riboflavin phosphate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2374 130-40-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • riboflavin sodium phosphate
  • RIBOFLAVIN 5'-PHOSPHATE SODIUM
  • riboflavin phosphate
  • vitamin B2 phosphate
  • riboflavin 5'-(dihydrogen phosphate)
  • flavin mononucleotide
A coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.
  • Molecular weight: 456.35
  • Formula: C17H21N4O9P
  • CLOGP: -2.60
  • LIPINSKI: 2
  • HAC: 13
  • HDO: 6
  • TPSA: 201.58
  • ALOGS: -2.83
  • ROTB: 7

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 1953 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pneumonia aspiration 343.22 96.46 50 64 3692 2354279
Gastrooesophageal reflux disease 306.15 96.46 51 63 9044 2348927
Coma 299.05 96.46 50 64 9006 2348965
Somnolence 251.46 96.46 50 64 23435 2334536

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
MeSH PA D018977 Micronutrients
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.57 acidic
pKa2 6.62 acidic
pKa3 10.13 acidic
pKa4 12.34 acidic
pKa5 13.19 acidic
pKa6 2.49 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
0.146% PHOTREXA AVEDRO INC N203324 April 15, 2016 RX SOLUTION/DROPS OPHTHALMIC April 15, 2023 TREATMENT OF PROGRESSIVE KERATOCONUS
0.146% PHOTREXA VISCOUS IN DEXTRAN 20% AVEDRO INC N203324 April 15, 2016 RX SOLUTION/DROPS OPHTHALMIC April 15, 2023 TREATMENT OF PROGRESSIVE KERATOCONUS
0.146% PHOTREXA AVEDRO INC N203324 April 15, 2016 RX SOLUTION/DROPS OPHTHALMIC July 15, 2023 TREATMENT OF CORNEAL ECTASIA FOLLOWING REFRACTIVE SURGERY
0.146% PHOTREXA VISCOUS IN DEXTRAN 20% AVEDRO INC N203324 April 15, 2016 RX SOLUTION/DROPS OPHTHALMIC July 15, 2023 TREATMENT OF CORNEAL ECTASIA FOLLOWING REFRACTIVE SURGERY

Bioactivity Summary:

None

External reference:

IDSource
D005486 MESH_DESCRIPTOR_UI
4017670 VUID
N0000178985 NUI
C0037548 UMLSCUI
D01622 KEGG_DRUG
20RD1DZH99 UNII
6184-17-4 SECONDARY_CAS_RN
53499005 SNOMEDCT_US
4017770 VANDF
014666 NDDF
31895 MMSL
1925821 RXNORM
FMN PDB_CHEM_ID
DB03247 DRUGBANK_ID
CHEBI:32098 CHEBI
CHEMBL1201794 ChEMBL_ID
CHEMBL3989697 ChEMBL_ID
643976 PUBCHEM_CID
5185 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Multi-Vit with Fluoride HUMAN PRESCRIPTION DRUG LABEL 10 0603-1449 SOLUTION 0.60 mg ORAL UNAPPROVED DRUG OTHER 11 sections
Multi-Vit with Fluoride HUMAN PRESCRIPTION DRUG LABEL 10 0603-1450 SOLUTION 0.60 mg ORAL UNAPPROVED DRUG OTHER 11 sections
Multi-Vit with Fluoride and Iron HUMAN PRESCRIPTION DRUG LABEL 10 0603-1452 SOLUTION 0.60 mg ORAL UNAPPROVED DRUG OTHER 11 sections
Photrexa Viscous HUMAN PRESCRIPTION DRUG LABEL 1 25357-022 SOLUTION/ DROPS 1.46 mg OPHTHALMIC NDA 14 sections
Photrexa HUMAN PRESCRIPTION DRUG LABEL 1 25357-023 SOLUTION/ DROPS 1.46 mg OPHTHALMIC NDA 14 sections
Photrexa Cross-linking Kit HUMAN PRESCRIPTION DRUG LABEL 2 25357-025 KIT 1.46 mg OPHTHALMIC NDA 14 sections
Photrexa Cross-linking Kit HUMAN PRESCRIPTION DRUG LABEL 2 25357-025 KIT 1.56 mg OPHTHALMIC NDA 14 sections
B-PLEX 100 HUMAN PRESCRIPTION DRUG LABEL 5 30727-300 INJECTION, SOLUTION 2 mg INTRAMUSCULAR unapproved drug other 10 sections
PEDIATRIC INFUVITE MULTIPLE VITAMINS FOR INFUSION HUMAN PRESCRIPTION DRUG LABEL 12 54643-5646 INJECTION, SOLUTION 1.40 mg INTRAVENOUS NDA 14 sections
Pediatric Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 12 54643-5647 KIT 1.40 mg None NDA 14 sections
Adult Infuvite Multiple Vitamins for Infusion HUMAN PRESCRIPTION DRUG LABEL 13 54643-5649 INJECTION, SOLUTION 3.60 mg INTRAVENOUS NDA 11 sections
Infuvite Adult Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 12 54643-5650 INJECTION, SOLUTION 3.60 mg INTRAVENOUS NDA 14 sections
Adult Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 12 54643-7862 INJECTION, SOLUTION 3.60 mg INTRAVENOUS NDA 14 sections
Adult Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 12 54643-7874 INJECTION, SOLUTION 3.60 mg INTRAVENOUS NDA 14 sections
Pediatric Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 12 54643-7886 INJECTION, SOLUTION 1.40 mg INTRAVENOUS NDA 14 sections
Pediatric Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 12 54643-7898 KIT 1.40 mg None NDA 14 sections
Adult Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 12 54643-9007 INJECTION, SOLUTION 3.60 mg INTRAVENOUS NDA 14 sections
Adult Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 12 54643-9015 INJECTION, SOLUTION 3.60 mg INTRAVENOUS NDA 14 sections
Pediatric Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 12 54643-9023 INJECTION, SOLUTION 1.40 mg INTRAVENOUS NDA 14 sections
Pediatric Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 12 54643-9031 KIT 1.40 mg None NDA 14 sections
Multi-Vitamin with Fluoride HUMAN PRESCRIPTION DRUG LABEL 9 58657-325 LIQUID 0.60 mg ORAL unapproved drug other 10 sections
Multi-Vitamin with Fluoride HUMAN PRESCRIPTION DRUG LABEL 9 58657-326 LIQUID 0.60 mg ORAL unapproved drug other 10 sections
Multi-Vitamin Drops with Fluoride and Iron HUMAN PRESCRIPTION DRUG LABEL 9 58657-327 LIQUID 0.60 mg ORAL unapproved drug other 10 sections
M.V.I. Pediatric HUMAN PRESCRIPTION DRUG LABEL 12 61703-421 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1.40 mg INTRAVENOUS NDA 16 sections
M.V.I. Adult HUMAN PRESCRIPTION DRUG LABEL 12 61703-422 KIT 3.60 mg None NDA 14 sections
M.V.I. Adult HUMAN PRESCRIPTION DRUG LABEL 12 61703-434 KIT 3.60 mg None NDA 14 sections
Vitamin B Complex HUMAN PRESCRIPTION DRUG LABEL 4 67457-146 INJECTION 2 mg INTRAVENOUS Unapproved drug other 9 sections
Vitamin B Complex HUMAN PRESCRIPTION DRUG LABEL 5 69877-026 INJECTION, SOLUTION 2 mg INTRAMUSCULAR unapproved drug other 9 sections
VITAMIN B COMPLEX HUMAN PRESCRIPTION DRUG LABEL 5 71414-225 INJECTION 2 mg INTRAVENOUS unapproved drug other 8 sections