ropinirole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2402 91374-21-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ropinirol
  • requip
  • ropinirole
  • ropinirole hydrochloride
  • ropinirole HCl
Ropinirole is a non-ergoline dopamine agonist. The precise mechanism of action of ropinirole as a treatment for Parkinson’s disease is unknown, although it is thought to be related to its ability to stimulate dopamine D2 receptors within the caudate-putamen in the brain.
  • Molecular weight: 260.38
  • Formula: C16H24N2O
  • CLOGP: 2.80
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 32.34
  • ALOGS: -2.87
  • ROTB: 7

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
6 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 133 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 5 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.32 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 55 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 7.70 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 30 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.60 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 6 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Sept. 19, 1997 FDA GLAXOSMITHKLINE LLC
Sept. 20, 2019 PMDA Hisamitsu Pharmaceutical Co., Inc.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Dyskinesia 209.17 12.76 135 20786 27726 50556477
Compulsive shopping 191.39 12.76 47 20874 671 50583532
On and off phenomenon 168.72 12.76 49 20872 1363 50582840
Hallucination 165.14 12.76 144 20777 46513 50537690
Hallucination, visual 159.16 12.76 94 20827 16488 50567715
Dopamine dysregulation syndrome 150.75 12.76 30 20891 146 50584057
Restless legs syndrome 109.44 12.76 73 20848 15824 50568379
Impulse-control disorder 101.54 12.76 28 20893 642 50583561
Bradykinesia 80.18 12.76 37 20884 3906 50580297
Stoma site discharge 75.90 12.76 26 20895 1249 50582954
Fall 75.79 12.76 306 20615 334626 50249577
Freezing phenomenon 73.55 12.76 24 20897 991 50583212
Gait disturbance 72.02 12.76 178 20743 149827 50434376
Stoma site erythema 68.35 12.76 22 20899 869 50583334
Gambling 65.70 12.76 16 20905 220 50583983
Tremor 65.67 12.76 146 20775 114757 50469446
Gambling disorder 58.26 12.76 21 20900 1173 50583030
Hyperkinesia 57.84 12.76 22 20899 1430 50582773
Jealous delusion 54.07 12.76 10 20911 30 50584173
Parkinsonism hyperpyrexia syndrome 52.42 12.76 12 20909 124 50584079
Full blood count abnormal 48.60 12.76 54 20867 23334 50560869
Infusion related reaction 42.71 12.76 9 20912 169548 50414655
Delusion 42.22 12.76 35 20886 10534 50573669
Memory impairment 42.15 12.76 98 20823 79262 50504941
Illusion 39.90 12.76 15 20906 944 50583259
Insomnia 39.59 12.76 160 20761 174705 50409498
Product dose omission issue 39.10 12.76 165 20756 183673 50400530
Parkinsonian gait 38.40 12.76 12 20909 430 50583773
Hypersexuality 38.09 12.76 12 20909 442 50583761
Binge eating 35.42 12.76 11 20910 386 50583817
Stoma site pain 35.02 12.76 13 20908 790 50583413
Treatment failure 33.26 12.76 8 20913 137629 50446574
Psychotic symptom 33.13 12.76 14 20907 1198 50583005
Balance disorder 31.97 12.76 82 20839 70508 50513695
Joint swelling 31.47 12.76 33 20888 245253 50338950
Drug withdrawal syndrome 31.45 12.76 45 20876 25036 50559167
Exposure during pregnancy 31.35 12.76 6 20915 121009 50463194
Muscle spasms 30.92 12.76 118 20803 125435 50458768
Withdrawal syndrome 30.49 12.76 37 20884 17553 50566650
Oromandibular dystonia 30.25 12.76 10 20911 430 50583773
Muscle rigidity 30.12 12.76 28 20893 9801 50574402
Dystonia 29.12 12.76 30 20891 11896 50572307
Eczema eyelids 27.64 12.76 7 20914 114 50584089
Limbic encephalitis 27.45 12.76 8 20913 225 50583978
Glossodynia 27.37 12.76 7 20914 115562 50468641
Multiple sclerosis relapse 27.26 12.76 57 20864 42907 50541296
Systemic lupus erythematosus 27.25 12.76 12 20909 140610 50443593
Feeling abnormal 26.93 12.76 113 20808 125379 50458824
Mental impairment 25.35 12.76 28 20893 12016 50572187
Hyperglycaemia 25.11 12.76 50 20871 36355 50547848
Toxicity to various agents 24.64 12.76 31 20890 212468 50371735
Anxiety 24.54 12.76 141 20780 177465 50406738
Therapeutic response shortened 24.50 12.76 22 20899 7367 50576836
Gastrooesophageal reflux disease 24.13 12.76 78 20843 76350 50507853
Dizziness 23.82 12.76 233 20688 346136 50238067
Abnormal dreams 23.64 12.76 24 20897 9353 50574850
Stereotypy 23.56 12.76 8 20913 374 50583829
Hepatic enzyme increased 23.23 12.76 14 20907 137366 50446837
Posture abnormal 23.12 12.76 13 20908 2076 50582127
Pleurothotonus 22.74 12.76 11 20910 1290 50582913
Behaviour disorder 21.54 12.76 13 20908 2367 50581836
Therapeutic response unexpected 20.61 12.76 29 20892 15886 50568317
Somatic delusion 20.49 12.76 8 20913 558 50583645
Stoma site infection 19.77 12.76 8 20913 613 50583590
Depression 19.46 12.76 126 20795 165297 50418906
Pyrexia 19.44 12.76 86 20835 380117 50204086
Stoma site reaction 19.39 12.76 6 20915 208 50583995
Rheumatoid arthritis 19.15 12.76 34 20887 202516 50381687
Multiple sclerosis 19.01 12.76 32 20889 20461 50563742
Type 2 diabetes mellitus 18.84 12.76 43 20878 34332 50549871
Hypersensitivity 18.69 12.76 38 20883 215123 50369080
Impulsive behaviour 18.69 12.76 10 20911 1448 50582755
Dropped head syndrome 18.59 12.76 5 20916 104 50584099
Fibroma 18.47 12.76 8 20913 727 50583476
Therapeutic product effect variable 18.40 12.76 9 20912 1081 50583122
Asthma 18.04 12.76 79 20842 89258 50494945
Teeth brittle 17.96 12.76 7 20914 486 50583717
Drug intolerance 17.95 12.76 40 20881 219064 50365139
Abnormal behaviour 17.32 12.76 30 20891 19628 50564575
Acute psychosis 17.24 12.76 11 20910 2209 50581994
Acquired haemophilia 16.89 12.76 8 20913 895 50583308
Underdose 16.64 12.76 30 20891 20248 50563955
Urinary tract infection 16.51 12.76 153 20768 223867 50360336
Febrile neutropenia 16.44 12.76 10 20911 97657 50486546
Dermatitis contact 16.32 12.76 19 20902 8627 50575576
Major depression 16.24 12.76 17 20904 6867 50577336
Alopecia 16.06 12.76 50 20871 244997 50339206
Somnolence 15.82 12.76 114 20807 154871 50429332
Pre-existing condition improved 15.81 12.76 17 20904 7080 50577123
Periodic limb movement disorder 15.77 12.76 5 20916 188 50584015
Neutropenia 15.71 12.76 23 20898 147942 50436261
Lower respiratory tract infection 15.68 12.76 10 20911 95191 50489012
Therapy interrupted 15.51 12.76 29 20892 20123 50564080
Thrombocytopenia 15.45 12.76 18 20903 127655 50456548
Resting tremor 15.35 12.76 7 20914 719 50583484
Tension 15.06 12.76 11 20910 2751 50581452
Somnambulism 15.03 12.76 14 20907 4910 50579293
Sleep attacks 14.88 12.76 4 20917 83 50584120
Living in residential institution 14.81 12.76 6 20915 461 50583742
Nightmare 14.76 12.76 25 20896 16061 50568142
Palatal swelling 14.66 12.76 4 20917 88 50584115
Clavicle fracture 14.45 12.76 11 20910 2928 50581275
Eating disorder 14.21 12.76 24 20897 15385 50568818
Anaemia 14.20 12.76 55 20866 252401 50331802
Sudden onset of sleep 14.06 12.76 6 20915 526 50583677
Stoma complication 13.96 12.76 5 20916 274 50583929
Spinal operation 13.95 12.76 15 20906 6245 50577958
Wound 13.81 12.76 14 20907 105780 50478423
Hyperhidrosis 13.67 12.76 73 20848 89353 50494850
Arthropathy 13.61 12.76 28 20893 157878 50426325
Prescribed underdose 13.61 12.76 24 20897 15925 50568278
Cross sensitivity reaction 13.44 12.76 9 20912 1960 50582243
Discomfort 13.41 12.76 15 20906 108365 50475838
Dreamy state 13.19 12.76 3 20918 30 50584173
Complement factor C4 increased 13.09 12.76 4 20917 133 50584070
Respiratory dyskinesia 12.93 12.76 3 20918 33 50584170
Poor quality sleep 12.87 12.76 24 20897 16622 50567581

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypersexuality 298.66 15.65 76 12031 1280 29561140
Hallucination 297.92 15.65 200 11907 44512 29517908
Impulse-control disorder 261.64 15.65 67 12040 1158 29561262
Hallucination, visual 202.40 15.65 106 12001 14909 29547511
Dyskinesia 186.68 15.65 111 11996 19950 29542470
Gambling disorder 185.87 15.65 54 12053 1521 29560899
Dopamine dysregulation syndrome 170.97 15.65 37 12070 292 29562128
On and off phenomenon 154.18 15.65 49 12058 1879 29560541
Freezing phenomenon 147.69 15.65 43 12064 1220 29561200
Sudden onset of sleep 117.59 15.65 28 12079 352 29562068
Muscle rigidity 95.18 15.65 55 12052 9356 29553064
Jealous delusion 83.67 15.65 19 12088 191 29562229
Compulsive shopping 81.43 15.65 21 12086 373 29562047
Bradykinesia 72.47 15.65 33 12074 3414 29559006
Fall 70.01 15.65 194 11913 176984 29385436
Somnolence 68.36 15.65 131 11976 93824 29468596
Delusion 64.67 15.65 46 12061 11170 29551250
Serotonin syndrome 60.28 15.65 53 12054 17459 29544961
Psychotic disorder 59.12 15.65 56 12051 20298 29542122
Hyperkinesia 56.00 15.65 22 12085 1577 29560843
Stoma site discharge 55.95 15.65 19 12088 898 29561522
Confusional state 54.41 15.65 144 11963 127733 29434687
Stereotypy 53.72 15.65 17 12090 642 29561778
Aggression 51.52 15.65 68 12039 35473 29526947
Stoma site erythema 50.21 15.65 16 12091 618 29561802
Balance disorder 47.56 15.65 66 12041 36104 29526316
Dropped head syndrome 47.05 15.65 11 12096 127 29562293
Orthostatic hypotension 47.05 15.65 52 12055 22577 29539843
Therapeutic product effect variable 45.97 15.65 20 12087 1857 29560563
Gambling 43.16 15.65 11 12096 186 29562234
Parkinsonism hyperpyrexia syndrome 40.73 15.65 9 12098 79 29562341
Fibroma 40.26 15.65 11 12096 246 29562174
Abnormal behaviour 37.83 15.65 47 12060 23080 29539340
Device dislocation 36.80 15.65 23 12084 4504 29557916
Abnormal dreams 36.73 15.65 27 12080 6893 29555527
Stoma site pain 36.63 15.65 12 12095 507 29561913
Restless legs syndrome 36.51 15.65 27 12080 6957 29555463
Compulsive sexual behaviour 36.41 15.65 10 12097 228 29562192
Memory impairment 34.37 15.65 57 12050 36413 29526007
Alien limb syndrome 34.01 15.65 5 12102 0 29562420
Compulsions 33.84 15.65 9 12098 181 29562239
Anticholinergic syndrome 33.78 15.65 13 12094 881 29561539
Libido increased 32.76 15.65 12 12095 709 29561711
Gait disturbance 32.56 15.65 84 12023 73265 29489155
Nonspecific reaction 30.60 15.65 13 12094 1138 29561282
Tremor 30.38 15.65 82 12025 73456 29488964
Drug withdrawal syndrome 30.14 15.65 37 12070 17947 29544473
Stress cardiomyopathy 29.33 15.65 14 12093 1610 29560810
Reduced facial expression 29.33 15.65 11 12096 695 29561725
Obsessive-compulsive disorder 29.25 15.65 20 12087 4556 29557864
Thunderclap headache 28.23 15.65 6 12101 43 29562377
Impulsive behaviour 26.95 15.65 14 12093 1929 29560491
Febrile neutropenia 25.84 15.65 7 12100 112233 29450187
Stoma site reaction 25.73 15.65 7 12100 154 29562266
Insomnia 25.40 15.65 87 12020 88674 29473746
Paraphilia 25.15 15.65 6 12101 76 29562344
Tic 24.82 15.65 13 12094 1822 29560598
Paranoia 24.61 15.65 25 12082 9852 29552568
Sleep disorder 24.16 15.65 39 12068 24347 29538073
Torsade de pointes 22.59 15.65 20 12087 6641 29555779
Diarrhoea 22.59 15.65 66 12041 332632 29229788
Cognitive disorder 22.49 15.65 37 12070 23462 29538958
Hypokinesia 22.33 15.65 21 12086 7533 29554887
Progressive supranuclear palsy 22.22 15.65 5 12102 48 29562372
Mydriasis 22.11 15.65 19 12088 6066 29556354
Agitation 21.98 15.65 58 12049 51246 29511174
Product dispensing error 21.74 15.65 18 12089 5462 29556958
Dystonia 21.29 15.65 23 12084 9726 29552694
Suspiciousness 21.27 15.65 7 12100 300 29562120
Speech disorder 21.14 15.65 36 12071 23480 29538940
Hypersomnia 21.12 15.65 24 12083 10730 29551690
Stoma site hypergranulation 21.10 15.65 6 12101 156 29562264
Nocturia 20.53 15.65 21 12086 8341 29554079
Bipolar disorder 20.11 15.65 14 12093 3281 29559139
Irritability 20.03 15.65 34 12073 22118 29540302
Mobility decreased 20.00 15.65 37 12070 25743 29536677
Dysphagia 19.50 15.65 58 12049 54868 29507552
Medical device discomfort 19.29 15.65 4 12103 25 29562395
Middle insomnia 19.08 15.65 17 12090 5691 29556729
Hallucinations, mixed 18.87 15.65 12 12095 2421 29559999
Tension 18.85 15.65 11 12096 1902 29560518
Akinesia 18.45 15.65 11 12096 1979 29560441
Parkinsonian crisis 18.33 15.65 3 12104 3 29562417
Malignant neoplasm progression 18.17 15.65 4 12103 73855 29488565
Salivary gland cancer stage IV 18.11 15.65 4 12103 35 29562385
Reversible cerebral vasoconstriction syndrome 18.10 15.65 6 12101 263 29562157
Hyperphagia 17.39 15.65 9 12098 1231 29561189
Sleep attacks 17.19 15.65 5 12102 141 29562279
Disturbance in attention 16.93 15.65 31 12076 21393 29541027
Obsessive thoughts 16.45 15.65 7 12100 615 29561805
Micturition disorder 16.32 15.65 10 12097 1891 29560529
Device kink 16.28 15.65 6 12101 361 29562059
Neutropenia 16.22 15.65 18 12089 131693 29430727

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hallucination, visual 346.83 13.40 186 26003 27648 64444895
Hallucination 333.75 13.40 259 25930 72529 64400014
Dopamine dysregulation syndrome 313.04 13.40 65 26124 414 64472129
Impulse-control disorder 296.81 13.40 78 26111 1510 64471033
Dyskinesia 294.32 13.40 189 26000 39199 64433344
On and off phenomenon 248.25 13.40 75 26114 2444 64470099
Hypersexuality 226.17 13.40 62 26127 1417 64471126
Compulsive shopping 198.59 13.40 49 26140 728 64471815
Freezing phenomenon 187.23 13.40 54 26135 1492 64471051
Gambling disorder 180.67 13.40 55 26134 1839 64470704
Jealous delusion 137.90 13.40 29 26160 198 64472345
Fall 126.73 13.40 414 25775 416412 64056131
Bradykinesia 120.33 13.40 57 26132 6503 64466040
Hyperkinesia 100.03 13.40 38 26151 2508 64470035
Parkinsonism hyperpyrexia syndrome 92.83 13.40 21 26168 209 64472334
Gait disturbance 87.99 13.40 207 25982 171948 64300595
Restless legs syndrome 87.33 13.40 65 26124 17051 64455492
Delusion 86.57 13.40 66 26123 17948 64454595
Muscle rigidity 86.14 13.40 65 26124 17408 64455135
Stoma site discharge 84.18 13.40 30 26159 1652 64470891
Gambling 82.89 13.40 20 26169 269 64472274
Stoma site erythema 81.05 13.40 27 26162 1212 64471331
Sudden onset of sleep 72.74 13.40 21 26168 582 64471961
Stereotypy 65.82 13.40 21 26168 821 64471722
Drug withdrawal syndrome 63.94 13.40 71 26118 31220 64441323
Tremor 63.84 13.40 167 26022 148063 64324480
Dystonia 59.16 13.40 54 26135 18811 64453732
Somnolence 56.96 13.40 197 25992 203448 64269095
Dropped head syndrome 55.36 13.40 14 26175 231 64472312
Therapeutic product effect variable 52.10 13.40 21 26168 1623 64470920
Psychotic disorder 51.80 13.40 67 26122 34511 64438032
Balance disorder 45.10 13.40 103 26086 83823 64388720
Serotonin syndrome 43.73 13.40 66 26123 39216 64433327
Illusion 42.77 13.40 18 26171 1552 64470991
Binge eating 42.63 13.40 13 26176 437 64472106
Insomnia 42.55 13.40 176 26013 197660 64274883
Impulsive behaviour 42.38 13.40 21 26168 2642 64469901
Orthostatic hypotension 41.71 13.40 71 26118 46667 64425876
Abnormal dreams 41.29 13.40 34 26155 10322 64462221
Withdrawal syndrome 40.76 13.40 49 26140 23443 64449100
Behaviour disorder 39.83 13.40 24 26165 4438 64468105
Confusional state 39.74 13.40 210 25979 260934 64211609
Aggression 39.64 13.40 69 26120 46163 64426380
Memory impairment 39.40 13.40 99 26090 85583 64386960
Full blood count abnormal 38.97 13.40 54 26135 29703 64442840
Psychotic symptom 37.45 13.40 18 26171 2120 64470423
Abnormal behaviour 36.73 13.40 56 26133 33566 64438977
Toxicity to various agents 36.53 13.40 57 26132 363456 64109087
Product dose omission issue 35.58 13.40 165 26024 194582 64277961
Muscle spasms 34.78 13.40 131 26058 140892 64331651
Parkinsonian gait 34.54 13.40 13 26176 836 64471707
Stoma site pain 34.28 13.40 14 26175 1119 64471424
Febrile neutropenia 33.76 13.40 17 26172 187640 64284903
Feeling abnormal 32.85 13.40 124 26065 133478 64339065
Irritability 31.71 13.40 55 26134 36691 64435852
Pyrexia 30.65 13.40 120 26069 558524 63914019
Product dispensing error 30.60 13.40 30 26159 11420 64461123
Parkinsonian crisis 30.11 13.40 5 26184 6 64472537
Oromandibular dystonia 30.10 13.40 12 26177 901 64471642
Infusion related reaction 29.43 13.40 15 26174 164452 64308091
Obsessive-compulsive disorder 28.46 13.40 20 26169 4798 64467745
Progressive supranuclear palsy 28.36 13.40 7 26182 104 64472439
Multiple organ dysfunction syndrome 27.88 13.40 4 26185 101409 64371134
Therapeutic response shortened 27.84 13.40 27 26162 10143 64462400
Nonspecific reaction 26.66 13.40 14 26175 1989 64470554
Eczema eyelids 26.27 13.40 7 26182 143 64472400
Anxiety 26.18 13.40 156 26033 202493 64270050
Somatic delusion 26.03 13.40 10 26179 680 64471863
Prescribed underdose 25.57 13.40 34 26155 17981 64454562
Acute psychosis 25.54 13.40 17 26172 3735 64468808
Hyperphagia 25.24 13.40 14 26175 2217 64470326
Treatment failure 25.22 13.40 8 26181 116808 64355735
Multiple sclerosis relapse 24.93 13.40 53 26136 41082 64431461
Sleep attacks 24.86 13.40 7 26182 177 64472366
Compulsions 24.48 13.40 8 26181 338 64472205
Hallucinations, mixed 24.40 13.40 20 26169 6032 64466511
Dizziness 23.33 13.40 272 25917 429891 64042652
Hepatic enzyme increased 23.02 13.40 12 26177 129931 64342612
Nightmare 22.97 13.40 35 26154 20958 64451585
Neutropenia 22.71 13.40 39 26150 239585 64232958
Hypersensitivity 22.51 13.40 28 26161 196424 64276119
Libido increased 22.38 13.40 12 26177 1778 64470765
Pleurothotonus 22.16 13.40 13 26176 2289 64470254
Disturbance in attention 21.60 13.40 50 26139 41024 64431519
Thrombocytopenia 21.60 13.40 36 26153 223765 64248778
Rheumatoid arthritis 21.48 13.40 21 26168 164273 64308270
Medical device site dryness 21.23 13.40 4 26185 14 64472529
Therapeutic response unexpected 20.99 13.40 30 26159 16971 64455572
Malignant neoplasm progression 20.63 13.40 10 26179 112861 64359682
Interstitial lung disease 20.56 13.40 7 26182 97725 64374818
Nocturia 20.54 13.40 24 26165 11141 64461402
Dementia 20.47 13.40 33 26156 20733 64451810
Movement disorder 20.39 13.40 34 26155 21966 64450577
Anticholinergic syndrome 20.39 13.40 13 26176 2656 64469887
Persecutory delusion 19.46 13.40 15 26174 4143 64468400
Middle insomnia 19.36 13.40 25 26164 12852 64459691
Limbic encephalitis 19.31 13.40 8 26181 663 64471880
Exposure during pregnancy 19.29 13.40 4 26185 77671 64394872
Thunderclap headache 19.17 13.40 6 26183 220 64472323
Resting tremor 19.15 13.40 10 26179 1404 64471139
Obsessive thoughts 19.15 13.40 9 26180 1008 64471535
Fibroma 19.11 13.40 8 26181 681 64471862
Hypersomnia 18.98 13.40 31 26158 19686 64452857
Paranoia 18.95 13.40 28 26161 16324 64456219
Compulsive sexual behaviour 18.58 13.40 6 26183 244 64472299
Type 2 diabetes mellitus 18.53 13.40 42 26147 33978 64438565
Agitation 18.48 13.40 78 26111 88289 64384254
Tension 18.29 13.40 14 26175 3826 64468717
Urinary tract infection 18.10 13.40 158 26031 231438 64241105
Pancytopenia 17.95 13.40 19 26170 143290 64329253
Reduced facial expression 17.92 13.40 11 26178 2102 64470441
Joint swelling 17.83 13.40 38 26151 215344 64257199
Hypertonia 17.70 13.40 17 26172 6308 64466235
Dermatitis contact 17.66 13.40 20 26169 8980 64463563
Depression 17.56 13.40 131 26058 183160 64289383
Posture abnormal 17.52 13.40 13 26176 3393 64469150
Stoma site infection 17.49 13.40 9 26180 1226 64471317
Speech disorder 17.28 13.40 51 26138 48390 64424153
Restlessness 17.27 13.40 45 26144 39740 64432803
Hypokinesia 17.22 13.40 27 26162 16569 64455974
Suspiciousness 16.85 13.40 7 26182 584 64471959
Periodic limb movement disorder 16.81 13.40 5 26184 154 64472389
Hallucination, auditory 16.81 13.40 27 26162 16912 64455631
Gait inability 16.46 13.40 46 26143 42322 64430221
Patient elopement 16.27 13.40 3 26186 9 64472534
Diarrhoea 16.18 13.40 202 25987 722502 63750041
Device occlusion 16.09 13.40 20 26169 9893 64462650
Hyperhidrosis 16.01 13.40 96 26093 124824 64347719
Poor quality sleep 15.87 13.40 28 26161 18923 64453620
Increased appetite 15.72 13.40 20 26169 10126 64462417
Salivary gland cancer stage IV 15.70 13.40 4 26185 68 64472475
Drug intolerance 15.70 13.40 33 26156 187959 64284584
Cerebral atrophy 15.69 13.40 17 26172 7268 64465275
Postural reflex impairment 15.61 13.40 3 26186 12 64472531
Stress cardiomyopathy 15.55 13.40 19 26170 9238 64463305
Dependence 15.24 13.40 10 26179 2145 64470398
Sleep disorder 15.15 13.40 56 26133 59653 64412890
Lower respiratory tract infection 14.97 13.40 10 26179 94604 64377939
Teeth brittle 14.93 13.40 6 26183 460 64472083
Wrong product administered 14.88 13.40 17 26172 7703 64464840
Device dislocation 14.86 13.40 29 26160 21149 64451394
Mental impairment 14.80 13.40 25 26164 16318 64456225
Camptocormia 14.75 13.40 6 26183 475 64472068
Parkinsonism 14.39 13.40 23 26166 14350 64458193
Dysphagia 14.27 13.40 83 26106 106729 64365814
Gastrooesophageal reflux disease 14.11 13.40 69 26120 83074 64389469
Hand deformity 14.09 13.40 4 26185 62767 64409776
Rash 14.01 13.40 119 26070 458430 64014113
Systemic lupus erythematosus 13.99 13.40 7 26182 77605 64394938
Micturition disorder 13.96 13.40 11 26178 3137 64469406
Limb injury 13.91 13.40 30 26159 23475 64449068
Therapeutic product effect delayed 13.68 13.40 10 26179 2549 64469994
Tic 13.48 13.40 10 26179 2609 64469934

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N04BC04 NERVOUS SYSTEM
ANTI-PARKINSON DRUGS
DOPAMINERGIC AGENTS
Dopamine agonists
FDA MoA N0000000117 Dopamine Agonists
MeSH PA D018726 Anti-Dyskinesia Agents
MeSH PA D000978 Antiparkinson Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D015259 Dopamine Agents
MeSH PA D018491 Dopamine Agonists
MeSH PA D018377 Neurotransmitter Agents
CHEBI has role CHEBI:35470 central nervous system agents
CHEBI has role CHEBI:48407 antiparkinson agent
CHEBI has role CHEBI:51065 Dopamine receptor agonist
CHEBI has role CHEBI:66956 antidyskinetic agent
FDA EPC N0000175768 Nonergot Dopamine Agonist

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Restless legs indication 32914008 DOID:0050425
Parkinson's disease indication 49049000 DOID:14330
Hallucinations contraindication 7011001
Dyskinesia contraindication 9748009
Orthostatic hypotension contraindication 28651003
Low blood pressure contraindication 45007003
Bradycardia contraindication 48867003
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Psychotic disorder contraindication 69322001
Syncope contraindication 271594007
Drowsy contraindication 271782001
Central nervous system depression contraindication 418072004
Smokes tobacco daily contraindication 449868002




🐶 Veterinary Drug Use

SpeciesUseRelation
Dogs Induction of vomiting indication

🐶 Veterinary products

ProductApplicantIngredients
CLEVOR Orion Corp. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.82 acidic
pKa2 9.18 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(2) dopamine receptor GPCR AGONIST Ki 8.14 IUPHAR IUPHAR
Alpha-2A adrenergic receptor GPCR Ki 5.73 PDSP
5-hydroxytryptamine receptor 1A GPCR Ki 6.54 WOMBAT-PK
5-hydroxytryptamine receptor 2A GPCR EC50 6.85 CHEMBL
5-hydroxytryptamine receptor 2B GPCR Ki 5.42 PDSP
5-hydroxytryptamine receptor 7 GPCR Ki 5.82 PDSP
Alpha-2B adrenergic receptor GPCR Ki 6.12 WOMBAT-PK
D(3) dopamine receptor GPCR AGONIST Ki 7.43 WOMBAT-PK
D(1B) dopamine receptor GPCR Ki 4.38 CHEMBL
5-hydroxytryptamine receptor 1D GPCR Ki 5.86 PDSP
Alpha-2C adrenergic receptor GPCR Ki 5.92 PDSP
D(4) dopamine receptor GPCR AGONIST Ki 6.07 WOMBAT-PK
D(1A) dopamine receptor GPCR Ki 4.49 CHEMBL
D(2) dopamine receptor GPCR Ki 5.57 CHEMBL
D(2) dopamine receptor GPCR IC50 5.17 CHEMBL
D(3) dopamine receptor GPCR Ki 7.53 CHEMBL

External reference:

IDSource
4024081 VUID
N0000022086 NUI
D00784 KEGG_DRUG
91374-20-8 SECONDARY_CAS_RN
4021058 VANDF
4024081 VANDF
C0244821 UMLSCUI
CHEBI:8888 CHEBI
CHEMBL589 ChEMBL_ID
CHEMBL1200411 ChEMBL_ID
DB00268 DRUGBANK_ID
C046649 MESH_SUPPLEMENTAL_RECORD_UI
5095 PUBCHEM_CID
7295 IUPHAR_LIGAND_ID
6436 INN_ID
030PYR8953 UNII
152951 RXNORM
11369 MMSL
136707 MMSL
5434 MMSL
d04215 MMSL
006273 NDDF
006274 NDDF
108473005 SNOMEDCT_US
108474004 SNOMEDCT_US
372499000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0228-3640 TABLET, FILM COATED, EXTENDED RELEASE 6 mg ORAL ANDA 18 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0228-3658 TABLET, FILM COATED, EXTENDED RELEASE 2 mg ORAL ANDA 18 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0228-3659 TABLET, FILM COATED, EXTENDED RELEASE 4 mg ORAL ANDA 18 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0228-3660 TABLET, FILM COATED, EXTENDED RELEASE 8 mg ORAL ANDA 18 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0228-3661 TABLET, FILM COATED, EXTENDED RELEASE 12 mg ORAL ANDA 18 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0378-5501 TABLET 1 mg ORAL ANDA 28 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0378-5502 TABLET 2 mg ORAL ANDA 28 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0378-5503 TABLET 3 mg ORAL ANDA 28 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0378-5504 TABLET 4 mg ORAL ANDA 28 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0378-5505 TABLET 5 mg ORAL ANDA 28 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0378-5525 TABLET 0.25 mg ORAL ANDA 28 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0378-5550 TABLET 0.50 mg ORAL ANDA 28 sections
ROPINIROLE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0615-8188 TABLET, FILM COATED 0.25 mg ORAL ANDA 26 sections
ROPINIROLE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0615-8189 TABLET, FILM COATED 0.50 mg ORAL ANDA 26 sections
ROPINIROLE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0615-8190 TABLET, FILM COATED 1 mg ORAL ANDA 26 sections
ROPINIROLE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0615-8191 TABLET, FILM COATED 2 mg ORAL ANDA 26 sections
ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0781-5780 TABLET, FILM COATED, EXTENDED RELEASE 2 mg ORAL ANDA 24 sections
ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0781-5782 TABLET, FILM COATED, EXTENDED RELEASE 4 mg ORAL ANDA 24 sections
ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0781-5784 TABLET, FILM COATED, EXTENDED RELEASE 6 mg ORAL ANDA 24 sections
ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0781-5786 TABLET, FILM COATED, EXTENDED RELEASE 8 mg ORAL ANDA 24 sections
ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0781-5788 TABLET, FILM COATED, EXTENDED RELEASE 12 mg ORAL ANDA 24 sections
ROPINIROLE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0904-6373 TABLET, FILM COATED 0.25 mg ORAL ANDA 27 sections
ROPINIROLE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0904-6374 TABLET, FILM COATED 1 mg ORAL ANDA 27 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 10135-673 TABLET, FILM COATED 0.25 mg ORAL ANDA 28 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 10135-674 TABLET, FILM COATED 0.50 mg ORAL ANDA 28 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 10135-675 TABLET, FILM COATED 1 mg ORAL ANDA 28 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 10135-676 TABLET, FILM COATED 2 mg ORAL ANDA 28 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 10135-677 TABLET, FILM COATED 3 mg ORAL ANDA 28 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 10135-678 TABLET, FILM COATED 4 mg ORAL ANDA 28 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 10135-679 TABLET, FILM COATED 5 mg ORAL ANDA 28 sections