DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
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L1000
FAQ
Scroll
All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
ramosetron 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
serotonin receptor antagonists (5-HT3)
2357
132036-88-5
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
YM-060
ramosetron
ibsetron hydrochloride
ibsetron
ramosetron hydrochloride
irribow
ibsetron HCl
ramosetron HCl
Molecular weight: 279.34
Formula: C17H17N3O
CLOGP: 2.13
LIPINSKI: 0
HAC: 4
HDO: 1
TPSA: 50.68
ALOGS: -3.61
ROTB: 2
Drug dosage:
None
ADMET properties:
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Property
Value
Reference
CL (Clearance)
7.03 mL/min/kg
Lombardo F, Berellini G, Obach RS
t_half (Half-life)
4.94 hours
Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)
2.65 L/kg
Lombardo F, Berellini G, Obach RS
BA (Bioavailability)
0.56 %
Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K
Showing 1 to 4 of 4 entries
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Approvals:
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Date
Agency
Company
Orphan
July 10, 1996
PMDA
Astellas
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Platelet count decreased
60.61
39.79
36
1065
194628
79548659
White blood cell count decreased
53.88
39.79
33
1068
188255
79555032
Neutrophil count decreased
47.56
39.79
24
1077
93935
79649352
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
MeSH PA
D000932
Antiemetics
MeSH PA
D002491
Central Nervous System Agents
MeSH PA
D005765
Gastrointestinal Agents
MeSH PA
D018377
Neurotransmitter Agents
MeSH PA
D018373
Peripheral Nervous System Agents
MeSH PA
D018490
Serotonin Agents
MeSH PA
D012702
Serotonin Antagonists
Showing 1 to 7 of 7 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Irritable bowel syndrome with diarrhea
indication
197125005
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
11.88
acidic
pKa2
5.69
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
5-hydroxytryptamine receptor 3A
Ion channel
P46098
5HT3A_HUMAN
ANTAGONIST
Ki
10.22
CHEMBL
SCIENTIFIC LITERATURE
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External reference:
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entries
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ID
Source
010967
NDDF
010968
NDDF
108000
PUBCHEM_CID
132907-72-3
SECONDARY_CAS_RN
2301
IUPHAR_LIGAND_ID
7161
INN_ID
7ZRO0SC54Y
UNII
C0526950
UMLSCUI
C071315
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:32088
CHEBI
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Pharmaceutical products:
None
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ramosetron