rocuronium Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
neuromuscular blocking agents with rigid structure 2396 119302-91-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ORG-9426
  • ORG 9426
  • rocuronium
  • rocuronium bromide
  • zemuron
  • esmeron
Rocuronium bromide is a nondepolarizing neuromuscular blocking agent with a rapid to intermediate onset depending on dose and intermediate duration. It acts by competing for cholinergic receptors at the motor end-plate. This action is antagonized by acetylcholinesterase inhibitors, such as neostigmine and edrophonium.
  • Molecular weight: 529.79
  • Formula: C32H53N2O4
  • CLOGP: 2.43
  • LIPINSKI: 1
  • HAC: 6
  • HDO: 1
  • TPSA: 59
  • ALOGS: -7.30
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 17 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.38 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.21 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 3.70 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.54 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.60 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
March 17, 1994 FDA ORGANON USA INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaphylactic reaction 1429.76 167.44 284 1062 9421 2347318
Anaphylactic shock 711.82 167.44 140 1206 4146 2352593
Hypotension 514.24 167.44 160 1186 32276 2324463
Neuromuscular block prolonged 480.33 167.44 61 1285 50 2356689
Cardiac arrest 479.77 167.44 128 1218 14802 2341937
Bronchospasm 477.65 167.44 95 1251 2929 2353810
Tachycardia 335.53 167.44 99 1247 16310 2340429
Circulatory collapse 304.48 167.44 68 1278 3652 2353087
Delayed recovery from anaesthesia 190.56 167.44 29 1317 163 2356576
Oxygen saturation decreased 177.38 167.44 51 1295 7535 2349204

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaphylactic reaction 722.56 132.83 157 906 5956 1739762
Anaphylactic shock 576.64 132.83 115 948 2784 1742934
Hypotension 334.33 132.83 121 942 29533 1716185
Neuromuscular block prolonged 234.72 132.83 31 1032 27 1745691
Bronchospasm 213.14 132.83 48 1015 2034 1743684
Cardiac arrest 208.31 132.83 73 990 15857 1729861
Hyperthermia malignant 167.31 132.83 29 1034 300 1745418

Pharmacologic Action:

SourceCodeDescription
ATC M03AC09 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, PERIPHERALLY ACTING AGENTS
Other quaternary ammonium compounds
FDA PE N0000175732 Neuromuscular Nondepolarizing Blockade
FDA EPC N0000175720 Nondepolarizing Neuromuscular Blocker
MeSH PA D009465 Neuromuscular Agents
MeSH PA D009466 Neuromuscular Blocking Agents
MeSH PA D003473 Neuromuscular Nondepolarizing Agents
MeSH PA D018373 Peripheral Nervous System Agents
CHEBI has role CHEBI:51372 neuromuscular agent
CHEBI has role CHEBI:51371 muscle relaxant

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Muscle relaxation, function indication 11977004
General anesthesia indication 50697003
Skeletal Muscle Relaxation for Endotracheal Intubation indication
Respiratory acidosis contraindication 12326000
Alkalosis contraindication 21420006
Acidosis contraindication 51387008
Eaton-Lambert syndrome contraindication 56989000 DOID:0050214
Pulmonary hypertension contraindication 70995007 DOID:6432
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Respiratory alkalosis contraindication 111378004
Disease of liver contraindication 235856003 DOID:409
Disorder of electrolytes contraindication 237840007
Malignant hyperthermia contraindication 405501007

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.61 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Acetylcholine receptor Ion channel ANTAGONIST IC50 7.77 WOMBAT-PK CHEMBL
Acetylcholine receptor; alpha1/beta1/delta/gamma Ion channel IC50 7.09 CHEMBL

External reference:

IDSource
D000077123 MESH_DESCRIPTOR_UI
C0209337 UMLSCUI
D00765 KEGG_DRUG
108449002 SNOMEDCT_US
013418 NDDF
372494005 SNOMEDCT_US
68139 RXNORM
d03766 MMSL
DB00728 DRUGBANK_ID
CHEMBL1200648 ChEMBL_ID
I65MW4OFHZ UNII
6864 INN_ID
CHEBI:8885 CHEBI
CHEMBL1201244 ChEMBL_ID
441290 PUBCHEM_CID
4003 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0143-9250 INJECTION 10 mg INTRAVENOUS ANDA 17 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0143-9251 INJECTION 10 mg INTRAVENOUS ANDA 17 sections
ROCURONIUM BROMIDE HUMAN PRESCRIPTION DRUG LABEL 1 0409-9558 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 17 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0781-3220 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 17 sections
rocuronium bromide HUMAN PRESCRIPTION DRUG LABEL 1 25021-662 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 17 sections
rocuronium bromide HUMAN PRESCRIPTION DRUG LABEL 1 39822-4200 SOLUTION 10 mg INTRAVENOUS ANDA 18 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 43066-007 INJECTION 50 mg INTRAVENOUS ANDA 17 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 43066-013 INJECTION 100 mg INTRAVENOUS ANDA 17 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 47781-616 INJECTION 10 mg INTRAVENOUS ANDA 16 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 47781-617 INJECTION 10 mg INTRAVENOUS ANDA 16 sections
ROCURONIUM BROMIDE HUMAN PRESCRIPTION DRUG LABEL 1 51662-1354 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 17 sections
ROCURONIUM BROMIDE HUMAN PRESCRIPTION DRUG LABEL 1 51662-1355 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 17 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 55150-225 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 17 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 55150-226 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 17 sections
Rocuronium HUMAN PRESCRIPTION DRUG LABEL 1 63323-426 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 17 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 67457-228 INJECTION 10 mg INTRAVENOUS ANDA 17 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 68083-364 INJECTION 10 mg INTRAVENOUS ANDA 17 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 68083-365 INJECTION 10 mg INTRAVENOUS ANDA 17 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 70860-651 SOLUTION 10 mg INTRAVENOUS ANDA 17 sections
Rocuronium bromide HUMAN PRESCRIPTION DRUG LABEL 1 71479-004 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 18 sections
Rocuronium bromide HUMAN PRESCRIPTION DRUG LABEL 1 71479-005 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 18 sections
rocuronium bromide HUMAN PRESCRIPTION DRUG LABEL 1 71872-7036 SOLUTION 10 mg INTRAVENOUS ANDA 17 sections
rocuronium bromide HUMAN PRESCRIPTION DRUG LABEL 1 71872-7202 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 17 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 71872-7207 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 17 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 72611-756 INJECTION 10 mg INTRAVENOUS ANDA 17 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 72611-757 INJECTION 10 mg INTRAVENOUS ANDA 17 sections