riboflavin phosphate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
2374 130-40-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • riboflavin sodium phosphate
  • RIBOFLAVIN 5'-PHOSPHATE SODIUM
  • riboflavin phosphate
  • vitamin B2 phosphate
  • riboflavin 5'-(dihydrogen phosphate)
  • flavin mononucleotide
A coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.
  • Molecular weight: 456.35
  • Formula: C17H21N4O9P
  • CLOGP: -2.60
  • LIPINSKI: 2
  • HAC: 13
  • HDO: 6
  • TPSA: 201.58
  • ALOGS: -2.83
  • ROTB: 7
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AURKC,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK4,CDK5,CDK9,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT1,FLT3,GRK2,GRK3,GSK3A,GSK3B,IGF1R,IKBKB,IRAK1,ITK,JAK1,JAK2,JAK3,KDR,KIT,MAP2K6,MAP3K14,MAP3K2,MAP3K21,MAP3K3,MAP3K7,MAP4K1,MAP4K3,MAPK1,MAPK10,MAPK12,MAPK7,MAPK8,MAPK9,MAPKAPK2,MARK4,MELK,MET,MTOR,NTRK1,NTRK2,PDK1,PDK2,PDK4,PIK3CA,PIK3CB,PIK3CD,PIM1,PIM2,PLK1,PLK2,PLK3,PLK4,PRKCD,PRKDC,PTK2,SGK1,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2,ZAP70 86
kinase-selectivity-class ACVR2B,AURKA,AXL,BRAF,CAMK2D,CDK1,CDK4,CDK9,DDR1,DYRK1B,EPHB4,ERBB2,GRK2,IRAK1,IRAK3,MAP2K6,MAP3K21,MAPK7,PIK3CD,PIK3CG,PRKDC,SIK2,STK33,SYK,TEK,ZAP70 26
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 1953 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Feeling abnormal 22.21 18.17 28 3080 167207 90458132
Calcitonin secretion disorder 19.66 18.17 3 3105 43 90625296

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Feeling abnormal 24.92 18.38 31 3802 180680 110404786
Calcitonin secretion disorder 19.62 18.38 3 3830 43 110585423
Off label use 18.53 18.38 15 3818 1500170 109085296

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
MeSH PA D018977 Micronutrients
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:66981 ophthalmology drug

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.57 acidic
pKa2 6.62 acidic
pKa3 10.13 acidic
pKa4 12.34 acidic
pKa5 13.19 acidic
pKa6 2.49 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
2 IU/ML;40MG/ML;12MCG/ML;40 IU/ML;1MCG/ML;3MG/ML;120MCG/ML;8MG/ML;1.2MG/ML;0.72MG/ML;1.2MG/ML;660 IU/ML;30MCG/ML MULTIPLE VITAMINS INJECTION ADULT APOTEX A210672 April 9, 2026 RX SOLUTION INTRAVENOUS Dec. 1, 2026 COMPETITIVE GENERIC THERAPY
EQ 0.239% BASE/ML;EQ 0.177% BASE/ML EPIOXA HD/EPIOXA KIT GLAUKOS N219910 Oct. 17, 2025 RX SOLUTION/DROPS OPHTHALMIC Oct. 17, 2028 NEW PRODUCT

Bioactivity Summary:

None

External reference:

IDSource
4017670 VUID
N0000178985 NUI
D01622 KEGG_DRUG
4017670 VANDF
4017770 VANDF
C0016388 UMLSCUI
FMN PDB_CHEM_ID
CHEMBL1201794 ChEMBL_ID
643976 PUBCHEM_CID
DB03247 DRUGBANK_ID
CHEMBL3989697 ChEMBL_ID
1925820 RXNORM
31895 MMSL
001060 NDDF
014666 NDDF
442346000 SNOMEDCT_US
53499005 SNOMEDCT_US
D005486 MESH_DESCRIPTOR_UI
CHEBI:32098 CHEBI
6184-17-4 SECONDARY_CAS_RN
5185 IUPHAR_LIGAND_ID
20RD1DZH99 UNII
7N464URE7E UNII
957E53WV42 UNII

Pharmaceutical products:

None