Stem definition | Drug id | CAS RN |
---|---|---|
HIV protease inhibitors | 2391 | 155213-67-5 |
Dose | Unit | Route |
---|---|---|
1.20 | g | O |
0.80 | g | O |
0.30 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 3.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 23.78 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 70 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
March 1, 1996 | FDA | ABBVIE | |
Aug. 25, 1996 | EMA | AbbVie Deutschland GmbH Co. KG | |
Feb. 10, 2022 | PMDA | PFIZER JAPAN INC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Exposure during pregnancy | 1679.59 | 17.68 | 846 | 18408 | 120169 | 50465701 |
Foetal exposure during pregnancy | 1610.15 | 17.68 | 540 | 18714 | 26819 | 50559051 |
Abortion spontaneous | 1472.78 | 17.68 | 564 | 18690 | 41208 | 50544662 |
Maternal exposure during pregnancy | 891.18 | 17.68 | 621 | 18633 | 159157 | 50426713 |
Premature baby | 613.98 | 17.68 | 239 | 19015 | 18098 | 50567772 |
Stillbirth | 601.93 | 17.68 | 178 | 19076 | 5774 | 50580096 |
Abortion induced | 590.41 | 17.68 | 195 | 19059 | 9149 | 50576721 |
Live birth | 539.15 | 17.68 | 211 | 19043 | 16197 | 50569673 |
Drug interaction | 500.20 | 17.68 | 488 | 18766 | 199133 | 50386737 |
Premature delivery | 390.10 | 17.68 | 187 | 19067 | 23476 | 50562394 |
Foetal death | 347.53 | 17.68 | 127 | 19127 | 8053 | 50577817 |
Caesarean section | 347.05 | 17.68 | 152 | 19102 | 15487 | 50570383 |
Pregnancy | 300.76 | 17.68 | 169 | 19085 | 29408 | 50556462 |
Premature labour | 259.32 | 17.68 | 113 | 19141 | 11363 | 50574507 |
Virologic failure | 250.20 | 17.68 | 67 | 19187 | 1497 | 50584373 |
Premature rupture of membranes | 231.87 | 17.68 | 81 | 19173 | 4499 | 50581371 |
Immune reconstitution inflammatory syndrome | 224.50 | 17.68 | 83 | 19171 | 5433 | 50580437 |
Foetal growth restriction | 206.20 | 17.68 | 82 | 19172 | 6545 | 50579325 |
Spina bifida | 191.49 | 17.68 | 46 | 19208 | 651 | 50585219 |
Lipodystrophy acquired | 162.05 | 17.68 | 46 | 19208 | 1283 | 50584587 |
CD4 lymphocytes decreased | 161.70 | 17.68 | 46 | 19208 | 1293 | 50584577 |
Hyperbilirubinaemia | 155.66 | 17.68 | 75 | 19179 | 9495 | 50576375 |
Cushing's syndrome | 148.69 | 17.68 | 37 | 19217 | 611 | 50585259 |
Treatment noncompliance | 143.64 | 17.68 | 107 | 19147 | 30043 | 50555827 |
Drug ineffective | 141.76 | 17.68 | 68 | 19186 | 819265 | 49766605 |
Blood HIV RNA increased | 139.38 | 17.68 | 34 | 19220 | 515 | 50585355 |
Viral load increased | 136.16 | 17.68 | 39 | 19215 | 1124 | 50584746 |
Ventricular septal defect | 129.19 | 17.68 | 51 | 19203 | 3990 | 50581880 |
Fanconi syndrome acquired | 126.45 | 17.68 | 35 | 19219 | 888 | 50584982 |
Pre-eclampsia | 118.72 | 17.68 | 59 | 19195 | 7985 | 50577885 |
Low birth weight baby | 117.04 | 17.68 | 53 | 19201 | 5828 | 50580042 |
Adrenal suppression | 110.01 | 17.68 | 31 | 19223 | 841 | 50585029 |
Pain | 109.49 | 17.68 | 42 | 19212 | 578861 | 50007009 |
Polydactyly | 108.96 | 17.68 | 25 | 19229 | 286 | 50585584 |
Gestational diabetes | 107.94 | 17.68 | 54 | 19200 | 7411 | 50578459 |
Polyhydramnios | 107.06 | 17.68 | 37 | 19217 | 1988 | 50583882 |
Congenital anomaly | 105.10 | 17.68 | 34 | 19220 | 1487 | 50584383 |
Trisomy 21 | 104.05 | 17.68 | 25 | 19229 | 354 | 50585516 |
Cerebral ventricle dilatation | 98.94 | 17.68 | 29 | 19225 | 908 | 50584962 |
Maternal drugs affecting foetus | 98.65 | 17.68 | 45 | 19209 | 5032 | 50580838 |
Congenital naevus | 98.63 | 17.68 | 21 | 19233 | 165 | 50585705 |
Placenta praevia | 89.96 | 17.68 | 27 | 19227 | 919 | 50584951 |
Normal newborn | 89.73 | 17.68 | 46 | 19208 | 6645 | 50579225 |
Fatigue | 89.47 | 17.68 | 83 | 19171 | 707518 | 49878352 |
Pathogen resistance | 87.74 | 17.68 | 43 | 19211 | 5646 | 50580224 |
Viral mutation identified | 87.03 | 17.68 | 30 | 19224 | 1599 | 50584271 |
Low set ears | 85.54 | 17.68 | 20 | 19234 | 250 | 50585620 |
Drug resistance | 85.11 | 17.68 | 65 | 19189 | 18924 | 50566946 |
Fall | 82.85 | 17.68 | 14 | 19240 | 334918 | 50250952 |
Supernumerary nipple | 81.62 | 17.68 | 15 | 19239 | 48 | 50585822 |
Acoustic stimulation tests abnormal | 81.36 | 17.68 | 16 | 19238 | 80 | 50585790 |
Joint swelling | 80.23 | 17.68 | 3 | 19251 | 245283 | 50340587 |
Hepatocellular injury | 73.19 | 17.68 | 68 | 19186 | 25879 | 50559991 |
Secondary adrenocortical insufficiency | 72.71 | 17.68 | 24 | 19230 | 1119 | 50584751 |
Cholestasis of pregnancy | 68.95 | 17.68 | 23 | 19231 | 1108 | 50584762 |
Renal tubular disorder | 68.36 | 17.68 | 28 | 19226 | 2409 | 50583461 |
Patent ductus arteriosus | 65.34 | 17.68 | 31 | 19223 | 3789 | 50582081 |
Congenital hydrocephalus | 63.86 | 17.68 | 14 | 19240 | 128 | 50585742 |
Trisomy 18 | 62.00 | 17.68 | 11 | 19243 | 27 | 50585843 |
Nasopharyngitis | 60.94 | 17.68 | 3 | 19251 | 192924 | 50392946 |
Renal colic | 59.71 | 17.68 | 21 | 19233 | 1188 | 50584682 |
Meconium stain | 59.44 | 17.68 | 14 | 19240 | 181 | 50585689 |
Dysmorphism | 57.74 | 17.68 | 24 | 19230 | 2143 | 50583727 |
Macrocephaly | 57.16 | 17.68 | 11 | 19243 | 48 | 50585822 |
Congenital choroid plexus cyst | 57.10 | 17.68 | 15 | 19239 | 310 | 50585560 |
Ergot poisoning | 56.97 | 17.68 | 12 | 19242 | 89 | 50585781 |
Eosinophilia | 56.73 | 17.68 | 51 | 19203 | 18601 | 50567269 |
Cloacal exstrophy | 56.56 | 17.68 | 13 | 19241 | 150 | 50585720 |
Premature separation of placenta | 56.53 | 17.68 | 22 | 19232 | 1656 | 50584214 |
Umbilical cord abnormality | 56.43 | 17.68 | 17 | 19237 | 586 | 50585284 |
Lipohypertrophy | 56.15 | 17.68 | 17 | 19237 | 596 | 50585274 |
Neural tube defect | 54.44 | 17.68 | 13 | 19241 | 179 | 50585691 |
Anal atresia | 54.36 | 17.68 | 15 | 19239 | 376 | 50585494 |
Cushingoid | 54.33 | 17.68 | 33 | 19221 | 6612 | 50579258 |
HIV infection | 54.21 | 17.68 | 14 | 19240 | 270 | 50585600 |
Twin pregnancy | 53.70 | 17.68 | 19 | 19235 | 1094 | 50584776 |
Atrial septal defect | 53.16 | 17.68 | 32 | 19222 | 6309 | 50579561 |
Retinoblastoma | 53.03 | 17.68 | 11 | 19243 | 75 | 50585795 |
Amniotic cavity infection | 52.89 | 17.68 | 19 | 19235 | 1144 | 50584726 |
Tethered cord syndrome | 51.83 | 17.68 | 13 | 19241 | 222 | 50585648 |
Bladder agenesis | 51.77 | 17.68 | 12 | 19242 | 144 | 50585726 |
Foetal distress syndrome | 51.62 | 17.68 | 19 | 19235 | 1226 | 50584644 |
Genitalia external ambiguous | 51.25 | 17.68 | 12 | 19242 | 151 | 50585719 |
Swelling | 50.49 | 17.68 | 8 | 19246 | 200864 | 50385006 |
Caudal regression syndrome | 50.47 | 17.68 | 12 | 19242 | 162 | 50585708 |
Coloboma | 49.90 | 17.68 | 10 | 19244 | 56 | 50585814 |
Fanconi syndrome | 49.57 | 17.68 | 18 | 19236 | 1118 | 50584752 |
Congenital heart valve disorder | 48.11 | 17.68 | 10 | 19244 | 69 | 50585801 |
Anencephaly | 48.00 | 17.68 | 12 | 19242 | 202 | 50585668 |
Renal tubular acidosis | 47.77 | 17.68 | 19 | 19235 | 1515 | 50584355 |
Gastrointestinal disorder congenital | 47.69 | 17.68 | 11 | 19243 | 129 | 50585741 |
Portal hypertension | 47.46 | 17.68 | 24 | 19230 | 3368 | 50582502 |
Mitochondrial cytopathy | 46.89 | 17.68 | 12 | 19242 | 223 | 50585647 |
Congenital genital malformation | 46.86 | 17.68 | 11 | 19243 | 140 | 50585730 |
Acute kidney injury | 45.96 | 17.68 | 190 | 19064 | 227868 | 50358002 |
Peripheral swelling | 45.88 | 17.68 | 11 | 19243 | 205925 | 50379945 |
CSF HIV escape syndrome | 45.76 | 17.68 | 10 | 19244 | 90 | 50585780 |
Foetal malnutrition | 45.66 | 17.68 | 10 | 19244 | 91 | 50585779 |
Neonatal respiratory arrest | 45.60 | 17.68 | 9 | 19245 | 46 | 50585824 |
Exomphalos | 44.98 | 17.68 | 14 | 19240 | 539 | 50585331 |
Dyspnoea | 44.89 | 17.68 | 88 | 19166 | 547520 | 50038350 |
Gastrointestinal malformation | 44.64 | 17.68 | 11 | 19243 | 174 | 50585696 |
Arthralgia | 43.80 | 17.68 | 62 | 19192 | 438640 | 50147230 |
Ultrasound antenatal screen abnormal | 43.53 | 17.68 | 10 | 19244 | 115 | 50585755 |
Sudden infant death syndrome | 43.15 | 17.68 | 11 | 19243 | 201 | 50585669 |
Skin striae | 42.92 | 17.68 | 16 | 19238 | 1070 | 50584800 |
Lactic acidosis | 42.88 | 17.68 | 58 | 19196 | 33297 | 50552573 |
Hydrocephalus | 42.31 | 17.68 | 25 | 19229 | 4763 | 50581107 |
Ichthyosis | 42.13 | 17.68 | 8 | 19246 | 32 | 50585838 |
Placental disorder | 42.06 | 17.68 | 17 | 19237 | 1413 | 50584457 |
Single umbilical artery | 41.53 | 17.68 | 11 | 19243 | 235 | 50585635 |
Adrenal insufficiency | 41.46 | 17.68 | 38 | 19216 | 14205 | 50571665 |
Hepatic cytolysis | 41.36 | 17.68 | 30 | 19224 | 8073 | 50577797 |
Anembryonic gestation | 41.27 | 17.68 | 13 | 19241 | 521 | 50585349 |
Alopecia | 41.07 | 17.68 | 21 | 19233 | 245026 | 50340844 |
Foetal heart rate disorder | 40.89 | 17.68 | 9 | 19245 | 84 | 50585786 |
Double outlet right ventricle | 40.85 | 17.68 | 8 | 19246 | 39 | 50585831 |
Meningomyelocele | 40.41 | 17.68 | 13 | 19241 | 558 | 50585312 |
Coarctation of the aorta | 40.37 | 17.68 | 13 | 19241 | 560 | 50585310 |
Therapeutic product effect decreased | 40.28 | 17.68 | 3 | 19251 | 136047 | 50449823 |
Cholestasis | 40.25 | 17.68 | 49 | 19205 | 25352 | 50560518 |
Ectopic pregnancy | 40.15 | 17.68 | 19 | 19235 | 2308 | 50583562 |
Congenital ectopic bladder | 39.63 | 17.68 | 9 | 19245 | 98 | 50585772 |
Systemic lupus erythematosus | 39.19 | 17.68 | 4 | 19250 | 140618 | 50445252 |
CSF test abnormal | 38.80 | 17.68 | 11 | 19243 | 305 | 50585565 |
Anaemia | 38.68 | 17.68 | 194 | 19060 | 252262 | 50333608 |
Abdominal discomfort | 38.59 | 17.68 | 20 | 19234 | 231621 | 50354249 |
Hyperadrenocorticism | 38.50 | 17.68 | 11 | 19243 | 314 | 50585556 |
Hemivertebra | 37.96 | 17.68 | 9 | 19245 | 120 | 50585750 |
Constipation | 37.47 | 17.68 | 12 | 19242 | 185696 | 50400174 |
Mitochondrial toxicity | 37.45 | 17.68 | 11 | 19243 | 347 | 50585523 |
Cough | 37.09 | 17.68 | 23 | 19231 | 241241 | 50344629 |
Placental insufficiency | 36.89 | 17.68 | 15 | 19239 | 1266 | 50584604 |
Central obesity | 36.56 | 17.68 | 14 | 19240 | 1008 | 50584862 |
Oesophageal candidiasis | 36.26 | 17.68 | 23 | 19231 | 4971 | 50580899 |
Pregnancy on contraceptive | 36.17 | 17.68 | 14 | 19240 | 1038 | 50584832 |
Hepatotoxicity | 36.00 | 17.68 | 48 | 19206 | 27178 | 50558692 |
Oligohydramnios | 35.69 | 17.68 | 24 | 19230 | 5726 | 50580144 |
Jaundice | 35.57 | 17.68 | 47 | 19207 | 26382 | 50559488 |
Small for dates baby | 35.50 | 17.68 | 20 | 19234 | 3485 | 50582385 |
Pain in extremity | 35.49 | 17.68 | 31 | 19223 | 272834 | 50313036 |
Sepsis neonatal | 35.46 | 17.68 | 11 | 19243 | 419 | 50585451 |
Infection | 35.21 | 17.68 | 11 | 19243 | 172943 | 50412927 |
Genotype drug resistance test positive | 35.18 | 17.68 | 10 | 19244 | 280 | 50585590 |
Osteoporosis | 33.79 | 17.68 | 61 | 19193 | 44818 | 50541052 |
Nephropathy toxic | 32.74 | 17.68 | 26 | 19228 | 8003 | 50577867 |
Endometritis decidual | 32.69 | 17.68 | 6 | 19248 | 19 | 50585851 |
Threatened labour | 32.59 | 17.68 | 12 | 19242 | 775 | 50585095 |
Pneumonia | 32.53 | 17.68 | 59 | 19195 | 378342 | 50207528 |
Rash maculo-papular | 32.24 | 17.68 | 45 | 19209 | 26596 | 50559274 |
Microcephaly | 32.17 | 17.68 | 12 | 19242 | 804 | 50585066 |
Drug hypersensitivity | 32.05 | 17.68 | 29 | 19225 | 250981 | 50334889 |
Muscle spasms | 31.53 | 17.68 | 5 | 19249 | 125548 | 50460322 |
Left ventricular dilatation | 31.34 | 17.68 | 10 | 19244 | 418 | 50585452 |
Transaminases increased | 30.74 | 17.68 | 45 | 19209 | 27779 | 50558091 |
Discomfort | 30.41 | 17.68 | 3 | 19251 | 108377 | 50477493 |
Pulmonary valve sclerosis | 30.35 | 17.68 | 6 | 19248 | 31 | 50585839 |
Cerebral toxoplasmosis | 30.22 | 17.68 | 11 | 19243 | 688 | 50585182 |
Lipoatrophy | 30.05 | 17.68 | 9 | 19245 | 304 | 50585566 |
Congenital central nervous system anomaly | 29.50 | 17.68 | 9 | 19245 | 324 | 50585546 |
Abortion threatened | 29.01 | 17.68 | 10 | 19244 | 533 | 50585337 |
Condition aggravated | 28.60 | 17.68 | 43 | 19211 | 297015 | 50288855 |
Renal tubular dysfunction | 28.49 | 17.68 | 9 | 19245 | 364 | 50585506 |
Urinary tract infection | 28.46 | 17.68 | 26 | 19228 | 223994 | 50361876 |
Cachexia | 28.32 | 17.68 | 19 | 19235 | 4514 | 50581356 |
Potassium wasting nephropathy | 28.31 | 17.68 | 6 | 19248 | 46 | 50585824 |
Congenital skin dimples | 28.16 | 17.68 | 7 | 19247 | 115 | 50585755 |
Atrial fibrillation | 28.07 | 17.68 | 3 | 19251 | 101742 | 50484128 |
Cardiac murmur | 27.99 | 17.68 | 27 | 19227 | 10757 | 50575113 |
Congenital eye disorder | 27.97 | 17.68 | 5 | 19249 | 13 | 50585857 |
Contraindicated product administered | 27.70 | 17.68 | 11 | 19243 | 148947 | 50436923 |
HIV-associated neurocognitive disorder | 27.67 | 17.68 | 7 | 19247 | 124 | 50585746 |
Product dose omission issue | 27.58 | 17.68 | 18 | 19236 | 183820 | 50402050 |
Hypophosphataemia | 27.56 | 17.68 | 24 | 19230 | 8390 | 50577480 |
Total bile acids increased | 27.51 | 17.68 | 7 | 19247 | 127 | 50585743 |
Cardiac malposition | 27.45 | 17.68 | 6 | 19248 | 54 | 50585816 |
Renal tubular necrosis | 27.42 | 17.68 | 26 | 19228 | 10142 | 50575728 |
Headache | 27.34 | 17.68 | 100 | 19154 | 506435 | 50079435 |
Bronchitis | 26.49 | 17.68 | 4 | 19250 | 104155 | 50481715 |
Hypoaesthesia | 26.06 | 17.68 | 8 | 19246 | 127249 | 50458621 |
Osteonecrosis | 25.72 | 17.68 | 37 | 19217 | 22480 | 50563390 |
Blood bilirubin unconjugated increased | 25.68 | 17.68 | 8 | 19246 | 309 | 50585561 |
Oesophageal atresia | 25.44 | 17.68 | 9 | 19245 | 518 | 50585352 |
Mental disability | 25.17 | 17.68 | 6 | 19248 | 82 | 50585788 |
Hepatic displacement | 25.10 | 17.68 | 5 | 19249 | 27 | 50585843 |
Hyperlactacidaemia | 24.96 | 17.68 | 14 | 19240 | 2419 | 50583451 |
Drug intolerance | 24.90 | 17.68 | 28 | 19226 | 219076 | 50366794 |
Placental chorioangioma | 24.73 | 17.68 | 4 | 19250 | 4 | 50585866 |
Musculoskeletal stiffness | 24.70 | 17.68 | 9 | 19245 | 128472 | 50457398 |
Nephrolithiasis | 24.66 | 17.68 | 46 | 19208 | 34647 | 50551223 |
Foetal anaemia | 24.66 | 17.68 | 5 | 19249 | 30 | 50585840 |
Breast disorder | 24.53 | 17.68 | 13 | 19241 | 2009 | 50583861 |
Isoimmune haemolytic disease | 24.51 | 17.68 | 5 | 19249 | 31 | 50585839 |
Therapeutic product effect incomplete | 24.49 | 17.68 | 3 | 19251 | 91512 | 50494358 |
Atrioventricular block complete | 24.38 | 17.68 | 21 | 19233 | 7234 | 50578636 |
Death neonatal | 23.70 | 17.68 | 7 | 19247 | 225 | 50585645 |
Gestational hypertension | 23.65 | 17.68 | 13 | 19241 | 2160 | 50583710 |
Conduction disorder | 23.55 | 17.68 | 11 | 19243 | 1297 | 50584573 |
Maxillonasal dysplasia | 23.46 | 17.68 | 4 | 19250 | 7 | 50585863 |
Encephalomalacia | 22.94 | 17.68 | 8 | 19246 | 441 | 50585429 |
Subchorionic haematoma | 22.89 | 17.68 | 6 | 19248 | 123 | 50585747 |
Arthritis | 22.83 | 17.68 | 3 | 19251 | 86718 | 50499152 |
Glucocorticoids increased | 22.75 | 17.68 | 6 | 19248 | 126 | 50585744 |
Nodular regenerative hyperplasia | 22.60 | 17.68 | 7 | 19247 | 265 | 50585605 |
Amniotic fluid volume decreased | 22.54 | 17.68 | 8 | 19246 | 465 | 50585405 |
Congenital pulmonary valve disorder | 22.49 | 17.68 | 5 | 19249 | 49 | 50585821 |
Bovine tuberculosis | 22.23 | 17.68 | 5 | 19249 | 52 | 50585818 |
Off label use | 22.22 | 17.68 | 99 | 19155 | 474327 | 50111543 |
Complication of delivery | 22.03 | 17.68 | 6 | 19248 | 143 | 50585727 |
Congenital hand malformation | 22.00 | 17.68 | 7 | 19247 | 290 | 50585580 |
Alpha 1 foetoprotein abnormal | 21.97 | 17.68 | 5 | 19249 | 55 | 50585815 |
Immunosuppressant drug level increased | 21.89 | 17.68 | 14 | 19240 | 3068 | 50582802 |
Retroplacental haematoma | 21.87 | 17.68 | 6 | 19248 | 147 | 50585723 |
Prurigo | 21.84 | 17.68 | 9 | 19245 | 786 | 50585084 |
Epilepsy congenital | 21.72 | 17.68 | 4 | 19250 | 13 | 50585857 |
Dermatitis exfoliative generalised | 21.71 | 17.68 | 14 | 19240 | 3112 | 50582758 |
Foetal malformation | 21.35 | 17.68 | 6 | 19248 | 161 | 50585709 |
Transposition of the great vessels | 21.25 | 17.68 | 6 | 19248 | 164 | 50585706 |
Back pain | 21.01 | 17.68 | 32 | 19222 | 219998 | 50365872 |
Portal vein thrombosis | 20.73 | 17.68 | 12 | 19242 | 2200 | 50583670 |
Feeling abnormal | 20.63 | 17.68 | 11 | 19243 | 125481 | 50460389 |
Psychomotor retardation | 20.57 | 17.68 | 14 | 19240 | 3404 | 50582466 |
Brachycephaly | 20.51 | 17.68 | 4 | 19250 | 19 | 50585851 |
Mobility decreased | 20.49 | 17.68 | 3 | 19251 | 79945 | 50505925 |
Coma hepatic | 20.48 | 17.68 | 8 | 19246 | 608 | 50585262 |
Dizziness | 20.26 | 17.68 | 66 | 19188 | 346303 | 50239567 |
Acquired immunodeficiency syndrome | 20.18 | 17.68 | 5 | 19249 | 81 | 50585789 |
Generalised anxiety disorder | 20.12 | 17.68 | 11 | 19243 | 1809 | 50584061 |
Pericarditis | 20.06 | 17.68 | 3 | 19251 | 78686 | 50507184 |
Diaphragmatic aplasia | 19.87 | 17.68 | 4 | 19250 | 23 | 50585847 |
Toxoplasmosis | 19.75 | 17.68 | 10 | 19244 | 1407 | 50584463 |
Cortisol decreased | 19.74 | 17.68 | 9 | 19245 | 1005 | 50584865 |
Hemiataxia | 19.72 | 17.68 | 4 | 19250 | 24 | 50585846 |
Thymus hypoplasia | 19.72 | 17.68 | 4 | 19250 | 24 | 50585846 |
Aqueductal stenosis | 19.72 | 17.68 | 4 | 19250 | 24 | 50585846 |
High arched palate | 19.43 | 17.68 | 5 | 19249 | 95 | 50585775 |
Clinodactyly | 19.38 | 17.68 | 5 | 19249 | 96 | 50585774 |
Congenital absence of bile ducts | 19.32 | 17.68 | 4 | 19250 | 27 | 50585843 |
Congenital genital malformation female | 19.32 | 17.68 | 4 | 19250 | 27 | 50585843 |
Glycosuria | 19.08 | 17.68 | 9 | 19245 | 1085 | 50584785 |
Pulmonary artery stenosis congenital | 19.06 | 17.68 | 6 | 19248 | 240 | 50585630 |
HIV test positive | 18.95 | 17.68 | 4 | 19250 | 30 | 50585840 |
Atrioventricular block first degree | 18.94 | 17.68 | 17 | 19237 | 6184 | 50579686 |
Cleft lip | 18.82 | 17.68 | 5 | 19249 | 108 | 50585762 |
Epidural lipomatosis | 18.82 | 17.68 | 5 | 19249 | 108 | 50585762 |
Ultrasound scan abnormal | 18.62 | 17.68 | 6 | 19248 | 259 | 50585611 |
Proteinuria | 18.56 | 17.68 | 27 | 19227 | 16570 | 50569300 |
Brain stem auditory evoked response abnormal | 18.55 | 17.68 | 3 | 19251 | 3 | 50585867 |
Skeletal dysplasia | 18.55 | 17.68 | 3 | 19251 | 3 | 50585867 |
Jaundice neonatal | 18.35 | 17.68 | 8 | 19246 | 803 | 50585067 |
Developmental coordination disorder | 18.11 | 17.68 | 4 | 19250 | 38 | 50585832 |
Hepatitis C | 18.10 | 17.68 | 15 | 19239 | 4902 | 50580968 |
Stomatitis | 18.00 | 17.68 | 8 | 19246 | 101336 | 50484534 |
Foetal arrhythmia | 17.98 | 17.68 | 5 | 19249 | 129 | 50585741 |
Hepatitis | 17.89 | 17.68 | 38 | 19216 | 31415 | 50554455 |
Coagulation factor V level decreased | 17.89 | 17.68 | 6 | 19248 | 294 | 50585576 |
Congenital cystic lung | 17.75 | 17.68 | 4 | 19250 | 42 | 50585828 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Foetal exposure during pregnancy | 976.27 | 12.71 | 558 | 33075 | 33309 | 29507585 |
Drug interaction | 631.14 | 12.71 | 935 | 32698 | 196450 | 29344444 |
Immune reconstitution inflammatory syndrome | 597.71 | 12.71 | 251 | 33382 | 7551 | 29533343 |
Lipodystrophy acquired | 504.82 | 12.71 | 173 | 33460 | 2921 | 29537973 |
Virologic failure | 306.15 | 12.71 | 117 | 33516 | 2730 | 29538164 |
Progressive external ophthalmoplegia | 284.35 | 12.71 | 91 | 33542 | 1226 | 29539668 |
Mitochondrial toxicity | 284.31 | 12.71 | 106 | 33527 | 2305 | 29538589 |
Premature baby | 279.53 | 12.71 | 198 | 33435 | 17082 | 29523812 |
Renal tubular disorder | 274.14 | 12.71 | 122 | 33511 | 4230 | 29536664 |
Fanconi syndrome acquired | 254.41 | 12.71 | 91 | 33542 | 1751 | 29539143 |
Osteoporosis | 248.43 | 12.71 | 154 | 33479 | 10615 | 29530279 |
Exposure during pregnancy | 211.80 | 12.71 | 128 | 33505 | 8426 | 29532468 |
Eyelid ptosis | 197.64 | 12.71 | 103 | 33530 | 5083 | 29535811 |
Viral load increased | 194.75 | 12.71 | 77 | 33556 | 1972 | 29538922 |
CD4 lymphocytes decreased | 180.19 | 12.71 | 68 | 33565 | 1530 | 29539364 |
Trisomy 21 | 178.22 | 12.71 | 51 | 33582 | 456 | 29540438 |
Osteonecrosis | 169.55 | 12.71 | 133 | 33500 | 13386 | 29527508 |
Hyperbilirubinaemia | 168.31 | 12.71 | 138 | 33495 | 14796 | 29526098 |
Blood HIV RNA increased | 150.56 | 12.71 | 53 | 33580 | 971 | 29539923 |
Hypertriglyceridaemia | 147.77 | 12.71 | 97 | 33536 | 7378 | 29533516 |
Adrenal suppression | 145.25 | 12.71 | 44 | 33589 | 488 | 29540406 |
Nephrolithiasis | 139.95 | 12.71 | 158 | 33475 | 25176 | 29515718 |
Syphilis | 136.09 | 12.71 | 38 | 33595 | 308 | 29540586 |
Cushing's syndrome | 134.98 | 12.71 | 39 | 33594 | 362 | 29540532 |
Kaposi's sarcoma | 128.21 | 12.71 | 45 | 33588 | 817 | 29540077 |
Polydactyly | 123.08 | 12.71 | 47 | 33586 | 1093 | 29539801 |
HIV-associated neurocognitive disorder | 116.22 | 12.71 | 33 | 33600 | 286 | 29540608 |
Lipoatrophy | 102.32 | 12.71 | 33 | 33600 | 456 | 29540438 |
Psychiatric decompensation | 97.39 | 12.71 | 43 | 33590 | 1461 | 29539433 |
Diplopia | 97.16 | 12.71 | 97 | 33536 | 13421 | 29527473 |
Drug resistance | 95.31 | 12.71 | 120 | 33513 | 21420 | 29519474 |
Glycosuria | 94.35 | 12.71 | 39 | 33594 | 1123 | 29539771 |
Viral mutation identified | 93.60 | 12.71 | 49 | 33584 | 2439 | 29538455 |
Jaundice | 93.03 | 12.71 | 139 | 33494 | 29157 | 29511737 |
Fanconi syndrome | 88.61 | 12.71 | 41 | 33592 | 1557 | 29539337 |
Depression suicidal | 86.45 | 12.71 | 38 | 33595 | 1277 | 29539617 |
Mycobacterium avium complex infection | 86.25 | 12.71 | 45 | 33588 | 2224 | 29538670 |
Hyperlipidaemia | 86.19 | 12.71 | 88 | 33545 | 12502 | 29528392 |
Nephropathy toxic | 82.54 | 12.71 | 80 | 33553 | 10676 | 29530218 |
Retinal toxicity | 79.40 | 12.71 | 26 | 33607 | 378 | 29540516 |
Tearfulness | 78.52 | 12.71 | 38 | 33595 | 1598 | 29539296 |
Dyslipidaemia | 76.77 | 12.71 | 60 | 33573 | 6001 | 29534893 |
Heterotaxia | 74.31 | 12.71 | 19 | 33614 | 105 | 29540789 |
Low birth weight baby | 74.29 | 12.71 | 61 | 33572 | 6547 | 29534347 |
Congenital anomaly | 73.41 | 12.71 | 34 | 33599 | 1294 | 29539600 |
Proteinuria | 73.04 | 12.71 | 90 | 33543 | 15714 | 29525180 |
Hypophosphataemia | 72.49 | 12.71 | 65 | 33568 | 7859 | 29533035 |
Hepatitis C | 71.64 | 12.71 | 68 | 33565 | 8842 | 29532052 |
Ventricular septal defect | 67.81 | 12.71 | 45 | 33588 | 3484 | 29537410 |
Laryngomalacia | 64.99 | 12.71 | 21 | 33612 | 292 | 29540602 |
Cortisol decreased | 64.47 | 12.71 | 27 | 33606 | 804 | 29540090 |
Atrial fibrillation | 64.43 | 12.71 | 20 | 33613 | 105626 | 29435268 |
Fall | 64.38 | 12.71 | 64 | 33569 | 177114 | 29363780 |
Renal colic | 64.37 | 12.71 | 33 | 33600 | 1572 | 29539322 |
Dyspnoea | 63.88 | 12.71 | 177 | 33456 | 326555 | 29214339 |
Hyperlactacidaemia | 63.51 | 12.71 | 39 | 33594 | 2639 | 29538255 |
Blood triglycerides increased | 62.41 | 12.71 | 75 | 33558 | 12759 | 29528135 |
Acquired immunodeficiency syndrome | 62.39 | 12.71 | 22 | 33611 | 405 | 29540489 |
Pyelocaliectasis | 60.08 | 12.71 | 28 | 33605 | 1081 | 29539813 |
Anal cancer | 57.97 | 12.71 | 20 | 33613 | 344 | 29540550 |
Oesophageal candidiasis | 57.65 | 12.71 | 42 | 33591 | 3779 | 29537115 |
Ophthalmoplegia | 57.27 | 12.71 | 31 | 33602 | 1651 | 29539243 |
Cushingoid | 56.53 | 12.71 | 35 | 33598 | 2403 | 29538491 |
Calculus urinary | 56.04 | 12.71 | 27 | 33606 | 1124 | 29539770 |
Genotype drug resistance test positive | 55.95 | 12.71 | 26 | 33607 | 997 | 29539897 |
Drug ineffective | 55.64 | 12.71 | 219 | 33414 | 362951 | 29177943 |
Disease progression | 54.65 | 12.71 | 13 | 33620 | 81903 | 29458991 |
Hypotension | 54.12 | 12.71 | 86 | 33547 | 194268 | 29346626 |
Adrenal insufficiency | 52.49 | 12.71 | 64 | 33569 | 11050 | 29529844 |
Renal impairment | 51.64 | 12.71 | 206 | 33427 | 81127 | 29459767 |
Cerebral toxoplasmosis | 50.74 | 12.71 | 27 | 33606 | 1389 | 29539505 |
Blood bilirubin increased | 50.44 | 12.71 | 116 | 33517 | 33777 | 29507117 |
Drug level increased | 49.71 | 12.71 | 82 | 33551 | 18705 | 29522189 |
Portal hypertension | 49.62 | 12.71 | 37 | 33596 | 3449 | 29537445 |
Foetal growth restriction | 49.25 | 12.71 | 38 | 33595 | 3728 | 29537166 |
Febrile neutropenia | 48.80 | 12.71 | 34 | 33599 | 112206 | 29428688 |
Malignant neoplasm progression | 48.72 | 12.71 | 12 | 33621 | 73847 | 29467047 |
Blood pressure increased | 48.67 | 12.71 | 12 | 33621 | 73791 | 29467103 |
Atypical mycobacterial infection | 48.50 | 12.71 | 21 | 33612 | 680 | 29540214 |
Ventricular hypoplasia | 47.13 | 12.71 | 12 | 33621 | 65 | 29540829 |
Single umbilical artery | 46.86 | 12.71 | 15 | 33618 | 202 | 29540692 |
Completed suicide | 46.85 | 12.71 | 22 | 33611 | 90224 | 29450670 |
Blood bilirubin unconjugated increased | 46.19 | 12.71 | 19 | 33614 | 540 | 29540354 |
Depressive symptom | 45.88 | 12.71 | 27 | 33606 | 1690 | 29539204 |
Progressive multifocal leukoencephalopathy | 45.78 | 12.71 | 53 | 33580 | 8666 | 29532228 |
Congenital hydronephrosis | 45.20 | 12.71 | 20 | 33613 | 683 | 29540211 |
Pneumonia | 44.69 | 12.71 | 200 | 33433 | 319972 | 29220922 |
Ergot poisoning | 43.98 | 12.71 | 10 | 33623 | 30 | 29540864 |
Pathogen resistance | 43.73 | 12.71 | 50 | 33583 | 8066 | 29532828 |
Chordee | 43.61 | 12.71 | 11 | 33622 | 57 | 29540837 |
Cytomegalovirus chorioretinitis | 43.06 | 12.71 | 33 | 33600 | 3205 | 29537689 |
Death | 42.91 | 12.71 | 222 | 33411 | 341862 | 29199032 |
Genital herpes | 42.76 | 12.71 | 18 | 33615 | 543 | 29540351 |
Cardiac failure congestive | 42.39 | 12.71 | 17 | 33616 | 76564 | 29464330 |
Oesophageal atresia | 42.25 | 12.71 | 17 | 33616 | 456 | 29540438 |
Renal tubular acidosis | 42.10 | 12.71 | 26 | 33607 | 1777 | 29539117 |
Mitochondrial cytopathy | 41.10 | 12.71 | 13 | 33620 | 168 | 29540726 |
Hyperadrenocorticism | 41.05 | 12.71 | 11 | 33622 | 75 | 29540819 |
Hepatic cirrhosis | 40.87 | 12.71 | 65 | 33568 | 14379 | 29526515 |
Hypospadias | 40.82 | 12.71 | 31 | 33602 | 2971 | 29537923 |
Peripheral swelling | 40.80 | 12.71 | 11 | 33622 | 63728 | 29477166 |
Anogenital dysplasia | 40.73 | 12.71 | 12 | 33621 | 120 | 29540774 |
Drug abuse | 40.65 | 12.71 | 20 | 33613 | 79863 | 29461031 |
Anogenital warts | 39.33 | 12.71 | 17 | 33616 | 548 | 29540346 |
Lipohypertrophy | 38.73 | 12.71 | 13 | 33620 | 205 | 29540689 |
Constipation | 38.33 | 12.71 | 44 | 33589 | 114116 | 29426778 |
Hypercholesterolaemia | 38.01 | 12.71 | 44 | 33589 | 7194 | 29533700 |
Atrioventricular septal defect | 37.95 | 12.71 | 12 | 33621 | 155 | 29540739 |
Maternal drugs affecting foetus | 37.73 | 12.71 | 33 | 33600 | 3860 | 29537034 |
Psychomotor skills impaired | 37.33 | 12.71 | 28 | 33605 | 2633 | 29538261 |
Blood lactic acid increased | 37.11 | 12.71 | 39 | 33594 | 5727 | 29535167 |
CSF HIV escape syndrome | 36.67 | 12.71 | 12 | 33621 | 174 | 29540720 |
Vanishing bile duct syndrome | 35.47 | 12.71 | 16 | 33617 | 572 | 29540322 |
Paranoia | 34.43 | 12.71 | 49 | 33584 | 9828 | 29531066 |
Blood phosphorus decreased | 34.04 | 12.71 | 27 | 33606 | 2758 | 29538136 |
Cachexia | 34.02 | 12.71 | 39 | 33594 | 6310 | 29534584 |
Renal tubular dysfunction | 34.00 | 12.71 | 14 | 33619 | 399 | 29540495 |
Pneumocystis jirovecii pneumonia | 33.78 | 12.71 | 65 | 33568 | 16714 | 29524180 |
Fibrous histiocytoma | 33.76 | 12.71 | 10 | 33623 | 102 | 29540792 |
Osteoporotic fracture | 33.01 | 12.71 | 18 | 33615 | 973 | 29539921 |
Hepatitis | 33.00 | 12.71 | 73 | 33560 | 20710 | 29520184 |
HIV infection | 32.69 | 12.71 | 19 | 33614 | 1162 | 29539732 |
Karyotype analysis abnormal | 32.65 | 12.71 | 8 | 33625 | 36 | 29540858 |
Porphyria non-acute | 32.51 | 12.71 | 14 | 33619 | 447 | 29540447 |
Genital herpes simplex | 32.37 | 12.71 | 10 | 33623 | 119 | 29540775 |
Gene mutation | 32.18 | 12.71 | 18 | 33615 | 1023 | 29539871 |
Hepatomegaly | 32.15 | 12.71 | 46 | 33587 | 9271 | 29531623 |
Off label use | 31.88 | 12.71 | 206 | 33427 | 300594 | 29240300 |
Hepatitis B | 31.55 | 12.71 | 35 | 33598 | 5462 | 29535432 |
Hypothalamic pituitary adrenal axis suppression | 31.29 | 12.71 | 10 | 33623 | 134 | 29540760 |
Infusion related reaction | 31.23 | 12.71 | 6 | 33627 | 43880 | 29497014 |
HIV wasting syndrome | 31.10 | 12.71 | 9 | 33624 | 84 | 29540810 |
Secondary adrenocortical insufficiency | 31.09 | 12.71 | 18 | 33615 | 1093 | 29539801 |
Oropharyngeal candidiasis | 30.83 | 12.71 | 15 | 33618 | 638 | 29540256 |
Cryptorchism | 30.79 | 12.71 | 22 | 33611 | 1920 | 29538974 |
Toxoplasmosis | 30.26 | 12.71 | 18 | 33615 | 1149 | 29539745 |
Small for dates baby | 30.08 | 12.71 | 28 | 33605 | 3551 | 29537343 |
Castleman's disease | 30.07 | 12.71 | 7 | 33626 | 24 | 29540870 |
Treatment noncompliance | 29.72 | 12.71 | 77 | 33556 | 24150 | 29516744 |
Haemophilic arthropathy | 29.45 | 12.71 | 9 | 33624 | 103 | 29540791 |
Renal failure | 29.40 | 12.71 | 233 | 33400 | 118366 | 29422528 |
Hemivertebra | 29.37 | 12.71 | 9 | 33624 | 104 | 29540790 |
Mycobacterial infection | 29.36 | 12.71 | 21 | 33612 | 1835 | 29539059 |
Foetal chromosome abnormality | 29.20 | 12.71 | 6 | 33627 | 9 | 29540885 |
Ectopic kidney | 29.03 | 12.71 | 7 | 33626 | 29 | 29540865 |
Liver disorder | 28.86 | 12.71 | 83 | 33550 | 27666 | 29513228 |
Heart disease congenital | 28.73 | 12.71 | 18 | 33615 | 1262 | 29539632 |
Hydrocele | 28.40 | 12.71 | 21 | 33612 | 1932 | 29538962 |
Pain | 28.33 | 12.71 | 100 | 33533 | 171332 | 29369562 |
Congenital nystagmus | 28.10 | 12.71 | 6 | 33627 | 12 | 29540882 |
Multiple-drug resistance | 28.04 | 12.71 | 28 | 33605 | 3872 | 29537022 |
Neonatal hyponatraemia | 28.00 | 12.71 | 8 | 33625 | 71 | 29540823 |
Pulmonary malformation | 27.80 | 12.71 | 7 | 33626 | 36 | 29540858 |
Foetal death | 27.68 | 12.71 | 10 | 33623 | 198 | 29540696 |
Alanine aminotransferase increased | 27.63 | 12.71 | 156 | 33477 | 70788 | 29470106 |
Anal cancer stage 0 | 27.47 | 12.71 | 6 | 33627 | 14 | 29540880 |
Blood corticotrophin decreased | 27.41 | 12.71 | 9 | 33624 | 132 | 29540762 |
Psychotic disorder | 27.39 | 12.71 | 67 | 33566 | 20287 | 29520607 |
Hodgkin's disease | 27.07 | 12.71 | 15 | 33618 | 837 | 29540057 |
Haemorrhage | 26.63 | 12.71 | 9 | 33624 | 45063 | 29495831 |
Blood creatine phosphokinase increased | 26.61 | 12.71 | 104 | 33529 | 40540 | 29500354 |
Treponema test positive | 26.56 | 12.71 | 5 | 33628 | 3 | 29540891 |
Acute kidney injury | 26.52 | 12.71 | 436 | 33197 | 264831 | 29276063 |
Psychomotor retardation | 26.40 | 12.71 | 24 | 33609 | 2952 | 29537942 |
Inappropriate schedule of product administration | 26.06 | 12.71 | 9 | 33624 | 44463 | 29496431 |
Exomphalos | 26.02 | 12.71 | 9 | 33624 | 156 | 29540738 |
Intentional product use issue | 25.97 | 12.71 | 8 | 33625 | 42490 | 29498404 |
Blood antidiuretic hormone increased | 25.96 | 12.71 | 7 | 33626 | 49 | 29540845 |
Fat tissue increased | 25.91 | 12.71 | 11 | 33622 | 339 | 29540555 |
Sepsis | 25.79 | 12.71 | 80 | 33553 | 142602 | 29398292 |
Feeling abnormal | 25.68 | 12.71 | 15 | 33618 | 54430 | 29486464 |
Lactic acidosis | 25.43 | 12.71 | 84 | 33549 | 30163 | 29510731 |
Blood alkaline phosphatase increased | 24.89 | 12.71 | 80 | 33553 | 28326 | 29512568 |
Foetal distress syndrome | 24.85 | 12.71 | 15 | 33618 | 984 | 29539910 |
Burkitt's lymphoma | 24.71 | 12.71 | 8 | 33625 | 112 | 29540782 |
Malaria | 24.55 | 12.71 | 9 | 33624 | 186 | 29540708 |
Product use issue | 24.51 | 12.71 | 14 | 33619 | 51430 | 29489464 |
Joint swelling | 24.38 | 12.71 | 13 | 33620 | 49617 | 29491277 |
Hepatic failure | 24.29 | 12.71 | 85 | 33548 | 31427 | 29509467 |
Infection | 24.24 | 12.71 | 31 | 33602 | 76720 | 29464174 |
Pancreatitis | 23.98 | 12.71 | 90 | 33543 | 34424 | 29506470 |
CSF virus identified | 23.97 | 12.71 | 6 | 33627 | 30 | 29540864 |
Opportunistic infection | 23.91 | 12.71 | 17 | 33616 | 1472 | 29539422 |
Drug reaction with eosinophilia and systemic symptoms | 23.77 | 12.71 | 78 | 33555 | 27914 | 29512980 |
Superior mesenteric artery syndrome | 23.67 | 12.71 | 7 | 33626 | 71 | 29540823 |
Oral candidiasis | 23.40 | 12.71 | 43 | 33590 | 10679 | 29530215 |
Secondary syphilis | 23.34 | 12.71 | 6 | 33627 | 34 | 29540860 |
Dyschromatopsia | 23.29 | 12.71 | 10 | 33623 | 317 | 29540577 |
Beta 2 microglobulin urine increased | 23.16 | 12.71 | 7 | 33626 | 77 | 29540817 |
Therapeutic product effect incomplete | 22.96 | 12.71 | 8 | 33625 | 39297 | 29501597 |
Coarctation of the aorta | 22.83 | 12.71 | 11 | 33622 | 458 | 29540436 |
Chest discomfort | 22.65 | 12.71 | 12 | 33621 | 45971 | 29494923 |
Cholelithiasis | 22.55 | 12.71 | 59 | 33574 | 18613 | 29522281 |
Renal tubular necrosis | 22.40 | 12.71 | 50 | 33583 | 14265 | 29526629 |
Epistaxis | 22.00 | 12.71 | 16 | 33617 | 51688 | 29489206 |
Diaphragmatic hernia | 21.94 | 12.71 | 9 | 33624 | 254 | 29540640 |
Pneumonitis | 21.81 | 12.71 | 3 | 33630 | 28041 | 29512853 |
Drug level decreased | 21.79 | 12.71 | 31 | 33602 | 6216 | 29534678 |
Aspartate aminotransferase increased | 21.73 | 12.71 | 129 | 33504 | 59596 | 29481298 |
Acquired gene mutation | 21.68 | 12.71 | 15 | 33618 | 1243 | 29539651 |
Jarisch-Herxheimer reaction | 21.65 | 12.71 | 10 | 33623 | 378 | 29540516 |
Stillbirth | 21.62 | 12.71 | 8 | 33625 | 170 | 29540724 |
Lymphadenopathy | 21.45 | 12.71 | 70 | 33563 | 24979 | 29515915 |
Osteomalacia | 21.39 | 12.71 | 13 | 33620 | 863 | 29540031 |
International normalised ratio increased | 21.25 | 12.71 | 12 | 33621 | 44360 | 29496534 |
Kidney malformation | 21.19 | 12.71 | 8 | 33625 | 180 | 29540714 |
Hepatotoxicity | 21.11 | 12.71 | 56 | 33577 | 17811 | 29523083 |
Ocular icterus | 21.10 | 12.71 | 20 | 33613 | 2595 | 29538299 |
Gastroschisis | 21.05 | 12.71 | 7 | 33626 | 107 | 29540787 |
Neonatal asphyxia | 21.03 | 12.71 | 9 | 33624 | 283 | 29540611 |
Lymphogranuloma venereum | 20.89 | 12.71 | 4 | 33629 | 3 | 29540891 |
Interstitial lung disease | 20.74 | 12.71 | 21 | 33612 | 57697 | 29483197 |
Leishmaniasis | 20.71 | 12.71 | 9 | 33624 | 294 | 29540600 |
Blood cholesterol increased | 20.62 | 12.71 | 51 | 33582 | 15544 | 29525350 |
Cardiac murmur | 20.44 | 12.71 | 31 | 33602 | 6582 | 29534312 |
Depression | 20.38 | 12.71 | 166 | 33467 | 84981 | 29455913 |
Persistent left superior vena cava | 20.35 | 12.71 | 4 | 33629 | 4 | 29540890 |
Posterior cortical atrophy | 20.35 | 12.71 | 4 | 33629 | 4 | 29540890 |
Hepatic cytolysis | 20.17 | 12.71 | 35 | 33598 | 8312 | 29532582 |
Glucose urine present | 20.14 | 12.71 | 13 | 33620 | 960 | 29539934 |
CD4 lymphocytes increased | 19.97 | 12.71 | 8 | 33625 | 212 | 29540682 |
Intestinal malrotation | 19.97 | 12.71 | 5 | 33628 | 25 | 29540869 |
Congenital renal disorder | 19.85 | 12.71 | 6 | 33627 | 66 | 29540828 |
Suicidal ideation | 19.69 | 12.71 | 85 | 33548 | 34631 | 29506263 |
Hepatitis B DNA assay positive | 19.69 | 12.71 | 6 | 33627 | 68 | 29540826 |
Osteopenia | 19.67 | 12.71 | 24 | 33609 | 4144 | 29536750 |
Encephalitis | 19.67 | 12.71 | 30 | 33603 | 6400 | 29534494 |
Product dose omission issue | 19.64 | 12.71 | 51 | 33582 | 96332 | 29444562 |
Gamma-glutamyltransferase increased | 19.64 | 12.71 | 71 | 33562 | 26666 | 29514228 |
Central obesity | 19.63 | 12.71 | 10 | 33623 | 470 | 29540424 |
Gastrointestinal haemorrhage | 19.54 | 12.71 | 38 | 33595 | 79495 | 29461399 |
Urinary retention | 19.49 | 12.71 | 6 | 33627 | 31892 | 29509002 |
Hyperuricaemia | 19.48 | 12.71 | 31 | 33602 | 6858 | 29534036 |
Haematochezia | 19.20 | 12.71 | 9 | 33624 | 36974 | 29503920 |
Urinary tract infection | 19.17 | 12.71 | 33 | 33600 | 72321 | 29468573 |
Anomalous pulmonary venous connection | 19.15 | 12.71 | 6 | 33627 | 75 | 29540819 |
Chlamydial infection | 19.13 | 12.71 | 7 | 33626 | 144 | 29540750 |
Facial wasting | 19.13 | 12.71 | 7 | 33626 | 144 | 29540750 |
Cardio-respiratory arrest | 18.65 | 12.71 | 18 | 33615 | 50583 | 29490311 |
Vitamin D deficiency | 18.64 | 12.71 | 27 | 33606 | 5502 | 29535392 |
Tubulointerstitial nephritis | 18.56 | 12.71 | 53 | 33580 | 17590 | 29523304 |
Malignant anorectal neoplasm | 18.54 | 12.71 | 5 | 33628 | 35 | 29540859 |
Retinal deposits | 18.42 | 12.71 | 4 | 33629 | 9 | 29540885 |
Viral load decreased | 18.30 | 12.71 | 5 | 33628 | 37 | 29540857 |
Pulmonary sequestration | 18.30 | 12.71 | 5 | 33628 | 37 | 29540857 |
CD4 lymphocytes abnormal | 18.30 | 12.71 | 5 | 33628 | 37 | 29540857 |
Immune reconstitution inflammatory syndrome associated tuberculosis | 18.09 | 12.71 | 9 | 33624 | 402 | 29540492 |
Congenital coronary artery malformation | 17.64 | 12.71 | 5 | 33628 | 43 | 29540851 |
HIV associated nephropathy | 17.63 | 12.71 | 8 | 33625 | 290 | 29540604 |
Fontanelle bulging | 17.59 | 12.71 | 4 | 33629 | 12 | 29540882 |
Seborrhoeic dermatitis | 17.57 | 12.71 | 14 | 33619 | 1439 | 29539455 |
Retinal telangiectasia | 17.34 | 12.71 | 3 | 33630 | 0 | 29540894 |
Umbilical cord vascular disorder | 17.34 | 12.71 | 3 | 33630 | 0 | 29540894 |
Skin striae | 17.15 | 12.71 | 9 | 33624 | 450 | 29540444 |
Intentional product misuse | 17.14 | 12.71 | 9 | 33624 | 34652 | 29506242 |
Live birth | 16.95 | 12.71 | 7 | 33626 | 201 | 29540693 |
Depressed mood | 16.91 | 12.71 | 49 | 33584 | 16399 | 29524495 |
Injection site pain | 16.68 | 12.71 | 8 | 33625 | 32438 | 29508456 |
Amylase increased | 16.67 | 12.71 | 25 | 33608 | 5255 | 29535639 |
Neutrophil count decreased | 16.64 | 12.71 | 15 | 33618 | 43552 | 29497342 |
Heart rate increased | 16.63 | 12.71 | 12 | 33621 | 38926 | 29501968 |
Abdominal discomfort | 16.56 | 12.71 | 18 | 33615 | 47885 | 29493009 |
Cardiac disorder | 16.56 | 12.71 | 11 | 33622 | 37252 | 29503642 |
Psoriasis | 16.49 | 12.71 | 8 | 33625 | 32219 | 29508675 |
Adrenogenital syndrome | 16.38 | 12.71 | 5 | 33628 | 57 | 29540837 |
Fatigue | 16.29 | 12.71 | 258 | 33375 | 316563 | 29224331 |
Intentional overdose | 16.29 | 12.71 | 12 | 33621 | 38516 | 29502378 |
Nervous system disorder | 16.29 | 12.71 | 41 | 33592 | 12633 | 29528261 |
Pleural effusion | 16.27 | 12.71 | 36 | 33597 | 71872 | 29469022 |
Folate deficiency | 16.22 | 12.71 | 12 | 33621 | 1105 | 29539789 |
Cerebrovascular accident | 16.20 | 12.71 | 40 | 33593 | 76871 | 29464023 |
Product use in unapproved indication | 16.19 | 12.71 | 48 | 33585 | 86827 | 29454067 |
Hepatocellular injury | 16.11 | 12.71 | 57 | 33576 | 21186 | 29519708 |
Encephalitis viral | 16.08 | 12.71 | 12 | 33621 | 1120 | 29539774 |
AIDS related complication | 15.98 | 12.71 | 4 | 33629 | 20 | 29540874 |
Right aortic arch | 15.98 | 12.71 | 4 | 33629 | 20 | 29540874 |
Muscle injury | 15.88 | 12.71 | 12 | 33621 | 1141 | 29539753 |
Hypoglycaemia | 15.81 | 12.71 | 19 | 33614 | 48327 | 29492567 |
Atrial septal defect | 15.80 | 12.71 | 28 | 33605 | 6761 | 29534133 |
Hyperphosphaturia | 15.78 | 12.71 | 5 | 33628 | 65 | 29540829 |
Pancytopenia | 15.71 | 12.71 | 154 | 33479 | 83014 | 29457880 |
Central nervous system lymphoma | 15.67 | 12.71 | 10 | 33623 | 724 | 29540170 |
Acute stress disorder | 15.65 | 12.71 | 6 | 33627 | 141 | 29540753 |
Central pain syndrome | 15.64 | 12.71 | 5 | 33628 | 67 | 29540827 |
Nephrocalcinosis | 15.61 | 12.71 | 9 | 33624 | 542 | 29540352 |
Therapeutic product effect decreased | 15.55 | 12.71 | 7 | 33626 | 29444 | 29511450 |
Hepatic cancer | 15.51 | 12.71 | 27 | 33606 | 6429 | 29534465 |
Cardiac arrest | 15.44 | 12.71 | 48 | 33585 | 85543 | 29455351 |
Hepatosplenomegaly | 15.32 | 12.71 | 20 | 33613 | 3697 | 29537197 |
Eosinophilic pustular folliculitis | 15.31 | 12.71 | 5 | 33628 | 72 | 29540822 |
Ultrasound antenatal screen | 15.27 | 12.71 | 3 | 33630 | 3 | 29540891 |
ECG signs of ventricular hypertrophy | 15.27 | 12.71 | 3 | 33630 | 3 | 29540891 |
Foetal cystic hygroma | 15.27 | 12.71 | 3 | 33630 | 3 | 29540891 |
Immunoblastic lymphoma | 15.27 | 12.71 | 3 | 33630 | 3 | 29540891 |
Retroviral infection | 15.27 | 12.71 | 3 | 33630 | 3 | 29540891 |
17-hydroxyprogesterone increased | 15.27 | 12.71 | 3 | 33630 | 3 | 29540891 |
Polymicrogyria | 15.27 | 12.71 | 3 | 33630 | 3 | 29540891 |
Erythema elevatum diutinum | 15.23 | 12.71 | 4 | 33629 | 25 | 29540869 |
Arthropathy | 15.22 | 12.71 | 3 | 33630 | 21551 | 29519343 |
Congenital diaphragmatic hernia | 15.19 | 12.71 | 7 | 33626 | 263 | 29540631 |
Crystal urine | 15.19 | 12.71 | 5 | 33628 | 74 | 29540820 |
Hyperphagia | 15.11 | 12.71 | 12 | 33621 | 1228 | 29539666 |
Oral herpes | 15.09 | 12.71 | 22 | 33611 | 4510 | 29536384 |
Relapsing fever | 15.09 | 12.71 | 6 | 33627 | 156 | 29540738 |
Lymphoma | 15.01 | 12.71 | 34 | 33599 | 9794 | 29531100 |
Amyotrophy | 14.94 | 12.71 | 8 | 33625 | 417 | 29540477 |
Transaminases increased | 14.84 | 12.71 | 58 | 33575 | 22604 | 29518290 |
Post transplant distal limb syndrome | 14.76 | 12.71 | 7 | 33626 | 281 | 29540613 |
Anaemia neonatal | 14.74 | 12.71 | 7 | 33626 | 282 | 29540612 |
Blood pressure decreased | 14.74 | 12.71 | 18 | 33615 | 45459 | 29495435 |
Normal newborn | 14.67 | 12.71 | 6 | 33627 | 168 | 29540726 |
Lipids abnormal | 14.60 | 12.71 | 7 | 33626 | 288 | 29540606 |
Parotid gland enlargement | 14.56 | 12.71 | 7 | 33626 | 290 | 29540604 |
End stage AIDS | 14.48 | 12.71 | 4 | 33629 | 31 | 29540863 |
Dizziness | 14.42 | 12.71 | 142 | 33491 | 189542 | 29351352 |
Meconium ileus | 14.37 | 12.71 | 4 | 33629 | 32 | 29540862 |
Wrong dose | 14.31 | 12.71 | 8 | 33625 | 454 | 29540440 |
Congenital hydrocephalus | 14.28 | 12.71 | 5 | 33628 | 90 | 29540804 |
COVID-19 | 14.24 | 12.71 | 12 | 33621 | 36002 | 29504892 |
Testicular mass | 14.18 | 12.71 | 5 | 33628 | 92 | 29540802 |
Decreased appetite | 14.11 | 12.71 | 102 | 33531 | 145240 | 29395654 |
Blood HIV RNA | 14.05 | 12.71 | 3 | 33630 | 6 | 29540888 |
Congenital ureterocele | 14.05 | 12.71 | 3 | 33630 | 6 | 29540888 |
Trisomy 15 | 14.05 | 12.71 | 3 | 33630 | 6 | 29540888 |
Portal fibrosis | 14.04 | 12.71 | 7 | 33626 | 314 | 29540580 |
Spinal compression fracture | 14.01 | 12.71 | 25 | 33608 | 6069 | 29534825 |
Acute hepatitis C | 13.93 | 12.71 | 5 | 33628 | 97 | 29540797 |
Congenital hearing disorder | 13.93 | 12.71 | 5 | 33628 | 97 | 29540797 |
Blood creatinine increased | 13.90 | 12.71 | 153 | 33480 | 84949 | 29455945 |
Nephrogenic diabetes insipidus | 13.83 | 12.71 | 11 | 33622 | 1128 | 29539766 |
Chest pain | 13.77 | 12.71 | 73 | 33560 | 111900 | 29428994 |
Heart transplant rejection | 13.73 | 12.71 | 11 | 33622 | 1140 | 29539754 |
Neurosyphilis | 13.67 | 12.71 | 4 | 33629 | 39 | 29540855 |
Amoebic dysentery | 13.58 | 12.71 | 4 | 33629 | 40 | 29540854 |
Chronic hepatitis C | 13.56 | 12.71 | 7 | 33626 | 338 | 29540556 |
Kidney enlargement | 13.54 | 12.71 | 9 | 33624 | 698 | 29540196 |
Genitalia external ambiguous | 13.50 | 12.71 | 6 | 33627 | 207 | 29540687 |
Chronic obstructive pulmonary disease | 13.49 | 12.71 | 16 | 33617 | 40939 | 29499955 |
Congenital anaemia | 13.45 | 12.71 | 3 | 33630 | 8 | 29540886 |
Umbilical cord abnormality | 13.40 | 12.71 | 4 | 33629 | 42 | 29540852 |
Confusional state | 13.27 | 12.71 | 88 | 33545 | 127789 | 29413105 |
Congenital mitral valve incompetence | 13.27 | 12.71 | 5 | 33628 | 112 | 29540782 |
Enanthema | 13.27 | 12.71 | 7 | 33626 | 354 | 29540540 |
Intussusception | 13.26 | 12.71 | 8 | 33625 | 524 | 29540370 |
Radius fracture | 13.24 | 12.71 | 9 | 33624 | 725 | 29540169 |
Diabetes mellitus | 13.20 | 12.71 | 84 | 33549 | 39747 | 29501147 |
Hypo HDL cholesterolaemia | 13.19 | 12.71 | 3 | 33630 | 9 | 29540885 |
Oesophageal ulcer | 13.19 | 12.71 | 17 | 33616 | 3103 | 29537791 |
Non-Hodgkin's lymphoma | 13.14 | 12.71 | 12 | 33621 | 1485 | 29539409 |
Heart rate decreased | 13.03 | 12.71 | 6 | 33627 | 24906 | 29515988 |
Femoral neck fracture | 13.00 | 12.71 | 16 | 33617 | 2787 | 29538107 |
Neural tube defect | 12.99 | 12.71 | 4 | 33629 | 47 | 29540847 |
Foetal cardiac disorder | 12.95 | 12.71 | 3 | 33630 | 10 | 29540884 |
Duodenal atresia | 12.95 | 12.71 | 3 | 33630 | 10 | 29540884 |
Electric shock | 12.94 | 12.71 | 5 | 33628 | 120 | 29540774 |
Immunosuppressant drug level increased | 12.87 | 12.71 | 21 | 33612 | 4744 | 29536150 |
Retinitis pigmentosa | 12.84 | 12.71 | 4 | 33629 | 49 | 29540845 |
Ureterolithiasis | 12.84 | 12.71 | 13 | 33620 | 1827 | 29539067 |
Bulbar palsy | 12.84 | 12.71 | 6 | 33627 | 233 | 29540661 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Abortion spontaneous | 1249.29 | 13.33 | 496 | 38624 | 24647 | 64434965 |
Drug interaction | 1228.47 | 13.33 | 1290 | 37830 | 360793 | 64098819 |
Exposure during pregnancy | 939.50 | 13.33 | 585 | 38535 | 77090 | 64382522 |
Immune reconstitution inflammatory syndrome | 787.07 | 13.33 | 293 | 38827 | 12177 | 64447435 |
Lipodystrophy acquired | 662.02 | 13.33 | 195 | 38925 | 3832 | 64455780 |
Maternal exposure during pregnancy | 636.41 | 13.33 | 500 | 38620 | 95384 | 64364228 |
Virologic failure | 475.50 | 13.33 | 146 | 38974 | 3320 | 64456292 |
Abortion induced | 465.73 | 13.33 | 167 | 38953 | 6221 | 64453391 |
Stillbirth | 439.52 | 13.33 | 139 | 38981 | 3494 | 64456118 |
Live birth | 358.86 | 13.33 | 162 | 38958 | 11042 | 64448570 |
Mitochondrial toxicity | 358.56 | 13.33 | 111 | 39009 | 2595 | 64457017 |
Progressive external ophthalmoplegia | 344.89 | 13.33 | 92 | 39028 | 1235 | 64458377 |
Fanconi syndrome acquired | 340.67 | 13.33 | 104 | 39016 | 2317 | 64457295 |
Renal tubular disorder | 317.62 | 13.33 | 124 | 38996 | 5863 | 64453749 |
Hyperbilirubinaemia | 308.19 | 13.33 | 180 | 38940 | 21025 | 64438587 |
Adrenal suppression | 265.97 | 13.33 | 75 | 39045 | 1252 | 64458360 |
Premature delivery | 265.40 | 13.33 | 156 | 38964 | 18433 | 64441179 |
Viral load increased | 259.28 | 13.33 | 85 | 39035 | 2402 | 64457210 |
Caesarean section | 254.01 | 13.33 | 128 | 38992 | 11146 | 64448466 |
CD4 lymphocytes decreased | 252.96 | 13.33 | 83 | 39037 | 2352 | 64457260 |
Cushing's syndrome | 242.73 | 13.33 | 65 | 39055 | 886 | 64458726 |
Osteoporosis | 215.28 | 13.33 | 189 | 38931 | 41891 | 64417721 |
Foetal exposure during pregnancy | 210.54 | 13.33 | 85 | 39035 | 4391 | 64455221 |
Foetal death | 209.94 | 13.33 | 92 | 39028 | 5838 | 64453774 |
Blood HIV RNA increased | 201.36 | 13.33 | 62 | 39058 | 1422 | 64458190 |
Eyelid ptosis | 193.88 | 13.33 | 101 | 39019 | 9424 | 64450188 |
Viral mutation identified | 190.63 | 13.33 | 73 | 39047 | 3273 | 64456339 |
Pregnancy | 190.34 | 13.33 | 132 | 38988 | 20733 | 64438879 |
Drug resistance | 190.33 | 13.33 | 163 | 38957 | 34939 | 64424673 |
Premature rupture of membranes | 172.31 | 13.33 | 70 | 39050 | 3674 | 64455938 |
Osteonecrosis | 171.50 | 13.33 | 140 | 38980 | 28089 | 64431523 |
Nephrolithiasis | 161.70 | 13.33 | 164 | 38956 | 43519 | 64416093 |
Premature labour | 158.53 | 13.33 | 82 | 39038 | 7538 | 64452074 |
Syphilis | 142.72 | 13.33 | 37 | 39083 | 441 | 64459171 |
Hypertriglyceridaemia | 139.14 | 13.33 | 86 | 39034 | 11119 | 64448493 |
Nephropathy toxic | 134.94 | 13.33 | 100 | 39020 | 17414 | 64442198 |
Treatment noncompliance | 125.29 | 13.33 | 143 | 38977 | 43339 | 64416273 |
Jaundice | 123.94 | 13.33 | 150 | 38970 | 48362 | 64411250 |
Fanconi syndrome | 119.36 | 13.33 | 48 | 39072 | 2453 | 64457159 |
HIV-associated neurocognitive disorder | 115.87 | 13.33 | 29 | 39091 | 297 | 64459315 |
Renal colic | 111.76 | 13.33 | 45 | 39075 | 2307 | 64457305 |
Cushingoid | 111.64 | 13.33 | 65 | 39055 | 7538 | 64452074 |
Pathogen resistance | 111.22 | 13.33 | 78 | 39042 | 12465 | 64447147 |
CSF HIV escape syndrome | 110.98 | 13.33 | 28 | 39092 | 297 | 64459315 |
Psychiatric decompensation | 106.36 | 13.33 | 44 | 39076 | 2419 | 64457193 |
Lipoatrophy | 104.95 | 13.33 | 31 | 39089 | 614 | 64458998 |
Portal hypertension | 104.32 | 13.33 | 58 | 39062 | 6161 | 64453451 |
Pain | 101.41 | 13.33 | 112 | 39008 | 553399 | 63906213 |
Fall | 101.35 | 13.33 | 64 | 39056 | 416762 | 64042850 |
Mycobacterium avium complex infection | 98.42 | 13.33 | 48 | 39072 | 3892 | 64455720 |
Secondary adrenocortical insufficiency | 94.91 | 13.33 | 40 | 39080 | 2305 | 64457307 |
Ergot poisoning | 94.52 | 13.33 | 21 | 39099 | 121 | 64459491 |
Diplopia | 94.51 | 13.33 | 98 | 39022 | 26667 | 64432945 |
Acute kidney injury | 90.64 | 13.33 | 522 | 38598 | 448718 | 64010894 |
Dyslipidaemia | 90.26 | 13.33 | 61 | 39059 | 9181 | 64450431 |
Drug ineffective | 89.84 | 13.33 | 240 | 38880 | 840007 | 63619605 |
Placenta praevia | 89.49 | 13.33 | 28 | 39092 | 678 | 64458934 |
Premature baby | 88.20 | 13.33 | 42 | 39078 | 3230 | 64456382 |
Polyhydramnios | 86.71 | 13.33 | 33 | 39087 | 1454 | 64458158 |
Lipohypertrophy | 86.32 | 13.33 | 28 | 39092 | 764 | 64458848 |
Depression suicidal | 86.31 | 13.33 | 38 | 39082 | 2437 | 64457175 |
Glycosuria | 86.02 | 13.33 | 36 | 39084 | 2038 | 64457574 |
Proteinuria | 84.67 | 13.33 | 94 | 39026 | 27629 | 64431983 |
Adrenal insufficiency | 84.23 | 13.33 | 85 | 39035 | 22402 | 64437210 |
Joint swelling | 83.34 | 13.33 | 15 | 39105 | 215367 | 64244245 |
Hepatitis C | 82.85 | 13.33 | 62 | 39058 | 10953 | 64448659 |
Hypophosphataemia | 81.07 | 13.33 | 69 | 39051 | 14651 | 64444961 |
Peripheral swelling | 79.99 | 13.33 | 15 | 39105 | 209138 | 64250474 |
Infusion related reaction | 79.90 | 13.33 | 5 | 39115 | 164462 | 64295150 |
Renal tubular acidosis | 79.57 | 13.33 | 38 | 39082 | 2941 | 64456671 |
Cortisol decreased | 79.39 | 13.33 | 32 | 39088 | 1645 | 64457967 |
Retinal toxicity | 79.30 | 13.33 | 30 | 39090 | 1300 | 64458312 |
Hyperadrenocorticism | 77.83 | 13.33 | 21 | 39099 | 295 | 64459317 |
Calculus urinary | 76.24 | 13.33 | 32 | 39088 | 1825 | 64457787 |
Kaposi's sarcoma | 75.66 | 13.33 | 25 | 39095 | 724 | 64458888 |
Dyspnoea | 75.42 | 13.33 | 207 | 38913 | 718467 | 63741145 |
Pre-eclampsia | 75.27 | 13.33 | 47 | 39073 | 6184 | 64453428 |
Hyperlactacidaemia | 72.68 | 13.33 | 42 | 39078 | 4802 | 64454810 |
Blood bilirubin unconjugated increased | 70.70 | 13.33 | 25 | 39095 | 892 | 64458720 |
Gestational diabetes | 69.64 | 13.33 | 43 | 39077 | 5547 | 64454065 |
Renal tubular dysfunction | 69.25 | 13.33 | 23 | 39097 | 677 | 64458935 |
Tearfulness | 68.74 | 13.33 | 40 | 39080 | 4633 | 64454979 |
Blood bilirubin increased | 68.19 | 13.33 | 124 | 38996 | 57429 | 64402183 |
Genotype drug resistance test positive | 63.88 | 13.33 | 24 | 39096 | 1020 | 64458592 |
Cerebral toxoplasmosis | 63.56 | 13.33 | 28 | 39092 | 1798 | 64457814 |
Blood triglycerides increased | 62.89 | 13.33 | 67 | 39053 | 18799 | 64440813 |
Acquired immunodeficiency syndrome | 60.44 | 13.33 | 16 | 39104 | 208 | 64459404 |
Mitochondrial cytopathy | 60.08 | 13.33 | 18 | 39102 | 375 | 64459237 |
Normal newborn | 59.50 | 13.33 | 39 | 39081 | 5578 | 64454034 |
Hepatocellular injury | 59.45 | 13.33 | 102 | 39018 | 45133 | 64414479 |
Ophthalmoplegia | 58.87 | 13.33 | 30 | 39090 | 2672 | 64456940 |
Psychomotor retardation | 57.65 | 13.33 | 37 | 39083 | 5106 | 64454506 |
Renal failure | 57.22 | 13.33 | 240 | 38880 | 181448 | 64278164 |
Drug level increased | 57.11 | 13.33 | 86 | 39034 | 34110 | 64425502 |
Psychomotor skills impaired | 56.79 | 13.33 | 33 | 39087 | 3812 | 64455800 |
Lactic acidosis | 56.56 | 13.33 | 119 | 39001 | 61291 | 64398321 |
Central obesity | 56.16 | 13.33 | 24 | 39096 | 1431 | 64458181 |
Cholestasis of pregnancy | 55.64 | 13.33 | 21 | 39099 | 904 | 64458708 |
Multiple-drug resistance | 54.33 | 13.33 | 39 | 39081 | 6463 | 64453149 |
Swelling | 54.24 | 13.33 | 15 | 39105 | 160203 | 64299409 |
Completed suicide | 53.71 | 13.33 | 35 | 39085 | 224379 | 64235233 |
Renal impairment | 53.65 | 13.33 | 192 | 38928 | 134825 | 64324787 |
Skin striae | 53.26 | 13.33 | 23 | 39097 | 1407 | 64458205 |
Retinoblastoma | 52.25 | 13.33 | 12 | 39108 | 82 | 64459530 |
Amniotic cavity infection | 51.79 | 13.33 | 19 | 39101 | 755 | 64458857 |
Premature separation of placenta | 51.31 | 13.33 | 21 | 39099 | 1123 | 64458489 |
Oesophageal candidiasis | 51.29 | 13.33 | 41 | 39079 | 7976 | 64451636 |
Hepatotoxicity | 51.06 | 13.33 | 89 | 39031 | 39873 | 64419739 |
Atrial fibrillation | 50.93 | 13.33 | 20 | 39100 | 171069 | 64288543 |
Nasopharyngitis | 49.10 | 13.33 | 29 | 39091 | 196044 | 64263568 |
Blood pressure increased | 48.43 | 13.33 | 22 | 39098 | 172530 | 64287082 |
Pneumocystis jirovecii pneumonia | 48.30 | 13.33 | 71 | 39049 | 27563 | 64432049 |
Synovitis | 48.15 | 13.33 | 3 | 39117 | 99087 | 64360525 |
Renal tubular necrosis | 47.91 | 13.33 | 63 | 39057 | 22047 | 64437565 |
Constipation | 45.74 | 13.33 | 43 | 39077 | 229294 | 64230318 |
Arthralgia | 45.05 | 13.33 | 129 | 38991 | 442131 | 64017481 |
Therapeutic product effect decreased | 44.66 | 13.33 | 8 | 39112 | 115343 | 64344269 |
Toxoplasmosis | 44.32 | 13.33 | 24 | 39096 | 2420 | 64457192 |
Abdominal discomfort | 44.21 | 13.33 | 28 | 39092 | 182294 | 64277318 |
Hepatic failure | 43.82 | 13.33 | 101 | 39019 | 55293 | 64404319 |
Hypercholesterolaemia | 43.32 | 13.33 | 50 | 39070 | 15323 | 64444289 |
Drug reaction with eosinophilia and systemic symptoms | 41.95 | 13.33 | 98 | 39022 | 54119 | 64405493 |
Infection | 41.36 | 13.33 | 31 | 39089 | 184849 | 64274763 |
Hepatomegaly | 41.15 | 13.33 | 51 | 39069 | 16831 | 64442781 |
Progressive multifocal leukoencephalopathy | 41.14 | 13.33 | 53 | 39067 | 18179 | 64441433 |
Trisomy 21 | 40.78 | 13.33 | 9 | 39111 | 50 | 64459562 |
Spina bifida | 40.49 | 13.33 | 9 | 39111 | 52 | 64459560 |
Injection site pain | 40.47 | 13.33 | 9 | 39111 | 111399 | 64348213 |
Cachexia | 40.43 | 13.33 | 38 | 39082 | 9179 | 64450433 |
Hepatitis | 40.43 | 13.33 | 87 | 39033 | 45495 | 64414117 |
Hyperlipidaemia | 40.10 | 13.33 | 59 | 39061 | 22917 | 64436695 |
Cytomegalovirus chorioretinitis | 39.98 | 13.33 | 29 | 39091 | 4883 | 64454729 |
Immunosuppressant drug level increased | 39.91 | 13.33 | 34 | 39086 | 7225 | 64452387 |
Alanine aminotransferase increased | 39.42 | 13.33 | 178 | 38942 | 138853 | 64320759 |
HIV wasting syndrome | 39.25 | 13.33 | 9 | 39111 | 61 | 64459551 |
Paranoia | 39.21 | 13.33 | 49 | 39071 | 16303 | 64443309 |
Atypical mycobacterial infection | 38.99 | 13.33 | 18 | 39102 | 1290 | 64458322 |
Therapeutic product effect incomplete | 38.32 | 13.33 | 8 | 39112 | 103474 | 64356138 |
Maternal drugs affecting foetus | 38.27 | 13.33 | 19 | 39101 | 1601 | 64458011 |
Hepatic cirrhosis | 38.15 | 13.33 | 62 | 39058 | 26236 | 64433376 |
Hepatitis B | 38.01 | 13.33 | 34 | 39086 | 7711 | 64451901 |
Twin pregnancy | 36.13 | 13.33 | 15 | 39105 | 832 | 64458780 |
Anal cancer stage 0 | 35.96 | 13.33 | 7 | 39113 | 18 | 64459594 |
Aspartate aminotransferase increased | 35.95 | 13.33 | 156 | 38964 | 119632 | 64339980 |
Pneumonia | 35.50 | 13.33 | 197 | 38923 | 559379 | 63900233 |
Psychotic disorder | 35.37 | 13.33 | 70 | 39050 | 34508 | 64425104 |
Depressive symptom | 35.36 | 13.33 | 26 | 39094 | 4470 | 64455142 |
Blood creatine phosphokinase increased | 35.02 | 13.33 | 96 | 39024 | 58462 | 64401150 |
Urinary tract infection | 34.94 | 13.33 | 54 | 39066 | 231542 | 64228070 |
Transaminases increased | 34.93 | 13.33 | 81 | 39039 | 44513 | 64415099 |
Feeling abnormal | 34.52 | 13.33 | 19 | 39101 | 133583 | 64326029 |
Hypothalamic pituitary adrenal axis suppression | 34.52 | 13.33 | 11 | 39109 | 283 | 64459329 |
Contusion | 34.44 | 13.33 | 13 | 39107 | 113952 | 64345660 |
Alopecia | 34.29 | 13.33 | 30 | 39090 | 165660 | 64293952 |
Genital herpes simplex | 33.92 | 13.33 | 11 | 39109 | 300 | 64459312 |
Vanishing bile duct syndrome | 33.23 | 13.33 | 16 | 39104 | 1261 | 64458351 |
Febrile neutropenia | 33.12 | 13.33 | 39 | 39081 | 187618 | 64271994 |
Cough | 33.08 | 13.33 | 85 | 39035 | 302063 | 64157549 |
Fat tissue increased | 32.85 | 13.33 | 14 | 39106 | 829 | 64458783 |
Total bile acids increased | 32.60 | 13.33 | 8 | 39112 | 75 | 64459537 |
CSF test abnormal | 32.56 | 13.33 | 12 | 39108 | 483 | 64459129 |
Psoriasis | 32.49 | 13.33 | 3 | 39117 | 71700 | 64387912 |
Inappropriate schedule of product administration | 32.44 | 13.33 | 8 | 39112 | 92278 | 64367334 |
CSF virus identified | 32.34 | 13.33 | 7 | 39113 | 35 | 64459577 |
Malignant neoplasm progression | 32.28 | 13.33 | 14 | 39106 | 112857 | 64346755 |
Rash maculo-papular | 32.10 | 13.33 | 81 | 39039 | 46945 | 64412667 |
Malaria | 31.90 | 13.33 | 11 | 39109 | 364 | 64459248 |
Cardiac failure congestive | 31.72 | 13.33 | 20 | 39100 | 130560 | 64329052 |
Fibrous histiocytoma | 31.56 | 13.33 | 12 | 39108 | 527 | 64459085 |
Anembryonic gestation | 31.45 | 13.33 | 11 | 39109 | 380 | 64459232 |
Blood lactic acid increased | 31.29 | 13.33 | 35 | 39085 | 10366 | 64449246 |
Endometritis decidual | 30.94 | 13.33 | 6 | 39114 | 15 | 64459597 |
HIV infection | 30.80 | 13.33 | 14 | 39106 | 968 | 64458644 |
Blood alkaline phosphatase increased | 30.46 | 13.33 | 89 | 39031 | 56190 | 64403422 |
Anogenital dysplasia | 30.43 | 13.33 | 8 | 39112 | 101 | 64459511 |
Pregnancy on contraceptive | 30.37 | 13.33 | 13 | 39107 | 778 | 64458834 |
Cholestasis | 30.33 | 13.33 | 77 | 39043 | 44795 | 64414817 |
Pancreatitis | 30.12 | 13.33 | 92 | 39028 | 59515 | 64400097 |
Disease progression | 30.11 | 13.33 | 25 | 39095 | 141655 | 64317957 |
Drug hypersensitivity | 29.98 | 13.33 | 62 | 39058 | 237753 | 64221859 |
Genital herpes | 29.95 | 13.33 | 17 | 39103 | 1878 | 64457734 |
Pain in extremity | 29.66 | 13.33 | 90 | 39030 | 302995 | 64156617 |
Anal cancer | 29.66 | 13.33 | 12 | 39108 | 623 | 64458989 |
Fatigue | 29.64 | 13.33 | 301 | 38819 | 748429 | 63711183 |
Sinusitis | 29.50 | 13.33 | 27 | 39093 | 145901 | 64313711 |
Injection site erythema | 29.47 | 13.33 | 4 | 39116 | 70796 | 64388816 |
Hypotension | 29.41 | 13.33 | 125 | 38995 | 380849 | 64078763 |
Osteoporotic fracture | 28.73 | 13.33 | 21 | 39099 | 3577 | 64456035 |
Heart rate increased | 28.60 | 13.33 | 12 | 39108 | 98663 | 64360949 |
Contraindicated product administered | 28.35 | 13.33 | 15 | 39105 | 107814 | 64351798 |
Blood corticotrophin decreased | 27.91 | 13.33 | 10 | 39110 | 371 | 64459241 |
Chest discomfort | 27.90 | 13.33 | 18 | 39102 | 116088 | 64343524 |
Death | 27.89 | 13.33 | 175 | 38945 | 482530 | 63977082 |
Blood antidiuretic hormone increased | 27.76 | 13.33 | 7 | 39113 | 74 | 64459538 |
Diabetes mellitus | 27.64 | 13.33 | 96 | 39024 | 66378 | 64393234 |
Neutropenia neonatal | 27.24 | 13.33 | 6 | 39114 | 33 | 64459579 |
Secondary syphilis | 27.09 | 13.33 | 6 | 39114 | 34 | 64459578 |
Opportunistic infection | 27.02 | 13.33 | 18 | 39102 | 2644 | 64456968 |
Facial wasting | 26.96 | 13.33 | 7 | 39113 | 84 | 64459528 |
Erythema | 26.91 | 13.33 | 45 | 39075 | 187025 | 64272587 |
Lower respiratory tract infection | 26.63 | 13.33 | 12 | 39108 | 94602 | 64365010 |
Lymphadenopathy | 26.40 | 13.33 | 75 | 39045 | 46611 | 64413001 |
Wound | 26.17 | 13.33 | 7 | 39113 | 76470 | 64383142 |
Bronchitis | 25.94 | 13.33 | 17 | 39103 | 108726 | 64350886 |
Hepatic cytolysis | 25.86 | 13.33 | 37 | 39083 | 14012 | 64445600 |
Haemophilic arthropathy | 25.64 | 13.33 | 7 | 39113 | 103 | 64459509 |
Labelled drug-drug interaction medication error | 25.44 | 13.33 | 47 | 39073 | 22015 | 64437597 |
Product dose omission issue | 25.20 | 13.33 | 50 | 39070 | 194697 | 64264915 |
Oropharyngeal candidiasis | 25.05 | 13.33 | 14 | 39106 | 1501 | 64458111 |
Porphyria non-acute | 24.91 | 13.33 | 11 | 39109 | 710 | 64458902 |
Burkitt's lymphoma | 24.64 | 13.33 | 7 | 39113 | 120 | 64459492 |
Ectopic pregnancy | 24.64 | 13.33 | 14 | 39106 | 1550 | 64458062 |
Gamma-glutamyltransferase increased | 24.63 | 13.33 | 75 | 39045 | 48435 | 64411177 |
Encephalitis | 24.46 | 13.33 | 34 | 39086 | 12537 | 64447075 |
Hypoglycaemia | 24.38 | 13.33 | 12 | 39108 | 89880 | 64369732 |
Ocular icterus | 24.27 | 13.33 | 22 | 39098 | 5076 | 64454536 |
Oesophageal atresia | 24.19 | 13.33 | 6 | 39114 | 59 | 64459553 |
Rhabdomyolysis | 24.19 | 13.33 | 115 | 39005 | 91611 | 64368001 |
Threatened labour | 24.08 | 13.33 | 10 | 39110 | 555 | 64459057 |
Face oedema | 23.98 | 13.33 | 49 | 39071 | 24712 | 64434900 |
Anogenital warts | 23.66 | 13.33 | 11 | 39109 | 801 | 64458811 |
Castleman's disease | 23.44 | 13.33 | 5 | 39115 | 23 | 64459589 |
Musculoskeletal pain | 23.37 | 13.33 | 10 | 39110 | 81284 | 64378328 |
Chlamydial infection | 23.24 | 13.33 | 9 | 39111 | 416 | 64459196 |
Pulmonary sequestration | 23.10 | 13.33 | 5 | 39115 | 25 | 64459587 |
Anaemia neonatal | 23.10 | 13.33 | 5 | 39115 | 25 | 64459587 |
Arthritis | 23.02 | 13.33 | 11 | 39109 | 83803 | 64375809 |
Placental disorder | 22.94 | 13.33 | 11 | 39109 | 859 | 64458753 |
Nodular regenerative hyperplasia | 22.94 | 13.33 | 11 | 39109 | 859 | 64458753 |
Posterior cortical atrophy | 22.86 | 13.33 | 4 | 39116 | 4 | 64459608 |
Placental chorioangioma | 22.86 | 13.33 | 4 | 39116 | 4 | 64459608 |
Superior mesenteric artery syndrome | 22.67 | 13.33 | 7 | 39113 | 162 | 64459450 |
Oxygen saturation decreased | 22.66 | 13.33 | 19 | 39101 | 107157 | 64352455 |
Teratogenicity | 22.52 | 13.33 | 6 | 39114 | 80 | 64459532 |
Stomatitis | 22.48 | 13.33 | 20 | 39100 | 109585 | 64350027 |
HIV associated nephropathy | 22.42 | 13.33 | 8 | 39112 | 293 | 64459319 |
Jarisch-Herxheimer reaction | 22.20 | 13.33 | 10 | 39110 | 677 | 64458935 |
Blood phosphorus decreased | 22.16 | 13.33 | 22 | 39098 | 5683 | 64453929 |
Dyschromatopsia | 21.94 | 13.33 | 10 | 39110 | 696 | 64458916 |
Stress | 21.76 | 13.33 | 5 | 39115 | 60529 | 64399083 |
Retroviral infection | 21.59 | 13.33 | 4 | 39116 | 7 | 64459605 |
Pleural effusion | 21.58 | 13.33 | 27 | 39093 | 126532 | 64333080 |
Wheezing | 21.49 | 13.33 | 11 | 39109 | 80568 | 64379044 |
Pneumococcal sepsis | 21.43 | 13.33 | 12 | 39108 | 1292 | 64458320 |
Product use issue | 21.35 | 13.33 | 37 | 39083 | 151678 | 64307934 |
Intentional product use issue | 21.30 | 13.33 | 16 | 39104 | 95348 | 64364264 |
Atypical mycobacterial lymphadenitis | 21.24 | 13.33 | 4 | 39116 | 8 | 64459604 |
Death neonatal | 21.19 | 13.33 | 5 | 39115 | 39 | 64459573 |
Blood creatinine increased | 21.16 | 13.33 | 148 | 38972 | 135634 | 64323978 |
Immune reconstitution inflammatory syndrome associated tuberculosis | 21.07 | 13.33 | 10 | 39110 | 763 | 64458849 |
Mobility decreased | 21.05 | 13.33 | 13 | 39107 | 85827 | 64373785 |
Subchorionic haematoma | 20.90 | 13.33 | 6 | 39114 | 107 | 64459505 |
Off label use | 20.83 | 13.33 | 265 | 38855 | 632541 | 63827071 |
Intentional product misuse | 20.61 | 13.33 | 9 | 39111 | 72286 | 64387326 |
Flushing | 20.58 | 13.33 | 11 | 39109 | 78637 | 64380975 |
Meningitis cryptococcal | 20.56 | 13.33 | 16 | 39104 | 2993 | 64456619 |
Pancytopenia | 20.49 | 13.33 | 153 | 38967 | 143156 | 64316456 |
Nervous system disorder | 20.40 | 13.33 | 44 | 39076 | 23034 | 64436578 |
Ascites | 20.34 | 13.33 | 83 | 39037 | 61918 | 64397694 |
Musculoskeletal stiffness | 20.27 | 13.33 | 27 | 39093 | 123179 | 64336433 |
CD4 lymphocytes abnormal | 20.27 | 13.33 | 5 | 39115 | 48 | 64459564 |
Coagulation factor V level decreased | 20.25 | 13.33 | 9 | 39111 | 590 | 64459022 |
Kidney fibrosis | 20.14 | 13.33 | 16 | 39104 | 3085 | 64456527 |
Glucocorticoids increased | 19.98 | 13.33 | 6 | 39114 | 126 | 64459486 |
Abortion threatened | 19.96 | 13.33 | 8 | 39112 | 405 | 64459207 |
Anaemia | 19.77 | 13.33 | 331 | 38789 | 378349 | 64081263 |
Benign prostatic hyperplasia | 19.68 | 13.33 | 26 | 39094 | 9139 | 64450473 |
Malignant anorectal neoplasm | 19.65 | 13.33 | 5 | 39115 | 55 | 64459557 |
Alpha 1 foetoprotein abnormal | 19.57 | 13.33 | 5 | 39115 | 56 | 64459556 |
Generalised anxiety disorder | 19.56 | 13.33 | 13 | 39107 | 1902 | 64457710 |
Pulmonary tuberculosis | 19.47 | 13.33 | 23 | 39097 | 7221 | 64452391 |
Erythema elevatum diutinum | 19.41 | 13.33 | 4 | 39116 | 15 | 64459597 |
Upper respiratory tract infection | 19.31 | 13.33 | 10 | 39110 | 72775 | 64386837 |
Amniotic fluid volume decreased | 19.28 | 13.33 | 7 | 39113 | 270 | 64459342 |
Retinal telangiectasia | 19.23 | 13.33 | 3 | 39117 | 0 | 64459612 |
Hyperuricaemia | 18.99 | 13.33 | 27 | 39093 | 10164 | 64449448 |
Tubulointerstitial nephritis | 18.80 | 13.33 | 51 | 39069 | 30858 | 64428754 |
Potassium wasting nephropathy | 18.70 | 13.33 | 6 | 39114 | 158 | 64459454 |
Testicular mass | 18.68 | 13.33 | 5 | 39115 | 68 | 64459544 |
Hepatitis acute | 18.65 | 13.33 | 31 | 39089 | 13358 | 64446254 |
Condition aggravated | 18.53 | 13.33 | 141 | 38979 | 372285 | 64087327 |
Nephrocalcinosis | 18.52 | 13.33 | 11 | 39109 | 1323 | 64458289 |
Varices oesophageal | 18.49 | 13.33 | 19 | 39101 | 5111 | 64454501 |
Depression | 18.46 | 13.33 | 181 | 38939 | 183110 | 64276502 |
Chest pain | 18.45 | 13.33 | 77 | 39043 | 235903 | 64223709 |
Placental insufficiency | 18.45 | 13.33 | 10 | 39110 | 1010 | 64458602 |
Dizziness | 18.19 | 13.33 | 170 | 38950 | 429993 | 64029619 |
Oral candidiasis | 18.00 | 13.33 | 42 | 39078 | 23170 | 64436442 |
HIV viraemia | 17.98 | 13.33 | 5 | 39115 | 79 | 64459533 |
Liver disorder | 17.96 | 13.33 | 72 | 39048 | 53279 | 64406333 |
Viral load decreased | 17.87 | 13.33 | 4 | 39116 | 24 | 64459588 |
Chronic hepatitis C | 17.85 | 13.33 | 8 | 39112 | 535 | 64459077 |
Hepatosplenomegaly | 17.85 | 13.33 | 19 | 39101 | 5324 | 64454288 |
Rhinorrhoea | 17.85 | 13.33 | 7 | 39113 | 59962 | 64399650 |
Haematochezia | 17.79 | 13.33 | 9 | 39111 | 66364 | 64393248 |
Eosinophilia | 17.61 | 13.33 | 57 | 39063 | 38019 | 64421593 |
Vitamin D deficiency | 17.55 | 13.33 | 28 | 39092 | 11664 | 64447948 |
Drug intolerance | 17.54 | 13.33 | 57 | 39063 | 187935 | 64271677 |
Pericarditis | 17.48 | 13.33 | 8 | 39112 | 62508 | 64397104 |
Hepatitis B reactivation | 17.43 | 13.33 | 18 | 39102 | 4871 | 64454741 |
Hepatic cancer | 17.35 | 13.33 | 22 | 39098 | 7426 | 64452186 |
Hodgkin's disease | 17.35 | 13.33 | 9 | 39111 | 832 | 64458780 |
5'nucleotidase increased | 17.15 | 13.33 | 3 | 39117 | 3 | 64459609 |
ECG signs of ventricular hypertrophy | 17.15 | 13.33 | 3 | 39117 | 3 | 64459609 |
Immunoblastic lymphoma | 17.15 | 13.33 | 3 | 39117 | 3 | 64459609 |
Treponema test positive | 17.15 | 13.33 | 3 | 39117 | 3 | 64459609 |
Chronic kidney disease | 17.03 | 13.33 | 75 | 39045 | 57844 | 64401768 |
Haemolytic anaemia | 17.02 | 13.33 | 33 | 39087 | 16020 | 64443592 |
Prurigo | 16.80 | 13.33 | 10 | 39110 | 1207 | 64458405 |
Acquired gene mutation | 16.79 | 13.33 | 12 | 39108 | 1974 | 64457638 |
Hepatitis cholestatic | 16.74 | 13.33 | 28 | 39092 | 12127 | 64447485 |
Hepatic steatosis | 16.74 | 13.33 | 49 | 39071 | 30958 | 64428654 |
Epistaxis | 16.66 | 13.33 | 21 | 39099 | 98110 | 64361502 |
Tuberculosis | 16.60 | 13.33 | 29 | 39091 | 13009 | 64446603 |
Eosinophilic pustular folliculitis | 16.56 | 13.33 | 5 | 39115 | 107 | 64459505 |
Osteopenia | 16.55 | 13.33 | 32 | 39088 | 15508 | 64444104 |
Drug level decreased | 16.52 | 13.33 | 27 | 39093 | 11476 | 64448136 |
Pneumonitis | 16.51 | 13.33 | 5 | 39115 | 50360 | 64409252 |
Glucose urine present | 16.48 | 13.33 | 11 | 39109 | 1621 | 64457991 |
Congenital hydrocephalus | 16.45 | 13.33 | 4 | 39116 | 36 | 64459576 |
Mycobacterial infection | 16.44 | 13.33 | 14 | 39106 | 2974 | 64456638 |
Cell death | 16.43 | 13.33 | 16 | 39104 | 4038 | 64455574 |
Discomfort | 16.30 | 13.33 | 15 | 39105 | 80863 | 64378749 |
Gene mutation | 16.28 | 13.33 | 12 | 39108 | 2070 | 64457542 |
Gestational hypertension | 16.19 | 13.33 | 11 | 39109 | 1670 | 64457942 |
Burning sensation | 16.15 | 13.33 | 5 | 39115 | 49659 | 64409953 |
Anticoagulation drug level increased | 16.15 | 13.33 | 8 | 39112 | 671 | 64458941 |
Crystal urine | 16.06 | 13.33 | 5 | 39115 | 119 | 64459493 |
Liver function test abnormal | 16.04 | 13.33 | 75 | 39045 | 59326 | 64400286 |
Foetal distress syndrome | 15.96 | 13.33 | 7 | 39113 | 445 | 64459167 |
Bulbar palsy | 15.95 | 13.33 | 6 | 39114 | 256 | 64459356 |
White matter lesion | 15.94 | 13.33 | 11 | 39109 | 1711 | 64457901 |
Foetal growth restriction | 15.90 | 13.33 | 11 | 39109 | 1719 | 64457893 |
Splenomegaly | 15.60 | 13.33 | 34 | 39086 | 17927 | 64441685 |
Osteomalacia | 15.57 | 13.33 | 10 | 39110 | 1381 | 64458231 |
Foetal disorder | 15.57 | 13.33 | 5 | 39115 | 132 | 64459480 |
CD4 lymphocytes increased | 15.54 | 13.33 | 6 | 39114 | 275 | 64459337 |
Trichomoniasis | 15.53 | 13.33 | 5 | 39115 | 133 | 64459479 |
Neck pain | 15.53 | 13.33 | 9 | 39111 | 61524 | 64398088 |
Pneumonia pneumococcal | 15.48 | 13.33 | 14 | 39106 | 3220 | 64456392 |
New onset diabetes after transplantation | 15.46 | 13.33 | 5 | 39115 | 135 | 64459477 |
Seborrhoeic dermatitis | 15.36 | 13.33 | 11 | 39109 | 1815 | 64457797 |
Lymphogranuloma venereum | 15.33 | 13.33 | 3 | 39117 | 8 | 64459604 |
Back pain | 15.30 | 13.33 | 89 | 39031 | 250082 | 64209530 |
Lipids abnormal | 15.20 | 13.33 | 7 | 39113 | 499 | 64459113 |
Hepatic encephalopathy | 15.13 | 13.33 | 37 | 39083 | 21029 | 64438583 |
Loss of personal independence in daily activities | 15.12 | 13.33 | 13 | 39107 | 72441 | 64387171 |
Hypo HDL cholesterolaemia | 15.07 | 13.33 | 3 | 39117 | 9 | 64459603 |
Nephrogenic diabetes insipidus | 15.04 | 13.33 | 11 | 39109 | 1876 | 64457736 |
Post transplant distal limb syndrome | 14.89 | 13.33 | 7 | 39113 | 523 | 64459089 |
Encephalitis viral | 14.86 | 13.33 | 12 | 39108 | 2368 | 64457244 |
Complication of pregnancy | 14.80 | 13.33 | 6 | 39114 | 313 | 64459299 |
Arterial spasm | 14.75 | 13.33 | 5 | 39115 | 157 | 64459455 |
AIDS related complication | 14.71 | 13.33 | 4 | 39116 | 58 | 64459554 |
Nasal congestion | 14.67 | 13.33 | 9 | 39111 | 59649 | 64399963 |
Drug abuse | 14.65 | 13.33 | 37 | 39083 | 132337 | 64327275 |
Acute myocardial infarction | 14.61 | 13.33 | 82 | 39038 | 69636 | 64389976 |
Metabolic acidosis | 14.57 | 13.33 | 83 | 39037 | 70875 | 64388737 |
Speech disorder developmental | 14.53 | 13.33 | 7 | 39113 | 552 | 64459060 |
Conduction disorder | 14.50 | 13.33 | 13 | 39107 | 2955 | 64456657 |
Intentional overdose | 14.50 | 13.33 | 20 | 39100 | 89924 | 64369688 |
Dermatitis exfoliative | 14.46 | 13.33 | 24 | 39096 | 10328 | 64449284 |
Anaemia of pregnancy | 14.46 | 13.33 | 4 | 39116 | 62 | 64459550 |
Suicidal ideation | 14.44 | 13.33 | 79 | 39041 | 66463 | 64393149 |
Prognathism | 14.40 | 13.33 | 3 | 39117 | 12 | 64459600 |
Blood HIV RNA | 14.40 | 13.33 | 3 | 39117 | 12 | 64459600 |
Wrong technique in product usage process | 14.38 | 13.33 | 11 | 39109 | 64963 | 64394649 |
Amylase increased | 14.27 | 13.33 | 23 | 39097 | 9662 | 64449950 |
Urinary retention | 14.22 | 13.33 | 6 | 39114 | 49195 | 64410417 |
Cholelithiasis | 14.21 | 13.33 | 60 | 39060 | 45446 | 64414166 |
Balance disorder | 14.21 | 13.33 | 18 | 39102 | 83908 | 64375704 |
Portal fibrosis | 14.17 | 13.33 | 7 | 39113 | 583 | 64459029 |
Haemoptysis | 14.15 | 13.33 | 6 | 39114 | 49042 | 64410570 |
Eyelid oedema | 13.96 | 13.33 | 26 | 39094 | 12253 | 64447359 |
Oesophageal ulcer | 13.93 | 13.33 | 18 | 39102 | 6192 | 64453420 |
Intussusception | 13.92 | 13.33 | 8 | 39112 | 905 | 64458707 |
Nephropathy | 13.87 | 13.33 | 21 | 39099 | 8365 | 64451247 |
Paternal drugs affecting foetus | 13.86 | 13.33 | 3 | 39117 | 15 | 64459597 |
Congenital diaphragmatic hernia | 13.86 | 13.33 | 3 | 39117 | 15 | 64459597 |
Cardio-respiratory arrest | 13.83 | 13.33 | 24 | 39096 | 98369 | 64361243 |
Osteoarthritis | 13.67 | 13.33 | 11 | 39109 | 63325 | 64396287 |
Ureterolithiasis | 13.66 | 13.33 | 13 | 39107 | 3188 | 64456424 |
Neutrophil count decreased | 13.65 | 13.33 | 16 | 39104 | 77180 | 64382432 |
Interstitial lung disease | 13.59 | 13.33 | 24 | 39096 | 97708 | 64361904 |
Acute stress disorder | 13.45 | 13.33 | 6 | 39114 | 397 | 64459215 |
Hirsutism | 13.45 | 13.33 | 8 | 39112 | 965 | 64458647 |
Acute haemorrhagic conjunctivitis | 13.40 | 13.33 | 3 | 39117 | 18 | 64459594 |
Plasmablastic lymphoma | 13.36 | 13.33 | 6 | 39114 | 403 | 64459209 |
Cerebrovascular accident | 13.33 | 13.33 | 41 | 39079 | 137542 | 64322070 |
None
Source | Code | Description |
---|---|---|
ATC | J05AE03 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Protease inhibitors |
ATC | J05AP52 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HCV infections |
ATC | J05AP53 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HCV infections |
ATC | J05AR10 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
ATC | J05AR23 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
ATC | J05AR26 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HIV infections, combinations |
FDA MoA | N0000000246 | HIV Protease Inhibitors |
FDA EPC | N0000175889 | Protease Inhibitor |
FDA MoA | N0000182137 | Cytochrome P450 2D6 Inhibitors |
FDA MoA | N0000182141 | Cytochrome P450 3A4 Inhibitors |
FDA MoA | N0000185503 | P-Glycoprotein Inhibitors |
FDA MoA | N0000185507 | Cytochrome P450 2C9 Inducers |
FDA MoA | N0000185607 | Cytochrome P450 2C19 Inducers |
FDA MoA | N0000187064 | Cytochrome P450 2B6 Inducers |
FDA MoA | N0000190113 | Breast Cancer Resistance Protein Inhibitors |
FDA MoA | N0000190114 | Cytochrome P450 3A Inhibitors |
FDA MoA | N0000190117 | UDP Glucuronosyltransferases Inducers |
FDA MoA | N0000190118 | Cytochrome P450 3A Inducers |
FDA EPC | N0000191001 | Cytochrome P450 3A Inhibitor |
FDA MoA | N0000191266 | Cytochrome P450 1A2 Inducers |
CHEBI has role | CHEBI:35660 | HIV protease inhibitors |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:36044 | antiviral drugs |
CHEBI has role | CHEBI:78298 | environmental contaminants |
MeSH PA | D019380 | Anti-HIV Agents |
MeSH PA | D000890 | Anti-Infective Agents |
MeSH PA | D044966 | Anti-Retroviral Agents |
MeSH PA | D000998 | Antiviral Agents |
MeSH PA | D065692 | Cytochrome P-450 CYP3A Inhibitors |
MeSH PA | D065607 | Cytochrome P-450 Enzyme Inhibitors |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D017320 | HIV Protease Inhibitors |
MeSH PA | D065606 | Metabolic Side Effects of Drugs and Substances |
MeSH PA | D011480 | Protease Inhibitors |
MeSH PA | D000084762 | Viral Protease Inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Human immunodeficiency virus infection | indication | 86406008 | DOID:526 |
Chronic hepatitis C | indication | 128302006 | |
COVID-19 | indication | 840539006 | |
Prevention of HIV Infection after Exposure | off-label use | ||
Hypercholesterolemia | contraindication | 13644009 | |
Hyperbilirubinemia | contraindication | 14783006 | DOID:2741 |
Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
Complete atrioventricular block | contraindication | 27885002 | |
Hereditary factor VIII deficiency disease | contraindication | 28293008 | DOID:12134 |
Torsades de pointes | contraindication | 31722008 | |
Hyperuricemia | contraindication | 35885006 | DOID:1920 |
Hereditary factor IX deficiency disease | contraindication | 41788008 | DOID:12259 |
Hypokalemia | contraindication | 43339004 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Chronic type B viral hepatitis | contraindication | 61977001 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Pancreatitis | contraindication | 75694006 | DOID:4989 |
Hyperglycemia | contraindication | 80394007 | DOID:4195 |
Cardiomyopathy | contraindication | 85898001 | DOID:0050700 |
Gout | contraindication | 90560007 | DOID:13189 |
Prolonged QT interval | contraindication | 111975006 | |
Structural disorder of heart | contraindication | 128599005 | |
Liver function tests abnormal | contraindication | 166603001 | |
Hypomagnesemia | contraindication | 190855004 | |
Second degree atrioventricular block | contraindication | 195042002 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Mixed hyperlipidemia | contraindication | 267434003 | |
Hypertriglyceridemia | contraindication | 302870006 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
Congenital long QT syndrome | contraindication | 442917000 | |
First Degree Atrioventricular Heart Block | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 12.39 | acidic |
pKa2 | 13.84 | acidic |
pKa3 | 3.62 | Basic |
pKa4 | 2.45 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
EQ 200MG BASE;8.33MG;50MG;33.33MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | VIEKIRA XR | ABBVIE INC | N208624 | July 22, 2016 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 8501238 | Sept. 17, 2028 | USE OF DASABUVIR TO INHIBIT VIRAL REPLICATION FOR THE TREATMENT OF HCV INFECTION. |
EQ 250MG BASE;12.5MG, 75MG, 50MG | VIEKIRA PAK (COPACKAGED) | ABBVIE INC | N206619 | Dec. 19, 2014 | DISCN | TABLET | ORAL | 9139536 | Nov. 9, 2028 | TREATMENT OF HCV INFECTION USING DASABUVIR |
EQ 200MG BASE;8.33MG;50MG;33.33MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | VIEKIRA XR | ABBVIE INC | N208624 | July 22, 2016 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 9139536 | Nov. 9, 2028 | TREATMENT OF HCV INFECTION USING DASABUVIR |
EQ 250MG BASE;12.5MG, 75MG, 50MG | VIEKIRA PAK (COPACKAGED) | ABBVIE INC | N206619 | Dec. 19, 2014 | DISCN | TABLET | ORAL | 8501238 | Dec. 19, 2028 | USE OF DASABUVIR TO INHIBIT VIRAL REPLICATION FOR THE TREATMENT OF HCV INFECTION. |
EQ 250MG BASE;12.5MG, 75MG, 50MG | VIEKIRA PAK (COPACKAGED) | ABBVIE INC | N206619 | Dec. 19, 2014 | DISCN | TABLET | ORAL | 8188104 | May 17, 2029 | USE OF DASABUVIR TO INHIBIT VIRAL REPLICATION FOR THE TREATMENT OF HCV INFECTION. |
EQ 200MG BASE;8.33MG;50MG;33.33MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | VIEKIRA XR | ABBVIE INC | N208624 | July 22, 2016 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 8188104 | May 17, 2029 | USE OF DASABUVIR TO INHIBIT VIRAL REPLICATION FOR THE TREATMENT OF HCV INFECTION. |
EQ 250MG BASE;12.5MG, 75MG, 50MG | VIEKIRA PAK (COPACKAGED) | ABBVIE INC | N206619 | Dec. 19, 2014 | DISCN | TABLET | ORAL | 8642538 | Sept. 10, 2029 | TREATMENT OF HCV INFECTION USING PARITAPREVIR |
12.5MG;75MG;50MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | TECHNIVIE | ABBVIE INC | N207931 | July 24, 2015 | DISCN | TABLET | ORAL | 8642538 | Sept. 10, 2029 | TREATMENT OF HCV INFECTION USING PARITAPREVIR |
EQ 200MG BASE;8.33MG;50MG;33.33MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | VIEKIRA XR | ABBVIE INC | N208624 | July 22, 2016 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 8642538 | Sept. 10, 2029 | TREATMENT OF HCV INFECTION USING PARITAPREVIR |
EQ 250MG BASE;12.5MG, 75MG, 50MG | VIEKIRA PAK (COPACKAGED) | ABBVIE INC | N206619 | Dec. 19, 2014 | DISCN | TABLET | ORAL | 9006387 | June 10, 2030 | TREATMENT OF HCV INFECTION USING OMBITASVIR |
12.5MG;75MG;50MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | TECHNIVIE | ABBVIE INC | N207931 | July 24, 2015 | DISCN | TABLET | ORAL | 9006387 | June 10, 2030 | TREATMENT OF HCV INFECTION USING OMBITASVIR |
EQ 200MG BASE;8.33MG;50MG;33.33MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | VIEKIRA XR | ABBVIE INC | N208624 | July 22, 2016 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 9006387 | June 10, 2030 | TREATMENT OF HCV INFECTION USING OMBITASVIR |
EQ 250MG BASE;12.5MG, 75MG, 50MG | VIEKIRA PAK (COPACKAGED) | ABBVIE INC | N206619 | Dec. 19, 2014 | DISCN | TABLET | ORAL | 9044480 | April 10, 2031 | TREATMENT OF HCV INFECTION USING PARITAPREVIR |
12.5MG;75MG;50MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | TECHNIVIE | ABBVIE INC | N207931 | July 24, 2015 | DISCN | TABLET | ORAL | 9044480 | April 10, 2031 | TREATMENT OF HCV INFECTION USING PARITAPREVIR |
EQ 200MG BASE;8.33MG;50MG;33.33MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | VIEKIRA XR | ABBVIE INC | N208624 | July 22, 2016 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 9044480 | April 10, 2031 | TREATMENT OF HCV INFECTION USING PARITAPREVIR |
EQ 200MG BASE;8.33MG;50MG;33.33MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | VIEKIRA XR | ABBVIE INC | N208624 | July 22, 2016 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 10201584 | May 17, 2032 | TREATMENT OF HCV INFECTION USING DASABUVIR/OMBITASVIR/PARITAPREVIR/RITONAVIR FIXED DOSE COMBINATION |
EQ 250MG BASE;12.5MG, 75MG, 50MG | VIEKIRA PAK (COPACKAGED) | ABBVIE INC | N206619 | Dec. 19, 2014 | DISCN | TABLET | ORAL | 8466159 | Sept. 4, 2032 | TREATMENT OF HCV INFECTION USING PARITAPREVIR, OMBITASVIR, RITONAVIR, AND DASABUVIR WITH RIBAVIRIN. |
EQ 250MG BASE;12.5MG, 75MG, 50MG | VIEKIRA PAK (COPACKAGED) | ABBVIE INC | N206619 | Dec. 19, 2014 | DISCN | TABLET | ORAL | 8492386 | Sept. 4, 2032 | TREATMENT OF HCV INFECTION USING PARITAPREVIR, OMBITASVIR, RITONAVIR, AND DASABUVIR, WITHOUT RIBAVIRIN |
EQ 250MG BASE;12.5MG, 75MG, 50MG | VIEKIRA PAK (COPACKAGED) | ABBVIE INC | N206619 | Dec. 19, 2014 | DISCN | TABLET | ORAL | 8680106 | Sept. 4, 2032 | TREATMENT OF HCV INFECTION USING PARITAPREVIR, OMBITASVIR, RITONAVIR, AND DASABUVIR WITH RIBAVIRIN. |
EQ 250MG BASE;12.5MG, 75MG, 50MG | VIEKIRA PAK (COPACKAGED) | ABBVIE INC | N206619 | Dec. 19, 2014 | DISCN | TABLET | ORAL | 8685984 | Sept. 4, 2032 | TREATMENT OF HCV INFECTION USING PARITAPREVIR, OMBITASVIR, RITONAVIR, AND DASABUVIR, WITHOUT RIBAVIRIN |
EQ 200MG BASE;8.33MG;50MG;33.33MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | VIEKIRA XR | ABBVIE INC | N208624 | July 22, 2016 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 8466159 | Sept. 4, 2032 | TREATMENT OF HCV INFECTION USING PARITAPREVIR, OMBITASVIR, RITONAVIR, AND DASABUVIR WITH RIBAVIRIN. |
EQ 200MG BASE;8.33MG;50MG;33.33MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | VIEKIRA XR | ABBVIE INC | N208624 | July 22, 2016 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 8492386 | Sept. 4, 2032 | TREATMENT OF HCV INFECTION USING PARITAPREVIR, OMBITASVIR, RITONAVIR, AND DASABUVIR, WITHOUT RIBAVIRIN |
EQ 200MG BASE;8.33MG;50MG;33.33MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | VIEKIRA XR | ABBVIE INC | N208624 | July 22, 2016 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 8680106 | Sept. 4, 2032 | TREATMENT OF HCV INFECTION USING PARITAPREVIR, OMBITASVIR, RITONAVIR, AND DASABUVIR WITH RIBAVIRIN. |
EQ 200MG BASE;8.33MG;50MG;33.33MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | VIEKIRA XR | ABBVIE INC | N208624 | July 22, 2016 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 8685984 | Sept. 4, 2032 | TREATMENT OF HCV INFECTION USING PARITAPREVIR, OMBITASVIR, RITONAVIR, AND DASABUVIR, WITHOUT RIBAVIRIN |
EQ 250MG BASE;12.5MG, 75MG, 50MG | VIEKIRA PAK (COPACKAGED) | ABBVIE INC | N206619 | Dec. 19, 2014 | DISCN | TABLET | ORAL | 10201542 | Oct. 18, 2033 | TREATMENT OF HCV INFECTION USING DASABUVIR |
EQ 250MG BASE;12.5MG, 75MG, 50MG | VIEKIRA PAK (COPACKAGED) | ABBVIE INC | N206619 | Dec. 19, 2014 | DISCN | TABLET | ORAL | 9629841 | Oct. 18, 2033 | TREATMENT OF HCV INFECTION USING DASABUVIR |
EQ 200MG BASE;8.33MG;50MG;33.33MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | VIEKIRA XR | ABBVIE INC | N208624 | July 22, 2016 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 10105365 | Jan. 2, 2035 | TREATMENT OF HCV INFECTION USING DASABUVIR/OMBITASVIR/PARITAPREVIR/RITONAVIR FIXED DOSE COMBINATION |
EQ 200MG BASE;8.33MG;50MG;33.33MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | VIEKIRA XR | ABBVIE INC | N208624 | July 22, 2016 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 9333204 | Jan. 2, 2035 | TREATMENT OF HCV INFECTION USING DASABUVIR/OMBITASVIR/PARITAPREVIR/RITONAVIR FIXED DOSE COMBINATION |
EQ 200MG BASE;8.33MG;50MG;33.33MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | VIEKIRA XR | ABBVIE INC | N208624 | July 22, 2016 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 9744170 | Jan. 2, 2035 | TREATMENT OF HCV INFECTION USING DASABUVIR/OMBITASVIR/PARITAPREVIR/RITONAVIR FIXED DOSE COMBINATION |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Cytochrome P450 3A4 | Enzyme | IC50 | 7.55 | WOMBAT-PK | |||||
Multidrug resistance protein 1 | Transporter | IC50 | 5.83 | WOMBAT-PK | |||||
Cytochrome P450 2D6 | Enzyme | IC50 | 4.30 | DRUG MATRIX | |||||
Nuclear receptor subfamily 1 group I member 2 | Nuclear hormone receptor | WOMBAT-PK | |||||||
Kappa-type opioid receptor | GPCR | Ki | 5.26 | DRUG MATRIX | |||||
Cytochrome P450 2C9 | Enzyme | IC50 | 7.80 | DRUG MATRIX | |||||
Vasopressin V1a receptor | GPCR | Ki | 5.30 | DRUG MATRIX | |||||
Thromboxane-A synthase | Enzyme | IC50 | 7.12 | DRUG MATRIX | |||||
Solute carrier family 22 member 1 | Transporter | IC50 | 4.47 | CHEMBL | |||||
Substance-K receptor | GPCR | Ki | 6.06 | DRUG MATRIX | |||||
Cytochrome P450 3A5 | Enzyme | INHIBITOR | Ki | 6.92 | IUPHAR | ||||
UDP-glucuronosyltransferase 1-1 | Enzyme | INHIBITOR | IC50 | 5.77 | IUPHAR | ||||
Solute carrier family 22 member 2 | Transporter | IC50 | 4.61 | CHEMBL | |||||
Multidrug and toxin extrusion protein 1 | Transporter | IC50 | 7.10 | CHEMBL | |||||
Multidrug and toxin extrusion protein 2 | Transporter | IC50 | 5.36 | CHEMBL | |||||
Mu-type opioid receptor | GPCR | Ki | 4.58 | DRUG MATRIX | |||||
Pol polyprotein | Enzyme | INHIBITOR | Ki | 10.82 | CHEMBL | CHEMBL | |||
Gag-Pol polyprotein | Polyprotein | Ki | 9.23 | WOMBAT-PK | |||||
Protease | Enzyme | Ki | 10.47 | CHEMBL |
ID | Source |
---|---|
4020963 | VUID |
N0000148436 | NUI |
D00427 | KEGG_DRUG |
4020963 | VANDF |
C0292818 | UMLSCUI |
CHEBI:45409 | CHEBI |
RIT | PDB_CHEM_ID |
CHEMBL163 | ChEMBL_ID |
D019438 | MESH_DESCRIPTOR_UI |
DB00503 | DRUGBANK_ID |
8804 | IUPHAR_LIGAND_ID |
7449 | INN_ID |
O3J8G9O825 | UNII |
392622 | PUBCHEM_CID |
196479 | RXNORM |
251788 | MMSL |
5431 | MMSL |
6452 | MMSL |
d03984 | MMSL |
005554 | NDDF |
108693005 | SNOMEDCT_US |
386896009 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Ritonavir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0407 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 30 sections |
Ritonavir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0407 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 30 sections |
Kaletra | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0074-0522 | TABLET, FILM COATED | 25 mg | ORAL | NDA | 32 sections |
Kaletra | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0074-1575 | TABLET, FILM COATED | 25 mg | ORAL | NDA | 32 sections |
Norvir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-1940 | SOLUTION | 80 mg | ORAL | NDA | 29 sections |
Kaletra | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0074-2605 | TABLET, FILM COATED | 50 mg | ORAL | NDA | 32 sections |
Norvir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-3333 | TABLET, FILM COATED | 100 mg | ORAL | NDA | 29 sections |
Norvir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-3399 | POWDER | 100 mg | ORAL | NDA | 29 sections |
Kaletra | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0074-3956 | SOLUTION | 20 mg | ORAL | NDA | 32 sections |
Kaletra | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0074-6799 | TABLET, FILM COATED | 50 mg | ORAL | NDA | 32 sections |
Lopinavir-Ritonavir | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0527-1947 | SOLUTION | 20 mg | ORAL | ANDA | 27 sections |
Lopinavir-Ritonavir | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0527-1947 | SOLUTION | 20 mg | ORAL | ANDA | 27 sections |
Kaletra | HUMAN PRESCRIPTION DRUG LABEL | 2 | 11819-342 | TABLET, FILM COATED | 50 mg | ORAL | NDA | 27 sections |
Kaletra | HUMAN PRESCRIPTION DRUG LABEL | 2 | 21695-362 | TABLET, FILM COATED | 50 mg | ORAL | NDA | 27 sections |
Lopinavir and ritonavir | HUMAN PRESCRIPTION DRUG LABEL | 2 | 31722-556 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 27 sections |
Ritonavir | Human Prescription Drug Label | 1 | 31722-597 | TABLET | 100 mg | ORAL | ANDA | 26 sections |
Lopinavir and ritonavir | HUMAN PRESCRIPTION DRUG LABEL | 2 | 31722-603 | TABLET, FILM COATED | 25 mg | ORAL | ANDA | 27 sections |
Lopinavir and Ritonavir | Human Prescription Drug Label | 2 | 42385-933 | TABLET, FILM COATED | 25 mg | ORAL | ANDA | 28 sections |
Lopinavir and Ritonavir | Human Prescription Drug Label | 2 | 42385-934 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 28 sections |
Kaletra | HUMAN PRESCRIPTION DRUG LABEL | 2 | 53808-0276 | TABLET, FILM COATED | 50 mg | ORAL | NDA | 27 sections |
Norvir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 53808-1119 | TABLET, FILM COATED | 100 mg | ORAL | NDA | 28 sections |
Kaletra | HUMAN PRESCRIPTION DRUG LABEL | 2 | 54868-5566 | TABLET, FILM COATED | 50 mg | ORAL | NDA | 27 sections |
Kaletra | HUMAN PRESCRIPTION DRUG LABEL | 2 | 55289-947 | TABLET, FILM COATED | 50 mg | ORAL | NDA | 27 sections |
Ritonavir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60687-364 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 29 sections |
Ritonavir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60687-420 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 30 sections |
Lopinavir and Ritonavir | HUMAN PRESCRIPTION DRUG LABEL | 2 | 65015-299 | GRANULE | 10 mg | ORAL | Export only | 1 sections |
Ritonavir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 65162-061 | TABLET | 100 mg | ORAL | ANDA | 28 sections |
Ritonavir | Human Prescription Drug Label | 1 | 65862-687 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 29 sections |
Kaletra | HUMAN PRESCRIPTION DRUG LABEL | 2 | 66336-624 | TABLET, FILM COATED | 50 mg | ORAL | NDA | 27 sections |
Norvir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 67296-1234 | TABLET, FILM COATED | 100 mg | ORAL | NDA | 19 sections |