rabeprazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antiulcer, benzimidazole derivatives | 2350 | 117976-89-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 20 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 0 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 1.50 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 52 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.22 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 4 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.04 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 1 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Aug. 19, 1999 | FDA | EISAI INC |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Obstructive airways disorder | 228.73 | 9.95 | 177 | 61328 | 20522 | 63406995 |
| Eosinophilic bronchitis | 221.56 | 9.95 | 60 | 61445 | 513 | 63427004 |
| Eosinophil count increased | 216.84 | 9.95 | 134 | 61371 | 10794 | 63416723 |
| Pemphigus | 159.05 | 9.95 | 4 | 61501 | 183722 | 63243795 |
| Reversible airways obstruction | 145.73 | 9.95 | 58 | 61447 | 1784 | 63425733 |
| Vital capacity decreased | 142.27 | 9.95 | 56 | 61449 | 1672 | 63425845 |
| Sputum culture positive | 136.62 | 9.95 | 58 | 61447 | 2109 | 63425408 |
| Maternal exposure during pregnancy | 134.89 | 9.95 | 25 | 61480 | 220037 | 63207480 |
| Bronchial secretion retention | 125.98 | 9.95 | 59 | 61446 | 2714 | 63424803 |
| Neutrophilia | 116.30 | 9.95 | 65 | 61440 | 4341 | 63423176 |
| Oral discomfort | 111.15 | 9.95 | 83 | 61422 | 9118 | 63418399 |
| Full blood count abnormal | 104.66 | 9.95 | 141 | 61364 | 31576 | 63395941 |
| Gastrooesophageal reflux disease | 103.24 | 9.95 | 262 | 61243 | 95377 | 63332140 |
| Synovitis | 102.89 | 9.95 | 27 | 61478 | 186891 | 63240626 |
| Polyp | 102.32 | 9.95 | 69 | 61436 | 6452 | 63421065 |
| Glossodynia | 100.06 | 9.95 | 25 | 61480 | 178851 | 63248666 |
| Hand deformity | 97.93 | 9.95 | 18 | 61487 | 159439 | 63268078 |
| Pericarditis | 97.44 | 9.95 | 8 | 61497 | 131571 | 63295946 |
| Loss of employment | 96.59 | 9.95 | 46 | 61459 | 2198 | 63425319 |
| Alopecia | 93.23 | 9.95 | 114 | 61391 | 337422 | 63090095 |
| Wound | 92.92 | 9.95 | 22 | 61483 | 163241 | 63264276 |
| Completed suicide | 90.42 | 9.95 | 16 | 61489 | 145657 | 63281860 |
| Anti-cyclic citrullinated peptide antibody positive | 83.52 | 9.95 | 8 | 61497 | 116204 | 63311313 |
| Systemic lupus erythematosus | 82.67 | 9.95 | 50 | 61455 | 208868 | 63218649 |
| Multiple allergies | 81.95 | 9.95 | 83 | 61422 | 13719 | 63413798 |
| Hepatic function abnormal | 75.63 | 9.95 | 132 | 61373 | 37010 | 63390507 |
| Nasal disorder | 72.20 | 9.95 | 41 | 61464 | 2823 | 63424694 |
| Upper-airway cough syndrome | 72.10 | 9.95 | 71 | 61434 | 11347 | 63416170 |
| Discomfort | 66.28 | 9.95 | 40 | 61465 | 167334 | 63260183 |
| Duodenal ulcer perforation | 65.40 | 9.95 | 5 | 61500 | 87204 | 63340313 |
| Interstitial lung disease | 65.12 | 9.95 | 168 | 61337 | 61740 | 63365777 |
| Gastric disorder | 62.48 | 9.95 | 122 | 61383 | 37247 | 63390270 |
| Toxicity to various agents | 61.61 | 9.95 | 90 | 61415 | 247160 | 63180357 |
| Rheumatoid factor positive | 60.14 | 9.95 | 6 | 61499 | 84400 | 63343117 |
| Hepatic steatosis | 59.56 | 9.95 | 103 | 61402 | 28666 | 63398851 |
| Sputum purulent | 58.43 | 9.95 | 26 | 61479 | 1061 | 63426456 |
| Nicotine dependence | 58.20 | 9.95 | 23 | 61482 | 694 | 63426823 |
| Hypomagnesaemia | 57.04 | 9.95 | 101 | 61404 | 28636 | 63398881 |
| Tonsillar disorder | 56.96 | 9.95 | 26 | 61479 | 1127 | 63426390 |
| Product dose omission issue | 56.72 | 9.95 | 87 | 61418 | 234226 | 63193291 |
| Exposure during pregnancy | 56.42 | 9.95 | 41 | 61464 | 155506 | 63272011 |
| Secondary immunodeficiency | 55.44 | 9.95 | 27 | 61478 | 1356 | 63426161 |
| Drug abuse | 54.82 | 9.95 | 4 | 61501 | 72514 | 63355003 |
| Death | 54.08 | 9.95 | 184 | 61321 | 374197 | 63053320 |
| Pulmonary mass | 53.60 | 9.95 | 86 | 61419 | 22510 | 63405007 |
| Gastric polyps | 53.35 | 9.95 | 36 | 61469 | 3369 | 63424148 |
| Asthma | 52.72 | 9.95 | 254 | 61251 | 127307 | 63300210 |
| Helicobacter infection | 49.90 | 9.95 | 14 | 61491 | 92771 | 63334746 |
| Colitis microscopic | 49.76 | 9.95 | 53 | 61452 | 9286 | 63418231 |
| Hiatus hernia | 46.92 | 9.95 | 79 | 61426 | 21515 | 63406002 |
| Bacterial infection | 45.96 | 9.95 | 74 | 61431 | 19425 | 63408092 |
| Cough | 45.37 | 9.95 | 458 | 61047 | 292285 | 63135232 |
| Cestode infection | 45.10 | 9.95 | 15 | 61490 | 272 | 63427245 |
| Cholecystitis chronic | 43.59 | 9.95 | 52 | 61453 | 10309 | 63417208 |
| Lichen sclerosus | 39.56 | 9.95 | 20 | 61485 | 1089 | 63426428 |
| Rheumatoid arthritis | 39.26 | 9.95 | 397 | 61108 | 253422 | 63174095 |
| Pneumothorax spontaneous | 38.68 | 9.95 | 18 | 61487 | 816 | 63426701 |
| Drug eruption | 37.83 | 9.95 | 85 | 61420 | 28609 | 63398908 |
| Platelet count decreased | 37.50 | 9.95 | 216 | 61289 | 115906 | 63311611 |
| Respiratory tract infection | 36.07 | 9.95 | 105 | 61400 | 41378 | 63386139 |
| Hypertonic bladder | 36.00 | 9.95 | 29 | 61476 | 3559 | 63423958 |
| Lung diffusion test decreased | 35.30 | 9.95 | 16 | 61489 | 682 | 63426835 |
| Arthropathy | 34.81 | 9.95 | 114 | 61391 | 234678 | 63192839 |
| Erythema multiforme | 34.75 | 9.95 | 46 | 61459 | 10123 | 63417394 |
| Magnesium deficiency | 34.54 | 9.95 | 15 | 61490 | 577 | 63426940 |
| Fatigue | 34.45 | 9.95 | 630 | 60875 | 887398 | 62540119 |
| Myocardial infarction | 32.37 | 9.95 | 186 | 61319 | 99707 | 63327810 |
| Tubulointerstitial nephritis | 32.08 | 9.95 | 64 | 61441 | 19839 | 63407678 |
| Blood pressure fluctuation | 31.77 | 9.95 | 108 | 61397 | 46209 | 63381308 |
| Premenstrual syndrome | 31.74 | 9.95 | 15 | 61490 | 704 | 63426813 |
| Enterocolitis haemorrhagic | 31.70 | 9.95 | 19 | 61486 | 1447 | 63426070 |
| Neutrophil count decreased | 31.48 | 9.95 | 123 | 61382 | 56283 | 63371234 |
| Polymyalgia rheumatica | 30.54 | 9.95 | 27 | 61478 | 3764 | 63423753 |
| Sputum culture | 30.23 | 9.95 | 11 | 61494 | 263 | 63427254 |
| Malignant polyp | 30.08 | 9.95 | 10 | 61495 | 181 | 63427336 |
| Treatment failure | 29.25 | 9.95 | 97 | 61408 | 198946 | 63228571 |
| Drug intolerance | 28.80 | 9.95 | 178 | 61327 | 308483 | 63119034 |
| Liver disorder | 28.30 | 9.95 | 115 | 61390 | 53572 | 63373945 |
| Lip pruritus | 27.83 | 9.95 | 15 | 61490 | 932 | 63426585 |
| Tubulointerstitial nephritis and uveitis syndrome | 27.65 | 9.95 | 10 | 61495 | 235 | 63427282 |
| Hypertension | 27.47 | 9.95 | 401 | 61104 | 278902 | 63148615 |
| C-reactive protein abnormal | 26.62 | 9.95 | 6 | 61499 | 46090 | 63381427 |
| Limb mass | 26.00 | 9.95 | 23 | 61482 | 3209 | 63424308 |
| Hypokalaemia | 25.99 | 9.95 | 181 | 61324 | 103623 | 63323894 |
| Hypereosinophilic syndrome | 25.81 | 9.95 | 10 | 61495 | 286 | 63427231 |
| Adenocarcinoma | 25.76 | 9.95 | 22 | 61483 | 2928 | 63424589 |
| Cardiac failure | 25.69 | 9.95 | 161 | 61344 | 88981 | 63338536 |
| Product use issue | 25.66 | 9.95 | 118 | 61387 | 220402 | 63207115 |
| Hepatic enzyme increased | 25.53 | 9.95 | 105 | 61400 | 202223 | 63225294 |
| Abdominal distension | 25.32 | 9.95 | 157 | 61348 | 86458 | 63341059 |
| Intra-abdominal fluid collection | 25.16 | 9.95 | 20 | 61485 | 2409 | 63425108 |
| Renal impairment | 25.11 | 9.95 | 159 | 61346 | 88196 | 63339321 |
| Malaise | 24.55 | 9.95 | 551 | 60954 | 415403 | 63012114 |
| Hyponatraemia | 24.52 | 9.95 | 189 | 61316 | 111711 | 63315806 |
| Blood pressure increased | 24.32 | 9.95 | 252 | 61253 | 161810 | 63265707 |
| Polymenorrhoea | 24.29 | 9.95 | 15 | 61490 | 1206 | 63426311 |
| Blood pressure diastolic decreased | 24.26 | 9.95 | 62 | 61443 | 22644 | 63404873 |
| Cerebral infarction | 24.25 | 9.95 | 64 | 61441 | 23829 | 63403688 |
| Body temperature fluctuation | 24.06 | 9.95 | 19 | 61486 | 2266 | 63425251 |
| Cardiac failure congestive | 23.63 | 9.95 | 162 | 61343 | 92271 | 63335246 |
| Biliary dyskinesia | 23.12 | 9.95 | 20 | 61485 | 2709 | 63424808 |
| Non-economic loss | 22.79 | 9.95 | 5 | 61500 | 15 | 63427502 |
| Barotrauma | 22.44 | 9.95 | 8 | 61497 | 180 | 63427337 |
| Upper respiratory tract inflammation | 22.41 | 9.95 | 19 | 61486 | 2504 | 63425013 |
| Abdominal pain | 22.38 | 9.95 | 404 | 61101 | 293052 | 63134465 |
| Red cell distribution width increased | 22.20 | 9.95 | 38 | 61467 | 10486 | 63417031 |
| Chronic kidney disease | 22.17 | 9.95 | 95 | 61410 | 45303 | 63382214 |
| Menstruation delayed | 21.79 | 9.95 | 16 | 61489 | 1713 | 63425804 |
| Focal segmental glomerulosclerosis | 21.76 | 9.95 | 15 | 61490 | 1453 | 63426064 |
| Hepatitis chronic active | 21.59 | 9.95 | 6 | 61499 | 57 | 63427460 |
| Neutropenia | 21.35 | 9.95 | 92 | 61413 | 174913 | 63252604 |
| Abdominal pain upper | 21.32 | 9.95 | 299 | 61206 | 206145 | 63221372 |
| Retinal toxicity | 21.23 | 9.95 | 14 | 61491 | 1261 | 63426256 |
| Lip infection | 21.10 | 9.95 | 7 | 61498 | 126 | 63427391 |
| Hepatotoxicity | 21.04 | 9.95 | 5 | 61500 | 37036 | 63390481 |
| Adverse event | 20.59 | 9.95 | 21 | 61484 | 67538 | 63359979 |
| Akathisia | 20.59 | 9.95 | 34 | 61471 | 9112 | 63418405 |
| Eosinophil count decreased | 20.50 | 9.95 | 17 | 61488 | 2173 | 63425344 |
| Irritable bowel syndrome | 20.49 | 9.95 | 30 | 61475 | 82382 | 63345135 |
| Blood alkaline phosphatase increased | 20.28 | 9.95 | 89 | 61416 | 42878 | 63384639 |
| Blister | 19.94 | 9.95 | 62 | 61443 | 129752 | 63297765 |
| Infection | 19.92 | 9.95 | 135 | 61370 | 229038 | 63198479 |
| Gamma-glutamyltransferase increased | 19.63 | 9.95 | 75 | 61430 | 33956 | 63393561 |
| Aortic dissection | 19.59 | 9.95 | 16 | 61489 | 2002 | 63425515 |
| Blood pressure systolic increased | 19.28 | 9.95 | 94 | 61411 | 47303 | 63380214 |
| Hypocalcaemia | 19.21 | 9.95 | 71 | 61434 | 31642 | 63395875 |
| Intervertebral disc degeneration | 18.97 | 9.95 | 45 | 61460 | 15687 | 63411830 |
| Foetal exposure during pregnancy | 18.78 | 9.95 | 4 | 61501 | 31958 | 63395559 |
| Inflammation | 18.60 | 9.95 | 140 | 61365 | 82133 | 63345384 |
| Radioallergosorbent test positive | 18.54 | 9.95 | 5 | 61500 | 42 | 63427475 |
| Clitoris abscess | 18.49 | 9.95 | 4 | 61501 | 11 | 63427506 |
| Aspartate aminotransferase increased | 18.41 | 9.95 | 150 | 61355 | 90127 | 63337390 |
| Condition aggravated | 18.23 | 9.95 | 277 | 61228 | 401940 | 63025577 |
| Fall | 18.15 | 9.95 | 503 | 61002 | 391831 | 63035686 |
| Multiple fractures | 18.02 | 9.95 | 31 | 61474 | 8587 | 63418930 |
| Arthralgia | 18 | 9.95 | 698 | 60807 | 569012 | 62858505 |
| Peripheral swelling | 17.87 | 9.95 | 168 | 61337 | 265774 | 63161743 |
| Coeliac artery occlusion | 17.82 | 9.95 | 3 | 61502 | 0 | 63427517 |
| Intentional product use issue | 17.65 | 9.95 | 64 | 61441 | 127828 | 63299689 |
| Lower respiratory tract infection viral | 17.52 | 9.95 | 11 | 61494 | 910 | 63426607 |
| Premature delivery | 17.37 | 9.95 | 4 | 61501 | 30277 | 63397240 |
| Blood pressure decreased | 17.24 | 9.95 | 115 | 61390 | 64907 | 63362610 |
| Dysstasia | 16.90 | 9.95 | 52 | 61453 | 21114 | 63406403 |
| Prescribed overdose | 16.85 | 9.95 | 6 | 61499 | 34147 | 63393370 |
| Hip arthroplasty | 16.69 | 9.95 | 13 | 61492 | 47633 | 63379884 |
| Therapy non-responder | 16.65 | 9.95 | 30 | 61475 | 75871 | 63351646 |
| Abdominal tenderness | 16.59 | 9.95 | 29 | 61476 | 8137 | 63419380 |
| Swelling | 16.41 | 9.95 | 179 | 61326 | 275199 | 63152318 |
| Heart rate increased | 16.31 | 9.95 | 151 | 61354 | 94087 | 63333430 |
| Dysphonia | 16.30 | 9.95 | 90 | 61415 | 47524 | 63379993 |
| Q fever | 16.20 | 9.95 | 6 | 61499 | 151 | 63427366 |
| Oral discharge | 15.84 | 9.95 | 6 | 61499 | 161 | 63427356 |
| Rib fracture | 15.76 | 9.95 | 53 | 61452 | 22544 | 63404973 |
| Sedation | 15.74 | 9.95 | 9 | 61496 | 38800 | 63388717 |
| Impaired healing | 15.73 | 9.95 | 49 | 61456 | 102493 | 63325024 |
| Therapy cessation | 15.63 | 9.95 | 5 | 61500 | 30452 | 63397065 |
| Overdose | 15.61 | 9.95 | 58 | 61447 | 115020 | 63312497 |
| Abdominal discomfort | 15.57 | 9.95 | 218 | 61287 | 320667 | 63106850 |
| Rubella | 15.50 | 9.95 | 6 | 61499 | 171 | 63427346 |
| Gallbladder injury | 15.35 | 9.95 | 12 | 61493 | 1411 | 63426106 |
| Lower limb fracture | 15.33 | 9.95 | 55 | 61450 | 24166 | 63403351 |
| Intentional product misuse | 15.32 | 9.95 | 22 | 61483 | 60895 | 63366622 |
| Infusion related reaction | 15.27 | 9.95 | 158 | 61347 | 245363 | 63182154 |
| Spinal compression fracture | 15.26 | 9.95 | 39 | 61466 | 14244 | 63413273 |
| Erosive oesophagitis | 15.18 | 9.95 | 13 | 61492 | 1737 | 63425780 |
| Emphysema | 15.09 | 9.95 | 33 | 61472 | 10905 | 63416612 |
| Iron deficiency anaemia | 14.97 | 9.95 | 48 | 61457 | 19921 | 63407596 |
| No adverse event | 14.89 | 9.95 | 11 | 61494 | 41394 | 63386123 |
| Gastric mucosal lesion | 14.86 | 9.95 | 8 | 61497 | 496 | 63427021 |
| Hypercholesterolaemia | 14.85 | 9.95 | 50 | 61455 | 21284 | 63406233 |
| Serum sickness | 14.83 | 9.95 | 16 | 61489 | 2844 | 63424673 |
| Pulmonary function test abnormal | 14.68 | 9.95 | 13 | 61492 | 1817 | 63425700 |
| Hepatocellular carcinoma | 14.52 | 9.95 | 14 | 61491 | 2180 | 63425337 |
| Knee arthroplasty | 14.21 | 9.95 | 19 | 61486 | 54187 | 63373330 |
| Chorioretinal disorder | 14.17 | 9.95 | 5 | 61500 | 109 | 63427408 |
| Disease progression | 14.08 | 9.95 | 66 | 61439 | 122692 | 63304825 |
| Microcytic anaemia | 14.08 | 9.95 | 17 | 61488 | 3412 | 63424105 |
| Gastric cancer | 14.08 | 9.95 | 20 | 61485 | 4703 | 63422814 |
| Alanine aminotransferase increased | 14.00 | 9.95 | 158 | 61347 | 103612 | 63323905 |
| Gastric volvulus | 13.93 | 9.95 | 3 | 61502 | 8 | 63427509 |
| Off label use | 13.89 | 9.95 | 524 | 60981 | 673938 | 62753579 |
| Hyperthyroidism | 13.59 | 9.95 | 38 | 61467 | 14635 | 63412882 |
| Disseminated intravascular coagulation | 13.57 | 9.95 | 45 | 61460 | 19006 | 63408511 |
| Macule | 13.53 | 9.95 | 13 | 61492 | 2015 | 63425502 |
| Suicide attempt | 13.43 | 9.95 | 24 | 61481 | 60894 | 63366623 |
| Heat stroke | 13.37 | 9.95 | 9 | 61496 | 839 | 63426678 |
| Gastric antral vascular ectasia | 13.23 | 9.95 | 8 | 61497 | 619 | 63426898 |
| Intentional overdose | 13.18 | 9.95 | 33 | 61472 | 74119 | 63353398 |
| Uveitis | 13.12 | 9.95 | 34 | 61471 | 12519 | 63414998 |
| Gastritis | 13.10 | 9.95 | 71 | 61434 | 37232 | 63390285 |
| Pneumonia aspiration | 12.99 | 9.95 | 67 | 61438 | 34473 | 63393044 |
| Giardiasis | 12.98 | 9.95 | 4 | 61501 | 56 | 63427461 |
| Product use in unapproved indication | 12.95 | 9.95 | 111 | 61394 | 178969 | 63248548 |
| Restrictive pulmonary disease | 12.92 | 9.95 | 12 | 61493 | 1783 | 63425734 |
| Melaena | 12.91 | 9.95 | 61 | 61444 | 30304 | 63397213 |
| Productive cough | 12.87 | 9.95 | 105 | 61400 | 63103 | 63364414 |
| Gingival pain | 12.86 | 9.95 | 26 | 61479 | 8136 | 63419381 |
| Liver iron concentration abnormal | 12.86 | 9.95 | 4 | 61501 | 58 | 63427459 |
| Tibia fracture | 12.85 | 9.95 | 20 | 61485 | 5100 | 63422417 |
| Mucosal inflammation | 12.76 | 9.95 | 16 | 61489 | 46912 | 63380605 |
| Cystitis | 12.67 | 9.95 | 94 | 61411 | 54897 | 63372620 |
| Tooth fracture | 12.56 | 9.95 | 31 | 61474 | 11079 | 63416438 |
| Auricular swelling | 12.55 | 9.95 | 4 | 61501 | 63 | 63427454 |
| Haemoglobin decreased | 12.41 | 9.95 | 204 | 61301 | 145281 | 63282236 |
| Confusional state | 12.40 | 9.95 | 158 | 61347 | 236222 | 63191295 |
| Anaemia | 12.39 | 9.95 | 372 | 61133 | 293058 | 63134459 |
| Haemolytic anaemia | 12.25 | 9.95 | 29 | 61476 | 10096 | 63417421 |
| Vaccination site pain | 12.15 | 9.95 | 5 | 61500 | 168 | 63427349 |
| Hypochromic anaemia | 12.12 | 9.95 | 12 | 61493 | 1930 | 63425587 |
| Medication error | 12.07 | 9.95 | 20 | 61485 | 52264 | 63375253 |
| Hypercapnia | 11.97 | 9.95 | 20 | 61485 | 5411 | 63422106 |
| Forced expiratory volume decreased | 11.91 | 9.95 | 19 | 61486 | 4949 | 63422568 |
| Mean cell haemoglobin concentration decreased | 11.82 | 9.95 | 16 | 61489 | 3596 | 63423921 |
| Adenocarcinoma gastric | 11.80 | 9.95 | 7 | 61498 | 523 | 63426994 |
| Sinusitis | 11.70 | 9.95 | 152 | 61353 | 226501 | 63201016 |
| Wrong technique in product usage process | 11.67 | 9.95 | 27 | 61478 | 62313 | 63365204 |
| Accidental exposure to product | 11.63 | 9.95 | 6 | 61499 | 27399 | 63400118 |
| Adverse drug reaction | 11.59 | 9.95 | 39 | 61466 | 79675 | 63347842 |
| General physical health deterioration | 11.56 | 9.95 | 132 | 61373 | 201270 | 63226247 |
| Pseudocholinesterase deficiency | 11.48 | 9.95 | 4 | 61501 | 84 | 63427433 |
| Premature baby | 11.39 | 9.95 | 3 | 61502 | 20732 | 63406785 |
| Gastric dysplasia | 11.37 | 9.95 | 3 | 61502 | 23 | 63427494 |
| Pain in extremity | 11.36 | 9.95 | 410 | 61095 | 331076 | 63096441 |
| Skin injury | 11.28 | 9.95 | 11 | 61494 | 1737 | 63425780 |
| Gallbladder disorder | 11.26 | 9.95 | 42 | 61463 | 18800 | 63408717 |
| Injection site erythema | 11.22 | 9.95 | 42 | 61463 | 83132 | 63344385 |
| Contraindicated product administered | 11.22 | 9.95 | 146 | 61359 | 217502 | 63210015 |
| Enteritis infectious | 11.22 | 9.95 | 12 | 61493 | 2112 | 63425405 |
| Injection site swelling | 11.17 | 9.95 | 18 | 61487 | 47554 | 63379963 |
| Joint space narrowing | 11.09 | 9.95 | 7 | 61498 | 585 | 63426932 |
| Gastrointestinal polyp haemorrhage | 11.01 | 9.95 | 5 | 61500 | 214 | 63427303 |
| Blood pressure systolic decreased | 10.99 | 9.95 | 23 | 61482 | 7374 | 63420143 |
| Gastrointestinal bacterial infection | 10.98 | 9.95 | 8 | 61497 | 846 | 63426671 |
| Femoral neck fracture | 10.96 | 9.95 | 25 | 61480 | 8498 | 63419019 |
| Unresponsive to stimuli | 10.90 | 9.95 | 10 | 61495 | 33806 | 63393711 |
| Intertrigo | 10.83 | 9.95 | 7 | 61498 | 609 | 63426908 |
| Ascites | 10.77 | 9.95 | 72 | 61433 | 40656 | 63386861 |
| Sleep disorder due to a general medical condition | 10.73 | 9.95 | 31 | 61474 | 12157 | 63415360 |
| Pneumonia | 10.72 | 9.95 | 543 | 60962 | 456224 | 62971293 |
| Compression fracture | 10.71 | 9.95 | 21 | 61484 | 6427 | 63421090 |
| Liver injury | 10.70 | 9.95 | 27 | 61478 | 60493 | 63367024 |
| Overlap syndrome | 10.64 | 9.95 | 8 | 61497 | 888 | 63426629 |
| Colon cancer | 10.58 | 9.95 | 27 | 61478 | 9851 | 63417666 |
| Stress at work | 10.54 | 9.95 | 9 | 61496 | 1198 | 63426319 |
| Prescribed underdose | 10.53 | 9.95 | 8 | 61497 | 29681 | 63397836 |
| Inflammatory pain | 10.51 | 9.95 | 8 | 61497 | 904 | 63426613 |
| Idiopathic interstitial pneumonia | 10.48 | 9.95 | 3 | 61502 | 32 | 63427485 |
| Pancreatic neuroendocrine tumour | 10.41 | 9.95 | 6 | 61499 | 425 | 63427092 |
| Superficial injury of eye | 10.40 | 9.95 | 5 | 61500 | 244 | 63427273 |
| Catheter site hypersensitivity | 10.37 | 9.95 | 4 | 61501 | 113 | 63427404 |
| Alternaria infection | 10.36 | 9.95 | 5 | 61500 | 246 | 63427271 |
| Beta-N-acetyl-D-glucosaminidase increased | 10.32 | 9.95 | 3 | 61502 | 34 | 63427483 |
| Pharyngeal oedema | 10.30 | 9.95 | 33 | 61472 | 13688 | 63413829 |
| Swollen tongue | 10.11 | 9.95 | 63 | 61442 | 34737 | 63392780 |
| Generalised oedema | 10.08 | 9.95 | 36 | 61469 | 15782 | 63411735 |
| Enterocolitis | 10.05 | 9.95 | 23 | 61482 | 7835 | 63419682 |
| Neck pain | 10.01 | 9.95 | 107 | 61398 | 69211 | 63358306 |
| Aphthous ulcer | 10.00 | 9.95 | 33 | 61472 | 13905 | 63413612 |
| Leukaemia | 9.96 | 9.95 | 16 | 61489 | 4192 | 63423325 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Interstitial lung disease | 135.80 | 10.76 | 249 | 37571 | 65033 | 34854078 |
| Hepatic function abnormal | 123.85 | 10.76 | 193 | 37627 | 44170 | 34874941 |
| Coombs positive haemolytic anaemia | 113.94 | 10.76 | 42 | 37778 | 930 | 34918181 |
| Needle fatigue | 99.35 | 10.76 | 37 | 37783 | 844 | 34918267 |
| Toxicity to various agents | 96.78 | 10.76 | 48 | 37772 | 200314 | 34718797 |
| Relapsing-remitting multiple sclerosis | 93.04 | 10.76 | 37 | 37783 | 1013 | 34918098 |
| Gait spastic | 91.50 | 10.76 | 37 | 37783 | 1059 | 34918052 |
| Lymphadenitis | 87.16 | 10.76 | 43 | 37777 | 1985 | 34917126 |
| Hypertonic bladder | 84.53 | 10.76 | 41 | 37779 | 1823 | 34917288 |
| Completed suicide | 75.12 | 10.76 | 9 | 37811 | 98159 | 34820952 |
| Drug abuse | 69.05 | 10.76 | 12 | 37808 | 99084 | 34820027 |
| Death | 67.62 | 10.76 | 214 | 37606 | 397835 | 34521276 |
| Monoparesis | 64.70 | 10.76 | 37 | 37783 | 2309 | 34916802 |
| Oesophageal pain | 61.85 | 10.76 | 26 | 37794 | 823 | 34918288 |
| Cerebral infarction | 58.63 | 10.76 | 106 | 37714 | 27349 | 34891762 |
| Parathyroid gland enlargement | 56.90 | 10.76 | 16 | 37804 | 141 | 34918970 |
| Upper respiratory fungal infection | 55.36 | 10.76 | 16 | 37804 | 157 | 34918954 |
| Product dose omission issue | 52.90 | 10.76 | 32 | 37788 | 119679 | 34799432 |
| Tetanus | 49.39 | 10.76 | 12 | 37808 | 55 | 34919056 |
| Off label use | 48.96 | 10.76 | 261 | 37559 | 419263 | 34499848 |
| Hypoparathyroidism secondary | 48.03 | 10.76 | 14 | 37806 | 142 | 34918969 |
| Movement disorder | 46.95 | 10.76 | 62 | 37758 | 12186 | 34906925 |
| Forced expiratory volume | 46.39 | 10.76 | 13 | 37807 | 113 | 34918998 |
| Hepatic cancer | 44.98 | 10.76 | 50 | 37770 | 8225 | 34910886 |
| Anorectal discomfort | 43.77 | 10.76 | 27 | 37793 | 1937 | 34917174 |
| Muscle spasticity | 43.60 | 10.76 | 42 | 37778 | 5846 | 34913265 |
| Drug ineffective | 42.46 | 10.76 | 305 | 37515 | 456446 | 34462665 |
| Gastrointestinal motility disorder | 41.64 | 10.76 | 29 | 37791 | 2555 | 34916556 |
| Gastrooesophageal reflux disease | 41.57 | 10.76 | 112 | 37708 | 37812 | 34881299 |
| Haemolysis | 40.75 | 10.76 | 47 | 37773 | 8047 | 34911064 |
| Central nervous system lesion | 40.31 | 10.76 | 42 | 37778 | 6421 | 34912690 |
| Micturition urgency | 39.97 | 10.76 | 42 | 37778 | 6483 | 34912628 |
| Nipple inflammation | 39.95 | 10.76 | 10 | 37810 | 53 | 34919058 |
| Migraine | 39.26 | 10.76 | 69 | 37751 | 17409 | 34901702 |
| Clumsiness | 39.08 | 10.76 | 24 | 37796 | 1708 | 34917403 |
| Hypergastrinaemia | 37.58 | 10.76 | 10 | 37810 | 70 | 34919041 |
| Asthma | 35.30 | 10.76 | 114 | 37706 | 42542 | 34876569 |
| Nocturia | 35.06 | 10.76 | 49 | 37771 | 10161 | 34908950 |
| Mycobacterium test positive | 34.38 | 10.76 | 14 | 37806 | 408 | 34918703 |
| Lung diffusion test decreased | 32.26 | 10.76 | 15 | 37805 | 606 | 34918505 |
| Ocular discomfort | 32.19 | 10.76 | 23 | 37797 | 2111 | 34917000 |
| Nerve degeneration | 32.01 | 10.76 | 11 | 37809 | 197 | 34918914 |
| Liver disorder | 31.79 | 10.76 | 93 | 37727 | 32904 | 34886207 |
| Occupational dermatitis | 30.81 | 10.76 | 9 | 37811 | 92 | 34919019 |
| Erythema multiforme | 30.44 | 10.76 | 42 | 37778 | 8607 | 34910504 |
| Treatment failure | 29.71 | 10.76 | 7 | 37813 | 46690 | 34872421 |
| Bronchopulmonary aspergillosis allergic | 29.29 | 10.76 | 16 | 37804 | 913 | 34918198 |
| Chronic kidney disease | 28.72 | 10.76 | 104 | 37716 | 41106 | 34878005 |
| Hypomagnesaemia | 28.58 | 10.76 | 69 | 37751 | 21782 | 34897329 |
| Hospitalisation | 28.38 | 10.76 | 13 | 37807 | 56889 | 34862222 |
| Tetany | 28.20 | 10.76 | 15 | 37805 | 811 | 34918300 |
| Nipple disorder | 28.07 | 10.76 | 10 | 37810 | 200 | 34918911 |
| Bronchial disorder | 28.04 | 10.76 | 18 | 37802 | 1385 | 34917726 |
| COVID-19 | 27.49 | 10.76 | 26 | 37794 | 77524 | 34841587 |
| Drug eruption | 27.28 | 10.76 | 64 | 37756 | 19834 | 34899277 |
| Tendon disorder | 26.13 | 10.76 | 23 | 37797 | 2852 | 34916259 |
| Decreased appetite | 26.10 | 10.76 | 285 | 37535 | 166107 | 34753004 |
| Interstitial granulomatous dermatitis | 25.60 | 10.76 | 9 | 37811 | 173 | 34918938 |
| Hepatic encephalopathy | 25.56 | 10.76 | 52 | 37768 | 14633 | 34904478 |
| Lung disorder | 25.41 | 10.76 | 89 | 37731 | 34607 | 34884504 |
| Muscle strain | 25.08 | 10.76 | 26 | 37794 | 3950 | 34915161 |
| Intentional overdose | 25.06 | 10.76 | 8 | 37812 | 43666 | 34875445 |
| Renal cyst | 24.57 | 10.76 | 39 | 37781 | 9054 | 34910057 |
| Rhinitis | 24.16 | 10.76 | 32 | 37788 | 6306 | 34912805 |
| Ataxia | 24.05 | 10.76 | 49 | 37771 | 13804 | 34905307 |
| Product use in unapproved indication | 23.67 | 10.76 | 58 | 37762 | 117441 | 34801670 |
| Primary hypoparathyroidism | 23.64 | 10.76 | 6 | 37814 | 34 | 34919077 |
| Duodenal polyp | 23.47 | 10.76 | 9 | 37811 | 223 | 34918888 |
| Blood pressure increased | 23.17 | 10.76 | 169 | 37651 | 87933 | 34831178 |
| Enterocolitis haemorrhagic | 23.15 | 10.76 | 14 | 37806 | 969 | 34918142 |
| Nephrectomy | 23.12 | 10.76 | 13 | 37807 | 785 | 34918326 |
| Platelet count decreased | 23.07 | 10.76 | 214 | 37606 | 119503 | 34799608 |
| Chest discomfort | 22.84 | 10.76 | 118 | 37702 | 54412 | 34864699 |
| Gastric polyps | 22.71 | 10.76 | 15 | 37805 | 1211 | 34917900 |
| Occupational exposure to air contaminants | 22.65 | 10.76 | 8 | 37812 | 156 | 34918955 |
| Tubulointerstitial nephritis | 21.94 | 10.76 | 61 | 37759 | 20963 | 34898148 |
| Haemochromatosis | 21.84 | 10.76 | 14 | 37806 | 1074 | 34918037 |
| Infusion related reaction | 21.66 | 10.76 | 114 | 37706 | 52943 | 34866168 |
| IIIrd nerve paresis | 21.52 | 10.76 | 7 | 37813 | 105 | 34919006 |
| Disseminated intravascular coagulation | 21.50 | 10.76 | 62 | 37758 | 21754 | 34897357 |
| Carotid arteriosclerosis | 21.31 | 10.76 | 17 | 37803 | 1841 | 34917270 |
| Hypocalcaemia | 21.08 | 10.76 | 66 | 37754 | 24223 | 34894888 |
| Erectile dysfunction | 20.68 | 10.76 | 59 | 37761 | 20578 | 34898533 |
| Idiopathic pulmonary fibrosis | 20.33 | 10.76 | 22 | 37798 | 3512 | 34915599 |
| Hepatocellular carcinoma | 20.00 | 10.76 | 32 | 37788 | 7477 | 34911634 |
| Ear discomfort | 19.85 | 10.76 | 19 | 37801 | 2623 | 34916488 |
| Gastric adenoma | 19.66 | 10.76 | 4 | 37816 | 6 | 34919105 |
| Mycobacterial infection | 19.62 | 10.76 | 18 | 37802 | 2356 | 34916755 |
| Haemorrhagic cerebral infarction | 19.48 | 10.76 | 12 | 37808 | 859 | 34918252 |
| Pollakiuria | 19.47 | 10.76 | 56 | 37764 | 19618 | 34899493 |
| Nasopharyngitis | 19.43 | 10.76 | 136 | 37684 | 69832 | 34849279 |
| Anxiety | 19.28 | 10.76 | 178 | 37642 | 99250 | 34819861 |
| Gastric cancer | 19.23 | 10.76 | 29 | 37791 | 6440 | 34912671 |
| Fatigue | 19.21 | 10.76 | 284 | 37536 | 370369 | 34548742 |
| Dyslalia | 18.64 | 10.76 | 10 | 37810 | 550 | 34918561 |
| Bronchiectasis | 18.62 | 10.76 | 36 | 37784 | 9765 | 34909346 |
| Hypoaesthesia | 18.59 | 10.76 | 122 | 37698 | 61322 | 34857789 |
| Cardiac failure | 18.53 | 10.76 | 165 | 37655 | 91083 | 34828028 |
| Complex regional pain syndrome | 18.53 | 10.76 | 10 | 37810 | 557 | 34918554 |
| Eczema | 17.79 | 10.76 | 52 | 37768 | 18384 | 34900727 |
| Sneezing | 17.76 | 10.76 | 25 | 37795 | 5217 | 34913894 |
| Multiple sclerosis relapse | 17.74 | 10.76 | 42 | 37778 | 13091 | 34906020 |
| Polymyalgia rheumatica | 17.71 | 10.76 | 14 | 37806 | 1496 | 34917615 |
| Sitting disability | 17.42 | 10.76 | 7 | 37813 | 197 | 34918914 |
| Dysarthria | 17.24 | 10.76 | 79 | 37741 | 34703 | 34884408 |
| Benign prostatic hyperplasia | 17.09 | 10.76 | 44 | 37776 | 14451 | 34904660 |
| Bone density decreased | 16.67 | 10.76 | 15 | 37805 | 1914 | 34917197 |
| Device breakage | 16.27 | 10.76 | 16 | 37804 | 2284 | 34916827 |
| Delusion of replacement | 16.19 | 10.76 | 6 | 37814 | 135 | 34918976 |
| Hyperuricaemia | 15.84 | 10.76 | 30 | 37790 | 8013 | 34911098 |
| Metaplasia | 15.73 | 10.76 | 7 | 37813 | 255 | 34918856 |
| Thrombosis | 15.55 | 10.76 | 19 | 37801 | 50439 | 34868672 |
| Renal impairment | 15.31 | 10.76 | 163 | 37657 | 94350 | 34824761 |
| Hyperventilation | 15.24 | 10.76 | 17 | 37803 | 2807 | 34916304 |
| Sinus congestion | 15.08 | 10.76 | 24 | 37796 | 5581 | 34913530 |
| Abdominal rigidity | 14.68 | 10.76 | 12 | 37808 | 1345 | 34917766 |
| Sensory disturbance | 14.67 | 10.76 | 25 | 37795 | 6152 | 34912959 |
| Foetal exposure during pregnancy | 14.42 | 10.76 | 12 | 37808 | 38089 | 34881022 |
| Blood pressure diastolic decreased | 14.42 | 10.76 | 31 | 37789 | 9063 | 34910048 |
| Nephroangiosclerosis | 14.27 | 10.76 | 6 | 37814 | 190 | 34918921 |
| General physical health deterioration | 14.21 | 10.76 | 81 | 37739 | 128188 | 34790923 |
| Leukocyte adhesion deficiency type I | 14.15 | 10.76 | 4 | 37816 | 36 | 34919075 |
| Gastrointestinal polyp haemorrhage | 13.91 | 10.76 | 7 | 37813 | 337 | 34918774 |
| Erythema of eyelid | 13.83 | 10.76 | 10 | 37810 | 935 | 34918176 |
| Altered state of consciousness | 13.66 | 10.76 | 55 | 37765 | 22838 | 34896273 |
| Sedation | 13.66 | 10.76 | 3 | 37817 | 21003 | 34898108 |
| Pyomyositis | 13.58 | 10.76 | 6 | 37814 | 215 | 34918896 |
| Malaise | 13.55 | 10.76 | 279 | 37541 | 185546 | 34733565 |
| Occupational exposure to product | 13.34 | 10.76 | 7 | 37813 | 368 | 34918743 |
| Thalamus haemorrhage | 13.28 | 10.76 | 10 | 37810 | 995 | 34918116 |
| Asthma-chronic obstructive pulmonary disease overlap syndrome | 13.13 | 10.76 | 11 | 37809 | 1276 | 34917835 |
| Cholangitis | 13.08 | 10.76 | 29 | 37791 | 8660 | 34910451 |
| Renal neoplasm | 13.06 | 10.76 | 11 | 37809 | 1286 | 34917825 |
| Dermatitis allergic | 12.86 | 10.76 | 25 | 37795 | 6805 | 34912306 |
| Injection site pain | 12.76 | 10.76 | 14 | 37806 | 38991 | 34880120 |
| Oxygen consumption increased | 12.56 | 10.76 | 11 | 37809 | 1355 | 34917756 |
| Neuropathy peripheral | 12.53 | 10.76 | 47 | 37773 | 83216 | 34835895 |
| Dizziness | 12.48 | 10.76 | 317 | 37503 | 218204 | 34700907 |
| Balance disorder | 12.46 | 10.76 | 81 | 37739 | 40573 | 34878538 |
| Obstruction | 12.38 | 10.76 | 15 | 37805 | 2704 | 34916407 |
| Premature baby | 12.37 | 10.76 | 3 | 37817 | 19630 | 34899481 |
| Drug intolerance | 12.31 | 10.76 | 29 | 37791 | 59541 | 34859570 |
| Heart rate decreased | 12.13 | 10.76 | 67 | 37753 | 31678 | 34887433 |
| Dermatitis acneiform | 12.08 | 10.76 | 23 | 37797 | 6166 | 34912945 |
| Hepatic enzyme increased | 12.06 | 10.76 | 78 | 37742 | 39002 | 34880109 |
| Bronchiolitis | 12.05 | 10.76 | 16 | 37804 | 3160 | 34915951 |
| Electrocardiogram abnormal | 11.87 | 10.76 | 29 | 37791 | 9218 | 34909893 |
| Angina pectoris | 11.86 | 10.76 | 66 | 37754 | 31297 | 34887814 |
| Constipation | 11.80 | 10.76 | 211 | 37609 | 136771 | 34782340 |
| Renal mass | 11.75 | 10.76 | 12 | 37808 | 1792 | 34917319 |
| Hypotension | 11.73 | 10.76 | 169 | 37651 | 221480 | 34697631 |
| Disease progression | 11.57 | 10.76 | 69 | 37751 | 108008 | 34811103 |
| Eye movement disorder | 11.56 | 10.76 | 18 | 37802 | 4109 | 34915002 |
| Folliculitis | 11.54 | 10.76 | 19 | 37801 | 4547 | 34914564 |
| Allergy to vaccine | 11.53 | 10.76 | 3 | 37817 | 19 | 34919092 |
| Abdominal discomfort | 11.53 | 10.76 | 107 | 37713 | 59728 | 34859383 |
| Blood immunoglobulin E increased | 11.52 | 10.76 | 14 | 37806 | 2532 | 34916579 |
| Glaucoma | 11.47 | 10.76 | 24 | 37796 | 6888 | 34912223 |
| Neck injury | 11.35 | 10.76 | 10 | 37810 | 1241 | 34917870 |
| Intentional product misuse | 11.30 | 10.76 | 20 | 37800 | 45591 | 34873520 |
| Pulmonary function test abnormal | 11.24 | 10.76 | 14 | 37806 | 2596 | 34916515 |
| Tachypnoea | 11.19 | 10.76 | 3 | 37817 | 18349 | 34900762 |
| Cerebral hypoperfusion | 11.16 | 10.76 | 7 | 37813 | 517 | 34918594 |
| Neurotoxicity | 10.88 | 10.76 | 3 | 37817 | 18007 | 34901104 |
| Enteritis infectious | 10.80 | 10.76 | 10 | 37810 | 1324 | 34917787 |
| Fibrin degradation products increased | 10.80 | 10.76 | 5 | 37815 | 200 | 34918911 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Interstitial lung disease | 182.41 | 9.71 | 384 | 84809 | 112216 | 79546979 |
| Hepatic function abnormal | 178.09 | 9.71 | 297 | 84896 | 72810 | 79586385 |
| Completed suicide | 169.99 | 9.71 | 29 | 85164 | 245738 | 79413457 |
| Toxicity to various agents | 164.47 | 9.71 | 126 | 85067 | 421414 | 79237781 |
| Obstructive airways disorder | 132.85 | 9.71 | 166 | 85027 | 31293 | 79627902 |
| Vital capacity decreased | 124.26 | 9.71 | 53 | 85140 | 1763 | 79657432 |
| Reversible airways obstruction | 121.35 | 9.71 | 55 | 85138 | 2121 | 79657074 |
| Drug abuse | 119.79 | 9.71 | 16 | 85177 | 162675 | 79496520 |
| Hypertonic bladder | 113.25 | 9.71 | 65 | 85128 | 4136 | 79655059 |
| Coombs positive haemolytic anaemia | 108.29 | 9.71 | 42 | 85151 | 1088 | 79658107 |
| Eosinophil count increased | 105.78 | 9.71 | 110 | 85083 | 16995 | 79642200 |
| Synovitis | 97.37 | 9.71 | 21 | 85172 | 150713 | 79508482 |
| Sputum culture positive | 95.29 | 9.71 | 56 | 85137 | 3725 | 79655470 |
| Maternal exposure during pregnancy | 94.60 | 9.71 | 16 | 85177 | 136522 | 79522673 |
| Needle fatigue | 91.70 | 9.71 | 35 | 85158 | 867 | 79658328 |
| Bronchial secretion retention | 91.05 | 9.71 | 56 | 85137 | 4048 | 79655147 |
| Full blood count abnormal | 90.06 | 9.71 | 158 | 85035 | 40316 | 79618879 |
| Pemphigus | 89.32 | 9.71 | 4 | 85189 | 99578 | 79559617 |
| Death | 88.34 | 9.71 | 310 | 84883 | 566204 | 79092991 |
| Loss of employment | 86.13 | 9.71 | 46 | 85147 | 2541 | 79656654 |
| Hypomagnesaemia | 84.21 | 9.71 | 167 | 85026 | 46744 | 79612451 |
| Gastrooesophageal reflux disease | 84.20 | 9.71 | 274 | 84919 | 103972 | 79555223 |
| Gait spastic | 82.12 | 9.71 | 35 | 85158 | 1162 | 79658033 |
| Cerebral infarction | 78.87 | 9.71 | 160 | 85033 | 45516 | 79613679 |
| Multiple allergies | 77.09 | 9.71 | 74 | 85119 | 10386 | 79648809 |
| Relapsing-remitting multiple sclerosis | 74.12 | 9.71 | 35 | 85158 | 1484 | 79657711 |
| Product dose omission issue | 69.33 | 9.71 | 98 | 85095 | 247439 | 79411756 |
| Pericarditis | 68.38 | 9.71 | 14 | 85179 | 104222 | 79554973 |
| Eosinophilic bronchitis | 68.24 | 9.71 | 24 | 85169 | 468 | 79658727 |
| Hand deformity | 64.08 | 9.71 | 16 | 85177 | 103903 | 79555292 |
| Lung diffusion test decreased | 63.36 | 9.71 | 30 | 85163 | 1280 | 79657915 |
| Anti-cyclic citrullinated peptide antibody positive | 61.60 | 9.71 | 8 | 85185 | 83135 | 79576060 |
| Treatment failure | 61.37 | 9.71 | 55 | 85138 | 170431 | 79488764 |
| Lymphadenitis | 61.32 | 9.71 | 46 | 85147 | 4609 | 79654586 |
| Gastric polyps | 58.40 | 9.71 | 41 | 85152 | 3706 | 79655489 |
| Nasal disorder | 58.18 | 9.71 | 41 | 85152 | 3728 | 79655467 |
| Platelet count decreased | 57.81 | 9.71 | 381 | 84812 | 194283 | 79464912 |
| Upper-airway cough syndrome | 56.37 | 9.71 | 66 | 85127 | 11627 | 79647568 |
| Liver disorder | 56.36 | 9.71 | 188 | 85005 | 72229 | 79586966 |
| Drug eruption | 55.67 | 9.71 | 136 | 85057 | 43799 | 79615396 |
| Duodenal ulcer perforation | 55.27 | 9.71 | 4 | 85189 | 66207 | 79592988 |
| Glossodynia | 54.59 | 9.71 | 21 | 85172 | 103316 | 79555879 |
| Erythema multiforme | 54.49 | 9.71 | 80 | 85113 | 17571 | 79641624 |
| Asthma | 53.36 | 9.71 | 285 | 84908 | 134810 | 79524385 |
| Tonsillar disorder | 52.22 | 9.71 | 26 | 85167 | 1240 | 79657955 |
| Wound | 51.57 | 9.71 | 30 | 85163 | 116149 | 79543046 |
| Alopecia | 51.54 | 9.71 | 106 | 85087 | 231249 | 79427946 |
| Blood pressure increased | 51.31 | 9.71 | 394 | 84799 | 210966 | 79448229 |
| Pulmonary mass | 50.47 | 9.71 | 102 | 85091 | 28932 | 79630263 |
| Rheumatoid arthritis | 49.71 | 9.71 | 387 | 84806 | 208083 | 79451112 |
| Tetanus | 49.54 | 9.71 | 12 | 85181 | 55 | 79659140 |
| Monoparesis | 49.17 | 9.71 | 36 | 85157 | 3475 | 79655720 |
| Enterocolitis haemorrhagic | 48.83 | 9.71 | 30 | 85163 | 2164 | 79657031 |
| Parathyroid gland enlargement | 46.77 | 9.71 | 14 | 85179 | 159 | 79659036 |
| Nicotine dependence | 46.59 | 9.71 | 22 | 85171 | 933 | 79658262 |
| Rheumatoid factor positive | 46.21 | 9.71 | 5 | 85188 | 59834 | 79599361 |
| Sputum purulent | 44.95 | 9.71 | 24 | 85169 | 1325 | 79657870 |
| Systemic lupus erythematosus | 44.91 | 9.71 | 38 | 85155 | 121111 | 79538084 |
| Cestode infection | 44.13 | 9.71 | 15 | 85178 | 263 | 79658932 |
| Forced expiratory volume | 43.74 | 9.71 | 12 | 85181 | 97 | 79659098 |
| Oral discomfort | 43.61 | 9.71 | 53 | 85140 | 9707 | 79649488 |
| Hypoparathyroidism secondary | 42.96 | 9.71 | 14 | 85179 | 214 | 79658981 |
| Colitis microscopic | 42.57 | 9.71 | 55 | 85138 | 10713 | 79648482 |
| Cardiac failure | 41.17 | 9.71 | 295 | 84898 | 154547 | 79504648 |
| Polymyalgia rheumatica | 41.04 | 9.71 | 36 | 85157 | 4501 | 79654694 |
| Hypocalcaemia | 40.99 | 9.71 | 132 | 85061 | 49792 | 79609403 |
| Nipple inflammation | 40.56 | 9.71 | 10 | 85183 | 50 | 79659145 |
| Tubulointerstitial nephritis | 39.85 | 9.71 | 110 | 85083 | 38125 | 79621070 |
| Lichen sclerosus | 39.78 | 9.71 | 20 | 85173 | 974 | 79658221 |
| Off label use | 39.27 | 9.71 | 708 | 84485 | 906507 | 78752688 |
| Hepatic cancer | 38.87 | 9.71 | 52 | 85141 | 10477 | 79648718 |
| Upper respiratory fungal infection | 36.90 | 9.71 | 14 | 85179 | 341 | 79658854 |
| Discomfort | 36.89 | 9.71 | 48 | 85145 | 125569 | 79533626 |
| Hypergastrinaemia | 36.21 | 9.71 | 12 | 85181 | 194 | 79659001 |
| Helicobacter infection | 35.45 | 9.71 | 15 | 85178 | 69689 | 79589506 |
| Oesophageal pain | 34.85 | 9.71 | 32 | 85161 | 4247 | 79654948 |
| Hiatus hernia | 34.83 | 9.71 | 77 | 85116 | 23235 | 79635960 |
| Premenstrual syndrome | 33.77 | 9.71 | 15 | 85178 | 551 | 79658644 |
| Anorectal discomfort | 33.36 | 9.71 | 29 | 85164 | 3582 | 79655613 |
| Clumsiness | 32.77 | 9.71 | 27 | 85166 | 3100 | 79656095 |
| Overdose | 32.67 | 9.71 | 95 | 85098 | 184111 | 79475084 |
| Decreased appetite | 32.47 | 9.71 | 530 | 84663 | 341888 | 79317307 |
| Magnesium deficiency | 32.37 | 9.71 | 15 | 85178 | 609 | 79658586 |
| Cholecystitis chronic | 32.18 | 9.71 | 46 | 85147 | 9860 | 79649335 |
| Hepatic encephalopathy | 31.89 | 9.71 | 76 | 85117 | 24090 | 79635105 |
| Intentional overdose | 31.62 | 9.71 | 40 | 85153 | 105920 | 79553275 |
| Blood pressure diastolic decreased | 31.55 | 9.71 | 87 | 85106 | 30129 | 79629066 |
| Exposure during pregnancy | 31.42 | 9.71 | 37 | 85156 | 101095 | 79558100 |
| Occupational dermatitis | 31.17 | 9.71 | 10 | 85183 | 145 | 79659050 |
| Movement disorder | 31.00 | 9.71 | 81 | 85112 | 27178 | 79632017 |
| Hepatocellular carcinoma | 30.95 | 9.71 | 43 | 85150 | 8978 | 79650217 |
| Renal cyst | 30.83 | 9.71 | 56 | 85137 | 14676 | 79644519 |
| Fatigue | 30.69 | 9.71 | 758 | 84435 | 928969 | 78730226 |
| Cough | 30.55 | 9.71 | 556 | 84637 | 366233 | 79292962 |
| Malaise | 30.43 | 9.71 | 711 | 84482 | 489158 | 79170037 |
| Mycobacterium test positive | 30.38 | 9.71 | 13 | 85180 | 436 | 79658759 |
| Sedation | 30.09 | 9.71 | 9 | 85184 | 51886 | 79607309 |
| Secondary immunodeficiency | 29.93 | 9.71 | 26 | 85167 | 3208 | 79655987 |
| Nocturia | 29.90 | 9.71 | 53 | 85140 | 13628 | 79645567 |
| Haemolysis | 29.78 | 9.71 | 51 | 85142 | 12761 | 79646434 |
| Renal impairment | 29.72 | 9.71 | 278 | 84915 | 157505 | 79501690 |
| Product use in unapproved indication | 29.65 | 9.71 | 152 | 85041 | 250207 | 79408988 |
| Neutrophil count decreased | 29.15 | 9.71 | 186 | 85007 | 93773 | 79565422 |
| Gastric disorder | 28.96 | 9.71 | 97 | 85096 | 37336 | 79621859 |
| C-reactive protein abnormal | 28.76 | 9.71 | 8 | 85185 | 48359 | 79610836 |
| Gastrointestinal motility disorder | 28.59 | 9.71 | 34 | 85159 | 6088 | 79653107 |
| Nerve degeneration | 28.54 | 9.71 | 11 | 85182 | 280 | 79658915 |
| Intentional product misuse | 28.32 | 9.71 | 36 | 85157 | 95129 | 79564066 |
| Nipple disorder | 28.01 | 9.71 | 10 | 85183 | 204 | 79658991 |
| Pneumothorax spontaneous | 27.65 | 9.71 | 18 | 85175 | 1436 | 79657759 |
| Hepatic steatosis | 27.62 | 9.71 | 96 | 85097 | 37642 | 79621553 |
| Respiratory tract infection | 27.49 | 9.71 | 114 | 85079 | 48575 | 79610620 |
| Erectile dysfunction | 27.27 | 9.71 | 53 | 85140 | 14611 | 79644584 |
| Lip pruritus | 26.99 | 9.71 | 15 | 85178 | 897 | 79658298 |
| Polyp | 26.86 | 9.71 | 38 | 85155 | 8069 | 79651126 |
| General physical health deterioration | 26.78 | 9.71 | 178 | 85015 | 275060 | 79384135 |
| Blood pressure fluctuation | 26.73 | 9.71 | 142 | 85051 | 67003 | 79592192 |
| Mucosal inflammation | 26.45 | 9.71 | 25 | 85168 | 75555 | 79583640 |
| Pulmonary function test abnormal | 26.25 | 9.71 | 27 | 85166 | 4117 | 79655078 |
| Malignant polyp | 25.91 | 9.71 | 9 | 85184 | 169 | 79659026 |
| Polymenorrhoea | 25.67 | 9.71 | 15 | 85178 | 987 | 79658208 |
| Hypokalaemia | 25.26 | 9.71 | 250 | 84943 | 143790 | 79515405 |
| Lip infection | 24.84 | 9.71 | 9 | 85184 | 192 | 79659003 |
| Hypereosinophilic syndrome | 24.83 | 9.71 | 12 | 85181 | 536 | 79658659 |
| Idiopathic pulmonary fibrosis | 24.03 | 9.71 | 26 | 85167 | 4202 | 79654993 |
| Sputum culture | 23.81 | 9.71 | 9 | 85184 | 217 | 79658978 |
| Tubulointerstitial nephritis and uveitis syndrome | 23.66 | 9.71 | 10 | 85183 | 325 | 79658870 |
| Abdominal distension | 23.63 | 9.71 | 213 | 84980 | 119437 | 79539758 |
| Primary hypoparathyroidism | 23.28 | 9.71 | 6 | 85187 | 37 | 79659158 |
| Interstitial granulomatous dermatitis | 23.21 | 9.71 | 9 | 85184 | 233 | 79658962 |
| Hepatotoxicity | 23.15 | 9.71 | 13 | 85180 | 51339 | 79607856 |
| Menstruation delayed | 23.15 | 9.71 | 16 | 85177 | 1410 | 79657785 |
| Gastric cancer | 22.98 | 9.71 | 40 | 85153 | 10139 | 79649056 |
| Occupational exposure to air contaminants | 22.75 | 9.71 | 8 | 85185 | 156 | 79659039 |
| Micturition urgency | 22.67 | 9.71 | 45 | 85148 | 12596 | 79646599 |
| Abdominal pain upper | 22.54 | 9.71 | 350 | 84843 | 223469 | 79435726 |
| Gastrointestinal polyp haemorrhage | 22.50 | 9.71 | 11 | 85182 | 504 | 79658691 |
| Chronic kidney disease | 22.43 | 9.71 | 134 | 85059 | 66020 | 79593175 |
| Heart rate increased | 22.37 | 9.71 | 212 | 84981 | 120512 | 79538683 |
| Blood pressure systolic increased | 22.27 | 9.71 | 135 | 85058 | 66851 | 79592344 |
| Adenocarcinoma | 22.26 | 9.71 | 24 | 85169 | 3862 | 79655333 |
| Dyslalia | 22.19 | 9.71 | 14 | 85179 | 1058 | 79658137 |
| Enteritis infectious | 21.60 | 9.71 | 22 | 85171 | 3316 | 79655879 |
| Upper respiratory tract inflammation | 21.52 | 9.71 | 24 | 85169 | 4011 | 79655184 |
| Hypotension | 21.45 | 9.71 | 336 | 84857 | 439981 | 79219214 |
| Barotrauma | 21.20 | 9.71 | 8 | 85185 | 192 | 79659003 |
| Iron deficiency anaemia | 21.18 | 9.71 | 68 | 85125 | 25604 | 79633591 |
| Folliculitis | 20.97 | 9.71 | 17 | 85176 | 55363 | 79603832 |
| Biliary dyskinesia | 20.66 | 9.71 | 19 | 85174 | 2526 | 79656669 |
| Neutropenia | 20.64 | 9.71 | 202 | 84991 | 287508 | 79371687 |
| Drug intolerance | 20.42 | 9.71 | 182 | 85011 | 263937 | 79395258 |
| Duodenal polyp | 20.30 | 9.71 | 9 | 85184 | 329 | 79658866 |
| Disseminated intravascular coagulation | 20.29 | 9.71 | 84 | 85109 | 35758 | 79623437 |
| Limb mass | 20.22 | 9.71 | 22 | 85171 | 3577 | 79655618 |
| Lung disorder | 19.98 | 9.71 | 151 | 85042 | 80406 | 79578789 |
| Adverse event | 19.83 | 9.71 | 21 | 85172 | 60193 | 79599002 |
| Central nervous system lesion | 19.80 | 9.71 | 44 | 85149 | 13324 | 79645871 |
| Hypertension | 19.78 | 9.71 | 478 | 84715 | 330514 | 79328681 |
| Respiratory depression | 19.66 | 9.71 | 3 | 85190 | 27627 | 79631568 |
| Muscle strain | 19.59 | 9.71 | 36 | 85157 | 9519 | 79649676 |
| Suicide attempt | 19.31 | 9.71 | 37 | 85156 | 82895 | 79576300 |
| Haemochromatosis | 19.26 | 9.71 | 14 | 85179 | 1336 | 79657859 |
| Therapy cessation | 19.23 | 9.71 | 8 | 85185 | 37554 | 79621641 |
| Aortic dissection | 19.19 | 9.71 | 23 | 85170 | 4152 | 79655043 |
| Uveitis | 19.12 | 9.71 | 50 | 85143 | 16780 | 79642415 |
| Disease progression | 19.06 | 9.71 | 117 | 85076 | 184245 | 79474950 |
| Intra-abdominal fluid collection | 18.90 | 9.71 | 20 | 85173 | 3152 | 79656043 |
| Retinal toxicity | 18.71 | 9.71 | 14 | 85179 | 1397 | 79657798 |
| Therapy non-responder | 18.33 | 9.71 | 45 | 85148 | 92260 | 79566935 |
| Macule | 18.25 | 9.71 | 19 | 85174 | 2938 | 79656257 |
| Neurotoxicity | 18.21 | 9.71 | 6 | 85187 | 32512 | 79626683 |
| Radioallergosorbent test positive | 18.16 | 9.71 | 5 | 85188 | 41 | 79659154 |
| Clitoris abscess | 18.10 | 9.71 | 4 | 85189 | 11 | 79659184 |
| Benign prostatic hyperplasia | 18.08 | 9.71 | 39 | 85154 | 11573 | 79647622 |
| Irritable bowel syndrome | 18.05 | 9.71 | 24 | 85169 | 62217 | 79596978 |
| Product prescribing error | 17.94 | 9.71 | 13 | 85180 | 44800 | 79614395 |
| Somnolence | 17.90 | 9.71 | 166 | 85027 | 238815 | 79420380 |
| Hospitalisation | 17.89 | 9.71 | 47 | 85146 | 94189 | 79565006 |
| Spinal compression fracture | 17.88 | 9.71 | 49 | 85144 | 16909 | 79642286 |
| Multiple organ dysfunction syndrome | 17.87 | 9.71 | 67 | 85126 | 120179 | 79539016 |
| Rhinitis | 17.87 | 9.71 | 45 | 85148 | 14762 | 79644433 |
| Unresponsive to stimuli | 17.77 | 9.71 | 20 | 85173 | 55768 | 79603427 |
| IIIrd nerve paresis | 17.71 | 9.71 | 7 | 85186 | 191 | 79659004 |
| Bronchopulmonary aspergillosis allergic | 17.70 | 9.71 | 19 | 85174 | 3042 | 79656153 |
| Fall | 17.69 | 9.71 | 662 | 84531 | 486967 | 79172228 |
| Poisoning | 17.41 | 9.71 | 3 | 85190 | 25269 | 79633926 |
| Product use issue | 17.37 | 9.71 | 142 | 85051 | 209680 | 79449515 |
| Oesophageal varices haemorrhage | 17.32 | 9.71 | 22 | 85171 | 4214 | 79654981 |
| Bronchial disorder | 17.20 | 9.71 | 17 | 85176 | 2472 | 79656723 |
| Condition aggravated | 17.17 | 9.71 | 406 | 84787 | 500718 | 79158477 |
| Device issue | 17.05 | 9.71 | 4 | 85189 | 27104 | 79632091 |
| Cardiac failure chronic | 16.89 | 9.71 | 37 | 85156 | 11098 | 79648097 |
| Knee arthroplasty | 16.72 | 9.71 | 13 | 85180 | 43235 | 79615960 |
| Thrombocytopenia | 16.69 | 9.71 | 192 | 85001 | 265067 | 79394128 |
| Hyperuricaemia | 16.54 | 9.71 | 38 | 85155 | 11761 | 79647434 |
| Neutrophilia | 16.35 | 9.71 | 30 | 85163 | 7921 | 79651274 |
| Posterior reversible encephalopathy syndrome | 16.29 | 9.71 | 4 | 85189 | 26277 | 79632918 |
| Multiple fractures | 16.15 | 9.71 | 30 | 85163 | 7996 | 79651199 |
| Acute kidney injury | 16.12 | 9.71 | 427 | 84766 | 518977 | 79140218 |
| Body temperature fluctuation | 15.93 | 9.71 | 20 | 85173 | 3787 | 79655408 |
| Thalamus haemorrhage | 15.84 | 9.71 | 14 | 85179 | 1768 | 79657427 |
| Injection site pain | 15.83 | 9.71 | 78 | 85115 | 129760 | 79529435 |
| Tachycardia | 15.79 | 9.71 | 118 | 85075 | 177650 | 79481545 |
| Premature delivery | 15.70 | 9.71 | 3 | 85190 | 23464 | 79635731 |
| Blister | 15.61 | 9.71 | 70 | 85123 | 119406 | 79539789 |
| Rubella | 15.31 | 9.71 | 6 | 85187 | 160 | 79659035 |
| Dysarthria | 15.25 | 9.71 | 124 | 85069 | 67498 | 79591697 |
| Blood pressure decreased | 15.24 | 9.71 | 168 | 85025 | 99298 | 79559897 |
| Delusion of replacement | 15.20 | 9.71 | 6 | 85187 | 163 | 79659032 |
| Balance disorder | 15.16 | 9.71 | 167 | 85026 | 98690 | 79560505 |
| Prescribed overdose | 15.15 | 9.71 | 11 | 85182 | 37872 | 79621323 |
| Peripheral swelling | 15.13 | 9.71 | 200 | 84993 | 269417 | 79389778 |
| Chest discomfort | 15.10 | 9.71 | 219 | 84974 | 137825 | 79521370 |
| Red cell distribution width increased | 15.04 | 9.71 | 43 | 85150 | 15199 | 79643996 |
| Intentional product use issue | 14.97 | 9.71 | 98 | 85095 | 152014 | 79507181 |
| Somnambulism | 14.94 | 9.71 | 24 | 85169 | 5697 | 79653498 |
| Injection site swelling | 14.90 | 9.71 | 17 | 85176 | 47115 | 79612080 |
| Pneumonia bacterial | 14.87 | 9.71 | 50 | 85143 | 19281 | 79639914 |
| Injection site erythema | 14.84 | 9.71 | 39 | 85154 | 78158 | 79581037 |
| Hip arthroplasty | 14.80 | 9.71 | 10 | 85183 | 35746 | 79623449 |
| Sleep disorder due to a general medical condition | 14.80 | 9.71 | 41 | 85152 | 14236 | 79644959 |
| Sleep attacks | 14.68 | 9.71 | 6 | 85187 | 179 | 79659016 |
| Mental status changes | 14.62 | 9.71 | 31 | 85162 | 66928 | 79592267 |
| No adverse event | 14.61 | 9.71 | 11 | 85182 | 37181 | 79622014 |
| Cholangitis | 14.56 | 9.71 | 38 | 85155 | 12738 | 79646457 |
| Carotid arteriosclerosis | 14.51 | 9.71 | 16 | 85177 | 2640 | 79656555 |
| Productive cough | 14.37 | 9.71 | 151 | 85042 | 88180 | 79571015 |
| COVID-19 | 14.32 | 9.71 | 104 | 85089 | 157570 | 79501625 |
| Coeliac artery occlusion | 14.24 | 9.71 | 3 | 85190 | 6 | 79659189 |
| Tetany | 14.16 | 9.71 | 16 | 85177 | 2712 | 79656483 |
| Constipation | 14.07 | 9.71 | 399 | 84794 | 282651 | 79376544 |
| Blood alkaline phosphatase increased | 13.96 | 9.71 | 116 | 85077 | 63548 | 79595647 |
| Hepatitis chronic active | 13.94 | 9.71 | 6 | 85187 | 204 | 79658991 |
| Neck injury | 13.91 | 9.71 | 16 | 85177 | 2765 | 79656430 |
| Haemorrhagic cerebral infarction | 13.91 | 9.71 | 12 | 85181 | 1467 | 79657728 |
| Gastric antral vascular ectasia | 13.82 | 9.71 | 10 | 85183 | 948 | 79658247 |
| Dermatitis acneiform | 13.81 | 9.71 | 32 | 85161 | 9961 | 79649234 |
| Drug ineffective | 13.80 | 9.71 | 982 | 84211 | 1079931 | 78579264 |
| Hypercholesterolaemia | 13.77 | 9.71 | 55 | 85138 | 23040 | 79636155 |
| Gallbladder injury | 13.76 | 9.71 | 11 | 85182 | 1210 | 79657985 |
| Inappropriate antidiuretic hormone secretion | 13.61 | 9.71 | 60 | 85133 | 26253 | 79632942 |
| Neutropenic sepsis | 13.48 | 9.71 | 6 | 85187 | 27058 | 79632137 |
| Renal disorder | 13.45 | 9.71 | 84 | 85109 | 42021 | 79617174 |
| Erosive oesophagitis | 13.45 | 9.71 | 16 | 85177 | 2866 | 79656329 |
| Injection site reaction | 13.14 | 9.71 | 24 | 85169 | 54761 | 79604434 |
| Renal mass | 13.11 | 9.71 | 17 | 85176 | 3323 | 79655872 |
| Sitting disability | 13.05 | 9.71 | 7 | 85186 | 390 | 79658805 |
| Red blood cell sedimentation rate increased | 13.03 | 9.71 | 18 | 85175 | 45924 | 79613271 |
| Nasopharyngitis | 12.92 | 9.71 | 359 | 84834 | 253522 | 79405673 |
| Concomitant disease aggravated | 12.85 | 9.71 | 37 | 85156 | 13130 | 79646065 |
| Lower limb fracture | 12.82 | 9.71 | 54 | 85139 | 23161 | 79636034 |
| Blood gastrin increased | 12.73 | 9.71 | 4 | 85189 | 54 | 79659141 |
| Gamma-glutamyltransferase increased | 12.73 | 9.71 | 101 | 85092 | 54579 | 79604616 |
| Accidental exposure to product | 12.65 | 9.71 | 9 | 85184 | 31313 | 79627882 |
| Device dislocation | 12.56 | 9.71 | 6 | 85187 | 25964 | 79633231 |
| Oral discharge | 12.54 | 9.71 | 6 | 85187 | 262 | 79658933 |
| Liver iron concentration abnormal | 12.47 | 9.71 | 4 | 85189 | 58 | 79659137 |
| Colon cancer | 12.47 | 9.71 | 39 | 85154 | 14484 | 79644711 |
| Medication error | 12.45 | 9.71 | 35 | 85158 | 68607 | 79590588 |
| Neuropathy peripheral | 12.45 | 9.71 | 94 | 85099 | 141211 | 79517984 |
| Ear discomfort | 12.43 | 9.71 | 28 | 85165 | 8555 | 79650640 |
| Pneumonia | 12.39 | 9.71 | 841 | 84352 | 659405 | 78999790 |
| Gallbladder disorder | 12.29 | 9.71 | 47 | 85146 | 19293 | 79639902 |
| Intervertebral disc degeneration | 12.29 | 9.71 | 41 | 85152 | 15744 | 79643451 |
| Infection | 12.24 | 9.71 | 183 | 85010 | 241529 | 79417666 |
| Stress at work | 12.19 | 9.71 | 10 | 85183 | 1141 | 79658054 |
| Coronary artery disease | 12.14 | 9.71 | 115 | 85078 | 65359 | 79593836 |
| Pancreatic neuroendocrine tumour | 11.97 | 9.71 | 8 | 85185 | 667 | 79658528 |
| Forced expiratory volume decreased | 11.89 | 9.71 | 26 | 85167 | 7788 | 79651407 |
| Mycobacterial infection | 11.87 | 9.71 | 17 | 85176 | 3651 | 79655544 |
| Acute myocardial infarction | 11.75 | 9.71 | 130 | 85063 | 76906 | 79582289 |
| Accidental overdose | 11.74 | 9.71 | 15 | 85178 | 39566 | 79619629 |
| Arthralgia | 11.74 | 9.71 | 734 | 84459 | 571069 | 79088126 |
| Occupational exposure to product | 11.71 | 9.71 | 8 | 85185 | 692 | 79658503 |
| Chorioretinal disorder | 11.70 | 9.71 | 5 | 85188 | 167 | 79659028 |
| Lower respiratory tract infection viral | 11.68 | 9.71 | 10 | 85183 | 1210 | 79657985 |
| Compression fracture | 11.59 | 9.71 | 23 | 85170 | 6437 | 79652758 |
| Blood albumin decreased | 11.58 | 9.71 | 54 | 85139 | 24189 | 79635006 |
| Postmenopausal haemorrhage | 11.47 | 9.71 | 11 | 85182 | 1541 | 79657654 |
| Therapy interrupted | 11.40 | 9.71 | 10 | 85183 | 31331 | 79627864 |
| Coma | 11.40 | 9.71 | 62 | 85131 | 100587 | 79558608 |
| Cytokine release syndrome | 11.36 | 9.71 | 13 | 85180 | 35985 | 79623210 |
| Respiratory failure | 11.35 | 9.71 | 131 | 85062 | 180780 | 79478415 |
| Myocardial infarction | 11.31 | 9.71 | 267 | 84926 | 183862 | 79475333 |
| Anticoagulation drug level decreased | 11.25 | 9.71 | 5 | 85188 | 184 | 79659011 |
| Arthropathy | 11.21 | 9.71 | 128 | 85065 | 176983 | 79482212 |
| Intramedullary rod insertion | 11.17 | 9.71 | 5 | 85188 | 187 | 79659008 |
| Dyspnoea exertional | 11.10 | 9.71 | 142 | 85051 | 86931 | 79572264 |
| Confusional state | 11.05 | 9.71 | 257 | 84936 | 317740 | 79341455 |
| Nephroangiosclerosis | 11.04 | 9.71 | 6 | 85187 | 343 | 79658852 |
| Cardiac arrest | 11.04 | 9.71 | 124 | 85069 | 171972 | 79487223 |
| Blood iron increased | 11.02 | 9.71 | 11 | 85182 | 1619 | 79657576 |
| Cataract | 10.97 | 9.71 | 108 | 85085 | 62012 | 79597183 |
| Helicobacter test positive | 10.88 | 9.71 | 10 | 85183 | 1328 | 79657867 |
| Vaccination site pain | 10.88 | 9.71 | 5 | 85188 | 199 | 79658996 |
| Abdominal mass | 10.84 | 9.71 | 16 | 85177 | 3529 | 79655666 |
| Metaplasia | 10.79 | 9.71 | 7 | 85186 | 555 | 79658640 |
| Aggression | 10.79 | 9.71 | 24 | 85169 | 50934 | 79608261 |
| Dermatitis contact | 10.77 | 9.71 | 31 | 85162 | 11002 | 79648193 |
| Tachypnoea | 10.76 | 9.71 | 11 | 85182 | 32052 | 79627143 |
| Enterocolitis | 10.69 | 9.71 | 37 | 85156 | 14475 | 79644720 |
| Ataxia | 10.69 | 9.71 | 54 | 85139 | 24985 | 79634210 |
| Emphysema | 10.68 | 9.71 | 40 | 85153 | 16260 | 79642935 |
| Pneumonia aspiration | 10.67 | 9.71 | 114 | 85079 | 66853 | 79592342 |
| End stage renal disease | 10.66 | 9.71 | 33 | 85160 | 12187 | 79647008 |
| Drug resistance | 10.57 | 9.71 | 18 | 85175 | 42195 | 79617000 |
| Abdominal tenderness | 10.56 | 9.71 | 30 | 85163 | 10564 | 79648631 |
| Serotonin syndrome | 10.56 | 9.71 | 20 | 85173 | 45007 | 79614188 |
| Flatulence | 10.54 | 9.71 | 80 | 85113 | 42644 | 79616551 |
| Ocular discomfort | 10.50 | 9.71 | 19 | 85174 | 4964 | 79654231 |
| Gastric dysplasia | 10.46 | 9.71 | 3 | 85190 | 29 | 79659166 |
| Full blood count decreased | 10.45 | 9.71 | 8 | 85185 | 26811 | 79632384 |
| Heart rate decreased | 10.42 | 9.71 | 118 | 85075 | 70198 | 79588997 |
| Device malfunction | 10.30 | 9.71 | 5 | 85188 | 21443 | 79637752 |
| Nephrectomy | 10.30 | 9.71 | 12 | 85181 | 2103 | 79657092 |
| Diverticulum | 10.13 | 9.71 | 37 | 85156 | 14859 | 79644336 |
| Catheter site hypersensitivity | 10.12 | 9.71 | 4 | 85189 | 109 | 79659086 |
| Therapy partial responder | 10.12 | 9.71 | 3 | 85190 | 17394 | 79641801 |
| Tooth disorder | 10.11 | 9.71 | 55 | 85138 | 26178 | 79633017 |
| Cholelithiasis | 10.01 | 9.71 | 93 | 85100 | 52571 | 79606624 |
| Akathisia | 9.94 | 9.71 | 34 | 85159 | 13225 | 79645970 |
| Vocal cord paralysis | 9.89 | 9.71 | 13 | 85180 | 2574 | 79656621 |
| Hypoalbuminaemia | 9.85 | 9.71 | 47 | 85146 | 21250 | 79637945 |
| Breast pain | 9.85 | 9.71 | 25 | 85168 | 8240 | 79650955 |
| Cholangitis acute | 9.74 | 9.71 | 10 | 85183 | 1522 | 79657673 |
| Microcytic anaemia | 9.73 | 9.71 | 19 | 85174 | 5255 | 79653940 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A02BC04 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Proton pump inhibitors |
| ATC | A02BC54 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Proton pump inhibitors |
| ATC | A02BD12 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori |
| ATC | A02BD13 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori |
| FDA MoA | N0000000147 | Proton Pump Inhibitors |
| FDA EPC | N0000175525 | Proton Pump Inhibitor |
| CHEBI has role | CHEBI:49200 | proton pump inhibitors |
| CHEBI has role | CHEBI:49201 | anti-ulcer drugs |
| MeSH PA | D000897 | Anti-Ulcer Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D005765 | Gastrointestinal Agents |
| MeSH PA | D054328 | Proton Pump Inhibitors |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Peptic ulcer | indication | 13200003 | DOID:750 |
| Duodenal ulcer disease | indication | 51868009 | DOID:1724 |
| Zollinger-Ellison syndrome | indication | 53132006 | DOID:0050782 |
| Multiple endocrine adenomas | indication | 60549007 | |
| Gastroesophageal reflux disease | indication | 235595009 | DOID:8534 |
| Systemic mast cell disease | indication | 397016004 | DOID:349 |
| Duodenal Ulcer due to H. Pylori | indication | ||
| Maintenance of Healing Gastroesophageal Reflux | indication | ||
| Pathological Gastric Hypersecretory Condition | indication | ||
| Upper gastrointestinal hemorrhage | off-label use | 37372002 | |
| Prevention of NSAID-Induced Gastric Ulcer | off-label use | ||
| Osteoporosis | contraindication | 64859006 | DOID:11476 |
| Fracture of bone | contraindication | 125605004 | |
| Hypomagnesemia | contraindication | 190855004 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.23 | acidic |
| pKa2 | 3.9 | Basic |
| pKa3 | 2.72 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Potassium-transporting ATPase | Transporter | INHIBITOR | CHEMBL | CHEMBL | |||||
| D(3) dopamine receptor | GPCR | Ki | 6.10 | DRUG MATRIX | |||||
| 5-hydroxytryptamine receptor 1D | GPCR | Ki | 5.12 | WOMBAT-PK | |||||
| Sodium/potassium-transporting ATPase subunit alpha-1 | Transporter | WOMBAT-PK | |||||||
| Adenosine receptor A3 | GPCR | Ki | 5.74 | DRUG MATRIX | |||||
| ATP-binding cassette sub-family G member 2 | Transporter | IC50 | 5.07 | CHEMBL | |||||
| Fatty acid synthase | Enzyme | Ki | 5.23 | CHEMBL | |||||
| Insulin-degrading enzyme | Enzyme | IC50 | 4.96 | CHEMBL | |||||
| N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 | Enzyme | IC50 | 4.28 | CHEMBL | |||||
| Cytosolic endo-beta-N-acetylglucosaminidase | Enzyme | IC50 | 5.35 | CHEMBL | |||||
| Alpha-2B adrenergic receptor | GPCR | Ki | 6.10 | DRUG MATRIX | |||||
| Sterile alpha and TIR motif-containing protein 1 | Unclassified | IC50 | 5.50 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4021174 | VUID |
| N0000148623 | NUI |
| D00724 | KEGG_DRUG |
| 117976-90-6 | SECONDARY_CAS_RN |
| 4021174 | VANDF |
| 4021175 | VANDF |
| C0378482 | UMLSCUI |
| CHEBI:8768 | CHEBI |
| RZX | PDB_CHEM_ID |
| CHEMBL1219 | ChEMBL_ID |
| CHEMBL1200930 | ChEMBL_ID |
| DB01129 | DRUGBANK_ID |
| D064750 | MESH_DESCRIPTOR_UI |
| 5029 | PUBCHEM_CID |
| 7290 | IUPHAR_LIGAND_ID |
| 7112 | INN_ID |
| 32828355LL | UNII |
| 114979 | RXNORM |
| 206957 | MMSL |
| 31277 | MMSL |
| 8292 | MMSL |
| d04448 | MMSL |
| 007680 | NDDF |
| 007681 | NDDF |
| 387013009 | SNOMEDCT_US |
| 421279008 | SNOMEDCT_US |
| 422225001 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Rabeprazole sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-107 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 28 sections |
| Rabeprazole sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-107 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 28 sections |
| Rabeprazole sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-107 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 28 sections |
| Rabeprazole sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-107 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 28 sections |
| Rabeprazole Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42291-722 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 31 sections |
| Rabeprazole Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45865-123 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 27 sections |
| RABEPRAZOLE SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45865-802 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 27 sections |
| RABEPRAZOLE SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-1424 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 27 sections |
| Rabeprazole Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-3145 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 29 sections |
| Rabeprazole sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-3182 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 29 sections |
| Rabeprazole Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-3430 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 30 sections |
| Rabeprazole Sodium | Human Prescription Drug Label | 1 | 50090-4751 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 28 sections |
| Rabeprazole Sodium | Human Prescription Drug Label | 1 | 50090-4751 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 28 sections |
| Rabeprazole Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50436-0302 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 28 sections |
| Rabeprazole Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50436-0724 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 20 sections |
| Rabeprazole Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51407-184 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 29 sections |
| Rabeprazole Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51407-184 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 29 sections |
| Aciphex | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-4185 | TABLET, DELAYED RELEASE | 20 mg | ORAL | NDA | 28 sections |
| Rabeprazole Sodium | Human Prescription Drug Label | 1 | 55700-767 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 27 sections |
| Rabeprazole Sodium | Human Prescription Drug Label | 1 | 55700-767 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 27 sections |
| Rabeprazole Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60760-560 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 27 sections |
| RABEPRAZOLE SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60760-972 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 26 sections |
| RABERPRAZOLE SODIUM D/R | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61919-225 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 16 sections |
| RABERPRAZOLE SODIUM D/R | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61919-225 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 16 sections |
| RABERPRAZOLE SODIUM D/R | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61919-225 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 16 sections |
| RABERPRAZOLE SODIUM D/R | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61919-225 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 16 sections |
| RABEPRAZOLE SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61919-467 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 17 sections |
| RABEPRAZOLE SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61919-467 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 17 sections |
| Rabeprazole Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 62135-503 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 20 sections |
| Rabeprazole Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 62175-302 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 29 sections |