ramosetron 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
serotonin receptor antagonists (5-HT3) 2357 132036-88-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • YM-060
  • ramosetron
  • ibsetron hydrochloride
  • ibsetron
  • ramosetron hydrochloride
  • irribow
  • ibsetron HCl
  • ramosetron HCl
  • Molecular weight: 279.34
  • Formula: C17H17N3O
  • CLOGP: 2.13
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 50.68
  • ALOGS: -3.61
  • ROTB: 2

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 2.65 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7.03 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 4.94 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 10, 1996 PMDA Astellas

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Platelet count decreased 53.03 39.30 32 914 167679 64330107
White blood cell count decreased 49.58 39.30 30 916 157807 64339979
Neutrophil count decreased 44.64 39.30 22 924 77174 64420612

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000932 Antiemetics
MeSH PA D002491 Central Nervous System Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018490 Serotonin Agents
MeSH PA D012702 Serotonin Antagonists

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Irritable bowel syndrome with diarrhea indication 197125005




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.88 acidic
pKa2 5.69 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
5-hydroxytryptamine receptor 3A Ion channel ANTAGONIST Ki 10.22 CHEMBL SCIENTIFIC LITERATURE

External reference:

IDSource
D02016 KEGG_DRUG
132907-72-3 SECONDARY_CAS_RN
C0526950 UMLSCUI
CHEBI:32088 CHEBI
CHEMBL1643895 ChEMBL_ID
CHEMBL3181841 ChEMBL_ID
DB09290 DRUGBANK_ID
C071315 MESH_SUPPLEMENTAL_RECORD_UI
108000 PUBCHEM_CID
2301 IUPHAR_LIGAND_ID
7161 INN_ID
7ZRO0SC54Y UNII
010967 NDDF
010968 NDDF

Pharmaceutical products:

None