.59 | 11 | 182324 | 233 | 63306454 |
Drug specific antibody | 19.98 | 9.59 | 29 | 182306 | 2326 | 63304361 |
Blood cholesterol abnormal | 19.97 | 9.59 | 31 | 182304 | 2640 | 63304047 |
Anuria | 19.83 | 9.59 | 80 | 182255 | 12471 | 63294216 |
Hepatic function abnormal | 19.83 | 9.59 | 178 | 182157 | 36964 | 63269723 |
Motor dysfunction | 19.80 | 9.59 | 72 | 182263 | 10689 | 63295998 |
Metabolic acidosis | 19.65 | 9.59 | 207 | 182128 | 44862 | 63261825 |
Muscle contractions involuntary | 19.64 | 9.59 | 29 | 182306 | 2363 | 63304324 |
Procollagen type I C-terminal propeptide increased | 19.55 | 9.59 | 6 | 182329 | 24 | 63306663 |
Cardio-respiratory arrest | 19.54 | 9.59 | 97 | 182238 | 59862 | 63246825 |
Lip dry | 19.52 | 9.59 | 10 | 182325 | 15460 | 63291227 |
Red blood cell sedimentation rate abnormal | 19.50 | 9.59 | 110 | 182225 | 19672 | 63287015 |
Arthritis | 19.48 | 9.59 | 453 | 181882 | 115468 | 63191219 |
Blood immunoglobulin M increased | 19.43 | 9.59 | 20 | 182315 | 1123 | 63305564 |
Metastases to bone | 19.41 | 9.59 | 19 | 182316 | 21000 | 63285687 |
Reduced facial expression | 19.35 | 9.59 | 26 | 182309 | 1940 | 63304747 |
Bone marrow failure | 19.33 | 9.59 | 34 | 182301 | 29256 | 63277431 |
Blood immunoglobulin G increased | 19.32 | 9.59 | 29 | 182306 | 2398 | 63304289 |
Pulmonary function test abnormal | 19.25 | 9.59 | 25 | 182310 | 1805 | 63304882 |
Burns second degree | 19.23 | 9.59 | 26 | 182309 | 1952 | 63304735 |
Transient ischaemic attack | 19.18 | 9.59 | 179 | 182156 | 37574 | 63269113 |
Nightmare | 19.10 | 9.59 | 107 | 182228 | 19087 | 63287600 |
Dizziness | 19.04 | 9.59 | 1457 | 180878 | 428468 | 62878219 |
Tongue discomfort | 19.02 | 9.59 | 28 | 182307 | 2275 | 63304412 |
Influenza | 18.93 | 9.59 | 427 | 181908 | 108295 | 63198392 |
Endometriosis | 18.89 | 9.59 | 45 | 182290 | 5275 | 63301412 |
Serum procollagen type I N-terminal propeptide increased | 18.81 | 9.59 | 6 | 182329 | 28 | 63306659 |
Sputum culture | 18.80 | 9.59 | 11 | 182324 | 263 | 63306424 |
Neutropenic sepsis | 18.78 | 9.59 | 12 | 182323 | 16426 | 63290261 |
Transplant rejection | 18.78 | 9.59 | 4 | 182331 | 10776 | 63295911 |
Swelling of eyelid | 18.71 | 9.59 | 33 | 182302 | 3123 | 63303564 |
Infusion site streaking | 18.71 | 9.59 | 14 | 182321 | 511 | 63306176 |
Poisoning | 18.60 | 9.59 | 8 | 182327 | 13692 | 63292995 |
Degenerative aortic valve disease | 18.51 | 9.59 | 9 | 182326 | 146 | 63306541 |
Device related infection | 18.48 | 9.59 | 24 | 182311 | 23368 | 63283319 |
Blood parathyroid hormone decreased | 18.41 | 9.59 | 3 | 182332 | 9788 | 63296899 |
Panniculitis | 18.31 | 9.59 | 5 | 182330 | 11380 | 63295307 |
Pancreatitis acute | 18.16 | 9.59 | 137 | 182198 | 27029 | 63279658 |
Malignant neoplasm progression | 17.98 | 9.59 | 150 | 182185 | 81971 | 63224716 |
Renal impairment | 17.98 | 9.59 | 355 | 181980 | 88000 | 63218687 |
Blood pressure diastolic abnormal | 17.89 | 9.59 | 86 | 182249 | 14456 | 63292231 |
Infected dermal cyst | 17.87 | 9.59 | 13 | 182322 | 454 | 63306233 |
Multiple sclerosis relapse | 17.84 | 9.59 | 75 | 182260 | 48403 | 63258284 |
COVID-19 | 17.79 | 9.59 | 438 | 181897 | 112665 | 63194022 |
Multiple drug therapy | 17.71 | 9.59 | 35 | 182300 | 3611 | 63303076 |
Mucosal inflammation | 17.65 | 9.59 | 72 | 182263 | 46856 | 63259831 |
Skin necrosis | 17.63 | 9.59 | 9 | 182326 | 13941 | 63292746 |
Urine albumin/creatinine ratio increased | 17.58 | 9.59 | 11 | 182324 | 298 | 63306389 |
Chronic spontaneous urticaria | 17.45 | 9.59 | 19 | 182316 | 1138 | 63305549 |
Lung opacity | 17.35 | 9.59 | 32 | 182303 | 3136 | 63303551 |
Lipoprotein (a) increased | 17.29 | 9.59 | 6 | 182329 | 38 | 63306649 |
Injection site erythema | 17.29 | 9.59 | 154 | 182181 | 83020 | 63223667 |
Macular degeneration | 17.29 | 9.59 | 27 | 182308 | 24349 | 63282338 |
Infrequent bowel movements | 17.28 | 9.59 | 20 | 182315 | 1282 | 63305405 |
Bone erosion | 17.12 | 9.59 | 98 | 182237 | 17619 | 63289068 |
Respiratory depression | 17.11 | 9.59 | 9 | 182326 | 13706 | 63292981 |
Interstitial lung disease | 17.01 | 9.59 | 261 | 182074 | 61647 | 63245040 |
Hyperlipasaemia | 16.92 | 9.59 | 15 | 182320 | 698 | 63305989 |
Total cholesterol/HDL ratio abnormal | 16.82 | 9.59 | 7 | 182328 | 77 | 63306610 |
Bursitis infective | 16.78 | 9.59 | 20 | 182315 | 1323 | 63305364 |
Akathisia | 16.76 | 9.59 | 3 | 182332 | 9143 | 63297544 |
Unwanted awareness during anaesthesia | 16.68 | 9.59 | 11 | 182324 | 327 | 63306360 |
Therapy partial responder | 16.55 | 9.59 | 5 | 182330 | 10653 | 63296034 |
Peripheral sensorimotor neuropathy | 16.54 | 9.59 | 21 | 182314 | 1482 | 63305205 |
Lymphopenia | 16.43 | 9.59 | 17 | 182318 | 18310 | 63288377 |
Head discomfort | 16.26 | 9.59 | 79 | 182256 | 13336 | 63293351 |
Sopor | 16.25 | 9.59 | 24 | 182311 | 22140 | 63284547 |
Status epilepticus | 16.23 | 9.59 | 12 | 182323 | 15221 | 63291466 |
Haemorrhage subcutaneous | 16.17 | 9.59 | 30 | 182305 | 2953 | 63303734 |
Poisoning deliberate | 16.14 | 9.59 | 6 | 182329 | 11212 | 63295475 |
Apolipoprotein A-I decreased | 16.10 | 9.59 | 5 | 182330 | 21 | 63306666 |
Malignant melanoma | 16.08 | 9.59 | 70 | 182265 | 11286 | 63295401 |
Eye disorder | 16.08 | 9.59 | 116 | 182219 | 22569 | 63284118 |
Premature labour | 15.90 | 9.59 | 8 | 182327 | 12496 | 63294191 |
Stent placement | 15.83 | 9.59 | 34 | 182301 | 3721 | 63302966 |
Arteriosclerosis | 15.78 | 9.59 | 64 | 182271 | 10002 | 63296685 |
Breast cancer stage II | 15.72 | 9.59 | 3 | 182332 | 8733 | 63297954 |
Hyperlipidaemia | 15.60 | 9.59 | 103 | 182232 | 19468 | 63287219 |
Ligament pain | 15.58 | 9.59 | 9 | 182326 | 210 | 63306477 |
Diffuse alopecia | 15.52 | 9.59 | 16 | 182319 | 900 | 63305787 |
Needle issue | 15.50 | 9.59 | 65 | 182270 | 10311 | 63296376 |
Blood immunoglobulin A decreased | 15.45 | 9.59 | 19 | 182316 | 1298 | 63305389 |
Erythema multiforme | 15.42 | 9.59 | 64 | 182271 | 10105 | 63296582 |
Eczema | 15.36 | 9.59 | 151 | 182184 | 32140 | 63274547 |
Device issue | 15.34 | 9.59 | 28 | 182307 | 23753 | 63282934 |
Sensorimotor disorder | 15.21 | 9.59 | 12 | 182323 | 474 | 63306213 |
Hypertriglyceridaemia | 15.20 | 9.59 | 46 | 182289 | 6213 | 63300474 |
Hyperplastic cholecystopathy | 15.18 | 9.59 | 8 | 182327 | 155 | 63306532 |
Intensive care unit acquired weakness | 15.11 | 9.59 | 15 | 182320 | 806 | 63305881 |
Musculoskeletal stiffness | 15.09 | 9.59 | 409 | 181926 | 184209 | 63122478 |
Basophil count increased | 14.93 | 9.59 | 16 | 182319 | 941 | 63305746 |
Eye haemorrhage | 14.93 | 9.59 | 56 | 182279 | 8440 | 63298247 |
Gestational diabetes | 14.86 | 9.59 | 3 | 182332 | 8393 | 63298294 |
Amylase increased | 14.82 | 9.59 | 46 | 182289 | 6299 | 63300388 |
Mean cell volume increased | 14.79 | 9.59 | 32 | 182303 | 3519 | 63303168 |
Night sweats | 14.77 | 9.59 | 81 | 182254 | 48733 | 63257954 |
Psoriatic arthropathy | 14.71 | 9.59 | 180 | 182155 | 91340 | 63215347 |
Pre-eclampsia | 14.71 | 9.59 | 4 | 182331 | 9129 | 63297558 |
Musculoskeletal toxicity | 14.66 | 9.59 | 6 | 182329 | 63 | 63306624 |
Rotator cuff syndrome | 14.60 | 9.59 | 77 | 182258 | 13425 | 63293262 |
Foreign body | 14.58 | 9.59 | 25 | 182310 | 2313 | 63304374 |
Dystonia | 14.58 | 9.59 | 11 | 182324 | 13808 | 63292879 |
Neurotrophic keratopathy | 14.57 | 9.59 | 3 | 182332 | 0 | 63306687 |
Decubitus ulcer | 14.52 | 9.59 | 6 | 182329 | 10514 | 63296173 |
Coma acidotic | 14.42 | 9.59 | 7 | 182328 | 113 | 63306574 |
Colitis microscopic | 14.34 | 9.59 | 59 | 182276 | 9280 | 63297407 |
Hypocholesterolaemia | 14.31 | 9.59 | 7 | 182328 | 115 | 63306572 |
Clitoris abscess | 14.17 | 9.59 | 4 | 182331 | 11 | 63306676 |
Aspergillus infection | 14.10 | 9.59 | 3 | 182332 | 8090 | 63298597 |
Occult blood | 14.04 | 9.59 | 18 | 182317 | 1283 | 63305404 |
Dyspnoea | 13.98 | 9.59 | 2133 | 180202 | 659180 | 62647507 |
Hyperphosphataemia | 13.97 | 9.59 | 24 | 182311 | 2224 | 63304463 |
Liver injury | 13.96 | 9.59 | 109 | 182226 | 60411 | 63246276 |
Cardiac neoplasm unspecified | 13.95 | 9.59 | 6 | 182329 | 72 | 63306615 |
Steroid dependence | 13.93 | 9.59 | 21 | 182314 | 1743 | 63304944 |
Neurotoxicity | 13.87 | 9.59 | 17 | 182318 | 16973 | 63289714 |
Restless legs syndrome | 13.86 | 9.59 | 96 | 182239 | 18435 | 63288252 |
Chronic sinusitis | 13.83 | 9.59 | 10 | 182325 | 12833 | 63293854 |
Neutrophil count decreased | 13.77 | 9.59 | 100 | 182235 | 56306 | 63250381 |
Muscle atrophy | 13.75 | 9.59 | 48 | 182287 | 6985 | 63299702 |
Mixed liver injury | 13.64 | 9.59 | 37 | 182298 | 4698 | 63301989 |
Hypercreatininaemia | 13.52 | 9.59 | 12 | 182323 | 559 | 63306128 |
No adverse event | 13.48 | 9.59 | 67 | 182268 | 41338 | 63265349 |
Blood growth hormone increased | 13.43 | 9.59 | 11 | 182324 | 459 | 63306228 |
Sinus pain | 13.38 | 9.59 | 30 | 182305 | 3380 | 63303307 |
Back pain | 13.36 | 9.59 | 905 | 181430 | 263240 | 63043447 |
Mydriasis | 13.29 | 9.59 | 9 | 182326 | 11947 | 63294740 |
Lichen planus | 13.29 | 9.59 | 24 | 182311 | 2314 | 63304373 |
Hyperkalaemia | 13.20 | 9.59 | 224 | 182111 | 53979 | 63252708 |
Hemiparesis | 13.16 | 9.59 | 113 | 182222 | 23169 | 63283518 |
Cytokine release syndrome | 13.14 | 9.59 | 13 | 182322 | 14301 | 63292386 |
Nephrolithiasis | 13.11 | 9.59 | 181 | 182154 | 41803 | 63264884 |
Thrombotic microangiopathy | 13.07 | 9.59 | 7 | 182328 | 10554 | 63296133 |
Erythema marginatum | 13.03 | 9.59 | 4 | 182331 | 16 | 63306671 |
Hypomagnesaemia | 13.00 | 9.59 | 133 | 182202 | 28604 | 63278083 |
Autoimmune myositis | 12.99 | 9.59 | 7 | 182328 | 142 | 63306545 |
Rheumatoid arthritis | 12.99 | 9.59 | 596 | 181739 | 253223 | 63053464 |
Blood ketone body increased | 12.98 | 9.59 | 9 | 182326 | 291 | 63306396 |
Sputum retention | 12.98 | 9.59 | 12 | 182323 | 590 | 63306097 |
Carotid artery occlusion | 12.84 | 9.59 | 36 | 182299 | 4658 | 63302029 |
Polyglandular autoimmune syndrome type II | 12.80 | 9.59 | 5 | 182330 | 46 | 63306641 |
Sleep apnoea syndrome | 12.79 | 9.59 | 134 | 182201 | 28999 | 63277688 |
Eating disorder | 12.77 | 9.59 | 96 | 182239 | 18920 | 63287767 |
Cystitis noninfective | 12.63 | 9.59 | 15 | 182320 | 988 | 63305699 |
Haemorrhagic stroke | 12.62 | 9.59 | 41 | 182294 | 5751 | 63300936 |
Excessive cerumen production | 12.53 | 9.59 | 10 | 182325 | 402 | 63306285 |
Injection site hypersensitivity | 12.53 | 9.59 | 22 | 182313 | 2075 | 63304612 |
Gastrointestinal ulcer perforation | 12.50 | 9.59 | 3 | 182332 | 3 | 63306684 |
Cardiac valve fibroelastoma | 12.50 | 9.59 | 3 | 182332 | 3 | 63306684 |
Diabetic nephropathy | 12.48 | 9.59 | 18 | 182317 | 1436 | 63305251 |
Pulmonary embolism | 12.47 | 9.59 | 248 | 182087 | 116436 | 63190251 |
Low density lipoprotein abnormal | 12.43 | 9.59 | 8 | 182327 | 228 | 63306459 |
Cerebral haemorrhage | 12.40 | 9.59 | 139 | 182196 | 30590 | 63276097 |
Abortion induced | 12.37 | 9.59 | 7 | 182328 | 10235 | 63296452 |
Urticaria | 12.36 | 9.59 | 372 | 181963 | 165430 | 63141257 |
Hyperparathyroidism secondary | 12.35 | 9.59 | 18 | 182317 | 1449 | 63305238 |
Heart rate increased | 12.25 | 9.59 | 356 | 181979 | 93882 | 63212805 |
X-ray abnormal | 12.25 | 9.59 | 4 | 182331 | 8106 | 63298581 |
Cardiac failure chronic | 12.20 | 9.59 | 34 | 182301 | 4384 | 63302303 |
Eyelid oedema | 12.20 | 9.59 | 61 | 182274 | 10418 | 63296269 |
Vitamin B12 decreased | 12.19 | 9.59 | 30 | 182305 | 3590 | 63303097 |
Acute myeloid leukaemia | 12.15 | 9.59 | 19 | 182316 | 17128 | 63289559 |
Urine ketone body present | 12.12 | 9.59 | 24 | 182311 | 2479 | 63304208 |
Aortic valve calcification | 12.12 | 9.59 | 11 | 182324 | 528 | 63306159 |
Dysgeusia | 12.10 | 9.59 | 195 | 182140 | 46515 | 63260172 |
Brain injury | 12.02 | 9.59 | 46 | 182289 | 6997 | 63299690 |
Trimethylaminuria | 12.02 | 9.59 | 7 | 182328 | 166 | 63306521 |
Gamma-glutamyltransferase increased | 12.00 | 9.59 | 150 | 182185 | 33881 | 63272806 |
Croup infectious | 11.98 | 9.59 | 11 | 182324 | 536 | 63306151 |
Oedema peripheral | 11.94 | 9.59 | 662 | 181673 | 188849 | 63117838 |
Complication associated with device | 11.86 | 9.59 | 19 | 182316 | 16959 | 63289728 |
Pulmonary haemorrhage | 11.84 | 9.59 | 3 | 182332 | 7178 | 63299509 |
Bronchopulmonary aspergillosis | 11.79 | 9.59 | 5 | 182330 | 8630 | 63298057 |
Cardiac flutter | 11.79 | 9.59 | 32 | 182303 | 4064 | 63302623 |
Skin discolouration | 11.78 | 9.59 | 163 | 182172 | 37665 | 63269022 |
Pemphigoid | 11.75 | 9.59 | 47 | 182288 | 7297 | 63299390 |
Low birth weight baby | 11.71 | 9.59 | 3 | 182332 | 7126 | 63299561 |
Circulatory collapse | 11.51 | 9.59 | 29 | 182306 | 21909 | 63284778 |
Drug resistance | 11.50 | 9.59 | 31 | 182304 | 22902 | 63283785 |
Type 2 diabetes mellitus | 11.48 | 9.59 | 252 | 182083 | 63616 | 63243071 |
Photosensitivity reaction | 11.40 | 9.59 | 78 | 182257 | 14916 | 63291771 |
Joint dislocation | 11.37 | 9.59 | 23 | 182312 | 18777 | 63287910 |
Drug withdrawal syndrome | 11.34 | 9.59 | 40 | 182295 | 27154 | 63279533 |
Cardiac disorder | 11.30 | 9.59 | 207 | 182128 | 50609 | 63256078 |
Ingrowing nail | 11.29 | 9.59 | 23 | 182312 | 2426 | 63304261 |
Sputum discoloured | 11.25 | 9.59 | 83 | 182252 | 16264 | 63290423 |
Obesity | 11.23 | 9.59 | 46 | 182289 | 29906 | 63276781 |
Skin laceration | 11.20 | 9.59 | 107 | 182228 | 22601 | 63284086 |
Pruritus genital | 11.15 | 9.59 | 24 | 182311 | 2630 | 63304057 |
Giant cell arteritis | 11.14 | 9.59 | 22 | 182313 | 2269 | 63304418 |
Cardiac failure | 11.11 | 9.59 | 335 | 182000 | 88807 | 63217880 |
Peripheral venous disease | 11.11 | 9.59 | 17 | 182318 | 15460 | 63291227 |
Hepatic steatosis | 11.10 | 9.59 | 129 | 182206 | 28640 | 63278047 |
Atrial tachycardia | 11.10 | 9.59 | 32 | 182303 | 4208 | 63302479 |
Urinary casts present | 11.07 | 9.59 | 5 | 182330 | 68 | 63306619 |
Blood triglycerides decreased | 11.07 | 9.59 | 5 | 182330 | 68 | 63306619 |
Cataract operation | 11.07 | 9.59 | 38 | 182297 | 5484 | 63301203 |
Nasal ulcer | 11.05 | 9.59 | 22 | 182313 | 2282 | 63304405 |
Haemoglobin increased | 11.01 | 9.59 | 29 | 182306 | 3617 | 63303070 |
Overdose | 11.01 | 9.59 | 249 | 182086 | 114829 | 63191858 |
Middle insomnia | 10.98 | 9.59 | 68 | 182267 | 12575 | 63294112 |
Campylobacter test positive | 10.95 | 9.59 | 4 | 182331 | 30 | 63306657 |
Adrenal gland cancer | 10.94 | 9.59 | 5 | 182330 | 70 | 63306617 |
Endometrial disorder | 10.91 | 9.59 | 12 | 182323 | 727 | 63305960 |
Mouth injury | 10.86 | 9.59 | 14 | 182321 | 1003 | 63305684 |
Monocyte count decreased | 10.86 | 9.59 | 21 | 182314 | 2132 | 63304555 |
Maternal condition affecting foetus | 10.83 | 9.59 | 7 | 182328 | 201 | 63306486 |
Encephalitis | 10.82 | 9.59 | 6 | 182329 | 8874 | 63297813 |
Peripheral vascular disorder | 10.79 | 9.59 | 40 | 182295 | 5995 | 63300692 |
Micturition disorder | 10.72 | 9.59 | 23 | 182312 | 2515 | 63304172 |
Lymphangiectasia | 10.69 | 9.59 | 5 | 182330 | 74 | 63306613 |
Spinal instability | 10.66 | 9.59 | 6 | 182329 | 133 | 63306554 |
Tendon pain | 10.61 | 9.59 | 27 | 182308 | 3299 | 63303388 |
Gingival pain | 10.57 | 9.59 | 49 | 182286 | 8113 | 63298574 |
Mean cell haemoglobin increased | 10.56 | 9.59 | 25 | 182310 | 2918 | 63303769 |
Haemophagocytic lymphohistiocytosis | 10.53 | 9.59 | 9 | 182326 | 10618 | 63296069 |
Pseudophaeochromocytoma | 10.51 | 9.59 | 5 | 182330 | 77 | 63306610 |
Somnolence | 10.51 | 9.59 | 413 | 181922 | 178272 | 63128415 |
Total bile acids increased | 10.50 | 9.59 | 6 | 182329 | 137 | 63306550 |
Tinnitus | 10.48 | 9.59 | 152 | 182183 | 35476 | 63271211 |
Joint abscess | 10.44 | 9.59 | 9 | 182326 | 403 | 63306284 |
Ventricular fibrillation | 10.41 | 9.59 | 64 | 182271 | 11803 | 63294884 |
Febrile bone marrow aplasia | 10.40 | 9.59 | 4 | 182331 | 7321 | 63299366 |
Lipase increased | 10.39 | 9.59 | 56 | 182279 | 9844 | 63296843 |
Pulseless electrical activity | 10.38 | 9.59 | 46 | 182289 | 7475 | 63299212 |
Vascular pseudoaneurysm | 10.36 | 9.59 | 17 | 182318 | 1517 | 63305170 |
Vaginal odour | 10.35 | 9.59 | 10 | 182325 | 520 | 63306167 |
Inflammation | 10.33 | 9.59 | 170 | 182165 | 82103 | 63224584 |
Peripheral arterial occlusive disease | 10.32 | 9.59 | 31 | 182304 | 4170 | 63302517 |
BRAF V600E mutation positive | 10.32 | 9.59 | 4 | 182331 | 36 | 63306651 |
Neonatal asphyxia | 10.30 | 9.59 | 8 | 182327 | 309 | 63306378 |
Aortic disorder | 10.29 | 9.59 | 12 | 182323 | 775 | 63305912 |
Autoimmune nephritis | 10.26 | 9.59 | 9 | 182326 | 413 | 63306274 |
Coeliac disease | 10.24 | 9.59 | 13 | 182322 | 12784 | 63293903 |
Obstructive pancreatitis | 10.24 | 9.59 | 9 | 182326 | 414 | 63306273 |
Mental disorder | 10.23 | 9.59 | 39 | 182296 | 25880 | 63280807 |
Pollakiuria | 10.22 | 9.59 | 124 | 182211 | 27813 | 63278874 |
Forced vital capacity decreased | 10.21 | 9.59 | 14 | 182321 | 1065 | 63305622 |
Procedural pain | 10.20 | 9.59 | 30 | 182305 | 21539 | 63285148 |
Diverticulitis | 10.19 | 9.59 | 165 | 182170 | 39392 | 63267295 |
Agitation | 10.19 | 9.59 | 116 | 182219 | 59641 | 63247046 |
Tri-iodothyronine free decreased | 10.14 | 9.59 | 8 | 182327 | 316 | 63306371 |
Idiopathic angioedema | 10.13 | 9.59 | 4 | 182331 | 38 | 63306649 |
Blood creatine phosphokinase MM increased | 10.13 | 9.59 | 4 | 182331 | 38 | 63306649 |
Blood cholesterol decreased | 10.09 | 9.59 | 13 | 182322 | 931 | 63305756 |
Nasal discharge discolouration | 10.08 | 9.59 | 21 | 182314 | 2250 | 63304437 |
Atelectasis | 10.07 | 9.59 | 30 | 182305 | 21453 | 63285234 |
Sinus tachycardia | 9.92 | 9.59 | 36 | 182299 | 24232 | 63282455 |
Vascular encephalopathy | 9.92 | 9.59 | 9 | 182326 | 432 | 63306255 |
Carotid artery stenosis | 9.86 | 9.59 | 35 | 182300 | 5135 | 63301552 |
Hepatitis acute | 9.86 | 9.59 | 52 | 182283 | 9068 | 63297619 |
Interstitial granulomatous dermatitis | 9.77 | 9.59 | 4 | 182331 | 42 | 63306645 |
Urea urine increased | 9.77 | 9.59 | 3 | 182332 | 12 | 63306675 |
Gastrointestinal toxicity | 9.77 | 9.59 | 5 | 182330 | 7736 | 63298951 |
Renal tubular necrosis | 9.76 | 9.59 | 63 | 182272 | 11815 | 63294872 |
Hypercalcaemia | 9.70 | 9.59 | 45 | 182290 | 28277 | 63278410 |
Impaired fasting glucose | 9.68 | 9.59 | 7 | 182328 | 242 | 63306445 |
Duplicate therapy error | 9.67 | 9.59 | 5 | 182330 | 93 | 63306594 |
Blood urea increased | 9.61 | 9.59 | 117 | 182218 | 26262 | 63280425 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Myalgia | 1263.02 | 10.74 | 1711 | 154593 | 82399 | 34718228 |
Rhabdomyolysis | 1047.73 | 10.74 | 1403 | 154901 | 66760 | 34733867 |
Blood creatine phosphokinase increased | 507.09 | 10.74 | 799 | 155505 | 44058 | 34756569 |
Toxicity to various agents | 357.31 | 10.74 | 228 | 156076 | 200134 | 34600493 |
Myopathy | 276.06 | 10.74 | 298 | 156006 | 11256 | 34789371 |
Drug abuse | 275.92 | 10.74 | 54 | 156250 | 99042 | 34701585 |
Death | 228.10 | 10.74 | 962 | 155342 | 397087 | 34403540 |
Completed suicide | 205.14 | 10.74 | 91 | 156213 | 98077 | 34702550 |
High density lipoprotein decreased | 189.79 | 10.74 | 141 | 156163 | 3219 | 34797408 |
Low density lipoprotein increased | 169.33 | 10.74 | 148 | 156156 | 4288 | 34796339 |
Low density lipoprotein decreased | 139.71 | 10.74 | 78 | 156226 | 1065 | 34799562 |
Neutropenia | 138.55 | 10.74 | 310 | 155994 | 156468 | 34644159 |
Blood triglycerides increased | 134.00 | 10.74 | 233 | 156071 | 13926 | 34786701 |
Foetal exposure during pregnancy | 132.09 | 10.74 | 10 | 156294 | 38091 | 34762536 |
Rheumatoid factor negative | 131.19 | 10.74 | 69 | 156235 | 830 | 34799797 |
Asthma | 122.10 | 10.74 | 444 | 155860 | 42212 | 34758415 |
Off label use | 119.30 | 10.74 | 1251 | 155053 | 418273 | 34382354 |
Full blood count abnormal | 117.84 | 10.74 | 259 | 156045 | 18409 | 34782218 |
Pyrexia | 117.13 | 10.74 | 941 | 155363 | 332072 | 34468555 |
Angina pectoris | 114.18 | 10.74 | 354 | 155950 | 31009 | 34769618 |
Coronary artery disease | 112.41 | 10.74 | 471 | 155833 | 47834 | 34752793 |
Tendon rupture | 103.89 | 10.74 | 142 | 156162 | 6870 | 34793757 |
Pneumonia | 101.08 | 10.74 | 1086 | 155218 | 361541 | 34439086 |
Chest discomfort | 99.54 | 10.74 | 495 | 155809 | 54035 | 34746592 |
Overdose | 94.22 | 10.74 | 164 | 156140 | 90895 | 34709732 |
Muscle spasms | 90.54 | 10.74 | 610 | 155694 | 74391 | 34726236 |
Myocardial infarction | 89.72 | 10.74 | 881 | 155423 | 120204 | 34680423 |
Disease progression | 89.57 | 10.74 | 221 | 156083 | 107856 | 34692771 |
Sepsis | 89.19 | 10.74 | 412 | 155892 | 166149 | 34634478 |
Intentional overdose | 88.81 | 10.74 | 42 | 156262 | 43632 | 34756995 |
Acute kidney injury | 87.53 | 10.74 | 1878 | 154426 | 303110 | 34497517 |
Mucosal inflammation | 78.75 | 10.74 | 37 | 156267 | 38585 | 34762042 |
Cardiac failure | 77.66 | 10.74 | 684 | 155620 | 90564 | 34710063 |
Coronary artery occlusion | 77.16 | 10.74 | 159 | 156145 | 10803 | 34789824 |
Blood pressure systolic increased | 77.08 | 10.74 | 252 | 156052 | 22700 | 34777927 |
Conjunctivitis allergic | 74.97 | 10.74 | 53 | 156251 | 1117 | 34799510 |
Seizure | 73.81 | 10.74 | 232 | 156072 | 104625 | 34696002 |
Muscular weakness | 73.04 | 10.74 | 567 | 155737 | 72330 | 34728297 |
Chromaturia | 72.65 | 10.74 | 184 | 156120 | 14336 | 34786291 |
Febrile neutropenia | 71.76 | 10.74 | 341 | 155963 | 136508 | 34664119 |
Productive cough | 70.95 | 10.74 | 346 | 155958 | 37467 | 34763160 |
Acute myocardial infarction | 69.73 | 10.74 | 445 | 155859 | 53274 | 34747353 |
Wheezing | 69.38 | 10.74 | 367 | 155937 | 41035 | 34759592 |
Leukopenia | 68.90 | 10.74 | 109 | 156195 | 62747 | 34737880 |
Gait spastic | 68.73 | 10.74 | 49 | 156255 | 1047 | 34799580 |
Multiple organ dysfunction syndrome | 67.05 | 10.74 | 152 | 156152 | 76414 | 34724213 |
Blood cholesterol increased | 66.70 | 10.74 | 223 | 156081 | 20320 | 34780307 |
Pancytopenia | 65.94 | 10.74 | 212 | 156092 | 94945 | 34705682 |
Arthralgia | 65.11 | 10.74 | 1095 | 155209 | 168946 | 34631681 |
Cardiac failure chronic | 64.79 | 10.74 | 122 | 156182 | 7757 | 34792870 |
Rales | 64.51 | 10.74 | 139 | 156165 | 9744 | 34790883 |
Myoglobin blood increased | 63.64 | 10.74 | 73 | 156231 | 2950 | 34797677 |
Ascites | 63.08 | 10.74 | 69 | 156235 | 46502 | 34754125 |
Obstructive airways disorder | 62.14 | 10.74 | 181 | 156123 | 15313 | 34785314 |
Bone erosion | 62.05 | 10.74 | 83 | 156221 | 3932 | 34796695 |
Septic shock | 61.77 | 10.74 | 144 | 156160 | 71690 | 34728937 |
Congenital hiatus hernia | 60.58 | 10.74 | 41 | 156263 | 803 | 34799824 |
Fractional exhaled nitric oxide increased | 60.20 | 10.74 | 45 | 156259 | 1037 | 34799590 |
Mycotic allergy | 59.73 | 10.74 | 36 | 156268 | 572 | 34800055 |
Diastolic dysfunction | 58.30 | 10.74 | 102 | 156202 | 6125 | 34794502 |
Thrombocytopenia | 57.76 | 10.74 | 435 | 155869 | 155812 | 34644815 |
White blood cell count decreased | 57.23 | 10.74 | 226 | 156078 | 95219 | 34705408 |
Computerised tomogram coronary artery abnormal | 57.20 | 10.74 | 25 | 156279 | 192 | 34800435 |
Loss of personal independence in daily activities | 56.89 | 10.74 | 296 | 156008 | 32883 | 34767744 |
Vascular stent stenosis | 56.70 | 10.74 | 45 | 156259 | 1136 | 34799491 |
Spirometry abnormal | 56.38 | 10.74 | 37 | 156267 | 687 | 34799940 |
Erectile dysfunction | 55.84 | 10.74 | 211 | 156093 | 20426 | 34780201 |
Red blood cell sedimentation rate abnormal | 55.17 | 10.74 | 74 | 156230 | 3515 | 34797112 |
Exercise tolerance decreased | 55.10 | 10.74 | 90 | 156214 | 5108 | 34795519 |
Malignant neoplasm progression | 55.03 | 10.74 | 205 | 156099 | 87841 | 34712786 |
Sleep disorder due to a general medical condition | 54.81 | 10.74 | 90 | 156214 | 5131 | 34795496 |
Hypercholesterolaemia | 54.65 | 10.74 | 121 | 156183 | 8641 | 34791986 |
Pain in extremity | 54.51 | 10.74 | 831 | 155473 | 125682 | 34674945 |
Diabetes mellitus | 54.02 | 10.74 | 377 | 155927 | 46496 | 34754131 |
Suicide attempt | 52.93 | 10.74 | 58 | 156246 | 39058 | 34761569 |
Drug dependence | 52.86 | 10.74 | 21 | 156283 | 24196 | 34776431 |
Muscle rupture | 52.66 | 10.74 | 58 | 156246 | 2240 | 34798387 |
Mite allergy | 52.54 | 10.74 | 35 | 156269 | 667 | 34799960 |
Bone marrow failure | 52.38 | 10.74 | 33 | 156271 | 29220 | 34771407 |
Stenosis | 51.95 | 10.74 | 47 | 156257 | 1426 | 34799201 |
Coronary artery stenosis | 51.42 | 10.74 | 125 | 156179 | 9491 | 34791136 |
Blood pressure increased | 51.26 | 10.74 | 611 | 155693 | 87491 | 34713136 |
Cytomegalovirus infection | 50.33 | 10.74 | 27 | 156277 | 26108 | 34774519 |
Hepatojugular reflux | 49.96 | 10.74 | 32 | 156272 | 569 | 34800058 |
Needle fatigue | 49.82 | 10.74 | 37 | 156267 | 844 | 34799783 |
Plantar fasciitis | 49.52 | 10.74 | 54 | 156250 | 2062 | 34798565 |
Arteriosclerosis coronary artery | 49.26 | 10.74 | 145 | 156159 | 12340 | 34788287 |
Angina unstable | 48.54 | 10.74 | 138 | 156166 | 11515 | 34789112 |
Immune-mediated myositis | 48.48 | 10.74 | 53 | 156251 | 2030 | 34798597 |
5-hydroxyindolacetic acid in urine increased | 47.07 | 10.74 | 23 | 156281 | 234 | 34800393 |
Ventricular hypokinesia | 46.94 | 10.74 | 87 | 156217 | 5465 | 34795162 |
Intentional self-injury | 46.65 | 10.74 | 4 | 156300 | 13767 | 34786860 |
Atrial fibrillation | 45.64 | 10.74 | 785 | 155519 | 121608 | 34679019 |
Electrocardiogram Q wave abnormal | 45.18 | 10.74 | 27 | 156277 | 422 | 34800205 |
Ejection fraction decreased | 44.71 | 10.74 | 187 | 156117 | 18967 | 34781660 |
Premature baby | 44.57 | 10.74 | 16 | 156288 | 19617 | 34781010 |
Dust allergy | 44.53 | 10.74 | 35 | 156269 | 871 | 34799756 |
Relapsing-remitting multiple sclerosis | 44.08 | 10.74 | 37 | 156267 | 1013 | 34799614 |
Dyspnoea exertional | 44.08 | 10.74 | 338 | 155966 | 42941 | 34757686 |
Orbital myositis | 43.85 | 10.74 | 18 | 156286 | 116 | 34800511 |
Asthenia | 43.41 | 10.74 | 1418 | 154886 | 243833 | 34556794 |
Ill-defined disorder | 43.40 | 10.74 | 149 | 156155 | 13760 | 34786867 |
Infection | 43.37 | 10.74 | 234 | 156070 | 90681 | 34709946 |
Psychotic disorder | 43.21 | 10.74 | 28 | 156276 | 24424 | 34776203 |
Muscle necrosis | 43.06 | 10.74 | 34 | 156270 | 852 | 34799775 |
Blood mercury abnormal | 43.03 | 10.74 | 21 | 156283 | 213 | 34800414 |
Micturition urgency | 42.85 | 10.74 | 92 | 156212 | 6433 | 34794194 |
Middle insomnia | 42.50 | 10.74 | 94 | 156210 | 6708 | 34793919 |
Drug ineffective | 41.50 | 10.74 | 1647 | 154657 | 455104 | 34345523 |
Euglycaemic diabetic ketoacidosis | 41.45 | 10.74 | 61 | 156243 | 3161 | 34797466 |
Vomiting | 41.23 | 10.74 | 820 | 155484 | 246801 | 34553826 |
Somnolence | 41.20 | 10.74 | 309 | 155995 | 110807 | 34689820 |
Brain natriuretic peptide increased | 40.91 | 10.74 | 83 | 156221 | 5576 | 34795051 |
Chest pain | 40.61 | 10.74 | 794 | 155510 | 125968 | 34674659 |
Acute coronary syndrome | 40.44 | 10.74 | 143 | 156161 | 13402 | 34787225 |
Respiratory failure | 40.22 | 10.74 | 302 | 156002 | 108270 | 34692357 |
Dermatomyositis | 39.59 | 10.74 | 38 | 156266 | 1245 | 34799382 |
Rhinitis perennial | 39.11 | 10.74 | 22 | 156282 | 305 | 34800322 |
Eosinophilia | 38.94 | 10.74 | 225 | 156079 | 25997 | 34774630 |
Arteriosclerosis | 38.92 | 10.74 | 130 | 156174 | 11838 | 34788789 |
Coma | 38.91 | 10.74 | 92 | 156212 | 45586 | 34755041 |
Hepatic enzyme increased | 37.48 | 10.74 | 301 | 156003 | 38779 | 34761848 |
Occult blood | 37.30 | 10.74 | 31 | 156273 | 837 | 34799790 |
Tricuspid valve incompetence | 37.22 | 10.74 | 112 | 156192 | 9648 | 34790979 |
Muscle disorder | 37.21 | 10.74 | 52 | 156252 | 2569 | 34798058 |
Lung diffusion test decreased | 37.19 | 10.74 | 27 | 156277 | 594 | 34800033 |
Amyotrophic lateral sclerosis | 36.93 | 10.74 | 33 | 156271 | 985 | 34799642 |
Gait disturbance | 36.93 | 10.74 | 560 | 155744 | 84580 | 34716047 |
Malignant melanoma in situ | 36.84 | 10.74 | 42 | 156262 | 1686 | 34798941 |
Diabetic ketoacidosis | 36.72 | 10.74 | 169 | 156135 | 17863 | 34782764 |
Drug resistance | 36.69 | 10.74 | 37 | 156267 | 25890 | 34774737 |
Fractured coccyx | 36.49 | 10.74 | 17 | 156287 | 154 | 34800473 |
Diabetes mellitus inadequate control | 35.87 | 10.74 | 137 | 156167 | 13327 | 34787300 |
Reversible airways obstruction | 35.69 | 10.74 | 24 | 156280 | 465 | 34800162 |
Mental status changes | 35.48 | 10.74 | 73 | 156231 | 38010 | 34762617 |
Low cardiac output syndrome | 35.43 | 10.74 | 26 | 156278 | 582 | 34800045 |
Haemorrhagic stroke | 34.96 | 10.74 | 85 | 156219 | 6454 | 34794173 |
Sensation of foreign body | 34.81 | 10.74 | 52 | 156252 | 2731 | 34797896 |
Drug withdrawal syndrome | 34.66 | 10.74 | 23 | 156281 | 19811 | 34780816 |
Product use in unapproved indication | 34.55 | 10.74 | 347 | 155957 | 117152 | 34683475 |
Respiratory distress | 34.40 | 10.74 | 67 | 156237 | 35598 | 34765029 |
Carotid arteriosclerosis | 34.37 | 10.74 | 42 | 156262 | 1816 | 34798811 |
Agitation | 34.33 | 10.74 | 136 | 156168 | 57263 | 34743364 |
Hypertonic bladder | 34.26 | 10.74 | 42 | 156262 | 1822 | 34798805 |
Haemophagocytic lymphohistiocytosis | 34.17 | 10.74 | 8 | 156296 | 12965 | 34787662 |
General physical health deterioration | 34.01 | 10.74 | 388 | 155916 | 127881 | 34672746 |
Dizziness | 34.00 | 10.74 | 1245 | 155059 | 217276 | 34583351 |
Blood pressure inadequately controlled | 33.99 | 10.74 | 50 | 156254 | 2590 | 34798037 |
Glycosylated haemoglobin increased | 33.98 | 10.74 | 120 | 156184 | 11240 | 34789387 |
Myositis | 33.97 | 10.74 | 125 | 156179 | 11945 | 34788682 |
Dyslipidaemia | 33.48 | 10.74 | 91 | 156213 | 7397 | 34793230 |
Helicobacter gastritis | 33.30 | 10.74 | 34 | 156270 | 1202 | 34799425 |
Troponin increased | 32.95 | 10.74 | 119 | 156185 | 11270 | 34789357 |
Encephalopathy | 32.65 | 10.74 | 68 | 156236 | 35251 | 34765376 |
Respiratory depression | 32.44 | 10.74 | 16 | 156288 | 16229 | 34784398 |
Neuroleptic malignant syndrome | 32.43 | 10.74 | 20 | 156284 | 17914 | 34782713 |
Hepatic neoplasm | 32.30 | 10.74 | 42 | 156262 | 1935 | 34798692 |
Muscle discomfort | 32.20 | 10.74 | 14 | 156290 | 106 | 34800521 |
Presyncope | 31.95 | 10.74 | 169 | 156135 | 18890 | 34781737 |
Neutrophil count decreased | 31.25 | 10.74 | 120 | 156184 | 50984 | 34749643 |
Cardio-respiratory arrest | 30.55 | 10.74 | 135 | 156169 | 55138 | 34745489 |
Blood thyroid stimulating hormone abnormal | 30.54 | 10.74 | 20 | 156284 | 370 | 34800257 |
Interstitial lung disease | 30.50 | 10.74 | 435 | 155869 | 64847 | 34735780 |
N-terminal prohormone brain natriuretic peptide abnormal | 30.38 | 10.74 | 16 | 156288 | 193 | 34800434 |
Respiratory arrest | 30.37 | 10.74 | 49 | 156255 | 27994 | 34772633 |
Type 2 diabetes mellitus | 30.27 | 10.74 | 147 | 156157 | 15885 | 34784742 |
Normochromic normocytic anaemia | 29.95 | 10.74 | 62 | 156242 | 4225 | 34796402 |
Neutropenic sepsis | 29.94 | 10.74 | 12 | 156292 | 13755 | 34786872 |
Skin laceration | 29.88 | 10.74 | 123 | 156181 | 12386 | 34788241 |
Carotid artery stenosis | 29.83 | 10.74 | 68 | 156236 | 4951 | 34795676 |
Supine hypertension | 29.56 | 10.74 | 19 | 156285 | 340 | 34800287 |
Bundle branch block left | 29.11 | 10.74 | 75 | 156229 | 5904 | 34794723 |
Discomfort | 29.10 | 10.74 | 164 | 156140 | 18774 | 34781853 |
Pathogen resistance | 28.96 | 10.74 | 4 | 156300 | 9478 | 34791149 |
Mitral valve incompetence | 28.93 | 10.74 | 138 | 156166 | 14805 | 34785822 |
Platelet count decreased | 28.74 | 10.74 | 370 | 155934 | 119347 | 34681280 |
Plasmapheresis | 28.50 | 10.74 | 18 | 156286 | 312 | 34800315 |
Left ventricular dysfunction | 28.47 | 10.74 | 104 | 156200 | 9903 | 34790724 |
Toxic epidermal necrolysis | 28.29 | 10.74 | 33 | 156271 | 21613 | 34779014 |
Product substitution issue | 27.95 | 10.74 | 104 | 156200 | 9991 | 34790636 |
Pericardial disease | 27.94 | 10.74 | 20 | 156284 | 430 | 34800197 |
Depressed level of consciousness | 27.90 | 10.74 | 98 | 156206 | 42743 | 34757884 |
Pulmonary valve disease | 27.86 | 10.74 | 18 | 156286 | 325 | 34800302 |
Candida infection | 27.78 | 10.74 | 23 | 156281 | 17692 | 34782935 |
Dyspnoea | 27.62 | 10.74 | 1997 | 154307 | 374785 | 34425842 |
Aggression | 27.53 | 10.74 | 86 | 156218 | 38878 | 34761749 |
Guillain-Barre syndrome | 27.24 | 10.74 | 74 | 156230 | 6013 | 34794614 |
Thrombotic microangiopathy | 27.13 | 10.74 | 7 | 156297 | 10623 | 34790004 |
Hyperthyroidism | 26.92 | 10.74 | 106 | 156198 | 10460 | 34790167 |
Staphylococcal infection | 26.32 | 10.74 | 68 | 156236 | 32692 | 34767935 |
Poisoning | 26.04 | 10.74 | 11 | 156293 | 12215 | 34788412 |
Nipple inflammation | 25.98 | 10.74 | 10 | 156294 | 53 | 34800574 |
Left ventricular enlargement | 25.95 | 10.74 | 23 | 156281 | 679 | 34799948 |
Lipoprotein (a) increased | 25.82 | 10.74 | 10 | 156294 | 54 | 34800573 |
Abnormal behaviour | 25.77 | 10.74 | 45 | 156259 | 24924 | 34775703 |
Tumour lysis syndrome | 25.71 | 10.74 | 23 | 156281 | 17036 | 34783591 |
Cough | 25.45 | 10.74 | 864 | 155440 | 149276 | 34651351 |
Coronary artery restenosis | 25.27 | 10.74 | 27 | 156277 | 1007 | 34799620 |
Device related infection | 25.08 | 10.74 | 24 | 156280 | 17213 | 34783414 |
Cardiac arrest | 25.04 | 10.74 | 292 | 156012 | 95867 | 34704760 |
Low density lipoprotein abnormal | 24.99 | 10.74 | 17 | 156287 | 336 | 34800291 |
Neoplasm progression | 24.96 | 10.74 | 41 | 156263 | 23259 | 34777368 |
Miosis | 24.87 | 10.74 | 6 | 156298 | 9529 | 34791098 |
Inspiratory capacity abnormal | 24.74 | 10.74 | 12 | 156292 | 120 | 34800507 |
Posterior reversible encephalopathy syndrome | 24.56 | 10.74 | 7 | 156297 | 9947 | 34790680 |
Blood glucose increased | 24.50 | 10.74 | 427 | 155877 | 66291 | 34734336 |
Blood pressure fluctuation | 24.49 | 10.74 | 195 | 156109 | 25054 | 34775573 |
Crush syndrome | 24.42 | 10.74 | 10 | 156294 | 64 | 34800563 |
Cardiac discomfort | 24.41 | 10.74 | 21 | 156283 | 595 | 34800032 |
Breast pain | 24.37 | 10.74 | 31 | 156273 | 1397 | 34799230 |
Anaemia | 24.31 | 10.74 | 827 | 155477 | 232508 | 34568119 |
Brain natriuretic peptide abnormal | 24.26 | 10.74 | 17 | 156287 | 353 | 34800274 |
Pancreatitis | 24.06 | 10.74 | 273 | 156031 | 38618 | 34762009 |
Musculoskeletal discomfort | 23.93 | 10.74 | 85 | 156219 | 7983 | 34792644 |
Autoimmune myositis | 23.91 | 10.74 | 12 | 156292 | 130 | 34800497 |
Immune reconstitution inflammatory syndrome | 23.88 | 10.74 | 5 | 156299 | 8754 | 34791873 |
Autoimmune hepatitis | 23.65 | 10.74 | 57 | 156247 | 4303 | 34796324 |
Nodular rash | 23.58 | 10.74 | 11 | 156293 | 100 | 34800527 |
Hospitalisation | 23.14 | 10.74 | 154 | 156150 | 56748 | 34743879 |
Transient ischaemic attack | 22.94 | 10.74 | 206 | 156098 | 27407 | 34773220 |
Blood cholesterol decreased | 22.92 | 10.74 | 26 | 156278 | 1038 | 34799589 |
Growth hormone deficiency | 22.83 | 10.74 | 15 | 156289 | 279 | 34800348 |
Stomatitis | 22.79 | 10.74 | 105 | 156199 | 42409 | 34758218 |
Chronic kidney disease | 22.72 | 10.74 | 283 | 156021 | 40927 | 34759700 |
Monoparesis | 22.71 | 10.74 | 39 | 156265 | 2307 | 34798320 |
Lipoma | 22.67 | 10.74 | 33 | 156271 | 1693 | 34798934 |
Head titubation | 22.66 | 10.74 | 17 | 156287 | 394 | 34800233 |
Breath sounds abnormal | 22.60 | 10.74 | 75 | 156229 | 6806 | 34793821 |
Ventricular extrasystoles | 22.60 | 10.74 | 110 | 156194 | 11898 | 34788729 |
Aortic aneurysm | 22.37 | 10.74 | 74 | 156230 | 6705 | 34793922 |
Acute respiratory distress syndrome | 22.36 | 10.74 | 52 | 156252 | 25917 | 34774710 |
Bronchiectasis | 22.33 | 10.74 | 95 | 156209 | 9706 | 34790921 |
Hepatitis C | 22.33 | 10.74 | 8 | 156296 | 9822 | 34790805 |
Melanoderma | 22.21 | 10.74 | 12 | 156292 | 153 | 34800474 |
Enterococcal infection | 22.14 | 10.74 | 7 | 156297 | 9299 | 34791328 |
Pollakiuria | 21.93 | 10.74 | 157 | 156147 | 19517 | 34781110 |
Hepatic encephalopathy | 21.89 | 10.74 | 20 | 156284 | 14665 | 34785962 |
Blood triglycerides abnormal | 21.85 | 10.74 | 14 | 156290 | 249 | 34800378 |
Bronchopulmonary aspergillosis | 21.81 | 10.74 | 20 | 156284 | 14639 | 34785988 |
Meningitis aseptic | 21.79 | 10.74 | 46 | 156258 | 3178 | 34797449 |
Seronegative arthritis | 21.72 | 10.74 | 25 | 156279 | 1014 | 34799613 |
Pulmonary arterial pressure abnormal | 21.71 | 10.74 | 13 | 156291 | 204 | 34800423 |
Physical examination abnormal | 21.68 | 10.74 | 15 | 156289 | 305 | 34800322 |
Total cholesterol/HDL ratio increased | 21.61 | 10.74 | 12 | 156292 | 162 | 34800465 |
Substance abuse | 21.59 | 10.74 | 4 | 156300 | 7637 | 34792990 |
Body temperature decreased | 21.45 | 10.74 | 115 | 156189 | 12919 | 34787708 |
Fatigue | 21.38 | 10.74 | 1929 | 154375 | 368724 | 34431903 |
Loss of control of legs | 21.29 | 10.74 | 21 | 156283 | 712 | 34799915 |
Cytokine release syndrome | 21.18 | 10.74 | 44 | 156260 | 22833 | 34777794 |
Muscle spasticity | 20.99 | 10.74 | 66 | 156238 | 5822 | 34794805 |
Pulmonary function test abnormal | 20.95 | 10.74 | 40 | 156264 | 2570 | 34798057 |
Chronic obstructive pulmonary disease | 20.90 | 10.74 | 321 | 155983 | 48597 | 34752030 |
Colitis ulcerative | 20.89 | 10.74 | 136 | 156168 | 16384 | 34784243 |
Pneumocystis jirovecii pneumonia | 20.82 | 10.74 | 35 | 156269 | 19675 | 34780952 |
Diabetic neuropathy | 20.80 | 10.74 | 53 | 156251 | 4144 | 34796483 |
Cytomegalovirus viraemia | 20.76 | 10.74 | 4 | 156300 | 7426 | 34793201 |
Inappropriate antidiuretic hormone secretion | 20.69 | 10.74 | 16 | 156288 | 12737 | 34787890 |
Diabetic metabolic decompensation | 20.68 | 10.74 | 32 | 156272 | 1734 | 34798893 |
Atrial septal defect | 20.61 | 10.74 | 4 | 156300 | 7388 | 34793239 |
Carcinoid tumour | 20.60 | 10.74 | 13 | 156291 | 225 | 34800402 |
Chronic cutaneous lupus erythematosus | 20.53 | 10.74 | 10 | 156294 | 101 | 34800526 |
No adverse event | 20.48 | 10.74 | 45 | 156259 | 22882 | 34777745 |
Muscle injury | 20.42 | 10.74 | 29 | 156275 | 1454 | 34799173 |
Oesophageal carcinoma | 20.42 | 10.74 | 8 | 156296 | 9296 | 34791331 |
Intentional product misuse | 20.32 | 10.74 | 120 | 156184 | 45491 | 34755136 |
Haematocrit increased | 20.28 | 10.74 | 35 | 156269 | 2078 | 34798549 |
Aplastic anaemia | 20.28 | 10.74 | 9 | 156295 | 9707 | 34790920 |
Glomerular filtration rate | 20.19 | 10.74 | 10 | 156294 | 105 | 34800522 |
Blood cholesterol abnormal | 20.14 | 10.74 | 32 | 156272 | 1774 | 34798853 |
Movement disorder | 20.12 | 10.74 | 108 | 156196 | 12140 | 34788487 |
Incorrect route of product administration | 20.09 | 10.74 | 22 | 156282 | 14823 | 34785804 |
Haematuria | 20.05 | 10.74 | 325 | 155979 | 49741 | 34750886 |
Food aversion | 19.86 | 10.74 | 16 | 156288 | 413 | 34800214 |
N-terminal prohormone brain natriuretic peptide increased | 19.84 | 10.74 | 40 | 156264 | 2675 | 34797952 |
Anastomotic infection | 19.71 | 10.74 | 10 | 156294 | 111 | 34800516 |
Dysphagia | 19.68 | 10.74 | 181 | 156123 | 62200 | 34738427 |
Lipids increased | 19.67 | 10.74 | 24 | 156280 | 1036 | 34799591 |
Aortic stenosis | 19.52 | 10.74 | 53 | 156251 | 4305 | 34796322 |
Akathisia | 19.47 | 10.74 | 6 | 156298 | 8103 | 34792524 |
Right atrial enlargement | 19.41 | 10.74 | 13 | 156291 | 250 | 34800377 |
Polymyositis | 19.40 | 10.74 | 28 | 156276 | 1425 | 34799202 |
Transplant rejection | 19.35 | 10.74 | 11 | 156293 | 10300 | 34790327 |
Ventricular hyperkinesia | 19.20 | 10.74 | 12 | 156292 | 204 | 34800423 |
Transaminases abnormal | 19.19 | 10.74 | 13 | 156291 | 255 | 34800372 |
Aortic valve incompetence | 19.08 | 10.74 | 64 | 156240 | 5840 | 34794787 |
Secretion discharge | 19.07 | 10.74 | 64 | 156240 | 5841 | 34794786 |
Drug interaction | 19.05 | 10.74 | 1212 | 155092 | 224734 | 34575893 |
Palpitations | 18.89 | 10.74 | 267 | 156037 | 39719 | 34760908 |
Mitral valve thickening | 18.89 | 10.74 | 15 | 156289 | 379 | 34800248 |
Mean platelet volume increased | 18.87 | 10.74 | 17 | 156287 | 513 | 34800114 |
Ventricular arrhythmia | 18.83 | 10.74 | 61 | 156243 | 5467 | 34795160 |
Adjustment disorder | 18.82 | 10.74 | 25 | 156279 | 1176 | 34799451 |
Prinzmetal angina | 18.79 | 10.74 | 23 | 156281 | 996 | 34799631 |
Dyspnoea at rest | 18.62 | 10.74 | 48 | 156256 | 3780 | 34796847 |
Drug-induced liver injury | 18.56 | 10.74 | 204 | 156100 | 28628 | 34771999 |
Withdrawal syndrome | 18.52 | 10.74 | 17 | 156287 | 12438 | 34788189 |
Therapy non-responder | 18.52 | 10.74 | 101 | 156203 | 39045 | 34761582 |
Meningitis eosinophilic | 18.50 | 10.74 | 6 | 156298 | 17 | 34800610 |
Cerebral haemorrhage | 18.44 | 10.74 | 238 | 156066 | 34699 | 34765928 |
Product use issue | 18.43 | 10.74 | 187 | 156117 | 63029 | 34737598 |
Electrocardiogram abnormal | 18.34 | 10.74 | 86 | 156218 | 9161 | 34791466 |
Blood thyroid stimulating hormone increased | 18.32 | 10.74 | 51 | 156253 | 4204 | 34796423 |
Musculoskeletal stiffness | 18.32 | 10.74 | 302 | 156002 | 46378 | 34754249 |
Peritonitis | 18.28 | 10.74 | 28 | 156276 | 16337 | 34784290 |
Platelet distribution width increased | 18.07 | 10.74 | 10 | 156294 | 134 | 34800493 |
Mania | 18.06 | 10.74 | 10 | 156294 | 9501 | 34791126 |
Unresponsive to stimuli | 17.99 | 10.74 | 63 | 156241 | 27506 | 34773121 |
Oxygen saturation increased | 17.99 | 10.74 | 13 | 156291 | 284 | 34800343 |
Mycobacterium test positive | 17.98 | 10.74 | 15 | 156289 | 407 | 34800220 |
Pulmonary haemorrhage | 17.93 | 10.74 | 12 | 156292 | 10292 | 34790335 |
Delusion | 17.91 | 10.74 | 18 | 156286 | 12617 | 34788010 |
Left ventricular hypertrophy | 17.91 | 10.74 | 78 | 156226 | 8052 | 34792575 |
Hyponatraemia | 17.88 | 10.74 | 261 | 156043 | 82430 | 34718197 |
Psoriasis | 17.87 | 10.74 | 258 | 156046 | 38554 | 34762073 |
Haemolysis | 17.69 | 10.74 | 7 | 156297 | 8087 | 34792540 |
Degenerative bone disease | 17.61 | 10.74 | 8 | 156296 | 68 | 34800559 |
Oropharyngeal discomfort | 17.57 | 10.74 | 42 | 156262 | 3154 | 34797473 |
Systolic dysfunction | 17.57 | 10.74 | 38 | 156266 | 2670 | 34797957 |
Decreased ventricular preload | 17.56 | 10.74 | 6 | 156298 | 21 | 34800606 |
Electrocardiogram QRS complex abnormal | 17.49 | 10.74 | 14 | 156290 | 358 | 34800269 |
Hepatic function abnormal | 17.40 | 10.74 | 287 | 156017 | 44076 | 34756551 |
Muscle rigidity | 17.32 | 10.74 | 13 | 156291 | 10505 | 34790122 |
Body temperature increased | 17.29 | 10.74 | 32 | 156272 | 17336 | 34783291 |
Cardiac disorder | 17.29 | 10.74 | 280 | 156024 | 42846 | 34757781 |
Paraesthesia | 17.28 | 10.74 | 392 | 155912 | 63780 | 34736847 |
Atrial enlargement | 17.23 | 10.74 | 18 | 156286 | 654 | 34799973 |
Lymphomatoid papulosis | 17.20 | 10.74 | 11 | 156293 | 195 | 34800432 |
Serotonin syndrome | 17.09 | 10.74 | 40 | 156264 | 19893 | 34780734 |
Hypochromasia | 17.08 | 10.74 | 13 | 156291 | 308 | 34800319 |
Muscle atrophy | 17.05 | 10.74 | 72 | 156232 | 7332 | 34793295 |
Myelosuppression | 17.05 | 10.74 | 38 | 156266 | 19227 | 34781400 |
Nipple disorder | 17.01 | 10.74 | 11 | 156293 | 199 | 34800428 |
Impaired quality of life | 17.00 | 10.74 | 61 | 156243 | 5757 | 34794870 |
Plasma cell myeloma | 16.98 | 10.74 | 114 | 156190 | 41923 | 34758704 |
Gynaecomastia | 16.88 | 10.74 | 90 | 156214 | 10090 | 34790537 |
Haemoglobin increased | 16.84 | 10.74 | 43 | 156261 | 3366 | 34797261 |
Tachycardia | 16.82 | 10.74 | 272 | 156032 | 84500 | 34716127 |
Poisoning deliberate | 16.80 | 10.74 | 7 | 156297 | 7837 | 34792790 |
Coagulopathy | 16.73 | 10.74 | 40 | 156264 | 19749 | 34780878 |
Vascular stent thrombosis | 16.60 | 10.74 | 39 | 156265 | 2896 | 34797731 |
Sedation | 16.57 | 10.74 | 44 | 156260 | 20962 | 34779665 |
Blood pressure diastolic abnormal | 16.26 | 10.74 | 53 | 156251 | 4765 | 34795862 |
Pneumonia aspiration | 16.25 | 10.74 | 115 | 156189 | 41788 | 34758839 |
Progressive multifocal leukoencephalopathy | 16.16 | 10.74 | 12 | 156292 | 9752 | 34790875 |
Pruritus | 16.15 | 10.74 | 783 | 155521 | 141198 | 34659429 |
Osteonecrosis of jaw | 16.07 | 10.74 | 35 | 156269 | 17854 | 34782773 |
Sinus pain | 16.06 | 10.74 | 18 | 156286 | 709 | 34799918 |
Histamine level increased | 15.99 | 10.74 | 7 | 156297 | 54 | 34800573 |
Cytopenia | 15.99 | 10.74 | 20 | 156284 | 12703 | 34787924 |
Cardiotoxicity | 15.87 | 10.74 | 3 | 156301 | 5645 | 34794982 |
Intermittent claudication | 15.82 | 10.74 | 33 | 156271 | 2261 | 34798366 |
Acute hepatic failure | 15.80 | 10.74 | 24 | 156280 | 14050 | 34786577 |
Cerebral infarction | 15.77 | 10.74 | 190 | 156114 | 27265 | 34773362 |
Paraplegia | 15.73 | 10.74 | 38 | 156266 | 2873 | 34797754 |
Walking disability | 15.69 | 10.74 | 20 | 156284 | 903 | 34799724 |
Status epilepticus | 15.67 | 10.74 | 20 | 156284 | 12594 | 34788033 |
Ischaemic stroke | 15.60 | 10.74 | 137 | 156167 | 18113 | 34782514 |
Low birth weight baby | 15.46 | 10.74 | 8 | 156296 | 7897 | 34792730 |
Arterial spasm | 15.37 | 10.74 | 8 | 156296 | 94 | 34800533 |
Nervous system disorder | 15.20 | 10.74 | 26 | 156278 | 14517 | 34786110 |
Syncope | 15.15 | 10.74 | 525 | 155779 | 90926 | 34709701 |
Cardiovascular somatic symptom disorder | 15.11 | 10.74 | 6 | 156298 | 35 | 34800592 |
Forced vital capacity decreased | 15.10 | 10.74 | 18 | 156286 | 758 | 34799869 |
Helicobacter test false negative | 15.07 | 10.74 | 7 | 156297 | 63 | 34800564 |
Mucormycosis | 15.00 | 10.74 | 4 | 156300 | 5938 | 34794689 |
Joint destruction | 14.98 | 10.74 | 13 | 156291 | 373 | 34800254 |
AST/ALT ratio abnormal | 14.97 | 10.74 | 5 | 156299 | 16 | 34800611 |
Angiocardiogram | 14.95 | 10.74 | 10 | 156294 | 192 | 34800435 |
Drug ineffective for unapproved indication | 14.94 | 10.74 | 55 | 156249 | 23660 | 34776967 |
Aldolase increased | 14.88 | 10.74 | 7 | 156297 | 65 | 34800562 |
Aspergillus infection | 14.64 | 10.74 | 20 | 156284 | 12234 | 34788393 |
Hepatitis E antibody positive | 14.62 | 10.74 | 11 | 156293 | 256 | 34800371 |
Prostatic haemorrhage | 14.62 | 10.74 | 11 | 156293 | 256 | 34800371 |
Retroperitoneal fibrosis | 14.52 | 10.74 | 13 | 156291 | 389 | 34800238 |
Dysphonia | 14.39 | 10.74 | 164 | 156140 | 23219 | 34777408 |
Blood creatine phosphokinase | 14.34 | 10.74 | 8 | 156296 | 109 | 34800518 |
Very low density lipoprotein increased | 14.32 | 10.74 | 5 | 156299 | 19 | 34800608 |
Ureteric cancer | 14.30 | 10.74 | 10 | 156294 | 207 | 34800420 |
Bacteraemia | 14.30 | 10.74 | 43 | 156261 | 19674 | 34780953 |
Pancreatitis acute | 14.14 | 10.74 | 190 | 156114 | 27951 | 34772676 |
Blood pressure diastolic increased | 14.11 | 10.74 | 52 | 156252 | 4973 | 34795654 |
Base excess decreased | 14.09 | 10.74 | 10 | 156294 | 212 | 34800415 |
Supraventricular extrasystoles | 14.08 | 10.74 | 41 | 156263 | 3467 | 34797160 |
Sclerodactylia | 14.08 | 10.74 | 6 | 156298 | 43 | 34800584 |
Condition aggravated | 14.07 | 10.74 | 709 | 155595 | 191487 | 34609140 |
Bacterial infection | 14.03 | 10.74 | 35 | 156269 | 17028 | 34783599 |
Cystitis haemorrhagic | 14.00 | 10.74 | 4 | 156300 | 5675 | 34794952 |
Haemoglobin decreased | 14.00 | 10.74 | 422 | 155882 | 120350 | 34680277 |
Tongue oedema | 13.98 | 10.74 | 37 | 156267 | 2960 | 34797667 |
Hemiplegia | 13.94 | 10.74 | 65 | 156239 | 6907 | 34793720 |
Prohormone brain natriuretic peptide increased | 13.93 | 10.74 | 7 | 156297 | 76 | 34800551 |
Blood pressure systolic abnormal | 13.84 | 10.74 | 44 | 156260 | 3904 | 34796723 |
Escherichia infection | 13.82 | 10.74 | 10 | 156294 | 8235 | 34792392 |
Weight decreased | 13.82 | 10.74 | 940 | 155364 | 175361 | 34625266 |
Extrasystoles | 13.76 | 10.74 | 43 | 156261 | 3780 | 34796847 |
Impatience | 13.72 | 10.74 | 12 | 156292 | 348 | 34800279 |
Hallucination, auditory | 13.69 | 10.74 | 20 | 156284 | 11897 | 34788730 |
Gastrooesophageal reflux disease | 13.66 | 10.74 | 242 | 156062 | 37682 | 34762945 |
Diabetic foot | 13.60 | 10.74 | 35 | 156269 | 2753 | 34797874 |
Obsessive-compulsive disorder | 13.57 | 10.74 | 4 | 156300 | 5560 | 34795067 |
Lethargy | 13.55 | 10.74 | 118 | 156186 | 41004 | 34759623 |
Hepatitis E virus test positive | 13.52 | 10.74 | 11 | 156293 | 288 | 34800339 |
Oedema genital | 13.46 | 10.74 | 14 | 156290 | 506 | 34800121 |
Neutrophil count increased | 13.46 | 10.74 | 36 | 156268 | 17110 | 34783517 |
Epilepsy | 13.44 | 10.74 | 50 | 156254 | 21445 | 34779182 |
Ileus | 13.44 | 10.74 | 34 | 156270 | 16465 | 34784162 |
Impaired work ability | 13.41 | 10.74 | 64 | 156240 | 6866 | 34793761 |
Tongue dry | 13.39 | 10.74 | 10 | 156294 | 230 | 34800397 |
Expired product administered | 13.37 | 10.74 | 39 | 156265 | 3302 | 34797325 |
Exostosis | 13.36 | 10.74 | 49 | 156255 | 4674 | 34795953 |
Carnitine palmitoyltransferase deficiency | 13.30 | 10.74 | 4 | 156300 | 8 | 34800619 |
Mesenteric artery thrombosis | 13.29 | 10.74 | 13 | 156291 | 436 | 34800191 |
Fistula | 13.26 | 10.74 | 7 | 156297 | 6833 | 34793794 |
Stevens-Johnson syndrome | 13.26 | 10.74 | 41 | 156263 | 18598 | 34782029 |
Oral candidiasis | 13.26 | 10.74 | 21 | 156283 | 12089 | 34788538 |
Blood triglycerides | 13.24 | 10.74 | 3 | 156301 | 0 | 34800627 |
Joint swelling | 13.18 | 10.74 | 356 | 155948 | 59534 | 34741093 |
Hallucination | 13.15 | 10.74 | 157 | 156147 | 51341 | 34749286 |
High density lipoprotein abnormal | 13.11 | 10.74 | 6 | 156298 | 52 | 34800575 |
Therapeutic product effect incomplete | 13.06 | 10.74 | 307 | 155997 | 50234 | 34750393 |
Heart rate decreased | 13.06 | 10.74 | 207 | 156097 | 31538 | 34769089 |
Malnutrition | 13.03 | 10.74 | 23 | 156281 | 12686 | 34787941 |
Behaviour disorder | 12.98 | 10.74 | 3 | 156301 | 4907 | 34795720 |
Musculoskeletal toxicity | 12.96 | 10.74 | 8 | 156296 | 133 | 34800494 |
Electrocardiogram QRS complex prolonged | 12.92 | 10.74 | 3 | 156301 | 4891 | 34795736 |
Treatment failure | 12.85 | 10.74 | 140 | 156164 | 46557 | 34754070 |
Lipase increased | 12.83 | 10.74 | 79 | 156225 | 9337 | 34791290 |
Hypertension | 12.81 | 10.74 | 739 | 155565 | 135704 | 34664923 |
Drug intolerance | 12.80 | 10.74 | 353 | 155951 | 59217 | 34741410 |
Generalised tonic-clonic seizure | 12.76 | 10.74 | 50 | 156254 | 21124 | 34779503 |
Kidney transplant rejection | 12.69 | 10.74 | 9 | 156295 | 7488 | 34793139 |
Oxygen consumption decreased | 12.65 | 10.74 | 10 | 156294 | 251 | 34800376 |
Eczema | 12.59 | 10.74 | 132 | 156172 | 18304 | 34782323 |
Neuropathy peripheral | 12.55 | 10.74 | 280 | 156024 | 82983 | 34717644 |
Skin toxicity | 12.50 | 10.74 | 3 | 156301 | 4781 | 34795846 |
Appendicitis | 12.46 | 10.74 | 30 | 156274 | 14777 | 34785850 |
Blood pressure ambulatory increased | 12.37 | 10.74 | 6 | 156298 | 60 | 34800567 |
Lipids abnormal | 12.33 | 10.74 | 12 | 156292 | 400 | 34800227 |
Peripheral swelling | 12.33 | 10.74 | 438 | 155866 | 76103 | 34724524 |
Hypogammaglobulinaemia | 12.20 | 10.74 | 10 | 156294 | 7730 | 34792897 |
Stent placement | 12.18 | 10.74 | 50 | 156254 | 5028 | 34795599 |
Heliotrope rash | 12.17 | 10.74 | 4 | 156300 | 12 | 34800615 |
Cardiac autonomic neuropathy | 12.12 | 10.74 | 6 | 156298 | 63 | 34800564 |
Left ventricular dilatation | 12.07 | 10.74 | 16 | 156288 | 751 | 34799876 |
Albuminuria | 12.06 | 10.74 | 12 | 156292 | 411 | 34800216 |
Myocardial ischaemia | 12.06 | 10.74 | 125 | 156179 | 17283 | 34783344 |
Dyspepsia | 12.05 | 10.74 | 231 | 156073 | 36501 | 34764126 |
Tendonitis | 12.02 | 10.74 | 76 | 156228 | 9064 | 34791563 |
Acute respiratory failure | 11.93 | 10.74 | 85 | 156219 | 30843 | 34769784 |
Eosinophilic granulomatosis with polyangiitis | 11.90 | 10.74 | 27 | 156277 | 1960 | 34798667 |
Steroid dependence | 11.87 | 10.74 | 23 | 156281 | 1494 | 34799133 |
Epstein-Barr virus infection | 11.84 | 10.74 | 10 | 156294 | 7618 | 34793009 |
Nodule | 11.80 | 10.74 | 61 | 156243 | 6758 | 34793869 |
Myoglobinuria | 11.73 | 10.74 | 16 | 156288 | 772 | 34799855 |
Glomerular filtration rate increased | 11.64 | 10.74 | 12 | 156292 | 429 | 34800198 |
Infusion related reaction | 11.62 | 10.74 | 167 | 156137 | 52890 | 34747737 |
Angiogram | 11.62 | 10.74 | 9 | 156295 | 219 | 34800408 |
Hypoaesthesia | 11.53 | 10.74 | 358 | 155946 | 61086 | 34739541 |
Abscess of salivary gland | 11.49 | 10.74 | 4 | 156300 | 15 | 34800612 |
Emotional distress | 11.46 | 10.74 | 32 | 156272 | 14994 | 34785633 |
Left atrial enlargement | 11.45 | 10.74 | 17 | 156287 | 888 | 34799739 |
Defect conduction intraventricular | 11.44 | 10.74 | 11 | 156293 | 361 | 34800266 |
Conjunctivitis | 11.43 | 10.74 | 16 | 156288 | 9689 | 34790938 |
Streptococcal infection | 11.33 | 10.74 | 4 | 156300 | 4957 | 34795670 |
Chemical burns of eye | 11.29 | 10.74 | 4 | 156300 | 16 | 34800611 |
High density lipoprotein increased | 11.27 | 10.74 | 11 | 156293 | 368 | 34800259 |
Blood creatinine increased | 11.26 | 10.74 | 526 | 155778 | 94450 | 34706177 |
Pericardial fibrosis | 11.25 | 10.74 | 7 | 156297 | 118 | 34800509 |
Blood urine present | 11.24 | 10.74 | 85 | 156219 | 10749 | 34789878 |
Palmar-plantar erythrodysaesthesia syndrome | 11.22 | 10.74 | 38 | 156266 | 16757 | 34783870 |
Gait inability | 11.20 | 10.74 | 142 | 156162 | 20616 | 34780011 |
Peripheral arterial occlusive disease | 11.19 | 10.74 | 54 | 156250 | 5820 | 34794807 |
Mandibular mass | 11.18 | 10.74 | 3 | 156301 | 3 | 34800624 |
Hepatocellular injury | 11.18 | 10.74 | 150 | 156154 | 22061 | 34778566 |
Klebsiella infection | 11.15 | 10.74 | 13 | 156291 | 8518 | 34792109 |
Eosinophil count increased | 11.10 | 10.74 | 71 | 156233 | 8501 | 34792126 |
Acute myeloid leukaemia | 11.10 | 10.74 | 43 | 156261 | 18227 | 34782400 |
Parkinsonism | 11.08 | 10.74 | 12 | 156292 | 8126 | 34792501 |
Oedema peripheral | 11.06 | 10.74 | 648 | 155656 | 119164 | 34681463 |
Bradycardia | 11.04 | 10.74 | 427 | 155877 | 74991 | 34725636 |
Throat irritation | 10.96 | 10.74 | 83 | 156221 | 10502 | 34790125 |
Hypercreatinaemia | 10.94 | 10.74 | 8 | 156296 | 178 | 34800449 |
Product residue present | 10.93 | 10.74 | 32 | 156272 | 2714 | 34797913 |
Blood chloride increased | 10.93 | 10.74 | 33 | 156271 | 2848 | 34797779 |
Device dislocation | 10.88 | 10.74 | 56 | 156248 | 6193 | 34794434 |
Liver injury | 10.86 | 10.74 | 108 | 156196 | 14770 | 34785857 |
Anaemia macrocytic | 10.86 | 10.74 | 34 | 156270 | 2992 | 34797635 |
Hypoalbuminaemia | 10.78 | 10.74 | 24 | 156280 | 12150 | 34788477 |
Mobility decreased | 10.76 | 10.74 | 192 | 156112 | 29936 | 34770691 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Rhabdomyolysis | 2034.66 | 9.81 | 2171 | 285748 | 100960 | 79355509 |
Myalgia | 1752.09 | 9.81 | 2709 | 285210 | 182932 | 79273537 |
Blood creatine phosphokinase increased | 842.45 | 9.81 | 1114 | 286805 | 64976 | 79391493 |
Myopathy | 449.84 | 9.81 | 458 | 287461 | 20105 | 79436364 |
Maternal exposure during pregnancy | 390.85 | 9.81 | 26 | 287893 | 136512 | 79319957 |
Sedation complication | 362.94 | 9.81 | 360 | 287559 | 15309 | 79441160 |
Creatinine renal clearance decreased | 353.04 | 9.81 | 388 | 287531 | 18614 | 79437855 |
Completed suicide | 348.92 | 9.81 | 229 | 287690 | 245538 | 79210931 |
Orthostatic hypotension | 297.54 | 9.81 | 639 | 287280 | 55525 | 79400944 |
Drug abuse | 286.89 | 9.81 | 114 | 287805 | 162577 | 79293892 |
Acute kidney injury | 274.36 | 9.81 | 2973 | 284946 | 516431 | 78940038 |
Pemphigus | 260.26 | 9.81 | 28 | 287891 | 99554 | 79356915 |
Hand deformity | 248.11 | 9.81 | 39 | 287880 | 103880 | 79352589 |
Low density lipoprotein increased | 241.39 | 9.81 | 220 | 287699 | 8402 | 79448067 |
Glossodynia | 239.56 | 9.81 | 42 | 287877 | 103295 | 79353174 |
Anti-cyclic citrullinated peptide antibody positive | 234.52 | 9.81 | 17 | 287902 | 83126 | 79373343 |
Full blood count abnormal | 233.62 | 9.81 | 477 | 287442 | 39997 | 79416472 |
Angina pectoris | 229.92 | 9.81 | 549 | 287370 | 51183 | 79405286 |
Systemic lupus erythematosus | 226.88 | 9.81 | 77 | 287842 | 121072 | 79335397 |
Exposure during pregnancy | 224.02 | 9.81 | 46 | 287873 | 101086 | 79355383 |
Toxicity to various agents | 214.88 | 9.81 | 790 | 287129 | 420750 | 79035719 |
Synovitis | 211.73 | 9.81 | 142 | 287777 | 150592 | 79305877 |
Blood calcium decreased | 201.69 | 9.81 | 390 | 287529 | 31429 | 79425040 |
Balance disorder | 200.51 | 9.81 | 797 | 287122 | 98060 | 79358409 |
Off label use | 192.40 | 9.81 | 2224 | 285695 | 904991 | 78551478 |
High density lipoprotein decreased | 188.63 | 9.81 | 147 | 287772 | 4508 | 79451961 |
Duodenal ulcer perforation | 188.29 | 9.81 | 13 | 287906 | 66198 | 79390271 |
Cognitive disorder | 186.15 | 9.81 | 616 | 287303 | 69310 | 79387159 |
Wound | 179.15 | 9.81 | 98 | 287821 | 116081 | 79340388 |
Blood triglycerides increased | 175.87 | 9.81 | 291 | 287628 | 20749 | 79435720 |
Death | 175.06 | 9.81 | 1262 | 286657 | 565252 | 78891217 |
Drug ineffective | 161.62 | 9.81 | 2841 | 285078 | 1078072 | 78378397 |
Treatment failure | 159.38 | 9.81 | 230 | 287689 | 170256 | 79286213 |
Asthma | 156.35 | 9.81 | 927 | 286992 | 134168 | 79322301 |
Contraindicated product administered | 153.80 | 9.81 | 206 | 287713 | 157332 | 79299137 |
Intentional overdose | 152.61 | 9.81 | 97 | 287822 | 105863 | 79350606 |
Therapeutic product effect decreased | 151.28 | 9.81 | 223 | 287696 | 163640 | 79292829 |
Neutropenia | 149.90 | 9.81 | 534 | 287385 | 287176 | 79169293 |
Immune-mediated myositis | 148.16 | 9.81 | 113 | 287806 | 3354 | 79453115 |
Helicobacter infection | 147.70 | 9.81 | 35 | 287884 | 69669 | 79386800 |
Blood pressure systolic increased | 145.54 | 9.81 | 552 | 287367 | 66434 | 79390035 |
Pericarditis | 143.95 | 9.81 | 100 | 287819 | 104136 | 79352333 |
Folliculitis | 143.60 | 9.81 | 16 | 287903 | 55364 | 79401105 |
Blood pressure increased | 141.99 | 9.81 | 1273 | 286646 | 210087 | 79246382 |
Low density lipoprotein decreased | 141.96 | 9.81 | 75 | 287844 | 1146 | 79455323 |
Infection | 141.54 | 9.81 | 426 | 287493 | 241286 | 79215183 |
Muscle spasms | 138.94 | 9.81 | 1093 | 286826 | 173637 | 79282832 |
Dyslipidaemia | 137.30 | 9.81 | 189 | 287730 | 11444 | 79445025 |
Infusion related reaction | 134.65 | 9.81 | 406 | 287513 | 229831 | 79226638 |
Myocardial infarction | 133.56 | 9.81 | 1128 | 286791 | 183001 | 79273468 |
Alopecia | 132.43 | 9.81 | 412 | 287507 | 230943 | 79225526 |
Asthenia | 128.38 | 9.81 | 2575 | 285344 | 509114 | 78947355 |
Sedation | 128.28 | 9.81 | 446 | 287473 | 51449 | 79405020 |
Euglycaemic diabetic ketoacidosis | 125.82 | 9.81 | 139 | 287780 | 6705 | 79449764 |
Reversible airways obstruction | 118.19 | 9.81 | 82 | 287837 | 2094 | 79454375 |
Acute myocardial infarction | 116.55 | 9.81 | 569 | 287350 | 76467 | 79380002 |
Impaired healing | 114.66 | 9.81 | 89 | 287830 | 87566 | 79368903 |
Sleep disorder due to general medical condition, insomnia type | 114.42 | 9.81 | 12 | 287907 | 43544 | 79412925 |
Product use issue | 114.26 | 9.81 | 382 | 287537 | 209440 | 79247029 |
Coronary artery disease | 114.08 | 9.81 | 504 | 287415 | 64970 | 79391499 |
Muscular weakness | 111.48 | 9.81 | 975 | 286944 | 159754 | 79296715 |
Disease progression | 111.47 | 9.81 | 320 | 287599 | 184042 | 79272427 |
Blood glucose increased | 110.73 | 9.81 | 753 | 287166 | 114222 | 79342247 |
Diabetic ketoacidosis | 104.92 | 9.81 | 316 | 287603 | 33806 | 79422663 |
Arthropathy | 103.03 | 9.81 | 313 | 287606 | 176798 | 79279671 |
Cardiac failure | 102.09 | 9.81 | 929 | 286990 | 153913 | 79302556 |
Rheumatoid factor negative | 100.65 | 9.81 | 59 | 287860 | 1114 | 79455355 |
Obstructive airways disorder | 100.20 | 9.81 | 295 | 287624 | 31164 | 79425305 |
Irritable bowel syndrome | 99.63 | 9.81 | 50 | 287869 | 62191 | 79394278 |
Blister | 94.16 | 9.81 | 180 | 287739 | 119296 | 79337173 |
Pyrexia | 93.16 | 9.81 | 1809 | 286110 | 676900 | 78779569 |
Stomatitis | 91.46 | 9.81 | 251 | 287668 | 146506 | 79309963 |
Chromaturia | 91.32 | 9.81 | 251 | 287668 | 25495 | 79430974 |
Coronary artery occlusion | 87.77 | 9.81 | 180 | 287739 | 15135 | 79441334 |
Drug interaction | 86.89 | 9.81 | 2036 | 285883 | 413147 | 79043322 |
Constipation | 86.35 | 9.81 | 1469 | 286450 | 281581 | 79174888 |
Conjunctivitis allergic | 84.58 | 9.81 | 61 | 287858 | 1659 | 79454810 |
Product use in unapproved indication | 83.40 | 9.81 | 545 | 287374 | 249814 | 79206655 |
Rales | 83.23 | 9.81 | 207 | 287712 | 19794 | 79436675 |
Diabetes mellitus | 83.12 | 9.81 | 526 | 287393 | 77864 | 79378605 |
General physical health deterioration | 82.93 | 9.81 | 617 | 287302 | 274621 | 79181848 |
Rheumatic fever | 82.88 | 9.81 | 5 | 287914 | 28520 | 79427949 |
Coma | 82.53 | 9.81 | 148 | 287771 | 100501 | 79355968 |
Cardiac failure chronic | 82.51 | 9.81 | 146 | 287773 | 10989 | 79445480 |
Pancytopenia | 80.78 | 9.81 | 316 | 287603 | 165429 | 79291040 |
Pregnancy | 80.21 | 9.81 | 4 | 287915 | 26847 | 79429622 |
Swelling | 79.34 | 9.81 | 458 | 287461 | 216253 | 79240216 |
Seizure | 79.24 | 9.81 | 381 | 287538 | 188453 | 79268016 |
Diabetes mellitus inadequate control | 77.72 | 9.81 | 228 | 287691 | 24036 | 79432433 |
Overdose | 77.68 | 9.81 | 371 | 287548 | 183835 | 79272634 |
Sepsis | 77.39 | 9.81 | 612 | 287307 | 268816 | 79187653 |
Febrile neutropenia | 76.36 | 9.81 | 504 | 287415 | 230495 | 79225974 |
Chronic kidney disease | 75.24 | 9.81 | 452 | 287467 | 65702 | 79390767 |
Erectile dysfunction | 74.39 | 9.81 | 164 | 287755 | 14500 | 79441969 |
Chest discomfort | 73.83 | 9.81 | 793 | 287126 | 137251 | 79319218 |
Condition aggravated | 73.20 | 9.81 | 1321 | 286598 | 499803 | 78956666 |
Angina unstable | 72.98 | 9.81 | 175 | 287744 | 16352 | 79440117 |
Cough | 72.86 | 9.81 | 1786 | 286133 | 365003 | 79091466 |
Tendon rupture | 72.44 | 9.81 | 145 | 287774 | 11981 | 79444488 |
Leukopenia | 71.31 | 9.81 | 201 | 287718 | 116312 | 79340157 |
Vital capacity decreased | 70.67 | 9.81 | 56 | 287863 | 1760 | 79454709 |
Psoriasis | 69.28 | 9.81 | 557 | 287362 | 89030 | 79367439 |
Muscle injury | 67.81 | 9.81 | 46 | 287873 | 48515 | 79407954 |
Mucosal inflammation | 67.65 | 9.81 | 105 | 287814 | 75475 | 79380994 |
Intentional self-injury | 67.27 | 9.81 | 17 | 287902 | 32402 | 79424067 |
Congenital hiatus hernia | 66.92 | 9.81 | 40 | 287879 | 784 | 79455685 |
Fall | 66.90 | 9.81 | 2266 | 285653 | 485363 | 78971106 |
Computerised tomogram coronary artery abnormal | 65.72 | 9.81 | 26 | 287893 | 192 | 79456277 |
Bronchiectasis | 65.72 | 9.81 | 204 | 287715 | 22182 | 79434287 |
Acute coronary syndrome | 65.24 | 9.81 | 196 | 287723 | 20937 | 79435532 |
Therapy non-responder | 65.19 | 9.81 | 148 | 287771 | 92157 | 79364312 |
Respiratory arrest | 64.99 | 9.81 | 67 | 287852 | 57483 | 79398986 |
Coronary artery stenosis | 64.90 | 9.81 | 141 | 287778 | 12343 | 79444126 |
Cytomegalovirus infection | 64.24 | 9.81 | 37 | 287882 | 42607 | 79413862 |
Suicide attempt | 63.55 | 9.81 | 127 | 287792 | 82805 | 79373664 |
Device expulsion | 63.33 | 9.81 | 9 | 287910 | 25852 | 79430617 |
Myositis | 62.24 | 9.81 | 181 | 287738 | 18987 | 79437482 |
Bone marrow failure | 61.78 | 9.81 | 56 | 287863 | 51051 | 79405418 |
Pain in extremity | 61.38 | 9.81 | 1737 | 286182 | 362801 | 79093668 |
Injury | 60.83 | 9.81 | 117 | 287802 | 77379 | 79379090 |
Glycosylated haemoglobin increased | 60.75 | 9.81 | 180 | 287739 | 19080 | 79437389 |
Atrial fibrillation | 60.29 | 9.81 | 1027 | 286892 | 196859 | 79259610 |
Productive cough | 60.25 | 9.81 | 534 | 287385 | 87797 | 79368672 |
Abortion spontaneous | 60.22 | 9.81 | 16 | 287903 | 29491 | 79426978 |
Ischaemic stroke | 59.20 | 9.81 | 257 | 287662 | 32874 | 79423595 |
Hypersensitivity | 57.12 | 9.81 | 638 | 287281 | 261601 | 79194868 |
Vascular stent stenosis | 57.10 | 9.81 | 46 | 287873 | 1481 | 79454988 |
Premature delivery | 55.56 | 9.81 | 9 | 287910 | 23458 | 79433011 |
Drug resistance | 55.02 | 9.81 | 43 | 287876 | 42170 | 79414299 |
Pancreatitis | 55.01 | 9.81 | 430 | 287489 | 68145 | 79388324 |
Rheumatoid factor positive | 54.64 | 9.81 | 82 | 287837 | 59757 | 79396712 |
Lung diffusion test decreased | 54.45 | 9.81 | 42 | 287877 | 1268 | 79455201 |
Malignant mediastinal neoplasm | 53.71 | 9.81 | 43 | 287876 | 1372 | 79455097 |
Restrictive pulmonary disease | 53.50 | 9.81 | 56 | 287863 | 2539 | 79453930 |
Interstitial lung disease | 53.47 | 9.81 | 632 | 287287 | 111968 | 79344501 |
Thrombocytopenia | 52.90 | 9.81 | 658 | 287261 | 264601 | 79191868 |
Product substitution issue | 52.59 | 9.81 | 177 | 287742 | 20079 | 79436390 |
Septic shock | 52.53 | 9.81 | 246 | 287673 | 122555 | 79333914 |
Drug intolerance | 52.36 | 9.81 | 656 | 287263 | 263463 | 79193006 |
Eosinophil count increased | 52.20 | 9.81 | 158 | 287761 | 16947 | 79439522 |
Blood creatinine increased | 52.15 | 9.81 | 818 | 287101 | 154239 | 79302230 |
Arteriosclerosis coronary artery | 51.97 | 9.81 | 162 | 287757 | 17654 | 79438815 |
Adjustment disorder | 51.80 | 9.81 | 68 | 287851 | 3932 | 79452537 |
Spirometry abnormal | 51.76 | 9.81 | 36 | 287883 | 923 | 79455546 |
5-hydroxyindolacetic acid in urine increased | 51.60 | 9.81 | 23 | 287896 | 236 | 79456233 |
Hepatojugular reflux | 51.45 | 9.81 | 31 | 287888 | 617 | 79455852 |
Needle fatigue | 51.37 | 9.81 | 35 | 287884 | 867 | 79455602 |
Mobility decreased | 51.25 | 9.81 | 670 | 287249 | 121505 | 79334964 |
Bone erosion | 50.88 | 9.81 | 161 | 287758 | 17686 | 79438783 |
Fibromyalgia | 49.75 | 9.81 | 98 | 287821 | 64242 | 79392227 |
Crush syndrome | 49.70 | 9.81 | 21 | 287898 | 187 | 79456282 |
Ascites | 49.52 | 9.81 | 126 | 287793 | 75436 | 79381033 |
Respiratory depression | 49.26 | 9.81 | 19 | 287900 | 27611 | 79428858 |
Muscle disorder | 49.13 | 9.81 | 80 | 287839 | 5627 | 79450842 |
Cardio-respiratory arrest | 49.03 | 9.81 | 213 | 287706 | 108297 | 79348172 |
Gait spastic | 48.93 | 9.81 | 38 | 287881 | 1159 | 79455310 |
Exercise tolerance decreased | 48.93 | 9.81 | 104 | 287815 | 8967 | 79447502 |
Drug-induced liver injury | 48.38 | 9.81 | 406 | 287513 | 65711 | 79390758 |
Hypotension | 48.26 | 9.81 | 1996 | 285923 | 438321 | 79018148 |
Toxic epidermal necrolysis | 48.00 | 9.81 | 54 | 287865 | 44527 | 79411942 |
Chest pain | 47.99 | 9.81 | 1347 | 286572 | 280957 | 79175512 |
Somnolence | 47.95 | 9.81 | 592 | 287327 | 238389 | 79218080 |
Polymyositis | 47.94 | 9.81 | 57 | 287862 | 2979 | 79453490 |
Stenosis | 47.68 | 9.81 | 51 | 287868 | 2371 | 79454098 |
Multiple organ dysfunction syndrome | 47.34 | 9.81 | 248 | 287671 | 119998 | 79336471 |
Hepatic function abnormal | 47.32 | 9.81 | 437 | 287482 | 72670 | 79383799 |
Blood mercury abnormal | 47.32 | 9.81 | 21 | 287898 | 213 | 79456256 |
Electrocardiogram Q wave abnormal | 47.10 | 9.81 | 29 | 287890 | 601 | 79455868 |
Depressed level of consciousness | 47.00 | 9.81 | 545 | 287374 | 96107 | 79360362 |
Cerebral infarction | 46.88 | 9.81 | 304 | 287615 | 45372 | 79411097 |
Haemorrhagic stroke | 46.68 | 9.81 | 115 | 287804 | 10931 | 79445538 |
Muscle discomfort | 46.11 | 9.81 | 22 | 287897 | 267 | 79456202 |
Nephritic syndrome | 46.08 | 9.81 | 25 | 287894 | 404 | 79456065 |
Carotid artery thrombosis | 46.05 | 9.81 | 56 | 287863 | 2997 | 79453472 |
Mite allergy | 45.89 | 9.81 | 37 | 287882 | 1193 | 79455276 |
Troponin increased | 44.58 | 9.81 | 162 | 287757 | 19093 | 79437376 |
Arterial occlusive disease | 44.52 | 9.81 | 96 | 287823 | 8360 | 79448109 |
Hyper IgE syndrome | 44.52 | 9.81 | 27 | 287892 | 544 | 79455925 |
Cataract | 44.16 | 9.81 | 379 | 287540 | 61741 | 79394728 |
Pulmonary function test abnormal | 43.98 | 9.81 | 64 | 287855 | 4080 | 79452389 |
Device related infection | 43.36 | 9.81 | 36 | 287883 | 34258 | 79422211 |
Neurologic neglect syndrome | 43.32 | 9.81 | 53 | 287866 | 2854 | 79453615 |
Blood pressure inadequately controlled | 43.22 | 9.81 | 79 | 287840 | 6098 | 79450371 |
Muscle rupture | 43.15 | 9.81 | 60 | 287859 | 3667 | 79452802 |
Respiratory failure | 43.08 | 9.81 | 431 | 287488 | 180480 | 79275989 |
Arteriosclerosis | 42.75 | 9.81 | 154 | 287765 | 18073 | 79438396 |
Poisoning | 42.44 | 9.81 | 19 | 287900 | 25253 | 79431216 |
Malignant neoplasm progression | 42.28 | 9.81 | 302 | 287617 | 135688 | 79320781 |
Hip arthroplasty | 42.24 | 9.81 | 40 | 287879 | 35716 | 79420753 |
Middle insomnia | 42.24 | 9.81 | 141 | 287778 | 15928 | 79440541 |
White blood cell count decreased | 42.21 | 9.81 | 455 | 287464 | 187833 | 79268636 |
Orbital myositis | 42.15 | 9.81 | 18 | 287901 | 165 | 79456304 |
Weight decreased | 42.11 | 9.81 | 1624 | 286295 | 353574 | 79102895 |
Mental status changes | 42.09 | 9.81 | 114 | 287805 | 66845 | 79389624 |
Cystitis | 41.93 | 9.81 | 330 | 287589 | 52402 | 79404067 |
Rhinitis perennial | 41.88 | 9.81 | 22 | 287897 | 332 | 79456137 |
Red blood cell sedimentation rate abnormal | 41.66 | 9.81 | 168 | 287751 | 20795 | 79435674 |
Type 2 diabetes mellitus | 41.39 | 9.81 | 350 | 287569 | 56772 | 79399697 |
Diastolic dysfunction | 40.96 | 9.81 | 108 | 287811 | 10703 | 79445766 |
Carotid arteriosclerosis | 40.52 | 9.81 | 49 | 287870 | 2607 | 79453862 |
Hemiplegia | 40.09 | 9.81 | 132 | 287787 | 14807 | 79441662 |
Ulnar tunnel syndrome | 39.89 | 9.81 | 10 | 287909 | 9 | 79456460 |
Mycotic allergy | 39.12 | 9.81 | 37 | 287882 | 1482 | 79454987 |
Pulmonary valve disease | 38.90 | 9.81 | 20 | 287899 | 288 | 79456181 |
Hypoglycaemia | 38.85 | 9.81 | 548 | 287371 | 101046 | 79355423 |
Drug ineffective for unapproved indication | 38.80 | 9.81 | 79 | 287840 | 51159 | 79405310 |
Dust allergy | 38.77 | 9.81 | 37 | 287882 | 1499 | 79454970 |
Hyperglycaemia | 38.49 | 9.81 | 406 | 287513 | 69929 | 79386540 |
Muscle necrosis | 38.48 | 9.81 | 36 | 287883 | 1422 | 79455047 |
Liver disorder | 38.23 | 9.81 | 415 | 287504 | 72002 | 79384467 |
Sputum culture positive | 38.12 | 9.81 | 57 | 287862 | 3724 | 79452745 |
Cerebral haemorrhage | 37.96 | 9.81 | 346 | 287573 | 57327 | 79399142 |
Skin haemorrhage | 37.81 | 9.81 | 112 | 287807 | 11869 | 79444600 |
Hypertonic bladder | 37.68 | 9.81 | 60 | 287859 | 4141 | 79452328 |
Cerebrovascular accident | 37.61 | 9.81 | 778 | 287141 | 154514 | 79301955 |
Drug withdrawal syndrome | 37.44 | 9.81 | 42 | 287877 | 34676 | 79421793 |
Lipoprotein (a) increased | 37.43 | 9.81 | 13 | 287906 | 63 | 79456406 |
Thrombotic microangiopathy | 37.43 | 9.81 | 13 | 287906 | 20156 | 79436313 |
Haemophagocytic lymphohistiocytosis | 37.33 | 9.81 | 16 | 287903 | 21821 | 79434648 |
Neutropenic sepsis | 37.30 | 9.81 | 26 | 287893 | 27038 | 79429431 |
Transient ischaemic attack | 37.19 | 9.81 | 321 | 287598 | 52374 | 79404095 |
Amyotrophic lateral sclerosis | 37.12 | 9.81 | 39 | 287880 | 1776 | 79454693 |
Drug dependence | 37.09 | 9.81 | 56 | 287863 | 40713 | 79415756 |
Haematuria | 37.04 | 9.81 | 396 | 287523 | 68440 | 79388029 |
Malignant melanoma in situ | 37.02 | 9.81 | 45 | 287874 | 2407 | 79454062 |
Nasal oedema | 36.97 | 9.81 | 38 | 287881 | 1686 | 79454783 |
Generalised tonic-clonic seizure | 36.50 | 9.81 | 64 | 287855 | 43846 | 79412623 |
Gangrene | 36.49 | 9.81 | 92 | 287827 | 8872 | 79447597 |
Autoimmune myositis | 36.33 | 9.81 | 19 | 287900 | 284 | 79456185 |
Lipids increased | 36.14 | 9.81 | 37 | 287882 | 1634 | 79454835 |
Body temperature decreased | 36.14 | 9.81 | 219 | 287700 | 31926 | 79424543 |
Blood immunoglobulin E increased | 35.93 | 9.81 | 71 | 287848 | 5811 | 79450658 |
Carotid artery stenosis | 35.77 | 9.81 | 90 | 287829 | 8668 | 79447801 |
Hepatocellular injury | 35.75 | 9.81 | 294 | 287625 | 47299 | 79409170 |
Discomfort | 35.72 | 9.81 | 286 | 287633 | 125331 | 79331138 |
Pancreatic neuroendocrine tumour | 35.64 | 9.81 | 25 | 287894 | 650 | 79455819 |
Relapsing-remitting multiple sclerosis | 35.36 | 9.81 | 35 | 287884 | 1484 | 79454985 |
Sinus congestion | 35.28 | 9.81 | 154 | 287765 | 19742 | 79436727 |
Posterior reversible encephalopathy syndrome | 35.24 | 9.81 | 26 | 287893 | 26255 | 79430214 |
Lipids abnormal | 35.14 | 9.81 | 24 | 287895 | 597 | 79455872 |
Neutrophil count decreased | 34.66 | 9.81 | 198 | 287721 | 93761 | 79362708 |
Palpitations | 34.60 | 9.81 | 646 | 287273 | 125964 | 79330505 |
Hypercholesterolaemia | 34.49 | 9.81 | 170 | 287749 | 22925 | 79433544 |
Encephalopathy | 34.43 | 9.81 | 126 | 287793 | 67271 | 79389198 |
Renal failure | 34.43 | 9.81 | 960 | 286959 | 200008 | 79256461 |
Mitral valve incompetence | 34.29 | 9.81 | 198 | 287721 | 28367 | 79428102 |
Low cardiac output syndrome | 33.92 | 9.81 | 29 | 287890 | 1016 | 79455453 |
Glomerular filtration rate decreased | 33.83 | 9.81 | 167 | 287752 | 22535 | 79433934 |
Androgenetic alopecia | 33.73 | 9.81 | 15 | 287904 | 153 | 79456316 |
Skin laceration | 33.63 | 9.81 | 199 | 287720 | 28763 | 79427706 |
Coronary artery restenosis | 33.52 | 9.81 | 32 | 287887 | 1297 | 79455172 |
Poisoning deliberate | 33.48 | 9.81 | 13 | 287906 | 18815 | 79437654 |
Dyspnoea exertional | 33.42 | 9.81 | 470 | 287449 | 86603 | 79369866 |
Bronchial secretion retention | 33.28 | 9.81 | 56 | 287863 | 4048 | 79452421 |
Supine hypertension | 32.93 | 9.81 | 20 | 287899 | 404 | 79456065 |
Lower respiratory tract infection | 32.81 | 9.81 | 303 | 287616 | 128917 | 79327552 |
Pollakiuria | 32.74 | 9.81 | 239 | 287680 | 37078 | 79419391 |
Injection site reaction | 32.42 | 9.81 | 96 | 287823 | 54689 | 79401780 |
Micturition urgency | 32.41 | 9.81 | 110 | 287809 | 12531 | 79443938 |
Transplant rejection | 32.04 | 9.81 | 15 | 287904 | 19422 | 79437047 |
Blood pressure fluctuation | 31.92 | 9.81 | 377 | 287542 | 66768 | 79389701 |
Transaminases increased | 31.84 | 9.81 | 306 | 287613 | 51437 | 79405032 |
Blood pressure systolic abnormal | 31.74 | 9.81 | 135 | 287784 | 17112 | 79439357 |
Rash | 31.74 | 9.81 | 1736 | 286183 | 576622 | 78879847 |
Muscle atrophy | 31.72 | 9.81 | 101 | 287818 | 11131 | 79445338 |
Ventricular hypokinesia | 31.46 | 9.81 | 89 | 287830 | 9190 | 79447279 |
Alanine aminotransferase increased | 31.42 | 9.81 | 789 | 287130 | 161781 | 79294688 |
Gastrooesophageal reflux disease | 31.35 | 9.81 | 540 | 287379 | 103706 | 79352763 |
Bronchopulmonary aspergillosis | 31.28 | 9.81 | 21 | 287898 | 22273 | 79434196 |
Pneumocystis jirovecii pneumonia | 31.20 | 9.81 | 43 | 287876 | 32465 | 79424004 |
Knee arthroplasty | 30.81 | 9.81 | 69 | 287850 | 43179 | 79413290 |
Pathogen resistance | 30.78 | 9.81 | 7 | 287912 | 14335 | 79442134 |
Helicobacter gastritis | 30.74 | 9.81 | 41 | 287878 | 2408 | 79454061 |
Agitation | 30.72 | 9.81 | 222 | 287697 | 99493 | 79356976 |
Myelosuppression | 30.62 | 9.81 | 62 | 287857 | 40234 | 79416235 |
Blood cholesterol abnormal | 30.26 | 9.81 | 48 | 287871 | 3302 | 79453167 |
Upper-airway cough syndrome | 30.20 | 9.81 | 102 | 287817 | 11591 | 79444878 |
Cytomegalovirus viraemia | 30.17 | 9.81 | 5 | 287914 | 12816 | 79443653 |
Lactic acidosis | 29.98 | 9.81 | 387 | 287532 | 69972 | 79386497 |
Prescribed overdose | 29.90 | 9.81 | 57 | 287862 | 37826 | 79418643 |
Blood glucose abnormal | 29.83 | 9.81 | 95 | 287824 | 10471 | 79445998 |
Wheezing | 29.74 | 9.81 | 589 | 287330 | 116075 | 79340394 |
Pulmonary mass | 29.64 | 9.81 | 193 | 287726 | 28841 | 79427628 |
Vomiting | 29.63 | 9.81 | 2038 | 285881 | 663790 | 78792679 |
Gastrointestinal disorder | 29.56 | 9.81 | 290 | 287629 | 121915 | 79334554 |
N-terminal prohormone brain natriuretic peptide abnormal | 29.47 | 9.81 | 16 | 287903 | 259 | 79456210 |
Akathisia | 29.41 | 9.81 | 6 | 287913 | 13253 | 79443216 |
Myocardial ischaemia | 29.41 | 9.81 | 175 | 287744 | 25344 | 79431125 |
Haemoglobin increased | 29.33 | 9.81 | 67 | 287852 | 6065 | 79450404 |
Left ventricular enlargement | 29.02 | 9.81 | 23 | 287896 | 723 | 79455746 |
Haematotoxicity | 28.80 | 9.81 | 10 | 287909 | 15509 | 79440960 |
Dermatomyositis | 28.80 | 9.81 | 49 | 287870 | 3574 | 79452895 |
Tricuspid valve incompetence | 28.66 | 9.81 | 144 | 287775 | 19568 | 79436901 |
Oropharyngeal discomfort | 28.60 | 9.81 | 73 | 287846 | 7093 | 79449376 |
Multiple allergies | 28.58 | 9.81 | 93 | 287826 | 10367 | 79446102 |
Nipple inflammation | 28.54 | 9.81 | 10 | 287909 | 50 | 79456419 |
Mydriasis | 28.49 | 9.81 | 14 | 287905 | 17629 | 79438840 |
Acute respiratory distress syndrome | 28.47 | 9.81 | 74 | 287845 | 43993 | 79412476 |
Sopor | 28.46 | 9.81 | 47 | 287872 | 32963 | 79423506 |
Aspergillus infection | 28.33 | 9.81 | 17 | 287902 | 19144 | 79437325 |
Occult blood | 28.29 | 9.81 | 33 | 287886 | 1690 | 79454779 |
Skin necrosis | 28.24 | 9.81 | 15 | 287904 | 18072 | 79438397 |
Dyspnoea | 28.21 | 9.81 | 3519 | 284400 | 853506 | 78602963 |
Aspartate aminotransferase increased | 28.03 | 9.81 | 677 | 287242 | 137964 | 79318505 |
Eczema | 27.95 | 9.81 | 247 | 287672 | 40571 | 79415898 |
Inspiratory capacity abnormal | 27.91 | 9.81 | 12 | 287907 | 112 | 79456357 |
Blood thyroid stimulating hormone abnormal | 27.86 | 9.81 | 25 | 287894 | 935 | 79455534 |
Intentional product use issue | 27.85 | 9.81 | 384 | 287535 | 151728 | 79304741 |
Musculoskeletal toxicity | 27.58 | 9.81 | 14 | 287905 | 196 | 79456273 |
Dizziness | 27.35 | 9.81 | 2231 | 285688 | 524210 | 78932259 |
Status epilepticus | 27.32 | 9.81 | 30 | 287889 | 25011 | 79431458 |
Candida infection | 27.20 | 9.81 | 61 | 287858 | 38153 | 79418316 |
Aortic valve incompetence | 27.19 | 9.81 | 86 | 287833 | 9444 | 79447025 |
Injection site erythema | 27.14 | 9.81 | 168 | 287751 | 78029 | 79378440 |
Caesarean section | 27.14 | 9.81 | 6 | 287913 | 12529 | 79443940 |
Blood pressure diastolic abnormal | 27.03 | 9.81 | 139 | 287780 | 19063 | 79437406 |
Pericardial disease | 27.01 | 9.81 | 20 | 287899 | 567 | 79455902 |
Hepatitis | 26.98 | 9.81 | 314 | 287605 | 55413 | 79401056 |
Neuroleptic malignant syndrome | 26.91 | 9.81 | 36 | 287883 | 27523 | 79428946 |
Tumour lysis syndrome | 26.88 | 9.81 | 28 | 287891 | 23911 | 79432558 |
Cytokine release syndrome | 26.83 | 9.81 | 56 | 287863 | 35942 | 79420527 |
Albuminuria | 26.82 | 9.81 | 22 | 287897 | 727 | 79455742 |
Unresponsive to stimuli | 26.75 | 9.81 | 107 | 287812 | 55681 | 79400788 |
Adverse event | 26.71 | 9.81 | 119 | 287800 | 60095 | 79396374 |
Tachycardia | 26.70 | 9.81 | 466 | 287453 | 177302 | 79279167 |
Aortic aneurysm | 26.70 | 9.81 | 79 | 287840 | 8367 | 79448102 |
Vascular stent thrombosis | 26.66 | 9.81 | 48 | 287871 | 3662 | 79452807 |
Stent placement | 26.62 | 9.81 | 67 | 287852 | 6453 | 79450016 |
Hyperkalaemia | 26.36 | 9.81 | 569 | 287350 | 113829 | 79342640 |
Hepatic encephalopathy | 26.31 | 9.81 | 29 | 287890 | 24137 | 79432332 |
Withdrawal syndrome | 26.30 | 9.81 | 35 | 287884 | 26819 | 79429650 |
Cardiac arrest | 26.21 | 9.81 | 450 | 287469 | 171646 | 79284823 |
Aggression | 26.21 | 9.81 | 95 | 287824 | 50863 | 79405606 |
Pancreatitis acute | 26.05 | 9.81 | 284 | 287635 | 49320 | 79407149 |
Goitre | 25.92 | 9.81 | 60 | 287859 | 5479 | 79450990 |
Serotonin syndrome | 25.86 | 9.81 | 80 | 287839 | 44947 | 79411522 |
Ejection fraction decreased | 25.65 | 9.81 | 213 | 287706 | 34364 | 79422105 |
Myoglobin blood increased | 25.55 | 9.81 | 43 | 287876 | 3108 | 79453361 |
Ulcer | 25.54 | 9.81 | 43 | 287876 | 29929 | 79426540 |
Affect lability | 25.45 | 9.81 | 94 | 287825 | 11165 | 79445304 |
Blood triglycerides abnormal | 25.43 | 9.81 | 18 | 287901 | 475 | 79455994 |
Joint swelling | 25.42 | 9.81 | 821 | 287098 | 287825 | 79168644 |
Amblyopia | 25.39 | 9.81 | 14 | 287905 | 234 | 79456235 |
Colitis ulcerative | 25.23 | 9.81 | 213 | 287706 | 34529 | 79421940 |
Sinusitis | 25.21 | 9.81 | 526 | 287393 | 194975 | 79261494 |
Dystonia | 25.21 | 9.81 | 24 | 287895 | 21375 | 79435094 |
Hyperlipidaemia | 25.16 | 9.81 | 171 | 287748 | 25922 | 79430547 |
Physical examination abnormal | 25.10 | 9.81 | 15 | 287904 | 294 | 79456175 |
Rheumatoid nodule | 25.05 | 9.81 | 16 | 287903 | 17422 | 79439047 |
Substance abuse | 25.00 | 9.81 | 4 | 287915 | 10522 | 79445947 |
Adverse drug reaction | 24.98 | 9.81 | 139 | 287780 | 66253 | 79390216 |
Peripheral arterial occlusive disease | 24.93 | 9.81 | 76 | 287843 | 8182 | 79448287 |
Blood creatine phosphokinase | 24.91 | 9.81 | 12 | 287907 | 149 | 79456320 |
Lipase increased | 24.45 | 9.81 | 121 | 287798 | 16345 | 79440124 |
Gait disturbance | 24.38 | 9.81 | 948 | 286971 | 206558 | 79249911 |
Neoplasm progression | 24.23 | 9.81 | 100 | 287819 | 51582 | 79404887 |
Tubulointerstitial nephritis | 23.96 | 9.81 | 227 | 287692 | 38008 | 79418461 |
Total bile acids increased | 23.87 | 9.81 | 10 | 287909 | 87 | 79456382 |
Guillain-Barre syndrome | 23.86 | 9.81 | 79 | 287840 | 8886 | 79447583 |
Lip dry | 23.76 | 9.81 | 13 | 287906 | 15405 | 79441064 |
Aplastic anaemia | 23.64 | 9.81 | 18 | 287901 | 17887 | 79438582 |
Bundle branch block left | 23.46 | 9.81 | 93 | 287826 | 11420 | 79445049 |
Blood test abnormal | 23.42 | 9.81 | 126 | 287793 | 17584 | 79438885 |
Eye haemorrhage | 23.36 | 9.81 | 83 | 287836 | 9674 | 79446795 |
Miosis | 23.35 | 9.81 | 14 | 287905 | 15775 | 79440694 |
Inflammation | 23.30 | 9.81 | 221 | 287698 | 93532 | 79362937 |
Left ventricular hypertrophy | 23.29 | 9.81 | 91 | 287828 | 11100 | 79445369 |
Ventricular extrasystoles | 23.27 | 9.81 | 136 | 287783 | 19568 | 79436901 |
Forced vital capacity decreased | 23.15 | 9.81 | 30 | 287889 | 1713 | 79454756 |
Eosinophilia | 23.08 | 9.81 | 258 | 287661 | 45087 | 79411382 |
Bacterial infection | 23.03 | 9.81 | 49 | 287870 | 31231 | 79425238 |
Enterococcal infection | 23.00 | 9.81 | 14 | 287905 | 15646 | 79440823 |
Abnormal behaviour | 22.89 | 9.81 | 62 | 287857 | 36359 | 79420110 |
Total lung capacity decreased | 22.71 | 9.81 | 39 | 287880 | 2866 | 79453603 |
Chronic obstructive pulmonary disease | 22.70 | 9.81 | 434 | 287485 | 84985 | 79371484 |
Diabetic metabolic decompensation | 22.54 | 9.81 | 42 | 287877 | 3290 | 79453179 |
Immune reconstitution inflammatory syndrome | 22.33 | 9.81 | 11 | 287908 | 13830 | 79442639 |
Normochromic normocytic anaemia | 22.30 | 9.81 | 70 | 287849 | 7657 | 79448812 |
Mycobacterium test positive | 22.25 | 9.81 | 16 | 287903 | 433 | 79456036 |
Abdominal discomfort | 22.10 | 9.81 | 713 | 287206 | 250014 | 79206455 |
Necrotising myositis | 22.02 | 9.81 | 25 | 287894 | 1243 | 79455226 |
Lower limb fracture | 21.99 | 9.81 | 31 | 287888 | 23184 | 79433285 |
Grip strength decreased | 21.94 | 9.81 | 28 | 287891 | 21841 | 79434628 |
Vertigo | 21.92 | 9.81 | 361 | 287558 | 68721 | 79387748 |
Hepatic neoplasm | 21.71 | 9.81 | 42 | 287877 | 3384 | 79453085 |
Creutzfeldt-Jakob disease | 21.64 | 9.81 | 12 | 287907 | 203 | 79456266 |
Coordination abnormal | 21.44 | 9.81 | 121 | 287798 | 17191 | 79439278 |
Carcinoid tumour | 21.30 | 9.81 | 17 | 287902 | 540 | 79455929 |
Blood pressure diastolic decreased | 21.28 | 9.81 | 184 | 287735 | 30032 | 79426437 |
Panniculitis | 21.25 | 9.81 | 9 | 287910 | 12362 | 79444107 |
Hyperthyroidism | 21.09 | 9.81 | 145 | 287774 | 22064 | 79434405 |
Anaemia | 20.78 | 9.81 | 1356 | 286563 | 443659 | 79012810 |
Confabulation | 20.77 | 9.81 | 16 | 287903 | 482 | 79455987 |
Discontinued product administered | 20.75 | 9.81 | 9 | 287910 | 86 | 79456383 |
Coagulopathy | 20.65 | 9.81 | 64 | 287855 | 35942 | 79420527 |
Mucormycosis | 20.61 | 9.81 | 3 | 287916 | 8466 | 79448003 |
Plasmapheresis | 20.57 | 9.81 | 18 | 287901 | 651 | 79455818 |
Growth hormone deficiency | 20.54 | 9.81 | 15 | 287904 | 416 | 79456053 |
Pulmonary haemorrhage | 20.47 | 9.81 | 14 | 287905 | 14703 | 79441766 |
Ventricular hyperkinesia | 20.43 | 9.81 | 13 | 287906 | 286 | 79456183 |
Device issue | 20.35 | 9.81 | 42 | 287877 | 27066 | 79429403 |
Sinus pain | 20.29 | 9.81 | 43 | 287876 | 3699 | 79452770 |
Haemorrhage subcutaneous | 20.25 | 9.81 | 50 | 287869 | 4759 | 79451710 |
Sneezing | 20.19 | 9.81 | 131 | 287788 | 19552 | 79436917 |
Metabolic acidosis | 20.15 | 9.81 | 414 | 287505 | 82115 | 79374354 |
Anastomotic infection | 20.09 | 9.81 | 10 | 287909 | 134 | 79456335 |
Hepatic enzyme abnormal | 20.06 | 9.81 | 68 | 287851 | 7742 | 79448727 |
Dermatitis allergic | 20.05 | 9.81 | 123 | 287796 | 18007 | 79438462 |
Platelet distribution width increased | 20.02 | 9.81 | 10 | 287909 | 135 | 79456334 |
Progressive multifocal leukoencephalopathy | 20.02 | 9.81 | 27 | 287892 | 20573 | 79435896 |
Neurotoxicity | 19.96 | 9.81 | 56 | 287863 | 32462 | 79424007 |
Aortic stenosis | 19.91 | 9.81 | 66 | 287853 | 7429 | 79449040 |
Cholestasis | 19.88 | 9.81 | 281 | 287638 | 51828 | 79404641 |
Acute myeloid leukaemia | 19.85 | 9.81 | 52 | 287867 | 30833 | 79425636 |
Ageusia | 19.78 | 9.81 | 115 | 287804 | 16517 | 79439952 |
Brain natriuretic peptide abnormal | 19.74 | 9.81 | 19 | 287900 | 778 | 79455691 |
Low density lipoprotein abnormal | 19.70 | 9.81 | 15 | 287904 | 444 | 79456025 |
Myopathy toxic | 19.67 | 9.81 | 22 | 287897 | 1076 | 79455393 |
Photosensitivity reaction | 19.51 | 9.81 | 137 | 287782 | 20990 | 79435479 |
Pneumonia | 19.45 | 9.81 | 2087 | 285832 | 658159 | 78798310 |
Mean platelet volume increased | 19.31 | 9.81 | 22 | 287897 | 1098 | 79455371 |
Endocrine ophthalmopathy | 19.26 | 9.81 | 18 | 287901 | 710 | 79455759 |
Autoimmune hepatitis | 19.24 | 9.81 | 89 | 287830 | 11694 | 79444775 |
Fractured coccyx | 19.21 | 9.81 | 21 | 287898 | 1001 | 79455468 |
Benign prostatic hyperplasia | 19.18 | 9.81 | 88 | 287831 | 11524 | 79444945 |
Rheumatic disorder | 19.15 | 9.81 | 38 | 287881 | 3120 | 79453349 |
Glomerular filtration rate | 19.09 | 9.81 | 10 | 287909 | 150 | 79456319 |
Pulmonary embolism | 18.98 | 9.81 | 473 | 287446 | 171181 | 79285288 |
Ketoacidosis | 18.97 | 9.81 | 67 | 287852 | 7787 | 79448682 |
Oral candidiasis | 18.95 | 9.81 | 50 | 287869 | 29578 | 79426891 |
Oedema peripheral | 18.84 | 9.81 | 1102 | 286817 | 251186 | 79205283 |
Blood cholesterol decreased | 18.83 | 9.81 | 27 | 287892 | 1698 | 79454771 |
Eyelid disorder | 18.78 | 9.81 | 29 | 287890 | 1949 | 79454520 |
Cystitis haemorrhagic | 18.66 | 9.81 | 5 | 287914 | 9167 | 79447302 |
Chronic sinusitis | 18.64 | 9.81 | 12 | 287907 | 13014 | 79443455 |
Epilepsy | 18.58 | 9.81 | 80 | 287839 | 40780 | 79415689 |
Cytopenia | 18.54 | 9.81 | 28 | 287891 | 20355 | 79436114 |
Hepatitis C | 18.46 | 9.81 | 10 | 287909 | 11915 | 79444554 |
Mitral valve thickening | 18.43 | 9.81 | 14 | 287905 | 413 | 79456056 |
Cardiac discomfort | 18.42 | 9.81 | 23 | 287896 | 1265 | 79455204 |
Total cholesterol/HDL ratio abnormal | 18.39 | 9.81 | 8 | 287911 | 77 | 79456392 |
Injection site pain | 18.34 | 9.81 | 344 | 287575 | 129494 | 79326975 |
Dyspnoea at rest | 18.25 | 9.81 | 63 | 287856 | 7239 | 79449230 |
Dysgeusia | 18.22 | 9.81 | 299 | 287620 | 56878 | 79399591 |
Procollagen type I C-terminal propeptide increased | 18.20 | 9.81 | 6 | 287913 | 24 | 79456445 |
Blood creatine increased | 18.17 | 9.81 | 75 | 287844 | 9380 | 79447089 |
Suicidal ideation | 18.11 | 9.81 | 182 | 287737 | 76158 | 79380311 |
Gynaecomastia | 18.10 | 9.81 | 65 | 287854 | 7616 | 79448853 |
Supraventricular extrasystoles | 18.09 | 9.81 | 61 | 287858 | 6926 | 79449543 |
Blood calcium increased | 18.06 | 9.81 | 80 | 287839 | 10320 | 79446149 |
Incorrect route of product administration | 18.04 | 9.81 | 65 | 287854 | 34864 | 79421605 |
Retro-orbital neoplasm | 18.01 | 9.81 | 7 | 287912 | 49 | 79456420 |
Multi-organ disorder | 17.98 | 9.81 | 33 | 287886 | 2555 | 79453914 |
Parosmia | 17.95 | 9.81 | 61 | 287858 | 6953 | 79449516 |
Intermittent claudication | 17.81 | 9.81 | 39 | 287880 | 3432 | 79453037 |
Therapy partial responder | 17.74 | 9.81 | 22 | 287897 | 17375 | 79439094 |
Burning sensation | 17.72 | 9.81 | 304 | 287615 | 58328 | 79398141 |
Hypertension | 17.69 | 9.81 | 1406 | 286513 | 329586 | 79126883 |
Burns second degree | 17.62 | 9.81 | 33 | 287886 | 2595 | 79453874 |
Angiocardiogram | 17.61 | 9.81 | 11 | 287908 | 234 | 79456235 |
Lipoma | 17.58 | 9.81 | 36 | 287883 | 3023 | 79453446 |
Multiple-drug resistance | 17.55 | 9.81 | 5 | 287914 | 8803 | 79447666 |
Monoparesis | 17.51 | 9.81 | 39 | 287880 | 3472 | 79452997 |
Intentional product misuse | 17.50 | 9.81 | 240 | 287679 | 94925 | 79361544 |
Syncope | 17.50 | 9.81 | 804 | 287115 | 178645 | 79277824 |
Blood creatine phosphokinase abnormal | 17.40 | 9.81 | 14 | 287905 | 450 | 79456019 |
Prostatic specific antigen increased | 17.37 | 9.81 | 79 | 287840 | 10307 | 79446162 |
Hypereosinophilic syndrome | 17.36 | 9.81 | 15 | 287904 | 533 | 79455936 |
Needle issue | 17.29 | 9.81 | 93 | 287826 | 12975 | 79443494 |
Serum procollagen type I N-terminal propeptide increased | 17.29 | 9.81 | 6 | 287913 | 29 | 79456440 |
Atrial enlargement | 17.16 | 9.81 | 20 | 287899 | 1023 | 79455446 |
Right atrial enlargement | 17.16 | 9.81 | 13 | 287906 | 382 | 79456087 |
Skin exfoliation | 17.13 | 9.81 | 287 | 287632 | 54813 | 79401656 |
Personality disorder | 17.11 | 9.81 | 55 | 287864 | 6091 | 79450378 |
Osteonecrosis of jaw | 17.09 | 9.81 | 89 | 287830 | 43137 | 79413332 |
Haematocrit increased | 17.05 | 9.81 | 42 | 287877 | 3992 | 79452477 |
Unwanted awareness during anaesthesia | 17.04 | 9.81 | 12 | 287907 | 314 | 79456155 |
Renal cyst | 16.96 | 9.81 | 101 | 287818 | 14631 | 79441838 |
Decubitus ulcer | 16.89 | 9.81 | 19 | 287900 | 15668 | 79440801 |
Sensory loss | 16.89 | 9.81 | 92 | 287827 | 12899 | 79443570 |
Sinonasal obstruction | 16.84 | 9.81 | 12 | 287907 | 320 | 79456149 |
Vascular device infection | 16.83 | 9.81 | 8 | 287911 | 10268 | 79446201 |
Blood urine present | 16.77 | 9.81 | 133 | 287786 | 21164 | 79435305 |
Catarrh | 16.71 | 9.81 | 29 | 287890 | 2149 | 79454320 |
Body temperature increased | 16.71 | 9.81 | 93 | 287826 | 44327 | 79412142 |
Hepatitis E antibody positive | 16.71 | 9.81 | 11 | 287908 | 257 | 79456212 |
Sputum discoloured | 16.70 | 9.81 | 135 | 287784 | 21608 | 79434861 |
Paraplegia | 16.68 | 9.81 | 48 | 287871 | 5005 | 79451464 |
Diabetic foot | 16.62 | 9.81 | 39 | 287880 | 3593 | 79452876 |
Heart rate decreased | 16.60 | 9.81 | 351 | 287568 | 69965 | 79386504 |
Metastases to bone | 16.57 | 9.81 | 40 | 287879 | 24387 | 79432082 |
Systolic dysfunction | 16.56 | 9.81 | 40 | 287879 | 3755 | 79452714 |
Nocturia | 16.53 | 9.81 | 95 | 287824 | 13586 | 79442883 |
Total cholesterol/HDL ratio increased | 16.52 | 9.81 | 11 | 287908 | 262 | 79456207 |
Helicobacter test false negative | 16.50 | 9.81 | 7 | 287912 | 63 | 79456406 |
Drug-disease interaction | 16.49 | 9.81 | 20 | 287899 | 1067 | 79455402 |
Pertussis | 16.48 | 9.81 | 18 | 287901 | 857 | 79455612 |
Paradoxical drug reaction | 16.47 | 9.81 | 3 | 287916 | 7182 | 79449287 |
Psychomotor hyperactivity | 16.46 | 9.81 | 22 | 287897 | 16827 | 79439642 |
Nipple disorder | 16.38 | 9.81 | 10 | 287909 | 204 | 79456265 |
Very low density lipoprotein increased | 16.34 | 9.81 | 10 | 287909 | 205 | 79456264 |
Meningitis eosinophilic | 16.26 | 9.81 | 5 | 287914 | 15 | 79456454 |
Cardiovascular somatic symptom disorder | 16.22 | 9.81 | 6 | 287913 | 36 | 79456433 |
Product residue present | 16.22 | 9.81 | 38 | 287881 | 3498 | 79452971 |
No adverse event | 16.19 | 9.81 | 74 | 287845 | 37118 | 79419351 |
Sensorimotor disorder | 16.16 | 9.81 | 18 | 287901 | 876 | 79455593 |
Oesophageal carcinoma | 16.15 | 9.81 | 10 | 287909 | 11074 | 79445395 |
Decreased ventricular preload | 16.08 | 9.81 | 6 | 287913 | 37 | 79456432 |
Skin toxicity | 16.06 | 9.81 | 5 | 287914 | 8309 | 79448160 |
Staphylococcal infection | 15.98 | 9.81 | 134 | 287785 | 58161 | 79398308 |
Myelodysplastic syndrome | 15.91 | 9.81 | 56 | 287863 | 30245 | 79426224 |
Brain oedema | 15.88 | 9.81 | 43 | 287876 | 25220 | 79431249 |
Infusion site streaking | 15.82 | 9.81 | 14 | 287905 | 514 | 79455955 |
Toxic shock syndrome | 15.82 | 9.81 | 21 | 287898 | 1228 | 79455241 |
Blood immunoglobulin G increased | 15.81 | 9.81 | 34 | 287885 | 2955 | 79453514 |
AST/ALT ratio abnormal | 15.79 | 9.81 | 5 | 287914 | 17 | 79456452 |
Encephalitis | 15.76 | 9.81 | 18 | 287901 | 14742 | 79441727 |
Granulocytopenia | 15.73 | 9.81 | 11 | 287908 | 11420 | 79445049 |
Muscle contractions involuntary | 15.70 | 9.81 | 39 | 287880 | 3726 | 79452743 |
Hepatitis E virus test positive | 15.68 | 9.81 | 11 | 287908 | 286 | 79456183 |
Blood thyroid stimulating hormone increased | 15.61 | 9.81 | 73 | 287846 | 9635 | 79446834 |
Respiratory distress | 15.59 | 9.81 | 135 | 287784 | 58204 | 79398265 |
Rhinorrhoea | 15.52 | 9.81 | 372 | 287547 | 75702 | 79380767 |
Prostatic haemorrhage | 15.49 | 9.81 | 9 | 287910 | 167 | 79456302 |
Cardiac murmur | 15.43 | 9.81 | 104 | 287815 | 15720 | 79440749 |
Drug tolerance | 15.41 | 9.81 | 6 | 287913 | 8669 | 79447800 |
Swelling of eyelid | 15.39 | 9.81 | 39 | 287880 | 3772 | 79452697 |
Hernia | 15.39 | 9.81 | 110 | 287809 | 16949 | 79439520 |
Drug use disorder | 15.34 | 9.81 | 6 | 287913 | 8645 | 79447824 |
Lethargy | 15.31 | 9.81 | 204 | 287715 | 81088 | 79375381 |
Endometriosis | 15.30 | 9.81 | 38 | 287881 | 3630 | 79452839 |
Left ventricular dysfunction | 15.30 | 9.81 | 121 | 287798 | 19240 | 79437229 |
Kidney transplant rejection | 15.27 | 9.81 | 9 | 287910 | 10237 | 79446232 |
Plasma cell myeloma | 15.25 | 9.81 | 121 | 287798 | 53138 | 79403331 |
Movement disorder | 15.22 | 9.81 | 158 | 287761 | 27101 | 79429368 |
Escherichia infection | 15.21 | 9.81 | 26 | 287893 | 17991 | 79438478 |
Tryptase increased | 15.11 | 9.81 | 15 | 287904 | 638 | 79455831 |
Deep vein thrombosis | 15.09 | 9.81 | 327 | 287592 | 120592 | 79335877 |
Complication associated with device | 15.00 | 9.81 | 25 | 287894 | 17471 | 79438998 |
Cataract operation | 14.99 | 9.81 | 47 | 287872 | 5138 | 79451331 |
Palmar-plantar erythrodysaesthesia syndrome | 14.99 | 9.81 | 65 | 287854 | 33069 | 79423400 |
Oxygen saturation increased | 14.96 | 9.81 | 14 | 287905 | 553 | 79455916 |
Nodular rash | 14.91 | 9.81 | 11 | 287908 | 310 | 79456159 |
Polymyalgia rheumatica | 14.88 | 9.81 | 43 | 287876 | 4494 | 79451975 |
Klebsiella infection | 14.88 | 9.81 | 21 | 287898 | 15699 | 79440770 |
Respiratory tract congestion | 14.84 | 9.81 | 123 | 287796 | 19831 | 79436638 |
Suspected suicide | 14.79 | 9.81 | 10 | 287909 | 10566 | 79445903 |
Right ventricular failure | 14.77 | 9.81 | 40 | 287879 | 23457 | 79433012 |
Hypocholesterolaemia | 14.72 | 9.81 | 9 | 287910 | 184 | 79456285 |
Hypogammaglobulinaemia | 14.71 | 9.81 | 15 | 287904 | 12936 | 79443533 |
Ligament pain | 14.67 | 9.81 | 10 | 287909 | 248 | 79456221 |
Prinzmetal angina | 14.66 | 9.81 | 24 | 287895 | 1696 | 79454773 |
Melanoderma | 14.59 | 9.81 | 12 | 287907 | 398 | 79456071 |
Non-alcoholic steatohepatitis | 14.58 | 9.81 | 28 | 287891 | 2244 | 79454225 |
Hepatotoxicity | 14.55 | 9.81 | 117 | 287802 | 51235 | 79405234 |
Apolipoprotein A-I decreased | 14.44 | 9.81 | 5 | 287914 | 24 | 79456445 |
Lymphopenia | 14.40 | 9.81 | 59 | 287860 | 30498 | 79425971 |
Atrial thrombosis | 14.34 | 9.81 | 37 | 287882 | 3619 | 79452850 |
Coeliac disease | 14.25 | 9.81 | 12 | 287907 | 11339 | 79445130 |
Oedema genital | 14.17 | 9.81 | 14 | 287905 | 592 | 79455877 |
Carnitine palmitoyltransferase deficiency | 14.15 | 9.81 | 4 | 287915 | 8 | 79456461 |
Medication error | 14.14 | 9.81 | 169 | 287750 | 68473 | 79387996 |
Loss of personal independence in daily activities | 14.08 | 9.81 | 477 | 287442 | 102103 | 79354366 |
Listless | 14.05 | 9.81 | 38 | 287881 | 3823 | 79452646 |
Pre-eclampsia | 14.03 | 9.81 | 4 | 287915 | 7037 | 79449432 |
Thyroid disorder | 14.01 | 9.81 | 93 | 287826 | 13986 | 79442483 |
High density lipoprotein increased | 14.00 | 9.81 | 19 | 287900 | 1135 | 79455334 |
Lymphomatoid papulosis | 13.98 | 9.81 | 11 | 287908 | 342 | 79456127 |
Pemphigoid | 13.96 | 9.81 | 99 | 287820 | 15216 | 79441253 |
Abscess of salivary gland | 13.95 | 9.81 | 5 | 287914 | 27 | 79456442 |
Injection site hypersensitivity | 13.95 | 9.81 | 25 | 287894 | 1900 | 79454569 |
Lichen planus | 13.91 | 9.81 | 31 | 287888 | 2760 | 79453709 |
Epstein-Barr virus infection | 13.90 | 9.81 | 19 | 287900 | 14397 | 79442072 |
Bacteraemia | 13.88 | 9.81 | 66 | 287853 | 32758 | 79423711 |
Histamine level increased | 13.85 | 9.81 | 7 | 287912 | 97 | 79456372 |
Malignant melanoma | 13.85 | 9.81 | 96 | 287823 | 14645 | 79441824 |
Conjunctivitis | 13.85 | 9.81 | 47 | 287872 | 25668 | 79430801 |
Blood pressure diastolic increased | 13.84 | 9.81 | 95 | 287824 | 14447 | 79442022 |
Flatulence | 13.82 | 9.81 | 224 | 287695 | 42500 | 79413969 |
Gastrointestinal toxicity | 13.77 | 9.81 | 6 | 287913 | 8103 | 79448366 |
Infrequent bowel movements | 13.73 | 9.81 | 23 | 287896 | 1656 | 79454813 |
Exposure to toxic agent | 13.71 | 9.81 | 8 | 287911 | 9150 | 79447319 |
Transcription medication error | 13.64 | 9.81 | 12 | 287907 | 437 | 79456032 |
Clostridium difficile colitis | 13.60 | 9.81 | 65 | 287854 | 32218 | 79424251 |
Loss of control of legs | 13.58 | 9.81 | 25 | 287894 | 1940 | 79454529 |
Presyncope | 13.57 | 9.81 | 216 | 287703 | 40838 | 79415631 |
Food interaction | 13.50 | 9.81 | 23 | 287896 | 1679 | 79454790 |
Mesenteric artery thrombosis | 13.50 | 9.81 | 14 | 287905 | 628 | 79455841 |
Tendon pain | 13.44 | 9.81 | 48 | 287871 | 5610 | 79450859 |
Sputum culture | 13.42 | 9.81 | 9 | 287910 | 217 | 79456252 |
Arterial spasm | 13.42 | 9.81 | 8 | 287911 | 156 | 79456313 |
Ureteric cancer | 13.40 | 9.81 | 10 | 287909 | 287 | 79456182 |
Oxygen consumption decreased | 13.39 | 9.81 | 12 | 287907 | 448 | 79456021 |
Peripheral venous disease | 13.39 | 9.81 | 23 | 287896 | 15886 | 79440583 |
Left atrial enlargement | 13.38 | 9.81 | 19 | 287900 | 1184 | 79455285 |
Arthralgia | 13.37 | 9.81 | 2303 | 285616 | 569500 | 78886969 |
Hypopnoea | 13.34 | 9.81 | 46 | 287873 | 5283 | 79451186 |
Transaminases abnormal | 13.31 | 9.81 | 16 | 287903 | 846 | 79455623 |
Peripheral artery restenosis | 13.26 | 9.81 | 4 | 287915 | 11 | 79456458 |
Clitoris abscess | 13.26 | 9.81 | 4 | 287915 | 11 | 79456458 |
Blood pressure ambulatory increased | 13.26 | 9.81 | 6 | 287913 | 64 | 79456405 |
Cardiac autonomic neuropathy | 13.26 | 9.81 | 6 | 287913 | 64 | 79456405 |
Injection site bruising | 13.26 | 9.81 | 90 | 287829 | 40912 | 79415557 |
Electrocardiogram QT prolonged | 13.23 | 9.81 | 238 | 287681 | 90148 | 79366321 |
Nephrolithiasis | 13.23 | 9.81 | 268 | 287651 | 53023 | 79403446 |
Myoglobinuria | 13.17 | 9.81 | 18 | 287901 | 1082 | 79455387 |
Hepatic cirrhosis | 13.17 | 9.81 | 73 | 287846 | 34833 | 79421636 |
Left ventricular dilatation | 13.16 | 9.81 | 18 | 287901 | 1083 | 79455386 |
Metastases to liver | 13.14 | 9.81 | 55 | 287864 | 28259 | 79428210 |
Chronic spontaneous urticaria | 13.13 | 9.81 | 19 | 287900 | 1205 | 79455264 |
Base excess decreased | 13.12 | 9.81 | 11 | 287908 | 375 | 79456094 |
Mania | 13.11 | 9.81 | 29 | 287890 | 18231 | 79438238 |
Haemorrhagic cerebral infarction | 13.10 | 9.81 | 21 | 287898 | 1458 | 79455011 |
Haemorrhagic diathesis | 13.09 | 9.81 | 50 | 287869 | 6034 | 79450435 |
Chronic cutaneous lupus erythematosus | 13.08 | 9.81 | 12 | 287907 | 462 | 79456007 |
Bronchopulmonary aspergillosis allergic | 13.07 | 9.81 | 32 | 287887 | 3029 | 79453440 |
Injection site swelling | 13.07 | 9.81 | 108 | 287811 | 47024 | 79409445 |
Parkinsonism | 13.04 | 9.81 | 25 | 287894 | 16559 | 79439910 |
Premature labour | 13.04 | 9.81 | 7 | 287912 | 8383 | 79448086 |
Hyperreflexia | 13.02 | 9.81 | 7 | 287912 | 8378 | 79448091 |
Amylase increased | 13.00 | 9.81 | 77 | 287842 | 11132 | 79445337 |
Breast cancer stage I | 12.99 | 9.81 | 4 | 287915 | 6696 | 79449773 |
Vertebrobasilar insufficiency | 12.99 | 9.81 | 10 | 287909 | 301 | 79456168 |
Sinus disorder | 12.92 | 9.81 | 131 | 287788 | 22333 | 79434136 |
Electrocardiogram abnormal | 12.90 | 9.81 | 104 | 287815 | 16633 | 79439836 |
Bradypnoea | 12.90 | 9.81 | 3 | 287916 | 6049 | 79450420 |
Herpes simplex | 12.86 | 9.81 | 15 | 287904 | 12172 | 79444297 |
Basophil count increased | 12.84 | 9.81 | 21 | 287898 | 1482 | 79454987 |
Extrasystoles | 12.83 | 9.81 | 57 | 287862 | 7362 | 79449107 |
Hypercreatinaemia | 12.79 | 9.81 | 10 | 287909 | 308 | 79456161 |
Diabetic nephropathy | 12.79 | 9.81 | 31 | 287888 | 2916 | 79453553 |
Head discomfort | 12.79 | 9.81 | 93 | 287826 | 14409 | 79442060 |
BK virus infection | 12.75 | 9.81 | 8 | 287911 | 8796 | 79447673 |
Female genital tract fistula | 12.66 | 9.81 | 3 | 287916 | 5972 | 79450497 |
Hepatic steatosis | 12.64 | 9.81 | 199 | 287720 | 37539 | 79418930 |
Retroperitoneal fibrosis | 12.61 | 9.81 | 14 | 287905 | 679 | 79455790 |
Arthritis | 12.59 | 9.81 | 521 | 287398 | 114359 | 79342110 |
Microalbuminuria | 12.50 | 9.81 | 16 | 287903 | 902 | 79455567 |
Abortion induced | 12.49 | 9.81 | 5 | 287914 | 7104 | 79449365 |
Degenerative bone disease | 12.49 | 9.81 | 7 | 287912 | 121 | 79456348 |
Acute hepatic failure | 12.47 | 9.81 | 61 | 287858 | 30052 | 79426417 |
Aldolase increased | 12.47 | 9.81 | 9 | 287910 | 245 | 79456224 |
Sinus tachycardia | 12.44 | 9.81 | 80 | 287839 | 36828 | 79419641 |
Pruritus | 12.34 | 9.81 | 1616 | 286303 | 393032 | 79063437 |
Skin test negative | 12.30 | 9.81 | 5 | 287914 | 40 | 79456429 |
Electrocardiogram ambulatory abnormal | 12.30 | 9.81 | 5 | 287914 | 40 | 79456429 |
Blood creatine phosphokinase MM increased | 12.30 | 9.81 | 5 | 287914 | 40 | 79456429 |
Degenerative aortic valve disease | 12.26 | 9.81 | 8 | 287911 | 184 | 79456285 |
Nightmare | 12.20 | 9.81 | 145 | 287774 | 25716 | 79430753 |
Hypomania | 12.16 | 9.81 | 6 | 287913 | 7538 | 79448931 |
X-ray abnormal | 12.15 | 9.81 | 3 | 287916 | 5810 | 79450659 |
Motor dysfunction | 12.15 | 9.81 | 93 | 287826 | 14640 | 79441829 |
Coma acidotic | 12.14 | 9.81 | 7 | 287912 | 128 | 79456341 |
Erythema marginatum | 12.13 | 9.81 | 4 | 287915 | 16 | 79456453 |
Hypercalcaemia | 12.10 | 9.81 | 85 | 287834 | 38345 | 79418124 |
Cardiac disorder | 12.07 | 9.81 | 317 | 287602 | 65440 | 79391029 |
Eructation | 12.06 | 9.81 | 74 | 287845 | 10835 | 79445634 |
Normocytic anaemia | 12.04 | 9.81 | 38 | 287881 | 4169 | 79452300 |
Hypertriglyceridaemia | 11.99 | 9.81 | 83 | 287836 | 12657 | 79443812 |
Anuria | 11.94 | 9.81 | 122 | 287797 | 20841 | 79435628 |
Red cell distribution width increased | 11.90 | 9.81 | 95 | 287824 | 15147 | 79441322 |
Electrocardiogram QRS complex abnormal | 11.87 | 9.81 | 13 | 287906 | 621 | 79455848 |
Psoriatic arthropathy | 11.85 | 9.81 | 204 | 287715 | 77795 | 79378674 |
Platelet count decreased | 11.84 | 9.81 | 578 | 287341 | 194086 | 79262383 |
Potentiating drug interaction | 11.83 | 9.81 | 63 | 287856 | 8756 | 79447713 |
Multiple drug therapy | 11.82 | 9.81 | 37 | 287882 | 4041 | 79452428 |
Neurotrophic keratopathy | 11.81 | 9.81 | 3 | 287916 | 3 | 79456466 |
Cardiac valve fibroelastoma | 11.81 | 9.81 | 3 | 287916 | 3 | 79456466 |
Confusional state | 11.77 | 9.81 | 988 | 286931 | 317009 | 79139460 |
Diffuse alopecia | 11.77 | 9.81 | 16 | 287903 | 957 | 79455512 |
Sinus rhythm | 11.76 | 9.81 | 15 | 287904 | 843 | 79455626 |
Breast pain | 11.75 | 9.81 | 60 | 287859 | 8205 | 79448264 |
Malaise | 11.67 | 9.81 | 1975 | 285944 | 487894 | 78968575 |
Gamma-glutamyltransferase increased | 11.65 | 9.81 | 269 | 287650 | 54411 | 79402058 |
Rotator cuff syndrome | 11.64 | 9.81 | 89 | 287830 | 14006 | 79442463 |
Cyanosis | 11.63 | 9.81 | 49 | 287870 | 25133 | 79431336 |
Pulmonary tuberculosis | 11.60 | 9.81 | 7 | 287912 | 7858 | 79448611 |
Respiratory acidosis | 11.59 | 9.81 | 14 | 287905 | 11186 | 79445283 |
Liver function test increased | 11.58 | 9.81 | 205 | 287714 | 39568 | 79416901 |
Immunodeficiency | 11.58 | 9.81 | 40 | 287879 | 21728 | 79434741 |
Blood immunoglobulin M increased | 11.56 | 9.81 | 19 | 287900 | 1347 | 79455122 |
Lung opacity | 11.53 | 9.81 | 43 | 287876 | 5131 | 79451338 |
Flushing | 11.51 | 9.81 | 237 | 287682 | 88031 | 79368438 |
Streptococcal infection | 11.50 | 9.81 | 9 | 287910 | 8821 | 79447648 |
Thalamus haemorrhage | 11.48 | 9.81 | 22 | 287897 | 1760 | 79454709 |
Electrolyte imbalance | 11.43 | 9.81 | 65 | 287854 | 30816 | 79425653 |
Psychotic disorder | 11.42 | 9.81 | 95 | 287824 | 41307 | 79415162 |
Impaired quality of life | 11.42 | 9.81 | 90 | 287829 | 14296 | 79442173 |
Episcleral venous pressure increased | 11.42 | 9.81 | 4 | 287915 | 20 | 79456449 |
Toxic cataract | 11.42 | 9.81 | 4 | 287915 | 20 | 79456449 |
Pleuritic pain | 11.26 | 9.81 | 12 | 287907 | 10140 | 79446329 |
Hepatitis B reactivation | 11.23 | 9.81 | 4 | 287915 | 6104 | 79450365 |
Hyperplastic cholecystopathy | 11.18 | 9.81 | 8 | 287911 | 215 | 79456254 |
Mitral valve disease | 11.17 | 9.81 | 31 | 287888 | 3166 | 79453303 |
Tardive dyskinesia | 11.17 | 9.81 | 13 | 287906 | 10558 | 79445911 |
Urine albumin/creatinine ratio increased | 11.16 | 9.81 | 12 | 287907 | 561 | 79455908 |
Hepatosplenomegaly | 11.11 | 9.81 | 4 | 287915 | 6065 | 79450404 |
Arcus lipoides | 11.10 | 9.81 | 4 | 287915 | 22 | 79456447 |
Ventricular arrhythmia | 11.09 | 9.81 | 62 | 287857 | 8778 | 79447691 |
Respiratory disorder | 11.03 | 9.81 | 106 | 287813 | 44750 | 79411719 |
Colorectal cancer | 11.03 | 9.81 | 9 | 287910 | 8638 | 79447831 |
Creatinine renal clearance increased | 11.03 | 9.81 | 15 | 287904 | 898 | 79455571 |
Hepatic failure | 11.03 | 9.81 | 155 | 287764 | 61057 | 79395412 |
Lichenoid keratosis | 11.02 | 9.81 | 36 | 287883 | 4021 | 79452448 |
Unevaluable event | 11.02 | 9.81 | 138 | 287781 | 55447 | 79401022 |
Hepatic enzyme increased | 10.95 | 9.81 | 543 | 287376 | 182067 | 79274402 |
Bursitis | 10.94 | 9.81 | 80 | 287839 | 35764 | 79420705 |
Tenosynovitis | 10.93 | 9.81 | 25 | 287894 | 15529 | 79440940 |
Eye disorder | 10.92 | 9.81 | 131 | 287788 | 23281 | 79433188 |
Blood triglycerides decreased | 10.92 | 9.81 | 8 | 287911 | 223 | 79456246 |
High density lipoprotein abnormal | 10.92 | 9.81 | 7 | 287912 | 156 | 79456313 |
Hypochromasia | 10.88 | 9.81 | 13 | 287906 | 683 | 79455786 |
Essential hypertension | 10.85 | 9.81 | 47 | 287872 | 6006 | 79450463 |
Neoplasm | 10.82 | 9.81 | 63 | 287856 | 9053 | 79447416 |
Neuropathy peripheral | 10.79 | 9.81 | 409 | 287510 | 140896 | 79315573 |
Pericardial fibrosis | 10.77 | 9.81 | 7 | 287912 | 160 | 79456309 |
Therapeutic response decreased | 10.76 | 9.81 | 173 | 287746 | 66680 | 79389789 |
Maternal condition affecting foetus | 10.73 | 9.81 | 7 | 287912 | 161 | 79456308 |
Pseudomonas infection | 10.73 | 9.81 | 39 | 287880 | 20864 | 79435605 |
Drug specific antibody | 10.73 | 9.81 | 27 | 287892 | 2601 | 79453868 |
Apnoea | 10.72 | 9.81 | 16 | 287903 | 11688 | 79444781 |
Steroid dependence | 10.71 | 9.81 | 27 | 287892 | 2603 | 79453866 |
Blood immunoglobulin A decreased | 10.70 | 9.81 | 19 | 287900 | 1434 | 79455035 |
Hyperkeratosis | 10.69 | 9.81 | 56 | 287863 | 7734 | 79448735 |
Expired product administered | 10.60 | 9.81 | 52 | 287867 | 6999 | 79449470 |
Myoglobin urine present | 10.60 | 9.81 | 15 | 287904 | 932 | 79455537 |
Hospitalisation | 10.59 | 9.81 | 259 | 287660 | 93977 | 79362492 |
Intensive care | 10.52 | 9.81 | 16 | 287903 | 1061 | 79455408 |
Angiopathy | 10.48 | 9.81 | 52 | 287867 | 7030 | 79449439 |
Prostatomegaly | 10.46 | 9.81 | 32 | 287887 | 3451 | 79453018 |
Immune effector cell-associated neurotoxicity syndrome | 10.46 | 9.81 | 4 | 287915 | 5844 | 79450625 |
Feeding disorder | 10.43 | 9.81 | 97 | 287822 | 16157 | 79440312 |
Renal impairment | 10.43 | 9.81 | 682 | 287237 | 157101 | 79299368 |
Infective spondylitis | 10.43 | 9.81 | 11 | 287908 | 503 | 79455966 |
Road traffic accident | 10.39 | 9.81 | 104 | 287815 | 43560 | 79412909 |
Noninfective encephalitis | 10.37 | 9.81 | 12 | 287907 | 609 | 79455860 |
Vaginal haemorrhage | 10.36 | 9.81 | 42 | 287877 | 21775 | 79434694 |
Complications of transplanted kidney | 10.36 | 9.81 | 5 | 287914 | 6361 | 79450108 |
Complication of device insertion | 10.31 | 9.81 | 5 | 287914 | 6345 | 79450124 |
Blood growth hormone increased | 10.30 | 9.81 | 13 | 287906 | 723 | 79455746 |
Contraindication to surgery | 10.30 | 9.81 | 3 | 287916 | 7 | 79456462 |
Angiogram | 10.25 | 9.81 | 6 | 287913 | 113 | 79456356 |
Strangulated hernia | 10.25 | 9.81 | 5 | 287914 | 64 | 79456405 |
Nervous system disorder | 10.22 | 9.81 | 56 | 287863 | 26800 | 79429669 |
Pneumonia aspiration | 10.22 | 9.81 | 175 | 287744 | 66792 | 79389677 |
Pulmonary arterial pressure abnormal | 10.21 | 9.81 | 13 | 287906 | 729 | 79455740 |
Blood loss anaemia | 10.21 | 9.81 | 93 | 287826 | 15405 | 79441064 |
Liver function test abnormal | 10.20 | 9.81 | 305 | 287614 | 64170 | 79392299 |
Metastases to central nervous system | 10.20 | 9.81 | 28 | 287891 | 16347 | 79440122 |
Multiple sclerosis relapse | 10.20 | 9.81 | 113 | 287806 | 46420 | 79410049 |
Diabetic neuropathy | 10.19 | 9.81 | 47 | 287872 | 6169 | 79450300 |
Cerebral haematoma | 10.16 | 9.81 | 56 | 287863 | 7886 | 79448583 |
Oedema mouth | 10.09 | 9.81 | 29 | 287890 | 3022 | 79453447 |
Atheroembolism | 10.07 | 9.81 | 9 | 287910 | 335 | 79456134 |
Urine ketone body present | 10.02 | 9.81 | 32 | 287887 | 3533 | 79452936 |
Procedural pain | 10.01 | 9.81 | 46 | 287873 | 23038 | 79433431 |
Campylobacter test positive | 9.98 | 9.81 | 5 | 287914 | 68 | 79456401 |
Acute respiratory failure | 9.95 | 9.81 | 153 | 287766 | 59388 | 79397081 |
Schizophrenia | 9.92 | 9.81 | 26 | 287893 | 15414 | 79441055 |
Coma scale abnormal | 9.91 | 9.81 | 10 | 287909 | 8668 | 79447801 |
Respiratory tract infection | 9.91 | 9.81 | 238 | 287681 | 48451 | 79408018 |
Mean cell haemoglobin increased | 9.88 | 9.81 | 36 | 287883 | 4249 | 79452220 |
Tonsillitis | 9.86 | 9.81 | 6 | 287913 | 6708 | 79449761 |
Reduced facial expression | 9.85 | 9.81 | 27 | 287892 | 2738 | 79453731 |
Diaphragm muscle weakness | 9.85 | 9.81 | 7 | 287912 | 186 | 79456283 |
Atelectasis | 9.84 | 9.81 | 72 | 287847 | 32185 | 79424284 |
Blood bicarbonate decreased | 9.84 | 9.81 | 41 | 287878 | 5150 | 79451319 |
Cushingoid | 9.82 | 9.81 | 12 | 287907 | 9540 | 79446929 |
Amenorrhoea | 9.82 | 9.81 | 8 | 287911 | 7684 | 79448785 |
Polyomavirus-associated nephropathy | 9.82 | 9.81 | 4 | 287915 | 5623 | 79450846 |
Vascular purpura | 9.81 | 9.81 | 29 | 287890 | 3069 | 79453400 |
Blood pressure abnormal | 9.81 | 9.81 | 100 | 287819 | 17069 | 79439400 |
None
Source | Code | Description |
---|---|---|
ATC | A10BH52 | ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS Dipeptidyl peptidase 4 (DPP-4) inhibitors |
ATC | C10AA07 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, PLAIN HMG CoA reductase inhibitors |
ATC | C10BA06 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Combinations of various lipid modifying agents |
ATC | C10BA07 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Combinations of various lipid modifying agents |
ATC | C10BA09 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Combinations of various lipid modifying agents |
ATC | C10BX05 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX07 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX09 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX10 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX13 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX14 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX16 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX17 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
FDA MoA | N0000000121 | Hydroxymethylglutaryl-CoA Reductase Inhibitors |
FDA EPC | N0000175589 | HMG-CoA Reductase Inhibitor |
MeSH PA | D000963 | Antimetabolites |
MeSH PA | D000924 | Anticholesteremic Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D019161 | Hydroxymethylglutaryl-CoA Reductase Inhibitors |
MeSH PA | D000960 | Hypolipidemic Agents |
MeSH PA | D057847 | Lipid Regulating Agents |
CHEBI has role | CHEBI:35679 | antilipemic drugs |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:49205 | CETP inhibitors |
CHEBI has role | CHEBI:67079 | anti-inflammatory agents |
CHEBI has role | CHEBI:77307 | cardioprotective agents |
CHEBI has role | CHEBI:78298 | environmental contaminants |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Hypercholesterolemia | indication | 13644009 | |
Arteriosclerotic vascular disease | indication | 72092001 | |
Cerebrovascular accident | indication | 230690007 | |
Familial hypercholesterolemia - homozygous | indication | 238078005 | |
Familial hypercholesterolemia - heterozygous | indication | 238079002 | |
Mixed hyperlipidemia | indication | 267434003 | |
Hypertriglyceridemia | indication | 302870006 | |
Familial type 3 hyperlipoproteinemia | indication | 398796005 | DOID:3145 |
Prevention of Transient Ischemic Attacks | indication | ||
Primary Prevention of Coronary Heart Disease | indication | ||
Myocardial Infarction Prevention | indication | ||
Alcoholism | contraindication | 7200002 | |
Proteinuria | contraindication | 29738008 | DOID:576 |
Dehydration | contraindication | 34095006 | |
Blood in urine | contraindication | 34436003 | |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Acute nephropathy | contraindication | 58574008 | |
Disorder of muscle | contraindication | 129565002 | DOID:423 |
Liver function tests abnormal | contraindication | 166603001 | |
Hemorrhagic cerebral infarction | contraindication | 230706003 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Rhabdomyolysis | contraindication | 240131006 | |
Pregnancy, function | contraindication | 289908002 | |
Surgical procedure | contraindication | 387713003 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Traumatic injury | contraindication | 417746004 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.29 | acidic |
pKa2 | 13.84 | acidic |
pKa3 | 3.67 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
10MG;EQ 10MG BASE | ROSZET | ALTHERA PHARMS | N213072 | March 23, 2021 | DISCN | TABLET | ORAL | 10376470 | May 1, 2033 | TREATMENT OF HYPERLIPIDEMIA |
10MG;EQ 10MG BASE | ROSZET | ALTHERA PHARMS | N213072 | March 23, 2021 | DISCN | TABLET | ORAL | 9763885 | May 1, 2033 | TREATMENT OF HYPERLIPIDEMIA |
10MG;EQ 20MG BASE | ROSZET | ALTHERA PHARMS | N213072 | March 23, 2021 | DISCN | TABLET | ORAL | 10376470 | May 1, 2033 | TREATMENT OF HYPERLIPIDEMIA |
10MG;EQ 20MG BASE | ROSZET | ALTHERA PHARMS | N213072 | March 23, 2021 | DISCN | TABLET | ORAL | 9763885 | May 1, 2033 | TREATMENT OF HYPERLIPIDEMIA |
10MG;EQ 40MG BASE | ROSZET | ALTHERA PHARMS | N213072 | March 23, 2021 | DISCN | TABLET | ORAL | 10376470 | May 1, 2033 | TREATMENT OF HYPERLIPIDEMIA |
10MG;EQ 40MG BASE | ROSZET | ALTHERA PHARMS | N213072 | March 23, 2021 | DISCN | TABLET | ORAL | 9763885 | May 1, 2033 | TREATMENT OF HYPERLIPIDEMIA |
10MG;EQ 5MG BASE | ROSZET | ALTHERA PHARMS | N213072 | March 23, 2021 | DISCN | TABLET | ORAL | 10376470 | May 1, 2033 | TREATMENT OF HYPERLIPIDEMIA |
10MG;EQ 5MG BASE | ROSZET | ALTHERA PHARMS | N213072 | March 23, 2021 | DISCN | TABLET | ORAL | 9763885 | May 1, 2033 | TREATMENT OF HYPERLIPIDEMIA |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
EQ 10MG BASE | CRESTOR | IPR | N021366 | Aug. 12, 2003 | RX | TABLET | ORAL | May 27, 2023 | AN ADJUNCT TO DIET TO REDUCE LDL-C, TOTAL-C, NONHDL-C AND APOB IN CHILDREN AND ADOLESCENTS 7 TO 17 YEARS OF AGE WITH HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA, EITHER ALONE OR WITH OTHER LIPID-LOWERING TREATMENTS (E.G., LDL APHERESIS) |
EQ 20MG BASE | CRESTOR | IPR | N021366 | Aug. 12, 2003 | RX | TABLET | ORAL | May 27, 2023 | AN ADJUNCT TO DIET TO REDUCE LDL-C, TOTAL-C, NONHDL-C AND APOB IN CHILDREN AND ADOLESCENTS 7 TO 17 YEARS OF AGE WITH HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA, EITHER ALONE OR WITH OTHER LIPID-LOWERING TREATMENTS (E.G., LDL APHERESIS) |
EQ 40MG BASE | CRESTOR | IPR | N021366 | Aug. 12, 2003 | RX | TABLET | ORAL | May 27, 2023 | AN ADJUNCT TO DIET TO REDUCE LDL-C, TOTAL-C, NONHDL-C AND APOB IN CHILDREN AND ADOLESCENTS 7 TO 17 YEARS OF AGE WITH HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA, EITHER ALONE OR WITH OTHER LIPID-LOWERING TREATMENTS (E.G., LDL APHERESIS) |
EQ 5MG BASE | CRESTOR | IPR | N021366 | Aug. 12, 2003 | RX | TABLET | ORAL | May 27, 2023 | AN ADJUNCT TO DIET TO REDUCE LDL-C, TOTAL-C, NONHDL-C AND APOB IN CHILDREN AND ADOLESCENTS 7 TO 17 YEARS OF AGE WITH HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA, EITHER ALONE OR WITH OTHER LIPID-LOWERING TREATMENTS (E.G., LDL APHERESIS) |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
3-hydroxy-3-methylglutaryl-coenzyme A reductase | Enzyme | INHIBITOR | Ki | 9.05 | CHEMBL | CHEMBL | |||
Phosphodiesterase 6D | Enzyme | Kd | 5.90 | CHEMBL | |||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase | Enzyme | IC50 | 8.68 | CHEMBL |
ID | Source |
---|---|
4021405 | VUID |
N0000148821 | NUI |
D01915 | KEGG_DRUG |
147098-20-2 | SECONDARY_CAS_RN |
4021405 | VANDF |
C0965129 | UMLSCUI |
CHEBI:38545 | CHEBI |
FBI | PDB_CHEM_ID |
CHEMBL1496 | ChEMBL_ID |
CHEMBL1744447 | ChEMBL_ID |
D000068718 | MESH_DESCRIPTOR_UI |
DB01098 | DRUGBANK_ID |
2954 | IUPHAR_LIGAND_ID |
8021 | INN_ID |
953412-08-3 | SECONDARY_CAS_RN |
413KH5ZJ73 | UNII |
446157 | PUBCHEM_CID |
301542 | RXNORM |
107656 | MMSL |
17146 | MMSL |
17536 | MMSL |
34243 | MMSL |
46321 | MMSL |
d04851 | MMSL |
009902 | NDDF |
009903 | NDDF |
019242 | NDDF |
1217216007 | SNOMEDCT_US |
406435003 | SNOMEDCT_US |
700067006 | SNOMEDCT_US |
768151007 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
CRESTOR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-0751 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 27 sections |
CRESTOR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-0751 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 27 sections |
CRESTOR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-0751 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 27 sections |
CRESTOR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-0752 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 27 sections |
CRESTOR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-0752 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 27 sections |
CRESTOR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-0752 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 27 sections |
CRESTOR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-0754 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 27 sections |
CRESTOR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-0754 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 27 sections |
CRESTOR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-0754 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 27 sections |
CRESTOR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-0755 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 27 sections |
CRESTOR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-0755 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 27 sections |
CRESTOR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-0755 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 27 sections |
Crestor | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-7560 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 29 sections |
Crestor | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-7560 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 29 sections |
Crestor | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-7570 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 29 sections |
Crestor | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-7570 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 29 sections |
Crestor | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-7580 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 29 sections |
Crestor | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-7580 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 29 sections |
Crestor | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-7580 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 29 sections |
Crestor | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-7590 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 29 sections |
Crestor | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-7590 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 29 sections |
Crestor | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0310-7590 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 29 sections |
Rosuvastatin calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5400 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 26 sections |
Rosuvastatin calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5401 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 26 sections |
Rosuvastatin calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5402 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 26 sections |
Rosuvastatin calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5403 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 26 sections |
Rosuvastatin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6778 | TABLET, COATED | 5 mg | ORAL | ANDA | 21 sections |
Rosuvastatin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6778 | TABLET, COATED | 5 mg | ORAL | ANDA | 21 sections |
Rosuvastatin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6779 | TABLET, COATED | 10 mg | ORAL | ANDA | 21 sections |
Rosuvastatin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6779 | TABLET, COATED | 10 mg | ORAL | ANDA | 21 sections |