ropinirole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2402 91374-21-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ropinirol
  • requip
  • ropinirole
  • ropinirole hydrochloride
  • ropinirole HCl
Ropinirole is a non-ergoline dopamine agonist. The precise mechanism of action of ropinirole as a treatment for Parkinson’s disease is unknown, although it is thought to be related to its ability to stimulate dopamine D2 receptors within the caudate-putamen in the brain.
  • Molecular weight: 260.38
  • Formula: C16H24N2O
  • CLOGP: 2.80
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 32.34
  • ALOGS: -2.87
  • ROTB: 7

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
6 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 133 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 5 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.32 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 55 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 7.70 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 30 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.60 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 6 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Sept. 19, 1997 FDA GLAXOSMITHKLINE LLC
Sept. 20, 2019 PMDA Hisamitsu Pharmaceutical Co., Inc.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Dyskinesia 249.27 12.79 154 24018 31848 63433002
On and off phenomenon 225.90 12.79 64 24108 1771 63463079
Compulsive shopping 192.64 12.79 47 24125 712 63464138
Hallucination 177.03 12.79 155 24017 54662 63410188
Hallucination, visual 160.81 12.79 97 24075 19201 63445649
Dopamine dysregulation syndrome 152.54 12.79 30 24142 150 63464700
Restless legs syndrome 114.19 12.79 77 24095 18454 63446396
Impulse-control disorder 103.81 12.79 29 24143 761 63464089
Full blood count abnormal 96.99 12.79 87 24085 31630 63433220
Bradykinesia 94.57 12.79 44 24128 5144 63459706
Freezing phenomenon 90.18 12.79 29 24143 1243 63463607
Tremor 89.97 12.79 172 24000 132067 63332783
Stoma site discharge 87.57 12.79 30 24142 1568 63463282
Fall 84.85 12.79 334 23838 392000 63072850
Stoma site erythema 82.59 12.79 27 24145 1220 63463630
Gait disturbance 77.65 12.79 197 23975 182981 63281869
Parkinsonism hyperpyrexia syndrome 73.91 12.79 16 24156 137 63464713
Hyperglycaemia 66.70 12.79 81 24091 41786 63423064
Gambling 66.35 12.79 16 24156 230 63464620
Hyperkinesia 63.32 12.79 24 24148 1680 63463170
Gambling disorder 58.98 12.79 21 24151 1231 63463619
Jealous delusion 54.89 12.79 10 24162 30 63464820
Product dose omission issue 51.75 12.79 201 23971 234112 63230738
Memory impairment 48.21 12.79 116 24056 104142 63360708
Treatment failure 47.70 12.79 9 24163 199034 63265816
Gastrooesophageal reflux disease 45.94 12.79 108 24064 95531 63369319
Parkinsonian gait 45.85 12.79 14 24158 505 63464345
Insomnia 45.37 12.79 182 23990 215070 63249780
Glossodynia 45.26 12.79 7 24165 178869 63285981
Delusion 44.94 12.79 37 24135 11980 63452870
Illusion 43.14 12.79 16 24156 1054 63463796
Systemic lupus erythematosus 43.09 12.79 13 24159 208905 63255945
Joint swelling 42.94 12.79 37 24135 327629 63137221
Behaviour disorder 42.89 12.79 22 24150 3177 63461673
Muscle rigidity 42.15 12.79 35 24137 11465 63453385
Infusion related reaction 41.23 12.79 21 24151 245500 63219350
Stoma site pain 40.35 12.79 15 24157 995 63463855
Hepatic enzyme increased 39.24 12.79 14 24158 202314 63262536
Asthma 39.05 12.79 122 24050 127439 63337411
Hypersexuality 37.41 12.79 12 24160 510 63464340
Muscle spasms 36.95 12.79 137 24035 156013 63308837
Abnormal dreams 36.47 12.79 31 24141 10485 63454365
Exposure during pregnancy 35.26 12.79 8 24164 155539 63309311
Binge eating 34.21 12.79 11 24161 471 63464379
Psychotic symptom 34.03 12.79 15 24157 1546 63463304
Drug withdrawal syndrome 32.98 12.79 46 24126 27148 63437702
Type 2 diabetes mellitus 32.72 12.79 74 24098 63794 63401056
Withdrawal syndrome 32.35 12.79 39 24133 19958 63444892
Balance disorder 31.84 12.79 87 24085 84335 63380515
Drug intolerance 31.40 12.79 43 24129 308618 63156232
Dystonia 31.05 12.79 32 24140 13787 63451063
Feeling abnormal 30.86 12.79 125 24047 148267 63316583
Oromandibular dystonia 29.29 12.79 10 24162 517 63464333
Mental impairment 28.65 12.79 31 24141 14120 63450730
Posture abnormal 28.30 12.79 15 24157 2317 63462533
Multiple sclerosis relapse 28.06 12.79 59 24113 48419 63416431
Arthropathy 27.82 12.79 29 24143 234763 63230087
Anxiety 27.64 12.79 159 24013 217382 63247468
Alopecia 26.95 12.79 55 24117 337481 63127369
Parkinsonism 26.82 12.79 26 24146 10413 63454437
Tension 26.54 12.79 16 24156 3159 63461691
Eczema eyelids 26.27 12.79 7 24165 153 63464697
Wound 25.88 12.79 15 24157 163248 63301602
Depression 25.87 12.79 145 24027 196347 63268503
Rapid eye movement sleep behaviour disorder 25.45 12.79 8 24164 318 63464532
Limbic encephalitis 25.33 12.79 8 24164 323 63464527
Multiple sclerosis 24.87 12.79 38 24134 24334 63440516
Fibroma 24.78 12.79 10 24162 827 63464023
Lower respiratory tract infection 24.24 12.79 10 24162 132297 63332553
Toxicity to various agents 23.60 12.79 36 24136 247214 63217636
Rheumatoid arthritis 23.24 12.79 38 24134 253781 63211069
Pleurothotonus 23.22 12.79 11 24161 1338 63463512
Stereotypy 23.06 12.79 8 24164 434 63464416
Urinary tract infection 23.03 12.79 176 23996 264508 63200342
Discomfort 23.01 12.79 18 24154 167356 63297494
Therapy interrupted 23.00 12.79 43 24129 32412 63432438
Therapeutic response unexpected 21.66 12.79 31 24141 18728 63446122
Stoma site infection 21.65 12.79 9 24163 803 63464047
Tardive dyskinesia 21.51 12.79 21 24151 8481 63456369
Dizziness 21.46 12.79 254 23918 429671 63035179
Therapeutic product effect variable 21.14 12.79 10 24162 1213 63463637
Pyrexia 20.96 12.79 100 24072 470378 62994472
Somatic delusion 20.78 12.79 8 24164 584 63464266
Therapeutic response shortened 20.57 12.79 24 24148 11864 63452986
Stomatitis 18.96 12.79 15 24157 138710 63326140
Stoma site reaction 18.84 12.79 6 24166 249 63464601
Irritability 18.83 12.79 39 24133 31655 63433195
Impulsive behaviour 18.69 12.79 10 24162 1573 63463277
Febrile neutropenia 18.60 12.79 11 24161 118438 63346412
Extra dose administered 18.58 12.79 17 24155 6333 63458517
Abnormal behaviour 18.56 12.79 31 24141 21395 63443455
Resting tremor 18.23 12.79 8 24164 815 63464035
Teeth brittle 17.96 12.79 7 24165 528 63464322
Living in residential institution 17.90 12.79 7 24165 533 63464317
Hypersensitivity 17.66 12.79 55 24117 292630 63172220
Abdominal discomfort 17.52 12.79 63 24109 320822 63144028
Somnolence 17.35 12.79 122 24050 178563 63286287
Labelled drug-disease interaction issue 17.33 12.79 4 24168 47 63464803
Major depression 17.00 12.79 18 24154 8000 63456850
Logorrhoea 16.83 12.79 11 24161 2499 63462351
Acute psychosis 16.77 12.79 11 24161 2514 63462336
Pre-existing condition improved 16.58 12.79 18 24154 8226 63456624
Hyperhidrosis 16.52 12.79 83 24089 107753 63357097
Acquired haemophilia 16.51 12.79 8 24164 1023 63463827
Dropped head syndrome 16.28 12.79 5 24167 184 63464666
Akinesia 15.88 12.79 9 24163 1584 63463266
Apathy 15.63 12.79 18 24154 8776 63456074
Muscle injury 15.54 12.79 3 24169 65342 63399508
Primary myelofibrosis 15.49 12.79 4 24168 77 63464773
Dermatitis contact 15.45 12.79 20 24152 10988 63453862
Impaired healing 15.44 12.79 10 24162 102532 63362318
Thrombocytopenia 15.41 12.79 21 24151 151136 63313714
Stoma site irritation 15.31 12.79 5 24167 225 63464625
Off label use 15.21 12.79 174 23998 674288 62790562
Occipital neuralgia 15.07 12.79 6 24166 479 63464371
Nocturia 15.04 12.79 17 24155 8124 63456726
Sleep attacks 15.03 12.79 4 24168 87 63464763
Periodic limb movement disorder 14.83 12.79 5 24167 249 63464601
Spinal operation 14.82 12.79 17 24155 8254 63456596
Palatal swelling 14.74 12.79 4 24168 94 63464756
Somnambulism 14.60 12.79 14 24158 5529 63459321
Stoma complication 14.50 12.79 6 24166 529 63464321
Movement disorder 14.48 12.79 28 24144 21633 63443217
Anaemia 14.48 12.79 60 24112 293370 63171480
Serotonin syndrome 14.43 12.79 33 24139 28649 63436201
Nightmare 14.31 12.79 26 24146 19168 63445682
Sudden onset of sleep 14.31 12.79 6 24166 547 63464303
Basophil percentage increased 14.21 12.79 4 24168 108 63464742
Hospitalisation 14.11 12.79 67 24105 85014 63379836
Camptocormia 13.87 12.79 5 24167 304 63464546
Device issue 13.82 12.79 29 24143 23752 63441098
Ill-defined disorder 13.69 12.79 7 24165 81748 63383102
Clavicle fracture 13.68 12.79 11 24161 3444 63461406
Energy increased 13.63 12.79 10 24162 2737 63462113
Stoma site extravasation 13.62 12.79 5 24167 320 63464530
Poor quality sleep 13.61 12.79 26 24146 19909 63444941
Limb injury 13.58 12.79 30 24142 25447 63439403
Neutropenia 13.54 12.79 29 24143 174976 63289874
Speech disorder 13.48 12.79 40 24132 40589 63424261
Dreamy state 13.44 12.79 3 24169 30 63464820
Insurance issue 13.44 12.79 14 24158 6107 63458743
Cross sensitivity reaction 13.35 12.79 9 24163 2153 63462697
Hypertension 13.23 12.79 58 24114 279245 63185605
Underdose 13.16 12.79 31 24141 27425 63437425
Device occlusion 12.93 12.79 15 24157 7372 63457478
Complement factor C4 increased 12.87 12.79 4 24168 153 63464697
Respiratory dyskinesia 12.87 12.79 3 24169 37 63464813

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hallucination 350.58 15.99 229 13369 51269 34892064
Hypersexuality 295.23 15.99 76 13522 1417 34941916
Impulse-control disorder 265.91 15.99 68 13530 1233 34942100
Dyskinesia 214.41 15.99 124 13474 22289 34921044
Hallucination, visual 204.35 15.99 111 13487 17680 34925653
On and off phenomenon 196.80 15.99 62 13536 2435 34940898
Gambling disorder 194.67 15.99 56 13542 1604 34941729
Freezing phenomenon 180.94 15.99 52 13546 1484 34941849
Dopamine dysregulation syndrome 176.97 15.99 40 13558 416 34942917
Sudden onset of sleep 117.58 15.99 28 13570 372 34942961
Muscle rigidity 110.75 15.99 62 13536 10456 34932877
Somnolence 93.14 15.99 160 13438 110956 34832377
Bradykinesia 89.26 15.99 39 13559 3854 34939479
Jealous delusion 87.29 15.99 21 13577 292 34943041
Compulsive shopping 81.97 15.99 21 13577 383 34942950
Stoma site discharge 78.74 15.99 26 13572 1187 34942146
Fall 76.07 15.99 211 13387 202674 34740659
Stoma site erythema 70.62 15.99 22 13576 831 34942502
Serotonin syndrome 66.56 15.99 58 13540 19875 34923458
Hyperkinesia 65.54 15.99 25 13573 1743 34941590
Delusion 64.10 15.99 47 13551 12588 34930745
Aggression 61.83 15.99 76 13522 38888 34904445
Psychotic disorder 58.28 15.99 59 13539 24393 34918940
Confusional state 53.99 15.99 150 13448 144010 34799323
Balance disorder 53.07 15.99 72 13526 40582 34902751
Device dislocation 52.94 15.99 32 13566 6217 34937116
Stereotypy 52.23 15.99 17 13581 741 34942592
Dropped head syndrome 51.74 15.99 12 13586 141 34943192
Orthostatic hypotension 48.47 15.99 55 13543 25864 34917469
Abnormal dreams 47.29 15.99 32 13566 7546 34935787
Abnormal behaviour 43.35 15.99 51 13547 24918 34918415
Gambling 43.23 15.99 11 13587 195 34943138
Therapeutic product effect variable 41.80 15.99 20 13578 2436 34940897
Parkinsonism hyperpyrexia syndrome 41.08 15.99 9 13589 80 34943253
Compulsive sexual behaviour 41.07 15.99 11 13587 240 34943093
Insomnia 40.73 15.99 110 13488 103797 34839536
Tremor 40.27 15.99 95 13503 82492 34860841
Restless legs syndrome 39.96 15.99 30 13568 8324 34935009
Memory impairment 38.34 15.99 64 13534 43254 34900079
Fibroma 36.33 15.99 11 13587 377 34942956
Alien limb syndrome 34.26 15.99 5 13593 0 34943333
Stoma site pain 33.98 15.99 12 13586 672 34942661
Gait disturbance 32.21 15.99 89 13509 85051 34858282
Compulsions 32.14 15.99 9 13589 233 34943100
Febrile neutropenia 32.11 15.99 7 13591 136842 34806491
Reduced facial expression 31.92 15.99 13 13585 1078 34942255
Libido increased 31.42 15.99 12 13586 839 34942494
Anticholinergic syndrome 30.02 15.99 13 13585 1256 34942077
Stress cardiomyopathy 29.76 15.99 15 13583 2044 34941289
Stoma site hypergranulation 29.43 15.99 8 13590 185 34943148
Impulsive behaviour 29.07 15.99 15 13583 2147 34941186
Tension 28.98 15.99 15 13583 2160 34941173
Drug withdrawal syndrome 28.75 15.99 37 13561 19797 34923536
Nonspecific reaction 28.70 15.99 13 13585 1398 34941935
Irritability 28.15 15.99 41 13557 24649 34918684
Stoma site reaction 27.57 15.99 8 13590 236 34943097
Cognitive disorder 27.56 15.99 44 13554 28649 34914684
Dystonia 27.36 15.99 27 13571 10818 34932515
Middle insomnia 27.26 15.99 22 13576 6780 34936553
Obsessive-compulsive disorder 26.65 15.99 20 13578 5544 34937789
Behaviour disorder 26.57 15.99 19 13579 4891 34938442
Mobility decreased 25.97 15.99 44 13554 30084 34913249
Paraphilia 25.46 15.99 6 13592 76 34943257
Disturbance in attention 25.21 15.99 40 13558 25905 34917428
Suspiciousness 24.98 15.99 8 13590 331 34943002
Diarrhoea 24.79 15.99 74 13524 389838 34553495
Speech disorder 24.13 15.99 39 13559 25647 34917686
Tic 24.04 15.99 13 13585 2045 34941288
Incorrect product dosage form administered 23.92 15.99 7 13591 213 34943120
Agitation 23.71 15.99 62 13536 57337 34885996
Paranoia 23.22 15.99 26 13572 12042 34931291
Mania 22.74 15.99 23 13575 9488 34933845
Progressive supranuclear palsy 22.48 15.99 5 13593 48 34943285
Hypokinesia 22.20 15.99 22 13576 8858 34934475
Torsade de pointes 22.11 15.99 20 13578 7189 34936144
Thunderclap headache 22.06 15.99 6 13592 139 34943194
Stoma site inflammation 21.92 15.99 8 13590 493 34942840
Sexually inappropriate behaviour 21.75 15.99 8 13590 504 34942829
Embedded device 21.10 15.99 7 13591 324 34943009
Neutropenia 21.09 15.99 18 13580 156760 34786573
Generalised onset non-motor seizure 20.98 15.99 4 13594 16 34943317
Hypersomnia 20.96 15.99 25 13573 12382 34930951
Akinesia 20.63 15.99 12 13586 2172 34941161
Product dispensing error 20.42 15.99 18 13580 6256 34937077
Mydriasis 20.10 15.99 19 13579 7218 34936115
Multiple organ dysfunction syndrome 19.92 15.99 3 13595 76563 34866770
Hypomania 19.77 15.99 12 13586 2347 34940986
Bipolar disorder 19.40 15.99 14 13584 3655 34939678
Dysphagia 18.63 15.99 60 13538 62321 34881012
Parkinsonian crisis 18.48 15.99 3 13595 3 34943330
Urinary tract infection 18.38 15.99 73 13525 84008 34859325
Hallucinations, mixed 18.33 15.99 12 13586 2677 34940656
Salivary gland cancer stage IV 18.31 15.99 4 13594 35 34943298
Sleep disorder 18.27 15.99 39 13559 31649 34911684
Medical device discomfort 18.21 15.99 4 13594 36 34943297
Nocturia 17.96 15.99 21 13577 10189 34933144
Malignant neoplasm progression 17.83 15.99 6 13592 88040 34855293
Depressive symptom 17.66 15.99 12 13586 2847 34940486
Gait inability 17.47 15.99 30 13568 20728 34922605
Psychomotor hyperactivity 17.27 15.99 20 13578 9602 34933731
Sleep attacks 17.25 15.99 5 13593 147 34943186
Suicidal ideation 17.05 15.99 44 13554 40344 34902989
Logorrhoea 16.96 15.99 11 13587 2415 34940918
Hyperphagia 16.65 15.99 9 13589 1414 34941919
Toxicity to various agents 16.65 15.99 33 13565 200329 34743004
Pyrexia 16.59 15.99 70 13528 332943 34610390
Oedema peripheral 16.57 15.99 91 13507 119721 34823612
Movement disorder 16.43 15.99 22 13576 12226 34931107

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hallucination 398.14 12.92 297 29437 85448 79629206
Hallucination, visual 352.62 12.92 193 29541 32536 79682118
Dyskinesia 341.59 12.92 211 29523 44562 79670092
Dopamine dysregulation syndrome 331.14 12.92 68 29666 449 79714205
On and off phenomenon 307.96 12.92 92 29642 3148 79711506
Impulse-control disorder 304.39 12.92 80 29654 1694 79712960
Hypersexuality 223.57 12.92 62 29672 1618 79713036
Freezing phenomenon 220.05 12.92 63 29671 1851 79712803
Compulsive shopping 200.35 12.92 49 29685 767 79713887
Gambling disorder 190.25 12.92 57 29677 1969 79712685
Jealous delusion 140.54 12.92 31 29703 299 79714355
Fall 138.11 12.92 447 29287 487182 79227472
Bradykinesia 134.94 12.92 64 29670 7979 79706675
Parkinsonism hyperpyrexia syndrome 115.10 12.92 25 29709 223 79714431
Hyperkinesia 111.59 12.92 41 29693 2688 79711966
Stoma site discharge 108.45 12.92 38 29696 2171 79712483
Muscle rigidity 101.45 12.92 73 29661 19809 79694845
Stoma site erythema 101.03 12.92 34 29700 1719 79712935
Restless legs syndrome 91.76 12.92 69 29665 20023 79694631
Delusion 90.75 12.92 69 29665 20354 79694300
Tremor 88.87 12.92 196 29538 169887 79544767
Gait disturbance 85.53 12.92 218 29516 207288 79507366
Gambling 83.84 12.92 20 29714 280 79714374
Full blood count abnormal 78.84 12.92 86 29648 40388 79674266
Behaviour disorder 75.69 12.92 40 29694 6273 79708381
Somnolence 73.76 12.92 226 29508 238755 79475899
Sudden onset of sleep 73.14 12.92 21 29713 623 79714031
Serotonin syndrome 73.00 12.92 87 29647 44940 79669714
Stereotypy 65.20 12.92 21 29713 924 79713730
Dystonia 65.07 12.92 58 29676 21341 79693313
Drug withdrawal syndrome 62.84 12.92 71 29663 34647 79680007
Aggression 61.42 12.92 85 29649 50873 79663781
Insomnia 57.99 12.92 212 29522 244958 79469696
Irritability 54.72 12.92 72 29662 41072 79673582
Therapeutic product effect variable 53.12 12.92 22 29712 1987 79712667
Dropped head syndrome 51.91 12.92 14 29720 328 79714326
Abnormal dreams 51.68 12.92 39 29695 11373 79703281
Psychotic disorder 49.80 12.92 69 29665 41333 79673321
Balance disorder 47.22 12.92 110 29624 98747 79615907
Impulsive behaviour 45.37 12.92 22 29712 2878 79711776
Withdrawal syndrome 43.71 12.92 52 29682 26802 79687852
Memory impairment 43.52 12.92 115 29619 111619 79603035
Abnormal behaviour 42.76 12.92 60 29674 36361 79678293
Illusion 42.46 12.92 18 29716 1723 79712931
Binge eating 42.14 12.92 13 29721 496 79714158
Febrile neutropenia 40.03 12.92 18 29716 230981 79483673
Product dose omission issue 39.64 12.92 190 29544 247347 79467307
Orthostatic hypotension 39.14 12.92 73 29661 56091 79658563
Treatment failure 39.04 12.92 8 29726 170478 79544176
Type 2 diabetes mellitus 38.27 12.92 73 29661 57049 79657605
Muscle spasms 37.88 12.92 147 29587 174583 79540071
Parkinsonian gait 37.86 12.92 14 29720 934 79713720
Psychotic symptom 37.85 12.92 19 29715 2678 79711976
Toxicity to various agents 36.73 12.92 63 29671 421477 79293177
Feeling abnormal 36.21 12.92 136 29598 159063 79555591
Confusional state 35.98 12.92 222 29512 317775 79396879
Hyperglycaemia 35.50 12.92 80 29654 70255 79644399
Hepatic enzyme increased 35.31 12.92 12 29722 182598 79532056
Stoma site pain 35.31 12.92 15 29719 1443 79713211
Pyrexia 33.47 12.92 135 29599 678574 79036080
Gastrooesophageal reflux disease 32.49 12.92 99 29635 104147 79610507
Logorrhoea 31.81 12.92 20 29714 4345 79710309
Tension 31.64 12.92 20 29714 4384 79710270
Product dispensing error 30.86 12.92 31 29703 13232 79701422
Parkinsonian crisis 30.53 12.92 5 29729 6 79714648
Parkinsonism 30.15 12.92 34 29700 16550 79698104
Oromandibular dystonia 29.38 12.92 12 29722 1046 79713608
Energy increased 28.96 12.92 17 29717 3265 79711389
Infusion related reaction 28.85 12.92 26 29708 230211 79484443
Akinesia 28.82 12.92 17 29717 3295 79711359
Progressive supranuclear palsy 27.97 12.92 7 29727 121 79714533
Acute psychosis 27.60 12.92 18 29716 4162 79710492
Speech disorder 27.55 12.92 62 29672 54383 79660271
Disturbance in attention 27.00 12.92 59 29675 50742 79663912
Tardive dyskinesia 27.00 12.92 26 29708 10545 79704109
Rheumatoid arthritis 26.77 12.92 23 29711 208447 79506207
Rapid eye movement sleep behaviour disorder 26.70 12.92 9 29725 457 79714197
Somatic delusion 26.47 12.92 10 29724 708 79713946
Obsessive-compulsive disorder 26.27 12.92 20 29714 5907 79708747
Middle insomnia 25.96 12.92 31 29703 16038 79698616
Hand deformity 25.69 12.92 4 29730 103915 79610739
Hallucinations, mixed 25.67 12.92 21 29713 6878 79707776
Asthma 25.57 12.92 109 29625 134986 79579668
Sleep attacks 25.41 12.92 7 29727 178 79714476
Drug intolerance 25.32 12.92 37 29697 264082 79450572
Joint swelling 25.25 12.92 43 29691 288603 79426051
Eczema eyelids 25.19 12.92 7 29727 184 79714470
Movement disorder 24.98 12.92 40 29694 27219 79687435
Anxiety 24.72 12.92 168 29566 248344 79466310
Nonspecific reaction 24.70 12.92 14 29720 2518 79712136
Urinary tract infection 24.64 12.92 181 29553 274331 79440323
Hyperphagia 24.60 12.92 14 29720 2538 79712116
Hypomania 24.04 12.92 21 29713 7523 79707131
Compulsions 23.85 12.92 8 29726 400 79714254
Dementia 23.72 12.92 37 29697 24622 79690032
Multiple sclerosis relapse 23.56 12.92 53 29681 46480 79668174
Systemic lupus erythematosus 23.35 12.92 8 29726 121141 79593513
Dizziness 23.30 12.92 299 29435 526142 79188512
Neutropenia 23.25 12.92 45 29689 287665 79426989
Multiple organ dysfunction syndrome 23.07 12.92 8 29726 120238 79594416
Compulsive sexual behaviour 23.00 12.92 7 29727 255 79714399
Malignant neoplasm progression 22.92 12.92 11 29723 135979 79578675
Exposure during pregnancy 22.62 12.92 5 29729 101127 79613527
Lower respiratory tract infection 22.48 12.92 10 29724 129210 79585444
Resting tremor 22.19 12.92 11 29723 1510 79713144
Pleurothotonus 22.12 12.92 13 29721 2503 79712151
Libido increased 22.08 12.92 12 29722 1989 79712665
Incorrect product dosage form administered 21.91 12.92 7 29727 300 79714354
Sexually inappropriate behaviour 21.59 12.92 8 29726 537 79714117
Posture abnormal 21.58 12.92 15 29719 3851 79710803
Nocturia 21.45 12.92 26 29708 13655 79700999
Medical device site dryness 21.37 12.92 5 29729 64 79714590
Fibroma 20.99 12.92 9 29725 886 79713768
Reduced facial expression 20.98 12.92 13 29721 2752 79711902
Apathy 20.90 12.92 25 29709 12952 79701702
Hypersensitivity 20.34 12.92 42 29692 262197 79452457
Suspiciousness 20.25 12.92 8 29726 639 79714015
Psychomotor hyperactivity 20.14 12.92 28 29706 16821 79697833
Agitation 20.07 12.92 82 29652 99633 79615021
Therapeutic response shortened 19.92 12.92 27 29707 15836 79698818
Nightmare 19.77 12.92 35 29699 25826 79688828
Off label use 19.74 12.92 230 29504 906985 78807669
Device dislocation 19.67 12.92 35 29699 25935 79688719
Glossodynia 19.61 12.92 7 29727 103330 79611324
Therapeutic response unexpected 19.29 12.92 30 29704 19916 79694738
Stoma site infection 19.27 12.92 10 29724 1510 79713144
Pancytopenia 19.27 12.92 20 29714 165725 79548929
Obsessive thoughts 18.96 12.92 9 29725 1123 79713531
Depression 18.90 12.92 142 29592 216648 79498006
Camptocormia 18.73 12.92 7 29727 481 79714173
Cognitive disorder 18.68 12.92 63 29671 69863 79644791
Hypersomnia 18.64 12.92 32 29702 23054 79691600
Inflammation 18.40 12.92 6 29728 93747 79620907
Stoma site irritation 18.39 12.92 6 29728 275 79714379
Persecutory delusion 18.39 12.92 15 29719 4894 79709760
Rash 18.00 12.92 134 29600 578224 79136430
Limbic encephalitis 17.92 12.92 8 29726 867 79713787
Hyperhidrosis 17.88 12.92 107 29627 151385 79563269
Anticholinergic syndrome 17.83 12.92 13 29721 3598 79711056
Interstitial lung disease 17.66 12.92 10 29724 112590 79602064
Hypokinesia 17.51 12.92 28 29706 19032 79695622
Labelled drug-disease interaction issue 17.41 12.92 4 29730 47 79714607
Dermatitis contact 17.35 12.92 21 29713 11012 79703642
Cerebral atrophy 17.20 12.92 18 29716 8057 79706597
Paranoia 17.10 12.92 28 29706 19404 79695250
Mania 17.01 12.92 27 29707 18233 79696421
Hypertonia 17.00 12.92 17 29717 7215 79707439
Stomatitis 16.73 12.92 18 29716 146739 79567915
Periodic limb movement disorder 16.62 12.92 5 29729 175 79714479
Diarrhoea 16.62 12.92 230 29504 880259 78834395
Extra dose administered 16.59 12.92 18 29716 8397 79706257
Poor quality sleep 16.41 12.92 30 29704 22692 79691962
Thrombocytopenia 16.25 12.92 48 29686 265211 79449443
Thunderclap headache 16.25 12.92 6 29728 399 79714255
Restlessness 16.24 12.92 46 29688 46446 79668208
Mental impairment 16.18 12.92 27 29707 19009 79695645
Device occlusion 16.13 12.92 21 29713 11845 79702809
Salivary gland cancer stage IV 16.04 12.92 4 29730 68 79714586
Patient elopement 15.88 12.92 4 29730 71 79714583
Neuroleptic malignant syndrome 15.79 12.92 33 29701 27526 79687128
Stress cardiomyopathy 15.56 12.92 20 29714 11146 79703508
Generalised onset non-motor seizure 15.53 12.92 4 29730 78 79714576
Prescribed underdose 15.37 12.92 34 29700 29480 79685174
Limb injury 15.36 12.92 34 29700 29494 79685160
Postural reflex impairment 15.31 12.92 3 29731 15 79714639
Occipital neuralgia 15.30 12.92 6 29728 470 79714184
Neutrophil count decreased 15.23 12.92 8 29726 93951 79620703
Renal impairment 15.22 12.92 22 29712 157761 79556893
Stoma site odour 15.11 12.92 4 29730 87 79714567
Teeth brittle 15.02 12.92 6 29728 494 79714160
Dependence 14.95 12.92 10 29724 2412 79712242
Anaemia 14.86 12.92 101 29633 444914 79269740
Alopecia 14.80 12.92 41 29693 231314 79483340
Wound 14.69 12.92 13 29721 116166 79598488
Hallucination, auditory 14.54 12.92 27 29707 20666 79693988
Dysstasia 14.49 12.92 32 29702 27714 79686940
Somnambulism 14.48 12.92 14 29720 5707 79708947
Increased appetite 14.45 12.92 20 29714 11958 79702696
Arthralgia 14.41 12.92 140 29594 571663 79142991
Hypertension 14.35 12.92 69 29665 330923 79383731
Neutrophil count increased 14.34 12.92 33 29701 29363 79685291
Aphasia 14.19 12.92 44 29690 46688 79667966
Wrong product administered 13.92 12.92 17 29717 8995 79705659
Device issue 13.86 12.92 31 29703 27077 79687577
Underdose 13.80 12.92 35 29699 33116 79681538
Blood pressure systolic increased 13.66 12.92 4 29730 66982 79647672
Dysphagia 13.61 12.92 85 29649 122051 79592603
Device connection issue 13.59 12.92 7 29727 1041 79713613
Obsessive-compulsive personality disorder 13.55 12.92 4 29730 131 79714523
Female orgasmic disorder 13.41 12.92 3 29731 31 79714623
Sleep talking 13.30 12.92 7 29727 1089 79713565
Suicidal ideation 13.22 12.92 60 29674 76280 79638374
Salivary hypersecretion 13.21 12.92 21 29713 14203 79700451
Stoma site extravasation 13.16 12.92 5 29729 360 79714294
Gait inability 13.10 12.92 50 29684 58867 79655787
Tic 13.07 12.92 10 29724 2976 79711678
Surgery 13.02 12.92 34 29700 32732 79681922
Living in residential institution 12.99 12.92 6 29728 704 79713950
Swelling of eyelid 12.93 12.92 11 29723 3800 79710854

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N04BC04 NERVOUS SYSTEM
ANTI-PARKINSON DRUGS
DOPAMINERGIC AGENTS
Dopamine agonists
FDA MoA N0000000117 Dopamine Agonists
MeSH PA D018726 Anti-Dyskinesia Agents
MeSH PA D000978 Antiparkinson Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D015259 Dopamine Agents
MeSH PA D018491 Dopamine Agonists
MeSH PA D018377 Neurotransmitter Agents
CHEBI has role CHEBI:35470 central nervous system agents
CHEBI has role CHEBI:48407 antiparkinson agent
CHEBI has role CHEBI:51065 Dopamine receptor agonist
CHEBI has role CHEBI:66956 antidyskinetic agent
FDA EPC N0000175768 Nonergot Dopamine Agonist

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Restless legs indication 32914008 DOID:0050425
Parkinson's disease indication 49049000 DOID:14330
Hallucinations contraindication 7011001
Dyskinesia contraindication 9748009
Orthostatic hypotension contraindication 28651003
Low blood pressure contraindication 45007003
Bradycardia contraindication 48867003
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Psychotic disorder contraindication 69322001
Syncope contraindication 271594007
Drowsy contraindication 271782001
Central nervous system depression contraindication 418072004
Smokes tobacco daily contraindication 449868002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

ProductApplicantIngredients
CLEVOR Orion Corp. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.82 acidic
pKa2 9.18 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(2) dopamine receptor GPCR AGONIST Ki 8.14 IUPHAR IUPHAR
Alpha-2A adrenergic receptor GPCR Ki 5.73 PDSP
5-hydroxytryptamine receptor 1A GPCR Ki 6.54 WOMBAT-PK
5-hydroxytryptamine receptor 2A GPCR EC50 6.85 CHEMBL
5-hydroxytryptamine receptor 2B GPCR Ki 5.42 PDSP
5-hydroxytryptamine receptor 7 GPCR Ki 5.82 PDSP
Alpha-2B adrenergic receptor GPCR Ki 6.12 WOMBAT-PK
D(3) dopamine receptor GPCR AGONIST Ki 7.43 WOMBAT-PK
D(1B) dopamine receptor GPCR Ki 4.38 CHEMBL
5-hydroxytryptamine receptor 1D GPCR Ki 5.86 PDSP
Alpha-2C adrenergic receptor GPCR Ki 5.92 PDSP
D(4) dopamine receptor GPCR AGONIST Ki 6.07 WOMBAT-PK
D(1A) dopamine receptor GPCR Ki 4.49 CHEMBL
D(2) dopamine receptor GPCR Ki 5.57 CHEMBL
D(2) dopamine receptor GPCR IC50 5.17 CHEMBL
D(3) dopamine receptor GPCR Ki 7.53 CHEMBL

External reference:

IDSource
4024081 VUID
N0000022086 NUI
D00784 KEGG_DRUG
91374-20-8 SECONDARY_CAS_RN
4021058 VANDF
4024081 VANDF
C0244821 UMLSCUI
CHEBI:8888 CHEBI
CHEMBL589 ChEMBL_ID
CHEMBL1200411 ChEMBL_ID
DB00268 DRUGBANK_ID
C046649 MESH_SUPPLEMENTAL_RECORD_UI
5095 PUBCHEM_CID
7295 IUPHAR_LIGAND_ID
6436 INN_ID
030PYR8953 UNII
152951 RXNORM
11369 MMSL
136707 MMSL
25995 MMSL
5434 MMSL
d04215 MMSL
006273 NDDF
006274 NDDF
108473005 SNOMEDCT_US
108474004 SNOMEDCT_US
372499000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0228-3640 TABLET, FILM COATED, EXTENDED RELEASE 6 mg ORAL ANDA 18 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0228-3640 TABLET, FILM COATED, EXTENDED RELEASE 6 mg ORAL ANDA 18 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0228-3658 TABLET, FILM COATED, EXTENDED RELEASE 2 mg ORAL ANDA 18 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0228-3658 TABLET, FILM COATED, EXTENDED RELEASE 2 mg ORAL ANDA 18 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0228-3659 TABLET, FILM COATED, EXTENDED RELEASE 4 mg ORAL ANDA 18 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0228-3659 TABLET, FILM COATED, EXTENDED RELEASE 4 mg ORAL ANDA 18 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0228-3660 TABLET, FILM COATED, EXTENDED RELEASE 8 mg ORAL ANDA 18 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0228-3660 TABLET, FILM COATED, EXTENDED RELEASE 8 mg ORAL ANDA 18 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0228-3661 TABLET, FILM COATED, EXTENDED RELEASE 12 mg ORAL ANDA 18 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0228-3661 TABLET, FILM COATED, EXTENDED RELEASE 12 mg ORAL ANDA 18 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0378-5501 TABLET 1 mg ORAL ANDA 28 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0378-5501 TABLET 1 mg ORAL ANDA 28 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0378-5502 TABLET 2 mg ORAL ANDA 28 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0378-5502 TABLET 2 mg ORAL ANDA 28 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0378-5503 TABLET 3 mg ORAL ANDA 28 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0378-5503 TABLET 3 mg ORAL ANDA 28 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0378-5504 TABLET 4 mg ORAL ANDA 28 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0378-5504 TABLET 4 mg ORAL ANDA 28 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0378-5505 TABLET 5 mg ORAL ANDA 28 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0378-5505 TABLET 5 mg ORAL ANDA 28 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0378-5525 TABLET 0.25 mg ORAL ANDA 28 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0378-5525 TABLET 0.25 mg ORAL ANDA 28 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0378-5550 TABLET 0.50 mg ORAL ANDA 28 sections
Ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0378-5550 TABLET 0.50 mg ORAL ANDA 28 sections
ROPINIROLE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0615-8188 TABLET, FILM COATED 0.25 mg ORAL ANDA 26 sections
ROPINIROLE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0615-8189 TABLET, FILM COATED 0.50 mg ORAL ANDA 26 sections
ROPINIROLE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0615-8190 TABLET, FILM COATED 1 mg ORAL ANDA 26 sections
ROPINIROLE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0615-8191 TABLET, FILM COATED 2 mg ORAL ANDA 26 sections
ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0781-5780 TABLET, FILM COATED, EXTENDED RELEASE 2 mg ORAL ANDA 24 sections
ropinirole HUMAN PRESCRIPTION DRUG LABEL 1 0781-5780 TABLET, FILM COATED, EXTENDED RELEASE 2 mg ORAL ANDA 24 sections