riboflavin phosphate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2374 130-40-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • riboflavin sodium phosphate
  • RIBOFLAVIN 5'-PHOSPHATE SODIUM
  • riboflavin phosphate
  • vitamin B2 phosphate
  • riboflavin 5'-(dihydrogen phosphate)
  • flavin mononucleotide
A coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.
  • Molecular weight: 456.35
  • Formula: C17H21N4O9P
  • CLOGP: -2.60
  • LIPINSKI: 2
  • HAC: 13
  • HDO: 6
  • TPSA: 201.58
  • ALOGS: -2.83
  • ROTB: 7

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 1953 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Corneal thinning 24.15 19.64 4 1974 109 63486935

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Corneal epithelium defect 109.50 24.63 17 912 362 34955640
Corneal infiltrates 107.56 24.63 15 914 146 34955856
Corneal opacity 102.09 24.63 17 912 569 34955433
Corneal scar 83.35 24.63 12 917 149 34955853
Ulcerative keratitis 43.93 24.63 10 919 1719 34954283
Corneal oedema 40.80 24.63 9 920 1342 34954660
Keratitis 40.16 24.63 9 920 1442 34954560
Corneal thinning 30.79 24.63 5 924 142 34955860

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Corneal infiltrates 101.59 19.42 16 2641 294 79741437
Corneal opacity 94.99 19.42 18 2639 1002 79740729
Corneal epithelium defect 62.65 19.42 12 2645 707 79741024
Corneal scar 58.85 19.42 10 2647 298 79741433
Corneal thinning 41.96 19.42 7 2650 186 79741545
Keratitis 32.57 19.42 10 2647 4312 79737419
Ulcerative keratitis 25.54 19.42 8 2649 3681 79738050
Corneal oedema 23.79 19.42 7 2650 2613 79739118

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D018977 Micronutrients
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
CHEBI has role CHEBI:23354 coenzymes
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.57 acidic
pKa2 6.62 acidic
pKa3 10.13 acidic
pKa4 12.34 acidic
pKa5 13.19 acidic
pKa6 2.49 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4017670 VUID
N0000178985 NUI
D01622 KEGG_DRUG
4017670 VANDF
4017770 VANDF
C0016388 UMLSCUI
CHEBI:32098 CHEBI
FMN PDB_CHEM_ID
CHEMBL1201794 ChEMBL_ID
643976 PUBCHEM_CID
DB03247 DRUGBANK_ID
CHEMBL3989697 ChEMBL_ID
5185 IUPHAR_LIGAND_ID
1925820 RXNORM
31895 MMSL
001060 NDDF
014666 NDDF
442346000 SNOMEDCT_US
53499005 SNOMEDCT_US
D005486 MESH_DESCRIPTOR_UI
6184-17-4 SECONDARY_CAS_RN
20RD1DZH99 UNII
7N464URE7E UNII
957E53WV42 UNII

Pharmaceutical products:

None