ribavirin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antivirals 2373 36791-04-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ribavirin
  • ribamide
  • ribamidil
  • ribavarin
  • tribavirin
A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.
  • Molecular weight: 244.21
  • Formula: C8H12N4O5
  • CLOGP: -2.57
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 4
  • TPSA: 143.72
  • ALOGS: -0.87
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
6 g Inhal.solution
1 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 142 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 17 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 35.10 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 14 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 5.20 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 1 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 45 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 31, 1985 FDA VALEANT PHARM INTL
Nov. 21, 2001 PMDA Schering-Plough

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaemia 3602.22 13.80 2695 61277 290735 63134315
Haemoglobin decreased 1076.30 13.80 1002 62970 144483 63280567
White blood cell count decreased 940.88 13.80 912 63060 138192 63286858
Hepatitis C 831.98 13.80 279 63693 4995 63420055
Platelet count decreased 793.60 13.80 766 63206 115356 63309694
Hepatocellular carcinoma 744.29 13.80 209 63763 1985 63423065
Neutrophil count decreased 461.94 13.80 412 63560 55994 63369056
Jaundice 378.08 13.80 279 63693 28972 63396078
Blood bilirubin increased 360.33 13.80 299 63673 36841 63388209
Ascites 358.45 13.80 310 63662 40418 63384632
Decreased appetite 352.34 13.80 779 63193 250273 63174777
Hyperbilirubinaemia 320.04 13.80 177 63795 11137 63413913
Rash 316.79 13.80 1257 62715 559614 62865436
Anal pruritus 312.66 13.80 82 63890 585 63424465
Hepatic encephalopathy 309.57 13.80 173 63799 11109 63413941
Dysgeusia 308.82 13.80 303 63669 46407 63378643
Influenza like illness 308.17 13.80 358 63614 66466 63358584
Hepatic failure 298.87 13.80 264 63708 35392 63389658
Haemolytic anaemia 290.79 13.80 160 63812 9965 63415085
Depression 285.98 13.80 619 63353 195873 63229177
Hepatic cirrhosis 282.17 13.80 219 63753 24515 63400535
Leukopenia 274.27 13.80 363 63609 76927 63348123
Nausea 268.95 13.80 1619 62353 852852 62572198
Anorectal discomfort 261.83 13.80 99 63873 2540 63422510
Asthenia 258.74 13.80 911 63061 382693 63042357
Viral load increased 250.04 13.80 81 63891 1293 63423757
Fatigue 239.39 13.80 1618 62354 886410 62538640
Retinopathy 225.24 13.80 93 63879 3026 63422024
Pruritus 210.53 13.80 819 63153 360634 63064416
Red blood cell count decreased 209.86 13.80 231 63741 40414 63384636
Insomnia 209.43 13.80 581 63391 214671 63210379
Pancytopenia 202.62 13.80 356 63616 96577 63328473
Joint swelling 200.16 13.80 43 63929 327623 63097427
Drug hypersensitivity 199.79 13.80 36 63936 310651 63114399
Contraindicated product administered 192.07 13.80 6 63966 217642 63207408
Thrombocytopenia 181.88 13.80 442 63530 150715 63274335
Drug intolerance 175.74 13.80 47 63925 308614 63116436
Hyperuricaemia 171.31 13.80 91 63881 5279 63419771
Arthropathy 167.54 13.80 20 63952 234772 63190278
Product use issue 161.83 13.80 17 63955 220503 63204547
Therapeutic product effect decreased 161.40 13.80 8 63964 193179 63231871
Vomiting 157.98 13.80 1033 62939 558584 62866466
Rheumatoid arthritis 155.57 13.80 33 63939 253786 63171264
Off label use 150.80 13.80 282 63690 674180 62750870
Wound 149.70 13.80 3 63969 163260 63261790
Systemic lupus erythematosus 148.53 13.80 18 63954 208900 63216150
Hepatitis C RNA increased 141.05 13.80 32 63940 111 63424939
Hepatitis C RNA positive 140.85 13.80 28 63944 39 63425011
Toxicity to various agents 136.31 13.80 40 63932 247210 63177840
Peripheral swelling 131.07 13.80 52 63920 265890 63159160
Proctalgia 128.80 13.80 79 63893 6031 63419019
Hypersensitivity 126.09 13.80 69 63903 292616 63132434
Pyrexia 125.06 13.80 856 63116 469622 62955428
Condition aggravated 119.17 13.80 138 63834 402079 63022971
Completed suicide 118.63 13.80 7 63965 145666 63279384
Neutropenia 116.98 13.80 415 63557 174590 63250460
Chills 116.01 13.80 312 63660 113066 63311984
Cryoglobulinaemia 111.58 13.80 34 63938 439 63424611
Autoimmune hepatitis 109.51 13.80 81 63891 8429 63416621
Vogt-Koyanagi-Harada disease 101.58 13.80 25 63947 133 63424917
COVID-19 100.15 13.80 3 63969 113100 63311950
Irritability 98.94 13.80 140 63832 31554 63393496
Dry skin 98.78 13.80 193 63779 56694 63368356
Weight decreased 96.89 13.80 541 63431 276257 63148793
Pain 95.89 13.80 403 63569 740225 62684825
Swelling 92.20 13.80 85 63887 275293 63149757
Nasopharyngitis 91.81 13.80 73 63899 254184 63170866
Product use in unapproved indication 91.55 13.80 33 63939 179047 63246003
Hyperthyroidism 91.03 13.80 92 63880 14581 63410469
Hepatic enzyme increased 89.58 13.80 46 63926 202282 63222768
Infection 87.62 13.80 62 63910 229111 63195939
Oesophageal varices haemorrhage 86.42 13.80 36 63936 1198 63423852
Retinal exudates 86.30 13.80 31 63941 685 63424365
Musculoskeletal stiffness 81.68 13.80 42 63930 184576 63240474
Porphyria non-acute 81.53 13.80 24 63948 273 63424777
Pericarditis 80.77 13.80 17 63955 131562 63293488
Discomfort 80.34 13.80 34 63938 167340 63257710
Hepatic cancer 79.55 13.80 52 63920 4435 63420615
Portal vein thrombosis 79.49 13.80 43 63929 2587 63422463
Sinusitis 79.42 13.80 67 63905 226586 63198464
Genotype drug resistance test positive 76.65 13.80 25 63947 408 63424642
Cutaneous sarcoidosis 76.52 13.80 24 63948 343 63424707
Abdominal discomfort 76.09 13.80 129 63843 320756 63104294
Glossodynia 75.76 13.80 43 63929 178833 63246217
Therapeutic product effect incomplete 75.05 13.80 17 63955 125039 63300011
Hepatitis B reactivation 75.04 13.80 44 63928 3093 63421957
Maternal exposure during pregnancy 74.74 13.80 67 63905 219995 63205055
Haemorrhoids 73.85 13.80 101 63871 22049 63403001
Intentional product use issue 73.59 13.80 19 63953 127873 63297177
Psoriatic arthropathy 72.70 13.80 5 63967 91515 63333535
Impaired healing 72.43 13.80 9 63963 102533 63322517
Retinal haemorrhage 72.40 13.80 51 63921 4918 63420132
Blood cholesterol increased 72.25 13.80 6 63966 94026 63331024
Virologic failure 72.24 13.80 36 63936 1826 63423224
Dehydration 70.98 13.80 354 63618 173000 63252050
Drug ineffective 70.58 13.80 694 63278 1044071 62380979
Malignant neoplasm progression 69.84 13.80 3 63969 82118 63342932
Rheumatoid factor positive 68.87 13.80 4 63968 84402 63340648
Fall 68.67 13.80 187 63785 392147 63032903
Helicobacter infection 68.41 13.80 7 63965 92778 63332272
Arthralgia 66.96 13.80 321 63651 569389 62855661
Mobility decreased 65.98 13.80 20 63952 121139 63303911
Renal impairment 64.60 13.80 216 63756 88139 63336911
Sarcoidosis 62.18 13.80 54 63918 7068 63417982
Varices oesophageal 62.04 13.80 39 63933 3109 63421941
Erythema multiforme 61.69 13.80 63 63909 10106 63414944
Osteoarthritis 61.29 13.80 11 63961 95332 63329718
Lower respiratory tract infection 60.16 13.80 29 63943 132278 63292772
Blood uric acid increased 60.05 13.80 47 63925 5320 63419730
Death 58.59 13.80 188 63784 374193 63050857
Headache 58.35 13.80 928 63044 632313 62792737
Disease progression 57.21 13.80 26 63946 122732 63302318
Irritable bowel syndrome 56.36 13.80 8 63964 82404 63342646
Transfusion 56.27 13.80 73 63899 15144 63409906
Hypertension 55.17 13.80 125 63847 279178 63145872
Anger 54.47 13.80 65 63907 12391 63412659
Oxygen saturation decreased 53.23 13.80 12 63960 88573 63336477
Malaise 52.58 13.80 645 63327 415309 63009741
Drug eruption 51.81 13.80 99 63873 28595 63396455
Autoimmune thyroiditis 51.42 13.80 38 63934 3948 63421102
Toxic skin eruption 49.51 13.80 63 63909 12822 63412228
Peritonitis bacterial 48.78 13.80 40 63932 4839 63420211
Drug reaction with eosinophilia and systemic symptoms 48.37 13.80 106 63866 33730 63391320
Basedow's disease 47.19 13.80 16 63956 296 63424754
Exposure via body fluid 46.63 13.80 19 63953 597 63424453
Weight increased 46.56 13.80 123 63849 260669 63164381
Loss of personal independence in daily activities 46.29 13.80 20 63952 97270 63327780
Exposure via father 45.31 13.80 15 63957 257 63424793
Liver transplant rejection 44.87 13.80 24 63948 1411 63423639
Injection site pain 44.66 13.80 39 63933 129761 63295289
Liver transplant 44.19 13.80 28 63944 2263 63422787
Injury 43.85 13.80 10 63962 73237 63351813
Myalgia 43.19 13.80 274 63698 146255 63278795
Hepatic cancer recurrent 42.76 13.80 10 63962 41 63425009
C-reactive protein increased 42.68 13.80 21 63951 94686 63330364
Intentional overdose 42.67 13.80 11 63961 74141 63350909
Exposure via direct contact 42.16 13.80 12 63960 120 63424930
Wheezing 41.88 13.80 22 63950 95573 63329477
Depressive symptom 41.79 13.80 34 63938 4068 63420982
Hypothyroidism 41.24 13.80 115 63857 42517 63382533
Arthritis 40.90 13.80 34 63938 115887 63309163
Hepatorenal syndrome 40.77 13.80 25 63947 1907 63423143
Rash pruritic 40.04 13.80 142 63830 59657 63365393
Liver injury 38.85 13.80 7 63965 60513 63364537
Hepatic fibrosis 38.75 13.80 31 63941 3621 63421429
Pain in extremity 38.71 13.80 187 63785 331299 63093751
Tongue pigmentation 38.44 13.80 8 63964 16 63425034
Exposure via partner 38.04 13.80 11 63961 117 63424933
Urticaria 38.02 13.80 68 63904 165734 63259316
Child-Pugh-Turcotte score increased 37.80 13.80 8 63964 18 63425032
Yellow skin 36.98 13.80 25 63947 2255 63422795
Face oedema 36.81 13.80 70 63902 20142 63404908
Gastrointestinal disorder 36.68 13.80 47 63925 131192 63293858
Bilirubin conjugated increased 36.52 13.80 27 63945 2807 63422243
Dry mouth 36.18 13.80 165 63807 77698 63347352
Ammonia increased 36.07 13.80 33 63939 4623 63420427
Drug abuse 35.96 13.80 14 63958 72504 63352546
Type 2 diabetes mellitus 35.76 13.80 10 63962 63858 63361192
Febrile neutropenia 35.67 13.80 40 63932 118409 63306641
Type 1 diabetes mellitus 35.66 13.80 30 63942 3760 63421290
Blood pressure fluctuation 35.45 13.80 3 63969 46314 63378736
Encephalopathy 35.24 13.80 102 63870 38518 63386532
Hospitalisation 35.22 13.80 21 63951 85060 63339990
Hepatitis C virus test positive 35.13 13.80 10 63962 100 63424950
Intentional product misuse 35.12 13.80 9 63963 60908 63364142
Flushing 33.30 13.80 17 63955 75070 63349980
Angiotensin converting enzyme increased 33.30 13.80 9 63963 73 63424977
Haemolysis 32.40 13.80 37 63935 6731 63418319
Viral mutation identified 32.14 13.80 21 63951 1789 63423261
Nasal congestion 32.03 13.80 13 63959 65647 63359403
Mood swings 31.76 13.80 62 63910 18186 63406864
Ill-defined disorder 31.36 13.80 22 63950 81733 63343317
Thirst 31.16 13.80 53 63919 13988 63411062
Paternal drugs affecting foetus 31.01 13.80 8 63964 53 63424997
Aplastic anaemia 30.94 13.80 43 63929 9526 63415524
Blood pressure increased 30.79 13.80 74 63898 161988 63263062
Ocular icterus 30.47 13.80 27 63945 3629 63421421
Injection site rash 30.45 13.80 62 63910 18747 63406303
Renal failure 30.43 13.80 213 63759 117439 63307611
Fibromyalgia 30.38 13.80 22 63950 80398 63344652
Anorectal disorder 30.35 13.80 20 63952 1729 63423321
Pregnancy of partner 29.50 13.80 7 63965 31 63425019
Urate nephropathy 29.41 13.80 9 63963 118 63424932
Disturbance in attention 29.36 13.80 95 63877 38094 63386956
Blood pressure systolic increased 29.33 13.80 6 63966 47391 63377659
Inflammation 29.18 13.80 24 63948 82249 63342801
Complications of transplanted liver 28.98 13.80 12 63960 393 63424657
Alanine aminotransferase increased 28.70 13.80 191 63781 103579 63321471
Osteoporosis 28.55 13.80 11 63961 57327 63367723
Thyroiditis 28.47 13.80 22 63950 2444 63422606
Aplasia pure red cell 27.58 13.80 28 63944 4459 63420591
Glomerulonephritis 27.39 13.80 19 63953 1787 63423263
Adverse drug reaction 27.35 13.80 24 63948 79690 63345360
Splenomegaly 27.29 13.80 44 63928 11113 63413937
Alcoholism 27.28 13.80 19 63953 1799 63423251
Electrocardiogram QT prolonged 27.12 13.80 13 63959 59517 63365533
Rash papular 26.91 13.80 53 63919 15649 63409401
Liver transplant failure 26.19 13.80 6 63966 22 63425028
Haematocrit decreased 25.97 13.80 93 63879 39247 63385803
Suicidal ideation 25.88 13.80 128 63844 62293 63362757
Hypersplenism 25.83 13.80 10 63962 274 63424776
Hypotension 25.68 13.80 165 63807 272439 63152611
Crying 25.63 13.80 66 63906 23277 63401773
Hepatitis C virus test 25.57 13.80 5 63967 6 63425044
Anaphylactic reaction 25.07 13.80 18 63954 66082 63358968
Glomerulonephritis membranoproliferative 24.72 13.80 9 63963 207 63424843
Gait disturbance 24.59 13.80 98 63874 183080 63241970
Bursitis 24.40 13.80 4 63968 37037 63388013
Aspartate aminotransferase increased 24.26 13.80 165 63807 90112 63334938
Neuropathy peripheral 23.96 13.80 49 63923 113618 63311432
Hepatitis E 23.82 13.80 16 63956 1428 63423622
Pancreas transplant rejection 23.75 13.80 8 63964 145 63424905
Contusion 23.65 13.80 75 63897 149969 63275081
Disease recurrence 23.64 13.80 72 63900 27958 63397092
Emotional disorder 22.73 13.80 45 63927 13334 63411716
Feeling cold 22.67 13.80 64 63908 23824 63401226
Joint range of motion decreased 22.52 13.80 3 63969 32425 63392625
Erythema nodosum 22.24 13.80 26 63946 4849 63420201
Extradural abscess 22.04 13.80 13 63959 924 63424126
Epistaxis 22.03 13.80 137 63835 72588 63352462
Oral mucosal blistering 21.98 13.80 28 63944 5705 63419345
Subarachnoid haemorrhage 21.85 13.80 46 63926 14237 63410813
Muscular weakness 21.58 13.80 58 63914 122295 63302755
Hypophagia 21.58 13.80 75 63897 31184 63393866
Skin disorder 21.43 13.80 72 63900 29435 63395615
Syncope 21.32 13.80 196 63776 117189 63307861
Chromaturia 21.25 13.80 50 63922 16667 63408383
Full blood count abnormal 20.95 13.80 75 63897 31642 63393408
Hepatic hydrothorax 20.92 13.80 5 63967 23 63425027
Viral load decreased 20.41 13.80 5 63967 26 63425024
Mental disorder 20.40 13.80 65 63907 25854 63399196
Coronary artery disease 20.24 13.80 4 63968 32373 63392677
Cardiac failure congestive 20.21 13.80 39 63933 92394 63332656
Facial paralysis 20.08 13.80 44 63928 13997 63411053
Pulmonary embolism 20.07 13.80 56 63916 116628 63308422
Hepatorenal failure 20.01 13.80 11 63961 683 63424367
Blood disorder 19.79 13.80 29 63943 6742 63418308
Dermatitis 19.72 13.80 49 63923 16909 63408141
Retinal detachment 19.56 13.80 27 63945 5942 63419108
Sleep apnoea syndrome 19.52 13.80 3 63969 29130 63395920
Hepatitis cholestatic 19.44 13.80 29 63943 6849 63418201
Cardiac arrest 19.42 13.80 40 63932 92505 63332545
Surgery 19.41 13.80 6 63966 35906 63389144
Memory impairment 19.40 13.80 175 63797 104083 63320967
Inappropriate schedule of product administration 19.32 13.80 48 63924 103917 63321133
Abortion induced 19.31 13.80 36 63936 10206 63414844
Paraesthesia 19.20 13.80 87 63885 156879 63268171
Serotonin syndrome 19.11 13.80 3 63969 28679 63396371
Anti-erythropoietin antibody positive 19.06 13.80 9 63963 405 63424645
Overgrowth fungal 18.80 13.80 6 63966 91 63424959
Blood potassium decreased 18.73 13.80 88 63884 41938 63383112
Gingival bleeding 18.63 13.80 40 63932 12547 63412503
Liver function test increased 18.62 13.80 5 63967 32806 63392244
Maternal exposure before pregnancy 18.62 13.80 30 63942 7573 63417477
Hepatitis B 18.52 13.80 21 63951 3791 63421259
Blister 18.35 13.80 68 63904 129746 63295304
Guillain-Barre syndrome 18.16 13.80 21 63951 3872 63421178
Disseminated intravascular coagulation 18.04 13.80 51 63921 19000 63406050
Red blood cell sedimentation rate increased 18.00 13.80 11 63961 43971 63381079
Asthma 17.91 13.80 67 63905 127494 63297556
Lethargy 17.91 13.80 107 63865 55900 63369150
Depressed mood 17.80 13.80 84 63888 40107 63384943
Rhinorrhoea 17.78 13.80 24 63948 65553 63359497
Hashitoxicosis 17.70 13.80 3 63969 0 63425050
Miscarriage of partner 17.70 13.80 3 63969 0 63425050
Hepatitis C RNA decreased 17.70 13.80 3 63969 0 63425050
Hepatitis virus-associated nephropathy 17.70 13.80 3 63969 0 63425050
Chronic kidney disease 17.70 13.80 12 63960 45386 63379664
Pain in jaw 17.63 13.80 11 63961 43485 63381565
Chest discomfort 17.31 13.80 55 63917 109914 63315136
Retinal disorder 17.20 13.80 14 63958 1676 63423374
Hepatopulmonary syndrome 17.18 13.80 4 63968 16 63425034
Paranoia 17.16 13.80 37 63935 11642 63413408
Ocular sarcoidosis 17.14 13.80 5 63967 55 63424995
Product prescribing error 16.96 13.80 3 63969 26286 63398764
Deep vein thrombosis 16.93 13.80 37 63935 83763 63341287
Portal hypertension 16.81 13.80 20 63952 3799 63421251
Hypervolaemia 16.76 13.80 4 63968 28409 63396641
Blood bilirubin unconjugated increased 16.66 13.80 8 63964 374 63424676
Therapy non-responder 16.55 13.80 132 63840 75769 63349281
Blood albumin decreased 16.47 13.80 42 63930 14724 63410326
VIIIth nerve lesion 16.46 13.80 4 63968 20 63425030
Intentional self-injury 16.42 13.80 3 63969 25684 63399366
Joint stiffness 16.41 13.80 11 63961 41858 63383192
Sciatica 16.41 13.80 7 63965 34317 63390733
Immune thrombocytopenia 16.15 13.80 34 63938 10522 63414528
Plasma cell myeloma 16.11 13.80 8 63964 35897 63389153
Constipation 16.05 13.80 147 63825 224796 63200254
Gastric varices haemorrhage 16.01 13.80 6 63966 150 63424900
Cerebral arteriovenous malformation haemorrhagic 15.63 13.80 3 63969 3 63425047
Hepatic neoplasm 15.54 13.80 14 63958 1922 63423128
Injection site swelling 15.52 13.80 15 63957 47557 63377493
Psoriasis 15.50 13.80 41 63931 86916 63338134
Psychotic disorder 15.47 13.80 59 63913 25653 63399397
Congenital tongue anomaly 15.17 13.80 3 63969 4 63425046
Upper respiratory tract infection 15.15 13.80 38 63934 82009 63343041
Bleeding varicose vein 15.12 13.80 7 63965 301 63424749
Visual acuity reduced 14.75 13.80 52 63920 21774 63403276
Lymphocyte count decreased 14.74 13.80 6 63966 30251 63394799
Device issue 14.73 13.80 3 63969 23778 63401272
Anaphylactic shock 14.60 13.80 3 63969 23630 63401420
Obesity 14.49 13.80 6 63966 29946 63395104
Clostridium difficile infection 14.47 13.80 6 63966 29916 63395134
Bronchopulmonary disease 14.41 13.80 3 63969 6 63425044
Oedema due to hepatic disease 14.41 13.80 3 63969 6 63425044
Therapy responder 14.40 13.80 7 63965 336 63424714
Live birth 14.37 13.80 4 63968 25626 63399424
Disorientation 14.34 13.80 78 63894 39374 63385676
Limb discomfort 14.30 13.80 6 63966 29710 63395340
Hemiparesis 14.29 13.80 3 63969 23279 63401771
Joint injury 14.19 13.80 6 63966 29566 63395484
Blood creatinine increased 14.13 13.80 143 63829 87701 63337349
Cheilitis 14.08 13.80 19 63953 4094 63420956
Pathogen resistance 14.00 13.80 24 63948 6374 63418676
Nervousness 13.90 13.80 65 63907 30914 63394136
Blood bilirubin abnormal 13.90 13.80 10 63962 997 63424053
Hepatic function abnormal 13.88 13.80 74 63898 37068 63387982
Lung disorder 13.84 13.80 26 63946 62235 63362815
Non-neutralising antibodies positive 13.81 13.80 3 63969 8 63425042

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaemia 2514.21 12.42 2946 81831 230389 34641765
Hepatitis C 1870.42 12.42 752 84025 9078 34863076
Hepatocellular carcinoma 1842.45 12.42 691 84086 6818 34865336
Rash 989.00 12.42 1859 82918 220893 34651261
White blood cell count decreased 742.90 12.42 1030 83747 94415 34777739
Fatigue 713.07 12.42 2238 82539 368415 34503739
Hepatic cirrhosis 701.02 12.42 467 84310 16847 34855307
Haemoglobin decreased 676.48 12.42 1118 83659 119654 34752500
Influenza like illness 583.05 12.42 505 84272 27129 34845025
Pruritus 517.16 12.42 1093 83684 140888 34731266
Treatment failure 508.38 12.42 596 84181 46101 34826053
Ascites 479.92 12.42 578 84199 45993 34826161
Insomnia 458.53 12.42 867 83910 103040 34769114
Platelet count decreased 440.74 12.42 926 83851 118791 34753363
Hepatic encephalopathy 436.37 12.42 328 84449 14357 34857797
Blood bilirubin increased 413.76 12.42 487 84290 37809 34834345
Genotype drug resistance test positive 407.82 12.42 139 84638 1006 34871148
Depression 403.52 12.42 790 83987 96308 34775846
Anorectal discomfort 372.35 12.42 150 84627 1814 34870340
Retinopathy 351.59 12.42 146 84631 1918 34870236
Anal pruritus 338.07 12.42 93 84684 283 34871871
Hepatic failure 330.40 12.42 413 84364 34118 34838036
Dysgeusia 323.39 12.42 359 84418 26138 34846016
Irritability 309.06 12.42 339 84438 24351 34847803
Neutrophil count decreased 286.50 12.42 474 84303 50630 34821524
Hyperbilirubinaemia 284.86 12.42 272 84505 16571 34855583
Toxicity to various agents 279.38 12.42 71 84706 200291 34671863
Death 277.09 12.42 336 84441 397713 34474441
Liver transplant 276.03 12.42 131 84646 2403 34869751
Jaundice 273.07 12.42 361 84416 31521 34840633
Hepatic cancer 264.11 12.42 193 84584 8082 34864072
Hyperuricaemia 262.18 12.42 190 84587 7853 34864301
Headache 246.07 12.42 1050 83727 199585 34672569
Oesophageal varices haemorrhage 237.86 12.42 127 84650 3019 34869135
Viral load increased 231.32 12.42 116 84661 2411 34869743
Decreased appetite 224.50 12.42 897 83880 165495 34706659
Virologic failure 204.41 12.42 119 84658 3361 34868793
Nausea 198.41 12.42 1455 83322 338453 34533701
Febrile neutropenia 195.47 12.42 46 84731 136803 34735351
Leukopenia 192.26 12.42 452 84325 62404 34809750
Malignant neoplasm progression 182.86 12.42 7 84770 88039 34784115
Hepatitis C RNA positive 169.20 12.42 46 84731 132 34872022
Off label use 164.53 12.42 499 84278 419025 34453129
Hypotension 163.58 12.42 178 84599 221471 34650683
Drug abuse 161.31 12.42 24 84753 99072 34773082
Hepatitis C RNA increased 158.84 12.42 49 84728 246 34871908
Retinal exudates 154.64 12.42 61 84716 695 34871459
Disease progression 138.09 12.42 45 84732 108032 34764122
Proctalgia 133.72 12.42 111 84666 5612 34866542
Fall 132.62 12.42 179 84598 202706 34669448
Haemolytic anaemia 131.27 12.42 144 84633 10335 34861819
Product use in unapproved indication 125.66 12.42 64 84713 117435 34754719
Peritonitis bacterial 123.38 12.42 109 84668 6001 34866153
Varices oesophageal 118.49 12.42 87 84690 3668 34868486
Haemorrhoids 115.52 12.42 159 84618 14416 34857738
Completed suicide 115.04 12.42 47 84730 98121 34774033
Infusion related reaction 114.49 12.42 3 84774 53054 34819100
Mood swings 113.90 12.42 117 84660 7784 34864370
Dry skin 113.56 12.42 241 84536 31046 34841108
Porphyria non-acute 109.02 12.42 42 84735 447 34871707
Red blood cell count decreased 107.81 12.42 226 84551 28864 34843290
Drug hypersensitivity 105.57 12.42 32 84745 80497 34791657
Depressed mood 105.23 12.42 177 84600 19140 34853014
Pancytopenia 104.14 12.42 482 84295 94675 34777479
Viral mutation identified 103.65 12.42 73 84704 2881 34869273
Hepatic cancer recurrent 102.59 12.42 36 84741 287 34871867
Cardiac failure congestive 98.97 12.42 39 84738 83231 34788923
Cryoglobulinaemia 97.60 12.42 38 84739 417 34871737
Acute kidney injury 95.69 12.42 398 84379 304590 34567564
Asthenia 92.29 12.42 954 83823 244297 34627857
Thrombocytopenia 91.86 12.42 671 84106 155576 34716578
Oxygen saturation decreased 89.96 12.42 12 84765 53806 34818348
Retinal haemorrhage 89.47 12.42 84 84693 5005 34867149
Rash pruritic 89.20 12.42 200 84577 26741 34845413
Drug eruption 84.96 12.42 164 84613 19734 34852420
Weight decreased 84.88 12.42 723 84054 175578 34696576
Blood pressure increased 80.18 12.42 58 84719 88044 34784110
Vogt-Koyanagi-Harada disease 79.47 12.42 22 84755 69 34872085
Hepatorenal syndrome 77.93 12.42 59 84718 2607 34869547
Injection site rash 77.75 12.42 71 84706 4082 34868072
Portal hypertension 77.14 12.42 70 84707 3992 34868162
Therapeutic product effect incomplete 76.13 12.42 15 84762 50526 34821628
Atrial fibrillation 75.87 12.42 112 84665 122281 34749873
Erythema multiforme 74.09 12.42 98 84679 8551 34863603
Plasma cell myeloma 73.64 12.42 8 84769 42029 34830125
Hepatic hydrothorax 73.62 12.42 18 84759 28 34872126
Hepatitis C virus test positive 73.54 12.42 29 84748 330 34871824
Renal impairment 72.53 12.42 434 84343 94079 34778075
Hospitalisation 72.09 12.42 24 84753 56878 34815276
Intentional product misuse 72.02 12.42 12 84765 45599 34826555
General physical health deterioration 71.41 12.42 126 84651 128143 34744011
Mucosal inflammation 71.22 12.42 6 84771 38616 34833538
Condition aggravated 71.18 12.42 234 84543 191962 34680192
Drug ineffective 69.68 12.42 1520 83257 455231 34416923
Portal vein thrombosis 69.44 12.42 64 84713 3724 34868430
Electrocardiogram QT prolonged 66.41 12.42 10 84767 40942 34831212
Intentional product use issue 66.30 12.42 31 84746 59785 34812369
Prostate cancer 65.88 12.42 9 84768 39640 34832514
Pneumonia 63.71 12.42 568 84209 362059 34510095
Haemolysis 63.68 12.42 88 84689 8006 34864148
Peripheral swelling 62.62 12.42 56 84721 76485 34795669
Hepatitis B reactivation 62.30 12.42 61 84716 3830 34868324
Injection site erythema 61.80 12.42 126 84651 15773 34856381
Anger 60.90 12.42 106 84671 11778 34860376
Weight increased 58.75 12.42 84 84693 92949 34779205
Bradycardia 58.38 12.42 58 84719 75360 34796794
Liver transplant rejection 57.79 12.42 45 84732 2074 34870080
Tachycardia 57.11 12.42 73 84704 84699 34787455
Myocardial infarction 56.26 12.42 132 84645 120953 34751201
Intentional overdose 56.06 12.42 18 84759 43656 34828498
Suicidal ideation 55.25 12.42 219 84558 40169 34831985
Coronary artery disease 55.15 12.42 24 84753 48281 34823873
Hypertension 53.37 12.42 162 84615 136281 34735873
Cardiac arrest 53.00 12.42 95 84682 96064 34776090
Hyperkalaemia 52.98 12.42 54 84723 69335 34802819
Hepatitis C RNA 52.51 12.42 12 84765 11 34872143
Foetal exposure during pregnancy 52.02 12.42 14 84763 38087 34834067
C-reactive protein increased 51.34 12.42 34 84743 54064 34818090
Therapy non-responder 50.15 12.42 208 84569 38938 34833216
Flushing 50.15 12.42 9 84768 32411 34839743
Blood pressure fluctuation 46.34 12.42 4 84773 25245 34846909
Hepatic pain 46.29 12.42 34 84743 1434 34870720
Asthma 45.90 12.42 23 84754 42633 34829521
Blood uric acid increased 45.66 12.42 83 84694 9541 34862613
Hypoxia 45.42 12.42 40 84737 55055 34817099
Malaise 45.06 12.42 666 84111 185159 34686995
Heart rate decreased 44.61 12.42 11 84766 31734 34840420
Blood bilirubin unconjugated increased 43.99 12.42 24 84753 596 34871558
Anaphylactic reaction 43.85 12.42 12 84765 32289 34839865
Respiratory failure 43.82 12.42 127 84650 108445 34763709
Rheumatoid arthritis 43.65 12.42 19 84758 38219 34833935
Cardio-respiratory arrest 43.36 12.42 42 84735 55231 34816923
Gastric varices haemorrhage 43.09 12.42 18 84759 240 34871914
Pneumonia aspiration 43.02 12.42 24 84753 41879 34830275
Neuropathy peripheral 42.60 12.42 86 84691 83177 34788977
Cardiogenic shock 42.02 12.42 7 84770 26611 34845543
Bleeding varicose vein 41.44 12.42 19 84758 321 34871833
Yellow skin 41.14 12.42 37 84740 2085 34870069
Pregnancy of partner 41.12 12.42 19 84758 327 34871827
Child-Pugh-Turcotte score increased 41.12 12.42 10 84767 15 34872139
Encephalopathy 40.88 12.42 182 84595 35137 34837017
Pulmonary embolism 40.74 12.42 99 84678 89647 34782507
Wheezing 40.68 12.42 25 84752 41377 34830777
Focal segmental glomerulosclerosis 40.63 12.42 36 84741 1989 34870165
Viral load 39.97 12.42 12 84765 54 34872100
Joint swelling 39.88 12.42 52 84725 59838 34812316
Basedow's disease 39.79 12.42 12 84765 55 34872099
Hyponatraemia 38.50 12.42 90 84687 82601 34789553
Therapeutic product effect decreased 38.50 12.42 18 84759 34725 34837429
Contraindicated product administered 37.84 12.42 4 84773 21477 34850677
Skin disorder 37.66 12.42 94 84683 13461 34858693
Hypersensitivity 37.64 12.42 56 84721 60979 34811175
Dry mouth 37.63 12.42 159 84618 30006 34842148
Facial paralysis 37.00 12.42 81 84696 10653 34861501
Sedation 36.78 12.42 4 84773 21002 34851152
Wrong technique in product usage process 36.38 12.42 21 84756 35965 34836189
Angioedema 36.12 12.42 23 84754 37351 34834803
Vomiting 35.93 12.42 819 83958 246802 34625352
Cardiac failure 35.89 12.42 108 84669 91140 34781014
Myalgia 35.78 12.42 336 84441 83774 34788380
Alopecia 35.69 12.42 135 84642 24220 34847934
Chronic obstructive pulmonary disease 35.19 12.42 40 84737 48878 34823276
Disturbance in attention 34.13 12.42 139 84638 25806 34846348
Product prescribing error 34.11 12.42 7 84770 22920 34849234
Pyrexia 34.08 12.42 1052 83725 331961 34540193
Glomerulonephritis membranoproliferative 33.70 12.42 18 84759 428 34871726
Cerebrovascular accident 33.63 12.42 100 84677 84711 34787443
Affect lability 33.52 12.42 43 84734 3640 34868514
Sarcoidosis 33.27 12.42 38 84739 2850 34869304
Mental disorder 32.73 12.42 96 84681 15113 34857041
Hepatitis C RNA fluctuation 32.68 12.42 7 84770 3 34872151
Mood altered 32.51 12.42 69 84708 8883 34863271
Neuroleptic malignant syndrome 32.48 12.42 3 84774 17931 34854223
Cardiac disorder 32.41 12.42 34 84743 43092 34829062
Osteonecrosis of jaw 32.38 12.42 3 84774 17886 34854268
Constipation 32.37 12.42 197 84580 136785 34735369
Biliary colic 32.15 12.42 24 84753 1038 34871116
Optic ischaemic neuropathy 32.14 12.42 32 84745 2050 34870104
Ocular icterus 31.92 12.42 37 84740 2820 34869334
Chronic hepatitis C 31.68 12.42 17 84760 408 34871746
Musculoskeletal stiffness 31.63 12.42 40 84737 46640 34825514
Drug reaction with eosinophilia and systemic symptoms 31.58 12.42 161 84616 32851 34839303
Pneumocystis jirovecii pneumonia 31.52 12.42 5 84772 19705 34852449
Neutropenia 31.24 12.42 544 84233 156234 34715920
Hypoglycaemia 30.98 12.42 53 84724 54587 34817567
Hepatitis C virus test 30.93 12.42 10 84767 60 34872094
Product use issue 30.89 12.42 67 84710 63149 34809005
Acute on chronic liver failure 30.68 12.42 11 84766 94 34872060
Muscular weakness 30.33 12.42 84 84693 72813 34799341
Injection site ulcer 29.93 12.42 14 84763 248 34871906
Transfusion 29.83 12.42 65 84712 8520 34863634
Clostridium difficile infection 29.76 12.42 5 84772 18893 34853261
Chills 29.74 12.42 314 84463 80729 34791425
Arthropathy 29.72 12.42 14 84763 26893 34845261
Bilirubin conjugated increased 29.47 12.42 38 84739 3233 34868921
Renal disorder 29.26 12.42 131 84646 25349 34846805
Ammonia increased 29.25 12.42 44 84733 4325 34867829
Blood cholesterol increased 29.09 12.42 7 84770 20536 34851618
Pain in extremity 28.82 12.42 184 84593 126329 34745825
Retinal detachment 28.82 12.42 49 84728 5342 34866812
Alopecia universalis 28.56 12.42 11 84766 117 34872037
Haematuria 27.99 12.42 49 84728 50017 34822137
Psoriatic arthropathy 27.55 12.42 7 84770 19791 34852363
Hepatic fibrosis 27.49 12.42 44 84733 4563 34867591
Therapeutic embolisation 27.23 12.42 14 84763 307 34871847
Homicidal ideation 27.10 12.42 33 84744 2649 34869505
Injection site reaction 26.85 12.42 81 84696 12952 34859202
Ventricular fibrillation 26.84 12.42 11 84766 22943 34849211
Psychotic disorder 26.80 12.42 124 84653 24328 34847826
Gastrointestinal haemorrhage 26.67 12.42 117 84660 88360 34783794
Anorectal disorder 26.53 12.42 22 84755 1110 34871044
Hypocalcaemia 26.28 12.42 13 84764 24276 34847878
Pulmonary oedema 26.13 12.42 47 84730 47482 34824672
Lethargy 26.06 12.42 180 84597 40942 34831212
Metabolic acidosis 26.04 12.42 41 84736 43639 34828515
Rhabdomyolysis 25.86 12.42 82 84695 68081 34804073
Labelled drug-drug interaction medication error 25.76 12.42 3 84774 14936 34857218
Blood pressure decreased 25.67 12.42 54 84723 51461 34820693
COVID-19 pneumonia 25.62 12.42 5 84772 16962 34855192
Testicular germ cell tumour mixed 25.52 12.42 7 84770 21 34872133
Exposure via body fluid 25.42 12.42 10 84767 113 34872041
Heart rate irregular 25.30 12.42 4 84773 15803 34856351
Acute stress disorder 25.11 12.42 11 84766 166 34871988
Alanine aminotransferase increased 25.07 12.42 303 84474 80512 34791642
Sleep apnoea syndrome 24.99 12.42 9 84768 20312 34851842
Genital herpes simplex 24.96 12.42 10 84767 119 34872035
Sepsis 24.88 12.42 271 84506 166290 34705864
Complications of transplanted liver 24.75 12.42 12 84765 231 34871923
Coma hepatic 24.65 12.42 15 84762 460 34871694
Product quality issue 24.61 12.42 94 84683 16941 34855213
Injection site pruritus 24.41 12.42 53 84724 6930 34865224
Ejection fraction decreased 24.39 12.42 8 84769 19146 34853008
Device related infection 24.16 12.42 6 84771 17231 34854923
Neurotoxicity 23.87 12.42 7 84770 18003 34854151
Synovitis 23.83 12.42 3 84774 14063 34858091
Blood pressure systolic increased 23.77 12.42 13 84764 22939 34849215
Alpha 1 foetoprotein increased 23.72 12.42 17 84760 690 34871464
Orthostatic hypotension 23.64 12.42 17 84760 25902 34846252
Respiratory arrest 23.55 12.42 20 84757 28023 34844131
Ventricular tachycardia 23.51 12.42 18 84759 26561 34845593
Thrombosis 23.41 12.42 55 84722 50403 34821751
Type 1 diabetes mellitus 23.16 12.42 39 84738 4219 34867935
Depressed level of consciousness 22.98 12.42 43 84734 42798 34829356
Hepatic neoplasm 22.75 12.42 26 84751 1951 34870203
Upper respiratory tract infection 22.73 12.42 28 84749 33031 34839123
Acute myeloid leukaemia 22.62 12.42 8 84769 18262 34853892
Acute respiratory failure 22.55 12.42 25 84752 30903 34841251
Exposure via direct contact 22.55 12.42 7 84770 36 34872118
Haemophilic arthropathy 22.53 12.42 10 84767 156 34871998
Porphyria 22.39 12.42 7 84770 37 34872117
Mobility decreased 22.36 12.42 24 84753 30104 34842050
Ammonia abnormal 22.25 12.42 8 84769 69 34872085
Somnolence 22.16 12.42 168 84609 110948 34761206
Basal cell carcinoma 22.07 12.42 10 84767 19648 34852506
Injection site pain 21.96 12.42 38 84739 38967 34833187
Emotional disorder 21.86 12.42 45 84732 5671 34866483
Toxic skin eruption 21.82 12.42 69 84708 11316 34860838
Normal newborn 21.81 12.42 10 84767 169 34871985
Herpes zoster 21.75 12.42 31 84746 34368 34837786
Urinary retention 21.69 12.42 34 84743 36254 34835900
Inappropriate schedule of product administration 21.55 12.42 78 84699 62218 34809936
Acute myocardial infarction 21.53 12.42 63 84714 53656 34818498
Toxic epidermal necrolysis 21.36 12.42 13 84764 21633 34850521
Asterixis 21.00 12.42 20 84757 1213 34870941
Osteoarthritis 20.93 12.42 12 84765 20630 34851524
International normalised ratio increased 20.85 12.42 53 84724 47274 34824880
Facial paresis 20.83 12.42 31 84746 3018 34869136
Nasopharyngitis 20.80 12.42 93 84684 69875 34802279
Genital herpes 20.69 12.42 15 84762 620 34871534
Liver disorder 20.65 12.42 144 84633 32853 34839301
Liver transplant failure 20.29 12.42 8 84769 91 34872063
Fat intolerance 20.10 12.42 4 84773 0 34872154
Pregnancy 20.10 12.42 11 84766 275 34871879
Autoimmune hepatitis 19.92 12.42 37 84740 4323 34867831
Eczema 19.84 12.42 93 84684 18343 34853811
Poisoning 19.78 12.42 3 84774 12223 34859931
Diverticulitis 19.76 12.42 12 84765 19992 34852162
Cholelithiasis 19.43 12.42 102 84675 21046 34851108
Memory impairment 19.39 12.42 175 84602 43143 34829011
Productive cough 19.38 12.42 39 84738 37774 34834380
Mitochondrial toxicity 19.24 12.42 28 84749 2671 34869483
Haematemesis 19.18 12.42 124 84653 27587 34844567
Urticaria 19.09 12.42 82 84695 62295 34809859
Premature baby 19.08 12.42 12 84765 19621 34852533
Chest discomfort 19.04 12.42 68 84709 54462 34817692
Photophobia 19.03 12.42 48 84729 6916 34865238
Loss of personal independence in daily activities 18.97 12.42 32 84745 33147 34839007
Tubulointerstitial nephritis 18.90 12.42 14 84763 21010 34851144
Diabetic hyperglycaemic coma 18.85 12.42 6 84771 34 34872120
Drug ineffective for unapproved indication 18.61 12.42 18 84759 23697 34848457
Anticoagulation drug level below therapeutic 18.56 12.42 16 84761 852 34871302
Seizure 18.41 12.42 164 84613 104693 34767461
Pleural effusion 18.36 12.42 119 84658 81427 34790727
Photosensitivity reaction 18.32 12.42 62 84715 10532 34861622
Blood iron increased 18.27 12.42 16 84761 870 34871284
Alpha 1 foetoprotein abnormal 18.23 12.42 5 84772 15 34872139
Feeling cold 18.17 12.42 62 84715 10577 34861577
Squamous cell carcinoma 18.15 12.42 3 84774 11472 34860682
Palmar-plantar erythrodysaesthesia syndrome 18.15 12.42 9 84768 16786 34855368
Oral herpes 18.15 12.42 41 84736 5506 34866648
Respiratory distress 18.09 12.42 37 84740 35628 34836526
Oral lichen planus 18.08 12.42 9 84768 184 34871970
Anaphylactic shock 18.06 12.42 8 84769 15933 34856221
Paraesthesia 18.06 12.42 87 84690 64085 34808069
Ischaemic stroke 17.95 12.42 11 84766 18239 34853915
Bacterascites 17.87 12.42 4 84773 3 34872151
Hypomagnesaemia 17.84 12.42 16 84761 21835 34850319
Thought blocking 17.67 12.42 8 84769 131 34872023
Adrenal insufficiency 17.65 12.42 6 84771 14041 34858113
Hepatic lesion 17.59 12.42 32 84745 3680 34868474
Sopor 17.45 12.42 4 84773 12132 34860022
Pneumonitis 17.31 12.42 35 84742 33843 34838311
Blood disorder 17.29 12.42 30 84747 3324 34868830
Intestinal obstruction 17.14 12.42 18 84759 22804 34849350
Sudden visual loss 17.12 12.42 5 84772 20 34872134
Neutropenic sepsis 17.09 12.42 6 84771 13761 34858393
Feeling abnormal 17.02 12.42 231 84546 63004 34809150
Hip fracture 17.01 12.42 4 84773 11921 34860233
Myelodysplastic syndrome 17.00 12.42 13 84764 19195 34852959
Sinusitis 17.00 12.42 48 84729 41354 34830800
Hyperlipidaemia 16.93 12.42 7 84770 14522 34857632
Tachypnoea 16.78 12.42 12 84765 18340 34853814
Abortion spontaneous 16.68 12.42 11 84766 389 34871765
Cutaneous sarcoidosis 16.65 12.42 8 84769 151 34872003
Overdose 16.61 12.42 141 84636 90918 34781236
Coma 16.59 12.42 56 84721 45622 34826532
Pulmonary tuberculosis 16.52 12.42 36 84741 4718 34867436
Circulatory collapse 16.47 12.42 16 84761 21022 34851132
Optic neuropathy 16.42 12.42 22 84755 1943 34870211
Portal hypertensive gastropathy 16.42 12.42 13 84764 614 34871540
Nasal congestion 16.42 12.42 19 84758 23038 34849116
Deafness congenital 16.39 12.42 7 84770 99 34872055
Angina pectoris 16.37 12.42 32 84745 31331 34840823
Prescribed overdose 16.37 12.42 3 84774 10644 34861510
Papilloedema 16.31 12.42 26 84751 2687 34869467
Thirst 16.20 12.42 49 84728 7846 34864308
Incorrect route of product administration 15.97 12.42 8 84769 14837 34857317
Mouth ulceration 15.81 12.42 64 84713 11846 34860308
Injection site necrosis 15.71 12.42 11 84766 430 34871724
Nephritic syndrome 15.65 12.42 6 84771 63 34872091
Body temperature decreased 15.64 12.42 6 84771 13028 34859126
Skin cancer 15.62 12.42 3 84774 10294 34861860
Therapy responder 15.58 12.42 8 84769 175 34871979
Hepatic amoebiasis 15.56 12.42 6 84771 64 34872090
Inflammation 15.53 12.42 28 84749 28267 34843887
Injection site dermatitis 15.40 12.42 4 84773 9 34872145
Hepatitis E 15.40 12.42 22 84755 2064 34870090
Extrapyramidal disorder 15.34 12.42 6 84771 12874 34859280
Gastric varices 15.28 12.42 12 84765 560 34871594
Limb discomfort 15.19 12.42 4 84773 11043 34861111
Haemorrhoidal haemorrhage 15.12 12.42 30 84747 3681 34868473
Viral load undetectable 15.07 12.42 3 84774 0 34872154
Anxiety 15.03 12.42 331 84446 99097 34773057
Status epilepticus 14.82 12.42 6 84771 12608 34859546
Wrong dose 14.79 12.42 12 84765 587 34871567
Skin irritation 14.78 12.42 38 84739 5539 34866615
Rales 14.74 12.42 3 84774 9880 34862274
Mitral valve incompetence 14.71 12.42 9 84768 14934 34857220
Nephrotic syndrome 14.68 12.42 45 84732 7258 34864896
Chronic kidney disease 14.65 12.42 51 84726 41159 34830995
Procalcitonin 14.58 12.42 4 84773 12 34872142
Bronchiectasis 14.56 12.42 3 84774 9798 34862356
Borderline personality disorder 14.53 12.42 10 84767 380 34871774
Bladder cancer 14.43 12.42 11 84766 16267 34855887
Dyskinesia 14.37 12.42 20 84757 22393 34849761
Ear injury 14.34 12.42 5 84772 39 34872115
Fundoscopy abnormal 14.34 12.42 4 84773 13 34872141
Respiratory tract infection 14.30 12.42 16 84761 19696 34852458
Oesophageal variceal ligation 14.30 12.42 6 84771 81 34872073
Hypervolaemia 14.29 12.42 16 84761 19693 34852461
Anti-erythropoietin antibody positive 14.27 12.42 14 84763 881 34871273
Aspergillus infection 14.12 12.42 6 84771 12248 34859906
Aspartate aminotransferase increased 14.12 12.42 237 84540 67546 34804608
Vision blurred 14.10 12.42 172 84605 45791 34826363
Retinal vein thrombosis 14.03 12.42 10 84767 402 34871752
Hepatitis chronic active 14.02 12.42 5 84772 42 34872112
Chromaturia 14.01 12.42 71 84706 14449 34857705
Hot flush 13.85 12.42 14 84763 18052 34854102
Fungal infection 13.83 12.42 11 84766 15924 34856230
Gene mutation identification test positive 13.72 12.42 7 84770 151 34872003
Oedema due to hepatic disease 13.70 12.42 4 84773 16 34872138
Unresponsive to stimuli 13.65 12.42 29 84748 27540 34844614
Disease recurrence 13.57 12.42 94 84683 21396 34850758
Bronchitis 13.56 12.42 54 84723 41909 34830245
Emotional distress 13.51 12.42 10 84767 15016 34857138
Fibrosis 13.49 12.42 23 84754 2513 34869641
Aplasia pure red cell 13.48 12.42 39 84738 6093 34866061
Clostridium difficile colitis 13.47 12.42 11 84766 15719 34856435
Sudden hearing loss 13.47 12.42 14 84763 944 34871210
Hallucination, visual 13.39 12.42 14 84763 17777 34854377
Tongue ulceration 13.38 12.42 16 84761 1260 34870894
Drug intolerance 13.37 12.42 87 84690 59483 34812671
Alcoholism 13.35 12.42 25 84752 2940 34869214
Hepatopulmonary syndrome 13.32 12.42 4 84773 18 34872136
Neutralising antibodies positive 13.27 12.42 6 84771 98 34872056
Colitis 13.23 12.42 47 84730 37703 34834451
Infection 13.13 12.42 149 84628 90766 34781388
Blood pressure diastolic decreased 13.07 12.42 3 84774 9091 34863063
Left ventricular dysfunction 13.06 12.42 4 84773 10003 34862151
Hypercatabolism 13.00 12.42 3 84774 3 34872151
Transaminases decreased 13.00 12.42 3 84774 3 34872151
Delusional disorder, erotomanic type 13.00 12.42 3 84774 3 34872151
Infective spondylitis 12.98 12.42 8 84769 251 34871903
Drug level increased 12.92 12.42 21 84756 22075 34850079
Gait disturbance 12.90 12.42 138 84639 85002 34787152
Glossodynia 12.87 12.42 28 84749 3665 34868489
Bronchopulmonary aspergillosis 12.87 12.42 10 84767 14649 34857505
Hydrocholecystis 12.86 12.42 10 84767 460 34871694
Drug interaction 12.85 12.42 434 84343 225512 34646642
Bronchospasm 12.78 12.42 5 84772 10726 34861428
Myopathy 12.78 12.42 6 84771 11548 34860606
Lymphocyte count decreased 12.77 12.42 22 84755 22600 34849554
Decubitus ulcer 12.71 12.42 3 84774 8918 34863236
Rhinorrhoea 12.70 12.42 27 84750 25641 34846513
Stress 12.59 12.42 35 84742 30312 34841842
Hepatic cytolysis 12.59 12.42 10 84767 14486 34857668
Benign prostatic hyperplasia 12.59 12.42 10 84767 14485 34857669
Haematochezia 12.57 12.42 64 84713 46470 34825684
CD4 lymphocyte percentage decreased 12.54 12.42 3 84774 4 34872150
Neoplasm malignant 12.52 12.42 18 84759 19887 34852267
Remission not achieved 12.50 12.42 6 84771 113 34872041
Urinary tract infection 12.45 12.42 137 84640 83944 34788210

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaemia 5224.38 11.53 4707 114892 440308 79184481
Hepatocellular carcinoma 2484.00 11.53 801 118798 8220 79616569
Hepatitis C 2476.11 11.53 856 118743 11069 79613720
Haemoglobin decreased 1496.22 11.53 1751 117848 220368 79404421
White blood cell count decreased 1424.86 11.53 1577 118022 186711 79438078
Platelet count decreased 1117.13 11.53 1416 118183 193248 79431541
Hepatic cirrhosis 854.02 11.53 574 119025 34332 79590457
Ascites 847.58 11.53 784 118815 74778 79550011
Rash 813.02 11.53 2294 117305 576064 79048725
Neutrophil count decreased 782.93 11.53 829 118770 93130 79531659
Blood bilirubin increased 736.53 11.53 684 118915 65548 79559241
Hepatic encephalopathy 692.89 11.53 439 119160 23727 79601062
Hyperbilirubinaemia 640.31 11.53 420 119179 24098 79600691
Fatigue 632.04 11.53 2906 116693 926821 78697968
Jaundice 628.23 11.53 569 119030 52780 79572009
Hepatic failure 585.65 11.53 582 119017 60630 79564159
Retinopathy 566.45 11.53 215 119384 3676 79621113
Insomnia 561.67 11.53 1176 118423 243994 79380795
Influenza like illness 559.03 11.53 611 118988 71096 79553693
Depression 523.66 11.53 1063 118536 215727 79409062
Hyperuricaemia 494.68 11.53 274 119325 11525 79613264
Decreased appetite 476.16 11.53 1355 118244 341063 79283726
Pruritus 466.99 11.53 1475 118124 393173 79231616
Anal pruritus 452.24 11.53 124 119475 677 79624112
Leukopenia 440.39 11.53 695 118904 115818 79508971
Genotype drug resistance test positive 400.50 11.53 126 119473 1182 79623607
Dysgeusia 367.45 11.53 441 119158 56736 79568053
Anorectal discomfort 367.05 11.53 154 119445 3457 79621332
Toxicity to various agents 356.48 11.53 96 119503 421444 79203345
Irritability 347.66 11.53 366 119233 40778 79584011
Oesophageal varices haemorrhage 346.59 11.53 155 119444 4081 79620708
Haemolytic anaemia 344.87 11.53 254 119345 17566 79607223
Hepatic cancer 341.61 11.53 207 119392 10322 79614467
Infusion related reaction 328.56 11.53 3 119596 230234 79394555
Viral load increased 320.81 11.53 132 119467 2816 79621973
Pancytopenia 310.30 11.53 734 118865 165011 79459778
Drug hypersensitivity 291.51 11.53 49 119550 298867 79325922
Thrombocytopenia 289.27 11.53 965 118634 264294 79360495
Hepatitis C RNA positive 280.04 11.53 67 119532 186 79624603
Liver transplant 260.53 11.53 129 119470 4294 79620495
Nausea 257.92 11.53 2371 117228 954825 78669964
Virologic failure 252.12 11.53 124 119475 4067 79620722
Asthenia 242.00 11.53 1450 118149 510239 79114550
Joint swelling 235.92 11.53 70 119529 288576 79336213
Completed suicide 225.23 11.53 47 119552 245720 79379069
Off label use 213.74 11.53 676 118923 906539 78718250
Proctalgia 212.78 11.53 151 119448 9850 79614939
COVID-19 212.42 11.53 5 119594 157669 79467120
Hepatitis C RNA increased 210.05 11.53 59 119540 357 79624432
Renal impairment 208.66 11.53 614 118985 157169 79467620
Contraindicated product administered 204.86 11.53 7 119592 157531 79467258
Synovitis 202.22 11.53 5 119594 150729 79474060
Arthropathy 194.15 11.53 20 119579 177091 79447698
Cryoglobulinaemia 193.13 11.53 65 119534 768 79624021
Fall 190.20 11.53 273 119326 487356 79137433
Varices oesophageal 189.76 11.53 116 119483 5875 79618914
Retinal exudates 189.76 11.53 71 119528 1164 79623625
Rheumatoid arthritis 186.65 11.53 42 119557 208428 79416361
Peripheral swelling 182.59 11.53 88 119511 269529 79355260
Dry skin 180.16 11.53 347 119252 67648 79557141
Hypersensitivity 175.44 11.53 87 119512 262152 79362637
Retinal haemorrhage 172.36 11.53 123 119476 8094 79616695
Vogt-Koyanagi-Harada disease 171.01 11.53 45 119554 204 79624585
Peritonitis bacterial 170.91 11.53 130 119469 9437 79615352
Porphyria non-acute 167.96 11.53 57 119542 692 79624097
Malignant neoplasm progression 167.03 11.53 9 119590 135981 79488808
Red blood cell count decreased 166.67 11.53 305 119294 57208 79567581
Condition aggravated 161.71 11.53 317 119282 500807 79123982
Therapeutic product effect decreased 161.56 11.53 26 119573 163837 79460952
Drug abuse 157.76 11.53 27 119572 162664 79462125
Febrile neutropenia 153.95 11.53 77 119522 230922 79393867
Hepatic cancer recurrent 152.30 11.53 42 119557 235 79624554
Drug intolerance 150.74 11.53 106 119493 264013 79360776
Product use in unapproved indication 150.25 11.53 95 119504 250264 79374525
Portal vein thrombosis 150.08 11.53 99 119500 5728 79619061
Death 148.40 11.53 401 119198 566113 79058676
Hepatitis B reactivation 148.22 11.53 100 119499 6008 79618781
Erythema multiforme 147.25 11.53 156 119443 17495 79607294
Drug eruption 144.09 11.53 246 119353 43689 79581100
Hypotension 141.60 11.53 279 119320 440038 79184751
Hand deformity 141.10 11.53 3 119596 103916 79520873
Haemorrhoids 140.50 11.53 195 119404 28933 79595856
Pain 137.81 11.53 566 119033 703236 78921553
Product use issue 135.27 11.53 73 119526 209749 79415040
Treatment failure 131.97 11.53 556 119043 169930 79454859
Viral mutation identified 130.71 11.53 78 119521 3780 79621009
Therapeutic product effect incomplete 129.88 11.53 27 119572 141618 79483171
Neutropenia 128.44 11.53 804 118795 286906 79337883
Oxygen saturation decreased 128.27 11.53 20 119579 129027 79495762
Wound 127.61 11.53 13 119586 116166 79508623
Disease progression 126.56 11.53 59 119540 184303 79440486
Headache 124.57 11.53 1512 118087 652260 78972529
Musculoskeletal stiffness 121.70 11.53 55 119544 174953 79449836
Hepatorenal syndrome 121.26 11.53 77 119522 4172 79620617
Intentional product use issue 113.52 11.53 43 119556 152069 79472720
Weight increased 111.27 11.53 152 119447 277234 79347555
Liver transplant rejection 110.90 11.53 66 119533 3182 79621607
Pyrexia 110.06 11.53 1524 118075 677185 78947604
Nasopharyngitis 106.04 11.53 135 119464 253746 79371043
Systemic lupus erythematosus 105.25 11.53 26 119573 121123 79503666
Blood pressure increased 101.82 11.53 100 119499 211260 79413529
Autoimmune hepatitis 101.60 11.53 106 119493 11677 79613112
Portal hypertension 98.02 11.53 83 119516 7025 79617764
Maternal exposure during pregnancy 97.95 11.53 41 119558 136497 79488292
Weight decreased 95.94 11.53 882 118717 354316 79270473
Sinusitis 94.74 11.53 92 119507 195409 79429380
Hepatic hydrothorax 93.33 11.53 22 119577 56 79624733
Mood swings 91.28 11.53 130 119469 19750 79605039
Intentional product misuse 89.62 11.53 17 119582 95148 79529641
Basedow's disease 88.01 11.53 27 119572 231 79624558
Blood cholesterol increased 87.83 11.53 11 119588 83709 79541080
Depressed mood 87.66 11.53 212 119387 48268 79576521
Anger 87.45 11.53 118 119481 17044 79607745
Cutaneous sarcoidosis 86.81 11.53 31 119568 442 79624347
Intentional overdose 85.92 11.53 26 119573 105934 79518855
Blood uric acid increased 85.69 11.53 103 119496 13257 79611532
Hypertension 85.22 11.53 236 119363 330756 79294033
Mobility decreased 83.98 11.53 39 119560 122136 79502653
Swelling 83.65 11.53 122 119477 216589 79408200
Cardiac failure congestive 82.71 11.53 56 119543 142346 79482443
Psoriatic arthropathy 82.44 11.53 10 119589 77989 79546800
Wheezing 82.13 11.53 36 119563 116628 79508161
Blood pressure fluctuation 77.82 11.53 6 119593 67139 79557650
Electrocardiogram QT prolonged 77.34 11.53 20 119579 90366 79534423
C-reactive protein increased 77.30 11.53 49 119550 128978 79495811
Osteoarthritis 77.28 11.53 18 119581 87291 79537498
Flushing 76.55 11.53 19 119580 88249 79536540
Duodenal ulcer perforation 76.50 11.53 6 119593 66205 79558584
Helicobacter infection 76.02 11.53 8 119591 69696 79555093
Vomiting 75.41 11.53 1409 118190 664419 78960370
Infection 75.15 11.53 156 119443 241556 79383233
Yellow skin 74.74 11.53 53 119546 3452 79621337
Hepatic enzyme increased 74.27 11.53 99 119500 182511 79442278
Pain in extremity 72.49 11.53 291 119308 364247 79260542
Chills 72.15 11.53 449 119150 159785 79465004
Child-Pugh-Turcotte score increased 71.92 11.53 16 119583 28 79624761
Glomerulonephritis membranoproliferative 71.56 11.53 29 119570 594 79624195
Injection site pain 71.55 11.53 54 119545 129784 79495005
Arthralgia 71.53 11.53 533 119066 571270 79053519
Haemolysis 71.32 11.53 92 119507 12720 79612069
Rheumatoid factor positive 70.34 11.53 5 119594 59834 79564955
Encephalopathy 68.69 11.53 240 119359 67157 79557632
Toxic skin eruption 66.81 11.53 120 119479 22173 79602616
Discomfort 65.76 11.53 55 119544 125562 79499227
Suicidal ideation 65.38 11.53 257 119342 76083 79548706
Rash pruritic 65.32 11.53 246 119353 71383 79553406
Sedation 65.09 11.53 3 119596 51892 79572897
Urticaria 65.07 11.53 111 119488 185090 79439699
Sarcoidosis 64.84 11.53 71 119528 8264 79616525
Hospitalisation 63.35 11.53 31 119568 94205 79530584
Bilirubin conjugated increased 63.03 11.53 58 119541 5481 79619308
Anaphylactic reaction 61.92 11.53 24 119575 83719 79541070
Alanine aminotransferase increased 60.80 11.53 435 119164 162135 79462654
Arthritis 60.50 11.53 50 119549 114830 79509959
C-reactive protein abnormal 60.00 11.53 3 119596 48364 79576425
Renal disorder 59.58 11.53 168 119431 41937 79582852
Asthma 59.36 11.53 69 119530 135026 79489763
Injury 59.33 11.53 21 119578 77475 79547314
Myalgia 58.94 11.53 478 119121 185163 79439626
Mucosal inflammation 58.69 11.53 20 119579 75560 79549229
Facial paralysis 57.58 11.53 109 119490 20963 79603826
Type 1 diabetes mellitus 57.44 11.53 61 119538 6858 79617931
Hepatitis C virus test 57.36 11.53 15 119584 66 79624723
Muscle injury 57.24 11.53 4 119595 48557 79576232
Blood pressure systolic increased 56.97 11.53 15 119584 66971 79557818
Complications of transplanted liver 56.91 11.53 22 119577 396 79624393
Loss of personal independence in daily activities 56.08 11.53 43 119556 102537 79522252
Gastric varices haemorrhage 55.62 11.53 22 119577 422 79624367
Psychotic disorder 55.49 11.53 162 119437 41240 79583549
Autoimmune thyroiditis 55.46 11.53 48 119551 4185 79620604
Irritable bowel syndrome 54.75 11.53 13 119586 62228 79562561
Glossodynia 54.38 11.53 45 119554 103292 79521497
Ocular icterus 53.85 11.53 53 119546 5447 79619342
Hyperthyroidism 53.56 11.53 109 119490 22100 79602689
Pericarditis 52.90 11.53 47 119552 104189 79520600
Knee arthroplasty 52.66 11.53 3 119596 43245 79581544
Optic ischaemic neuropathy 52.37 11.53 40 119559 2921 79621868
Disturbance in attention 51.85 11.53 181 119418 50620 79574169
Lower respiratory tract infection 51.57 11.53 71 119528 129149 79495640
Lethargy 51.51 11.53 250 119349 81042 79543747
Hepatic fibrosis 51.47 11.53 59 119540 7221 79617568
Nasal congestion 50.23 11.53 26 119573 76526 79548263
Hepatitis C virus test positive 49.93 11.53 20 119579 397 79624392
Hepatitis C RNA 49.91 11.53 11 119588 18 79624771
Serotonin syndrome 49.53 11.53 5 119594 45022 79579767
Cardiac arrest 49.42 11.53 116 119483 171980 79452809
Injection site rash 49.22 11.53 93 119506 17861 79606928
Ammonia increased 49.19 11.53 59 119540 7576 79617213
Impaired healing 47.59 11.53 37 119562 87618 79537171
Malaise 47.09 11.53 1012 118587 488857 79135932
Plasma cell myeloma 47.09 11.53 11 119588 53248 79571541
Aplasia pure red cell 46.51 11.53 58 119541 7752 79617037
Liver transplant failure 46.35 11.53 14 119585 113 79624676
Retinal detachment 46.23 11.53 63 119536 9184 79615605
Folliculitis 45.97 11.53 13 119586 55367 79569422
Heart rate decreased 45.96 11.53 24 119575 70292 79554497
Neuropathy peripheral 45.77 11.53 89 119510 141216 79483573
Prescribed overdose 45.01 11.53 3 119596 37880 79586909
General physical health deterioration 44.42 11.53 237 119362 275001 79349788
Pulmonary embolism 44.41 11.53 122 119477 171532 79453257
Splenomegaly 44.40 11.53 97 119502 20657 79604132
Chronic hepatitis C 44.35 11.53 21 119578 632 79624157
Focal segmental glomerulosclerosis 44.20 11.53 38 119561 3283 79621506
Depressive symptom 43.64 11.53 51 119548 6372 79618417
Fibromyalgia 43.50 11.53 21 119578 64319 79560470
Coronary artery disease 43.31 11.53 22 119577 65452 79559337
Gait disturbance 42.24 11.53 164 119435 207342 79417447
Contusion 42.14 11.53 101 119498 148675 79476114
Alopecia universalis 41.70 11.53 16 119583 282 79624507
Hepatic neoplasm 41.19 11.53 37 119562 3389 79621400
Aspartate aminotransferase increased 40.79 11.53 351 119248 138290 79486499
Blood bilirubin unconjugated increased 40.52 11.53 23 119576 1014 79623775
Alcoholism 40.46 11.53 38 119561 3685 79621104
Transfusion 40.41 11.53 95 119504 21235 79603554
Product prescribing error 40.13 11.53 9 119590 44804 79579985
Inappropriate schedule of product administration 40.04 11.53 88 119511 133540 79491249
Pregnancy of partner 39.86 11.53 15 119584 250 79624539
Upper respiratory tract infection 39.58 11.53 47 119552 91121 79533668
Ill-defined disorder 39.47 11.53 25 119574 65850 79558939
Hip arthroplasty 39.25 11.53 4 119595 35752 79589037
Osteoporosis 39.19 11.53 16 119583 54096 79570693
Hypoxia 38.95 11.53 59 119540 103184 79521605
Angiotensin converting enzyme increased 38.59 11.53 13 119586 154 79624635
Muscular weakness 38.12 11.53 119 119480 160610 79464179
Paraesthesia 38.08 11.53 136 119463 176187 79448602
Inflammation 37.92 11.53 51 119548 93702 79531087
Abdominal discomfort 37.67 11.53 221 119378 250506 79374283
Therapy non-responder 37.44 11.53 252 119347 92053 79532736
Clostridium difficile infection 37.37 11.53 9 119590 42676 79582113
Tachycardia 37.15 11.53 139 119460 177629 79447160
Therapeutic embolisation 36.71 11.53 17 119582 486 79624303
Angioedema 36.55 11.53 36 119563 75999 79548790
Anorectal disorder 36.27 11.53 29 119570 2264 79622525
Eczema 36.23 11.53 139 119460 40679 79584110
Nephrotic syndrome 35.88 11.53 62 119537 11112 79613677
Chest discomfort 35.79 11.53 98 119501 137946 79486843
Skin disorder 35.56 11.53 122 119477 33821 79590968
Pneumonia aspiration 35.43 11.53 29 119570 66938 79557851
Hepatitis E 35.41 11.53 32 119567 2954 79621835
Basal cell carcinoma 34.50 11.53 7 119592 37368 79587421
Drug reaction with eosinophilia and systemic symptoms 34.05 11.53 188 119411 64056 79560733
Injection site ulcer 33.75 11.53 18 119581 701 79624088
Blood creatinine increased 33.53 11.53 368 119231 154689 79470100
Myocardial infarction 33.46 11.53 152 119447 183977 79440812
Sleep apnoea syndrome 33.33 11.53 7 119592 36471 79588318
Bradycardia 33.11 11.53 99 119500 135458 79489331
Sopor 33.05 11.53 5 119594 33005 79591784
Cardiogenic shock 32.70 11.53 11 119588 41903 79582886
Mood altered 32.20 11.53 78 119521 17769 79607020
Atrial fibrillation 32.13 11.53 170 119429 197716 79427073
Somnolence 31.61 11.53 219 119380 238762 79386027
Homicidal ideation 31.43 11.53 32 119567 3425 79621364
Cerebrovascular accident 31.43 11.53 123 119476 155169 79469620
Pain in jaw 31.29 11.53 15 119584 46136 79578653
Cardio-respiratory arrest 31.25 11.53 73 119526 108437 79516352
Viral load 30.82 11.53 8 119591 34 79624755
Labelled drug-drug interaction medication error 30.60 11.53 3 119596 27647 79597142
Hepatitis C RNA fluctuation 30.60 11.53 6 119593 3 79624786
Respiratory depression 30.57 11.53 3 119596 27627 79597162
Device related infection 30.48 11.53 7 119592 34287 79590502
Neuroleptic malignant syndrome 30.47 11.53 3 119596 27556 79597233
Tongue pigmentation 30.45 11.53 8 119591 36 79624753
Pneumocystis jirovecii pneumonia 30.19 11.53 6 119593 32502 79592287
Acute respiratory failure 30.02 11.53 27 119572 59514 79565275
Throat irritation 29.83 11.53 12 119587 40934 79583855
Glomerulonephritis 29.80 11.53 31 119568 3402 79621387
Pulmonary tuberculosis 29.77 11.53 47 119552 7818 79616971
Testicular germ cell tumour mixed 29.64 11.53 7 119592 18 79624771
Diverticulitis 29.55 11.53 16 119583 45920 79578869
Pneumonia 29.34 11.53 760 118839 659486 78965303
Dermatitis 29.12 11.53 84 119515 21237 79603552
Exposure via body fluid 29.11 11.53 13 119586 341 79624448
Hyperkalaemia 29.07 11.53 82 119517 114316 79510473
Hepatopulmonary syndrome 28.97 11.53 8 119591 45 79624744
Acute kidney injury 28.67 11.53 578 119021 518826 79105963
Oedema due to hepatic disease 28.61 11.53 7 119592 22 79624767
Haematemesis 28.41 11.53 154 119445 52110 79572679
Pancreatitis acute 28.22 11.53 148 119451 49456 79575333
Rhinorrhoea 28.19 11.53 44 119555 76030 79548759
Respiratory arrest 27.95 11.53 27 119572 57523 79567266
Hip fracture 27.90 11.53 6 119593 30755 79594034
Orthostatic hypotension 27.69 11.53 26 119573 56138 79568651
Photosensitivity reaction 27.67 11.53 82 119517 21045 79603744
Hyponatraemia 27.65 11.53 155 119444 177693 79447096
Exposure during pregnancy 27.58 11.53 70 119529 101062 79523727
Dry mouth 27.56 11.53 226 119373 87793 79536996
COVID-19 pneumonia 27.48 11.53 5 119594 28844 79595945
Overdose 27.32 11.53 163 119436 184043 79440746
Prostate cancer 27.26 11.53 8 119591 33260 79591529
Gastrointestinal disorder 27.22 11.53 93 119506 122112 79502677
Coma 27.19 11.53 70 119529 100579 79524210
Emotional disorder 27.17 11.53 64 119535 14323 79610466
Sudden hearing loss 27.17 11.53 23 119576 1946 79622843
Hepatic pain 27.11 11.53 32 119567 4040 79620749
Emotional distress 27.08 11.53 13 119586 39956 79584833
Portal hypertensive gastropathy 27.00 11.53 20 119579 1394 79623395
Constipation 26.84 11.53 283 119316 282767 79342022
Limb discomfort 26.73 11.53 8 119591 32842 79591947
Bronchospasm 26.73 11.53 3 119596 24856 79599933
Visual acuity reduced 26.68 11.53 101 119498 29368 79595421
Surgery 26.63 11.53 8 119591 32758 79592031
Hypoglycaemia 26.42 11.53 72 119527 101522 79523267
Asterixis 26.34 11.53 26 119573 2681 79622108
Acute stress disorder 26.30 11.53 13 119586 431 79624358
Urate nephropathy 26.28 11.53 10 119589 172 79624617
Drug ineffective for unapproved indication 26.11 11.53 23 119576 51215 79573574
Liver injury 25.86 11.53 28 119571 56586 79568203
Chronic obstructive pulmonary disease 25.79 11.53 56 119543 85363 79539426
Herpes zoster 25.71 11.53 64 119535 93019 79531770
Affect lability 25.67 11.53 54 119545 11205 79613584
Chromaturia 25.64 11.53 91 119508 25655 79599134
Anti-erythropoietin antibody positive 25.61 11.53 15 119584 702 79624087
Joint range of motion decreased 25.51 11.53 9 119590 33273 79591516
Anaphylactic shock 25.50 11.53 11 119588 35985 79588804
Palmar-plantar erythrodysaesthesia syndrome 25.32 11.53 9 119590 33125 79591664
Wrong technique in product usage process 25.27 11.53 45 119554 73830 79550959
Blood pressure diastolic decreased 25.25 11.53 7 119592 30209 79594580
Device issue 25.18 11.53 5 119594 27103 79597686
Gastric varices 25.15 11.53 15 119584 726 79624063
Immune thrombocytopenia 25.14 11.53 71 119528 17734 79607055
Injection site dermatitis 24.73 11.53 6 119593 18 79624771
Biliary colic 24.52 11.53 30 119569 3932 79620857
Sudden visual loss 24.43 11.53 7 119592 46 79624743
Optic neuropathy 24.23 11.53 28 119571 3456 79621333
Incorrect route of product administration 24.23 11.53 11 119588 34918 79589871
Mental disorder 24.11 11.53 102 119497 31200 79593589
Alpha 1 foetoprotein increased 23.95 11.53 15 119584 793 79623996
Aplastic anaemia 23.93 11.53 70 119529 17835 79606954
Acute on chronic liver failure 23.90 11.53 11 119588 310 79624479
Oral lichen planus 23.65 11.53 15 119584 811 79623978
Erythema nodosum 23.28 11.53 34 119565 5283 79619506
Renal failure 23.21 11.53 427 119172 200541 79424248
Type 2 diabetes mellitus 23.17 11.53 31 119568 57091 79567698
Adverse drug reaction 23.11 11.53 40 119559 66352 79558437
Colitis 23.02 11.53 47 119552 73260 79551529
Injection site swelling 23.02 11.53 22 119577 47110 79577679
Musculoskeletal pain 22.72 11.53 78 119521 102276 79522513
Blood albumin decreased 22.71 11.53 84 119515 24159 79600630
Disease recurrence 22.66 11.53 128 119471 43981 79580808
Lung disorder 22.55 11.53 55 119544 80502 79544287
Bronchitis 22.46 11.53 110 119489 130534 79494255
Bursitis 22.31 11.53 13 119586 35831 79588958
Haemorrhoidal haemorrhage 22.21 11.53 38 119561 6757 79618032
Muscle spasticity 22.09 11.53 3 119596 21472 79603317
Genital herpes simplex 22.05 11.53 11 119588 372 79624417
Syncope 22.03 11.53 385 119214 179064 79445725
Lymphocyte count decreased 22.03 11.53 23 119576 47266 79577523
Hepatitis virus-associated nephropathy 22.02 11.53 4 119595 0 79624789
Hypervolaemia 21.95 11.53 19 119580 42671 79582118
Product quality issue 21.94 11.53 105 119494 33835 79590954
Retinal vein occlusion 21.94 11.53 26 119573 3297 79621492
Stress 21.79 11.53 55 119544 79557 79545232
Neutralising antibodies positive 21.75 11.53 10 119589 281 79624508
Rash papular 21.43 11.53 77 119522 21839 79602950
Neurotoxicity 21.39 11.53 11 119588 32507 79592282
Intervertebral discitis 21.33 11.53 31 119568 4797 79619992
Hypothyroidism 21.22 11.53 143 119456 52249 79572540
Joint stiffness 21.21 11.53 18 119581 40812 79583977
Body temperature decreased 20.96 11.53 11 119588 32134 79592655
Unresponsive to stimuli 20.92 11.53 32 119567 55756 79569033
Tendonitis 20.91 11.53 5 119594 23825 79600964
Poisoning 20.85 11.53 6 119593 25266 79599523
Ocular sarcoidosis 20.74 11.53 6 119593 41 79624748
Red blood cell sedimentation rate increased 20.68 11.53 23 119576 45919 79578870
Depressed level of consciousness 20.56 11.53 75 119524 96577 79528212
Blood disorder 20.42 11.53 41 119558 8232 79616557
Thought blocking 20.33 11.53 9 119590 231 79624558
Hepatitis cholestatic 20.31 11.53 56 119543 13796 79610993
Hypersplenism 20.21 11.53 12 119587 576 79624213
Gingival bleeding 20.21 11.53 62 119537 16214 79608575
Skin irritation 20.15 11.53 49 119550 11191 79613598
Obesity 20.13 11.53 14 119585 35111 79589678
Thrombosis 20.12 11.53 62 119537 84038 79540751
Lip swelling 20.09 11.53 19 119580 40892 79583897
Liver disorder 20.08 11.53 181 119418 72236 79552553
Procedural pain 19.95 11.53 5 119594 23079 79601710
Productive cough 19.82 11.53 67 119532 88264 79536525
Bleeding varicose vein 19.64 11.53 12 119587 607 79624182
Transaminases increased 19.64 11.53 139 119460 51604 79573185
Face oedema 19.63 11.53 89 119510 28047 79596742
Respiratory failure 19.62 11.53 175 119424 180736 79444053
Vision blurred 19.62 11.53 244 119355 105654 79519135
Paranoia 19.62 11.53 69 119530 19363 79605426
Neutropenic sepsis 19.60 11.53 8 119591 27056 79597733
Thirst 19.57 11.53 67 119532 18552 79606237
Ejection fraction decreased 19.53 11.53 14 119585 34563 79590226
Extradural abscess 19.51 11.53 17 119582 1495 79623294
Limb injury 19.41 11.53 10 119589 29518 79595271
Feeling cold 19.39 11.53 90 119509 28639 79596150
Anticoagulation drug level below therapeutic 19.31 11.53 17 119582 1516 79623273
Anaemia macrocytic 19.22 11.53 32 119567 5565 79619224
International normalised ratio increased 19.19 11.53 64 119535 84657 79540132
Pulmonary oedema 19.09 11.53 68 119531 88186 79536603
Peritoneal tuberculosis 18.95 11.53 11 119588 506 79624283
Urinary retention 18.92 11.53 35 119564 56595 79568194
Heart rate irregular 18.76 11.53 13 119586 32666 79592123
Ammonia abnormal 18.65 11.53 8 119591 190 79624599
Lymph node tuberculosis 18.60 11.53 14 119585 1000 79623789
Alpha 1 foetoprotein abnormal 18.55 11.53 6 119593 62 79624727
Chronic hepatic failure 18.54 11.53 14 119585 1005 79623784
Remission not achieved 18.53 11.53 10 119589 399 79624390
Hypoalbuminaemia 18.47 11.53 72 119527 21225 79603564
Haematocrit decreased 18.43 11.53 156 119443 61156 79563633
Genital herpes 18.42 11.53 19 119580 2065 79622724
Live birth 18.40 11.53 3 119596 18741 79606048
Toxic epidermal necrolysis 18.28 11.53 24 119575 44557 79580232
Back pain 18.13 11.53 334 119265 303846 79320943
Acute myeloid leukaemia 18.12 11.53 12 119587 30873 79593916
Blood bilirubin abnormal 17.97 11.53 16 119583 1449 79623340
Oral mucosal blistering 17.91 11.53 33 119566 6218 79618571
Liver function test increased 17.80 11.53 20 119579 39753 79585036
Neck pain 17.76 11.53 56 119543 75361 79549428
Fungal infection 17.61 11.53 22 119577 41726 79583063
Throat tightness 17.54 11.53 10 119589 27897 79596892
Injection site eczema 17.52 11.53 6 119593 75 79624714
Haemophilic arthropathy 17.47 11.53 7 119592 139 79624650
Hypocalcaemia 17.45 11.53 30 119569 49894 79574895
Coma hepatic 17.44 11.53 14 119585 1099 79623690
Breast cancer 17.41 11.53 15 119584 33766 79591023
Eczema asteatotic 17.34 11.53 11 119588 595 79624194
Status epilepticus 17.19 11.53 8 119591 25033 79599756
Torsade de pointes 17.05 11.53 4 119595 19308 79605481
Osteonecrosis 17.03 11.53 13 119586 31082 79593707
Bacterascites 17.02 11.53 4 119595 10 79624779
Granulocyte count decreased 16.92 11.53 17 119582 1791 79622998
Mitochondrial toxicity 16.77 11.53 22 119577 3092 79621697
Ventricular tachycardia 16.76 11.53 23 119576 41912 79582877
Hypoaesthesia 16.71 11.53 180 119419 179172 79445617
Hepatic lesion 16.59 11.53 34 119565 6925 79617864
Gene mutation identification test positive 16.53 11.53 8 119591 253 79624536
Model for end stage liver disease score 16.51 11.53 3 119596 0 79624789
Congenital uterine anomaly 16.51 11.53 3 119596 0 79624789
Benign oesophageal neoplasm 16.51 11.53 3 119596 0 79624789
Procalcitonin 16.49 11.53 4 119595 12 79624777
Immunodeficiency 16.49 11.53 6 119593 21762 79603027
Hypercalcaemia 16.47 11.53 20 119579 38410 79586379
Disseminated intravascular coagulation 16.46 11.53 101 119498 35741 79589048
Infective spondylitis 16.40 11.53 10 119589 504 79624285
Cheilitis 16.32 11.53 29 119570 5312 79619477
Pityriasis 16.25 11.53 4 119595 13 79624776
Disability 16.24 11.53 3 119596 17117 79607672
Overgrowth fungal 16.17 11.53 6 119593 96 79624693
Cardiac disorder 16.07 11.53 48 119551 65709 79559080
Hydrocholecystis 16.07 11.53 10 119589 523 79624266
Joint injury 16.05 11.53 14 119585 31321 79593468
Dystonia 16.04 11.53 6 119593 21393 79603396
Blister 16.03 11.53 109 119490 119367 79505422
Balance disorder 15.99 11.53 85 119514 98772 79526017
Extrapyramidal disorder 15.95 11.53 7 119592 22672 79602117
Hepatic mass 15.89 11.53 19 119580 2432 79622357
Myoclonus 15.89 11.53 11 119588 27649 79597140
Clostridium difficile colitis 15.85 11.53 15 119584 32268 79592521
Deafness 15.77 11.53 68 119531 20969 79603820
Hepatic amoebiasis 15.68 11.53 6 119593 105 79624684
Serum ferritin increased 15.64 11.53 41 119558 9806 79614983
Fluid retention 15.63 11.53 53 119546 69756 79555033
Cataract 15.43 11.53 45 119554 62075 79562714
Premature delivery 15.35 11.53 8 119591 23459 79601330
Subarachnoid haemorrhage 15.32 11.53 75 119524 24390 79600399
Blood pressure decreased 15.28 11.53 87 119512 99379 79525410
Granulomatous liver disease 15.25 11.53 14 119585 1319 79623470
Hair disorder 15.16 11.53 13 119586 1119 79623670
Grip strength decreased 14.99 11.53 7 119592 21862 79602927
Myelodysplastic syndrome 14.97 11.53 14 119585 30287 79594502
Therapy responder 14.93 11.53 9 119590 444 79624345
Lower gastrointestinal haemorrhage 14.93 11.53 3 119596 16122 79608667
Pancreas transplant rejection 14.87 11.53 8 119591 317 79624472
Hepatic function abnormal 14.66 11.53 171 119428 72936 79551853
Pathogen resistance 14.54 11.53 51 119548 14291 79610498
Metabolic acidosis 14.47 11.53 69 119530 82460 79542329
Aggression 14.45 11.53 128 119471 50830 79573959
Hashitoxicosis 14.44 11.53 3 119596 3 79624786
Exposure via partner 14.41 11.53 4 119595 23 79624766
VIIIth nerve lesion 14.41 11.53 4 119595 23 79624766
General physical condition abnormal 14.41 11.53 31 119568 6532 79618257
Decubitus ulcer 14.35 11.53 3 119596 15684 79609105
Rales 14.34 11.53 6 119593 19995 79604794
Papilloedema 14.33 11.53 30 119569 6203 79618586
Oesophageal variceal ligation 14.33 11.53 6 119593 134 79624655
Cholelithiasis 14.28 11.53 131 119468 52533 79572256
Tubulointerstitial nephritis 14.27 11.53 22 119577 38213 79586576
Chronic hepatitis 14.27 11.53 14 119585 1433 79623356
Sinus congestion 14.22 11.53 6 119593 19890 79604899
Lacrimation increased 14.21 11.53 8 119591 22469 79602320
Muscle rigidity 14.20 11.53 6 119593 19876 79604913
Incorrect product administration duration 14.19 11.53 45 119554 11977 79612812
Hypomagnesaemia 13.96 11.53 31 119568 46880 79577909
Heart rate increased 13.88 11.53 115 119484 120609 79504180
Haematochezia 13.82 11.53 76 119523 87569 79537220
Dyskinesia 13.81 11.53 29 119570 44744 79580045
Haemorrhoids thrombosed 13.78 11.53 7 119592 246 79624543
Bladder cancer 13.78 11.53 6 119593 19520 79605269
Hepatorenal failure 13.74 11.53 13 119586 1272 79623517
Liver function test abnormal 13.73 11.53 50 119549 64425 79560364
Femur fracture 13.71 11.53 23 119576 38629 79586160
Exposure via direct contact 13.65 11.53 5 119594 77 79624712
Bulimia nervosa 13.55 11.53 7 119592 255 79624534
Retinal disorder 13.49 11.53 16 119583 2031 79622758
Deafness neurosensory 13.37 11.53 31 119568 6867 79617922
Paraesthesia oral 13.36 11.53 7 119592 20464 79604325
Deafness unilateral 13.34 11.53 23 119576 4115 79620674
Ventricular fibrillation 13.28 11.53 17 119582 31909 79592880
CD4 lymphocytes decreased 13.25 11.53 18 119581 2616 79622173
Haemochromatosis 13.20 11.53 13 119586 1337 79623452
Angina pectoris 13.20 11.53 37 119562 51695 79573094
Wound infection 13.18 11.53 10 119589 23981 79600808
Portopulmonary hypertension 13.11 11.53 6 119593 167 79624622
Fat intolerance 13.06 11.53 4 119595 34 79624755
Prurigo 13.05 11.53 13 119586 1356 79623433
Injection site mass 13.02 11.53 7 119592 20177 79604612
Pulmonary sarcoidosis 12.98 11.53 13 119586 1364 79623425
Bipolar I disorder 12.98 11.53 16 119583 2113 79622676
Complication associated with device 12.95 11.53 5 119594 17491 79607298
Cerebral arteriovenous malformation haemorrhagic 12.91 11.53 3 119596 7 79624782
Tobacco user 12.87 11.53 10 119589 749 79624040
Smooth muscle antibody positive 12.75 11.53 6 119593 178 79624611
Hot flush 12.74 11.53 41 119558 54836 79569953
Suspected transmission of an infectious agent via product 12.69 11.53 12 119587 1174 79623615
Acquired porphyria 12.67 11.53 4 119595 38 79624751
Pulmonary hypertension 12.55 11.53 34 119565 48046 79576743
Hepatitis B 12.53 11.53 34 119565 8298 79616491
Xerosis 12.52 11.53 12 119587 1194 79623595
Injection site haemorrhage 12.49 11.53 14 119585 27856 79596933
Mononeuropathy multiplex 12.46 11.53 8 119591 442 79624347
Lichen planus 12.44 11.53 18 119581 2773 79622016
Pneumonitis 12.44 11.53 48 119551 60812 79563977
Psoriasis 12.38 11.53 81 119518 89506 79535283
Lower limb fracture 12.35 11.53 10 119589 23205 79601584
Intestinal obstruction 12.34 11.53 29 119570 42991 79581798
Ankle fracture 12.32 11.53 5 119594 16964 79607825
Rotator cuff syndrome 12.28 11.53 3 119596 14092 79610697
Hepatectomy 12.25 11.53 6 119593 195 79624594
Exostosis 12.18 11.53 5 119594 16853 79607936
Lung abscess 12.15 11.53 22 119577 4090 79620699
Faeces discoloured 12.09 11.53 80 119519 29047 79595742
Left ventricular dysfunction 12.08 11.53 7 119592 19354 79605435
Hyperalbuminaemia 12.06 11.53 4 119595 45 79624744
Granuloma annulare 12.05 11.53 9 119590 635 79624154
Spinal fracture 12.04 11.53 6 119593 18048 79606741
Facial paresis 12.02 11.53 26 119573 5500 79619289
Pemphigoid 11.98 11.53 4 119595 15311 79609478
Upper limb fracture 11.94 11.53 6 119593 17961 79606828
Factor VIII inhibition 11.88 11.53 7 119592 331 79624458
Antimitochondrial antibody positive 11.88 11.53 5 119594 113 79624676
Aspergillus infection 11.85 11.53 7 119592 19154 79605635
Hyperlipidaemia 11.81 11.53 13 119586 26080 79598709
Skin lesion 11.81 11.53 105 119494 41739 79583050
Bone disorder 11.80 11.53 7 119592 19106 79605683
Intentional self-injury 11.77 11.53 19 119580 32400 79592389
Hypokinesia 11.74 11.53 7 119592 19053 79605736
Accidental exposure to product 11.71 11.53 18 119581 31304 79593485
Influenza 11.70 11.53 131 119468 129475 79495314
Cortisol free urine decreased 11.70 11.53 3 119596 12 79624777
Oral tuberculosis 11.70 11.53 3 119596 12 79624777
Muscle twitching 11.59 11.53 12 119587 24752 79600037
Thyroiditis 11.58 11.53 23 119576 4582 79620207
Retinal vein thrombosis 11.56 11.53 9 119590 676 79624113

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Exposure via body fluid 61.94 36.84 10 47 3 89732

Pharmacologic Action:

SourceCodeDescription
ATC J05AP01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIVIRALS FOR SYSTEMIC USE
DIRECT ACTING ANTIVIRALS
Antivirals for treatment of HCV infections
FDA EXT N0000175459 Nucleoside Analog
FDA EPC N0000175466 Nucleoside Analog Antiviral
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000963 Antimetabolites
MeSH PA D000998 Antiviral Agents
MeSH PA D009676 Noxae
CHEBI has role CHEBI:22587 antiviral agents
CHEBI has role CHEBI:35221 antimetabolite
CHEBI has role CHEBI:35441 antiinfective agents
CHEBI has role CHEBI:59897 reverse transcriptase inhibitors
CHEBI has role CHEBI:149553 anticoronaviral drug

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Respiratory syncytial virus infection indication 55735004 DOID:1273
Chronic hepatitis C indication 128302006
Compensated cirrhosis indication 371139006
Lassa fever off-label use 19065005 DOID:9537
Influenza due to Influenza virus, type B off-label use 24662006
Congo-Crimean hemorrhagic fever off-label use 43489008 DOID:12287
Hemorrhagic nephroso-nephritis off-label use 102455002
Coronavirus infection off-label use 186747009
Rift valley fever off-label use 402917003 DOID:1328
Influenza due to Influenza A virus off-label use 442438000
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Cirrhosis of liver contraindication 19943007 DOID:5082
Myocardial infarction contraindication 22298006 DOID:5844
Constitutional aplastic anemia contraindication 28975000 DOID:1342
Sarcoidosis contraindication 31541009 DOID:11335
Thalassemia contraindication 40108008 DOID:10241
Periodontitis contraindication 41565005 DOID:824
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Hemolytic anemia contraindication 61261009 DOID:583
Interstitial pneumonia contraindication 64667001
Pancreatitis contraindication 75694006 DOID:4989
Pancytopenia contraindication 127034005 DOID:12450
Hb SS disease contraindication 127040003 DOID:10923
Asthma contraindication 195967001 DOID:2841
Impaired renal function disorder contraindication 197663003
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Bone marrow depression contraindication 307762000
Autoimmune hepatitis contraindication 408335007
Breastfeeding (mother) contraindication 413712001
Myocardial ischemia contraindication 414795007 DOID:3393
Pulmonary Infiltrates contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.65 acidic
pKa2 12.27 acidic
pKa3 13.44 acidic
pKa4 0.35 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Inosine-5'-monophosphate dehydrogenase 1 Enzyme INHIBITOR IC50 6 IUPHAR CHEMBL
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Enzyme WOMBAT-PK
Cytosolic purine 5'-nucleotidase Enzyme WOMBAT-PK
Inosine-5'-monophosphate dehydrogenase 2 Enzyme INHIBITOR IC50 6 IUPHAR
DNA topoisomerase 1 Enzyme IC50 4.18 CHEMBL
Adenosine receptor A1 GPCR Ki 5.13 CHEMBL
Adenosine kinase Kinase WOMBAT-PK
NS5B protein Enzyme INHIBITOR CHEMBL CHEMBL
NS5 Unclassified EC50 4.68 CHEMBL
Adenosine receptor A1 GPCR Ki 5.35 CHEMBL

External reference:

IDSource
4019299 VUID
N0000147496 NUI
D00423 KEGG_DRUG
4019299 VANDF
C0035525 UMLSCUI
CHEBI:63580 CHEBI
RBV PDB_CHEM_ID
CHEMBL1643 ChEMBL_ID
DB00811 DRUGBANK_ID
D012254 MESH_DESCRIPTOR_UI
37542 PUBCHEM_CID
6842 IUPHAR_LIGAND_ID
3543 INN_ID
49717AWG6K UNII
9344 RXNORM
43465 MMSL
5421 MMSL
d00085 MMSL
003018 NDDF
35063004 SNOMEDCT_US
387188005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
REBETOL HUMAN PRESCRIPTION DRUG LABEL 1 0085-1194 CAPSULE 200 mg ORAL NDA 31 sections
REBETOL HUMAN PRESCRIPTION DRUG LABEL 1 0085-1194 CAPSULE 200 mg ORAL NDA 31 sections
REBETOL HUMAN PRESCRIPTION DRUG LABEL 1 0085-1318 LIQUID 40 mg ORAL NDA 31 sections
REBETOL HUMAN PRESCRIPTION DRUG LABEL 1 0085-1318 LIQUID 40 mg ORAL NDA 31 sections
REBETOL HUMAN PRESCRIPTION DRUG LABEL 1 0085-1351 CAPSULE 200 mg ORAL NDA 31 sections
REBETOL HUMAN PRESCRIPTION DRUG LABEL 1 0085-1351 CAPSULE 200 mg ORAL NDA 31 sections
REBETOL HUMAN PRESCRIPTION DRUG LABEL 1 0085-1385 CAPSULE 200 mg ORAL NDA 31 sections
REBETOL HUMAN PRESCRIPTION DRUG LABEL 1 0085-1385 CAPSULE 200 mg ORAL NDA 31 sections
Virazole HUMAN PRESCRIPTION DRUG LABEL 1 0187-0007 POWDER, FOR SOLUTION 6 g RESPIRATORY (INHALATION) NDA 21 sections
Virazole HUMAN PRESCRIPTION DRUG LABEL 1 0187-0007 POWDER, FOR SOLUTION 6 g RESPIRATORY (INHALATION) NDA 21 sections
Ribavirin HUMAN PRESCRIPTION DRUG LABEL 1 42494-423 POWDER, FOR SOLUTION 6 g RESPIRATORY (INHALATION) NDA 23 sections
Ribavirin HUMAN PRESCRIPTION DRUG LABEL 1 53808-0781 CAPSULE 200 mg ORAL ANDA 21 sections
Ribavirin HUMAN PRESCRIPTION DRUG LABEL 1 53808-0782 TABLET, FILM COATED 200 mg ORAL ANDA 16 sections
Ribavirin HUMAN PRESCRIPTION DRUG LABEL 1 63629-2149 POWDER, FOR SOLUTION 6 g RESPIRATORY (INHALATION) NDA 22 sections
Ribavirin HUMAN PRESCRIPTION DRUG LABEL 1 63629-2149 POWDER, FOR SOLUTION 6 g RESPIRATORY (INHALATION) NDA 22 sections
Ribavirin HUMAN PRESCRIPTION DRUG LABEL 1 65841-046 TABLET, FILM COATED 200 mg ORAL ANDA 1 sections
Ribavirin HUMAN PRESCRIPTION DRUG LABEL 1 65841-046 TABLET, FILM COATED 200 mg ORAL ANDA 1 sections
Ribavirin HUMAN PRESCRIPTION DRUG LABEL 1 65841-129 TABLET, FILM COATED 600 mg ORAL ANDA 1 sections
Ribavirin HUMAN PRESCRIPTION DRUG LABEL 1 65841-129 TABLET, FILM COATED 600 mg ORAL ANDA 1 sections
Ribavirin HUMAN PRESCRIPTION DRUG LABEL 1 65841-260 CAPSULE 200 mg ORAL ANDA 1 sections
Ribavirin HUMAN PRESCRIPTION DRUG LABEL 1 65841-260 CAPSULE 200 mg ORAL ANDA 1 sections
Ribavirin HUMAN PRESCRIPTION DRUG LABEL 1 65841-603 TABLET, FILM COATED 400 mg ORAL ANDA 1 sections
Ribavirin HUMAN PRESCRIPTION DRUG LABEL 1 65841-603 TABLET, FILM COATED 400 mg ORAL ANDA 1 sections
Ribavirin HUMAN PRESCRIPTION DRUG LABEL 1 65841-632 TABLET, FILM COATED 500 mg ORAL ANDA 1 sections
Ribavirin HUMAN PRESCRIPTION DRUG LABEL 1 65841-632 TABLET, FILM COATED 500 mg ORAL ANDA 1 sections
Ribavirin Human Prescription Drug Label 1 65862-207 TABLET, FILM COATED 200 mg ORAL ANDA 28 sections
Ribavirin Human Prescription Drug Label 1 65862-207 TABLET, FILM COATED 200 mg ORAL ANDA 28 sections
Ribavirin Human Prescription Drug Label 1 65862-207 TABLET, FILM COATED 200 mg ORAL ANDA 28 sections
Ribavirin Human Prescription Drug Label 1 65862-290 CAPSULE 200 mg ORAL ANDA 28 sections
Ribavirin Human Prescription Drug Label 1 65862-290 CAPSULE 200 mg ORAL ANDA 28 sections