levisoprenaline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
bronchodilators, phenethylamine derivatives	2388	51-31-0

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

r-isoprenaline
L-Isoproterenol
levisoprenaline

Molecular weight: 211.26
Formula: C11H17NO3
CLOGP: 0.15
LIPINSKI: 0
HAC: 4
HDO: 4
TPSA: 72.72
ALOGS: -1.56
ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
CHEBI has role	CHEBI:35522	beta-adrenergic agonists
CHEBI has role	CHEBI:35524	sympathomimetic

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.97	acidic
pKa2	12.82	acidic
pKa3	13.92	acidic
pKa4	8.94	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Beta-1 adrenergic receptor	GPCR	P08588	ADRB1_HUMAN		EC50	8.10		CHEMBL
Beta-2 adrenergic receptor	GPCR	P07550	ADRB2_HUMAN		IC50	10.30		CHEMBL
Beta-3 adrenergic receptor	GPCR	P13945	ADRB3_HUMAN		EC50	7.40		CHEMBL
Beta-2 adrenergic receptor	GPCR		ADRB2_MESAU		Ki	6.87		CHEMBL
Beta-1 adrenergic receptor	GPCR		ADRB1_MOUSE		Ki	6.66		CHEMBL

External reference:

ID	Source
C2697916	UMLSCUI
CHEBI:6257	CHEBI
5FW	PDB_CHEM_ID
CHEMBL1160723	ChEMBL_ID
CHEMBL460574	ChEMBL_ID
864	INN_ID
588N0603CT	UNII
443372	PUBCHEM_CID

Pharmaceutical products:

None