ropinirole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	2402	91374-21-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: ropinirol requip ropinirole ropinirole hydrochloride ropinirole HCl	Ropinirole is a non-ergoline dopamine agonist. The precise mechanism of action of ropinirole as a treatment for Parkinson’s disease is unknown, although it is thought to be related to its ability to stimulate dopamine D2 receptors within the caudate-putamen in the brain. Molecular weight: 260.38 Formula: C16H24N2O CLOGP: 2.80 LIPINSKI: 0 HAC: 3 HDO: 1 TPSA: 32.34 ALOGS: -2.87 ROTB: 7 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

ropinirol
requip
ropinirole
ropinirole hydrochloride
ropinirole HCl

Ropinirole is a non-ergoline dopamine agonist. The precise mechanism of action of ropinirole as a treatment for Parkinson’s disease is unknown, although it is thought to be related to its ability to stimulate dopamine D2 receptors within the caudate-putamen in the brain.

Molecular weight: 260.38
Formula: C16H24N2O
CLOGP: 2.80
LIPINSKI: 0
HAC: 3
HDO: 1
TPSA: 32.34
ALOGS: -2.87
ROTB: 7

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
6	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	133 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	5 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	1.32 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	55 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	7.70 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	30 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.60 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	6 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Sept. 19, 1997	FDA	GLAXOSMITHKLINE LLC
Sept. 20, 2019	PMDA	Hisamitsu Pharmaceutical Co., Inc.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Dyskinesia	209.17	12.76	135	20786	27726	50556477
Compulsive shopping	191.39	12.76	47	20874	671	50583532
On and off phenomenon	168.72	12.76	49	20872	1363	50582840
Hallucination	165.14	12.76	144	20777	46513	50537690
Hallucination, visual	159.16	12.76	94	20827	16488	50567715
Dopamine dysregulation syndrome	150.75	12.76	30	20891	146	50584057
Restless legs syndrome	109.44	12.76	73	20848	15824	50568379
Impulse-control disorder	101.54	12.76	28	20893	642	50583561
Bradykinesia	80.18	12.76	37	20884	3906	50580297
Stoma site discharge	75.90	12.76	26	20895	1249	50582954
Fall	75.79	12.76	306	20615	334626	50249577
Freezing phenomenon	73.55	12.76	24	20897	991	50583212
Gait disturbance	72.02	12.76	178	20743	149827	50434376
Stoma site erythema	68.35	12.76	22	20899	869	50583334
Gambling	65.70	12.76	16	20905	220	50583983
Tremor	65.67	12.76	146	20775	114757	50469446
Gambling disorder	58.26	12.76	21	20900	1173	50583030
Hyperkinesia	57.84	12.76	22	20899	1430	50582773
Jealous delusion	54.07	12.76	10	20911	30	50584173
Parkinsonism hyperpyrexia syndrome	52.42	12.76	12	20909	124	50584079
Full blood count abnormal	48.60	12.76	54	20867	23334	50560869
Infusion related reaction	42.71	12.76	9	20912	169548	50414655
Delusion	42.22	12.76	35	20886	10534	50573669
Memory impairment	42.15	12.76	98	20823	79262	50504941
Illusion	39.90	12.76	15	20906	944	50583259
Insomnia	39.59	12.76	160	20761	174705	50409498
Product dose omission issue	39.10	12.76	165	20756	183673	50400530
Parkinsonian gait	38.40	12.76	12	20909	430	50583773
Hypersexuality	38.09	12.76	12	20909	442	50583761
Binge eating	35.42	12.76	11	20910	386	50583817
Stoma site pain	35.02	12.76	13	20908	790	50583413
Treatment failure	33.26	12.76	8	20913	137629	50446574
Psychotic symptom	33.13	12.76	14	20907	1198	50583005
Balance disorder	31.97	12.76	82	20839	70508	50513695
Joint swelling	31.47	12.76	33	20888	245253	50338950
Drug withdrawal syndrome	31.45	12.76	45	20876	25036	50559167
Exposure during pregnancy	31.35	12.76	6	20915	121009	50463194
Muscle spasms	30.92	12.76	118	20803	125435	50458768
Withdrawal syndrome	30.49	12.76	37	20884	17553	50566650
Oromandibular dystonia	30.25	12.76	10	20911	430	50583773
Muscle rigidity	30.12	12.76	28	20893	9801	50574402
Dystonia	29.12	12.76	30	20891	11896	50572307
Eczema eyelids	27.64	12.76	7	20914	114	50584089
Limbic encephalitis	27.45	12.76	8	20913	225	50583978
Glossodynia	27.37	12.76	7	20914	115562	50468641
Multiple sclerosis relapse	27.26	12.76	57	20864	42907	50541296
Systemic lupus erythematosus	27.25	12.76	12	20909	140610	50443593
Feeling abnormal	26.93	12.76	113	20808	125379	50458824
Mental impairment	25.35	12.76	28	20893	12016	50572187
Hyperglycaemia	25.11	12.76	50	20871	36355	50547848
Toxicity to various agents	24.64	12.76	31	20890	212468	50371735
Anxiety	24.54	12.76	141	20780	177465	50406738
Therapeutic response shortened	24.50	12.76	22	20899	7367	50576836
Gastrooesophageal reflux disease	24.13	12.76	78	20843	76350	50507853
Dizziness	23.82	12.76	233	20688	346136	50238067
Abnormal dreams	23.64	12.76	24	20897	9353	50574850
Stereotypy	23.56	12.76	8	20913	374	50583829
Hepatic enzyme increased	23.23	12.76	14	20907	137366	50446837
Posture abnormal	23.12	12.76	13	20908	2076	50582127
Pleurothotonus	22.74	12.76	11	20910	1290	50582913
Behaviour disorder	21.54	12.76	13	20908	2367	50581836
Therapeutic response unexpected	20.61	12.76	29	20892	15886	50568317
Somatic delusion	20.49	12.76	8	20913	558	50583645
Stoma site infection	19.77	12.76	8	20913	613	50583590
Depression	19.46	12.76	126	20795	165297	50418906
Pyrexia	19.44	12.76	86	20835	380117	50204086
Stoma site reaction	19.39	12.76	6	20915	208	50583995
Rheumatoid arthritis	19.15	12.76	34	20887	202516	50381687
Multiple sclerosis	19.01	12.76	32	20889	20461	50563742
Type 2 diabetes mellitus	18.84	12.76	43	20878	34332	50549871
Hypersensitivity	18.69	12.76	38	20883	215123	50369080
Impulsive behaviour	18.69	12.76	10	20911	1448	50582755
Dropped head syndrome	18.59	12.76	5	20916	104	50584099
Fibroma	18.47	12.76	8	20913	727	50583476
Therapeutic product effect variable	18.40	12.76	9	20912	1081	50583122
Asthma	18.04	12.76	79	20842	89258	50494945
Teeth brittle	17.96	12.76	7	20914	486	50583717
Drug intolerance	17.95	12.76	40	20881	219064	50365139
Abnormal behaviour	17.32	12.76	30	20891	19628	50564575
Acute psychosis	17.24	12.76	11	20910	2209	50581994
Acquired haemophilia	16.89	12.76	8	20913	895	50583308
Underdose	16.64	12.76	30	20891	20248	50563955
Urinary tract infection	16.51	12.76	153	20768	223867	50360336
Febrile neutropenia	16.44	12.76	10	20911	97657	50486546
Dermatitis contact	16.32	12.76	19	20902	8627	50575576
Major depression	16.24	12.76	17	20904	6867	50577336
Alopecia	16.06	12.76	50	20871	244997	50339206
Somnolence	15.82	12.76	114	20807	154871	50429332
Pre-existing condition improved	15.81	12.76	17	20904	7080	50577123
Periodic limb movement disorder	15.77	12.76	5	20916	188	50584015
Neutropenia	15.71	12.76	23	20898	147942	50436261
Lower respiratory tract infection	15.68	12.76	10	20911	95191	50489012
Therapy interrupted	15.51	12.76	29	20892	20123	50564080
Thrombocytopenia	15.45	12.76	18	20903	127655	50456548
Resting tremor	15.35	12.76	7	20914	719	50583484
Tension	15.06	12.76	11	20910	2751	50581452
Somnambulism	15.03	12.76	14	20907	4910	50579293
Sleep attacks	14.88	12.76	4	20917	83	50584120
Living in residential institution	14.81	12.76	6	20915	461	50583742
Nightmare	14.76	12.76	25	20896	16061	50568142
Palatal swelling	14.66	12.76	4	20917	88	50584115
Clavicle fracture	14.45	12.76	11	20910	2928	50581275
Eating disorder	14.21	12.76	24	20897	15385	50568818
Anaemia	14.20	12.76	55	20866	252401	50331802
Sudden onset of sleep	14.06	12.76	6	20915	526	50583677
Stoma complication	13.96	12.76	5	20916	274	50583929
Spinal operation	13.95	12.76	15	20906	6245	50577958
Wound	13.81	12.76	14	20907	105780	50478423
Hyperhidrosis	13.67	12.76	73	20848	89353	50494850
Arthropathy	13.61	12.76	28	20893	157878	50426325
Prescribed underdose	13.61	12.76	24	20897	15925	50568278
Cross sensitivity reaction	13.44	12.76	9	20912	1960	50582243
Discomfort	13.41	12.76	15	20906	108365	50475838
Dreamy state	13.19	12.76	3	20918	30	50584173
Complement factor C4 increased	13.09	12.76	4	20917	133	50584070
Respiratory dyskinesia	12.93	12.76	3	20918	33	50584170
Poor quality sleep	12.87	12.76	24	20897	16622	50567581

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypersexuality	298.66	15.65	76	12031	1280	29561140
Hallucination	297.92	15.65	200	11907	44512	29517908
Impulse-control disorder	261.64	15.65	67	12040	1158	29561262
Hallucination, visual	202.40	15.65	106	12001	14909	29547511
Dyskinesia	186.68	15.65	111	11996	19950	29542470
Gambling disorder	185.87	15.65	54	12053	1521	29560899
Dopamine dysregulation syndrome	170.97	15.65	37	12070	292	29562128
On and off phenomenon	154.18	15.65	49	12058	1879	29560541
Freezing phenomenon	147.69	15.65	43	12064	1220	29561200
Sudden onset of sleep	117.59	15.65	28	12079	352	29562068
Muscle rigidity	95.18	15.65	55	12052	9356	29553064
Jealous delusion	83.67	15.65	19	12088	191	29562229
Compulsive shopping	81.43	15.65	21	12086	373	29562047
Bradykinesia	72.47	15.65	33	12074	3414	29559006
Fall	70.01	15.65	194	11913	176984	29385436
Somnolence	68.36	15.65	131	11976	93824	29468596
Delusion	64.67	15.65	46	12061	11170	29551250
Serotonin syndrome	60.28	15.65	53	12054	17459	29544961
Psychotic disorder	59.12	15.65	56	12051	20298	29542122
Hyperkinesia	56.00	15.65	22	12085	1577	29560843
Stoma site discharge	55.95	15.65	19	12088	898	29561522
Confusional state	54.41	15.65	144	11963	127733	29434687
Stereotypy	53.72	15.65	17	12090	642	29561778
Aggression	51.52	15.65	68	12039	35473	29526947
Stoma site erythema	50.21	15.65	16	12091	618	29561802
Balance disorder	47.56	15.65	66	12041	36104	29526316
Dropped head syndrome	47.05	15.65	11	12096	127	29562293
Orthostatic hypotension	47.05	15.65	52	12055	22577	29539843
Therapeutic product effect variable	45.97	15.65	20	12087	1857	29560563
Gambling	43.16	15.65	11	12096	186	29562234
Parkinsonism hyperpyrexia syndrome	40.73	15.65	9	12098	79	29562341
Fibroma	40.26	15.65	11	12096	246	29562174
Abnormal behaviour	37.83	15.65	47	12060	23080	29539340
Device dislocation	36.80	15.65	23	12084	4504	29557916
Abnormal dreams	36.73	15.65	27	12080	6893	29555527
Stoma site pain	36.63	15.65	12	12095	507	29561913
Restless legs syndrome	36.51	15.65	27	12080	6957	29555463
Compulsive sexual behaviour	36.41	15.65	10	12097	228	29562192
Memory impairment	34.37	15.65	57	12050	36413	29526007
Alien limb syndrome	34.01	15.65	5	12102	0	29562420
Compulsions	33.84	15.65	9	12098	181	29562239
Anticholinergic syndrome	33.78	15.65	13	12094	881	29561539
Libido increased	32.76	15.65	12	12095	709	29561711
Gait disturbance	32.56	15.65	84	12023	73265	29489155
Nonspecific reaction	30.60	15.65	13	12094	1138	29561282
Tremor	30.38	15.65	82	12025	73456	29488964
Drug withdrawal syndrome	30.14	15.65	37	12070	17947	29544473
Stress cardiomyopathy	29.33	15.65	14	12093	1610	29560810
Reduced facial expression	29.33	15.65	11	12096	695	29561725
Obsessive-compulsive disorder	29.25	15.65	20	12087	4556	29557864
Thunderclap headache	28.23	15.65	6	12101	43	29562377
Impulsive behaviour	26.95	15.65	14	12093	1929	29560491
Febrile neutropenia	25.84	15.65	7	12100	112233	29450187
Stoma site reaction	25.73	15.65	7	12100	154	29562266
Insomnia	25.40	15.65	87	12020	88674	29473746
Paraphilia	25.15	15.65	6	12101	76	29562344
Tic	24.82	15.65	13	12094	1822	29560598
Paranoia	24.61	15.65	25	12082	9852	29552568
Sleep disorder	24.16	15.65	39	12068	24347	29538073
Torsade de pointes	22.59	15.65	20	12087	6641	29555779
Diarrhoea	22.59	15.65	66	12041	332632	29229788
Cognitive disorder	22.49	15.65	37	12070	23462	29538958
Hypokinesia	22.33	15.65	21	12086	7533	29554887
Progressive supranuclear palsy	22.22	15.65	5	12102	48	29562372
Mydriasis	22.11	15.65	19	12088	6066	29556354
Agitation	21.98	15.65	58	12049	51246	29511174
Product dispensing error	21.74	15.65	18	12089	5462	29556958
Dystonia	21.29	15.65	23	12084	9726	29552694
Suspiciousness	21.27	15.65	7	12100	300	29562120
Speech disorder	21.14	15.65	36	12071	23480	29538940
Hypersomnia	21.12	15.65	24	12083	10730	29551690
Stoma site hypergranulation	21.10	15.65	6	12101	156	29562264
Nocturia	20.53	15.65	21	12086	8341	29554079
Bipolar disorder	20.11	15.65	14	12093	3281	29559139
Irritability	20.03	15.65	34	12073	22118	29540302
Mobility decreased	20.00	15.65	37	12070	25743	29536677
Dysphagia	19.50	15.65	58	12049	54868	29507552
Medical device discomfort	19.29	15.65	4	12103	25	29562395
Middle insomnia	19.08	15.65	17	12090	5691	29556729
Hallucinations, mixed	18.87	15.65	12	12095	2421	29559999
Tension	18.85	15.65	11	12096	1902	29560518
Akinesia	18.45	15.65	11	12096	1979	29560441
Parkinsonian crisis	18.33	15.65	3	12104	3	29562417
Malignant neoplasm progression	18.17	15.65	4	12103	73855	29488565
Salivary gland cancer stage IV	18.11	15.65	4	12103	35	29562385
Reversible cerebral vasoconstriction syndrome	18.10	15.65	6	12101	263	29562157
Hyperphagia	17.39	15.65	9	12098	1231	29561189
Sleep attacks	17.19	15.65	5	12102	141	29562279
Disturbance in attention	16.93	15.65	31	12076	21393	29541027
Obsessive thoughts	16.45	15.65	7	12100	615	29561805
Micturition disorder	16.32	15.65	10	12097	1891	29560529
Device kink	16.28	15.65	6	12101	361	29562059
Neutropenia	16.22	15.65	18	12089	131693	29430727

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hallucination, visual	346.83	13.40	186	26003	27648	64444895
Hallucination	333.75	13.40	259	25930	72529	64400014
Dopamine dysregulation syndrome	313.04	13.40	65	26124	414	64472129
Impulse-control disorder	296.81	13.40	78	26111	1510	64471033
Dyskinesia	294.32	13.40	189	26000	39199	64433344
On and off phenomenon	248.25	13.40	75	26114	2444	64470099
Hypersexuality	226.17	13.40	62	26127	1417	64471126
Compulsive shopping	198.59	13.40	49	26140	728	64471815
Freezing phenomenon	187.23	13.40	54	26135	1492	64471051
Gambling disorder	180.67	13.40	55	26134	1839	64470704
Jealous delusion	137.90	13.40	29	26160	198	64472345
Fall	126.73	13.40	414	25775	416412	64056131
Bradykinesia	120.33	13.40	57	26132	6503	64466040
Hyperkinesia	100.03	13.40	38	26151	2508	64470035
Parkinsonism hyperpyrexia syndrome	92.83	13.40	21	26168	209	64472334
Gait disturbance	87.99	13.40	207	25982	171948	64300595
Restless legs syndrome	87.33	13.40	65	26124	17051	64455492
Delusion	86.57	13.40	66	26123	17948	64454595
Muscle rigidity	86.14	13.40	65	26124	17408	64455135
Stoma site discharge	84.18	13.40	30	26159	1652	64470891
Gambling	82.89	13.40	20	26169	269	64472274
Stoma site erythema	81.05	13.40	27	26162	1212	64471331
Sudden onset of sleep	72.74	13.40	21	26168	582	64471961
Stereotypy	65.82	13.40	21	26168	821	64471722
Drug withdrawal syndrome	63.94	13.40	71	26118	31220	64441323
Tremor	63.84	13.40	167	26022	148063	64324480
Dystonia	59.16	13.40	54	26135	18811	64453732
Somnolence	56.96	13.40	197	25992	203448	64269095
Dropped head syndrome	55.36	13.40	14	26175	231	64472312
Therapeutic product effect variable	52.10	13.40	21	26168	1623	64470920
Psychotic disorder	51.80	13.40	67	26122	34511	64438032
Balance disorder	45.10	13.40	103	26086	83823	64388720
Serotonin syndrome	43.73	13.40	66	26123	39216	64433327
Illusion	42.77	13.40	18	26171	1552	64470991
Binge eating	42.63	13.40	13	26176	437	64472106
Insomnia	42.55	13.40	176	26013	197660	64274883
Impulsive behaviour	42.38	13.40	21	26168	2642	64469901
Orthostatic hypotension	41.71	13.40	71	26118	46667	64425876
Abnormal dreams	41.29	13.40	34	26155	10322	64462221
Withdrawal syndrome	40.76	13.40	49	26140	23443	64449100
Behaviour disorder	39.83	13.40	24	26165	4438	64468105
Confusional state	39.74	13.40	210	25979	260934	64211609
Aggression	39.64	13.40	69	26120	46163	64426380
Memory impairment	39.40	13.40	99	26090	85583	64386960
Full blood count abnormal	38.97	13.40	54	26135	29703	64442840
Psychotic symptom	37.45	13.40	18	26171	2120	64470423
Abnormal behaviour	36.73	13.40	56	26133	33566	64438977
Toxicity to various agents	36.53	13.40	57	26132	363456	64109087
Product dose omission issue	35.58	13.40	165	26024	194582	64277961
Muscle spasms	34.78	13.40	131	26058	140892	64331651
Parkinsonian gait	34.54	13.40	13	26176	836	64471707
Stoma site pain	34.28	13.40	14	26175	1119	64471424
Febrile neutropenia	33.76	13.40	17	26172	187640	64284903
Feeling abnormal	32.85	13.40	124	26065	133478	64339065
Irritability	31.71	13.40	55	26134	36691	64435852
Pyrexia	30.65	13.40	120	26069	558524	63914019
Product dispensing error	30.60	13.40	30	26159	11420	64461123
Parkinsonian crisis	30.11	13.40	5	26184	6	64472537
Oromandibular dystonia	30.10	13.40	12	26177	901	64471642
Infusion related reaction	29.43	13.40	15	26174	164452	64308091
Obsessive-compulsive disorder	28.46	13.40	20	26169	4798	64467745
Progressive supranuclear palsy	28.36	13.40	7	26182	104	64472439
Multiple organ dysfunction syndrome	27.88	13.40	4	26185	101409	64371134
Therapeutic response shortened	27.84	13.40	27	26162	10143	64462400
Nonspecific reaction	26.66	13.40	14	26175	1989	64470554
Eczema eyelids	26.27	13.40	7	26182	143	64472400
Anxiety	26.18	13.40	156	26033	202493	64270050
Somatic delusion	26.03	13.40	10	26179	680	64471863
Prescribed underdose	25.57	13.40	34	26155	17981	64454562
Acute psychosis	25.54	13.40	17	26172	3735	64468808
Hyperphagia	25.24	13.40	14	26175	2217	64470326
Treatment failure	25.22	13.40	8	26181	116808	64355735
Multiple sclerosis relapse	24.93	13.40	53	26136	41082	64431461
Sleep attacks	24.86	13.40	7	26182	177	64472366
Compulsions	24.48	13.40	8	26181	338	64472205
Hallucinations, mixed	24.40	13.40	20	26169	6032	64466511
Dizziness	23.33	13.40	272	25917	429891	64042652
Hepatic enzyme increased	23.02	13.40	12	26177	129931	64342612
Nightmare	22.97	13.40	35	26154	20958	64451585
Neutropenia	22.71	13.40	39	26150	239585	64232958
Hypersensitivity	22.51	13.40	28	26161	196424	64276119
Libido increased	22.38	13.40	12	26177	1778	64470765
Pleurothotonus	22.16	13.40	13	26176	2289	64470254
Disturbance in attention	21.60	13.40	50	26139	41024	64431519
Thrombocytopenia	21.60	13.40	36	26153	223765	64248778
Rheumatoid arthritis	21.48	13.40	21	26168	164273	64308270
Medical device site dryness	21.23	13.40	4	26185	14	64472529
Therapeutic response unexpected	20.99	13.40	30	26159	16971	64455572
Malignant neoplasm progression	20.63	13.40	10	26179	112861	64359682
Interstitial lung disease	20.56	13.40	7	26182	97725	64374818
Nocturia	20.54	13.40	24	26165	11141	64461402
Dementia	20.47	13.40	33	26156	20733	64451810
Movement disorder	20.39	13.40	34	26155	21966	64450577
Anticholinergic syndrome	20.39	13.40	13	26176	2656	64469887
Persecutory delusion	19.46	13.40	15	26174	4143	64468400
Middle insomnia	19.36	13.40	25	26164	12852	64459691
Limbic encephalitis	19.31	13.40	8	26181	663	64471880
Exposure during pregnancy	19.29	13.40	4	26185	77671	64394872
Thunderclap headache	19.17	13.40	6	26183	220	64472323
Resting tremor	19.15	13.40	10	26179	1404	64471139
Obsessive thoughts	19.15	13.40	9	26180	1008	64471535
Fibroma	19.11	13.40	8	26181	681	64471862
Hypersomnia	18.98	13.40	31	26158	19686	64452857
Paranoia	18.95	13.40	28	26161	16324	64456219
Compulsive sexual behaviour	18.58	13.40	6	26183	244	64472299
Type 2 diabetes mellitus	18.53	13.40	42	26147	33978	64438565
Agitation	18.48	13.40	78	26111	88289	64384254
Tension	18.29	13.40	14	26175	3826	64468717
Urinary tract infection	18.10	13.40	158	26031	231438	64241105
Pancytopenia	17.95	13.40	19	26170	143290	64329253
Reduced facial expression	17.92	13.40	11	26178	2102	64470441
Joint swelling	17.83	13.40	38	26151	215344	64257199
Hypertonia	17.70	13.40	17	26172	6308	64466235
Dermatitis contact	17.66	13.40	20	26169	8980	64463563
Depression	17.56	13.40	131	26058	183160	64289383
Posture abnormal	17.52	13.40	13	26176	3393	64469150
Stoma site infection	17.49	13.40	9	26180	1226	64471317
Speech disorder	17.28	13.40	51	26138	48390	64424153
Restlessness	17.27	13.40	45	26144	39740	64432803
Hypokinesia	17.22	13.40	27	26162	16569	64455974
Suspiciousness	16.85	13.40	7	26182	584	64471959
Periodic limb movement disorder	16.81	13.40	5	26184	154	64472389
Hallucination, auditory	16.81	13.40	27	26162	16912	64455631
Gait inability	16.46	13.40	46	26143	42322	64430221
Patient elopement	16.27	13.40	3	26186	9	64472534
Diarrhoea	16.18	13.40	202	25987	722502	63750041
Device occlusion	16.09	13.40	20	26169	9893	64462650
Hyperhidrosis	16.01	13.40	96	26093	124824	64347719
Poor quality sleep	15.87	13.40	28	26161	18923	64453620
Increased appetite	15.72	13.40	20	26169	10126	64462417
Salivary gland cancer stage IV	15.70	13.40	4	26185	68	64472475
Drug intolerance	15.70	13.40	33	26156	187959	64284584
Cerebral atrophy	15.69	13.40	17	26172	7268	64465275
Postural reflex impairment	15.61	13.40	3	26186	12	64472531
Stress cardiomyopathy	15.55	13.40	19	26170	9238	64463305
Dependence	15.24	13.40	10	26179	2145	64470398
Sleep disorder	15.15	13.40	56	26133	59653	64412890
Lower respiratory tract infection	14.97	13.40	10	26179	94604	64377939
Teeth brittle	14.93	13.40	6	26183	460	64472083
Wrong product administered	14.88	13.40	17	26172	7703	64464840
Device dislocation	14.86	13.40	29	26160	21149	64451394
Mental impairment	14.80	13.40	25	26164	16318	64456225
Camptocormia	14.75	13.40	6	26183	475	64472068
Parkinsonism	14.39	13.40	23	26166	14350	64458193
Dysphagia	14.27	13.40	83	26106	106729	64365814
Gastrooesophageal reflux disease	14.11	13.40	69	26120	83074	64389469
Hand deformity	14.09	13.40	4	26185	62767	64409776
Rash	14.01	13.40	119	26070	458430	64014113
Systemic lupus erythematosus	13.99	13.40	7	26182	77605	64394938
Micturition disorder	13.96	13.40	11	26178	3137	64469406
Limb injury	13.91	13.40	30	26159	23475	64449068
Therapeutic product effect delayed	13.68	13.40	10	26179	2549	64469994
Tic	13.48	13.40	10	26179	2609	64469934

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N04BC04	NERVOUS SYSTEM ANTI-PARKINSON DRUGS DOPAMINERGIC AGENTS Dopamine agonists
FDA MoA	N0000000117	Dopamine Agonists
MeSH PA	D018726	Anti-Dyskinesia Agents
MeSH PA	D000978	Antiparkinson Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D015259	Dopamine Agents
MeSH PA	D018491	Dopamine Agonists
MeSH PA	D018377	Neurotransmitter Agents
CHEBI has role	CHEBI:35470	central nervous system agents
CHEBI has role	CHEBI:48407	antiparkinson agent
CHEBI has role	CHEBI:51065	Dopamine receptor agonist
CHEBI has role	CHEBI:66956	antidyskinetic agent
FDA EPC	N0000175768	Nonergot Dopamine Agonist

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Restless legs	indication	32914008	DOID:0050425
Parkinson's disease	indication	49049000	DOID:14330
Hallucinations	contraindication	7011001
Dyskinesia	contraindication	9748009
Orthostatic hypotension	contraindication	28651003
Low blood pressure	contraindication	45007003
Bradycardia	contraindication	48867003
Acute nephropathy	contraindication	58574008
Hepatic failure	contraindication	59927004
Psychotic disorder	contraindication	69322001
Syncope	contraindication	271594007
Drowsy	contraindication	271782001
Central nervous system depression	contraindication	418072004
Smokes tobacco daily	contraindication	449868002

🐶 Veterinary Drug Use

None

🐶 Veterinary products

Product	Applicant	Ingredients
CLEVOR	Orion Corp.	1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.82	acidic
pKa2	9.18	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN	AGONIST	Ki	8.14	IUPHAR	IUPHAR
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN		Ki	5.73	PDSP
5-hydroxytryptamine receptor 1A	GPCR	P08908	5HT1A_HUMAN		Ki	6.54	WOMBAT-PK
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN		EC50	6.85	CHEMBL
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	5.42	PDSP
5-hydroxytryptamine receptor 7	GPCR	P34969	5HT7R_HUMAN		Ki	5.82	PDSP
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN		Ki	6.12	WOMBAT-PK
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN	AGONIST	Ki	7.43	WOMBAT-PK
D(1B) dopamine receptor	GPCR	P21918	DRD5_HUMAN		Ki	4.38	CHEMBL
5-hydroxytryptamine receptor 1D	GPCR	P28221	5HT1D_HUMAN		Ki	5.86	PDSP
Alpha-2C adrenergic receptor	GPCR	P18825	ADA2C_HUMAN		Ki	5.92	PDSP
D(4) dopamine receptor	GPCR	P21917	DRD4_HUMAN	AGONIST	Ki	6.07	WOMBAT-PK
D(1A) dopamine receptor	GPCR	P21728	DRD1_HUMAN		Ki	4.49	CHEMBL
D(2) dopamine receptor	GPCR		DRD2_RAT		Ki	5.57	CHEMBL
D(2) dopamine receptor	GPCR		DRD2_BOVIN		IC50	5.17	CHEMBL
D(3) dopamine receptor	GPCR		DRD3_RAT		Ki	7.53	CHEMBL

External reference:

ID	Source
4024081	VUID
N0000022086	NUI
D00784	KEGG_DRUG
91374-20-8	SECONDARY_CAS_RN
4021058	VANDF
4024081	VANDF
C0244821	UMLSCUI
CHEBI:8888	CHEBI
CHEMBL589	ChEMBL_ID
CHEMBL1200411	ChEMBL_ID
DB00268	DRUGBANK_ID
C046649	MESH_SUPPLEMENTAL_RECORD_UI
5095	PUBCHEM_CID
7295	IUPHAR_LIGAND_ID
6436	INN_ID
030PYR8953	UNII
152951	RXNORM
11369	MMSL
136707	MMSL
5434	MMSL
d04215	MMSL
006273	NDDF
006274	NDDF
108473005	SNOMEDCT_US
108474004	SNOMEDCT_US
372499000	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Ropinirole	HUMAN PRESCRIPTION DRUG LABEL	1	0228-3640	TABLET, FILM COATED, EXTENDED RELEASE	6 mg	ORAL	ANDA	18 sections
Ropinirole	HUMAN PRESCRIPTION DRUG LABEL	1	0228-3658	TABLET, FILM COATED, EXTENDED RELEASE	2 mg	ORAL	ANDA	18 sections
Ropinirole	HUMAN PRESCRIPTION DRUG LABEL	1	0228-3659	TABLET, FILM COATED, EXTENDED RELEASE	4 mg	ORAL	ANDA	18 sections
Ropinirole	HUMAN PRESCRIPTION DRUG LABEL	1	0228-3660	TABLET, FILM COATED, EXTENDED RELEASE	8 mg	ORAL	ANDA	18 sections
Ropinirole	HUMAN PRESCRIPTION DRUG LABEL	1	0228-3661	TABLET, FILM COATED, EXTENDED RELEASE	12 mg	ORAL	ANDA	18 sections
Ropinirole	HUMAN PRESCRIPTION DRUG LABEL	1	0378-5501	TABLET	1 mg	ORAL	ANDA	28 sections
Ropinirole	HUMAN PRESCRIPTION DRUG LABEL	1	0378-5502	TABLET	2 mg	ORAL	ANDA	28 sections
Ropinirole	HUMAN PRESCRIPTION DRUG LABEL	1	0378-5503	TABLET	3 mg	ORAL	ANDA	28 sections
Ropinirole	HUMAN PRESCRIPTION DRUG LABEL	1	0378-5504	TABLET	4 mg	ORAL	ANDA	28 sections
Ropinirole	HUMAN PRESCRIPTION DRUG LABEL	1	0378-5505	TABLET	5 mg	ORAL	ANDA	28 sections
Ropinirole	HUMAN PRESCRIPTION DRUG LABEL	1	0378-5525	TABLET	0.25 mg	ORAL	ANDA	28 sections
Ropinirole	HUMAN PRESCRIPTION DRUG LABEL	1	0378-5550	TABLET	0.50 mg	ORAL	ANDA	28 sections
ROPINIROLE HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8188	TABLET, FILM COATED	0.25 mg	ORAL	ANDA	26 sections
ROPINIROLE HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8189	TABLET, FILM COATED	0.50 mg	ORAL	ANDA	26 sections
ROPINIROLE HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8190	TABLET, FILM COATED	1 mg	ORAL	ANDA	26 sections
ROPINIROLE HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8191	TABLET, FILM COATED	2 mg	ORAL	ANDA	26 sections
ropinirole	HUMAN PRESCRIPTION DRUG LABEL	1	0781-5780	TABLET, FILM COATED, EXTENDED RELEASE	2 mg	ORAL	ANDA	24 sections
ropinirole	HUMAN PRESCRIPTION DRUG LABEL	1	0781-5782	TABLET, FILM COATED, EXTENDED RELEASE	4 mg	ORAL	ANDA	24 sections
ropinirole	HUMAN PRESCRIPTION DRUG LABEL	1	0781-5784	TABLET, FILM COATED, EXTENDED RELEASE	6 mg	ORAL	ANDA	24 sections
ropinirole	HUMAN PRESCRIPTION DRUG LABEL	1	0781-5786	TABLET, FILM COATED, EXTENDED RELEASE	8 mg	ORAL	ANDA	24 sections
ropinirole	HUMAN PRESCRIPTION DRUG LABEL	1	0781-5788	TABLET, FILM COATED, EXTENDED RELEASE	12 mg	ORAL	ANDA	24 sections
ROPINIROLE HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6373	TABLET, FILM COATED	0.25 mg	ORAL	ANDA	27 sections
ROPINIROLE HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6374	TABLET, FILM COATED	1 mg	ORAL	ANDA	27 sections
Ropinirole	HUMAN PRESCRIPTION DRUG LABEL	1	10135-673	TABLET, FILM COATED	0.25 mg	ORAL	ANDA	28 sections
Ropinirole	HUMAN PRESCRIPTION DRUG LABEL	1	10135-674	TABLET, FILM COATED	0.50 mg	ORAL	ANDA	28 sections
Ropinirole	HUMAN PRESCRIPTION DRUG LABEL	1	10135-675	TABLET, FILM COATED	1 mg	ORAL	ANDA	28 sections
Ropinirole	HUMAN PRESCRIPTION DRUG LABEL	1	10135-676	TABLET, FILM COATED	2 mg	ORAL	ANDA	28 sections
Ropinirole	HUMAN PRESCRIPTION DRUG LABEL	1	10135-677	TABLET, FILM COATED	3 mg	ORAL	ANDA	28 sections
Ropinirole	HUMAN PRESCRIPTION DRUG LABEL	1	10135-678	TABLET, FILM COATED	4 mg	ORAL	ANDA	28 sections
Ropinirole	HUMAN PRESCRIPTION DRUG LABEL	1	10135-679	TABLET, FILM COATED	5 mg	ORAL	ANDA	28 sections