quinagolide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
dopamine receptor agonists, ergoline derivatives 2339 87056-78-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • quinagolide
  • norprolac
  • Molecular weight: 395.56
  • Formula: C20H33N3O3S
  • CLOGP: 3.72
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 72.88
  • ALOGS: -3.41
  • ROTB: 5

Drug dosage:

DoseUnitRoute
75 mcg O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neutropenia 16.67 0 3 2 21545 2336535

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
ATC G02CB04 GENITO URINARY SYSTEM AND SEX HORMONES
OTHER GYNECOLOGICALS
OTHER GYNECOLOGICALS
Prolactine inhibitors
MeSH PA D015259 Dopamine Agents
MeSH PA D018491 Dopamine Agonists
MeSH PA D018377 Neurotransmitter Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.45 acidic
pKa2 11.15 acidic
pKa3 8.35 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Dopamine receptor GPCR IC50 7.72 CHEMBL
Adrenergic receptor alpha-1 GPCR IC50 5.22 CHEMBL
Adrenergic receptor alpha-2 GPCR IC50 5.25 CHEMBL
Serotonin (5-HT) receptor GPCR IC50 5.64 CHEMBL

External reference:

IDSource
C0256089 UMLSCUI
D07217 KEGG_DRUG
326066005 SNOMEDCT_US
005470 NDDF
76887 RXNORM
395850005 SNOMEDCT_US
80Q9QWN15M UNII
6545 INN_ID
CHEMBL290962 ChEMBL_ID
DB09097 DRUGBANK_ID
CHEBI:135627 CHEBI
CHEMBL2218861 ChEMBL_ID
3086401 PUBCHEM_CID
C046650 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None