ramipril 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
angiotensin-converting enzyme inhibitors 2356 87333-19-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • HOE498
  • HOE-498
  • ramipril
A long-acting angiotensin-converting enzyme inhibitor. It is a prodrug that is transformed in the liver to its active metabolite ramiprilat.
  • Molecular weight: 416.52
  • Formula: C23H32N2O5
  • CLOGP: 1.54
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 95.94
  • ALOGS: -4.03
  • ROTB: 10
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2.50 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.69 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 28 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
S (Water solubility) 0.09 mg/mL Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
Jan. 28, 1991 FDA KING PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 833.09 10.20 2284 201959 261131 63023648
Hyperkalaemia 637.30 10.20 828 203415 53375 63231404
Hyponatraemia 630.88 10.20 1220 203023 110680 63174099
General physical health deterioration 576.03 10.20 1685 202558 199717 63085062
Liver injury 520.49 10.20 796 203447 59724 63225055
Product dose omission issue 357.68 10.20 153 204090 234160 63050619
Angioedema 338.76 10.20 577 203666 47388 63237391
Drug interaction 337.08 10.20 1545 202698 227586 63057193
Completed suicide 333.12 10.20 39 204204 145634 63139145
Drug ineffective 328.47 10.20 1998 202245 1042767 62242012
Product prescribing error 314.17 10.20 405 203838 25884 63258895
Psoriatic arthropathy 283.79 10.20 789 203454 90731 63194048
Bradycardia 261.15 10.20 665 203578 72562 63212217
Syncope 247.85 10.20 886 203357 116499 63168280
Hypertensive crisis 245.96 10.20 274 203969 15012 63269767
Lactic acidosis 242.36 10.20 439 203804 37848 63246931
Hypotension 225.40 10.20 1575 202668 271029 63013750
Death 218.10 10.20 558 203685 373823 62910956
Confusional state 177.02 10.20 1334 202909 235046 63049733
Product monitoring error 173.85 10.20 132 204111 4384 63280395
Cardiac failure 156.86 10.20 635 203608 88507 63196272
Swollen tongue 156.50 10.20 346 203897 34454 63250325
Sopor 154.29 10.20 265 203978 21899 63262880
Hypoglycaemia 150.19 10.20 480 203763 59585 63225194
Eosinophilic bronchitis 147.34 10.20 59 204184 514 63284265
Injection site pain 136.07 10.20 130 204113 129670 63155109
White blood cell count decreased 130.50 10.20 153 204090 138951 63145828
Dehydration 126.12 10.20 972 203271 172382 63112397
Labelled drug-drug interaction medication error 123.30 10.20 182 204061 13217 63271562
Injection site erythema 121.00 10.20 58 204185 83116 63201663
Angina pectoris 118.64 10.20 284 203959 29794 63254985
Melaena 116.87 10.20 284 203959 30081 63254698
Atrial fibrillation 112.61 10.20 701 203542 115935 63168844
Lip swelling 108.50 10.20 280 203963 30783 63253996
Rhabdomyolysis 106.93 10.20 348 203895 43603 63241176
Hospitalisation 104.33 10.20 73 204170 85008 63199771
Rheumatoid arthritis 104.04 10.20 1261 202982 252558 63032221
Dizziness 101.67 10.20 1944 202299 427981 62856798
Off label use 99.00 10.20 1551 202692 672911 62611868
Tongue oedema 96.70 10.20 95 204148 4491 63280288
Prescribed overdose 96.61 10.20 285 203958 33868 63250911
Sinusitis 95.39 10.20 390 203853 226263 63058516
Device expulsion 95.03 10.20 4 204239 34918 63249861
Pain 92.34 10.20 1754 202489 738874 62545905
Medication error 89.21 10.20 369 203874 51915 63232864
Myocardial infarction 87.58 10.20 586 203657 99307 63185472
Ejection fraction decreased 87.14 10.20 210 204033 22122 63262657
Presyncope 86.49 10.20 240 204003 27545 63257234
Ischaemic stroke 85.82 10.20 183 204060 17774 63267005
Abortion spontaneous 81.77 10.20 25 204218 47170 63237609
Therapy interrupted 81.29 10.20 6 204237 32449 63252330
Polyp 78.73 10.20 101 204142 6420 63278359
Electrolyte imbalance 78.57 10.20 189 204054 19887 63264892
Wrong technique in product usage process 78.41 10.20 52 204191 62288 63222491
Injection site pruritus 77.98 10.20 24 204219 45092 63239687
Fall 76.59 10.20 1725 202518 390609 62894170
Jaundice 73.31 10.20 234 204009 29017 63255762
Febrile neutropenia 73.14 10.20 171 204072 118278 63166501
Disease progression 71.26 10.20 183 204060 122575 63162204
Blood pressure increased 71.13 10.20 816 203427 161246 63123533
Asphyxia 70.37 10.20 93 204150 6088 63278691
Orthostatic intolerance 69.48 10.20 45 204198 1152 63283627
Injection site swelling 69.45 10.20 33 204210 47539 63237240
Orthostatic hypotension 67.11 10.20 262 203981 35898 63248881
International normalised ratio increased 66.53 10.20 311 203932 46114 63238665
Haematemesis 65.34 10.20 231 204012 30181 63254598
Circulatory collapse 64.86 10.20 186 204057 21752 63263027
Therapeutic product effect incomplete 64.75 10.20 197 204046 124859 63159920
Systemic infection 64.00 10.20 77 204166 4583 63280196
Haematoma 63.57 10.20 251 203992 34569 63250210
Acute myocardial infarction 63.10 10.20 237 204006 31887 63252892
Facet joint syndrome 61.85 10.20 127 204116 12011 63272768
Sciatica 61.52 10.20 246 203997 34078 63250701
Platelet count decreased 61.50 10.20 181 204062 115941 63168838
No adverse event 60.01 10.20 29 204214 41376 63243403
Neuropathy peripheral 59.60 10.20 178 204065 113489 63171290
Drug hypersensitivity 59.39 10.20 676 203567 310011 62974768
Renin increased 57 10.20 22 204221 172 63284607
Bronchitis 57.00 10.20 208 204035 124727 63160052
Pyrexia 56.96 10.20 1119 203124 469359 62815420
Upper respiratory tract infection 56.85 10.20 111 204132 81936 63202843
Deep vein thrombosis postoperative 56.81 10.20 118 204125 11251 63273528
Glomerular filtration rate decreased 56.36 10.20 130 204113 13311 63271468
Drug ineffective for unapproved indication 55.58 10.20 20 204223 34043 63250736
Haematochezia 55.56 10.20 328 203915 53216 63231563
Unevaluable event 54.37 10.20 51 204192 51335 63233444
Arrhythmia 54.29 10.20 255 203988 37885 63246894
Swollen joint count increased 53.49 10.20 244 203999 35810 63248969
Feeling abnormal 53.04 10.20 271 203972 148121 63136658
Change of bowel habit 53.03 10.20 49 204194 2144 63282635
Infection 51.86 10.20 479 203764 228694 63056085
Rash 51.33 10.20 1393 202850 559478 62725301
Pneumonia 51.24 10.20 1100 203143 455667 62829112
Multiple sclerosis relapse 50.25 10.20 49 204194 48429 63236350
Neutrophilia 49.71 10.20 66 204177 4340 63280439
Surgery 49.30 10.20 27 204216 35885 63248894
Lip dry 48.51 10.20 134 204109 15336 63269443
Nephritic syndrome 48.41 10.20 23 204220 313 63284466
Headache 48.03 10.20 1613 202630 631628 62653151
Hypersensitivity myocarditis 47.89 10.20 20 204223 196 63284583
Urosepsis 47.16 10.20 149 204094 18375 63266404
Disorientation 47.12 10.20 251 203992 39201 63245578
Injection site reaction 47.10 10.20 72 204171 58452 63226327
Pallor 46.94 10.20 209 204034 30359 63254420
Toxicity to various agents 46.82 10.20 539 203704 246711 63038068
Fungal infection 46.04 10.20 31 204212 36843 63247936
Peripheral venous disease 45.54 10.20 131 204112 15346 63269433
Anuria 43.68 10.20 113 204130 12438 63272341
Autoimmune disorder 43.58 10.20 138 204105 17039 63267740
Renal impairment 43.38 10.20 455 203788 87900 63196879
Accidental exposure to product 43.19 10.20 17 204226 27388 63257391
Arteriosclerosis coronary artery 43.13 10.20 88 204155 8285 63276494
Diabetic metabolic decompensation 42.89 10.20 39 204204 1671 63283108
Rheumatic fever 42.75 10.20 261 203982 42850 63241929
Gangrene 42.33 10.20 73 204170 6050 63278729
Renal failure 41.97 10.20 570 203673 117082 63167697
COVID-19 41.87 10.20 204 204039 112899 63171880
Influenza 41.48 10.20 194 204049 108528 63176251
Cerebral ischaemia 41.11 10.20 76 204167 6652 63278127
Injection site rash 40.65 10.20 6 204237 18803 63265976
Blood creatinine increased 40.63 10.20 447 203796 87397 63197382
Device issue 40.47 10.20 13 204230 23768 63261011
Back pain 40.40 10.20 602 203641 263543 63021236
Arterial occlusive disease 39.85 10.20 70 204173 5888 63278891
Bradyarrhythmia 39.45 10.20 41 204202 2074 63282705
Intestinal haemorrhage 39.42 10.20 55 204188 3792 63280987
Abdominal pain upper 39.33 10.20 905 203338 205539 63079240
Bradyphrenia 39.12 10.20 76 204167 6904 63277875
Respiratory arrest 38.71 10.20 29 204214 32616 63252163
Prescribed underdose 38.30 10.20 193 204050 29496 63255283
Hemiparesis 37.90 10.20 162 204081 23120 63261659
Arthralgia 37.76 10.20 1475 202768 568235 62716544
Left ventricular dysfunction 37.75 10.20 104 204139 11884 63272895
Labile hypertension 37.74 10.20 22 204221 464 63284315
Blood creatine increased 37.71 10.20 66 204177 5535 63279244
Electrocardiogram abnormal 37.63 10.20 88 204155 9091 63275688
Troponin I increased 37.52 10.20 41 204202 2197 63282582
Therapy cessation 37.50 10.20 26 204217 30431 63254348
Mitral valve incompetence 37.19 10.20 143 204100 19451 63265328
Duodenal ulcer 37.01 10.20 79 204164 7677 63277102
Neutropenia 36.52 10.20 373 203870 174632 63110147
Seizure 36.49 10.20 263 203980 132371 63152408
Delirium 36.47 10.20 283 203960 50258 63234521
Inappropriate antidiuretic hormone secretion 36.32 10.20 121 204122 15341 63269438
Neutrophil count decreased 35.96 10.20 80 204163 56326 63228453
Atrioventricular block first degree 35.77 10.20 75 204168 7198 63277581
Chest pain 35.53 10.20 928 203315 215031 63069748
Joint injury 35.42 10.20 26 204217 29546 63255233
Pancreatitis acute 35.33 10.20 177 204066 26989 63257790
Blood creatine phosphokinase increased 35.25 10.20 192 204051 30238 63254541
Drug withdrawal syndrome 35.12 10.20 22 204221 27172 63257607
Cerebral haemorrhage 35.00 10.20 193 204050 30536 63254243
Limb reduction defect 34.98 10.20 20 204223 406 63284373
Dysmorphism 34.96 10.20 40 204203 2256 63282523
Fibromyalgia 34.83 10.20 404 203839 80016 63204763
Pancreatic neuroendocrine tumour 34.77 10.20 20 204223 411 63284368
Type 2 diabetes mellitus 34.77 10.20 336 203907 63532 63221247
Mental status changes 34.55 10.20 46 204197 39553 63245226
Lip oedema 34.24 10.20 52 204191 3872 63280907
Pemphigoid 34.12 10.20 74 204169 7270 63277509
Vomiting 34.08 10.20 2160 202083 557457 62727322
Patent ductus arteriosus 33.85 10.20 54 204189 4196 63280583
Device malfunction 33.68 10.20 8 204235 17849 63266930
Sedation complication 33.38 10.20 3 204240 13819 63270960
Plasma cell myeloma 33.10 10.20 40 204203 35865 63248914
Seasonal allergy 33.01 10.20 13 204230 20937 63263842
Bicuspid aortic valve 33 10.20 13 204230 108 63284671
Rectal haemorrhage 32.90 10.20 270 203973 48760 63236019
Macular degeneration 32.49 10.20 19 204224 24357 63260422
Abnormal loss of weight 32.46 10.20 63 204180 5719 63279060
Colitis microscopic 32.42 10.20 84 204159 9255 63275524
Therapeutic response unexpected 32.38 10.20 10 204233 18749 63266030
Gingival hypertrophy 32.26 10.20 33 204210 1638 63283141
Pulmonary fibrosis 32.18 10.20 229 204014 39580 63245199
Tachyarrhythmia 32.01 10.20 54 204189 4396 63280383
Hypercreatininaemia 32.00 10.20 21 204222 550 63284229
Herpes zoster 31.53 10.20 147 204096 82315 63202464
Asthenia 31.46 10.20 1522 202721 382082 62902697
Chills 31.09 10.20 225 204018 113153 63171626
Sedation 30.98 10.20 48 204195 38761 63246018
Malignant neoplasm progression 30.46 10.20 148 204095 81973 63202806
Flushing 30.43 10.20 131 204112 74956 63209823
Therapeutic drug monitoring analysis not performed 30.37 10.20 29 204214 1323 63283456
Weight increased 30.36 10.20 624 203619 260168 63024611
Coronary artery disease 30.22 10.20 193 204050 32184 63252595
Oedema peripheral 30.19 10.20 811 203432 188700 63096079
Inappropriate schedule of product administration 30.14 10.20 203 204040 103762 63181017
Diabetes mellitus inadequate control 30.04 10.20 112 204131 15014 63269765
Neck pain 29.92 10.20 118 204125 69200 63215579
Nasal congestion 29.48 10.20 110 204133 65550 63219229
Device dislocation 29.01 10.20 24 204219 25681 63259098
Gastroenteritis clostridial 28.94 10.20 20 204223 572 63284207
Bacteraemia 28.62 10.20 10 204233 17338 63267441
Dysarthria 28.55 10.20 235 204008 42476 63242303
Sleep disorder due to a general medical condition 28.50 10.20 3 204240 12185 63272594
Congestive cardiomyopathy 28.39 10.20 62 204181 6120 63278659
Bundle branch block left 28.20 10.20 67 204176 6992 63277787
Laboratory test abnormal 28.12 10.20 27 204216 26885 63257894
Chronic sinusitis 27.98 10.20 4 204239 12839 63271940
Hyperglycaemia 27.79 10.20 230 204013 41637 63243142
Adjustment disorder with depressed mood 27.76 10.20 84 204159 10120 63274659
Restlessness 27.75 10.20 176 204067 29277 63255502
Anaemia 27.46 10.20 1180 203063 292250 62992529
Oral candidiasis 27.36 10.20 20 204223 22778 63262001
Electrocardiogram QT prolonged 27.10 10.20 302 203941 59228 63225551
Gastrointestinal disorder 26.85 10.20 281 203962 130958 63153821
Rectal polyp 26.75 10.20 26 204217 1213 63283566
Glossodynia 26.66 10.20 759 203484 178117 63106662
Hypoglycaemic coma 26.66 10.20 37 204206 2538 63282241
Gamma-glutamyltransferase increased 26.49 10.20 194 204049 33837 63250942
Tenosynovitis 26.38 10.20 6 204237 13789 63270990
Pancreatitis necrotising 26.36 10.20 30 204213 1682 63283097
Illness 26.30 10.20 76 204167 48983 63235796
Ill-defined disorder 26.08 10.20 155 204088 81600 63203179
Hepatic function abnormal 25.94 10.20 50 204193 37092 63247687
Hypertensive emergency 25.69 10.20 31 204212 1851 63282928
Cytomegalovirus infection 25.64 10.20 18 204225 20934 63263845
Full blood count abnormal 25.54 10.20 39 204204 31678 63253101
Fatigue 25.52 10.20 2486 201757 885542 62399237
Talipes 25.45 10.20 28 204215 1512 63283267
Blood cholesterol increased 25.20 10.20 434 203809 93598 63191181
Productive cough 25.17 10.20 111 204132 63097 63221682
Lupus vulgaris 25.16 10.20 58 204185 5936 63278843
Bundle branch block right 25.12 10.20 52 204191 4946 63279833
Constipation 25.07 10.20 542 203701 224401 63060378
Cerebrovascular accident 24.91 10.20 487 203756 107537 63177242
Parkinsonism 24.79 10.20 82 204161 10357 63274422
Neoplasm malignant 24.74 10.20 36 204207 29825 63254954
Injection site bruising 24.67 10.20 62 204181 41848 63242931
Device stimulation issue 24.67 10.20 9 204234 59 63284720
Migraine 24.66 10.20 213 204030 103133 63181646
Skin weeping 24.64 10.20 20 204223 733 63284046
Cardiac failure chronic 24.64 10.20 48 204195 4370 63280409
Stomatitis 24.48 10.20 307 203936 138418 63146361
Atrioventricular block complete 24.43 10.20 70 204173 8181 63276598
Pain in jaw 24.34 10.20 66 204177 43430 63241349
Transplant rejection 24.34 10.20 3 204240 10777 63274002
Excessive eye blinking 24.21 10.20 25 204218 1255 63283524
Hypersensitivity 24.14 10.20 737 203506 291948 62992831
Cardio-respiratory arrest 24.05 10.20 105 204138 59854 63224925
Pharyngitis streptococcal 24.02 10.20 3 204240 10669 63274110
Respiratory tract inflammation 24.01 10.20 18 204225 586 63284193
Eosinophilia 23.99 10.20 140 204103 22616 63262163
Mobility decreased 23.95 10.20 534 203709 120625 63164154
Breast cancer female 23.82 10.20 7 204236 13552 63271227
Angina unstable 23.79 10.20 63 204180 7032 63277747
Renal artery stenosis 23.73 10.20 30 204213 1879 63282900
Psoriasis 23.63 10.20 173 204070 86784 63197995
Cholestasis 23.61 10.20 169 204074 29265 63255514
Heavy menstrual bleeding 23.48 10.20 14 204229 17759 63267020
Suicidal ideation 23.44 10.20 112 204131 62309 63222470
Mucosal dryness 23.43 10.20 36 204207 2708 63282071
Injection site urticaria 23.41 10.20 8 204235 14065 63270714
Erysipelas 23.34 10.20 67 204176 7838 63276941
Limb hypoplasia congenital 23.26 10.20 12 204231 197 63284582
Eye irritation 23.01 10.20 22 204221 21949 63262830
Fracture 22.97 10.20 124 204119 19460 63265319
Oedema 22.81 10.20 441 203802 97181 63187598
Acute coronary syndrome 22.69 10.20 78 204165 10048 63274731
Hypokalaemia 22.60 10.20 464 203779 103340 63181439
Vertigo 22.53 10.20 293 203950 59594 63225185
Injection site haemorrhage 22.51 10.20 27 204216 24287 63260492
Stoma site haemorrhage 22.23 10.20 22 204221 1049 63283730
Oral dysaesthesia 22.12 10.20 9 204234 82 63284697
Stupor 22.10 10.20 45 204198 4230 63280549
Dermatitis exfoliative 22.01 10.20 52 204191 5407 63279372
Dry eye 21.96 10.20 63 204180 40698 63244081
Hypertensive angiopathy 21.94 10.20 9 204234 84 63284695
Hepatorenal failure 21.80 10.20 18 204225 676 63284103
Eosinophil count increased 21.77 10.20 81 204162 10847 63273932
Neurotoxicity 21.59 10.20 14 204229 16976 63267803
Multiple sclerosis 21.58 10.20 28 204215 24344 63260435
Reduced facial expression 21.49 10.20 29 204214 1937 63282842
Laryngeal oedema 21.48 10.20 53 204190 5665 63279114
Tachycardia 21.26 10.20 514 203729 117642 63167137
Basilar artery thrombosis 21.18 10.20 10 204233 134 63284645
Oral herpes 21.05 10.20 32 204211 26042 63258737
Palpitations 21.03 10.20 493 203750 112277 63172502
Irritability 20.99 10.20 44 204199 31650 63253129
Hypoxia 20.90 10.20 110 204133 59682 63225097
Respiratory depression 20.82 10.20 9 204234 13706 63271073
Congenital choroid plexus cyst 20.81 10.20 13 204230 312 63284467
Fluid retention 20.75 10.20 110 204133 59576 63225203
Heat stroke 20.61 10.20 19 204224 829 63283950
Congenital oral malformation 20.52 10.20 11 204232 196 63284583
Hypovolaemic shock 20.51 10.20 55 204188 6186 63278593
Pulmonary toxicity 20.47 10.20 3 204240 9452 63275327
Congenital aortic valve stenosis 20.46 10.20 8 204235 65 63284714
Acne 20.38 10.20 27 204216 23266 63261513
Chest wall haematoma 20.37 10.20 11 204232 199 63284580
Colitis erosive 20.32 10.20 9 204234 103 63284676
Obstructive airways disorder 20.32 10.20 125 204118 20574 63264205
Peripheral circulatory failure 20.31 10.20 20 204223 948 63283831
Peripheral arterial occlusive disease 20.29 10.20 43 204200 4158 63280621
Clostridium difficile infection 20.27 10.20 41 204202 29881 63254898
Electrocardiogram repolarisation abnormality 20.15 10.20 23 204220 1294 63283485
Cardiovascular insufficiency 20.10 10.20 24 204219 1417 63283362
Infusion site pain 19.98 10.20 15 204228 16854 63267925
Pulmonary mass 19.97 10.20 26 204217 22570 63262209
Apathy 19.93 10.20 68 204175 8726 63276053
Cerebral artery occlusion 19.73 10.20 19 204224 876 63283903
Diabetes mellitus 19.73 10.20 270 203973 55540 63229239
Left ventricular hypertrophy 19.69 10.20 49 204194 5266 63279513
Respiratory failure 19.66 10.20 221 204022 101637 63183142
Red blood cell count decreased 19.64 10.20 66 204177 40579 63244200
Dystonia 19.54 10.20 10 204233 13809 63270970
Abdominal pain 19.54 10.20 1142 203101 292314 62992465
Abnormal clotting factor 19.52 10.20 9 204234 114 63284665
Arthropathy 19.51 10.20 933 203310 233859 63050920
Product storage error 19.45 10.20 12 204231 14944 63269835
Congenital renal cyst 19.36 10.20 5 204238 7 63284772
Bronchomalacia 19.34 10.20 11 204232 221 63284558
Acute pulmonary oedema 19.30 10.20 64 204179 8094 63276685
Psychogenic tremor 19.28 10.20 6 204237 22 63284757
Musculoskeletal pain 19.28 10.20 410 203833 91867 63192912
Vaginal haemorrhage 19.20 10.20 37 204206 27450 63257329
Intentional product misuse 19.16 10.20 116 204127 60801 63223978
Blood pressure systolic increased 19.15 10.20 235 204008 47162 63237617
Retrognathia 19.11 10.20 14 204229 440 63284339
Liver function test abnormal 19.08 10.20 238 204005 47943 63236836
Cellulitis 19.07 10.20 170 204073 81788 63202991
Infusion site extravasation 19.03 10.20 5 204238 10421 63274358
Atrioventricular block 19.00 10.20 61 204182 7586 63277193
Macrophage activation 18.97 10.20 4 204239 0 63284779
Rhinitis allergic 18.94 10.20 7 204236 11720 63273059
Hepatotoxicity 18.70 10.20 59 204184 36982 63247797
Adrenal insufficiency 18.69 10.20 18 204225 17897 63266882
Foetal death 18.69 10.20 6 204237 10974 63273805
Paresis 18.60 10.20 31 204212 2499 63282280
Rhinorrhoea 18.53 10.20 129 204114 65448 63219331
Blood immunoglobulin A decreased 18.48 10.20 22 204221 1295 63283484
Device breakage 18.45 10.20 7 204236 11535 63273244
Hysterectomy 18.43 10.20 4 204239 9495 63275284
Listless 18.35 10.20 33 204210 2827 63281952
Agitation 18.31 10.20 282 203961 59475 63225304
Myelosuppression 18.27 10.20 30 204213 23673 63261106
Hypersomnia 17.86 10.20 19 204224 18036 63266743
Thrombocytosis 17.85 10.20 50 204193 5768 63279011
Visceral congestion 17.84 10.20 12 204231 328 63284451
Atrial septal defect 17.84 10.20 56 204187 6882 63277897
Tooth dislocation 17.80 10.20 6 204237 30 63284749
Arterial stenosis 17.71 10.20 15 204228 584 63284195
Drug resistance 17.70 10.20 29 204214 22904 63261875
Wound 17.67 10.20 667 203576 162596 63122183
Pemphigus 17.65 10.20 741 203502 182985 63101794
Faecaloma 17.64 10.20 61 204182 7880 63276899
Cardioactive drug level increased 17.59 10.20 28 204215 2172 63282607
Irregular sleep wake rhythm disorder 17.58 10.20 10 204233 201 63284578
Coma scale abnormal 17.53 10.20 46 204197 5107 63279672
Blood lactic acid 17.51 10.20 8 204235 99 63284680
Product quality issue 17.50 10.20 58 204185 35807 63248972
Blood calcium decreased 17.28 10.20 37 204206 26414 63258365
Muscle contractions involuntary 17.17 10.20 29 204214 2363 63282416
Injury 17.14 10.20 331 203912 72916 63211863
Decreased appetite 17.09 10.20 979 203264 250073 63034706
Spinal operation 17.06 10.20 3 204240 8268 63276511
Pulmonary arterial hypertension 17.01 10.20 29 204214 22548 63262231
Musculoskeletal disorder 16.99 10.20 25 204218 20619 63264160
Tubulointerstitial nephritis 16.97 10.20 116 204127 19787 63264992
Pharyngitis 16.97 10.20 24 204219 20119 63264660
Transient ischaemic attack 16.94 10.20 191 204052 37562 63247217
Incorrect dose administered 16.92 10.20 118 204125 59850 63224929
Procedural pain 16.91 10.20 27 204216 21542 63263237
Jaundice hepatocellular 16.90 10.20 6 204237 36 63284743
Mesenteric arterial occlusion 16.85 10.20 9 204234 159 63284620
Frontotemporal dementia 16.83 10.20 12 204231 361 63284418
Nodule 16.79 10.20 26 204217 21000 63263779
Blood glucose fluctuation 16.76 10.20 42 204201 4534 63280245
Brain stem stroke 16.72 10.20 12 204231 365 63284414
Dilatation ventricular 16.71 10.20 29 204214 2416 63282363
Complication associated with device 16.64 10.20 18 204225 16960 63267819
Hypothermia 16.62 10.20 87 204156 13494 63271285
Hyponatraemic syndrome 16.62 10.20 14 204229 541 63284238
Thrombosis 16.57 10.20 131 204112 64624 63220155
Intestinal obstruction 16.47 10.20 48 204195 30851 63253928
Pain in extremity 16.47 10.20 885 203358 330601 62954178
Loss of consciousness 16.44 10.20 497 203746 117624 63167155
Mitral valve disease 16.41 10.20 29 204214 2451 63282328
Dislocation of vertebra 16.37 10.20 63 204180 8572 63276207
Carotid artery thrombosis 16.37 10.20 31 204212 2763 63282016
Mitral valve atresia 16.36 10.20 5 204238 17 63284762
Urinary retention 16.28 10.20 159 204084 30142 63254637
Failure to suspend medication 16.24 10.20 6 204237 41 63284738
Multiple drug therapy 16.10 10.20 36 204207 3610 63281169
X-ray abnormal 16.06 10.20 60 204183 8050 63276729
Hepatitis acute 16.05 10.20 65 204178 9055 63275724
Hypomagnesaemia 16.04 10.20 152 204091 28585 63256194
Blood potassium decreased 16.01 10.20 75 204168 41951 63242828
Pneumonia herpes viral 15.99 10.20 6 204237 43 63284736
Fracture blisters 15.89 10.20 7 204236 79 63284700
Candida infection 15.88 10.20 43 204200 28308 63256471
Encephalopathy 15.87 10.20 67 204176 38553 63246226
Electrocardiogram QT shortened 15.86 10.20 8 204235 125 63284654
Skin infection 15.74 10.20 15 204228 14987 63269792
Throat irritation 15.67 10.20 65 204178 37582 63247197
Urine abnormality 15.67 10.20 54 204189 6965 63277814
Brain stem infarction 15.66 10.20 16 204227 793 63283986
Contraindicated product administered 15.64 10.20 853 203390 216795 63067984
Gingival swelling 15.60 10.20 40 204203 4378 63280401
Burns second degree 15.57 10.20 25 204218 1953 63282826
Viral diarrhoea 15.51 10.20 9 204234 188 63284591
Kidney infection 15.50 10.20 32 204211 23144 63261635
Rheumatic disorder 15.48 10.20 32 204211 3040 63281739
Infusion related reaction 15.48 10.20 639 203604 244882 63039897
Nephrosclerosis 15.44 10.20 18 204225 1036 63283743
Urine output decreased 15.44 10.20 75 204168 11295 63273484
Hallucination 15.41 10.20 255 203988 54562 63230217
Cholecystitis chronic 15.41 10.20 7 204236 10354 63274425
Cytokine release syndrome 15.38 10.20 14 204229 14300 63270479
Dermatitis atopic 15.38 10.20 6 204237 9718 63275061
Superinfection 15.37 10.20 29 204214 2578 63282201
Disease recurrence 15.34 10.20 43 204200 27987 63256792
Hypochloraemia 15.28 10.20 25 204218 1984 63282795
C-reactive protein increased 15.27 10.20 406 203837 94301 63190478
Swelling face 15.25 10.20 288 203955 63187 63221592
Neuroleptic malignant syndrome 15.23 10.20 10 204233 12046 63272733
Product use in unapproved indication 15.22 10.20 449 203794 178631 63106148
Septic shock 15.16 10.20 139 204104 66490 63218289
Hypercholesterolaemia 15.13 10.20 119 204124 21215 63263564
Brain oedema 15.12 10.20 14 204229 14181 63270598
Temperature intolerance 15.08 10.20 5 204238 8959 63275820
Foetal growth restriction 15.02 10.20 3 204240 7550 63277229
C-reactive protein 15.02 10.20 42 204201 4840 63279939
Cardiac valve sclerosis 15.00 10.20 5 204238 24 63284755
Mydriasis 14.99 10.20 10 204233 11946 63272833
Depression 14.93 10.20 500 203743 195992 63088787
Urinary tract infection 14.81 10.20 698 203545 263986 63020793
Pelvic pain 14.79 10.20 13 204230 13506 63271273
Metastases to liver 14.68 10.20 34 204209 23605 63261174
Hip arthroplasty 14.66 10.20 225 204018 47421 63237358
Thyroxine decreased 14.66 10.20 14 204229 639 63284140
Myopathy 14.61 10.20 73 204170 11118 63273661
Therapeutic product effect decreased 14.58 10.20 492 203751 192695 63092084
Feeling jittery 14.53 10.20 13 204230 13390 63271389
Small fibre neuropathy 14.53 10.20 12 204231 451 63284328
Neurologic neglect syndrome 14.49 10.20 29 204214 2692 63282087
Cystitis noninfective 14.48 10.20 17 204226 986 63283793
Pneumocystis jirovecii pneumonia 14.40 10.20 20 204223 16894 63267885
Cleft palate 14.35 10.20 17 204226 995 63283784
Amenorrhoea 14.28 10.20 7 204236 9907 63274872
Erythrodermic psoriasis 14.27 10.20 17 204226 1001 63283778
Blood immunoglobulin M increased 14.27 10.20 18 204225 1125 63283654
Breast cancer 14.25 10.20 94 204149 48289 63236490
Product use issue 14.25 10.20 856 203387 219664 63065115
Traumatic haemorrhage 14.22 10.20 13 204230 561 63284218
Lip blister 14.21 10.20 27 204216 2413 63282366
Neuroglycopenia 14.19 10.20 12 204231 466 63284313
Ocular hyperaemia 14.18 10.20 38 204205 25106 63259673
Anxiety 14.17 10.20 564 203679 216977 63067802
Foot operation 14.12 10.20 3 204240 7228 63277551
Respiratory tract infection 14.11 10.20 77 204166 41406 63243373
Dermatitis contact 14.09 10.20 9 204234 10999 63273780
Pneumonia viral 14.08 10.20 4 204239 7918 63276861
Foetal exposure during pregnancy 14.05 10.20 54 204189 31908 63252871
Intervertebral disc protrusion 14.01 10.20 35 204208 23674 63261105
Muscular weakness 13.99 10.20 503 203740 121850 63162929
Disturbance in social behaviour 13.95 10.20 36 204207 3957 63280822
Oropharyngeal swelling 13.95 10.20 16 204227 905 63283874
Duodenal ulcer perforation 13.81 10.20 373 203870 86836 63197943
Kidney fibrosis 13.76 10.20 23 204220 1858 63282921
Paranoia 13.73 10.20 74 204169 11605 63273174
Carpal tunnel syndrome 13.70 10.20 29 204214 20788 63263991
Renal disorder 13.68 10.20 57 204186 32917 63251862
Sinus arrhythmia 13.54 10.20 20 204223 1453 63283326
Ear infection 13.52 10.20 70 204173 38143 63246636
Menstruation irregular 13.48 10.20 3 204240 7001 63277778
Exposure during pregnancy 13.47 10.20 389 203854 155158 63129621
Splenic vein thrombosis 13.46 10.20 10 204233 321 63284458
Full blood count decreased 13.45 10.20 41 204202 25983 63258796
Rabbit syndrome 13.44 10.20 10 204233 322 63284457
Tooth disorder 13.42 10.20 46 204197 28111 63256668
Anti-cyclic citrullinated peptide antibody 13.39 10.20 50 204193 6708 63278071
Vasodilatation 13.33 10.20 26 204217 2369 63282410
Faecal vomiting 13.33 10.20 13 204230 609 63284170
Thirst 13.29 10.20 84 204159 13957 63270822
Shock haemorrhagic 13.24 10.20 65 204178 9830 63274949
Gastroenteritis viral 13.23 10.20 36 204207 23664 63261115
Obesity 13.20 10.20 151 204092 29801 63254978
Joint range of motion decreased 13.19 10.20 161 204082 32267 63252512
Eyelid bleeding 13.19 10.20 5 204238 37 63284742
Pre-existing condition improved 13.18 10.20 5 204238 8239 63276540
Breast cancer stage I 13.16 10.20 3 204240 6886 63277893
Retinal artery occlusion 13.16 10.20 21 204222 1632 63283147
Nasopharyngitis 13.15 10.20 676 203567 253581 63031198
Skin candida 13.14 10.20 21 204222 1634 63283145
Hemianopia 13.14 10.20 17 204226 1090 63283689
Sinus bradycardia 13.12 10.20 86 204157 14465 63270314
Gastrointestinal ischaemia 13.11 10.20 8 204235 184 63284595
Tachypnoea 13.10 10.20 98 204145 17204 63267575
Tongue biting 13.06 10.20 20 204223 1500 63283279
Dyspnoea 13.04 10.20 2366 201877 658947 62625832
Vascular access complication 13.03 10.20 24 204219 2094 63282685
Breast cancer stage III 13.03 10.20 67 204176 10319 63274460
Increased tendency to bruise 13.00 10.20 9 204234 10543 63274236
Paroxysmal arrhythmia 12.96 10.20 5 204238 39 63284740
Transfusion 12.95 10.20 18 204225 15199 63269580
Haematotoxicity 12.94 10.20 7 204236 9369 63275410
Congestive hepatopathy 12.94 10.20 29 204214 2913 63281866
Ingrowing nail 12.92 10.20 26 204217 2423 63282356
Drug reaction with eosinophilia and systemic symptoms 12.91 10.20 166 204077 33670 63251109
Joint swelling 12.89 10.20 894 203349 326772 62958007
Eye infarction 12.86 10.20 5 204238 40 63284739
Middle insomnia 12.85 10.20 13 204230 12630 63272149
Aortic valve stenosis 12.84 10.20 31 204212 3268 63281511
Hallucination, visual 12.80 10.20 106 204137 19192 63265587
Basal ganglia haemorrhage 12.78 10.20 13 204230 641 63284138
Bone density decreased 12.72 10.20 17 204226 14595 63270184
SARS-CoV-2 test positive 12.69 10.20 5 204238 8051 63276728
Arteriosclerosis 12.68 10.20 65 204178 10001 63274778
Coma 12.67 10.20 139 204104 64225 63220554
Epstein-Barr virus infection 12.67 10.20 5 204238 8045 63276734
Osmotic demyelination syndrome 12.63 10.20 13 204230 650 63284129
Bronchopulmonary aspergillosis 12.59 10.20 6 204237 8629 63276150
Acute abdomen 12.55 10.20 20 204223 1553 63283226
Tension 12.54 10.20 30 204213 3145 63281634
Influenza like illness 12.50 10.20 146 204097 66678 63218101
Adrenocortical carcinoma 12.44 10.20 5 204238 44 63284735
Hypertelorism 12.38 10.20 11 204232 457 63284322
Hypersensitivity vasculitis 12.28 10.20 35 204208 4077 63280702
Micturition disorder 12.28 10.20 26 204217 2512 63282267
Vitamin D decreased 12.27 10.20 9 204234 10233 63274546
Scoliosis 12.26 10.20 5 204238 7883 63276896
Tardive dyskinesia 12.25 10.20 6 204237 8496 63276283
Musculoskeletal deformity 12.21 10.20 22 204221 1887 63282892
Red cell distribution width decreased 12.21 10.20 23 204220 2042 63282737
Prescription drug used without a prescription 12.20 10.20 25 204218 2361 63282418
Hip fracture 12.20 10.20 51 204192 29423 63255356
Pregnancy 12.19 10.20 69 204174 36767 63248012
Uraemic gastropathy 12.16 10.20 3 204240 3 63284776
Gastrointestinal angiodysplasia 12.12 10.20 11 204232 470 63284309
Skin pressure mark 12.03 10.20 4 204239 19 63284760
Sensory level abnormal 12.03 10.20 7 204236 147 63284632
Mean cell volume decreased 12.02 10.20 34 204209 3944 63280835
Abdominal pain lower 12.02 10.20 131 204112 25547 63259232
Peripartum cardiomyopathy 11.99 10.20 7 204236 148 63284631
Eye pain 11.98 10.20 62 204181 33792 63250987
Nervousness 11.97 10.20 55 204188 30924 63253855
Coronary artery stenosis 11.93 10.20 38 204205 4706 63280073
Malignant neoplasm of unknown primary site 11.93 10.20 9 204234 296 63284483
Accidental overdose 11.89 10.20 121 204122 23188 63261591
Ketoacidosis 11.87 10.20 36 204207 4342 63280437
Anal paraesthesia 11.87 10.20 4 204239 20 63284759
Genital paraesthesia 11.87 10.20 4 204239 20 63284759
Myoglobinaemia 11.87 10.20 4 204239 20 63284759
Lymphoma 11.86 10.20 13 204230 12174 63272605
Sleep disorder due to general medical condition, insomnia type 11.85 10.20 109 204134 52108 63232671
Insulin-requiring type 2 diabetes mellitus 11.82 10.20 6 204237 95 63284684
Oxygen saturation decreased 11.82 10.20 207 204036 88378 63196401
Aphasia 11.80 10.20 160 204083 32840 63251939
Oesophagitis haemorrhagic 11.80 10.20 11 204232 487 63284292
Hyperparathyroidism primary 11.79 10.20 10 204233 390 63284389
Tooth infection 11.76 10.20 25 204218 17895 63266884
Rheumatoid factor positive 11.70 10.20 355 203888 84051 63200728
Euglycaemic diabetic ketoacidosis 11.69 10.20 32 204211 3642 63281137
Drug dependence 11.66 10.20 40 204203 24443 63260336
Genital infection female 11.66 10.20 6 204237 98 63284681
Live birth 11.65 10.20 130 204113 25500 63259279
Cerebral haematoma 11.64 10.20 32 204211 3651 63281128
Aortic valve incompetence 11.61 10.20 44 204199 5944 63278835
Decreased activity 11.59 10.20 3 204240 6317 63278462
Brain compression 11.58 10.20 10 204233 400 63284379
Product dose omission in error 11.55 10.20 5 204238 7607 63277172
Parosmia 11.54 10.20 45 204198 6161 63278618
Aortic arteriosclerosis 11.53 10.20 45 204198 6164 63278615
Acute respiratory distress syndrome 11.52 10.20 38 204205 23496 63261283
Oral discharge 11.51 10.20 7 204236 160 63284619
Delusion 11.49 10.20 13 204230 12004 63272775
Pseudomyopia 11.47 10.20 5 204238 55 63284724
Foot fracture 11.44 10.20 39 204204 23875 63260904
Hereditary angioedema 11.42 10.20 5 204238 7557 63277222
Catarrh 11.41 10.20 19 204224 1530 63283249
Demyelination 11.40 10.20 4 204239 6916 63277863
Gastric cyst 11.39 10.20 6 204237 103 63284676
Ureteric stenosis 11.35 10.20 12 204231 619 63284160
Sensitisation 11.29 10.20 30 204213 3356 63281423
Skin fissures 11.24 10.20 12 204231 11376 63273403
Lung disorder 11.24 10.20 271 203972 61990 63222789
Concussion 11.24 10.20 8 204235 9236 63275543
Intentional product use issue 11.21 10.20 511 203732 127381 63157398
Toxic neuropathy 11.21 10.20 10 204233 418 63284361
Sweat gland tumour 11.19 10.20 6 204237 107 63284672
Continuous haemodiafiltration 11.18 10.20 15 204228 996 63283783
Anaphylactoid shock 11.13 10.20 9 204234 328 63284451
Mouth swelling 11.05 10.20 37 204206 4703 63280076
Pruritus 11.00 10.20 1007 203236 360446 62924333
Myocardial ischaemia 11.00 10.20 75 204168 12784 63271995
Nodal arrhythmia 10.99 10.20 16 204227 1147 63283632
Oedema due to hepatic disease 10.95 10.20 3 204240 6 63284773
Fibrinous bronchitis 10.95 10.20 3 204240 6 63284773
Stillbirth 10.95 10.20 4 204239 6746 63278033
Adverse reaction 10.94 10.20 10 204233 10193 63274586
Genital lesion 10.93 10.20 8 204235 251 63284528
Anaemia macrocytic 10.91 10.20 30 204213 3424 63281355
Skin discolouration 10.89 10.20 74 204169 37754 63247025
Intracardiac thrombus 10.87 10.20 24 204219 2386 63282393
Vascular pseudoaneurysm ruptured 10.87 10.20 5 204238 63 63284716
Coma acidotic 10.85 10.20 6 204237 114 63284665
Nasal polyps 10.82 10.20 3 204240 6036 63278743
Insomnia 10.80 10.20 574 203669 214678 63070101
Vulval cancer 10.80 10.20 13 204230 774 63284005
Hypertension 10.79 10.20 1041 203202 278262 63006517
Bradykinesia 10.79 10.20 39 204204 5149 63279630
Hydronephrosis 10.79 10.20 11 204232 10651 63274128
Gastrooesophageal reflux disease 10.77 10.20 230 204013 95409 63189370
Subdural haematoma 10.76 10.20 81 204162 14247 63270532
Diffuse vasculitis 10.74 10.20 4 204239 28 63284751
Acquired diaphragmatic eventration 10.74 10.20 10 204233 442 63284337
Bone marrow failure 10.73 10.20 53 204190 29237 63255542
Aplastic anaemia 10.72 10.20 9 204234 9560 63275219
Periorbital haematoma 10.71 10.20 13 204230 781 63283998
Oropharyngeal pain 10.70 10.20 227 204016 94260 63190519
Systemic lupus erythematosus 10.65 10.20 795 203448 208123 63076656
Dysuria 10.64 10.20 160 204083 33578 63251201
Urethral prolapse 10.64 10.20 3 204240 7 63284772
Relapsing multiple sclerosis 10.61 10.20 7 204236 185 63284594
Gastritis erosive 10.59 10.20 43 204200 5996 63278783
Left ventricular enlargement 10.59 10.20 5 204238 67 63284712
Drop attacks 10.58 10.20 12 204231 670 63284109
Sputum discoloured 10.57 10.20 23 204220 16324 63268455
Suffocation feeling 10.54 10.20 17 204226 1333 63283446
Disturbance in attention 10.49 10.20 177 204066 38012 63246767
Hand deformity 10.49 10.20 620 203623 158837 63125942
Muscle twitching 10.47 10.20 103 204140 19565 63265214
Back disorder 10.45 10.20 12 204231 11005 63273774
Blood cholesterol decreased 10.43 10.20 14 204229 930 63283849
Premature labour 10.43 10.20 15 204228 12489 63272290
Normal newborn 10.43 10.20 7 204236 8334 63276445
Knee arthroplasty 10.42 10.20 238 204005 53968 63230811
Coronary arterial stent insertion 10.40 10.20 26 204217 2803 63281976
Hypogammaglobulinaemia 10.38 10.20 5 204238 7150 63277629
Peripheral swelling 10.38 10.20 726 203517 265216 63019563
Blood osmolarity abnormal 10.36 10.20 3 204240 8 63284771
Gastrointestinal haemorrhage 10.35 10.20 338 203905 80838 63203941
Haematocrit decreased 10.33 10.20 79 204164 39261 63245518
Dementia 10.28 10.20 99 204144 18695 63266084
Nephrolithiasis 10.25 10.20 86 204157 41898 63242881
Device leakage 10.24 10.20 5 204238 7091 63277688

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 641.21 10.69 3038 165829 301950 34486114
Death 537.50 10.69 683 168184 397366 34390698
General physical health deterioration 441.87 10.69 1493 167374 126776 34661288
Angioedema 392.46 10.69 672 168195 36702 34751362
Hyperkalaemia 385.43 10.69 959 167908 68430 34719634
Drug ineffective 371.80 10.69 1062 167805 455689 34332375
Off label use 325.54 10.69 997 167870 418527 34369537
Syncope 297.57 10.69 1045 167822 90406 34697658
Hypertensive crisis 274.94 10.69 271 168596 8480 34779584
Bradycardia 247.16 10.69 864 168003 74554 34713510
Hypotension 231.46 10.69 1845 167022 219804 34568260
Completed suicide 230.15 10.69 93 168774 98075 34689989
Cardiac failure 217.21 10.69 945 167922 90303 34697761
Product dose omission issue 206.87 10.69 165 168702 119546 34668518
Product prescribing error 203.17 10.69 383 168484 22544 34765520
Toxicity to various agents 202.36 10.69 415 168452 199947 34588117
Febrile neutropenia 187.74 10.69 231 168636 136618 34651446
Angina pectoris 187.31 10.69 446 168421 30917 34757147
Presyncope 182.22 10.69 329 168538 18730 34769334
Dyspnoea 167.67 10.69 2650 166217 374132 34413932
Drug interaction 166.54 10.69 1745 167122 224201 34563863
Swollen tongue 165.72 10.69 272 168595 14333 34773731
Disease progression 162.84 10.69 169 168698 107908 34680156
Pneumonia 148.32 10.69 1085 167782 361542 34426522
Myocardial infarction 147.54 10.69 1046 167821 120039 34668025
Neutropenia 146.37 10.69 339 168528 156439 34631625
Platelet count decreased 144.14 10.69 222 168645 119495 34668569
Atrial fibrillation 139.75 10.69 1041 167826 121352 34666712
Orthostatic hypotension 136.18 10.69 351 168516 25568 34762496
Coronary artery disease 132.69 10.69 523 168344 47782 34740282
Ejection fraction decreased 126.01 10.69 283 168584 18871 34769193
Lip swelling 122.34 10.69 252 168615 15828 34772236
Product use in unapproved indication 117.92 10.69 244 168623 117255 34670809
Dizziness 117.34 10.69 1589 167278 216932 34571132
Drug abuse 115.24 10.69 188 168679 98908 34689156
White blood cell count decreased 114.85 10.69 177 168690 95268 34692796
Neuropathy peripheral 114.67 10.69 140 168727 83123 34704941
Tongue oedema 113.60 10.69 103 168764 2894 34785170
Acute myocardial infarction 113.26 10.69 537 168330 53182 34734882
Oedema peripheral 106.00 10.69 962 167905 118850 34669214
Hypoglycaemia 104.33 10.69 531 168336 54109 34733955
Haematochezia 103.10 10.69 472 168395 46062 34742002
Circulatory collapse 100.47 10.69 275 168592 20763 34767301
Product monitoring error 99.16 10.69 114 168753 4267 34783797
Pyrexia 96.01 10.69 1088 167779 331925 34456139
Acute coronary syndrome 92.32 10.69 203 168664 13342 34774722
Lactic acidosis 89.49 10.69 369 168498 34403 34753661
Sopor 87.43 10.69 186 168681 11950 34776114
Melaena 86.03 10.69 369 168498 35011 34753053
Hospitalisation 85.62 10.69 89 168778 56813 34731251
Loss of consciousness 84.21 10.69 685 168182 81982 34706082
Treatment failure 82.30 10.69 63 168804 46634 34741430
Arrhythmia 82.15 10.69 367 168500 35441 34752623
Electrolyte imbalance 81.78 10.69 201 168666 14211 34773853
Fall 80.56 10.69 1402 167465 201483 34586581
Cardiac failure chronic 80.44 10.69 140 168727 7739 34780325
Hyponatraemia 80.38 10.69 678 168189 82013 34706051
Respiratory failure 79.46 10.69 264 168603 108308 34679756
Hepatojugular reflux 78.52 10.69 44 168823 557 34787507
Hepatic function abnormal 77.99 10.69 60 168807 44303 34743761
Vertigo 77.94 10.69 286 168581 25250 34762814
Exercise tolerance decreased 77.63 10.69 110 168757 5088 34782976
Drug dependence 75.46 10.69 13 168854 24204 34763860
Ventricular arrhythmia 75.30 10.69 112 168755 5416 34782648
Drug hypersensitivity 75.16 10.69 174 168693 80355 34707709
Mitral valve incompetence 75.03 10.69 199 168668 14744 34773320
Cytomegalovirus infection 73.22 10.69 18 168849 26117 34761947
Plasma cell myeloma 71.21 10.69 59 168808 41978 34746086
Palatal oedema 71.03 10.69 47 168820 816 34787248
Malignant neoplasm progression 70.12 10.69 206 168661 87840 34700224
Dyspnoea exertional 70.00 10.69 402 168465 42877 34745187
Rash 69.58 10.69 714 168153 222038 34566026
COVID-19 68.08 10.69 173 168694 77377 34710687
Dyspnoea at rest 67.79 10.69 88 168779 3740 34784324
Sepsis 66.53 10.69 501 168366 166060 34622004
Systemic infection 65.90 10.69 102 168765 5110 34782954
Labelled drug-drug interaction medication error 65.17 10.69 189 168678 14750 34773314
Neutrophil count decreased 64.13 10.69 92 168775 51012 34737052
Pallor 63.68 10.69 268 168599 25212 34762852
Hypoxia 62.64 10.69 106 168761 54989 34733075
Drug ineffective for unapproved indication 61.45 10.69 19 168848 23696 34764368
Electrocardiogram abnormal 61.23 10.69 137 168730 9110 34778954
Haematuria 60.56 10.69 432 168435 49634 34738430
Cerebral haemorrhage 59.46 10.69 329 168538 34608 34753456
Palpitations 59.26 10.69 363 168504 39623 34748441
Occult blood 58.98 10.69 42 168825 826 34787238
Sinusitis 58.69 10.69 68 168799 41334 34746730
Myalgia 58.63 10.69 643 168224 83467 34704597
Tricuspid valve incompetence 58.46 10.69 139 168728 9621 34778443
Left ventricular dysfunction 58.30 10.69 141 168726 9866 34778198
Full blood count decreased 57.94 10.69 9 168858 18079 34769985
Congenital hiatus hernia 57.72 10.69 41 168826 803 34787261
Ventricular hypokinesia 57.13 10.69 99 168768 5453 34782611
Intentional product use issue 56.00 10.69 129 168738 59687 34728377
Cytokine release syndrome 54.66 10.69 21 168846 22856 34765208
Erectile dysfunction 53.09 10.69 219 168648 20418 34767646
Urogenital haemorrhage 52.82 10.69 37 168830 708 34787356
Glomerular filtration rate decreased 52.76 10.69 160 168707 12801 34775263
Computerised tomogram coronary artery abnormal 52.19 10.69 24 168843 193 34787871
Brain stem stroke 51.30 10.69 27 168840 299 34787765
Coronary artery stenosis 50.26 10.69 130 168737 9486 34778578
Rhabdomyolysis 49.77 10.69 526 168341 67637 34720427
Product use issue 49.53 10.69 149 168718 63067 34724997
Mental status changes 49.33 10.69 67 168800 38016 34750048
Drug intolerance 49.16 10.69 137 168730 59433 34728631
Systolic dysfunction 49.12 10.69 63 168804 2645 34785419
Therapeutic product effect incomplete 48.94 10.69 107 168760 50434 34737630
Drug resistance 48.26 10.69 33 168834 25894 34762170
Therapeutic product effect decreased 48.24 10.69 58 168809 34685 34753379
Dehydration 47.20 10.69 886 167981 129083 34658981
Ischaemic stroke 46.42 10.69 193 168674 18057 34770007
Sinus bradycardia 46.33 10.69 153 168714 12810 34775254
Respiratory depression 45.88 10.69 11 168856 16234 34771830
Electrocardiogram Q wave abnormal 45.79 10.69 28 168839 421 34787643
Inferior vena cava dilatation 45.35 10.69 34 168833 726 34787338
Therapeutic drug monitoring analysis not performed 44.65 10.69 30 168837 535 34787529
International normalised ratio increased 43.83 10.69 384 168483 46943 34741121
Stomatitis 43.69 10.69 87 168780 42427 34745637
Anaemia 43.69 10.69 1454 167413 231881 34556183
Bundle branch block left 43.48 10.69 92 168775 5887 34782177
Degenerative mitral valve disease 43.37 10.69 23 168844 259 34787805
Drug withdrawal syndrome 42.95 10.69 21 168846 19813 34768251
Congestive cardiomyopathy 42.88 10.69 105 168762 7405 34780659
Helicobacter gastritis 42.05 10.69 40 168827 1196 34786868
Musculoskeletal pain 40.52 10.69 279 168588 31684 34756380
Cardio-respiratory arrest 39.99 10.69 135 168732 55138 34732926
Liver disorder 39.84 10.69 61 168806 32936 34755128
Aspergillus infection 39.47 10.69 6 168861 12248 34775816
Medication error 39.08 10.69 234 168633 25331 34762733
Rectal haemorrhage 39.06 10.69 330 168537 39919 34748145
Potentiating drug interaction 39.03 10.69 79 168788 4898 34783166
Nocturia 38.74 10.69 123 168744 10087 34777977
Naevus flammeus 38.66 10.69 19 168848 180 34787884
Blood pressure increased 38.59 10.69 619 168248 87483 34700581
Hyponatraemic syndrome 38.48 10.69 19 168848 182 34787882
Chest pain 38.03 10.69 840 168027 125922 34662142
Antidepressant drug level above therapeutic 37.65 10.69 20 168847 226 34787838
Cholestasis 37.65 10.69 241 168626 26707 34761357
Blood creatinine increased 37.47 10.69 656 168211 94320 34693744
Infusion related reaction 37.43 10.69 131 168736 52926 34735138
Hypercholesterolaemia 37.40 10.69 110 168757 8652 34779412
Confusional state 37.34 10.69 936 167931 143224 34644840
Lip oedema 37.12 10.69 54 168813 2559 34785505
Pancreatitis acute 37.08 10.69 248 168619 27893 34760171
Graft versus host disease 36.88 10.69 4 168863 10565 34777499
Bacteraemia 36.82 10.69 25 168842 19692 34768372
Intentional product misuse 36.81 10.69 106 168761 45505 34742559
Bradyarrhythmia 36.68 10.69 49 168818 2142 34785922
Carotid artery stenosis 36.23 10.69 77 168790 4942 34783122
Hemiplegia 36.17 10.69 94 168773 6878 34781186
Constipation 36.06 10.69 456 168411 136526 34651538
Atrioventricular block complete 36.03 10.69 113 168754 9206 34778858
Bronchopulmonary aspergillosis 35.79 10.69 13 168854 14646 34773418
Therapy interrupted 35.44 10.69 11 168856 13686 34774378
Bone marrow failure 35.39 10.69 54 168813 29199 34758865
Wrong technique in product usage process 34.99 10.69 76 168791 35910 34752154
Deep vein thrombosis 34.97 10.69 179 168688 65069 34722995
Hemiparesis 34.89 10.69 160 168707 15618 34772446
Pulmonary vascular disorder 34.78 10.69 28 168839 666 34787398
Basilar artery thrombosis 34.64 10.69 19 168848 230 34787834
Haematoma 34.55 10.69 227 168640 25378 34762686
Abnormal behaviour 34.33 10.69 42 168825 24927 34763137
Disseminated intravascular coagulation 34.09 10.69 33 168834 21783 34766281
Blood pressure diastolic decreased 34.00 10.69 109 168758 8985 34779079
Myelosuppression 33.92 10.69 26 168841 19239 34768825
Obstructive pancreatitis 33.79 10.69 26 168841 578 34787486
Thrombocytopenia 33.76 10.69 541 168326 155706 34632358
Ventricular tachycardia 33.68 10.69 232 168635 26347 34761717
Type 2 diabetes mellitus 33.56 10.69 160 168707 15872 34772192
Cerebral haematoma 33.55 10.69 71 168796 4544 34783520
Haemodialysis complication 33.48 10.69 14 168853 87 34787977
Infective exacerbation of chronic obstructive airways disease 33.48 10.69 43 168824 1808 34786256
Analgesic drug level above therapeutic 33.16 10.69 20 168847 293 34787771
Cold sweat 33.15 10.69 115 168752 9872 34778192
Orthopnoea 33.11 10.69 75 168792 5028 34783036
Normocytic anaemia 32.66 10.69 48 168819 2296 34785768
Hiatus hernia 32.65 10.69 96 168771 7549 34780515
Therapy partial responder 32.65 10.69 4 168863 9612 34778452
Shone complex 32.33 10.69 13 168854 72 34787992
No adverse event 32.12 10.69 38 168829 22889 34765175
Nasopharyngitis 32.07 10.69 202 168665 69766 34718298
Pathogen resistance 32.06 10.69 4 168863 9478 34778586
Metabolic acidosis 31.84 10.69 337 168530 43343 34744721
Carotid arteriosclerosis 31.79 10.69 42 168825 1816 34786248
Cardiovascular insufficiency 31.79 10.69 40 168827 1647 34786417
Jaundice 31.78 10.69 263 168604 31619 34756445
Wound 31.59 10.69 149 168718 14715 34773349
Insomnia 31.57 10.69 335 168532 103572 34684492
Immune reconstitution inflammatory syndrome 31.38 10.69 3 168864 8756 34779308
Adverse event 31.34 10.69 27 168840 18850 34769214
Hyperthyroidism 31.11 10.69 117 168750 10449 34777615
Pharyngeal oedema 30.83 10.69 81 168786 5966 34782098
Failure to thrive 30.67 10.69 3 168864 8598 34779466
Pancytopenia 30.46 10.69 303 168564 94854 34693210
Acute respiratory distress syndrome 30.40 10.69 49 168818 25920 34762144
Back pain 29.64 10.69 412 168455 121377 34666687
Swelling face 28.88 10.69 201 168666 22904 34765160
Cardiac aneurysm 28.80 10.69 29 168838 931 34787133
N-terminal prohormone brain natriuretic peptide increased 28.70 10.69 49 168818 2666 34785398
Angina unstable 28.67 10.69 122 168745 11531 34776533
Blood creatine phosphokinase increased 28.56 10.69 337 168530 44520 34743544
Cytopenia 28.27 10.69 13 168854 12710 34775354
Arthralgia 28.27 10.69 616 168251 169425 34618639
Mucosal haemorrhage 28.22 10.69 37 168830 1588 34786476
Vertebral osteophyte 28.11 10.69 11 168856 56 34788008
Dry skin 28.06 10.69 69 168798 31218 34756846
Tachyarrhythmia 27.97 10.69 57 168810 3551 34784513
Atrioventricular block 27.77 10.69 94 168773 7969 34780095
Aorta hypoplasia 27.75 10.69 12 168855 82 34787982
Anxiety 27.66 10.69 327 168540 99101 34688963
Mucosal inflammation 27.48 10.69 95 168772 38527 34749537
Ocular myasthenia 27.41 10.69 16 168851 220 34787844
Decreased appetite 27.31 10.69 604 168263 165788 34622276
Mitral valve disease 27.31 10.69 34 168833 1385 34786679
Neurotoxicity 27.27 10.69 28 168839 17982 34770082
Chronotropic incompetence 27.04 10.69 8 168859 13 34788051
Benign prostatic hyperplasia 27.03 10.69 140 168727 14355 34773709
Nicotine dependence 26.95 10.69 23 168844 595 34787469
Seizure 26.86 10.69 351 168516 104506 34683558
Respiratory arrest 26.62 10.69 60 168807 27983 34760081
Heart rate decreased 26.55 10.69 252 168615 31493 34756571
Haematotoxicity 26.42 10.69 4 168863 8190 34779874
Cardiac septal hypertrophy 26.36 10.69 17 168850 282 34787782
Akathisia 26.05 10.69 4 168863 8105 34779959
Appendicitis 26.05 10.69 20 168847 14787 34773277
Aspartate aminotransferase increased 26.02 10.69 206 168661 67577 34720487
Appendicolith 25.97 10.69 5 168862 8596 34779468
Actinic elastosis 25.86 10.69 10 168857 49 34788015
Diabetic foetopathy 25.84 10.69 15 168852 204 34787860
Rales 25.51 10.69 105 168762 9778 34778286
Cytomegalovirus viraemia 25.45 10.69 3 168864 7427 34780637
Exposure during pregnancy 25.32 10.69 6 168861 8928 34779136
Depressed mood 25.30 10.69 170 168697 19147 34768917
Cranial sutures widening 25.21 10.69 11 168856 77 34787987
Cough 25.15 10.69 924 167943 149216 34638848
Gastritis erosive 24.87 10.69 74 168793 5858 34782206
Multiple organ dysfunction syndrome 24.84 10.69 243 168624 76323 34711741
Pneumonia aspiration 24.76 10.69 111 168756 41792 34746272
Nephroangiosclerosis 24.66 10.69 14 168853 182 34787882
Mouth breathing 24.63 10.69 11 168856 82 34787982
Blood bilirubin abnormal 24.41 10.69 24 168843 748 34787316
Hypersomnia 24.16 10.69 15 168852 12392 34775672
Illness 24.15 10.69 18 168849 13511 34774553
Infection 24.14 10.69 302 168565 90613 34697451
Influenza 24.00 10.69 141 168726 49525 34738539
Hypoaesthesia eye 23.98 10.69 8 168859 23 34788041
Post procedural haematoma 23.84 10.69 33 168834 1493 34786571
Staphylococcal infection 23.70 10.69 80 168787 32680 34755384
Helicobacter test positive 23.66 10.69 25 168842 850 34787214
Renal impairment 23.66 10.69 611 168256 93902 34694162
Blood pressure systolic decreased 23.66 10.69 61 168806 4442 34783622
Brain scan abnormal 23.55 10.69 25 168842 855 34787209
Haemophagocytic lymphohistiocytosis 23.50 10.69 17 168850 12956 34775108
Therapeutic response unexpected 23.24 10.69 9 168858 9748 34778316
Haematemesis 23.18 10.69 220 168647 27491 34760573
Foetal exposure during pregnancy 23.07 10.69 100 168767 38001 34750063
Upper respiratory tract infection 23.06 10.69 82 168785 32977 34755087
Embolic stroke 23.05 10.69 60 168807 4394 34783670
Therapeutic response decreased 23.01 10.69 69 168798 29244 34758820
Mouth swelling 23.01 10.69 36 168831 1820 34786244
Supravalvular aortic stenosis 22.97 10.69 9 168858 46 34788018
Gamma-glutamyltransferase increased 22.95 10.69 229 168638 29002 34759062
Phalangeal hypoplasia 22.92 10.69 10 168857 70 34787994
Therapy cessation 22.86 10.69 29 168838 16944 34771120
Polyuria 22.85 10.69 92 168775 8482 34779582
Anal haemorrhage 22.74 10.69 43 168824 2535 34785529
Blood pressure systolic increased 22.70 10.69 189 168678 22763 34765301
Injection site pain 22.64 10.69 104 168763 38901 34749163
Ascites 22.62 10.69 132 168735 46439 34741625
Fluid intake reduced 22.48 10.69 53 168814 3648 34784416
Glomerular filtration rate 22.40 10.69 11 168856 104 34787960
Cerebral artery thrombosis 22.38 10.69 23 168844 757 34787307
Adverse drug reaction 22.37 10.69 70 168797 29272 34758792
Epiglottic oedema 22.31 10.69 13 168854 178 34787886
Eye injury 22.27 10.69 24 168843 835 34787229
Pneumonia bacterial 22.24 10.69 15 168852 11857 34776207
Diabetic ketoacidosis 22.03 10.69 156 168711 17876 34770188
Hypoalbuminaemia 21.99 10.69 16 168851 12158 34775906
Thrombosis 21.94 10.69 148 168719 50310 34737754
Trigger finger 21.91 10.69 24 168843 851 34787213
Loss of proprioception 21.90 10.69 17 168850 383 34787681
Malignant spinal cord compression 21.90 10.69 12 168855 145 34787919
Epstein-Barr virus infection 21.87 10.69 5 168862 7623 34780441
Hypertrophy 21.84 10.69 18 168849 443 34787621
Vasculitic rash 21.78 10.69 25 168842 934 34787130
Red blood cell abnormality 21.75 10.69 17 168850 387 34787677
Stenosis 21.74 10.69 31 168836 1442 34786622
Device leakage 21.69 10.69 3 168864 6572 34781492
Euglycaemic diabetic ketoacidosis 21.63 10.69 48 168819 3174 34784890
Low density lipoprotein abnormal 21.53 10.69 16 168851 337 34787727
Carcinogenicity 21.52 10.69 9 168858 56 34788008
Pneumocystis jirovecii pneumonia 21.41 10.69 39 168828 19671 34768393
Camptocormia 21.20 10.69 12 168855 155 34787909
Upper motor neurone lesion 21.12 10.69 11 168856 119 34787945
Duodenitis 20.98 10.69 61 168806 4767 34783297
Mitral valve hypoplasia 20.89 10.69 8 168859 38 34788026
Cerebrovascular accident 20.85 10.69 547 168320 84264 34703800
C-reactive protein abnormal 20.80 10.69 8 168859 8702 34779362
Duodenal ulcer perforation 20.72 10.69 32 168835 1600 34786464
Unevaluable event 20.68 10.69 84 168783 32506 34755558
Anuria 20.56 10.69 102 168765 10283 34777781
Pain 20.47 10.69 795 168072 203880 34584184
Septic shock 20.45 10.69 235 168632 71599 34716465
Dermatitis allergic 20.42 10.69 76 168791 6754 34781310
Hypogammaglobulinaemia 20.42 10.69 6 168861 7734 34780330
Neoplasm progression 20.41 10.69 52 168815 23248 34764816
Macrophages increased 20.37 10.69 12 168855 168 34787896
Patent ductus arteriosus 20.34 10.69 48 168819 3306 34784758
Oedema mouth 20.29 10.69 28 168839 1263 34786801
Oral neoplasm 20.28 10.69 9 168858 66 34787998
Eczema nummular 20.21 10.69 11 168856 131 34787933
Product storage error 20.17 10.69 7 168860 8115 34779949
Vocal cord inflammation 20.16 10.69 9 168858 67 34787997
Bacterial infection 20.16 10.69 32 168835 17031 34771033
Tendon rupture 20.11 10.69 77 168790 6935 34781129
Diastolic dysfunction 20.06 10.69 71 168796 6156 34781908
Heart rate irregular 20.04 10.69 138 168729 15669 34772395
Diarrhoea 20.03 10.69 1617 167250 388295 34399769
Dysarthria 19.84 10.69 256 168611 34526 34753538
Ventricular enlargement 19.81 10.69 20 168847 644 34787420
Diabetes mellitus inadequate control 19.79 10.69 122 168745 13342 34774722
Left atrial dilatation 19.77 10.69 35 168832 1961 34786103
Ventricular dysfunction 19.60 10.69 52 168815 3853 34784211
Pancreatitis necrotising 19.55 10.69 42 168825 2716 34785348
Laryngeal cleft 19.49 10.69 6 168861 12 34788052
Gravitational oedema 19.41 10.69 20 168847 660 34787404
Low cardiac output syndrome 19.41 10.69 19 168848 589 34787475
Transplant rejection 19.35 10.69 13 168854 10298 34777766
Sudden cardiac death 19.30 10.69 50 168817 3651 34784413
Face oedema 19.29 10.69 108 168759 11408 34776656
Precancerous skin lesion 19.25 10.69 19 168848 595 34787469
Sinus arrest 19.19 10.69 32 168835 1708 34786356
Band neutrophil percentage decreased 19.17 10.69 6 168861 13 34788051
Blood potassium increased 19.16 10.69 141 168726 16354 34771710
Laboratory test abnormal 19.05 10.69 44 168823 20347 34767717
Anastomotic infection 18.98 10.69 10 168857 111 34787953
Injection site reaction 18.91 10.69 21 168846 13012 34775052
Left ventricular enlargement 18.88 10.69 20 168847 682 34787382
Encephalopathy 18.86 10.69 97 168770 35222 34752842
Transient ischaemic attack 18.71 10.69 210 168657 27403 34760661
Contraindicated product administered 18.70 10.69 172 168695 21309 34766755
Immune-mediated myositis 18.69 10.69 35 168832 2048 34786016
Melanoderma 18.67 10.69 11 168856 154 34787910
Abnormal weight gain 18.67 10.69 24 168843 1010 34787054
Hyperglycaemia 18.65 10.69 281 168586 39199 34748865
Injection site erythema 18.61 10.69 30 168837 15869 34772195
Epistaxis 18.40 10.69 389 168478 57862 34730202
Nephrotic syndrome 18.38 10.69 77 168790 7226 34780838
Genital herpes simplex 18.38 10.69 10 168857 119 34787945
Post-traumatic amnestic disorder 18.34 10.69 8 168859 56 34788008
Type V hyperlipidaemia 18.33 10.69 21 168846 783 34787281
Agitation 18.26 10.69 183 168684 57216 34730848
Xyphoid retraction 18.19 10.69 11 168856 162 34787902
Mucosal dryness 18.17 10.69 27 168840 1304 34786760
Myositis 18.14 10.69 110 168757 11960 34776104
Pericardial disease 18.11 10.69 16 168851 434 34787630
Malignant melanoma in situ 18.02 10.69 31 168836 1697 34786367
Renal-limited thrombotic microangiopathy 17.98 10.69 9 168858 89 34787975
Ketoacidosis 17.85 10.69 53 168814 4190 34783874
Pemphigoid 17.78 10.69 86 168781 8580 34779484
Pulmonary alveolar haemorrhage 17.77 10.69 7 168860 7505 34780559
Perineal pain 17.72 10.69 21 168846 812 34787252
Interstitial lung disease 17.65 10.69 216 168651 65066 34722998
Arterial spasm 17.64 10.69 9 168858 93 34787971
Product administration error 17.47 10.69 137 168730 16207 34771857
Hypercreatinaemia 17.45 10.69 11 168856 175 34787889
Dystonia 17.42 10.69 16 168851 10829 34777235
Cellulitis 17.19 10.69 168 168699 52783 34735281
Enlarged uvula 17.11 10.69 12 168855 230 34787834
Accidental exposure to product 17.11 10.69 22 168845 12780 34775284
Myocardial ischaemia 17.03 10.69 143 168724 17265 34770799
Lordosis 16.94 10.69 14 168853 346 34787718
Urinary hesitation 16.88 10.69 40 168827 2762 34785302
Polycystic liver disease 16.85 10.69 9 168858 103 34787961
Fracture displacement 16.85 10.69 9 168858 103 34787961
Arteriosclerotic gangrene 16.72 10.69 8 168859 71 34787993
Hyperammonaemia 16.68 10.69 5 168862 6362 34781702
Tumour lysis syndrome 16.60 10.69 36 168831 17023 34771041
Pharyngeal swelling 16.57 10.69 35 168832 2237 34785827
Jealous delusion 16.48 10.69 13 168854 300 34787764
Gastritis haemorrhagic 16.42 10.69 27 168840 1424 34786640
Venoocclusive liver disease 16.41 10.69 9 168858 7957 34780107
Resuscitation 16.40 10.69 27 168840 1426 34786638
Bleeding time prolonged 16.39 10.69 18 168849 640 34787424
Poisoning 16.35 10.69 21 168846 12205 34775859
Tongue disorder 16.34 10.69 3 168864 5336 34782728
Paraesthesia oral 16.32 10.69 51 168816 4146 34783918
Clostridium difficile colitis 16.32 10.69 32 168835 15698 34772366
Surgery 16.30 10.69 27 168840 14130 34773934
Flagellate dermatitis 16.26 10.69 8 168859 76 34787988
Foetal disorder 16.23 10.69 20 168847 806 34787258
Physical examination abnormal 16.23 10.69 13 168854 307 34787757
Nasal congestion 16.21 10.69 57 168810 23000 34765064
Carcinoma in situ of skin 16.17 10.69 8 168859 77 34787987
Miller Fisher syndrome 16.12 10.69 9 168858 113 34787951
Irritability 16.07 10.69 63 168804 24627 34763437
Anaemia macrocytic 15.91 10.69 41 168826 2985 34785079
Palmar-plantar erythrodysaesthesia syndrome 15.89 10.69 36 168831 16759 34771305
Lymphocyte count decreased 15.85 10.69 56 168811 22566 34765498
Malnutrition 15.82 10.69 23 168844 12686 34775378
Granulocytopenia 15.73 10.69 6 168861 6561 34781503
Chills 15.73 10.69 286 168581 80757 34707307
Chronic kidney disease 15.65 10.69 283 168584 40927 34747137
Cardiogenic shock 15.64 10.69 197 168670 26421 34761643
Anorgasmia 15.64 10.69 20 168847 837 34787227
Hypomagnesaemia 15.64 10.69 168 168699 21683 34766381
Cardiac discomfort 15.60 10.69 17 168850 599 34787465
Angiopathy 15.58 10.69 50 168817 4123 34783941
Vascular access site occlusion 15.58 10.69 7 168860 53 34788011
Euphoric mood 15.58 10.69 4 168863 5637 34782427
Blood product transfusion dependent 15.57 10.69 14 168853 389 34787675
Spinal pain 15.54 10.69 63 168804 5826 34782238
Muscle enzyme increased 15.51 10.69 12 168855 269 34787795
Drug eruption 15.50 10.69 47 168820 19851 34768213
Pulmonary valve disease 15.44 10.69 13 168854 330 34787734
Allergy to animal 15.39 10.69 14 168853 395 34787669
Congenital heart valve disorder 15.36 10.69 7 168860 55 34788009
Feeling abnormal 15.34 10.69 214 168653 63021 34725043
Internal fixation of fracture 15.33 10.69 8 168859 87 34787977
Erysipelas 15.28 10.69 55 168812 4808 34783256
Microcytic anaemia 15.27 10.69 35 168832 2365 34785699
Intrapericardial thrombosis 15.25 10.69 7 168860 56 34788008
Haemoglobin urine present 15.21 10.69 9 168858 127 34787937
Facial bones fracture 15.21 10.69 36 168831 2484 34785580
Akinesia 15.18 10.69 33 168834 2151 34785913
Blood pressure inadequately controlled 15.17 10.69 37 168830 2603 34785461
Peripheral pulse decreased 15.13 10.69 4 168863 3 34788061
Derailment 15.13 10.69 4 168863 3 34788061
Splenic cyst 15.09 10.69 9 168858 129 34787935
Drug-disease interaction 15.09 10.69 15 168852 474 34787590
Gastrointestinal disorder 15.04 10.69 99 168768 33849 34754215
Intervertebral disc displacement 15.03 10.69 9 168858 130 34787934
Device issue 15.03 10.69 15 168852 9762 34778302
Raynaud's phenomenon 14.99 10.69 12 168855 283 34787781
Fatigue 14.99 10.69 1565 167302 369088 34418976
Progressive multifocal leukoencephalopathy 14.99 10.69 15 168852 9749 34778315
Osteomyelitis 14.93 10.69 35 168832 16101 34771963
Nausea 14.87 10.69 1427 167440 338481 34449583
Oesophageal discomfort 14.84 10.69 7 168860 60 34788004
Pseudomonas infection 14.84 10.69 23 168844 12359 34775705
Peritonitis 14.74 10.69 36 168831 16329 34771735
Incorrect route of product administration 14.72 10.69 31 168836 14814 34773250
Nephrolithiasis 14.71 10.69 86 168781 30247 34757817
Gout 14.71 10.69 150 168717 19103 34768961
Blood lactic acid increased 14.71 10.69 68 168799 6660 34781404
Helicobacter test false negative 14.55 10.69 7 168860 63 34788001
Faeces pale 14.41 10.69 25 168842 1378 34786686
Gingival hypertrophy 14.39 10.69 29 168838 1792 34786272
Underdose 14.32 10.69 28 168839 13752 34774312
Lichenoid keratosis 14.25 10.69 35 168832 2473 34785591
5-hydroxyindolacetic acid in urine increased 14.24 10.69 11 168856 246 34787818
Accessory spleen 14.24 10.69 9 168858 144 34787920
Ventricular internal diameter abnormal 14.20 10.69 10 168857 193 34787871
Osteoma 14.16 10.69 8 168859 103 34787961
BK virus infection 14.16 10.69 5 168862 5733 34782331
Tendon pain 14.14 10.69 39 168828 2956 34785108
Necrotising myositis 14.13 10.69 17 168850 668 34787396
Activated partial thromboplastin time abnormal 14.13 10.69 9 168858 146 34787918
Left ventricular hypertrophy 14.12 10.69 77 168790 8053 34780011
Oxygen consumption decreased 14.09 10.69 11 168856 250 34787814
Thyroiditis acute 14.03 10.69 8 168859 105 34787959
Mean cell haemoglobin concentration 14.00 10.69 6 168861 40 34788024
Glomerular filtration rate abnormal 13.99 10.69 19 168848 844 34787220
Cystitis haemorrhagic 13.92 10.69 5 168862 5674 34782390
Breath sounds abnormal 13.92 10.69 68 168799 6813 34781251
Intracranial haematoma 13.91 10.69 14 168853 449 34787615
Altered state of consciousness 13.91 10.69 60 168807 22833 34765231
Cerebral calcification 13.89 10.69 8 168859 107 34787957
Venous pressure jugular decreased 13.87 10.69 6 168861 41 34788023
Prostatic haemorrhage 13.87 10.69 11 168856 256 34787808
Suspected suicide 13.84 10.69 3 168864 4745 34783319
Migraine 13.82 10.69 41 168826 17437 34770627
Incorrect dose administered 13.81 10.69 127 168740 40388 34747676
Clostridium difficile infection 13.77 10.69 46 168821 18852 34769212
Atrial thrombosis 13.77 10.69 32 168835 2182 34785882
Arthropathy 13.75 10.69 75 168792 26832 34761232
Delusion 13.73 10.69 25 168842 12610 34775454
Echocardiogram abnormal 13.71 10.69 21 168846 1042 34787022
Pyelitis 13.70 10.69 8 168859 110 34787954
Neutropenia neonatal 13.60 10.69 17 168850 695 34787369
Arthritis 13.59 10.69 92 168775 31254 34756810
Neuroleptic malignant syndrome 13.52 10.69 43 168824 17891 34770173
Pulmonary congestion 13.42 10.69 113 168754 13652 34774412
Prohormone brain natriuretic peptide increased 13.42 10.69 7 168860 76 34787988
Base excess decreased 13.40 10.69 10 168857 212 34787852
Coronary artery bypass 13.38 10.69 53 168814 4849 34783215
Cardiac output decreased 13.37 10.69 19 168848 881 34787183
Splenic necrosis 13.34 10.69 8 168859 116 34787948
Discharge 13.24 10.69 12 168855 337 34787727
Dyspnoea paroxysmal nocturnal 13.22 10.69 25 168842 1474 34786590
Immunodeficiency 13.21 10.69 5 168862 5493 34782571
Hepatic cyst 13.18 10.69 35 168832 2594 34785470
Device pacing issue 13.18 10.69 6 168861 47 34788017
Large for dates baby 13.08 10.69 19 168848 899 34787165
Megakaryocytes increased 13.07 10.69 6 168861 48 34788016
Pulmonary thrombosis 13.04 10.69 10 168857 7397 34780667
Mitral valve calcification 13.03 10.69 15 168852 562 34787502
Breast hyperplasia 13.01 10.69 3 168864 0 34788064
Oliguria 12.99 10.69 77 168790 8303 34779761
Right ventricular enlargement 12.98 10.69 12 168855 346 34787718
Central nervous system mass 12.95 10.69 9 168858 170 34787894
Oropharyngeal swelling 12.95 10.69 14 168853 489 34787575
Subclavian artery occlusion 12.93 10.69 8 168859 123 34787941
Ischaemia 12.89 10.69 50 168817 4530 34783534
Pneumothorax 12.89 10.69 48 168819 19044 34769020
Fungal infection 12.88 10.69 37 168830 15898 34772166
Atrial septal defect 12.83 10.69 70 168797 7322 34780742
Wall motion score index abnormal 12.81 10.69 9 168858 173 34787891
Congenital aortic anomaly 12.74 10.69 7 168860 85 34787979
Tardive dyskinesia 12.74 10.69 6 168861 5784 34782280
Duodenal ulcer haemorrhage 12.73 10.69 53 168814 4960 34783104
Body temperature decreased 12.71 10.69 107 168760 12927 34775137
Sinoatrial block 12.68 10.69 14 168853 501 34787563
Abdominal pain lower 12.65 10.69 91 168776 10480 34777584
Depressed level of consciousness 12.64 10.69 139 168728 42702 34745362
Behaviour disorder 12.60 10.69 4 168863 4906 34783158
Colitis 12.58 10.69 119 168748 37631 34750433
Haematocrit increased 12.55 10.69 30 168837 2083 34785981
Monoparesis 12.55 10.69 32 168835 2314 34785750
Ventricular tachyarrhythmia 12.53 10.69 12 168855 362 34787702
Myelodysplastic syndrome 12.51 10.69 49 168818 19159 34768905
Arterial intramural haematoma 12.47 10.69 6 168861 54 34788010
Osteonecrosis 12.46 10.69 34 168833 14856 34773208
Gynaecomastia 12.39 10.69 88 168779 10092 34777972
Strangury 12.39 10.69 8 168859 133 34787931
Sex hormone binding globulin increased 12.39 10.69 4 168863 10 34788054
Fasciotomy 12.39 10.69 4 168863 10 34788054
Alopecia 12.38 10.69 68 168799 24287 34763777
Liver function test abnormal 12.37 10.69 215 168652 30859 34757205
Withdrawal syndrome 12.36 10.69 26 168841 12429 34775635
Pulse abnormal 12.34 10.69 22 168845 1239 34786825
Electrocardiogram QRS complex shortened 12.34 10.69 9 168858 184 34787880
Ammonia increased 12.25 10.69 3 168864 4366 34783698
Respiratory tract haemorrhage 12.23 10.69 22 168845 1248 34786816
Vitamin B12 decreased 12.19 10.69 22 168845 1251 34786813
Atrioventricular block first degree 12.17 10.69 60 168807 6032 34782032
Neonatal respiratory distress 12.16 10.69 15 168852 605 34787459
Ischaemic cardiomyopathy 12.12 10.69 62 168805 6327 34781737
Brain stem infarction 12.08 10.69 22 168845 1260 34786804
Pulmonary fibrosis 12.05 10.69 139 168728 18257 34769807
Oxygen saturation decreased 12.05 10.69 185 168682 53633 34734431
Malaise 12.01 10.69 1048 167819 184777 34603287
Mitral valve thickening 12.00 10.69 12 168855 382 34787682
Angiocardiogram 11.97 10.69 9 168858 193 34787871
Cardiac ventricular disorder 11.97 10.69 10 168857 251 34787813
Dysuria 11.96 10.69 191 168676 26961 34761103
Thirst 11.89 10.69 72 168795 7823 34780241
Faeces discoloured 11.89 10.69 117 168750 14761 34773303
Impaired self-care 11.89 10.69 22 168845 1276 34786788
Obsessive-compulsive disorder 11.88 10.69 6 168861 5558 34782506
Electrocardiogram ambulatory abnormal 11.84 10.69 5 168862 32 34788032
Iron deficiency anaemia 11.83 10.69 88 168779 10241 34777823
Respiratory syncytial virus infection 11.80 10.69 4 168863 4705 34783359
Blood cholinesterase decreased 11.79 10.69 8 168859 145 34787919
Seasonal allergy 11.76 10.69 9 168858 6666 34781398
Loss of personal independence in daily activities 11.74 10.69 103 168764 33076 34754988
N-terminal prohormone brain natriuretic peptide abnormal 11.70 10.69 9 168858 200 34787864
Blood phosphorus increased 11.69 10.69 12 168855 7709 34780355
Osteochondrosis 11.69 10.69 20 168847 1090 34786974
Lymphoma 11.67 10.69 27 168840 12480 34775584
Implant site extravasation 11.67 10.69 12 168855 395 34787669
Alanine aminotransferase increased 11.67 10.69 299 168568 80516 34707548
Autoimmune colitis 11.65 10.69 19 168848 995 34787069
Herpes zoster 11.65 10.69 108 168759 34291 34753773
Fibrinolysis increased 11.63 10.69 4 168863 13 34788051
Hypersensitivity vasculitis 11.59 10.69 39 168828 3296 34784768
Chronic obstructive pulmonary disease 11.58 10.69 314 168553 48604 34739460
Basal ganglia haemorrhage 11.53 10.69 18 168849 908 34787156
Glycosylated haemoglobin increased 11.47 10.69 94 168773 11266 34776798
Blood creatine phosphokinase MB increased 11.44 10.69 27 168840 1859 34786205
Hypokalaemia 11.42 10.69 365 168502 57849 34730215
Pancreatitis chronic 11.41 10.69 30 168837 2210 34785854
Implant site inflammation 11.41 10.69 7 168860 106 34787958
Necrotising retinitis 11.38 10.69 17 168850 825 34787239
Coronary angioplasty 11.36 10.69 12 168855 408 34787656
Hypovolaemia 11.34 10.69 80 168787 9154 34778910
Full blood count abnormal 11.30 10.69 49 168818 18619 34769445
Left ventricular failure 11.25 10.69 52 168815 5092 34782972
Lividity 11.25 10.69 8 168859 157 34787907
Blood ethanol increased 11.23 10.69 13 168854 490 34787574
Coronary artery occlusion 11.23 10.69 91 168776 10871 34777193
Overflow diarrhoea 11.23 10.69 5 168862 37 34788027
Epiglottitis 11.22 10.69 12 168855 414 34787650
Tuberculosis 11.20 10.69 15 168852 8562 34779502
Hydrothorax 11.19 10.69 13 168854 492 34787572
Pleural effusion 11.17 10.69 304 168563 81242 34706822
Intraventricular haemorrhage 11.15 10.69 40 168827 3491 34784573
Agonal rhythm 11.13 10.69 6 168861 70 34787994
Genital swelling 11.12 10.69 8 168859 160 34787904
Breast swelling 11.06 10.69 10 168857 280 34787784
Urticarial vasculitis 11.00 10.69 5 168862 39 34788025
Urostomy complication 10.95 10.69 3 168864 3 34788061
Nightmare 10.94 10.69 112 168755 14279 34773785
Pulmonary mass 10.91 10.69 29 168838 12783 34775281
Hepatic lesion 10.84 10.69 41 168826 3671 34784393
Cutaneous vasculitis 10.77 10.69 45 168822 4218 34783846
Acute stress disorder 10.74 10.69 8 168859 169 34787895
Device dislocation 10.73 10.69 59 168808 6190 34781874
Osteopenia 10.70 10.69 5 168862 4844 34783220

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 1493.79 9.61 5116 323741 514288 78901243
Hyperkalaemia 984.33 9.61 1724 327133 112674 79302857
General physical health deterioration 957.28 9.61 2897 325960 272341 79143190
Angioedema 653.88 9.61 1146 327711 74889 79340642
Completed suicide 605.53 9.61 136 328721 245631 79169900
Drug ineffective 552.25 9.61 2442 326415 1078471 78337060
Hyponatraemia 543.14 9.61 1791 327066 176057 79239474
Syncope 533.67 9.61 1791 327066 177658 79237873
Bradycardia 527.13 9.61 1486 327371 134071 79281460
Death 519.12 9.61 967 327890 565547 78849984
Product prescribing error 518.48 9.61 773 328084 44040 79371491
Drug interaction 471.06 9.61 3126 325731 412057 79003474
Hypertensive crisis 462.78 9.61 497 328360 20273 79395258
Hypotension 437.07 9.61 3209 325648 437108 78978423
Product dose omission issue 407.47 9.61 259 328598 247278 79168253
Off label use 387.59 9.61 2180 326677 905035 78510496
Cardiac failure 340.05 9.61 1402 327455 153440 79262091
Swollen tongue 297.37 9.61 587 328270 41983 79373548
Lactic acidosis 291.82 9.61 790 328067 69569 79345962
Angina pectoris 285.56 9.61 648 328209 51084 79364447
Presyncope 262.85 9.61 546 328311 40508 79375023
Product monitoring error 254.84 9.61 244 328613 8662 79406869
Atrial fibrillation 247.87 9.61 1529 327328 196357 79219174
Febrile neutropenia 238.95 9.61 364 328493 230635 79184896
Toxicity to various agents 231.43 9.61 924 327933 420616 78994915
Hypoglycaemia 226.96 9.61 925 327932 100669 79314862
Dizziness 225.19 9.61 3228 325629 523213 78892318
Myocardial infarction 214.63 9.61 1397 327460 182732 79232799
Lip swelling 208.83 9.61 497 328360 40414 79375117
Dehydration 207.63 9.61 1740 327117 246447 79169084
White blood cell count decreased 205.20 9.61 286 328571 188002 79227529
Melaena 198.99 9.61 628 328229 60262 79355269
Confusional state 197.36 9.61 2092 326765 315905 79099626
Sopor 190.57 9.61 421 328436 32589 79382942
Disease progression 189.20 9.61 292 328565 184070 79231461
Tongue oedema 177.66 9.61 181 328676 6936 79408595
Acute myocardial infarction 176.49 9.61 707 328150 76329 79339202
Orthostatic hypotension 175.11 9.61 570 328287 55594 79359937
Labelled drug-drug interaction medication error 169.16 9.61 361 328496 27289 79388242
Fall 167.65 9.61 2883 325974 484746 78930785
Haematochezia 165.79 9.61 759 328098 86886 79328645
Electrolyte imbalance 163.97 9.61 381 328476 30500 79385031
Platelet count decreased 161.71 9.61 351 328506 194313 79221218
Pain 155.51 9.61 2009 326848 701793 78713738
Neutropenia 152.50 9.61 639 328218 287071 79128460
Pneumonia 149.80 9.61 1874 326983 658372 78757159
Coronary artery disease 148.46 9.61 599 328258 64875 79350656
Circulatory collapse 147.27 9.61 414 328443 37254 79378277
Ejection fraction decreased 145.09 9.61 390 328467 34187 79381344
Rhabdomyolysis 141.91 9.61 817 328040 102314 79313217
Dyspnoea 141.74 9.61 4575 324282 852450 78563081
Arrhythmia 141.68 9.61 564 328293 60708 79354823
Pyrexia 140.60 9.61 1963 326894 676746 78738785
Hospitalisation 134.92 9.61 114 328743 94122 79321409
Injection site erythema 131.05 9.61 80 328777 78117 79337414
Liver injury 130.80 9.61 521 328336 56093 79359438
Oedema peripheral 129.51 9.61 1600 327257 250688 79164843
Systemic infection 127.02 9.61 178 328679 9574 79405957
Sinusitis 126.82 9.61 399 328458 195102 79220429
Injection site pain 124.42 9.61 215 328642 129623 79285908
Neuropathy peripheral 119.64 9.61 252 328605 141053 79274478
Medication error 114.27 9.61 573 328284 68069 79347462
Pallor 112.69 9.61 457 328400 49605 79365926
Drug ineffective for unapproved indication 109.88 9.61 37 328820 51201 79364330
Electrocardiogram abnormal 108.76 9.61 224 328633 16513 79399018
Neutrophil count decreased 107.10 9.61 138 328719 93821 79321710
Ischaemic stroke 106.66 9.61 340 328517 32791 79382740
Drug hypersensitivity 105.47 9.61 760 328097 298156 79117375
Wrong technique in product usage process 102.56 9.61 92 328765 73783 79341748
International normalised ratio increased 101.81 9.61 648 328209 84073 79331458
Loss of consciousness 101.74 9.61 1100 327757 166843 79248688
Therapeutic product effect incomplete 100.60 9.61 277 328580 141368 79274163
Product use in unapproved indication 99.11 9.61 615 328242 249744 79165787
Acute coronary syndrome 97.50 9.61 247 328610 20886 79394645
Jaundice 95.71 9.61 455 328402 52894 79362637
Cardiac failure chronic 94.56 9.61 167 328690 10968 79404563
COVID-19 93.88 9.61 334 328523 157340 79258191
Blood pressure increased 93.61 9.61 1305 327552 210055 79205476
Cerebral haemorrhage 93.58 9.61 478 328379 57195 79358336
Anaemia 92.51 9.61 2446 326411 442569 78972962
Haematemesis 89.62 9.61 440 328417 51824 79363707
Device expulsion 89.53 9.61 4 328853 25857 79389674
Cytomegalovirus infection 89.36 9.61 32 328825 42612 79372919
Hepatic function abnormal 87.92 9.61 103 328754 73004 79342527
Mitral valve incompetence 85.53 9.61 286 328571 28279 79387252
Hepatojugular reflux 84.74 9.61 45 328812 603 79414928
Haematuria 83.63 9.61 528 328329 68308 79347223
Injection site pruritus 83.20 9.61 35 328822 42248 79373283
Left ventricular dysfunction 82.86 9.61 220 328637 19141 79396390
Glomerular filtration rate decreased 82.43 9.61 243 328614 22459 79393072
Therapy interrupted 81.96 9.61 15 328842 31326 79384205
Drug abuse 79.67 9.61 372 328485 162319 79253212
Respiratory arrest 78.31 9.61 73 328784 57477 79358054
Ventricular arrhythmia 78.21 9.61 135 328722 8705 79406826
Cardio-respiratory arrest 77.94 9.61 211 328646 108299 79307232
Erectile dysfunction 77.93 9.61 181 328676 14483 79401048
Rash 77.31 9.61 1806 327051 576552 78838979
Respiratory failure 77.08 9.61 434 328423 180477 79235054
Haematoma 76.74 9.61 421 328436 51774 79363757
Hypoxia 76.25 9.61 198 328659 103045 79312486
Upper respiratory tract infection 75.98 9.61 164 328693 91004 79324527
Mental status changes 75.63 9.61 99 328758 66860 79348671
Rectal haemorrhage 75.27 9.61 556 328301 75744 79339787
Malignant neoplasm progression 75.13 9.61 297 328560 135693 79279838
Bradyarrhythmia 74.93 9.61 89 328768 4057 79411474
Renal impairment 73.84 9.61 984 327873 156799 79258732
Blood creatine phosphokinase increased 70.64 9.61 491 328366 65599 79349932
Cytokine release syndrome 70.50 9.61 30 328827 35968 79379563
Infection 70.35 9.61 647 328210 241065 79174466
Exercise tolerance decreased 69.36 9.61 130 328727 8941 79406590
Vertigo 69.06 9.61 505 328352 68577 79346954
Chest pain 68.84 9.61 1586 327271 280718 79134813
Respiratory depression 68.54 9.61 15 328842 27615 79387916
Injection site reaction 67.16 9.61 76 328781 54709 79360822
Therapeutic drug monitoring analysis not performed 67.00 9.61 59 328798 1877 79413654
Bundle branch block left 64.38 9.61 145 328712 11368 79404163
Pancreatitis acute 63.71 9.61 386 328471 49218 79366313
Abortion spontaneous 62.07 9.61 22 328835 29485 79386046
Congenital hiatus hernia 62.03 9.61 40 328817 784 79414747
Back pain 61.95 9.61 882 327975 303298 79112233
Lip oedema 61.93 9.61 101 328756 6215 79409316
Brain stem stroke 61.89 9.61 38 328819 681 79414850
Blood creatinine increased 61.36 9.61 939 327918 154118 79261413
Influenza 61.31 9.61 300 328557 129306 79286225
Therapy cessation 60.77 9.61 40 328817 37522 79378009
Arthralgia 60.03 9.61 1848 327009 569955 78845576
Type 2 diabetes mellitus 59.07 9.61 421 328436 56701 79358830
Palatal oedema 58.51 9.61 48 328809 1383 79414148
Urogenital haemorrhage 58.15 9.61 41 328816 936 79414595
Plasma cell myeloma 57.87 9.61 81 328776 53178 79362353
Stomatitis 57.77 9.61 361 328496 146396 79269135
Musculoskeletal pain 57.66 9.61 661 328196 101693 79313838
Angina unstable 57.26 9.61 174 328683 16353 79399178
Bacteraemia 57.23 9.61 32 328825 32792 79382739
Sepsis 57.08 9.61 775 328082 268653 79146878
Basilar artery thrombosis 56.83 9.61 29 328828 356 79415175
Naevus flammeus 56.36 9.61 19 328838 70 79415461
Dyspnoea at rest 56.27 9.61 105 328752 7197 79408334
Computerised tomogram coronary artery abnormal 55.73 9.61 24 328833 194 79415337
Intentional product misuse 55.69 9.61 203 328654 94962 79320569
Exposure during pregnancy 55.13 9.61 222 328635 100910 79314621
Drug dependence 55.13 9.61 52 328805 40717 79374814
Hemiparesis 55.01 9.61 280 328577 33453 79382078
Drug withdrawal syndrome 53.47 9.61 39 328818 34679 79380852
Swollen joint count increased 52.95 9.61 211 328646 22716 79392815
Cholestasis 52.69 9.61 382 328475 51727 79363804
Nasal congestion 52.64 9.61 152 328705 76400 79339131
Congestive cardiomyopathy 52.60 9.61 136 328721 11644 79403887
Coronary artery stenosis 52.55 9.61 141 328716 12343 79403188
Anuria 51.73 9.61 197 328660 20766 79394765
Drug resistance 51.27 9.61 59 328798 42154 79373377
Flushing 51.18 9.61 189 328668 88079 79327452
Fungal infection 51.08 9.61 58 328799 41690 79373841
Device issue 50.88 9.61 24 328833 27084 79388447
Renin increased 49.98 9.61 23 328834 221 79415310
Injection site swelling 49.90 9.61 73 328784 47059 79368472
Infusion related reaction 49.22 9.61 661 328196 229576 79185955
Feeling abnormal 48.99 9.61 420 328437 158779 79256752
Occult blood 48.90 9.61 47 328810 1676 79413855
Multiple sclerosis relapse 48.36 9.61 73 328784 46460 79369071
Nocturia 48.30 9.61 145 328712 13536 79401995
Bronchopulmonary aspergillosis 47.97 9.61 16 328841 22278 79393253
Atrioventricular block 47.87 9.61 147 328710 13894 79401637
Surgery 47.68 9.61 39 328818 32727 79382804
Pemphigoid 47.33 9.61 155 328702 15160 79400371
Transplant rejection 47.32 9.61 11 328846 19426 79396105
Diabetes mellitus inadequate control 47.25 9.61 212 328645 24052 79391479
Accidental exposure to product 47.19 9.61 36 328821 31286 79384245
Hyponatraemic syndrome 47.05 9.61 33 328824 747 79414784
Asthenia 46.94 9.61 2569 326288 509120 78906411
Dystonia 46.67 9.61 15 328842 21384 79394147
Sinus bradycardia 46.50 9.61 217 328640 25030 79390501
Tachyarrhythmia 46.20 9.61 94 328763 6868 79408663
Bronchitis 46.09 9.61 332 328525 130312 79285219
Palpitations 46.03 9.61 756 328101 125854 79289677
Atrioventricular block complete 45.96 9.61 162 328695 16448 79399083
Cardiovascular insufficiency 45.84 9.61 59 328798 2922 79412609
Orthopnoea 45.70 9.61 117 328740 9956 79405575
Nephritic syndrome 45.65 9.61 26 328831 403 79415128
Atrioventricular block first degree 45.63 9.61 134 328723 12357 79403174
Hyperglycaemia 45.52 9.61 467 328390 69868 79345663
Hypercholesterolaemia 45.13 9.61 202 328655 22893 79392638
Myelosuppression 45.07 9.61 60 328797 40236 79375295
Neurotoxicity 44.53 9.61 41 328816 32477 79383054
Degenerative mitral valve disease 44.40 9.61 23 328834 292 79415239
Sedation complication 44.36 9.61 6 328851 15663 79399868
Inferior vena cava dilatation 43.78 9.61 33 328824 838 79414693
Device difficult to use 43.47 9.61 3 328854 13382 79402149
Ventricular hypokinesia 43.37 9.61 109 328748 9170 79406361
Bone marrow failure 43.35 9.61 91 328766 51016 79364515
Facet joint syndrome 42.98 9.61 123 328734 11179 79404352
Orthostatic intolerance 42.78 9.61 46 328811 1878 79413653
Cerebrovascular accident 42.76 9.61 888 327969 154404 79261127
Pulmonary fibrosis 42.68 9.61 320 328537 43792 79371739
Rheumatic fever 42.54 9.61 231 328626 28294 79387237
Diabetic metabolic decompensation 42.18 9.61 60 328797 3272 79412259
Blood creatine increased 42.05 9.61 109 328748 9346 79406185
No adverse event 41.99 9.61 55 328802 37137 79378394
Graft versus host disease 41.96 9.61 6 328851 15020 79400511
Chills 41.93 9.61 440 328417 159794 79255737
Systolic dysfunction 41.79 9.61 64 328793 3731 79411800
Pancreatitis necrotising 41.77 9.61 65 328792 3843 79411688
Therapeutic response unexpected 41.74 9.61 15 328842 19931 79395600
Dysarthria 41.41 9.61 444 328413 67178 79348353
Prescribed overdose 41.39 9.61 283 328574 37600 79377931
Cerebral haematoma 41.08 9.61 97 328760 7845 79407686
Headache 40.53 9.61 2244 326613 651528 78764003
Peripheral venous disease 40.49 9.61 151 328706 15758 79399773
Tricuspid valve incompetence 40.49 9.61 175 328682 19537 79395994
Fatigue 40.41 9.61 3294 325563 926433 78489098
Herpes zoster 40.33 9.61 222 328635 92861 79322670
Renal failure 40.03 9.61 1099 327758 199869 79215662
Seizure 40.03 9.61 543 328314 188291 79227240
Disorientation 39.29 9.61 414 328443 62362 79353169
Nasopharyngitis 39.27 9.61 774 328083 253107 79162424
Swelling face 39.25 9.61 458 328399 70754 79344777
Mucosal dryness 39.16 9.61 60 328797 3499 79412032
Benign prostatic hyperplasia 39.06 9.61 121 328736 11491 79404040
Hypersensitivity myocarditis 39.02 9.61 20 328837 248 79415283
Migraine 38.83 9.61 207 328650 87286 79328245
Acute respiratory distress syndrome 38.62 9.61 77 328780 43990 79371541
Cytomegalovirus viraemia 38.55 9.61 4 328853 12817 79402714
Therapeutic product effect decreased 38.14 9.61 462 328395 163401 79252130
Hypersomnia 38.14 9.61 24 328833 23062 79392469
Sciatica 37.99 9.61 251 328606 32971 79382560
Encephalopathy 37.97 9.61 146 328711 67251 79348280
Carotid artery stenosis 37.96 9.61 100 328757 8658 79406873
Unevaluable event 37.75 9.61 111 328746 55474 79360057
Eosinophilic bronchitis 37.32 9.61 24 328833 468 79415063
Duodenal ulcer 37.28 9.61 150 328707 16219 79399312
Metabolic acidosis 37.07 9.61 511 328346 82018 79333513
Deep vein thrombosis postoperative 37.06 9.61 113 328744 10639 79404892
Dyspnoea exertional 37.05 9.61 534 328323 86539 79328992
Change of bowel habit 36.92 9.61 51 328806 2706 79412825
Potentiating drug interaction 36.52 9.61 99 328758 8720 79406811
Electrocardiogram Q wave abnormal 36.49 9.61 26 328831 604 79414927
Gastritis erosive 36.46 9.61 113 328744 10734 79404797
Gamma-glutamyltransferase increased 36.31 9.61 365 328492 54315 79361216
Illness 36.04 9.61 87 328770 46424 79369107
Psoriatic arthropathy 35.87 9.61 485 328372 77514 79338017
Arteriosclerosis coronary artery 35.70 9.61 157 328700 17659 79397872
Multiple sclerosis 35.68 9.61 24 328833 22258 79393273
Haemodialysis complication 35.57 9.61 20 328837 302 79415229
Epstein-Barr virus infection 35.41 9.61 8 328849 14408 79401123
Urosepsis 35.19 9.61 208 328649 26287 79389244
Gastrointestinal disorder 35.14 9.61 328 328529 121877 79293654
Injection site rash 35.10 9.61 15 328842 17939 79397592
Hypomagnesaemia 35.03 9.61 321 328536 46590 79368941
Maternal exposure during pregnancy 34.89 9.61 377 328480 136161 79279370
Oral herpes 34.85 9.61 37 328820 27417 79388114
Transient ischaemic attack 34.63 9.61 351 328506 52344 79363187
Obstructive pancreatitis 34.62 9.61 29 328828 861 79414670
Laryngeal oedema 34.41 9.61 92 328765 8037 79407494
Sedation 34.26 9.61 105 328752 51790 79363741
Arterial occlusive disease 34.09 9.61 94 328763 8362 79407169
Constipation 33.88 9.61 898 327959 282152 79133379
Haematotoxicity 33.63 9.61 11 328846 15508 79400023
Gingival hypertrophy 33.22 9.61 52 328805 3090 79412441
Anxiety 33.10 9.61 776 328081 247736 79167795
Asphyxia 33.03 9.61 115 328742 11605 79403926
Cellulitis 32.98 9.61 289 328568 108771 79306760
Disseminated intravascular coagulation 32.83 9.61 61 328796 35781 79379750
Pneumocystis jirovecii pneumonia 32.82 9.61 52 328805 32456 79383075
Liver function test abnormal 32.62 9.61 408 328449 64067 79351464
Labile hypertension 32.59 9.61 23 328834 526 79415005
Mydriasis 32.53 9.61 16 328841 17627 79397904
Ventricular tachycardia 32.36 9.61 289 328568 41646 79373885
Erysipelas 31.92 9.61 108 328749 10742 79404789
Rhinorrhoea 31.57 9.61 184 328673 75890 79339641
Cardiac aneurysm 31.50 9.61 35 328822 1483 79414048
Pain in jaw 31.46 9.61 92 328765 46059 79369472
Clostridium difficile infection 31.40 9.61 82 328775 42603 79372928
Lip dry 30.99 9.61 136 328721 15282 79400249
Full blood count decreased 30.96 9.61 39 328818 26780 79388751
Inappropriate antidiuretic hormone secretion 30.82 9.61 200 328657 26113 79389418
Premature delivery 30.49 9.61 31 328826 23436 79392095
Tenosynovitis 30.40 9.61 13 328844 15541 79399990
Therapy partial responder 30.27 9.61 17 328840 17380 79398151
Hemiplegia 30.20 9.61 132 328725 14807 79400724
Pulmonary vascular disorder 30.18 9.61 29 328828 1034 79414497
Fracture 30.15 9.61 173 328684 21628 79393903
Injection site bruising 29.98 9.61 79 328778 40923 79374608
Septic shock 29.82 9.61 343 328514 122458 79293073
Rhinitis allergic 29.75 9.61 7 328850 12262 79403269
Pulmonary mass 29.74 9.61 46 328811 28988 79386543
Neoplasm progression 29.73 9.61 111 328746 51571 79363960
Pathogen resistance 29.65 9.61 11 328846 14331 79401200
Cold sweat 29.64 9.61 154 328703 18545 79396986
Abdominal discomfort 29.59 9.61 797 328060 249930 79165601
Carotid arteriosclerosis 29.54 9.61 45 328812 2611 79412920
Euglycaemic diabetic ketoacidosis 29.52 9.61 78 328779 6766 79408765
Epiglottic oedema 29.44 9.61 18 328839 320 79415211
Pneumonia bacterial 29.40 9.61 22 328835 19309 79396222
Low density lipoprotein abnormal 29.05 9.61 20 328837 439 79415092
Mucosal haemorrhage 29.03 9.61 44 328813 2542 79412989
Hypoglycaemic coma 28.94 9.61 62 328795 4698 79410833
Breast cancer female 28.88 9.61 6 328851 11455 79404076
Full blood count abnormal 28.83 9.61 79 328778 40395 79375136
Urinary tract infection 28.77 9.61 887 327970 273625 79141906
Dysuria 28.66 9.61 329 328528 50622 79364909
Drug intolerance 28.52 9.61 850 328007 263269 79152262
Alopecia 28.47 9.61 731 328126 230624 79184907
Eye irritation 28.41 9.61 26 328831 20655 79394876
Hypogammaglobulinaemia 28.39 9.61 9 328848 12942 79402589
Infusion site erythema 28.32 9.61 3 328854 9457 79406074
Pharyngitis streptococcal 28.29 9.61 5 328852 10709 79404822
Haemophagocytic lymphohistiocytosis 28.20 9.61 29 328828 21808 79393723
Abdominal pain upper 28.20 9.61 1160 327697 222659 79192872
Product storage error 28.03 9.61 16 328841 16210 79399321
Immune reconstitution inflammatory syndrome 27.97 9.61 11 328846 13830 79401701
Analgesic drug level above therapeutic 27.90 9.61 20 328837 469 79415062
Pharyngeal oedema 27.89 9.61 137 328720 16135 79399396
N-terminal prohormone brain natriuretic peptide increased 27.84 9.61 61 328796 4694 79410837
Aspartate aminotransferase increased 27.84 9.61 403 328454 138238 79277293
Hypoalbuminaemia 27.82 9.61 28 328829 21269 79394262
Sleep disorder due to a general medical condition 27.79 9.61 12 328845 14265 79401266
Oxygen saturation decreased 27.73 9.61 370 328487 128677 79286854
Gravitational oedema 27.66 9.61 36 328821 1803 79413728
Appendicitis 27.56 9.61 27 328830 20767 79394764
Cytopenia 27.55 9.61 26 328831 20357 79395174
Fluid intake reduced 27.46 9.61 72 328785 6216 79409315
Cerebral ischaemia 27.45 9.61 105 328752 11090 79404441
Thrombocytopenia 27.33 9.61 859 327998 264400 79151131
Seasonal allergy 27.18 9.61 17 328840 16389 79399142
Actinic elastosis 27.08 9.61 10 328847 51 79415480
Gangrene 27.05 9.61 90 328767 8874 79406657
Abnormal loss of weight 26.99 9.61 86 328771 8290 79407241
Neuroleptic malignant syndrome 26.97 9.61 45 328812 27514 79388017
Pancytopenia 26.93 9.61 501 328356 165244 79250287
Heavy menstrual bleeding 26.92 9.61 12 328845 13999 79401532
Poisoning 26.89 9.61 39 328818 25233 79390298
Fluid retention 26.80 9.61 173 328684 69636 79345895
Diabetic ketoacidosis 26.76 9.61 236 328621 33886 79381645
Device leakage 26.71 9.61 6 328851 10850 79404681
Blood potassium increased 26.44 9.61 209 328648 29066 79386465
Neck pain 26.43 9.61 192 328665 75225 79340306
Ventricular dysfunction 26.34 9.61 69 328788 5954 79409577
Inappropriate schedule of product administration 26.28 9.61 390 328467 133238 79282293
Injection site urticaria 26.24 9.61 10 328847 12816 79402715
Antidepressant drug level above therapeutic 26.24 9.61 22 328835 654 79414877
Mouth swelling 26.14 9.61 69 328788 5982 79409549
Dermatitis exfoliative 26.09 9.61 101 328756 10728 79404803
Hypovolaemic shock 25.99 9.61 110 328747 12166 79403365
Hypersensitivity 25.88 9.61 854 328003 261385 79154146
Duodenitis 25.86 9.61 82 328775 7885 79407646
Left ventricular hypertrophy 25.85 9.61 103 328754 11088 79404443
Gynaecomastia 25.80 9.61 80 328777 7601 79407930
Treatment failure 25.67 9.61 522 328335 169964 79245567
Ketoacidosis 25.64 9.61 81 328776 7773 79407758
Adrenal insufficiency 25.64 9.61 49 328808 28438 79387093
Incorrect dose administered 25.47 9.61 198 328659 76432 79339099
Infective exacerbation of chronic obstructive airways disease 25.27 9.61 43 328814 2741 79412790
Prescribed underdose 25.19 9.61 208 328649 29306 79386225
Helicobacter gastritis 25.16 9.61 40 328817 2409 79413122
Acne 25.15 9.61 46 328811 27144 79388387
Autoimmune disorder 25.09 9.61 135 328722 16477 79399054
Skin weeping 25.00 9.61 26 328831 1021 79414510
Electrocardiogram QT prolonged 24.91 9.61 517 328340 89869 79325662
Vaginal haemorrhage 24.90 9.61 32 328825 21785 79393746
Blood pressure systolic decreased 24.83 9.61 101 328756 10975 79404556
Hospice care 24.82 9.61 6 328851 10318 79405213
Ocular myasthenia 24.81 9.61 17 328840 370 79415161
Oropharyngeal swelling 24.60 9.61 29 328828 1311 79414220
Myalgia 24.50 9.61 967 327890 184674 79230857
Product use issue 24.49 9.61 668 328189 209154 79206377
Anal haemorrhage 24.43 9.61 54 328803 4180 79411351
Venoocclusive liver disease 24.38 9.61 9 328848 11762 79403769
Vomiting 24.37 9.61 3118 325739 662710 78752821
Urinary hesitation 24.16 9.61 54 328803 4212 79411319
Aspergillus infection 24.12 9.61 26 328831 19135 79396396
Liver disorder 24.12 9.61 187 328670 72230 79343301
Polyp 24.12 9.61 81 328776 8026 79407505
Thrombosis 24.05 9.61 226 328631 83874 79331657
Thirst 23.97 9.61 145 328712 18474 79397057
Rectal polyp 23.94 9.61 32 328825 1645 79413886
Dry skin 23.87 9.61 173 328684 67822 79347709
Brain stem infarction 23.83 9.61 35 328822 1966 79413565
Lymphocyte count decreased 23.80 9.61 107 328750 47182 79368349
Mouth breathing 23.76 9.61 12 328845 144 79415387
Malnutrition 23.67 9.61 35 328822 22467 79393064
Nephrotic syndrome 23.56 9.61 100 328757 11074 79404457
Malignant spinal cord compression 23.54 9.61 12 328845 147 79415384
Intestinal haemorrhage 23.53 9.61 69 328788 6357 79409174
Osteomyelitis 23.52 9.61 64 328793 32801 79382730
Glomerular filtration rate 23.47 9.61 12 328845 148 79415383
Intraventricular haemorrhage 23.47 9.61 58 328799 4829 79410702
Hypokalaemia 23.35 9.61 768 328089 143272 79272259
Insomnia 23.35 9.61 802 328055 244368 79171163
Granulocytopenia 23.24 9.61 9 328848 11422 79404109
Tachypnoea 23.24 9.61 218 328639 31845 79383686
Staphylococcal infection 23.13 9.61 143 328714 58152 79357379
Paresis 23.09 9.61 53 328804 4208 79411323
Nodule 23.01 9.61 37 328820 22957 79392574
Heart rate decreased 22.70 9.61 412 328445 69904 79345627
Temperature intolerance 22.64 9.61 6 328851 9699 79405832
Hyperthyroidism 22.56 9.61 163 328694 22046 79393485
Sleep disorder due to general medical condition, insomnia type 22.25 9.61 98 328759 43458 79372073
Epistaxis 22.24 9.61 610 328247 110905 79304626
Mitral valve disease 22.21 9.61 44 328813 3153 79412378
Adenovirus infection 22.18 9.61 4 328853 8443 79407088
Infusion site swelling 22.15 9.61 3 328854 7823 79407708
Hypersensitivity vasculitis 22.11 9.61 71 328786 6872 79408659
Gastroenteritis clostridial 22.08 9.61 23 328834 905 79414626
Candida infection 22.03 9.61 82 328775 38132 79377399
Cerebral artery thrombosis 22.00 9.61 25 328832 1086 79414445
Irritability 21.99 9.61 91 328766 41053 79374478
Ill-defined disorder 21.99 9.61 170 328687 65705 79349826
Pneumothorax 21.93 9.61 53 328804 28270 79387261
Blood pressure systolic increased 21.81 9.61 393 328464 66593 79348938
Unintentional medical device removal 21.72 9.61 3 328854 7709 79407822
Cardiogenic shock 21.53 9.61 266 328591 41648 79373883
Nicotine dependence 21.53 9.61 23 328834 932 79414599
Acute graft versus host disease in skin 21.52 9.61 3 328854 7655 79407876
Myopathy 21.51 9.61 152 328705 20411 79395120
Stenosis 21.44 9.61 37 328820 2385 79413146
Myositis 21.42 9.61 144 328713 19024 79396507
Helicobacter test positive 21.39 9.61 27 328830 1311 79414220
Hypercreatininaemia 21.37 9.61 24 328833 1029 79414502
Embolic stroke 21.37 9.61 76 328781 7750 79407781
Normocytic anaemia 21.34 9.61 51 328806 4156 79411375
Posterior reversible encephalopathy syndrome 21.29 9.61 48 328809 26233 79389298
Pulmonary arterial hypertension 21.24 9.61 54 328803 28312 79387219
Tongue disorder 21.13 9.61 16 328841 13959 79401572
Deep vein thrombosis 21.07 9.61 361 328496 120558 79294973
Pulmonary thrombosis 21.02 9.61 12 328845 12159 79403372
Arteriosclerosis 21.01 9.61 138 328719 18089 79397442
Hypertrophy 20.95 9.61 21 328836 789 79414742
Lymphadenopathy 20.93 9.61 131 328726 53116 79362415
Restlessness 20.92 9.61 288 328569 46204 79369327
Ventricular enlargement 20.84 9.61 20 328837 712 79414819
Physical examination abnormal 20.83 9.61 14 328843 295 79415236
Synovitis 20.81 9.61 468 328389 150266 79265265
Foetal death 20.71 9.61 4 328853 8040 79407491
Pelvic pain 20.65 9.61 15 328842 13366 79402165
Abdominal pain lower 20.55 9.61 211 328646 31571 79383960
Neoplasm malignant 20.55 9.61 65 328792 31745 79383786
Hyperammonaemia 20.54 9.61 10 328847 11083 79404448
Appendicolith 20.50 9.61 5 328852 8546 79406985
Hypercreatinaemia 20.46 9.61 14 328843 304 79415227
Muscular weakness 20.46 9.61 834 328023 159895 79255636
Troponin I increased 20.44 9.61 54 328803 4684 79410847
Weight increased 20.42 9.61 935 327922 276451 79139080
Anaemia macrocytic 20.40 9.61 60 328797 5537 79409994
Acute pulmonary oedema 20.39 9.61 114 328743 14116 79401415
Carcinogenicity 20.36 9.61 9 328848 78 79415453
Femur fracture 20.34 9.61 86 328771 38566 79376965
Cushingoid 20.30 9.61 7 328850 9545 79405986
Lordosis 20.29 9.61 16 328841 435 79415096
Pancreatic neuroendocrine tumour 20.28 9.61 19 328838 656 79414875
Pharyngeal swelling 20.26 9.61 74 328783 7645 79407886
Upper motor neurone lesion 20.24 9.61 13 328844 253 79415278
Pulmonary alveolar haemorrhage 20.22 9.61 11 328846 11446 79404085
Dry eye 20.16 9.61 81 328776 36850 79378681
Coma scale abnormal 20.15 9.61 80 328777 8598 79406933
Band neutrophil percentage decreased 20.11 9.61 6 328851 13 79415518
Brain scan abnormal 20.06 9.61 25 328832 1198 79414333
Post-traumatic amnestic disorder 20.06 9.61 8 328849 52 79415479
Oedema mouth 20.02 9.61 41 328816 3010 79412521
Interstitial lung disease 20.00 9.61 335 328522 112265 79303266
Jealous delusion 19.99 9.61 14 328843 316 79415215
Tumour lysis syndrome 19.99 9.61 43 328814 23896 79391635
Lethargy 19.86 9.61 457 328400 80835 79334696
Xyphoid retraction 19.81 9.61 11 328846 162 79415369
Listless 19.80 9.61 47 328810 3814 79411717
Cardiac septal hypertrophy 19.71 9.61 13 328844 265 79415266
Depressed mood 19.70 9.61 295 328562 48185 79367346
Adjustment disorder with depressed mood 19.69 9.61 82 328775 9004 79406527
Renal artery stenosis 19.63 9.61 44 328813 3438 79412093
Basal ganglia haemorrhage 19.57 9.61 29 328828 1642 79413889
BK virus infection 19.51 9.61 6 328851 8798 79406733
Device use error 19.45 9.61 3 328854 7098 79408433
Withdrawal syndrome 19.44 9.61 52 328805 26802 79388729
Melanoderma 19.43 9.61 15 328842 395 79415136
Blood cholesterol increased 19.33 9.61 467 328390 83253 79332278
Nephroangiosclerosis 19.29 9.61 14 328843 335 79415196
Infusion site pain 19.26 9.61 18 328839 14158 79401373
Ammonia increased 19.23 9.61 4 328853 7631 79407900
Hypovolaemia 19.23 9.61 132 328725 17559 79397972
Injection site discolouration 19.16 9.61 4 328853 7610 79407921
Cystitis haemorrhagic 19.02 9.61 7 328850 9165 79406366
Cough 19.00 9.61 1758 327099 365031 79050500
Gastritis haemorrhagic 18.98 9.61 37 328820 2620 79412911
Middle insomnia 18.93 9.61 23 328834 16046 79399485
Eosinophilia 18.85 9.61 277 328580 45068 79370463
Anastomotic infection 18.83 9.61 10 328847 134 79415397
Tachycardia 18.79 9.61 905 327952 176863 79238668
Bundle branch block right 18.77 9.61 94 328763 11157 79404374
Myocardial ischaemia 18.74 9.61 174 328683 25345 79390186
ECG signs of myocardial ischaemia 18.69 9.61 14 328843 352 79415179
Left ventricular enlargement 18.67 9.61 19 328838 727 79414804
Failure to thrive 18.64 9.61 13 328844 11831 79403700
Pulmonary valve disease 18.51 9.61 13 328844 295 79415236
Hypertensive angiopathy 18.50 9.61 9 328848 99 79415432
Arterial stenosis 18.39 9.61 26 328831 1410 79414121
Dermatitis allergic 18.38 9.61 133 328724 17997 79397534
Oesophagitis haemorrhagic 18.36 9.61 18 328839 658 79414873
Red blood cell abnormality 18.33 9.61 19 328838 743 79414788
Lichenoid keratosis 18.28 9.61 47 328810 4010 79411521
Needle issue 18.27 9.61 104 328753 12964 79402567
Type V hyperlipidaemia 18.21 9.61 22 328835 1021 79414510
Sputum discoloured 18.20 9.61 39 328818 21704 79393827
Low cardiac output syndrome 18.18 9.61 22 328835 1023 79414508
Polyuria 18.12 9.61 115 328742 14899 79400632
Hepatitis acute 18.12 9.61 118 328739 15424 79400107
Throat irritation 18.09 9.61 97 328760 40849 79374682
Bone density decreased 18.07 9.61 17 328840 13330 79402201
Pulmonary toxicity 18.02 9.61 16 328841 12898 79402633
Respiratory tract inflammation 17.99 9.61 20 328837 848 79414683
Breast cancer stage I 17.97 9.61 3 328854 6697 79408834
Patent ductus arteriosus 17.96 9.61 9 328848 106 79415425
Hypochloraemia 17.94 9.61 35 328822 2480 79413051
Ischaemic cardiomyopathy 17.91 9.61 71 328786 7624 79407907
Osteoma 17.89 9.61 9 328848 107 79415424
Intentional dose omission 17.83 9.61 7 328850 8810 79406721
Akathisia 17.82 9.61 17 328840 13242 79402289
Psychogenic tremor 17.82 9.61 6 328851 22 79415509
Product dose omission in error 17.82 9.61 5 328852 7783 79407748
Device breakage 17.77 9.61 11 328846 10664 79404867
Megakaryocytes increased 17.74 9.61 9 328848 109 79415422
Arteriosclerotic gangrene 17.74 9.61 8 328849 73 79415458
Genitourinary symptom 17.68 9.61 12 328845 257 79415274
Coronary arterial stent insertion 17.64 9.61 60 328797 5984 79409547
Skin turgor decreased 17.60 9.61 19 328838 779 79414752
Musculoskeletal disorder 17.52 9.61 39 328818 21409 79394122
Faecaloma 17.48 9.61 94 328763 11470 79404061
Wound 17.45 9.61 614 328243 115565 79299966
Lupus vulgaris 17.45 9.61 41 328816 3305 79412226
Post procedural haematoma 17.44 9.61 34 328823 2408 79413123
Gastroenteritis viral 17.29 9.61 49 328808 24782 79390749
Ventricular tachyarrhythmia 17.29 9.61 14 328843 396 79415135
Breast cancer 17.26 9.61 76 328781 33705 79381826
Faeces discoloured 17.25 9.61 190 328667 28937 79386594
Macrophages increased 17.21 9.61 12 328845 269 79415262
Metastases to bone 17.16 9.61 48 328809 24379 79391152
Atrial thrombosis 17.14 9.61 43 328814 3613 79411918
Bradyphrenia 17.12 9.61 88 328769 10552 79404979
Diastolic dysfunction 17.11 9.61 89 328768 10722 79404809
Irregular sleep wake rhythm disorder 17.02 9.61 13 328844 337 79415194
Hypomania 16.97 9.61 5 328852 7539 79407992
Pneumatosis intestinalis 16.86 9.61 3 328854 6394 79409137
Left atrial dilatation 16.84 9.61 39 328818 3114 79412417
Chronic kidney disease 16.82 9.61 374 328483 65780 79349751
Delusion 16.79 9.61 37 328820 20386 79395145
Muscle enzyme increased 16.73 9.61 14 328843 415 79415116
Abnormal weight gain 16.72 9.61 35 328822 2609 79412922
Eczema nummular 16.66 9.61 13 328844 348 79415183
Dilatation ventricular 16.64 9.61 46 328811 4098 79411433
Pericardial disease 16.64 9.61 16 328841 571 79414960
Blood sodium decreased 16.63 9.61 210 328647 33045 79382486
Back disorder 16.57 9.61 14 328843 11564 79403967
Pregnancy 16.56 9.61 56 328801 26795 79388736
Colitis 16.55 9.61 208 328649 73099 79342432
Blood bilirubin abnormal 16.55 9.61 25 328832 1440 79414091
Tooth dislocation 16.51 9.61 6 328851 29 79415502
Blood pressure diastolic decreased 16.50 9.61 194 328663 30022 79385509
Procedural pain 16.48 9.61 45 328812 23039 79392492
Drop attacks 16.41 9.61 21 328836 1034 79414497
X-ray abnormal 16.35 9.61 57 328800 5756 79409775
Mitral valve hypoplasia 16.34 9.61 6 328851 30 79415501
Shone complex 16.34 9.61 6 328851 30 79415501
Drug dose omission by device 16.32 9.61 3 328854 6247 79409284
Intrapericardial thrombosis 16.32 9.61 7 328850 56 79415475
Laboratory test abnormal 16.29 9.61 60 328797 27988 79387543
Hypervolaemia 16.28 9.61 106 328751 42584 79372947
Sudden cardiac death 16.25 9.61 53 328804 5172 79410359
Swelling 16.25 9.61 729 328128 215982 79199549
Angiopathy 16.21 9.61 65 328792 7017 79408514
Congenital aortic valve stenosis 16.18 9.61 6 328851 31 79415500
Cardiac output decreased 16.17 9.61 28 328829 1810 79413721
Burning sensation 16.15 9.61 159 328698 58473 79357058
Hiatus hernia 16.15 9.61 157 328700 23155 79392376
Mucosal inflammation 16.12 9.61 217 328640 75363 79340168
Granuloma 16.11 9.61 7 328850 8290 79407241
Abnormal clotting factor 16.11 9.61 10 328847 183 79415348
Loss of proprioception 16.10 9.61 18 328839 768 79414763
Aorta hypoplasia 16.03 9.61 6 328851 32 79415499
Perineal pain 15.99 9.61 21 328836 1061 79414470
Aplastic anaemia 15.94 9.61 31 328826 17874 79397657
Wheelchair user 15.89 9.61 3 328854 6129 79409402
Hepatic encephalopathy 15.88 9.61 49 328808 24117 79391414
Complication associated with device 15.83 9.61 30 328827 17466 79398065
Drug tolerance 15.79 9.61 8 328849 8667 79406864
Lymphoma 15.74 9.61 30 328827 17430 79398101
Amenorrhoea 15.73 9.61 6 328851 7686 79407845
Thyroiditis acute 15.73 9.61 10 328847 191 79415340
5-hydroxyindolacetic acid in urine increased 15.72 9.61 11 328846 248 79415283
Burns second degree 15.71 9.61 34 328823 2594 79412937
Transfusion 15.67 9.61 41 328816 21289 79394242
Atelectasis 15.63 9.61 74 328783 32183 79383348
Helicobacter test false negative 15.61 9.61 7 328850 63 79415468
Metastases to lymph nodes 15.60 9.61 12 328845 10385 79405146
Disease recurrence 15.59 9.61 112 328745 43997 79371534
Idiopathic angioedema 15.51 9.61 7 328850 64 79415467
Subdural haematoma 15.51 9.61 198 328659 31236 79384295
Pneumonia aspiration 15.50 9.61 189 328668 66778 79348753
Hypertensive emergency 15.49 9.61 35 328822 2750 79412781
Gastrooesophageal reflux disease 15.44 9.61 320 328537 103926 79311605
Red blood cell count decreased 15.42 9.61 157 328700 57356 79358175
Ascites 15.39 9.61 219 328638 75343 79340188
Normal newborn 15.35 9.61 5 328852 7067 79408464
Suspiciousness 15.33 9.61 16 328841 631 79414900
Ischaemia 15.31 9.61 70 328787 8005 79407526
Osteonecrosis 15.27 9.61 71 328786 31024 79384507
Colitis erosive 15.23 9.61 9 328848 150 79415381
Faeces pale 15.22 9.61 36 328821 2914 79412617
Malaise 15.18 9.61 2272 326585 487597 78927934
Camptocormia 15.17 9.61 14 328843 474 79415057
Electrocardiogram ambulatory abnormal 15.04 9.61 6 328851 39 79415492
Hot flush 15.04 9.61 149 328708 54728 79360803
Product administration error 15.04 9.61 199 328658 31647 79383884
Respiratory tract haemorrhage 15.04 9.61 27 328830 1796 79413735
Blood glucose fluctuation 15.03 9.61 61 328796 6621 79408910
Fear of injection 15.00 9.61 6 328851 7468 79408063
Malignant melanoma in situ 14.98 9.61 32 328825 2420 79413111
Ear infection 14.98 9.61 82 328775 34350 79381181
Arterial spasm 14.97 9.61 9 328848 155 79415376
Alanine aminotransferase abnormal 14.95 9.61 9 328848 8858 79406673
Palmar-plantar erythrodysaesthesia syndrome 14.92 9.61 78 328779 33056 79382475
Congenital heart valve disorder 14.91 9.61 6 328851 40 79415491
Metastases to liver 14.90 9.61 63 328794 28251 79387280
Spinal operation 14.87 9.61 7 328850 7910 79407621
Cerebral artery occlusion 14.85 9.61 26 328831 1696 79413835
Hallucination, visual 14.83 9.61 203 328654 32526 79383005
Apathy 14.81 9.61 98 328759 12879 79402652
Sinus node dysfunction 14.78 9.61 67 328790 7634 79407897
Obesity 14.77 9.61 215 328642 34910 79380621
Brain compression 14.76 9.61 15 328842 573 79414958
Cardioactive drug level increased 14.72 9.61 41 328816 3668 79411863
Psychotic disorder 14.70 9.61 105 328752 41297 79374234
Hepatotoxicity 14.68 9.61 138 328719 51214 79364317
Mean cell haemoglobin concentration 14.67 9.61 6 328851 42 79415489
Hip fracture 14.65 9.61 71 328786 30690 79384841
Hepatorenal failure 14.62 9.61 22 328835 1263 79414268
Colitis microscopic 14.60 9.61 85 328772 10683 79404848
Cardiac discomfort 14.58 9.61 22 328835 1266 79414265
Upper-airway cough syndrome 14.57 9.61 16 328841 11677 79403854
Gingival swelling 14.56 9.61 47 328810 4562 79410969
Polycystic liver disease 14.53 9.61 9 328848 164 79415367
Pneumonia viral 14.48 9.61 10 328847 9148 79406383
Hepatic lesion 14.46 9.61 62 328795 6897 79408634
Gout 14.46 9.61 161 328696 24588 79390943
Toxic neuropathy 14.45 9.61 19 328838 961 79414570
Foot operation 14.45 9.61 3 328854 5730 79409801
Heart rate increased 14.42 9.61 383 328474 120341 79295190
Hysterectomy 14.40 9.61 4 328853 6268 79409263
Prostatic haemorrhage 14.39 9.61 9 328848 167 79415364
Nocardiosis 14.26 9.61 3 328854 5676 79409855
Fracture blisters 14.23 9.61 7 328850 79 79415452
Vascular access site occlusion 14.23 9.61 7 328850 79 79415452
Toothache 14.21 9.61 39 328818 19931 79395600
Tooth injury 14.20 9.61 28 328829 2000 79413531
Frontotemporal dementia 14.20 9.61 15 328842 600 79414931
Coronary artery bypass 14.17 9.61 56 328801 6006 79409525
Cholecystitis chronic 14.15 9.61 12 328845 9894 79405637
Product quality issue 14.13 9.61 82 328775 33858 79381673
Wall motion score index abnormal 14.11 9.61 9 328848 173 79415358
Stupor 14.11 9.61 61 328796 6811 79408720
Aortic valve incompetence 14.09 9.61 77 328780 9453 79406078
Lividity 14.09 9.61 13 328844 440 79415091
Ocular hyperaemia 14.09 9.61 64 328793 28142 79387389
Central nervous system mass 14.06 9.61 9 328848 174 79415357
Body height decreased 14.06 9.61 9 328848 8571 79406960
Hydronephrosis 14.04 9.61 32 328825 17422 79398109
Diabetes mellitus 14.02 9.61 423 328434 77967 79337564
Eye pain 13.98 9.61 94 328763 37484 79378047
Nausea 13.96 9.61 3622 325235 953574 78461957
Gastrointestinal haemorrhage 13.95 9.61 744 328113 146975 79268556
Gastrointestinal perforation 13.93 9.61 4 328853 6133 79409398
Chromaturia 13.92 9.61 165 328692 25581 79389950
Pre-existing condition improved 13.84 9.61 3 328854 5560 79409971
Prerenal failure 13.82 9.61 40 328817 3658 79411873
Acute abdomen 13.78 9.61 36 328821 3101 79412430
Demyelination 13.73 9.61 8 328849 8015 79407516
Tardive dyskinesia 13.69 9.61 14 328843 10557 79404974
Mesenteric arterial occlusion 13.65 9.61 10 328847 243 79415288
Coeliac disease 13.64 9.61 16 328841 11335 79404196
Congenital aortic stenosis 13.62 9.61 5 328852 25 79415506
Congenital aortic anomaly 13.62 9.61 5 328852 25 79415506
Supravalvular aortic stenosis 13.62 9.61 5 328852 25 79415506
Sex hormone binding globulin increased 13.62 9.61 4 328853 8 79415523
Coronary artery dissection 13.61 9.61 20 328837 1124 79414407
Cerebellar stroke 13.56 9.61 14 328843 545 79414986
Protein urine present 13.55 9.61 13 328844 10099 79405432
Strangury 13.54 9.61 9 328848 186 79415345
Akinesia 13.53 9.61 37 328820 3275 79412256
Petechiae 13.52 9.61 137 328720 20428 79395103
Duodenal ulcer haemorrhage 13.51 9.61 62 328795 7101 79408430
Shock hypoglycaemic 13.51 9.61 10 328847 247 79415284
Joint swelling 13.49 9.61 1016 327841 287630 79127901
Uraemic gastropathy 13.49 9.61 3 328854 0 79415531
Premature labour 13.48 9.61 9 328848 8381 79407150
Urine analysis abnormal 13.48 9.61 5 328852 6515 79409016
Reduced facial expression 13.47 9.61 33 328824 2732 79412799
Drug effective for unapproved indication 13.46 9.61 4 328853 5997 79409534
Lip blister 13.46 9.61 33 328824 2734 79412797
Immune-mediated myositis 13.44 9.61 38 328819 3429 79412102
Aphasia 13.43 9.61 269 328588 46463 79369068
Microcytic anaemia 13.37 9.61 50 328807 5224 79410307
Visual field defect 13.32 9.61 73 328784 8972 79406559
Fibrinolysis increased 13.31 9.61 5 328852 27 79415504
Oral dysaesthesia 13.29 9.61 9 328848 192 79415339
Myelodysplastic syndrome 13.27 9.61 72 328785 30229 79385302
Multiple drug therapy 13.26 9.61 42 328815 4036 79411495
Spinal cord haemorrhage 13.25 9.61 14 328843 560 79414971
Nervousness 13.24 9.61 82 328775 33333 79382198
Pulmonary tuberculosis 13.24 9.61 8 328849 7857 79407674
Chronotropic incompetence 13.23 9.61 7 328850 93 79415438
Nightmare 13.23 9.61 164 328693 25697 79389834
Upper gastrointestinal haemorrhage 13.20 9.61 242 328615 41138 79374393
Acute myeloid leukaemia 13.19 9.61 74 328783 30811 79384720
Peritonitis bacterial 13.17 9.61 12 328845 9555 79405976
Right ventricular failure 13.17 9.61 51 328806 23446 79392085
Nitritoid reaction 13.16 9.61 5 328852 28 79415503
Aortic arteriosclerosis 13.15 9.61 72 328785 8846 79406685
Monoparesis 13.15 9.61 38 328819 3473 79412058
Resuscitation 13.13 9.61 30 328827 2374 79413157
Hypertension 13.10 9.61 1558 327299 329434 79086097
Hallucination 13.08 9.61 454 328403 85291 79330240
Renal disorder 12.98 9.61 111 328746 41994 79373537
Haemorrhagic stroke 12.96 9.61 84 328773 10962 79404569
Colorectal cancer 12.95 9.61 10 328847 8637 79406894
Immune effector cell-associated neurotoxicity syndrome 12.93 9.61 4 328853 5844 79409687
Drug-disease interaction 12.92 9.61 19 328838 1068 79414463
N-terminal prohormone brain natriuretic peptide abnormal 12.90 9.61 10 328847 265 79415266
Hypercapnic coma 12.86 9.61 12 328845 412 79415119
Oral neoplasm 12.86 9.61 8 328849 147 79415384
Bronchomalacia 12.84 9.61 10 328847 267 79415264
Pseudocyst 12.84 9.61 11 328846 337 79415194
Fibromyalgia 12.84 9.61 352 328505 63988 79351543
Catarrh 12.82 9.61 28 328829 2150 79413381
Brain oedema 12.81 9.61 57 328800 25206 79390325
Mitral valve thickening 12.79 9.61 12 328845 415 79415116
Foot fracture 12.78 9.61 47 328810 21934 79393597
Progressive multifocal leukoencephalopathy 12.68 9.61 43 328814 20557 79394974
Micturition disorder 12.66 9.61 41 328816 3987 79411544
Oral candidiasis 12.65 9.61 71 328786 29557 79385974
Suicidal ideation 12.63 9.61 230 328627 76110 79339421
Pseudomonas infection 12.61 9.61 44 328813 20859 79394672
Blood immunoglobulin A decreased 12.61 9.61 22 328835 1431 79414100
Mean cell haemoglobin decreased 12.59 9.61 55 328802 6169 79409362
SARS-CoV-2 test positive 12.54 9.61 18 328839 11698 79403833
Enlarged uvula 12.48 9.61 12 328845 428 79415103
Oropharyngeal discomfort 12.47 9.61 7 328850 7159 79408372
Intermittent claudication 12.45 9.61 37 328820 3434 79412097
Serotonin syndrome 12.45 9.61 122 328735 44905 79370626
Renal-limited thrombotic microangiopathy 12.44 9.61 8 328849 156 79415375
Cutaneous vasculitis 12.42 9.61 67 328790 8185 79407346
Accessory spleen 12.41 9.61 9 328848 215 79415316
Peripheral arterial occlusive disease 12.40 9.61 67 328790 8191 79407340
Dyspnoea paroxysmal nocturnal 12.39 9.61 28 328829 2200 79413331
Parainfluenzae virus infection 12.36 9.61 4 328853 5678 79409853
Therapeutic drug monitoring analysis incorrectly performed 12.33 9.61 15 328842 701 79414830
Injection site haemorrhage 12.33 9.61 66 328791 27804 79387727
Precancerous skin lesion 12.32 9.61 21 328836 1340 79414191
Febrile infection 12.32 9.61 36 328821 3310 79412221
Peripheral swelling 12.28 9.61 951 327906 268666 79146865
Hemianopia 12.27 9.61 24 328833 1704 79413827
Enthesopathy 12.27 9.61 18 328839 11590 79403941
Productive cough 12.26 9.61 274 328583 88057 79327474
Macrophage activation 12.25 9.61 4 328853 13 79415518
Ocular icterus 12.21 9.61 50 328807 5450 79410081
Computerised tomogram head abnormal 12.21 9.61 7 328850 110 79415421
Tongue biting 12.18 9.61 27 328830 2094 79413437
Coarctation of the aorta 12.18 9.61 6 328851 68 79415463
Enterocolitis 12.17 9.61 26 328831 14486 79401045
Parkinsonism 12.14 9.61 113 328744 16471 79399060
Lymphoproliferative disorder 12.13 9.61 4 328853 5611 79409920
Vulval cancer 12.12 9.61 13 328844 529 79415002
Nephrolithiasis 12.11 9.61 151 328706 53140 79362391
Genital infection female 12.10 9.61 6 328851 69 79415462
Body temperature decreased 12.07 9.61 193 328664 31952 79383579
Small fibre neuropathy 12.05 9.61 13 328844 533 79414998
Catatonia 12.04 9.61 11 328846 8745 79406786
Hepatitis B 12.02 9.61 10 328847 8322 79407209
Body temperature increased 12.01 9.61 121 328736 44299 79371232
Subclavian artery occlusion 12.01 9.61 8 328849 166 79415365
Hyperparathyroidism primary 11.97 9.61 12 328845 451 79415080
Menstruation irregular 11.96 9.61 3 328854 5033 79410498
Depression 11.96 9.61 752 328105 216038 79199493
Limb injury 11.94 9.61 72 328785 29456 79386075
Urinary retention 11.92 9.61 312 328545 56318 79359213
Oesophageal carcinoma 11.90 9.61 17 328840 11067 79404464
Mood swings 11.89 9.61 42 328815 19838 79395693
Emotional disorder 11.88 9.61 26 328831 14361 79401170
Kidney infection 11.88 9.61 48 328809 21803 79393728
Base excess decreased 11.86 9.61 11 328846 375 79415156
Joint injury 11.85 9.61 78 328779 31257 79384274
Brain stem ischaemia 11.85 9.61 10 328847 300 79415231
Amyloidosis 11.83 9.61 31 328826 2675 79412856
Splenic necrosis 11.80 9.61 8 328849 171 79415360
Incorrect dose administered by device 11.80 9.61 3 328854 4986 79410545
International normalised ratio decreased 11.80 9.61 65 328792 8005 79407526
Viral diarrhoea 11.78 9.61 11 328846 378 79415153
Liver function test increased 11.75 9.61 106 328751 39667 79375864
Multiple organ dysfunction syndrome 11.75 9.61 392 328465 119854 79295677
Hyperlactacidaemia 11.74 9.61 50 328807 5545 79409986
Pneumonia cytomegaloviral 11.73 9.61 3 328854 4966 79410565
Stoma site haemorrhage 11.70 9.61 25 328832 1891 79413640
Poor quality sleep 11.68 9.61 51 328806 22671 79392860
Vasculitic rash 11.65 9.61 27 328830 2157 79413374
Blood potassium decreased 11.64 9.61 129 328728 46383 79369148
Sensitisation 11.60 9.61 35 328822 3276 79412255
Cytomegalovirus test positive 11.57 9.61 5 328852 5942 79409589
Musculoskeletal deformity 11.52 9.61 22 328835 1534 79413997
Neuroglycopenia 11.52 9.61 12 328845 472 79415059
Hepatitis cholestatic 11.49 9.61 97 328760 13755 79401776
Macular degeneration 11.47 9.61 18 328839 11278 79404253
Ventricular internal diameter abnormal 11.47 9.61 9 328848 243 79415288
Cyst 11.44 9.61 25 328832 13815 79401716
Ankle fracture 11.44 9.61 34 328823 16935 79398596
Vasodilatation 11.43 9.61 34 328823 3157 79412374
Red blood cell sedimentation rate abnormal 11.43 9.61 46 328811 20917 79394614
Pacemaker generated arrhythmia 11.42 9.61 3 328854 3 79415528
Lymphostasis 11.42 9.61 4 328853 17 79415514
Agonal rhythm 11.39 9.61 6 328851 79 79415452
Glomerular filtration rate increased 11.38 9.61 19 328838 1192 79414339
Infusion site extravasation 11.35 9.61 15 328842 10093 79405438
Vaginal infection 11.35 9.61 5 328852 5875 79409656
Knee operation 11.31 9.61 5 328852 5861 79409670
Heat stroke 11.31 9.61 23 328834 1680 79413851
Eye injury 11.28 9.61 30 328827 2613 79412918
Arterial intramural haematoma 11.26 9.61 6 328851 81 79415450
Pneumonia fungal 11.25 9.61 18 328839 11192 79404339
Breath sounds abnormal 11.24 9.61 108 328749 15876 79399655
Duodenal ulcer perforation 11.24 9.61 355 328502 65856 79349675
Dysgeusia 11.19 9.61 167 328690 57010 79358521
Sensitivity to weather change 11.19 9.61 10 328847 8037 79407494
Hereditary angioedema 11.18 9.61 4 328853 5331 79410200
Rales 11.18 9.61 129 328728 19872 79395659
Sinus arrhythmia 11.16 9.61 26 328831 2084 79413447
Nodal arrhythmia 11.16 9.61 25 328832 1953 79413578
Paradoxical drug reaction 11.16 9.61 8 328849 7177 79408354
Sinoatrial block 11.13 9.61 20 328837 1331 79414200
Tooth infection 11.12 9.61 40 328817 18792 79396739
Facial bones fracture 11.12 9.61 46 328811 5036 79410495
Leukocyturia 11.12 9.61 25 328832 1958 79413573
Product preparation error 11.07 9.61 5 328852 5788 79409743
Shock haemorrhagic 11.04 9.61 129 328728 19931 79395600
Venous pressure jugular decreased 11.01 9.61 6 328851 85 79415446
Supine hypertension 10.98 9.61 11 328846 413 79415118
Tachycardia induced cardiomyopathy 10.97 9.61 8 328849 193 79415338
Relapsing multiple sclerosis 10.95 9.61 7 328850 135 79415396
Drug eruption 10.94 9.61 122 328735 43813 79371718
Clostridium difficile colitis 10.92 9.61 83 328774 32200 79383331
Anorgasmia 10.90 9.61 19 328838 1235 79414296
Apheresis related complication 10.90 9.61 4 328853 20 79415511
Alveolitis necrotising 10.90 9.61 4 328853 20 79415511
Cardiomyopathy 10.89 9.61 173 328684 28601 79386930
Oliguria 10.89 9.61 109 328748 16200 79399331
Therapeutic response decreased 10.88 9.61 202 328655 66651 79348880
Blood product transfusion dependent 10.83 9.61 11 328846 420 79415111
Endoscopy upper gastrointestinal tract 10.82 9.61 7 328850 138 79415393
Miller Fisher syndrome 10.81 9.61 9 328848 265 79415266
Peripheral circulatory failure 10.80 9.61 18 328839 1128 79414403
Altered state of consciousness 10.79 9.61 122 328735 43700 79371831
Genital paraesthesia 10.78 9.61 5 328852 49 79415482
Bacterial infection 10.78 9.61 80 328777 31200 79384331
Anal paraesthesia 10.74 9.61 4 328853 21 79415510
Disturbance in attention 10.73 9.61 280 328577 50521 79365010
Rheumatic disorder 10.71 9.61 33 328824 3125 79412406
Hyperprolactinaemia 10.70 9.61 3 328854 4673 79410858
Lipids abnormal 10.68 9.61 13 328844 608 79414923
Peripartum cardiomyopathy 10.65 9.61 7 328850 142 79415389
Atopy 10.64 9.61 11 328846 429 79415102
Skin infection 10.61 9.61 39 328818 18206 79397325
Aortic valve sclerosis 10.61 9.61 23 328834 1757 79413774
Blood cholinesterase decreased 10.61 9.61 9 328848 272 79415259
Bleeding time prolonged 10.60 9.61 19 328838 1262 79414269
Otitis media 10.58 9.61 6 328851 6100 79409431
Tuberculosis 10.57 9.61 30 328827 15168 79400363
Inadequate analgesia 10.54 9.61 3 328854 4626 79410905
Respiratory syncytial virus infection 10.51 9.61 14 328843 9388 79406143
Rabbit syndrome 10.49 9.61 10 328847 353 79415178
Ulcerative gastritis 10.48 9.61 6 328851 94 79415437
Chest wall haematoma 10.45 9.61 11 328846 438 79415093
Blood lactic acid increased 10.44 9.61 89 328768 12655 79402876
Asthma 10.42 9.61 453 328404 134642 79280889
Cerebellar haemorrhage 10.36 9.61 31 328826 2889 79412642
Fungal skin infection 10.36 9.61 6 328851 6030 79409501
Gastrointestinal angiodysplasia 10.35 9.61 17 328840 1052 79414479
Tubulointerstitial nephritis 10.30 9.61 218 328639 38017 79377514
Phalangeal hypoplasia 10.30 9.61 4 328853 24 79415507
Skin candida 10.27 9.61 25 328832 2062 79413469
Airway remodelling 10.25 9.61 9 328848 285 79415246
Troponin increased 10.24 9.61 123 328734 19132 79396399
Oxygen consumption decreased 10.23 9.61 11 328846 449 79415082
Blood test abnormal 10.21 9.61 38 328819 17672 79397859
Gastric ulcer haemorrhage 10.20 9.61 68 328789 8959 79406572
Fistula 10.19 9.61 24 328833 12916 79402615
Balanoposthitis 10.18 9.61 16 328841 954 79414577
Bone pain 10.17 9.61 165 328692 55577 79359954
Excessive eye blinking 10.16 9.61 22 328835 1679 79413852
Scleroderma 10.15 9.61 5 328852 5505 79410026
Infected skin ulcer 10.13 9.61 34 328823 3367 79412164
Accidental overdose 10.13 9.61 224 328633 39357 79376174
Left ventricular failure 10.13 9.61 71 328786 9510 79406021
Tendon rupture 10.10 9.61 85 328772 12041 79403490
Electrocardiogram QT shortened 10.10 9.61 8 328849 219 79415312
Herpes simplex 10.08 9.61 22 328835 12165 79403366
High density lipoprotein decreased 10.08 9.61 42 328815 4613 79410918
Tooth disorder 10.07 9.61 65 328792 26168 79389363
Plasma cell myeloma recurrent 10.06 9.61 4 328853 4997 79410534
Decreased immune responsiveness 10.04 9.61 5 328852 5470 79410061
Diabetic ketoacidotic hyperglycaemic coma 10.04 9.61 8 328849 221 79415310
Genital herpes simplex 10.04 9.61 10 328847 373 79415158
Gastrointestinal mucosal necrosis 10.01 9.61 8 328849 222 79415309
Arthropathy 10.00 9.61 613 328244 176498 79239033
Cystitis noninfective 9.99 9.61 19 328838 1321 79414210
Ear pain 9.97 9.61 87 328770 32782 79382749
Gastroenteritis eosinophilic 9.97 9.61 9 328848 296 79415235
Feeling jittery 9.96 9.61 24 328833 12817 79402714
Tendon pain 9.96 9.61 48 328809 5610 79409921
Feeding disorder 9.95 9.61 34 328823 16220 79399311
Urine abnormality 9.95 9.61 63 328794 8156 79407375
Anticoagulation drug level increased 9.93 9.61 14 328843 757 79414774
Blood immunoglobulin G increased 9.92 9.61 31 328826 2958 79412573
Bundle branch block 9.91 9.61 21 328836 1579 79413952
Gingival hypoplasia 9.90 9.61 3 328854 7 79415524
Diabetic foetopathy 9.90 9.61 4 328853 27 79415504
Pharyngitis 9.89 9.61 53 328804 22322 79393209
Blood glucose increased 9.86 9.61 574 328283 114401 79301130
Blood glucose abnormal 9.85 9.61 76 328781 10490 79405041
Bladder neoplasm 9.85 9.61 22 328835 1715 79413816
Normochromic normocytic anaemia 9.84 9.61 60 328797 7667 79407864
Eczema 9.82 9.61 229 328628 40589 79374942
Glycosylated haemoglobin increased 9.79 9.61 122 328735 19138 79396393
Blood calcium decreased 9.75 9.61 84 328773 31735 79383796
Type I hypersensitivity 9.74 9.61 3 328854 4395 79411136
Overflow diarrhoea 9.74 9.61 7 328850 165 79415366
Intestinal obstruction 9.73 9.61 122 328735 42898 79372633
Gastrointestinal pain 9.73 9.61 16 328841 9839 79405692
Sensory level abnormal 9.70 9.61 7 328850 166 79415365
Terminal state 9.69 9.61 4 328853 4885 79410646
Retinal vein thrombosis 9.67 9.61 13 328844 672 79414859
Optic nerve operation 9.66 9.61 11 328846 479 79415052
Pylorus dilatation 9.66 9.61 4 328853 29 79415502
Leptospirosis 9.66 9.61 4 328853 29 79415502
Encephalitis 9.64 9.61 30 328827 14730 79400801

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C09AA05 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, PLAIN
ACE inhibitors, plain
ATC C09BA05 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and diuretics
ATC C09BB05 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
ATC C09BB07 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
ATC C09BX03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C09BX05 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C10BX04 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX06 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX17 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX18 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
FDA MoA N0000000181 Angiotensin-converting Enzyme Inhibitors
FDA EPC N0000175562 Angiotensin Converting Enzyme Inhibitor
MeSH PA D000806 Angiotensin-Converting Enzyme Inhibitors
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011480 Protease Inhibitors
CHEBI has role CHEBI:35457 ACE inhibitor
CHEBI has role CHEBI:50266 Prodrugs
CHEBI has role CHEBI:50664 matrix metalloproteinase inhibitors
CHEBI has role CHEBI:77307 cardioprotective agents
CHEBI has role CHEBI:77496 bradykinin receptor B2 agonists
CHEBI has role CHEBI:49103 drug metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Chronic heart failure indication 48447003
Cerebrovascular accident indication 230690007
Left ventricular cardiac dysfunction indication 429589006
Myocardial Infarction Prevention indication
Atrial fibrillation off-label use 49436004 DOID:0060224
Diabetic renal disease off-label use 127013003
Acute scleroderma renal crisis off-label use 236503001
Diastolic heart failure off-label use 418304008 DOID:9775
Hypertension due to Scleroderma off-label use
Nondiabetic Proteinuric Nephropathy off-label use
Hyperkalemia contraindication 14140009
Acute vomiting contraindication 23971007
Dehydration contraindication 34095006
Low blood pressure contraindication 45007003
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Hereditary angioneurotic edema contraindication 82966003 DOID:14735
Oliguria contraindication 83128009
Systemic sclerosis contraindication 89155008 DOID:418
Hyponatremia contraindication 89627008
Kidney disease contraindication 90708001 DOID:557
Disorder of connective tissue contraindication 105969002 DOID:65
Liver function tests abnormal contraindication 166603001
Hyposensitization to allergens contraindication 182678001
Disease of liver contraindication 235856003 DOID:409
Renal dialysis contraindication 265764009
Pregnancy, function contraindication 289908002
Renal artery stenosis contraindication 302233006
Neutropenic disorder contraindication 303011007 DOID:1227
Severe diarrhea contraindication 409587002
Azotemia contraindication 445009001
Head and Neck Angioedema contraindication
Intestinal Angioedema contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.21 acidic
pKa2 5.77 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Angiotensin-converting enzyme Enzyme INHIBITOR Ki 8.34 WOMBAT-PK CHEMBL
Angiotensin-converting enzyme Enzyme IC50 6.60 CHEMBL

External reference:

IDSource
4019562 VUID
N0000147662 NUI
D00421 KEGG_DRUG
4019562 VANDF
C0072973 UMLSCUI
CHEBI:8774 CHEBI
CHEBI:77363 CHEBI
X92 PDB_CHEM_ID
CHEMBL1168 ChEMBL_ID
D017257 MESH_DESCRIPTOR_UI
DB00178 DRUGBANK_ID
5362129 PUBCHEM_CID
6339 IUPHAR_LIGAND_ID
C052549 MESH_SUPPLEMENTAL_RECORD_UI
5561 INN_ID
L35JN3I7SJ UNII
DB14208 DRUGBANK_ID
1546377 RXNORM
130231 MMSL
5411 MMSL
d00728 MMSL
003585 NDDF
108564000 SNOMEDCT_US
386872004 SNOMEDCT_US
C0072970 UMLSCUI
CHEMBL1201365 ChEMBL_ID
5713 INN_ID
87269-97-4 SECONDARY_CAS_RN
5464096 PUBCHEM_CID
6344 IUPHAR_LIGAND_ID
6N5U4QFC3G UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 0054-0106 CAPSULE 1.25 mg ORAL ANDA 26 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 0054-0107 CAPSULE 2.50 mg ORAL ANDA 26 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 0054-0108 CAPSULE 5 mg ORAL ANDA 26 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 0054-0109 CAPSULE 10 mg ORAL ANDA 26 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 10544-588 CAPSULE 10 mg ORAL ANDA 27 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 16729-152 CAPSULE 1.25 mg ORAL ANDA 28 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 16729-153 CAPSULE 2.50 mg ORAL ANDA 28 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 16729-154 CAPSULE 5 mg ORAL ANDA 28 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 16729-155 CAPSULE 10 mg ORAL ANDA 28 sections
RAMIPRIL HUMAN PRESCRIPTION DRUG LABEL 1 17856-0108 CAPSULE 5 mg ORAL ANDA 25 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 21695-821 CAPSULE 2.50 mg ORAL ANDA 20 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 21695-822 CAPSULE 5 mg ORAL ANDA 20 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 21695-823 CAPSULE 10 mg ORAL ANDA 20 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 31722-271 CAPSULE 1.25 mg ORAL ANDA 26 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 31722-272 CAPSULE 2.50 mg ORAL ANDA 26 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 31722-273 CAPSULE 5 mg ORAL ANDA 26 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 31722-274 CAPSULE 10 mg ORAL ANDA 26 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 33261-903 CAPSULE 5 mg ORAL ANDA 27 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 33261-967 CAPSULE 10 mg ORAL ANDA 27 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 45865-441 CAPSULE 10 mg ORAL ANDA 28 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 45865-443 CAPSULE 5 mg ORAL ANDA 27 sections
Ramipril Human Prescription Drug Label 1 50090-1118 CAPSULE 5 mg ORAL ANDA 27 sections
Ramipril Human Prescription Drug Label 1 50090-1120 CAPSULE 10 mg ORAL ANDA 27 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 50090-3059 CAPSULE 2.50 mg ORAL ANDA 23 sections
Ramipril Human Prescription Drug Label 1 50090-3873 CAPSULE 2.50 mg ORAL ANDA 27 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 50090-4597 CAPSULE 5 mg ORAL ANDA 23 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 50090-4691 CAPSULE 10 mg ORAL ANDA 23 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 50090-4691 CAPSULE 10 mg ORAL ANDA 23 sections
Ramipril Human Prescription Drug Label 1 50090-5673 CAPSULE 5 mg ORAL ANDA 26 sections
Ramipril Human Prescription Drug Label 1 50090-5673 CAPSULE 5 mg ORAL ANDA 26 sections