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2022 Update-Veterinary Drugs & Uses
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DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
Search
Structure ๐
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L1000
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
quinupristin ๐ถ
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
antibacterials, streptogramins, protein-synthesis inhibitors, pristinamycin derivatives
2349
120138-50-3
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
quinupristin mesilate
quinupristin
quinupristin mesylate
component of RP 59500
Molecular weight: 1022.23
Formula: C53H67N9O10S
CLOGP: 7.30
LIPINSKI: 3
HAC: 19
HDO: 4
TPSA: 231.20
ALOGS: -4.36
ROTB: 10
Status: OFP
Legend:
OFP - off patent
OFM - off market
ONP - on patent
Drug dosage:
Dose
Unit
Route
1.50
g
P
ADMET properties:
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Property
Value
Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)
4.40 ยตM/kg/day
Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System)
4
Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)
3.50 %
Benet LZ, Broccatelli F, Oprea TI
CL (Clearance)
16 mL/min/kg
Lombardo F, Berellini G, Obach RS
t_half (Half-life)
0.87 hours
Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)
0.67 L/kg
Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)
0.34 %
Lombardo F, Berellini G, Obach RS
S (Water solubility)
0.00 mg/mL
Bocci G, Oprea TI, Benet LZ
Showing 1 to 8 of 8 entries
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Approvals:
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Date
Agency
Company
Orphan
Sept. 21, 1999
FDA
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
J01FG02
ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
Streptogramins
FDA CS
M0022748
Streptogramins
FDA EPC
N0000175502
Streptogramin Antibacterial
MeSH PA
D000900
Anti-Bacterial Agents
MeSH PA
D000890
Anti-Infective Agents
Showing 1 to 5 of 5 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Vancomycin resistant enterococcus
indication
113727004
Streptococcus pyogenes infection
indication
302809008
Complicated Skin and Skin Structure Staphylococcus Aureus Infection
indication
Pyrexia of unknown origin
off-label use
7520000
Hyperbilirubinemia
contraindication
14783006
DOID:2741
Disease of liver
contraindication
235856003
DOID:409
Pseudomembranous enterocolitis
contraindication
397683000
Showing 1 to 7 of 7 entries
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๐ถ Veterinary Drug Use
None
๐ถ Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
6.19
acidic
pKa2
8.42
Basic
pKa3
4.85
Basic
pKa4
2.23
Basic
Showing 1 to 4 of 4 entries
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
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ID
Source
H8Q
PDB_CHEM_ID
007887
NDDF
10798
IUPHAR_LIGAND_ID
116110009
SNOMEDCT_US
229367
RXNORM
23OW28RS7P
UNII
387015002
SNOMEDCT_US
4021184
VUID
4021184
VANDF
441592000
SNOMEDCT_US
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Pharmaceutical products:
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Product
Category
Ingredients
NDC
Form
Quantity
Route
Marketing
Label
Synercid
HUMAN PRESCRIPTION DRUG LABEL
2
61570-260
INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
150 mg
INTRAVENOUS
NDA
26 sections
Synercid
HUMAN PRESCRIPTION DRUG LABEL
2
61570-260
INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
150 mg
INTRAVENOUS
NDA
26 sections
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quinupristin