quetiapine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
psychoactive 2337 111974-69-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • quetiapine
  • quetiapine fumarate
  • quetiapine hemifumarate
  • ICI 204,636
  • seroquel
A dibenzothiazepine and ANTIPSYCHOTIC AGENT that targets the SEROTONIN 5-HT2 RECEPTOR; HISTAMINE H1 RECEPTOR, adrenergic alpha1 and alpha2 receptors, as well as the DOPAMINE D1 RECEPTOR and DOPAMINE D2 RECEPTOR. It is used in the treatment of SCHIZOPHRENIA; BIPOLAR DISORDER and DEPRESSIVE DISORDER.
  • Molecular weight: 383.51
  • Formula: C21H25N3O2S
  • CLOGP: 2.99
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 48.30
  • ALOGS: -3.98
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.40 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 94 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 34.68 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 9 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Sept. 26, 1997 FDA ASTRAZENECA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 3451.75 10.40 3277 203370 130556 55954864
Toxicity to various agents 3036.79 10.40 3918 202729 220646 55864774
Drug abuse 2770.56 10.40 2160 204487 65450 56019970
Intentional overdose 2713.05 10.40 2140 204507 65977 56019443
Suicide attempt 2613.86 10.40 1959 204688 55877 56029543
Sopor 2560.50 10.40 1336 205311 19586 56065834
Intentional self-injury 1472.92 10.40 996 205651 23996 56061424
Overdose 1387.21 10.40 1822 204825 104008 55981412
Neuroleptic malignant syndrome 1378.25 10.40 724 205923 10754 56074666
Drug interaction 1101.43 10.40 2397 204250 207358 55878062
Sedation 994.87 10.40 905 205742 33949 56051471
Somnolence 973.29 10.40 1967 204680 161446 55923974
Electrocardiogram QT prolonged 956.70 10.40 1089 205558 53499 56031921
Coma 902.79 10.40 1104 205543 58551 56026869
Dystonia 838.45 10.40 539 206108 11882 56073538
Tardive dyskinesia 803.65 10.40 449 206198 7582 56077838
Suicidal ideation 724.70 10.40 974 205673 56768 56028652
Schizophrenia 702.22 10.40 453 206194 10046 56075374
Gestational diabetes 655.79 10.40 394 206253 7670 56077750
Psychotic disorder 651.26 10.40 601 206046 22957 56062463
Akathisia 640.31 10.40 398 206249 8254 56077166
Dyskinesia 636.58 10.40 653 205994 28455 56056965
Agitation 623.43 10.40 892 205755 55144 56030276
Depressed level of consciousness 582.35 10.40 867 205780 55566 56029854
Mania 582.24 10.40 418 206229 11102 56074318
Extrapyramidal disorder 558.25 10.40 419 206228 11937 56073483
Blood prolactin abnormal 454.29 10.40 202 206445 2023 56083397
Serotonin syndrome 452.87 10.40 522 206125 25968 56059452
Arthralgia 443.79 10.40 725 205922 500944 55584476
Sexual dysfunction 436.12 10.40 224 206423 3164 56082256
Tachycardia 428.02 10.40 1094 205553 104782 55980638
Diabetes mellitus 425.27 10.40 724 205923 52011 56033409
Parkinsonism 423.00 10.40 320 206327 9226 56076194
Muscle rigidity 421.20 10.40 334 206313 10337 56075083
Poisoning 415.87 10.40 358 206289 12455 56072965
Hallucination, auditory 398.64 10.40 334 206313 11190 56074230
Anosognosia 377.00 10.40 179 206468 2110 56083310
Diarrhoea 370.70 10.40 1161 205486 637346 55448074
Delusion 361.24 10.40 312 206335 10903 56074517
Bradyphrenia 359.49 10.40 251 206396 6369 56079051
Liver injury 347.27 10.40 582 206065 41266 56044154
Dyspnoea 345.57 10.40 1075 205572 591502 55493918
Hallucination 344.95 10.40 635 206012 48514 56036906
Disturbance in social behaviour 340.06 10.40 183 206464 2858 56082562
Cardio-respiratory arrest 338.16 10.40 674 205973 54647 56030773
Altered state of consciousness 336.60 10.40 419 206228 22602 56062818
Pain 327.80 10.40 1291 205356 661893 55423527
Poisoning deliberate 324.85 10.40 279 206368 9674 56075746
Aggression 320.91 10.40 400 206247 21606 56063814
Restlessness 318.98 10.40 439 206208 26147 56059273
Joint swelling 313.89 10.40 361 206286 289439 55795981
Rheumatoid arthritis 308.80 10.40 585 206062 382019 55703401
Bradykinesia 308.79 10.40 203 206444 4651 56080769
Rash 296.02 10.40 882 205765 492165 55593255
Exposure during pregnancy 292.50 10.40 1131 205516 135211 55950209
Delirium 287.93 10.40 541 206106 41976 56043444
Respiratory arrest 286.84 10.40 450 206197 30175 56055245
Metabolic disorder 284.78 10.40 202 206445 5259 56080161
Tremor 276.68 10.40 1025 205622 120064 55965356
Abnormal behaviour 274.27 10.40 355 206292 19917 56065503
Bipolar disorder 271.11 10.40 224 206423 7356 56078064
Sinusitis 265.76 10.40 202 206445 197379 55888041
Peripheral swelling 264.39 10.40 283 206364 234443 55850977
Personality change 262.16 10.40 197 206450 5620 56079800
Hypomania 259.51 10.40 183 206464 4719 56080701
Pain in extremity 259.44 10.40 433 206214 296998 55788422
Bezoar 256.41 10.40 117 206530 1251 56084169
Pruritus 245.86 10.40 495 206152 316128 55769292
Cardiac arrest 242.75 10.40 783 205864 85531 55999889
Confusional state 242.19 10.40 1447 205200 206708 55878712
Nasopharyngitis 240.46 10.40 274 206373 220685 55864735
Intentional product misuse 239.64 10.40 562 206085 50942 56034478
Seizure 234.94 10.40 996 205651 124123 55961297
Loss of consciousness 234.37 10.40 907 205740 108442 55976978
Mydriasis 234.08 10.40 244 206403 10827 56074593
Cough 227.98 10.40 377 206270 259584 55825836
Fatigue 227.86 10.40 1831 204816 786721 55298699
Anticholinergic syndrome 226.42 10.40 120 206527 1814 56083606
Galactorrhoea 226.37 10.40 154 206493 3741 56081679
Sinus tachycardia 221.66 10.40 338 206309 22106 56063314
Psychomotor hyperactivity 217.68 10.40 222 206425 9598 56075822
Febrile neutropenia 217.67 10.40 59 206588 105486 55979934
Stubbornness 216.24 10.40 70 206577 255 56085165
Drug hypersensitivity 213.79 10.40 430 206217 274775 55810645
Infection 207.42 10.40 258 206389 199948 55885472
Hyperprolactinaemia 206.26 10.40 142 206505 3519 56081901
Hallucinations, mixed 199.75 10.40 150 206497 4274 56081146
Back pain 198.72 10.40 354 206293 236816 55848604
Headache 192.17 10.40 1234 205413 557810 55527610
Disorientation 190.87 10.40 418 206229 36195 56049225
Anxiety 189.43 10.40 1286 205361 191886 55893534
Urinary retention 186.05 10.40 354 206293 27720 56057700
Malignant neoplasm progression 185.78 10.40 25 206622 73562 56011858
Disease progression 183.57 10.40 78 206569 105095 55980325
Metabolic syndrome 181.90 10.40 93 206554 1300 56084120
Hypersensitivity 179.78 10.40 424 206223 255984 55829436
Nausea 178.20 10.40 1872 204775 762306 55323114
Restless legs syndrome 175.57 10.40 261 206386 16686 56068734
Pneumonia 170.98 10.40 841 205806 406257 55679163
Disturbance in attention 169.05 10.40 371 206276 32169 56053251
Drug intolerance 166.33 10.40 463 206184 264355 55821065
Speech disorder 162.41 10.40 398 206249 37095 56048325
Paranoia 157.75 10.40 196 206451 10548 56074872
Diabetic coma 157.33 10.40 68 206579 632 56084788
Obesity 156.14 10.40 289 206358 22159 56063261
Suspected suicide 155.97 10.40 142 206505 5324 56080096
Labour complication 152.72 10.40 41 206606 59 56085361
Anaemia 149.88 10.40 493 206154 267018 55818402
Antipsychotic drug level increased 148.78 10.40 111 206536 3131 56082289
Hypotension 148.48 10.40 1488 205159 249020 55836400
Substance abuse 147.97 10.40 127 206520 4398 56081022
Respiratory depression 147.13 10.40 204 206443 12231 56073189
Depression 143.84 10.40 1142 205505 178975 55906445
Herpes zoster 142.83 10.40 50 206597 75839 56009581
Thinking abnormal 142.20 10.40 179 206468 9762 56075658
Blood prolactin increased 140.15 10.40 108 206539 3201 56082219
Dysarthria 139.71 10.40 389 206258 39161 56046259
Oculogyric crisis 138.43 10.40 80 206567 1444 56083976
Infusion related reaction 138.15 10.40 356 206291 208575 55876845
Cogwheel rigidity 135.47 10.40 85 206562 1792 56083628
Depersonalisation/derealisation disorder 134.76 10.40 74 206573 1205 56084215
Blood creatine phosphokinase increased 133.25 10.40 308 206339 27644 56057776
Withdrawal syndrome 132.59 10.40 241 206406 18221 56067199
Synovitis 132.11 10.40 244 206403 161061 55924359
Miosis 131.74 10.40 141 206506 6451 56078969
Treatment noncompliance 130.50 10.40 336 206311 32287 56053133
Catatonia 129.11 10.40 111 206536 3853 56081567
Electrocardiogram QRS complex prolonged 127.41 10.40 127 206520 5340 56080080
Injection site erythema 126.49 10.40 63 206584 77385 56008035
Derealisation 126.34 10.40 67 206580 1014 56084406
Neuropathy peripheral 126.13 10.40 115 206532 102778 55982642
Drug ineffective 125.04 10.40 2504 204143 916485 55168935
Hyperammonaemic encephalopathy 123.68 10.40 85 206562 2100 56083320
Irritability 122.78 10.40 309 206338 29279 56056141
Erythema 122.36 10.40 242 206405 155697 55929723
Coma scale abnormal 120.84 10.40 117 206530 4746 56080674
Swelling 119.54 10.40 464 206183 239307 55846113
Persecutory delusion 117.95 10.40 88 206559 2482 56082938
Gastrointestinal disorder 116.87 10.40 145 206502 112557 55972863
Pleurothotonus 116.42 10.40 68 206579 1253 56084167
Drug withdrawal syndrome 115.74 10.40 278 206369 25579 56059841
Prescribed overdose 115.57 10.40 254 206393 22042 56063378
Cardiac failure congestive 114.89 10.40 92 206555 87628 55997792
Urinary tract infection 114.48 10.40 474 206173 240039 55845381
Unresponsive to stimuli 112.01 10.40 312 206335 31413 56054007
Mental disorder 111.32 10.40 259 206388 23345 56062075
Bipolar I disorder 110.72 10.40 72 206575 1618 56083802
Stomatitis 110.66 10.40 170 206477 120640 55964780
Sepsis 108.85 10.40 218 206429 139622 55945798
Type 2 diabetes mellitus 107.99 10.40 398 206249 46464 56038956
Orthostatic hypertension 107.72 10.40 44 206603 350 56085070
Obsessive-compulsive disorder 107.16 10.40 97 206550 3609 56081811
Pyrexia 107.12 10.40 1002 205645 417771 55667649
Mucosal inflammation 106.97 10.40 15 206632 42795 56042625
Injection site pain 106.13 10.40 166 206481 116952 55968468
Drug withdrawal syndrome neonatal 106.11 10.40 75 206572 1941 56083479
Urticaria 105.52 10.40 234 206413 144442 55940978
Myoclonus 104.81 10.40 195 206452 15008 56070412
Lower respiratory tract infection 104.70 10.40 162 206485 114632 55970788
Mood altered 104.48 10.40 181 206466 13174 56072246
Plasma cell myeloma 104.15 10.40 22 206625 46624 56038796
Arthritis 104.02 10.40 128 206519 99724 55985696
Feeling of despair 103.93 10.40 76 206571 2077 56083343
Rhabdomyolysis 102.82 10.40 356 206291 40302 56045118
Hallucination, visual 102.11 10.40 209 206438 17259 56068161
Influenza 101.48 10.40 120 206527 95141 55990279
Psychomotor retardation 100.18 10.40 93 206554 3576 56081844
Mood swings 98.64 10.40 201 206446 16546 56068874
Malaise 96.70 10.40 874 205773 366986 55718434
Somnambulism 96.65 10.40 106 206541 4986 56080434
Nightmare 94.46 10.40 198 206449 16628 56068792
Atrial fibrillation 94.31 10.40 159 206488 108738 55976682
Torsade de pointes 93.94 10.40 166 206481 12274 56073146
Dissociation 93.71 10.40 77 206570 2508 56082912
Circulatory collapse 93.46 10.40 224 206423 20579 56064841
Salivary hypersecretion 93.07 10.40 122 206525 6928 56078492
Hypokinesia 93.04 10.40 168 206479 12635 56072785
Therapeutic product effect decreased 92.94 10.40 315 206332 169137 55916283
Disorganised speech 92.91 10.40 55 206592 1040 56084380
Sleep-related eating disorder 91.62 10.40 49 206598 755 56084665
Weight increased 91.32 10.40 1264 205383 228439 55856981
Impaired healing 89.74 10.40 112 206535 86729 55998691
Hypotonia 88.96 10.40 133 206514 8544 56076876
Pneumonia aspiration 88.31 10.40 291 206356 32120 56053300
Treatment failure 87.28 10.40 326 206321 170066 55915354
Gastric pH decreased 86.77 10.40 45 206602 649 56084771
Psychomotor skills impaired 86.63 10.40 68 206579 2072 56083348
Foetal exposure during pregnancy 85.39 10.40 296 206351 33527 56051893
Impulse-control disorder 85.03 10.40 45 206602 678 56084742
Haemoglobin decreased 84.48 10.40 234 206413 133903 55951517
Platelet count decreased 83.50 10.40 165 206482 106218 55979202
Suicidal behaviour 83.06 10.40 70 206577 2363 56083057
Skin ulcer 82.60 10.40 20 206627 38588 56046832
Cellulitis 82.43 10.40 92 206555 74857 56010563
Psoriasis 80.57 10.40 135 206512 92557 55992863
Breast cancer 79.31 10.40 40 206607 48793 56036627
Psoriatic arthropathy 79.26 10.40 504 206143 73504 56011916
Alopecia 78.91 10.40 693 205954 292765 55792655
Drooling 77.45 10.40 79 206568 3415 56082005
Myoglobin urine present 77.44 10.40 39 206608 527 56084893
Hyperreflexia 77.43 10.40 96 206551 5154 56080266
Bronchitis 76.78 10.40 188 206459 112123 55973297
Long QT syndrome 76.42 10.40 74 206573 3002 56082418
Bone pain 75.85 10.40 45 206602 50140 56035280
Anger 74.64 10.40 145 206502 11527 56073893
Drug screen positive 74.40 10.40 77 206570 3387 56082033
Abdominal discomfort 74.00 10.40 656 205991 276618 55808802
Coma blister 73.94 10.40 26 206621 129 56085291
Flushing 73.91 10.40 89 206558 70011 56015409
Chest discomfort 71.15 10.40 161 206486 98696 55986724
COVID-19 70.28 10.40 104 206543 74954 56010466
Injection site pruritus 70.14 10.40 33 206614 41898 56043522
Infarction 70.12 10.40 64 206583 2407 56083013
Injection site swelling 68.84 10.40 37 206610 43541 56041879
Dyspnoea exertional 68.34 10.40 60 206587 54629 56030791
Stupor 68.34 10.40 79 206568 3939 56081481
Accidental overdose 68.10 10.40 197 206450 20264 56065156
Oromandibular dystonia 67.68 10.40 33 206614 414 56085006
Cognitive disorder 67.18 10.40 357 206290 48776 56036644
Generalised tonic-clonic seizure 66.78 10.40 238 206409 27328 56058092
Drug level increased 66.54 10.40 197 206450 20528 56064892
Panic attack 66.26 10.40 195 206452 20252 56065168
Depressed mood 66.25 10.40 287 206360 36072 56049348
Potentiating drug interaction 65.92 10.40 78 206569 3988 56081432
Dementia 65.82 10.40 174 206473 16984 56068436
Psychiatric symptom 65.77 10.40 85 206562 4759 56080661
Gastrointestinal haemorrhage 65.65 10.40 111 206536 75840 56009580
Electrocardiogram QRS complex shortened 65.32 10.40 32 206615 406 56085014
Apathy 65.11 10.40 110 206537 7844 56077576
Interstitial lung disease 65.02 10.40 68 206579 56995 56028425
Upper respiratory tract infection 64.60 10.40 101 206546 71187 56014233
Nasal congestion 64.42 10.40 67 206580 56303 56029117
Pancytopenia 64.24 10.40 144 206503 88571 55996849
Sleep disorder due to general medical condition, insomnia type 63.90 10.40 40 206607 43298 56042122
Hyperthermia 63.13 10.40 111 206536 8174 56077246
Device expulsion 62.78 10.40 17 206630 30432 56054988
Schizoaffective disorder 62.34 10.40 65 206582 2884 56082536
Bone marrow failure 61.80 10.40 14 206633 28272 56057148
Amenorrhoea 61.62 10.40 115 206532 8871 56076549
Exposure via ingestion 61.36 10.40 63 206584 2745 56082675
Bradypnoea 61.36 10.40 67 206580 3136 56082284
Behaviour disorder 61.34 10.40 62 206585 2651 56082769
Osteonecrosis of jaw 61.02 10.40 23 206624 33335 56052085
Red blood cell sedimentation rate increased 60.99 10.40 29 206618 36594 56048826
Chest pain 59.87 10.40 429 206218 189368 55896052
Hypotonia neonatal 59.58 10.40 42 206605 1082 56084338
Drug dependence 59.33 10.40 200 206447 22333 56063087
Tachyphrenia 59.00 10.40 44 206603 1240 56084180
Hypothermia 58.98 10.40 137 206510 12333 56073087
Embolism venous 58.83 10.40 62 206585 2786 56082634
Basal cell carcinoma 58.17 10.40 11 206636 25210 56060210
Dyspepsia 57.61 10.40 139 206508 83332 56002088
Product dose omission issue 57.46 10.40 478 206169 204275 55881145
Musculoskeletal pain 56.91 10.40 134 206513 81018 56004402
Euphoric mood 56.88 10.40 75 206572 4283 56081137
Mutism 56.85 10.40 45 206602 1388 56084032
Myalgia 56.82 10.40 270 206377 131755 55953665
Injection site reaction 56.77 10.40 67 206580 53180 56032240
Abnormal weight gain 56.75 10.40 46 206601 1469 56083951
Fluid retention 56.64 10.40 69 206578 54009 56031411
Diverticulitis 55.81 10.40 31 206616 35821 56049599
Rhinorrhoea 55.40 10.40 77 206570 56960 56028460
Pleural effusion 55.39 10.40 147 206500 85333 56000087
Gastrooesophageal reflux disease 54.85 10.40 142 206505 83115 56002305
Contusion 54.48 10.40 264 206383 128166 55957254
Urinary hesitation 54.29 10.40 51 206596 1991 56083429
Prescribed underdose 54.29 10.40 183 206464 20434 56064986
Myocardial infarction 54.10 10.40 168 206479 92702 55992718
Logorrhoea 53.64 10.40 54 206593 2298 56083122
Conversion disorder 53.61 10.40 46 206601 1592 56083828
Palmar-plantar erythrodysaesthesia syndrome 53.53 10.40 7 206640 21058 56064362
Medication error 53.44 10.40 301 206346 42034 56043386
H1N1 influenza 53.39 10.40 46 206601 1601 56083819
Sympathomimetic effect 53.33 10.40 16 206631 42 56085378
Psychiatric decompensation 53.05 10.40 42 206605 1296 56084124
Tic 52.78 10.40 41 206606 1230 56084190
Chills 52.71 10.40 196 206451 102408 55983012
Cytomegalovirus infection 52.59 10.40 5 206642 19291 56066129
Productive cough 52.55 10.40 78 206569 56154 56029266
Thrombosis 52.14 10.40 86 206561 59341 56026079
Major depression 51.93 10.40 97 206550 7487 56077933
Myelosuppression 51.90 10.40 3 206644 17452 56067968
Myocarditis 51.79 10.40 106 206541 8752 56076668
Asthenia 51.64 10.40 917 205730 342056 55743364
Posture abnormal 51.11 10.40 51 206596 2147 56083273
Epistaxis 50.83 10.40 106 206541 66917 56018503
Polydipsia 50.70 10.40 61 206586 3174 56082246
Thermal burn 50.51 10.40 80 206567 5405 56080015
Leukopenia 50.22 10.40 438 206209 70502 56014918
Menstrual disorder 49.86 10.40 73 206574 4602 56080818
Loss of personal independence in daily activities 49.69 10.40 144 206503 81225 56004195
Irritable bowel syndrome 49.65 10.40 111 206536 68347 56017073
Hyperkinesia 49.57 10.40 44 206603 1595 56083825
Neoplasm progression 49.38 10.40 28 206619 31988 56053432
Acute psychosis 48.95 10.40 51 206596 2261 56083159
Pulmonary arterial hypertension 48.94 10.40 18 206629 26485 56058935
Enuresis 48.75 10.40 51 206596 2272 56083148
Weight decreased 48.51 10.40 608 206039 240106 55845314
Anaphylactic reaction 48.46 10.40 89 206558 58906 56026514
Asthma 48.29 10.40 231 206416 112539 55972881
Pancreatitis 48.25 10.40 307 206340 44773 56040647
Full blood count decreased 48.21 10.40 13 206634 23336 56062084
Blood pressure increased 47.80 10.40 324 206323 144852 55940568
Hypersomnia 47.48 10.40 150 206497 16191 56069229
Blood triglycerides increased 47.44 10.40 121 206526 11556 56073864
Dry skin 47.37 10.40 62 206585 47047 56038373
Therapeutic product effect incomplete 47.29 10.40 214 206433 105817 55979603
Faecaloma 47.04 10.40 92 206555 7349 56078071
Impulsive behaviour 46.66 10.40 41 206606 1466 56083954
Rabbit syndrome 46.32 10.40 23 206624 301 56085119
Clonus 46.26 10.40 67 206580 4182 56081238
Bundle branch block right 46.17 10.40 71 206576 4676 56080744
Jaundice cholestatic 46.08 10.40 77 206570 5442 56079978
Osteonecrosis 45.95 10.40 14 206633 23201 56062219
Ascites 45.94 10.40 42 206605 37502 56047918
Abdominal pain 45.91 10.40 671 205976 258134 55827286
Hypersexuality 45.90 10.40 26 206621 451 56084969
Pneumocystis jirovecii pneumonia 45.78 10.40 3 206644 15698 56069722
Mental impairment 45.77 10.40 126 206521 12596 56072824
Tension 45.60 10.40 55 206592 2869 56082551
Localised infection 45.20 10.40 22 206625 27390 56058030
Urine osmolarity increased 44.74 10.40 17 206630 109 56085311
Parkinsonian gait 44.42 10.40 25 206622 428 56084992
Hypervolaemia 43.98 10.40 21 206626 26437 56058983
Nephrogenic diabetes insipidus 43.97 10.40 32 206615 868 56084552
Schizophreniform disorder 43.93 10.40 15 206632 67 56085353
Postural tremor 43.90 10.40 20 206627 213 56085207
Injection site bruising 43.77 10.40 46 206601 38475 56046945
Psychotic behaviour 42.95 10.40 27 206620 571 56084849
Intestinal pseudo-obstruction 42.76 10.40 30 206617 767 56084653
Surgery 42.61 10.40 34 206613 32452 56052968
Aspiration 42.57 10.40 103 206544 9518 56075902
Meconium aspiration syndrome 42.19 10.40 11 206636 13 56085407
Pain in jaw 42.02 10.40 51 206596 39985 56045435
Ventricular fibrillation 41.94 10.40 111 206536 10841 56074579
Bradycardia 41.82 10.40 405 206242 67099 56018321
Anaemia of pregnancy 41.77 10.40 15 206632 80 56085340
Joint stiffness 41.74 10.40 41 206606 35384 56050036
Action tremor 41.62 10.40 21 206626 285 56085135
Alcohol interaction 41.59 10.40 47 206600 2286 56083134
Feeling of body temperature change 40.98 10.40 66 206581 4523 56080897
Thrombocytopenia 40.97 10.40 312 206335 135912 55949508
Alcohol abuse 40.64 10.40 43 206604 1941 56083479
Insurance issue 40.13 10.40 59 206588 3733 56081687
Rash pruritic 40.03 10.40 83 206564 52511 56032909
Metastases to bone 40.02 10.40 11 206636 19497 56065923
Viral infection 39.97 10.40 35 206612 31911 56053509
Oropharyngeal pain 39.87 10.40 165 206482 83623 56001797
Homicide 39.86 10.40 22 206625 362 56085058
Osteoarthritis 39.55 10.40 156 206491 80140 56005280
Throat irritation 39.47 10.40 37 206610 32646 56052774
Osteomyelitis 39.44 10.40 20 206627 24326 56061094
Adjustment disorder with mixed anxiety and depressed mood 39.40 10.40 14 206633 72 56085348
Burning mouth syndrome 39.32 10.40 23 206624 425 56084995
Metastases to liver 39.29 10.40 15 206632 21571 56063849
Right ventricular false tendon 39.22 10.40 10 206637 10 56085410
Affect lability 39.16 10.40 103 206544 10022 56075398
Negativism 38.87 10.40 22 206625 381 56085039
Conjunctival abrasion 38.72 10.40 11 206636 22 56085398
Folliculitis 38.37 10.40 91 206556 54888 56030532
Apraxia 38.35 10.40 39 206608 1680 56083740
Muscle injury 38.17 10.40 85 206562 52415 56033005
Borderline personality disorder 38.09 10.40 27 206620 702 56084718
Acute myeloid leukaemia 37.89 10.40 8 206639 16964 56068456
Amniotic fluid volume increased 37.76 10.40 16 206631 141 56085279
Labelled drug-drug interaction issue 37.73 10.40 28 206619 783 56084637
Nephrolithiasis 37.68 10.40 49 206598 37286 56048134
Clostridium difficile colitis 37.63 10.40 11 206636 18727 56066693
Neoplasm malignant 37.16 10.40 27 206620 27028 56058392
Hypertension 37.08 10.40 652 205995 243626 55841794
Refusal of examination 36.90 10.40 16 206631 150 56085270
Respiratory tract infection 36.75 10.40 47 206600 36024 56049396
Food interaction 36.70 10.40 27 206620 745 56084675
Ataxia 36.30 10.40 126 206521 14277 56071143
Memory impairment 36.24 10.40 481 206166 86076 55999344
Granulocytopenia 36.15 10.40 68 206579 5276 56080144
Hyperammonaemia 36.12 10.40 65 206582 4875 56080545
Social anxiety disorder 35.86 10.40 21 206626 389 56085031
Muscle twitching 35.78 10.40 136 206511 16106 56069314
Gastrointestinal sounds abnormal 35.73 10.40 56 206591 3749 56081671
Neck pain 35.39 10.40 112 206535 61443 56023977
Hypercalcaemia 35.38 10.40 25 206622 25386 56060034
Discomfort 35.33 10.40 341 206306 141420 55944000
Product substitution issue 35.32 10.40 126 206521 14473 56070947
Hyperphagia 35.22 10.40 36 206611 1560 56083860
Disinhibition 35.22 10.40 27 206620 794 56084626
Congenital vesicoureteric reflux 35.20 10.40 10 206637 20 56085400
Homicidal ideation 34.95 10.40 37 206610 1671 56083749
Emotional disorder 34.94 10.40 112 206535 12183 56073237
Decreased appetite 34.93 10.40 580 206067 218651 55866769
Laboratory test abnormal 34.77 10.40 24 206623 24671 56060749
Contraindicated product administered 34.77 10.40 478 206169 185808 55899612
Self-injurious ideation 34.70 10.40 43 206604 2307 56083113
Renal failure 34.70 10.40 250 206397 110250 55975170
Alcohol poisoning 34.48 10.40 38 206609 1797 56083623
Tongue biting 34.44 10.40 33 206614 1321 56084099
Renal papillary necrosis 34.40 10.40 17 206630 220 56085200
Femur fracture 34.35 10.40 57 206590 39238 56046182
Accidental poisoning 34.02 10.40 24 206623 619 56084801
Self esteem decreased 33.87 10.40 23 206624 557 56084863
Atrioventricular block first degree 33.85 10.40 76 206571 6689 56078731
Adrenal insufficiency 33.83 10.40 8 206639 15689 56069731
Nodule 33.78 10.40 13 206634 18606 56066814
Rectal haemorrhage 33.66 10.40 63 206584 41404 56044016
Slow response to stimuli 33.46 10.40 28 206619 936 56084484
Congenital hand malformation 33.45 10.40 18 206629 281 56085139
Arrhythmia 33.36 10.40 232 206415 34851 56050569
Congenital thrombocytopenia 33.18 10.40 11 206636 44 56085376
Breast cancer metastatic 33.11 10.40 8 206639 15461 56069959
Full blood count abnormal 33.10 10.40 29 206618 26433 56058987
Hyperthermia malignant 32.88 10.40 25 206622 726 56084694
Electrocardiogram repolarisation abnormality 32.88 10.40 31 206616 1216 56084204
Hypertonia 32.71 10.40 56 206591 4036 56081384
Stereotypy 32.71 10.40 20 206627 402 56085018
Septic shock 32.70 10.40 114 206533 60721 56024699
Ear infection 32.70 10.40 40 206607 31255 56054165
Colitis 32.66 10.40 65 206582 41746 56043674
Nuchal rigidity 32.61 10.40 23 206624 593 56084827
Coronary artery disease 32.56 10.40 39 206608 30757 56054663
Apnoea 32.55 10.40 78 206569 7164 56078256
Toxic encephalopathy 32.31 10.40 69 206578 5869 56079551
Inappropriate affect 32.27 10.40 26 206621 823 56084597
Amnesia 32.26 10.40 285 206362 46037 56039383
Inflammation 32.25 10.40 137 206510 68934 56016486
Neutropenic sepsis 32.22 10.40 8 206639 15177 56070243
Anaphylactic shock 32.14 10.40 20 206627 21720 56063700
Persistent genital arousal disorder 31.99 10.40 18 206629 308 56085112
Bone disorder 31.74 10.40 16 206631 19527 56065893
Fungal infection 31.58 10.40 45 206602 32948 56052472
Self-medication 31.23 10.40 42 206605 2445 56082975
Limb discomfort 31.15 10.40 31 206616 26591 56058829
Metabolic acidosis 30.86 10.40 254 206393 40200 56045220
Foetal death 30.85 10.40 85 206562 8502 56076918
Emotional poverty 30.80 10.40 18 206629 332 56085088
Sinus disorder 30.75 10.40 19 206628 20715 56064705
Bone density decreased 30.66 10.40 5 206642 12755 56072665
Attention deficit hyperactivity disorder 30.59 10.40 43 206604 2611 56082809
Myelodysplastic syndrome 30.53 10.40 11 206636 16395 56069025
Injection site rash 30.50 10.40 12 206635 16946 56068474
Distributive shock 30.46 10.40 28 206619 1063 56084357
Depressive symptom 30.36 10.40 50 206597 3491 56081929
Oral pain 30.32 10.40 31 206616 26262 56059158
Colitis ulcerative 30.18 10.40 27 206620 24364 56061056
Gastric disorder 30.13 10.40 47 206600 33163 56052257
Stoma site discharge 29.81 10.40 31 206616 1371 56084049
Incontinence 29.79 10.40 97 206550 10638 56074782
Renal impairment 29.71 10.40 174 206473 80539 56004881
Abdominal pain upper 29.64 10.40 468 206179 177845 55907575
Feeling guilty 29.62 10.40 21 206626 546 56084874
Anti-cyclic citrullinated peptide antibody positive 29.56 10.40 226 206421 98374 55987046
Acute kidney injury 29.49 10.40 666 205981 240097 55845323
Hand deformity 29.25 10.40 334 206313 134158 55951262
Akinesia 29.20 10.40 32 206615 1504 56083916
Tenderness 29.17 10.40 19 206628 20136 56065284
Foot deformity 28.74 10.40 27 206620 23798 56061622
Tonic clonic movements 28.67 10.40 29 206618 1241 56084179
Electrocardiogram abnormal 28.65 10.40 80 206567 8064 56077356
Blood calcium decreased 28.59 10.40 27 206620 23742 56061678
Injection site urticaria 28.59 10.40 6 206641 12777 56072643
Procedural pain 28.48 10.40 12 206635 16259 56069161
Peripartum cardiomyopathy 28.41 10.40 13 206634 140 56085280
Bacteraemia 28.22 10.40 11 206636 15620 56069800
Hypertonia neonatal 28.17 10.40 15 206632 229 56085191
Immunodeficiency 28.14 10.40 12 206635 16145 56069275
Floppy iris syndrome 28.10 10.40 12 206635 108 56085312
Arthropathy 28.05 10.40 542 206105 199733 55885687
Pulmonary hypertension 27.97 10.40 56 206591 35888 56049532
Vomiting 27.94 10.40 1520 205127 496708 55588712
Mouth ulceration 27.80 10.40 41 206606 29599 56055821
Herbal interaction 27.66 10.40 11 206636 81 56085339
Oedema peripheral 27.62 10.40 452 206195 170802 55914618
Cardiac failure 27.61 10.40 182 206465 81911 56003509
Slow speech 27.61 10.40 29 206618 1298 56084122
Formication 27.46 10.40 51 206596 3919 56081501
Single umbilical artery 27.38 10.40 15 206632 243 56085177
Gastroenteritis viral 27.26 10.40 21 206626 20403 56065017
Breast cancer female 27.17 10.40 6 206641 12332 56073088
Affective disorder 26.98 10.40 62 206585 5541 56079879
Cystitis 26.96 10.40 91 206556 48947 56036473
Torticollis 26.93 10.40 33 206614 1750 56083670
Sinus congestion 26.88 10.40 12 206635 15712 56069708
Urine sodium increased 26.87 10.40 11 206636 88 56085332
Ammonia increased 26.73 10.40 53 206594 4276 56081144
Cytokine release syndrome 26.72 10.40 4 206643 10871 56074549
Cyanosis 26.68 10.40 122 206525 15688 56069732
Facet joint syndrome 26.66 10.40 69 206578 6648 56078772
Personality change due to a general medical condition 26.66 10.40 11 206636 90 56085330
Muscle disorder 26.65 10.40 55 206592 4568 56080852
Antidepressant drug level increased 26.59 10.40 15 206632 258 56085162
Ulcer 26.51 10.40 26 206621 22459 56062961
Pneumonitis 26.47 10.40 47 206600 31517 56053903
Eosinophil count decreased 26.46 10.40 33 206614 1782 56083638
Drug level above therapeutic 26.45 10.40 53 206594 4309 56081111
Musculoskeletal disorder 26.44 10.40 19 206628 19128 56066292
Osteoporosis 26.35 10.40 100 206547 51952 56033468
Language disorder 26.26 10.40 34 206613 1907 56083513
Accidental death 26.22 10.40 33 206614 1799 56083621
Malignant melanoma 26.21 10.40 4 206643 10715 56074705
Ill-defined disorder 26.18 10.40 146 206501 68397 56017023
Decreased interest 26.10 10.40 43 206604 3003 56082417
Incoherent 26.04 10.40 52 206595 4217 56081203
Mobility decreased 26.00 10.40 235 206412 98756 55986664
Parosmia 25.93 10.40 55 206592 4656 56080764
Respiratory disorder neonatal 25.91 10.40 24 206623 920 56084500
Right ventricular failure 25.73 10.40 14 206633 16365 56069055
Disseminated intravascular coagulation 25.69 10.40 17 206630 17868 56067552
Antidepressant drug level above therapeutic 25.61 10.40 17 206630 396 56085024
Blunted affect 25.49 10.40 14 206633 228 56085192
Therapy interrupted 25.48 10.40 34 206613 25591 56059829
Social avoidant behaviour 25.44 10.40 41 206606 2811 56082609
Pyramidal tract syndrome 25.43 10.40 16 206631 339 56085081
Cytopenia 25.37 10.40 3 206644 9752 56075668
Neonatal disorder 25.25 10.40 19 206628 543 56084877
Mental status changes 25.22 10.40 229 206418 37272 56048148
Hyperhidrosis 25.08 10.40 485 206162 93603 55991817
Orthostatic hypotension 25.08 10.40 208 206439 32991 56052429
Meconium in amniotic fluid 25.07 10.40 14 206633 236 56085184
Protein C increased 24.92 10.40 11 206636 108 56085312
Morbid thoughts 24.83 10.40 19 206628 557 56084863
Haemophagocytic lymphohistiocytosis 24.76 10.40 3 206644 9569 56075851
Therapeutic product ineffective 24.74 10.40 28 206619 1364 56084056
Colon cancer 24.72 10.40 3 206644 9558 56075862
White blood cell count decreased 24.69 10.40 320 206327 125670 55959750
Congenital hearing disorder 24.64 10.40 7 206640 14 56085406
Physical assault 24.59 10.40 23 206624 893 56084527
Gastritis 24.56 10.40 57 206590 34645 56050775
Hypoglycaemia neonatal 24.48 10.40 23 206624 898 56084522
Chorea 24.41 10.40 28 206619 1384 56084036
Cervix neoplasm 24.21 10.40 13 206634 202 56085218
Device difficult to use 24.17 10.40 5 206642 10756 56074664
Merycism 24.15 10.40 13 206634 203 56085217
Ear pain 24.14 10.40 48 206599 30842 56054578
Small for dates baby 23.98 10.40 45 206602 3485 56081935
Ventricular tachycardia 23.92 10.40 124 206523 16777 56068643
Blood glucose increased 23.78 10.40 398 206249 74753 56010667
Pallor 23.73 10.40 161 206486 23988 56061432
Tendonitis 23.66 10.40 19 206628 18078 56067342
Amylase increased 23.65 10.40 60 206587 5711 56079709
Paralysis 23.63 10.40 80 206567 8952 56076468
Device stimulation issue 23.52 10.40 9 206638 59 56085361
Skin necrosis 23.50 10.40 8 206639 12353 56073067
Ventricular arrhythmia 23.43 10.40 44 206603 3410 56082010
Cerebrovascular accident 23.39 10.40 242 206405 99028 55986392
Hospitalisation 23.39 10.40 170 206477 74830 56010590
Eosinopenia 23.38 10.40 8 206639 36 56085384
Wrong patient received product 23.30 10.40 34 206613 2137 56083283
Uveitis 23.24 10.40 6 206641 11089 56074331
Movement disorder 23.24 10.40 135 206512 19063 56066357
Idiopathic intracranial hypertension 23.17 10.40 37 206610 2517 56082903
Diverticulum 23.15 10.40 6 206641 11060 56074360
Tremor neonatal 23.14 10.40 11 206636 130 56085290
Decreased bronchial secretion 23.14 10.40 9 206638 62 56085358
Haemorrhoids 23.10 10.40 24 206623 20182 56065238
Pericarditis 23.09 10.40 272 206375 108651 55976769
Diabetes insipidus 23.07 10.40 36 206611 2401 56083019
Staphylococcal parotitis 23.06 10.40 5 206642 0 56085420
On and off phenomenon 22.84 10.40 29 206618 1595 56083825
Drug screen false positive 22.80 10.40 21 206626 799 56084621
Pressure of speech 22.80 10.40 18 206629 553 56084867
Neuropsychiatric symptoms 22.78 10.40 19 206628 632 56084788
Frontotemporal dementia 22.76 10.40 15 206632 345 56085075
Food craving 22.76 10.40 28 206619 1491 56083929
Neurodegenerative disorder 22.74 10.40 14 206633 285 56085135
Post-traumatic stress disorder 22.73 10.40 51 206596 4487 56080933
Blister 22.67 10.40 273 206374 108614 55976806
Candida infection 22.65 10.40 37 206610 25630 56059790
Pulmonary mass 22.64 10.40 25 206622 20445 56064975
Aplastic anaemia 22.60 10.40 3 206644 8925 56076495
Osteopenia 22.54 10.40 20 206627 18121 56067299
Muscle spasticity 22.49 10.40 24 206623 19936 56065484
Dependence 22.49 10.40 32 206615 1965 56083455
Neonatal respiratory distress syndrome 22.43 10.40 38 206609 2716 56082704
Clostridium difficile infection 22.36 10.40 41 206606 27157 56058263
Seasonal allergy 22.32 10.40 18 206629 17090 56068330
Dysphonia 22.27 10.40 79 206568 41868 56043552
Dehydration 22.18 10.40 430 206217 158395 55927025
Selective eating disorder 22.17 10.40 31 206616 1873 56083547
Troponin increased 22.16 10.40 76 206571 8559 56076861
Aphasia 22.15 10.40 189 206458 30226 56055194
Transfusion 22.06 10.40 11 206636 13509 56071911
Upper-airway cough syndrome 22.01 10.40 4 206643 9434 56075986
Bipolar II disorder 21.95 10.40 14 206633 304 56085116
Suppressed lactation 21.92 10.40 16 206631 436 56084984
Starvation ketoacidosis 21.88 10.40 9 206638 73 56085347
Eczema 21.88 10.40 39 206608 26114 56059306
Electrocardiogram QT interval abnormal 21.82 10.40 11 206636 149 56085271
Depressive delusion 21.82 10.40 6 206641 10 56085410
Spasmodic dysphonia 21.67 10.40 9 206638 75 56085345
Generalised anxiety disorder 21.67 10.40 31 206616 1913 56083507
Flatulence 21.66 10.40 52 206595 31236 56054184
Agranulocytosis 21.63 10.40 150 206497 22509 56062911
Feelings of worthlessness 21.47 10.40 14 206633 316 56085104
Vitamin K decreased 21.46 10.40 6 206641 11 56085409
Bladder dilatation 21.46 10.40 20 206627 773 56084647
Alcoholism 21.43 10.40 33 206614 2176 56083244
Negative thoughts 21.42 10.40 21 206626 865 56084555
Pupillary light reflex tests abnormal 21.31 10.40 11 206636 157 56085263
Hyperkalaemia 21.30 10.40 105 206542 50760 56034660
Tuberculosis 21.20 10.40 7 206640 11022 56074398
Epilepsy 21.20 10.40 162 206485 25069 56060351
Injection site warmth 21.20 10.40 13 206634 14230 56071190
Tubulointerstitial nephritis 21.16 10.40 18 206629 16647 56068773
Neonatal hypotension 21.12 10.40 10 206637 117 56085303
Hyporesponsive to stimuli 21.10 10.40 22 206625 976 56084444
Insomnia 21.04 10.40 883 205764 190977 55894443
Hot flush 21.01 10.40 94 206553 46632 56038788
Sleep disorder due to a general medical condition 20.89 10.40 4 206643 9086 56076334
Haematotoxicity 20.79 10.40 3 206644 8380 56077040
Chronic sinusitis 20.78 10.40 3 206644 8375 56077045
Skin reaction 20.76 10.40 11 206636 13052 56072368
Angioedema 20.75 10.40 80 206567 41373 56044047
Electrocardiogram T wave inversion 20.73 10.40 41 206606 3302 56082118
Sudden death 20.71 10.40 80 206567 9545 56075875
Dysphagia 20.69 10.40 419 206228 81528 56003892
Burning sensation 20.69 10.40 100 206547 48596 56036824
Angina pectoris 20.58 10.40 45 206602 27931 56057489
Constipation 20.56 10.40 574 206073 201369 55884051
Hypocalcaemia 20.55 10.40 47 206600 28713 56056707
Tongue spasm 20.46 10.40 8 206639 56 56085364
Dysgeusia 20.45 10.40 79 206568 40836 56044584
Bronchopulmonary aspergillosis 20.40 10.40 3 206644 8261 56077159
Grandiosity 20.31 10.40 13 206634 284 56085136
Musculoskeletal discomfort 20.27 10.40 18 206629 16300 56069120
Product quality issue 20.23 10.40 55 206592 31681 56053739
Stoma site hypergranulation 20.19 10.40 13 206634 287 56085133
Breast engorgement 20.16 10.40 9 206638 91 56085329
Haemoptysis 20.14 10.40 42 206605 26518 56058902
Parasomnia 20.04 10.40 15 206632 425 56084995
Status epilepticus 20.00 10.40 109 206538 15032 56070388
Pulmonary artery stenosis congenital 19.95 10.40 12 206635 234 56085186
Labelled drug-food interaction medication error 19.93 10.40 10 206637 134 56085286
Anterior displaced anus 19.93 10.40 6 206641 16 56085404
Skin exfoliation 19.93 10.40 69 206578 36831 56048589
Disturbance in sexual arousal 19.91 10.40 9 206638 94 56085326
Infusion site pain 19.88 10.40 13 206634 13749 56071671
Eye movement disorder 19.85 10.40 50 206597 4739 56080681
Muscular weakness 19.84 10.40 267 206380 104185 55981235
Abulia 19.80 10.40 15 206632 433 56084987
Product storage error 19.75 10.40 12 206635 13201 56072219
Somatic symptom disorder of pregnancy 19.74 10.40 9 206638 96 56085324
Schizoaffective disorder bipolar type 19.67 10.40 10 206637 138 56085282
Faeces discoloured 19.64 10.40 20 206627 16976 56068444
Metastases to central nervous system 19.61 10.40 10 206637 12126 56073294
Drug use disorder 19.61 10.40 49 206598 4620 56080800
Sense of a foreshortened future 19.61 10.40 5 206642 5 56085415
Hypoacusis 19.56 10.40 31 206616 21737 56063683
Urinary incontinence 19.56 10.40 180 206467 29405 56056015
Teratoma benign 19.44 10.40 8 206639 65 56085355
Pulmonary embolism 19.42 10.40 523 206124 106601 55978819
Red blood cell count decreased 19.42 10.40 69 206578 36548 56048872
Maternal exposure during breast feeding 19.41 10.40 42 206605 3605 56081815
Job dissatisfaction 19.39 10.40 7 206640 38 56085382
Lip dry 19.39 10.40 79 206568 9661 56075759
Compartment syndrome 19.30 10.40 30 206617 1994 56083426
Distal intestinal obstruction syndrome 19.29 10.40 14 206633 378 56085042
Chronic kidney disease 19.27 10.40 84 206563 41972 56043448
Hyponatraemia 19.19 10.40 501 206146 101638 55983782
Fear of weight gain 19.17 10.40 6 206641 19 56085401
Atrial septal defect 19.16 10.40 60 206587 6446 56078974
Blepharospasm 19.09 10.40 40 206607 3358 56082062
Systemic lupus erythematosus 19.07 10.40 509 206138 179569 55905851
Resting tremor 19.05 10.40 18 206629 708 56084712
Eye haemorrhage 19.02 10.40 3 206644 7844 56077576
Gastroenteritis 19.02 10.40 38 206609 24374 56061046
Delusional disorder, unspecified type 19.01 10.40 14 206633 387 56085033
Pneumothorax 18.95 10.40 16 206631 14851 56070569
Lymphocyte count decreased 18.90 10.40 47 206600 27892 56057528
Device related infection 18.88 10.40 32 206615 21848 56063572
False positive investigation result 18.84 10.40 16 206631 546 56084874
Tooth infection 18.82 10.40 18 206629 15734 56069686
Atelectasis 18.81 10.40 26 206621 19282 56066138
Lacrimation increased 18.59 10.40 24 206623 18324 56067096
Sluggishness 18.58 10.40 48 206599 4620 56080800
Unevaluable event 18.52 10.40 101 206546 47586 56037834
Psychogenic tremor 18.50 10.40 6 206641 22 56085398
Dry mouth 18.50 10.40 335 206312 63870 56021550
Dermatitis 18.49 10.40 17 206630 15140 56070280
C-reactive protein increased 18.46 10.40 192 206455 78492 56006928
Child abuse 18.44 10.40 4 206643 0 56085420
Convulsive threshold lowered 18.41 10.40 13 206634 336 56085084
Gout 18.40 10.40 11 206636 12210 56073210
Binge eating 18.40 10.40 14 206633 407 56085013
Radial nerve palsy 18.37 10.40 15 206632 484 56084936
Bradycardia neonatal 18.31 10.40 19 206628 838 56084582
Increased appetite 18.31 10.40 72 206575 8663 56076757
Migraine 18.30 10.40 217 206430 86580 55998840
Megacolon 18.18 10.40 27 206620 1724 56083696
Aortic bruit 18.10 10.40 6 206641 24 56085396
Vestibular migraine 18.08 10.40 11 206636 219 56085201
Delusional perception 18.08 10.40 11 206636 219 56085201
Bone erosion 18.02 10.40 17 206630 14957 56070463
Antipsychotic drug level below therapeutic 18.02 10.40 12 206635 281 56085139
Respiratory disorder 18.00 10.40 64 206583 33893 56051527
Dementia with Lewy bodies 17.98 10.40 12 206635 282 56085138
Defect conduction intraventricular 17.98 10.40 9 206638 120 56085300
Spinal stenosis 17.96 10.40 15 206632 13999 56071421
Ankylosing spondylitis 17.90 10.40 7 206640 9923 56075497
Dysuria 17.88 10.40 182 206465 30547 56054873
Blood pressure systolic increased 17.85 10.40 83 206564 40753 56044667
Trismus 17.83 10.40 40 206607 3518 56081902
Progressive multifocal leukoencephalopathy 17.83 10.40 11 206636 12002 56073418
Proteinuria 17.79 10.40 23 206624 17547 56067873
Lymphoma 17.76 10.40 8 206639 10420 56075000
Cerebellar atrophy 17.73 10.40 17 206630 681 56084739
Post procedural haemorrhage 17.72 10.40 3 206644 7446 56077974
Ageusia 17.66 10.40 12 206635 12439 56072981
Crying 17.65 10.40 137 206510 21303 56064117
Metastases to lymph nodes 17.63 10.40 3 206644 7420 56078000
Confabulation 17.62 10.40 12 206635 292 56085128
Resuscitation 17.62 10.40 21 206626 1082 56084338
Enthesopathy 17.60 10.40 4 206643 8059 56077361
Tongue movement disturbance 17.58 10.40 12 206635 293 56085127
Head titubation 17.55 10.40 18 206629 783 56084637
Cataract 17.54 10.40 113 206534 51134 56034286
Ballismus 17.49 10.40 8 206639 86 56085334
Chronic obstructive pulmonary disease 17.49 10.40 131 206516 57284 56028136
Inappropriate antidiuretic hormone secretion 17.48 10.40 98 206549 13658 56071762
Bronchospasm 17.48 10.40 19 206628 15650 56069770
Bruxism 17.47 10.40 37 206610 3129 56082291
Sleep disorder 17.42 10.40 347 206300 67316 56018104
Nystagmus 17.41 10.40 54 206593 5771 56079649
Haematochezia 17.31 10.40 92 206555 43626 56041794
Respiratory tract congestion 17.29 10.40 19 206628 15572 56069848
Patient uncooperative 17.23 10.40 10 206637 182 56085238
Eye irritation 17.19 10.40 27 206620 19001 56066419
C-reactive protein abnormal 17.19 10.40 73 206574 36736 56048684
Ejection fraction decreased 17.13 10.40 29 206618 19812 56065608
Carpal tunnel syndrome 17.11 10.40 25 206622 18119 56067301
No adverse event 17.07 10.40 72 206575 36302 56049118
Syncope 17.05 10.40 519 206128 107680 55977740
Ileus 17.05 10.40 98 206549 13784 56071636
Pancreatic carcinoma 17.04 10.40 3 206644 7238 56078182
Rash maculo-papular 17.03 10.40 52 206595 28855 56056565
Poverty of speech 17.03 10.40 12 206635 309 56085111
Psychotic symptom 17.01 10.40 23 206624 1346 56084074
Compulsive sexual behaviour 17.00 10.40 7 206640 57 56085363
Ventricular extrasystoles 16.97 10.40 82 206565 10788 56074632
Acidosis 16.96 10.40 80 206567 10421 56074999
Central obesity 16.90 10.40 21 206626 1130 56084290
Pulmonary oedema 16.89 10.40 114 206533 51029 56034391
Gastric ulcer 16.84 10.40 36 206611 22527 56062893
Type 1 diabetes mellitus 16.84 10.40 38 206609 3356 56082064
Upper limb fracture 16.81 10.40 23 206624 17132 56068288
Pneumonia viral 16.77 10.40 3 206644 7155 56078265
Antisocial behaviour 16.70 10.40 12 206635 319 56085101
Blood cholesterol increased 16.67 10.40 366 206281 72213 56013207
Somatic delusion 16.59 10.40 15 206632 557 56084863
Gait deviation 16.49 10.40 7 206640 62 56085358
Pulseless electrical activity 16.46 10.40 60 206587 6964 56078456
Drug reaction with eosinophilia and systemic symptoms 16.46 10.40 177 206470 30127 56055293
Post procedural complication 16.39 10.40 20 206627 15646 56069774
Lung neoplasm malignant 16.38 10.40 24 206623 17372 56068048
Dropped head syndrome 16.36 10.40 8 206639 101 56085319
Diffuse large B-cell lymphoma 16.31 10.40 3 206644 7013 56078407
Haematuria 16.29 10.40 48 206599 26939 56058481
Deafness 16.28 10.40 22 206625 16472 56068948
Sudden cardiac death 16.28 10.40 28 206619 2026 56083394
Reduced facial expression 16.27 10.40 26 206621 1770 56083650
Somatic hallucination 16.22 10.40 4 206643 3 56085417
Acute generalised exanthematous pustulosis 16.15 10.40 8 206639 9861 56075559
Breast discharge 16.13 10.40 18 206629 863 56084557
Screaming 16.06 10.40 35 206612 3019 56082401
Pupil fixed 16.05 10.40 25 206622 1665 56083755
Suspiciousness 16.01 10.40 12 206635 341 56085079
Perinatal depression 16.00 10.40 15 206632 584 56084836
Joint injury 15.95 10.40 45 206602 25609 56059811
Colitis ischaemic 15.94 10.40 76 206571 9944 56075476
Electrocardiogram ST segment elevation 15.94 10.40 39 206608 3630 56081790
Neuralgia 15.92 10.40 40 206607 23655 56061765
Hostility 15.90 10.40 26 206621 1805 56083615
Haematoma 15.89 10.40 62 206585 31957 56053463
Intervertebral disc protrusion 15.87 10.40 35 206612 21659 56063761
Creatinine renal clearance decreased 15.86 10.40 18 206629 14541 56070879
Skin infection 15.86 10.40 15 206632 13180 56072240
Postmortem blood drug level abnormal 15.83 10.40 12 206635 347 56085073
Freezing phenomenon 15.79 10.40 20 206627 1097 56084323
Diabetic ketoacidosis 15.76 10.40 121 206526 18750 56066670
Lymphadenopathy 15.72 10.40 71 206576 35137 56050283
Taste disorder 15.71 10.40 8 206639 9707 56075713
Spinal compression fracture 15.70 10.40 15 206632 13119 56072301
Indifference 15.70 10.40 8 206639 111 56085309
Haemorrhage 15.64 10.40 132 206515 56265 56029155
Complication associated with device 15.64 10.40 20 206627 15330 56070090
Joint effusion 15.61 10.40 19 206628 14879 56070541
Ileus paralytic 15.54 10.40 42 206605 4153 56081267
Abdominal pain lower 15.50 10.40 39 206608 23053 56062367
Labelled drug-food interaction issue 15.49 10.40 5 206642 18 56085402
Tachypnoea 15.24 10.40 103 206544 15327 56070093
Gestational hypertension 15.24 10.40 29 206618 2270 56083150
Abnormal dreams 15.21 10.40 73 206574 9576 56075844
Swelling face 15.20 10.40 132 206515 55937 56029483
Induced abortion failed 15.14 10.40 10 206637 231 56085189
Spinal fracture 15.13 10.40 23 206624 16401 56069019
Initial insomnia 15.11 10.40 50 206597 5529 56079891
Neurological decompensation 15.10 10.40 30 206617 2424 56082996
Echolalia 15.03 10.40 9 206638 174 56085246
Hepatic enzyme increased 15.01 10.40 497 206150 170887 55914533
Nail disorder 15.00 10.40 12 206635 11439 56073981
Facial spasm 14.98 10.40 15 206632 634 56084786
Hypoglycaemia 14.97 10.40 288 206359 55527 56029893
Multiple sclerosis relapse 14.87 10.40 100 206547 44803 56040617
Hallucination, olfactory 14.84 10.40 10 206637 239 56085181
Cortisol increased 14.84 10.40 12 206635 382 56085038
Post procedural infection 14.82 10.40 6 206641 8326 56077094
Pseudobulbar palsy 14.80 10.40 4 206643 6 56085414
Panic disorder 14.79 10.40 30 206617 2461 56082959
Large for dates baby 14.77 10.40 13 206634 466 56084954
Malignant polyp 14.72 10.40 9 206638 181 56085239
Bone marrow eosinophilic leukocyte count increased 14.70 10.40 5 206642 22 56085398
Irregular sleep phase 14.70 10.40 5 206642 22 56085398
Fear of injection 14.69 10.40 3 206644 6512 56078908
Obsessive-compulsive symptom 14.63 10.40 7 206640 84 56085336
Soliloquy 14.59 10.40 9 206638 184 56085236
Postoperative wound infection 14.57 10.40 8 206639 9305 56076115
Pulmonary fibrosis 14.53 10.40 58 206589 29700 56055720
Injection site haemorrhage 14.51 10.40 38 206609 22163 56063257
Bradycardia foetal 14.44 10.40 12 206635 397 56085023
Cardiotoxicity 14.40 10.40 61 206586 7589 56077831
Rash erythematous 14.36 10.40 79 206568 37142 56048278
Acute myocardial infarction 14.36 10.40 60 206587 30333 56055087
Postmortem blood drug level 14.32 10.40 8 206639 135 56085285
Antipsychotic drug level above therapeutic 14.28 10.40 18 206629 983 56084437
Agitation neonatal 14.22 10.40 13 206634 490 56084930
Floppy infant 14.21 10.40 7 206640 90 56085330
Amimia 14.15 10.40 6 206641 53 56085367
Feeling jittery 14.12 10.40 84 206563 11962 56073458
Pathological fracture 14.10 10.40 6 206641 8083 56077337
Neonatal behavioural syndrome 14.05 10.40 6 206641 54 56085366
Dissociative amnesia 14.03 10.40 5 206642 26 56085394
Eye pruritus 13.97 10.40 19 206628 14187 56071233
Peripheral circulatory failure 13.96 10.40 17 206630 896 56084524
Neonatal hypoxia 13.93 10.40 13 206634 503 56084917
Central nervous system injury 13.91 10.40 8 206639 143 56085277
Pseudomonas infection 13.90 10.40 10 206637 10061 56075359
Tongue paralysis 13.89 10.40 9 206638 201 56085219
Buccoglossal syndrome 13.83 10.40 3 206644 0 56085420
Lymphoedema 13.83 10.40 11 206636 10519 56074901
Erotomanic delusion 13.83 10.40 3 206644 0 56085420
Diabetic cardiomyopathy 13.83 10.40 3 206644 0 56085420
Hypothermia neonatal 13.83 10.40 3 206644 0 56085420
Micrographia 13.83 10.40 3 206644 0 56085420
Tricuspid valve incompetence 13.78 10.40 17 206630 13236 56072184
Drug diversion 13.76 10.40 16 206631 803 56084617
Tooth abscess 13.74 10.40 18 206629 13657 56071763
Immunosuppression 13.74 10.40 6 206641 7958 56077462
Allergic hepatitis 13.72 10.40 5 206642 28 56085392
Genital labial adhesions 13.72 10.40 5 206642 28 56085392
Immobilisation prolonged 13.68 10.40 7 206640 98 56085322
Skin disorder 13.67 10.40 50 206597 26259 56059161
Skull fracture 13.62 10.40 17 206630 919 56084501
Oral herpes 13.61 10.40 41 206606 22849 56062571
Peripheral venous disease 13.61 10.40 73 206574 10006 56075414
Lactation disorder 13.61 10.40 11 206636 350 56085070
Delusional disorder, erotomanic type 13.58 10.40 5 206642 29 56085391
Thrombotic thrombocytopenic purpura 13.56 10.40 37 206610 3680 56081740
Nerve injury 13.52 10.40 8 206639 8929 56076491
Hyperinsulinaemia 13.49 10.40 7 206640 101 56085319
Blood creatinine increased 13.47 10.40 210 206437 79981 56005439
Leukopenia neonatal 13.44 10.40 5 206642 30 56085390
Ovarian germ cell cancer stage II 13.44 10.40 5 206642 30 56085390
Retrograde amnesia 13.43 10.40 12 206635 439 56084981
Bladder prolapse 13.42 10.40 25 206622 1926 56083494
Electroconvulsive therapy 13.41 10.40 6 206641 61 56085359
Bundle branch block 13.40 10.40 16 206631 826 56084594
Therapy cessation 13.40 10.40 53 206594 27211 56058209
Diabetic hyperosmolar coma 13.39 10.40 11 206636 358 56085062
Lack of spontaneous speech 13.34 10.40 8 206639 155 56085265
Blood iron decreased 13.34 10.40 16 206631 12611 56072809
Drowning 13.31 10.40 12 206635 444 56084976
Duplicate therapy error 13.24 10.40 6 206641 63 56085357
Rotator cuff syndrome 13.24 10.40 15 206632 12128 56073292
Tearfulness 13.24 10.40 37 206610 3731 56081689
Pre-eclampsia 13.24 10.40 64 206583 8422 56076998
Posterior reversible encephalopathy syndrome 13.17 10.40 24 206623 15936 56069484
Pathogen resistance 13.05 10.40 3 206644 5997 56079423
Breast enlargement 13.03 10.40 21 206626 1440 56083980
Tooth disorder 12.99 10.40 49 206598 25504 56059916
Duodenal ulcer 12.97 10.40 5 206642 7150 56078270
Anal sphincter atony 12.97 10.40 9 206638 226 56085194
Hypoaesthesia oral 12.95 10.40 79 206568 11352 56074068
Diabetic complication 12.93 10.40 16 206631 857 56084563
Encopresis 12.91 10.40 7 206640 111 56085309
Synovial cyst 12.91 10.40 9 206638 9205 56076215
Arthritis infective 12.91 10.40 3 206644 5953 56079467
Agitated depression 12.90 10.40 8 206639 165 56085255
Rectal prolapse 12.87 10.40 24 206623 1850 56083570
Blood sodium decreased 12.86 10.40 132 206515 22202 56063218
Autonomic nervous system imbalance 12.83 10.40 29 206618 2564 56082856
Personality disorder 12.82 10.40 45 206602 5128 56080292
Discoloured vomit 12.81 10.40 15 206632 758 56084662
Illusion 12.81 10.40 17 206630 977 56084443
Therapeutic response changed 12.79 10.40 16 206631 867 56084553
Jealous delusion 12.79 10.40 5 206642 35 56085385
Dopamine dysregulation syndrome 12.78 10.40 8 206639 168 56085252
Infective pulmonary exacerbation of cystic fibrosis 12.77 10.40 7 206640 8150 56077270
Dysphoria 12.76 10.40 43 206604 4799 56080621
Brain oedema 12.76 10.40 88 206559 13183 56072237
Flight of ideas 12.74 10.40 11 206636 384 56085036
Toxic epidermal necrolysis 12.74 10.40 40 206607 22002 56063418
Bronchial aspiration procedure 12.74 10.40 8 206639 169 56085251
Hygroma colli 12.70 10.40 4 206643 13 56085407
Mitral valve incompetence 12.70 10.40 30 206617 18123 56067297
Neurological examination abnormal 12.70 10.40 9 206638 234 56085186
Psychotic disorder due to a general medical condition 12.70 10.40 9 206638 234 56085186
Electroencephalogram abnormal 12.68 10.40 35 206612 3504 56081916
Cyst 12.66 10.40 17 206630 12761 56072659
Influenza like illness 12.65 10.40 153 206494 60835 56024585
Encephalopathy 12.65 10.40 191 206456 35134 56050286
Dry eye 12.61 10.40 78 206569 35638 56049782
Brain hypoxia 12.53 10.40 12 206635 480 56084940
Impaired self-care 12.52 10.40 23 206624 1753 56083667
Swollen tongue 12.47 10.40 168 206479 30156 56055264
Patella fracture 12.41 10.40 24 206623 1901 56083519
Reflexes abnormal 12.41 10.40 13 206634 580 56084840
Peripheral sensory neuropathy 12.38 10.40 5 206642 6951 56078469
Asphyxia 12.36 10.40 48 206599 5741 56079679
Angle closure glaucoma 12.36 10.40 25 206622 2046 56083374
Depression suicidal 12.36 10.40 22 206625 1636 56083784
Neutrophil count decreased 12.33 10.40 120 206527 49702 56035718
Dysmetropsia 12.33 10.40 6 206641 75 56085345
Live birth 12.32 10.40 118 206529 19487 56065933
Dyslipidaemia 12.23 10.40 51 206596 6302 56079118
Enteritis 12.23 10.40 6 206641 7437 56077983
Rebound psychosis 12.22 10.40 5 206642 40 56085380
Anhedonia 12.18 10.40 70 206577 9844 56075576
Escherichia infection 12.17 10.40 15 206632 11684 56073736
Pulse absent 12.13 10.40 43 206604 4924 56080496
Poriomania 12.12 10.40 6 206641 78 56085342
Lung perforation 12.12 10.40 6 206641 78 56085342
Oesophageal food impaction 12.10 10.40 8 206639 185 56085235
Malignant catatonia 12.10 10.40 8 206639 185 56085235
Unintentional medical device removal 12.08 10.40 3 206644 5691 56079729
Metabolic alkalosis 12.06 10.40 30 206617 2821 56082599
Diet noncompliance 12.06 10.40 10 206637 330 56085090
Immune reconstitution inflammatory syndrome 12.02 10.40 3 206644 5671 56079749
Spinal disorder 12.01 10.40 9 206638 8869 56076551
Water intoxication 12 10.40 11 206636 416 56085004
Polyhydramnios 12.00 10.40 25 206622 2090 56083330
Cardiac failure acute 12.00 10.40 9 206638 8864 56076556
Limbic encephalitis 11.94 10.40 9 206638 258 56085162
Helicobacter infection 11.92 10.40 193 206454 73075 56012345
Ovarian cancer 11.92 10.40 4 206643 6234 56079186
Sleep talking 11.90 10.40 16 206631 931 56084489
Pulmonary haemorrhage 11.87 10.40 5 206642 6778 56078642
Oscillopsia 11.84 10.40 7 206640 132 56085288
Skin lesion 11.82 10.40 58 206589 28077 56057343
Female sexual dysfunction 11.81 10.40 5 206642 44 56085376
Generalised oedema 11.80 10.40 22 206625 14479 56070941
Congenital emphysema 11.76 10.40 3 206644 3 56085417
Electrolyte substitution therapy 11.76 10.40 3 206644 3 56085417
Asterixis 11.73 10.40 18 206629 1183 56084237
Electrocardiogram change 11.72 10.40 13 206634 619 56084801
Device issue 11.71 10.40 39 206608 21067 56064353
Polyarthritis 11.61 10.40 9 206638 8719 56076701
Burnout syndrome 11.59 10.40 8 206639 199 56085221
Splenic injury 11.56 10.40 8 206639 200 56085220
Blood magnesium decreased 11.56 10.40 16 206631 11858 56073562
Acinetobacter bacteraemia 11.54 10.40 6 206641 87 56085333
Ketoacidosis 11.47 10.40 37 206610 4038 56081382
Infusion site erythema 11.45 10.40 11 206636 9595 56075825
Congestive cardiomyopathy 11.43 10.40 47 206600 5772 56079648
Cardiopulmonary failure 11.42 10.40 33 206614 3392 56082028
Insulin resistance 11.42 10.40 14 206633 743 56084677
Multiple allergies 11.41 10.40 13 206634 10483 56074937
Blood sodium increased 11.40 10.40 27 206620 2461 56082959
Lactate pyruvate ratio increased 11.36 10.40 6 206641 90 56085330
Injury 11.36 10.40 294 206353 59557 56025863
Muscle contractions involuntary 11.35 10.40 24 206623 2027 56083393
Compulsions 11.35 10.40 8 206639 206 56085214
Kidney duplex 11.34 10.40 5 206642 49 56085371
Accommodation disorder 11.28 10.40 10 206637 362 56085058
Squamous cell carcinoma of skin 11.17 10.40 3 206644 5399 56080021
Cardiac disorder 11.16 10.40 111 206536 45776 56039644
Infantile apnoea 11.12 10.40 15 206632 876 56084544
Hypernatraemia 11.11 10.40 51 206596 6569 56078851
Arthritis bacterial 11.09 10.40 4 206643 5957 56079463
Wrong patient 11.06 10.40 7 206640 150 56085270
Blood osmolarity decreased 11.05 10.40 15 206632 881 56084539
Pneumonia bacterial 11.04 10.40 8 206639 8020 56077400
Sacroiliac joint dysfunction 11.04 10.40 4 206643 22 56085398
Device malfunction 11.02 10.40 27 206620 16109 56069311
Somatic symptom disorder 11.00 10.40 24 206623 2071 56083349
Pyroglutamic acidosis 10.99 10.40 11 206636 465 56084955
Respiratory alkalosis 10.96 10.40 27 206620 2524 56082896
Crepitations 10.93 10.40 6 206641 6978 56078442
Withdrawal catatonia 10.91 10.40 5 206642 54 56085366
Housebound 10.90 10.40 8 206639 220 56085200
Libido decreased 10.89 10.40 26 206621 2382 56083038
Foetal chromosome abnormality 10.89 10.40 4 206643 23 56085397
Mass 10.87 10.40 19 206628 12820 56072600
Parkinsonian rest tremor 10.86 10.40 6 206641 99 56085321
Cellulitis orbital 10.85 10.40 11 206636 472 56084948
Stoma site erythema 10.84 10.40 16 206631 1016 56084404
Diet refusal 10.81 10.40 12 206635 572 56084848
White blood cell count abnormal 10.80 10.40 4 206643 5863 56079557
Groin pain 10.78 10.40 11 206636 9329 56076091
Cholecystitis acute 10.72 10.40 7 206640 7409 56078011
Kussmaul respiration 10.71 10.40 8 206639 226 56085194
Muscle strength abnormal 10.68 10.40 5 206642 57 56085363
Hangover 10.66 10.40 19 206628 1414 56084006
Suicide threat 10.61 10.40 4 206643 25 56085395
Ultrasound abdomen abnormal 10.60 10.40 5 206642 58 56085362
Ideas of reference 10.60 10.40 6 206641 104 56085316
Faecal vomiting 10.60 10.40 12 206635 585 56084835
Exaggerated startle response 10.56 10.40 3 206644 6 56085414
Fibula agenesis 10.56 10.40 3 206644 6 56085414
Macroprolactinaemia 10.56 10.40 3 206644 6 56085414
Atrophy of globe 10.56 10.40 3 206644 6 56085414
Wound healing normal 10.56 10.40 3 206644 6 56085414
Libido increased 10.55 10.40 18 206629 1294 56084126
Blood citric acid increased 10.52 10.40 5 206642 59 56085361
Snoring 10.52 10.40 33 206614 3548 56081872
Accelerated hypertension 10.51 10.40 10 206637 397 56085023
Blood potassium decreased 10.50 10.40 91 206556 38581 56046839
Invasive ductal breast carcinoma 10.48 10.40 6 206641 6820 56078600
Breast cancer stage II 10.48 10.40 4 206643 5754 56079666
Angina unstable 10.47 10.40 6 206641 6815 56078605
Device dislocation 10.45 10.40 45 206602 22561 56062859
Intervertebral disc degeneration 10.42 10.40 23 206624 14231 56071189

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1732.53 11.76 2011 129401 89503 31476429
Neuroleptic malignant syndrome 1577.83 11.76 941 130471 15928 31550004
Toxicity to various agents 1427.29 11.76 2630 128782 178857 31387075
Suicide attempt 1287.06 11.76 1135 130277 36113 31529819
Sopor 1139.12 11.76 667 130745 10885 31555047
Drug interaction 1033.66 11.76 2504 128908 206039 31359893
Drug abuse 905.14 11.76 1437 129975 86321 31479611
Intentional overdose 870.36 11.76 962 130450 40427 31525505
Overdose 780.39 11.76 1318 130094 83346 31482586
Depression 775.93 11.76 1367 130045 89448 31476484
Psychotic disorder 715.41 11.76 652 130760 21641 31544291
Sedation 703.08 11.76 602 130810 18363 31547569
Agitation 689.15 11.76 979 130433 53190 31512742
Aggression 658.05 11.76 792 130620 36499 31529433
Somnolence 581.87 11.76 1277 130135 98168 31467764
Extrapyramidal disorder 557.01 11.76 431 130981 11347 31554585
Tardive dyskinesia 532.11 11.76 315 131097 5244 31560688
Dyskinesia 509.79 11.76 526 130886 20384 31545548
Dystonia 489.68 11.76 377 131035 9848 31556084
Coma 488.50 11.76 720 130692 40430 31525502
Priapism 482.42 11.76 277 131135 4343 31561589
Hallucination 470.78 11.76 755 130657 45655 31520277
Intentional self-injury 459.79 11.76 406 131006 12909 31553023
Diarrhoea 445.97 11.76 484 130928 351925 31214007
Depressed level of consciousness 424.80 11.76 652 130760 37949 31527983
Akathisia 420.43 11.76 300 131112 6953 31558979
Delusion 406.64 11.76 362 131050 11635 31554297
Schizophrenia 397.63 11.76 342 131070 10488 31555444
Paranoia 378.78 11.76 329 131083 10226 31555706
Electrocardiogram QT prolonged 351.44 11.76 593 130819 37394 31528538
Suicidal ideation 340.35 11.76 571 130841 35835 31530097
Mania 327.18 11.76 285 131127 8892 31557040
Dyspnoea 323.98 11.76 582 130830 342897 31223035
Muscle rigidity 306.69 11.76 284 131128 9613 31556319
Catatonia 304.33 11.76 210 131202 4604 31561328
Restlessness 297.84 11.76 423 130989 22938 31542994
Diabetes mellitus 283.74 11.76 577 130835 41979 31523953
Delirium 281.39 11.76 566 130846 40855 31525077
Febrile neutropenia 271.14 11.76 84 131328 121765 31444167
Hallucination, auditory 253.10 11.76 261 131151 10099 31555833
Serotonin syndrome 248.31 11.76 346 131066 18427 31547505
Abnormal behaviour 244.65 11.76 390 131022 23438 31542494
Parkinsonism 244.14 11.76 223 131189 7413 31558519
Oculogyric crisis 235.99 11.76 117 131295 1338 31564594
Confusional state 234.90 11.76 1134 130278 132200 31433732
Arthralgia 232.59 11.76 173 131239 151251 31414681
Bradyphrenia 232.12 11.76 172 131240 4232 31561700
Pneumonia 230.92 11.76 673 130739 334639 31231293
Nausea 219.36 11.76 608 130804 307339 31258593
Fatigue 219.19 11.76 689 130723 334517 31231415
Blood creatine phosphokinase increased 214.99 11.76 512 130900 41462 31524470
Psychomotor hyperactivity 212.17 11.76 220 131192 8567 31557365
Anaemia 210.62 11.76 351 131061 213171 31352761
Rash 207.38 11.76 322 131090 201164 31364768
Obsessive-compulsive disorder 206.21 11.76 168 131244 4769 31561163
Intentional product misuse 205.35 11.76 473 130939 37478 31528454
Malignant neoplasm progression 201.63 11.76 41 131371 78957 31486975
Poisoning deliberate 197.67 11.76 195 131217 7149 31558783
Drug withdrawal syndrome neonatal 189.94 11.76 139 131273 3353 31562579
Foetal exposure during pregnancy 189.58 11.76 480 130932 40396 31525536
Altered state of consciousness 184.55 11.76 321 131091 20730 31545202
Disease progression 178.07 11.76 76 131336 90388 31475544
Atrial fibrillation 177.22 11.76 128 131284 113655 31452277
Blood prolactin abnormal 174.32 11.76 81 131331 793 31565139
Poisoning 173.83 11.76 215 131197 10176 31555756
Bipolar disorder 171.06 11.76 134 131278 3590 31562342
Weight increased 166.23 11.76 733 130679 82214 31483718
Euphoric mood 163.79 11.76 147 131265 4773 31561159
Anxiety 160.65 11.76 775 130637 90258 31475674
Hallucination, visual 160.03 11.76 257 131155 15537 31550395
Rhabdomyolysis 159.19 11.76 602 130810 62979 31502953
Tremor 158.21 11.76 682 130730 75738 31490194
Cough 156.99 11.76 197 131215 134617 31431315
Tachycardia 156.92 11.76 679 130733 75528 31490404
Psychiatric decompensation 155.93 11.76 99 131313 1877 31564055
Hyperprolactinaemia 154.58 11.76 89 131323 1402 31564530
Emotional poverty 154.30 11.76 63 131349 436 31565496
Cardiac failure congestive 154.15 11.76 68 131344 79319 31486613
Bradykinesia 147.43 11.76 121 131291 3471 31562461
Neuropathy peripheral 145.00 11.76 66 131346 75583 31490349
Plasma cell myeloma 144.93 11.76 29 131383 56502 31509430
Pyrexia 144.34 11.76 709 130703 303131 31262801
Pain 143.90 11.76 354 131058 186405 31379527
Antipsychotic drug level below therapeutic 141.92 11.76 94 131318 1921 31564011
Rheumatoid arthritis 139.58 11.76 17 131395 47792 31518140
Disinhibition 137.06 11.76 103 131309 2590 31563342
Speech disorder 136.83 11.76 307 131105 23894 31542038
Sepsis 136.82 11.76 264 131148 151665 31414267
Sexual dysfunction 136.19 11.76 145 131267 5823 31560109
Pruritus 133.47 11.76 195 131217 124972 31440960
Acute kidney injury 132.62 11.76 653 130759 279061 31286871
Anosognosia 129.24 11.76 65 131347 768 31565164
Hypomania 128.47 11.76 92 131320 2143 31563789
Apathy 128.03 11.76 146 131266 6336 31559596
Joint swelling 125.82 11.76 33 131379 53398 31512534
Asthenia 124.41 11.76 495 130917 224260 31341672
Type 2 diabetes mellitus 123.82 11.76 221 131191 14563 31551369
Prescribed overdose 122.39 11.76 170 131242 9022 31556910
Irritability 122.36 11.76 284 131128 22605 31543327
Interstitial lung disease 121.73 11.76 51 131361 61352 31504580
Thrombocytopenia 120.87 11.76 257 131155 142490 31423442
Social avoidant behaviour 120.53 11.76 100 131312 2913 31563019
Hyperreflexia 120.32 11.76 99 131313 2850 31563082
Loss of personal independence in daily activities 119.65 11.76 321 131091 27967 31537965
Restless legs syndrome 119.43 11.76 154 131258 7602 31558330
Haemoglobin decreased 116.75 11.76 179 131233 112496 31453436
Insomnia 116.57 11.76 732 130680 94104 31471828
Cognitive disorder 115.85 11.76 293 131119 24630 31541302
Pain in extremity 114.37 11.76 191 131221 116012 31449920
Disturbance in social behaviour 111.64 11.76 77 131335 1686 31564246
Diabetic coma 111.58 11.76 59 131353 779 31565153
Decreased appetite 110.59 11.76 300 131112 152917 31413015
Hyperkalaemia 110.16 11.76 65 131347 64286 31501646
Platelet count decreased 110.10 11.76 180 131232 110255 31455677
Back pain 108.45 11.76 179 131233 109234 31456698
Pleural effusion 108.07 11.76 91 131321 74829 31491103
Infusion related reaction 107.00 11.76 33 131379 48022 31517910
Drug hypersensitivity 102.50 11.76 90 131322 72509 31493423
Metabolic syndrome 100.71 11.76 69 131343 1494 31564438
Infection 99.23 11.76 116 131296 81815 31484117
Mydriasis 99.18 11.76 129 131283 6423 31559509
Bezoar 98.96 11.76 56 131356 852 31565080
Respiratory disorder neonatal 98.70 11.76 67 131345 1428 31564504
Therapeutic product effect variable 98.35 11.76 74 131338 1864 31564068
Headache 98.08 11.76 410 131002 183242 31382690
Respiratory arrest 97.31 11.76 284 131128 25973 31539959
Blood prolactin increased 96.00 11.76 68 131344 1556 31564376
Schizoaffective disorder 95.95 11.76 62 131350 1213 31564719
Urticaria 95.79 11.76 60 131352 57457 31508475
Obesity 95.62 11.76 168 131244 10932 31555000
Stomatitis 93.53 11.76 24 131388 39414 31526518
Psychotic symptom 93.33 11.76 66 131346 1506 31564426
Pancytopenia 93.05 11.76 136 131276 87180 31478752
Sleep disorder 91.97 11.76 279 131133 26069 31539863
Persecutory delusion 91.88 11.76 77 131335 2275 31563657
Withdrawal syndrome 91.58 11.76 170 131242 11547 31554385
Dysarthria 90.95 11.76 316 131096 31701 31534231
Depression suicidal 90.82 11.76 66 131346 1574 31564358
Miosis 90.31 11.76 142 131270 8428 31557504
Dementia 90.01 11.76 174 131238 12186 31553746
Gastrointestinal haemorrhage 87.55 11.76 129 131283 82420 31483512
Increased appetite 86.97 11.76 119 131293 6225 31559707
Disorientation 86.96 11.76 303 131109 30441 31535491
Drug withdrawal syndrome 85.65 11.76 219 131193 18531 31547401
Tearfulness 85.62 11.76 68 131344 1859 31564073
Mental disorder 85.58 11.76 182 131230 13652 31552280
Psychomotor retardation 85.01 11.76 85 131327 3167 31562765
Oedema peripheral 84.62 11.76 208 131204 109631 31456301
Selective eating disorder 83.59 11.76 64 131348 1656 31564276
Salivary hypersecretion 83.34 11.76 130 131282 7662 31558270
Suicidal behaviour 82.43 11.76 59 131353 1373 31564559
Nasopharyngitis 81.57 11.76 85 131327 63160 31502772
Psychomotor skills impaired 80.40 11.76 81 131331 3046 31562886
Depressive symptom 80.10 11.76 68 131344 2046 31563886
Anger 79.99 11.76 156 131256 10997 31554935
Myocardial infarction 79.68 11.76 225 131187 113229 31452703
Hypertonia neonatal 79.30 11.76 38 131374 401 31565531
Mental impairment 79.19 11.76 142 131270 9390 31556542
Pneumonitis 77.97 11.76 16 131396 30636 31535296
Myocarditis 77.63 11.76 160 131252 11740 31554192
Posture abnormal 77.40 11.76 66 131346 1998 31563934
Sedation complication 76.92 11.76 57 131355 1402 31564530
Suspected suicide 76.90 11.76 90 131322 4017 31561915
Epistaxis 76.50 11.76 66 131346 53641 31512291
Drug screen positive 76.47 11.76 87 131325 3765 31562167
Bruxism 75.61 11.76 59 131353 1571 31564361
Herpes zoster 74.85 11.76 20 131392 31973 31533959
Cogwheel rigidity 73.55 11.76 53 131359 1247 31564685
Sinusitis 73.49 11.76 30 131382 36666 31529266
Akinesia 72.84 11.76 63 131349 1945 31563987
Agitation neonatal 72.61 11.76 49 131363 1034 31564898
Metabolic disorder 72.61 11.76 86 131326 3888 31562044
Prostate cancer 71.71 11.76 33 131379 37568 31528364
Coronary artery disease 71.47 11.76 52 131360 46035 31519897
Seizure 71.45 11.76 679 130733 99089 31466843
Stupor 71.36 11.76 72 131340 2712 31563220
Coma scale abnormal 68.73 11.76 81 131331 3642 31562290
Dysphoria 68.58 11.76 63 131349 2109 31563823
Dyspnoea exertional 68.20 11.76 38 131374 38799 31527133
On and off phenomenon 68.18 11.76 62 131350 2048 31563884
Ascites 67.98 11.76 43 131369 40970 31524962
Abdominal pain 67.65 11.76 343 131069 145609 31420323
Loss of consciousness 67.58 11.76 550 130862 76805 31489127
Hyperthermia 67.02 11.76 136 131276 9868 31556064
Acute myocardial infarction 67.02 11.76 67 131345 50756 31515176
Pneumonia aspiration 66.98 11.76 328 131084 38398 31527534
Depressed mood 66.95 11.76 192 131220 17383 31548549
Cytomegalovirus infection 66.92 11.76 11 131401 24696 31541236
Neonatal behavioural syndrome 66.59 11.76 24 131388 112 31565820
Anaphylactic reaction 66.31 11.76 20 131392 29533 31536399
Thrombosis 66.13 11.76 54 131358 45097 31520835
Mucosal inflammation 65.99 11.76 30 131382 34397 31531535
Neonatal respiratory distress syndrome 65.96 11.76 81 131331 3804 31562128
COVID-19 64.88 11.76 79 131333 54742 31511190
Treatment noncompliance 64.88 11.76 244 131168 25440 31540492
Homicidal ideation 64.58 11.76 66 131346 2525 31563407
Antipsychotic drug level above therapeutic 64.35 11.76 47 131365 1130 31564802
Drug dependence 64.25 11.76 223 131189 22356 31543576
Visceral congestion 63.90 11.76 35 131377 498 31565434
Hyperkinesia 63.77 11.76 54 131358 1619 31564313
Renal failure 63.51 11.76 279 131133 123051 31442881
Unresponsive to stimuli 63.44 11.76 243 131169 25557 31540375
Hypertriglyceridaemia 63.29 11.76 115 131297 7683 31558249
Chills 61.43 11.76 135 131277 74015 31491917
Sinus tachycardia 61.20 11.76 174 131238 15675 31550257
Renal impairment 60.78 11.76 171 131241 86178 31479754
Major depression 60.15 11.76 81 131331 4172 31561760
Pneumocystis jirovecii pneumonia 59.93 11.76 4 131408 18247 31547685
Colitis 59.73 11.76 33 131379 33854 31532078
Clonus 58.89 11.76 62 131350 2457 31563475
Psychiatric symptom 57.78 11.76 70 131342 3241 31562691
Weight decreased 57.70 11.76 407 131005 159545 31406387
Delusional disorder, persecutory type 57.46 11.76 26 131386 238 31565694
Vomiting 57.28 11.76 623 130789 223350 31342582
Basal cell carcinoma 56.82 11.76 5 131407 18174 31547758
Multiple drug therapy 56.68 11.76 30 131382 397 31565535
Cardio-respiratory arrest 56.62 11.76 388 131024 51338 31514594
Malignant catatonia 56.20 11.76 25 131387 219 31565713
Wrong product administered 56.10 11.76 85 131327 4883 31561049
Hypothermia 56.10 11.76 123 131289 9421 31556511
Logorrhoea 55.86 11.76 58 131354 2261 31563671
Chronic obstructive pulmonary disease 55.68 11.76 63 131349 45103 31520829
Hypotonia neonatal 55.62 11.76 45 131367 1264 31564668
Neoplasm progression 54.96 11.76 9 131403 20263 31545669
Medication error 54.77 11.76 213 131199 22559 31543373
Malaise 54.53 11.76 442 130970 168069 31397863
Blood pressure increased 54.36 11.76 160 131252 79473 31486459
Loss of libido 54.31 11.76 58 131354 2337 31563595
Prescription drug used without a prescription 54.24 11.76 46 131366 1382 31564550
Excessive eye blinking 54.08 11.76 31 131381 484 31565448
Arthritis 53.84 11.76 23 131389 27362 31538570
Small for dates baby 53.82 11.76 71 131341 3584 31562348
Cardiac failure 53.54 11.76 180 131232 85773 31480159
Myoclonus 53.44 11.76 153 131259 13837 31552095
Influenza 53.38 11.76 63 131349 44262 31521670
Torticollis 53.21 11.76 41 131371 1071 31564861
Faecaloma 53.06 11.76 80 131332 4576 31561356
Asthma 53.01 11.76 59 131353 42552 31523380
Cellulitis 52.90 11.76 73 131339 47945 31517987
Thinking abnormal 52.80 11.76 88 131324 5485 31560447
Arthropathy 52.66 11.76 17 131395 24034 31541898
Colitis ischaemic 52.64 11.76 92 131320 5960 31559972
Blood triglycerides increased 52.63 11.76 148 131264 13249 31552683
Disturbance in attention 52.39 11.76 208 131204 22242 31543690
Sexually inappropriate behaviour 51.90 11.76 29 131383 430 31565502
Peripheral swelling 51.85 11.76 129 131283 67736 31498196
Urinary retention 51.59 11.76 276 131136 33449 31532483
Chest discomfort 51.49 11.76 78 131334 49291 31516641
Personality change 51.28 11.76 80 131332 4715 31561217
Sleep-related eating disorder 51.03 11.76 25 131387 278 31565654
Poor quality sleep 50.98 11.76 104 131308 7574 31558358
Somnambulism 50.92 11.76 61 131351 2791 31563141
Accidental death 50.82 11.76 54 131358 2163 31563769
Slow speech 50.74 11.76 39 131373 1015 31564917
Productive cough 50.51 11.76 39 131373 33501 31532431
Erythema 50.33 11.76 168 131244 80237 31485695
Multiple organ dysfunction syndrome 50.29 11.76 132 131280 68071 31497861
Hypokinesia 49.52 11.76 106 131306 7986 31557946
Brugada syndrome 49.37 11.76 33 131379 685 31565247
Psoriatic arthropathy 49.30 11.76 11 131401 19872 31546060
Acute myeloid leukaemia 49.06 11.76 9 131403 18663 31547269
Hypersensitivity 48.24 11.76 99 131313 55644 31510288
Haemorrhage 48.20 11.76 76 131336 47258 31518674
Stereotypy 47.80 11.76 32 131380 666 31565266
Osteonecrosis of jaw 47.59 11.76 7 131405 17064 31548868
Oedema 47.59 11.76 64 131348 42497 31523435
Myelosuppression 46.92 11.76 4 131408 14916 31551016
Abdominal discomfort 46.85 11.76 89 131323 51478 31514454
Urinary incontinence 46.64 11.76 168 131244 17152 31548780
Stoma site erythema 46.40 11.76 31 131381 643 31565289
Antipsychotic drug level increased 46.10 11.76 64 131348 3394 31562538
Cerebrovascular accident 45.79 11.76 172 131240 79312 31486620
Psoriasis 45.71 11.76 77 131335 46642 31519290
Lung disorder 45.65 11.76 40 131372 32272 31533660
Derealisation 45.39 11.76 29 131383 556 31565376
Epilepsy 45.18 11.76 190 131222 20851 31545081
Abulia 45.07 11.76 28 131384 510 31565422
Oppositional defiant disorder 45.07 11.76 28 131384 510 31565422
Diet refusal 44.99 11.76 23 131389 282 31565650
Blood creatinine increased 44.93 11.76 203 131209 88875 31477057
Granulocytopenia 44.57 11.76 86 131326 6013 31559919
Tension 44.56 11.76 48 131364 1953 31563979
Affect lability 44.51 11.76 63 131349 3402 31562530
Aspiration 44.47 11.76 121 131291 10625 31555307
Inflammation 43.88 11.76 25 131387 25216 31540716
Diabetic ketoacidosis 43.85 11.76 162 131250 16743 31549189
Electrocardiogram abnormal 43.25 11.76 100 131312 7936 31557996
Myelodysplastic syndrome 43.24 11.76 13 131399 19238 31546694
Upper gastrointestinal haemorrhage 43.19 11.76 21 131391 23162 31542770
Septic shock 42.95 11.76 136 131276 66022 31499910
Bone marrow failure 42.90 11.76 32 131380 27976 31537956
Freezing phenomenon 42.81 11.76 39 131373 1291 31564641
Atrial septal defect 42.69 11.76 91 131321 6836 31559096
Anticonvulsant drug level above therapeutic 42.56 11.76 29 131383 622 31565310
Decreased eye contact 42.37 11.76 26 131386 463 31565469
Vein of Galen aneurysmal malformation 41.81 11.76 11 131401 11 31565921
Palmar-plantar erythrodysaesthesia syndrome 41.69 11.76 7 131405 15476 31550456
Oropharyngeal spasm 41.44 11.76 18 131394 148 31565784
Suspiciousness 41.31 11.76 22 131390 295 31565637
Dehydration 41.03 11.76 307 131105 118804 31447128
Hypoaesthesia 40.86 11.76 109 131303 55913 31510019
Trismus 40.60 11.76 50 131362 2355 31563577
Otospondylomegaepiphyseal dysplasia 40.42 11.76 16 131396 101 31565831
Sudden cardiac death 40.36 11.76 60 131352 3389 31562543
Gambling disorder 40.28 11.76 41 131371 1561 31564371
Grimacing 40.20 11.76 21 131391 270 31565662
Judgement impaired 40.16 11.76 27 131385 566 31565366
Death 40.08 11.76 1164 130248 359405 31206527
Hepatic failure 39.89 11.76 46 131366 32656 31533276
Product substitution issue 39.83 11.76 107 131305 9325 31556607
Pulmonary fibrosis 39.76 11.76 10 131402 16650 31549282
Chest pain 39.55 11.76 303 131109 116654 31449278
Muscle twitching 39.53 11.76 98 131314 8132 31557800
Bronchopulmonary aspergillosis 39.41 11.76 5 131407 13629 31552303
Temperature regulation disorder 38.99 11.76 27 131385 595 31565337
Psychosexual disorder 38.81 11.76 15 131397 88 31565844
Stoma site discharge 38.77 11.76 32 131380 925 31565007
Poverty of speech 38.65 11.76 19 131393 213 31565719
Embolism venous 38.60 11.76 38 131374 1389 31564543
International normalised ratio increased 38.55 11.76 81 131331 45142 31520790
Haemoptysis 38.49 11.76 46 131366 32143 31533789
Flushing 38.26 11.76 41 131371 30087 31535845
Dyslipidaemia 38.15 11.76 83 131329 6323 31559609
Reduced facial expression 37.96 11.76 30 131382 814 31565118
Diverticulitis 37.72 11.76 15 131397 18630 31547302
Chronic kidney disease 37.70 11.76 62 131350 37913 31528019
Feeling jittery 37.62 11.76 61 131351 3716 31562216
Full blood count decreased 37.46 11.76 11 131401 16529 31549403
Pleurothotonus 37.32 11.76 33 131379 1050 31564882
Libido increased 37.12 11.76 28 131384 708 31565224
Synovitis 36.76 11.76 4 131408 12279 31553653
Bipolar I disorder 36.76 11.76 29 131383 785 31565147
Prostatic specific antigen increased 36.72 11.76 6 131406 13532 31552400
Mood altered 36.58 11.76 96 131316 8250 31557682
Large for dates baby 36.56 11.76 30 131382 860 31565072
Accidental overdose 36.55 11.76 162 131250 18188 31547744
Drooling 36.44 11.76 54 131358 3041 31562891
Blood bilirubin increased 36.16 11.76 56 131356 35080 31530852
Nephrolithiasis 36.08 11.76 36 131376 27303 31538629
Cytokine release syndrome 36.02 11.76 12 131400 16630 31549302
Personality disorder 35.94 11.76 33 131379 1104 31564828
Skin ulcer 35.89 11.76 19 131393 19966 31545966
Rash pruritic 35.83 11.76 28 131384 23910 31542022
Tic 35.80 11.76 42 131370 1879 31564053
Electrocardiogram QT interval abnormal 35.42 11.76 14 131398 88 31565844
Musculoskeletal pain 35.26 11.76 43 131369 29785 31536147
Hyperammonaemia 35.22 11.76 76 131336 5757 31560175
Substance abuse 35.19 11.76 86 131326 7072 31558860
Neonatal seizure 35.11 11.76 23 131389 461 31565471
Device related infection 34.85 11.76 12 131400 16287 31549645
Dystonic tremor 34.78 11.76 17 131395 188 31565744
Haematuria 34.62 11.76 89 131323 46225 31519707
Fall 34.60 11.76 1013 130399 185076 31380856
Paradoxical drug reaction 34.58 11.76 53 131359 3076 31562856
Gout 34.57 11.76 16 131396 18158 31547774
Vasoplegia syndrome 34.53 11.76 39 131373 1674 31564258
Haemophagocytic lymphohistiocytosis 34.45 11.76 4 131408 11674 31554258
Respiratory depression 34.30 11.76 135 131277 14375 31551557
Device dislocation 34.23 11.76 70 131342 5106 31560826
Impulsive behaviour 34.22 11.76 42 131370 1971 31563961
Upper respiratory tract infection 34.17 11.76 43 131369 29379 31536553
Bronchitis 34.14 11.76 68 131344 38649 31527283
Dementia with Lewy bodies 34.05 11.76 26 131386 670 31565262
Brachial plexopathy 34.01 11.76 12 131400 52 31565880
Hangover 33.91 11.76 30 131382 955 31564977
Incoherent 33.69 11.76 62 131350 4182 31561750
Wheezing 33.67 11.76 61 131351 35925 31530007
Overweight 33.54 11.76 37 131375 1547 31564385
Swelling 33.47 11.76 65 131347 37293 31528639
Acute psychosis 33.30 11.76 39 131373 1742 31564190
Trichoglossia 33.12 11.76 18 131394 252 31565680
Distributive shock 32.86 11.76 31 131381 1074 31564858
Hypertonia 32.81 11.76 59 131353 3909 31562023
Lymphadenopathy 32.67 11.76 36 131376 26085 31539847
Hypocalcaemia 32.53 11.76 26 131386 21952 31543980
Coordination abnormal 32.39 11.76 84 131328 7167 31558765
Neonatal toxicity 32.20 11.76 10 131402 26 31565906
Tachyphrenia 32.16 11.76 32 131380 1185 31564747
Oral discharge 32.04 11.76 14 131398 117 31565815
Hyperosmolar state 31.92 11.76 20 131392 370 31565562
Muscular weakness 31.89 11.76 151 131261 65297 31500635
Pruritus genital 31.88 11.76 23 131389 542 31565390
Staring 31.87 11.76 34 131378 1368 31564564
Tumour lysis syndrome 31.75 11.76 12 131400 15373 31550559
Anxiolytic therapy 31.67 11.76 11 131401 45 31565887
Gastrointestinal disorder 31.43 11.76 49 131363 30611 31535321
Anticholinergic syndrome 31.36 11.76 30 131382 1058 31564874
Flight of ideas 31.32 11.76 19 131393 331 31565601
Squamous cell carcinoma of skin 31.26 11.76 3 131409 10171 31555761
Dependence 31.22 11.76 30 131382 1064 31564868
Bladder cancer 31.21 11.76 11 131401 14714 31551218
Exposure via ingestion 30.85 11.76 40 131372 1985 31563947
Injection site pain 30.39 11.76 61 131351 34573 31531359
Nightmare 30.39 11.76 115 131297 12022 31553910
Panic attack 30.21 11.76 92 131320 8611 31557321
Hypomagnesaemia 30.20 11.76 21 131391 19037 31546895
Behaviour disorder 30.19 11.76 60 131352 4287 31561645
Drug therapy enhancement 30.07 11.76 11 131401 54 31565878
Colitis ulcerative 29.92 11.76 20 131392 18509 31547423
Neoplasm malignant 29.81 11.76 21 131391 18910 31547022
Rebound effect 29.81 11.76 44 131368 2469 31563463
Excessive masturbation 29.64 11.76 12 131400 81 31565851
Transplant rejection 29.46 11.76 3 131409 9705 31556227
Alcohol abuse 29.33 11.76 61 131351 4503 31561429
Hypersomnia 29.21 11.76 107 131305 11012 31554920
Screaming 29.18 11.76 32 131380 1329 31564603
Impulse-control disorder 29.11 11.76 31 131381 1245 31564687
Nonspecific reaction 29.03 11.76 30 131382 1163 31564769
Abdominal distension 28.97 11.76 110 131302 50574 31515358
Withdrawal arrhythmia 28.97 11.76 10 131402 40 31565892
Pseudomonas infection 28.89 11.76 6 131406 11395 31554537
Stoma site hypergranulation 28.79 11.76 14 131398 153 31565779
Dacryostenosis congenital 28.78 11.76 10 131402 41 31565891
Resting tremor 28.52 11.76 23 131389 643 31565289
Hypoglycaemia neonatal 28.40 11.76 36 131376 1746 31564186
Neonatal tachypnoea 28.32 11.76 14 131398 159 31565773
Blister 28.28 11.76 27 131385 20909 31545023
Heart rate decreased 28.19 11.76 46 131366 28220 31537712
Illusion 27.83 11.76 24 131388 738 31565194
Haematochezia 27.81 11.76 81 131331 40383 31525549
Leukopenia 27.80 11.76 364 131048 57464 31508468
Jealous delusion 27.79 11.76 16 131396 252 31565680
Skin lesion 27.79 11.76 24 131388 19503 31546429
Cholestasis 27.73 11.76 38 131374 25037 31540895
Atrial flutter 27.72 11.76 13 131399 14642 31551290
Affective disorder 27.69 11.76 53 131359 3683 31562249
Pyromania 27.69 11.76 10 131402 47 31565885
Delusional disorder, unspecified type 27.63 11.76 23 131389 673 31565259
Myalgia 27.61 11.76 197 131215 77061 31488871
Cholecystitis 27.43 11.76 4 131408 9813 31556119
Alcoholism 27.42 11.76 50 131362 3349 31562583
Feelings of worthlessness 27.24 11.76 16 131396 262 31565670
Oropharyngeal pain 27.16 11.76 56 131356 31427 31534505
Patent ductus arteriosus 27.07 11.76 48 131364 3145 31562787
Amnesia 27.07 11.76 178 131234 23224 31542708
Blood cholesterol increased 27.02 11.76 140 131272 16753 31549179
Lung neoplasm malignant 26.91 11.76 17 131395 16213 31549719
Self-injurious ideation 26.80 11.76 33 131379 1554 31564378
Stoma site infection 26.46 11.76 23 131389 715 31565217
Hyperammonaemic encephalopathy 26.44 11.76 39 131373 2187 31563745
Dyspepsia 26.34 11.76 60 131352 32493 31533439
Congestive cardiomyopathy 26.32 11.76 76 131336 6906 31559026
Rectal haemorrhage 26.19 11.76 71 131341 36233 31529699
Coagulopathy 26.05 11.76 23 131389 18492 31547440
Fungal infection 25.88 11.76 14 131398 14537 31551395
Hypoacusis 25.86 11.76 15 131397 14984 31550948
Galactorrhoea 25.75 11.76 18 131394 403 31565529
Gaze palsy 25.69 11.76 31 131381 1429 31564503
Angioedema 25.59 11.76 64 131348 33554 31532378
Blepharospasm 25.56 11.76 27 131385 1074 31564858
Blood urea increased 25.54 11.76 51 131361 28961 31536971
Diffuse large B-cell lymphoma 25.39 11.76 3 131409 8638 31557294
Encephalopathy neonatal 25.32 11.76 9 131403 40 31565892
Blood pressure systolic increased 25.28 11.76 26 131386 19444 31546488
Illness anxiety disorder 25.24 11.76 13 131399 162 31565770
Troponin increased 25.23 11.76 95 131317 9907 31556025
Tachycardia foetal 25.18 11.76 17 131395 359 31565573
Choreoathetosis 25.18 11.76 26 131386 1007 31564925
Meconium aspiration syndrome 24.80 11.76 9 131403 43 31565889
Rash maculo-papular 24.59 11.76 43 131369 25676 31540256
Impaired self-care 24.28 11.76 25 131387 965 31564967
Refusal of treatment by patient 24.26 11.76 58 131354 4703 31561229
Peritonitis 24.14 11.76 17 131395 15310 31550622
Paraesthesia 24.13 11.76 135 131277 55936 31509996
Hypervolaemia 24.12 11.76 24 131388 18227 31547705
Intentional product use issue 23.95 11.76 114 131298 49233 31516699
Localised infection 23.95 11.76 17 131395 15248 31550684
Gastrointestinal necrosis 23.90 11.76 45 131367 3089 31562843
Incontinence 23.65 11.76 62 131350 5324 31560608
Urine alcohol test positive 23.58 11.76 8 131404 30 31565902
Appendicitis 23.56 11.76 9 131403 11456 31554476
Bacteraemia 23.52 11.76 23 131389 17611 31548321
Cerebral infarction 23.44 11.76 45 131367 25932 31540000
Salivary gland calculus 23.40 11.76 9 131403 52 31565880
Rhinorrhoea 23.37 11.76 37 131375 22975 31542957
Acute respiratory failure 23.28 11.76 51 131361 28004 31537928
Fluid retention 23.23 11.76 42 131370 24760 31541172
Acute coronary syndrome 23.20 11.76 12 131400 12777 31553155
Penile haemorrhage 23.19 11.76 20 131392 615 31565317
Hallucinations, mixed 23.14 11.76 39 131373 2453 31563479
Gynaecomastia 23.14 11.76 87 131325 9067 31556865
Crying 23.14 11.76 63 131349 5534 31560398
Cholelithiasis 23.11 11.76 28 131384 19451 31546481
Renal disorder 23.10 11.76 39 131373 23606 31542326
Oesophageal carcinoma 23.09 11.76 3 131409 8030 31557902
Osteoarthritis 23.06 11.76 27 131385 19040 31546892
Pulmonary mass 23.03 11.76 9 131403 11297 31554635
Penis injury 22.93 11.76 14 131398 247 31565685
Rebound psychosis 22.86 11.76 12 131400 156 31565776
Bone pain 22.76 11.76 28 131384 19323 31546609
Enuresis 22.75 11.76 36 131376 2148 31563784
Feeling guilty 22.67 11.76 15 131397 306 31565626
Necrotising colitis 22.63 11.76 25 131387 1047 31564885
Type 1 diabetes mellitus 22.62 11.76 50 131362 3850 31562082
Maternal drugs affecting foetus 22.59 11.76 50 131362 3853 31562079
Mood swings 22.59 11.76 75 131337 7349 31558583
Pulmonary hypertension 22.54 11.76 30 131382 20011 31545921
Dizziness 22.51 11.76 641 130771 198506 31367426
pH body fluid decreased 22.45 11.76 5 131407 0 31565932
Laboratory test abnormal 22.37 11.76 27 131385 18787 31547145
Tremor neonatal 22.18 11.76 16 131396 377 31565555
Autonomic nervous system imbalance 22.11 11.76 38 131374 2429 31563503
Product communication issue 22.08 11.76 15 131397 320 31565612
Osteomyelitis 22.08 11.76 17 131395 14626 31551306
Blunted affect 22.04 11.76 15 131397 321 31565611
Opisthotonus 22.03 11.76 17 131395 445 31565487
Staphylococcal infection 22.02 11.76 60 131352 30572 31535360
Intentional medical device removal by patient 22.02 11.76 14 131398 266 31565666
Melaena 21.98 11.76 66 131346 32588 31533344
Dysphonia 21.98 11.76 32 131380 20559 31545373
Pancreatitis 21.97 11.76 236 131176 35535 31530397
Drug diversion 21.97 11.76 22 131390 821 31565111
Verbal abuse 21.95 11.76 12 131400 170 31565762
Subgaleal haematoma 21.92 11.76 8 131404 39 31565893
Renal cancer 21.75 11.76 3 131409 7676 31558256
Stoma site inflammation 21.74 11.76 17 131395 454 31565478
Incorrect route of product administration 21.71 11.76 101 131311 11572 31554360
Interleukin level increased 21.69 11.76 10 131402 96 31565836
Encephalitis toxic 21.66 11.76 14 131398 274 31565658
Hypospadias 21.63 11.76 43 131369 3073 31562859
Emotional disorder 21.61 11.76 59 131353 5190 31560742
Hypercalcaemia 21.43 11.76 16 131396 13984 31551948
Brain injury 21.40 11.76 63 131349 5787 31560145
Pulmonary arterial hypertension 21.40 11.76 7 131405 9814 31556118
Schizophreniform disorder 21.37 11.76 9 131403 68 31565864
Immune reconstitution inflammatory syndrome 21.36 11.76 4 131408 8174 31557758
Drug level increased 21.24 11.76 150 131262 20036 31545896
Slow response to stimuli 21.23 11.76 21 131391 772 31565160
Postmortem blood drug level increased 21.21 11.76 13 131399 231 31565701
Water intoxication 21.20 11.76 16 131396 405 31565527
Renal tubular necrosis 21.17 11.76 18 131394 14741 31551191
Hepatotoxicity 21.13 11.76 29 131383 19097 31546835
End stage renal disease 21.11 11.76 4 131408 8105 31557827
Osteonecrosis 21.08 11.76 16 131396 13868 31552064
Proteinuria 21.07 11.76 23 131389 16740 31549192
Pyramidal tract syndrome 21.01 11.76 12 131400 186 31565746
Hepatitis 21 11.76 37 131375 22029 31543903
Newborn persistent pulmonary hypertension 20.99 11.76 10 131402 104 31565828
Renal injury 20.89 11.76 9 131403 10656 31555276
Pulmonary haemorrhage 20.69 11.76 7 131405 9608 31556324
Stoma site pain 20.67 11.76 18 131394 561 31565371
Cholangitis 20.66 11.76 4 131408 7982 31557950
Abdominal pain upper 20.59 11.76 168 131244 63834 31502098
Sudden death 20.54 11.76 116 131296 14341 31551591
Epidermolysis bullosa 20.43 11.76 10 131402 111 31565821
Tooth disorder 20.40 11.76 8 131404 10021 31555911
Congenital cerebrovascular anomaly 20.40 11.76 6 131406 12 31565920
Penoscrotal fusion 20.40 11.76 6 131406 12 31565920
Self-medication 20.37 11.76 35 131377 2236 31563696
Muscle spasms 20.34 11.76 183 131229 68135 31497797
Ketoacidosis 20.31 11.76 48 131364 3864 31562068
Postural orthostatic tachycardia syndrome 20.28 11.76 8 131404 50 31565882
Hyperhidrosis 20.19 11.76 392 131020 67001 31498931
Polydipsia 20.10 11.76 45 131367 3495 31562437
Inappropriate affect 20.06 11.76 18 131394 584 31565348
COVID-19 pneumonia 19.98 11.76 14 131398 12641 31553291
Metastases to bone 19.94 11.76 10 131402 10838 31555094
Hepatic cancer 19.89 11.76 4 131408 7771 31558161
Mutism 19.81 11.76 20 131392 754 31565178
Gastrointestinal hypomotility 19.80 11.76 22 131390 927 31565005
Haemorrhage intracranial 19.75 11.76 20 131392 15068 31550864
Device kink 19.73 11.76 15 131397 384 31565548
Nervousness 19.72 11.76 99 131313 11701 31554231
Erectile dysfunction 19.69 11.76 142 131270 19093 31546839
Hyperdynamic left ventricle 19.63 11.76 11 131401 164 31565768
Spasmodic dysphonia 19.63 11.76 11 131401 164 31565768
Cerebral amyloid angiopathy 19.60 11.76 10 131402 122 31565810
Enteritis 19.58 11.76 3 131409 7096 31558836
Angina unstable 19.58 11.76 11 131401 11184 31554748
Brain hypoxia 19.55 11.76 14 131398 326 31565606
Neck pain 19.55 11.76 41 131371 22869 31543063
Parkinsonian rest tremor 19.53 11.76 10 131402 123 31565809
Squamous cell carcinoma 19.50 11.76 10 131402 10701 31555231
Tubulointerstitial nephritis 19.49 11.76 29 131383 18467 31547465
Hyperglycaemia 19.41 11.76 234 131178 36242 31529690
Drug dispensed to wrong patient 19.37 11.76 16 131396 463 31565469
Borderline personality disorder 19.30 11.76 14 131398 333 31565599
Hepatic encephalopathy 19.21 11.76 17 131395 13654 31552278
Junctional ectopic tachycardia 19.21 11.76 6 131406 16 31565916
Choking 19.15 11.76 52 131360 4560 31561372
Therapy interrupted 19.13 11.76 10 131402 10586 31555346
Injection site erythema 19.13 11.76 19 131393 14443 31551489
Attention deficit hyperactivity disorder 19.00 11.76 35 131377 2363 31563569
Antipsychotic drug level decreased 18.98 11.76 21 131391 881 31565051
Painful erection 18.97 11.76 12 131400 226 31565706
Respiratory failure 18.95 11.76 301 131111 101148 31464784
Full blood count abnormal 18.87 11.76 24 131388 16323 31549609
Liver function test increased 18.86 11.76 15 131397 12699 31553233
Haemangioma congenital 18.80 11.76 16 131396 483 31565449
Lymphoma 18.79 11.76 11 131401 10932 31555000
Parkinsonian gait 18.77 11.76 16 131396 484 31565448
Obstructive airways disorder 18.72 11.76 15 131397 12649 31553283
Compartment syndrome 18.71 11.76 37 131375 2634 31563298
Ejection fraction decreased 18.70 11.76 27 131385 17407 31548525
IVth nerve disorder 18.70 11.76 6 131406 18 31565914
Finnegan score increased 18.70 11.76 6 131406 18 31565914
Myocardial ischaemia 18.69 11.76 25 131387 16642 31549290
Talipes 18.64 11.76 30 131382 1816 31564116
Myoclonic epilepsy 18.58 11.76 23 131389 1089 31564843
Eye movement disorder 18.57 11.76 46 131366 3815 31562117
Skin exfoliation 18.52 11.76 45 131367 23829 31542103
Panic disorder 18.40 11.76 24 131388 1198 31564734
Dysgeusia 18.38 11.76 44 131368 23422 31542510
Compulsions 18.37 11.76 11 131401 187 31565745
Metastases to lung 18.35 11.76 6 131406 8416 31557516
Posturing 18.33 11.76 16 131396 500 31565432
Memory impairment 18.31 11.76 240 131172 37890 31528042
Troponin I increased 18.31 11.76 32 131380 2073 31563859
Flashback 18.27 11.76 10 131402 142 31565790
Skin cancer 18.26 11.76 8 131404 9377 31556555
Dry skin 18.25 11.76 50 131362 25431 31540501
Treatment failure 18.22 11.76 97 131315 40695 31525237
Influenza like illness 18.16 11.76 50 131362 25387 31540545
Waxy flexibility 18.14 11.76 9 131403 103 31565829
Ventricular tachycardia 18.13 11.76 45 131367 23656 31542276
Language disorder 18.11 11.76 32 131380 2091 31563841
Perseveration 17.99 11.76 9 131403 105 31565827
Acoustic stimulation tests abnormal 17.99 11.76 8 131404 70 31565862
Contraindication to medical treatment 17.83 11.76 17 131395 597 31565335
Condition aggravated 17.82 11.76 841 130571 163168 31402764
Angina pectoris 17.81 11.76 63 131349 29578 31536354
Phaeochromocytoma malignant 17.80 11.76 8 131404 72 31565860
Blood urine present 17.74 11.76 10 131402 10147 31555785
Alcohol use 17.69 11.76 40 131372 3127 31562805
Hypoalbuminaemia 17.67 11.76 12 131400 11016 31554916
Knee arthroplasty 17.58 11.76 3 131409 6555 31559377
Mental status changes 17.53 11.76 227 131185 35741 31530191
Ataxia 17.49 11.76 102 131310 12761 31553171
Toxic epidermal necrolysis 17.46 11.76 34 131378 19490 31546442
Hot flush 17.45 11.76 25 131387 16171 31549761
Camptocormia 17.40 11.76 10 131402 157 31565775
Cleft lip and palate 17.34 11.76 15 131397 463 31565469
Colon cancer 17.31 11.76 7 131405 8606 31557326
Kidney duplex 17.28 11.76 14 131398 394 31565538
Orthostatic hypertension 17.27 11.76 12 131400 266 31565666
Bundle branch block right 17.13 11.76 66 131346 6958 31558974
Status epilepticus 17.11 11.76 97 131315 12009 31553923
Substance use 17.11 11.76 16 131396 548 31565384
Cryptorchism 17.01 11.76 30 131382 1957 31563975
Laryngospasm 17.01 11.76 24 131388 1292 31564640
Lower respiratory tract infection 16.98 11.76 60 131352 28177 31537755
Blood lactic acid increased 16.96 11.76 60 131352 6070 31559862
Blood pressure diastolic decreased 16.96 11.76 6 131406 8007 31557925
Intercepted medication error 16.94 11.76 15 131397 478 31565454
Clostridium difficile colitis 16.89 11.76 20 131392 14036 31551896
Patient isolation 16.82 11.76 6 131406 27 31565905
Retrograde ejaculation 16.66 11.76 13 131399 346 31565586
Motor dysfunction 16.65 11.76 61 131351 6278 31559654
Erection increased 16.61 11.76 15 131397 491 31565441
Lymphopenia 16.57 11.76 21 131391 14308 31551624
Vascular stenosis 16.55 11.76 10 131402 173 31565759
Conduction disorder 16.52 11.76 29 131383 1885 31564047
Generalised tonic-clonic seizure 16.46 11.76 140 131272 19791 31546141
Alcohol interaction 16.45 11.76 36 131376 2753 31563179
Prescribed underdose 16.42 11.76 73 131339 8205 31557727
Neuralgia 16.38 11.76 15 131397 11851 31554081
Convulsive threshold lowered 16.38 11.76 15 131397 500 31565432
Pain in jaw 16.33 11.76 16 131396 12239 31553693
Cardiac failure chronic 16.28 11.76 5 131407 7298 31558634
Eosinophilic pleural effusion 16.26 11.76 11 131401 233 31565699
Injection site pruritus 16.24 11.76 3 131409 6191 31559741
Apraxia 16.23 11.76 23 131389 1243 31564689
Hepatocellular carcinoma 16.21 11.76 8 131404 8748 31557184
Sluggishness 16.18 11.76 38 131374 3046 31562886
Bacterial parotitis 16.15 11.76 6 131406 31 31565901
Delirium febrile 16.15 11.76 6 131406 31 31565901
Infant irritability 16.15 11.76 6 131406 31 31565901
Anaphylactic shock 16.08 11.76 21 131391 14124 31551808
Swelling face 16.06 11.76 41 131371 21349 31544583
Hernia 15.97 11.76 8 131404 8676 31557256
Psychotic disorder due to a general medical condition 15.97 11.76 7 131405 59 31565873
Inappropriate antidiuretic hormone secretion 15.94 11.76 91 131321 11296 31554636
Laryngeal dyspnoea 15.87 11.76 8 131404 95 31565837
Polymerase chain reaction 15.87 11.76 8 131404 95 31565837
Drug withdrawal headache 15.83 11.76 5 131407 14 31565918
Negativism 15.80 11.76 13 131399 374 31565558
Postoperative respiratory failure 15.80 11.76 8 131404 96 31565836
Hypoxia 15.76 11.76 133 131279 50180 31515752
Leukopenia neonatal 15.73 11.76 4 131408 3 31565929
Somatic delusion 15.73 11.76 8 131404 97 31565835
Carbon monoxide poisoning 15.73 11.76 8 131404 97 31565835
Pancreatic carcinoma 15.70 11.76 8 131404 8592 31557340
Transposition of the great vessels 15.69 11.76 14 131398 451 31565481
Acute generalised exanthematous pustulosis 15.68 11.76 3 131409 6037 31559895
Multiple cardiac defects 15.67 11.76 7 131405 62 31565870
Hyperphagia 15.52 11.76 23 131389 1295 31564637
Embedded device 15.52 11.76 11 131401 252 31565680
Congenital cystic kidney disease 15.48 11.76 13 131399 385 31565547
Product storage error 15.46 11.76 5 131407 7061 31558871
Antisocial behaviour 15.43 11.76 12 131400 318 31565614
Hypophosphataemia 15.43 11.76 8 131404 8506 31557426
Drug resistance 15.36 11.76 48 131364 23405 31542527
Sexual abuse 15.34 11.76 9 131403 147 31565785
Obsessive thoughts 15.34 11.76 16 131396 627 31565305
Visual acuity reduced 15.27 11.76 25 131387 15318 31550614
Iron deficiency anaemia 15.25 11.76 10 131402 9349 31556583
Anomaly of external ear congenital 15.24 11.76 8 131404 104 31565828
False positive investigation result 15.20 11.76 12 131400 325 31565607
Large intestine polyp 15.20 11.76 5 131407 6987 31558945
Optic discs blurred 15.20 11.76 7 131405 67 31565865
Ageusia 15.16 11.76 10 131402 9321 31556611
Faeces discoloured 15.13 11.76 21 131391 13765 31552167
Homicide 15.13 11.76 19 131393 913 31565019
Infantile apnoea 15.10 11.76 19 131393 915 31565017
Discomfort 15.05 11.76 28 131384 16328 31549604
Blood creatine phosphokinase decreased 15.03 11.76 14 131398 477 31565455
Stoma site induration 15.01 11.76 6 131406 39 31565893
Muscle hypertrophy 15.01 11.76 6 131406 39 31565893
Psychotic behaviour 14.95 11.76 16 131396 646 31565286
Pharyngeal dystonia 14.93 11.76 7 131405 70 31565862
Communication disorder 14.88 11.76 32 131380 2418 31563514
Injection site swelling 14.84 11.76 12 131400 10075 31555857
Abscess 14.79 11.76 13 131399 10474 31555458
Hyperglycaemic hyperosmolar nonketotic syndrome 14.78 11.76 21 131391 1138 31564794
Clostridium difficile infection 14.68 11.76 31 131381 17248 31548684
Yawning 14.63 11.76 14 131398 494 31565438
Distractibility 14.62 11.76 12 131400 344 31565588
Unevaluable event 14.62 11.76 71 131341 30504 31535428
Brachial plexus injury 14.60 11.76 7 131405 74 31565858
Delusional perception 14.58 11.76 9 131403 162 31565770
Tongue spasm 14.52 11.76 6 131406 43 31565889
Anamnestic reaction 14.52 11.76 6 131406 43 31565889
Fistula 14.52 11.76 3 131409 5718 31560214
Feminisation acquired 14.52 11.76 6 131406 43 31565889
Post procedural haemorrhage 14.49 11.76 7 131405 7751 31558181
Antisocial personality disorder 14.49 11.76 5 131407 20 31565912
Binge eating 14.47 11.76 8 131404 116 31565816
Flatulence 14.47 11.76 36 131376 18912 31547020
Enterocolitis 14.47 11.76 6 131406 7268 31558664
Lymphocyte count decreased 14.43 11.76 41 131371 20608 31545324
Oxygen saturation decreased 14.43 11.76 132 131280 48983 31516949
Injection site haemorrhage 14.41 11.76 10 131402 9075 31556857
Malignant melanoma 14.33 11.76 7 131405 7700 31558232
Shoulder deformity 14.32 11.76 4 131408 6 31565926
Respiratory distress 14.32 11.76 81 131331 33472 31532460
Sexual activity increased 14.29 11.76 5 131407 21 31565911
Haemolysis 14.28 11.76 6 131406 7210 31558722
Hypertension 14.28 11.76 413 130999 127687 31438245
Haematocrit decreased 14.26 11.76 70 131342 29991 31535941
Lactic acidosis 14.23 11.76 76 131336 31861 31534071
Breast inflammation 14.11 11.76 5 131407 22 31565910
Diabetes insipidus 14.10 11.76 32 131380 2508 31563424
Metastases to central nervous system 14.10 11.76 7 131405 7629 31558303
Movement disorder 14.10 11.76 86 131326 10933 31554999
Flat affect 14.05 11.76 17 131395 786 31565146
Hepatitis cholestatic 14.05 11.76 6 131406 7140 31558792
Seasonal allergy 14.04 11.76 3 131409 5585 31560347
Wrong patient 13.98 11.76 9 131403 175 31565757
Lip swelling 13.93 11.76 21 131391 13302 31552630
Shock haemorrhagic 13.89 11.76 13 131399 10164 31555768
Frequent bowel movements 13.84 11.76 13 131399 10146 31555786
Hydrops foetalis 13.81 11.76 13 131399 449 31565483
Cerebral disorder 13.79 11.76 31 131381 2414 31563518
Gastroenteritis 13.77 11.76 21 131391 13241 31552691
Volvulus 13.76 11.76 21 131391 1214 31564718
Somatic symptom disorder 13.75 11.76 15 131397 619 31565313
Blood alkaline phosphatase increased 13.73 11.76 69 131343 29384 31536548
Sciatic nerve neuropathy 13.64 11.76 6 131406 51 31565881
Intermittent explosive disorder 13.60 11.76 4 131408 8 31565924
Delusion of reference 13.59 11.76 5 131407 25 31565907
Nephrotic syndrome 13.58 11.76 6 131406 6997 31558935
Red blood cell sedimentation rate increased 13.48 11.76 9 131403 8337 31557595
Tonic posturing 13.47 11.76 3 131409 0 31565932
Stoma site extravasation 13.47 11.76 7 131405 89 31565843
Medical device site injury 13.47 11.76 3 131409 0 31565932
Electroencephalogram abnormal 13.44 11.76 30 131382 2325 31563607
Alanine aminotransferase increased 13.44 11.76 223 131189 74433 31491499
Alcohol poisoning 13.41 11.76 36 131376 3135 31562797
Epstein-Barr virus infection 13.41 11.76 6 131406 6947 31558985
Metabolic encephalopathy 13.39 11.76 41 131371 3848 31562084
Urinary tract infection 13.38 11.76 231 131181 76638 31489294
Compulsive shopping 13.38 11.76 12 131400 389 31565543
Metastases to liver 13.37 11.76 20 131392 12707 31553225
Small intestinal obstruction 13.36 11.76 22 131390 13450 31552482
Congenital pulmonary valve atresia 13.35 11.76 6 131406 54 31565878
Xanthoma 13.33 11.76 7 131405 91 31565841
Heart rate abnormal 13.31 11.76 25 131387 1713 31564219
Neuroleptic-induced deficit syndrome 13.28 11.76 5 131407 27 31565905
Pulmonary toxicity 13.28 11.76 3 131409 5374 31560558
Maternal exposure during pregnancy 13.25 11.76 46 131366 4610 31561322
Eye pain 13.25 11.76 19 131393 12285 31553647
Loss of employment 13.21 11.76 13 131399 475 31565457
Postmortem blood drug level 13.21 11.76 8 131404 139 31565793
Generalised oedema 13.15 11.76 17 131395 11484 31554448
Sciatica 13.15 11.76 3 131409 5338 31560594
Boredom 13.13 11.76 5 131407 28 31565904
Hyponatraemic coma 13.13 11.76 5 131407 28 31565904
Oral candidiasis 13.06 11.76 16 131396 11061 31554871
Peritonitis bacterial 13.05 11.76 4 131408 5848 31560084
Pneumothorax 13.02 11.76 32 131380 16878 31549054
Subarachnoid haemorrhage 13.01 11.76 14 131398 10257 31555675
Arachnoid cyst 13.01 11.76 9 131403 198 31565734
Divorced 12.99 11.76 4 131408 10 31565922
Obsessive-compulsive personality disorder 12.91 11.76 8 131404 145 31565787
Facial spasm 12.89 11.76 9 131403 201 31565731
Cytopenia 12.88 11.76 16 131396 10994 31554938
Dopamine dysregulation syndrome 12.84 11.76 11 131401 335 31565597
Hepatitis B 12.81 11.76 4 131408 5777 31560155
Mixed dementia 12.79 11.76 10 131402 267 31565665
Oral pain 12.72 11.76 13 131399 9752 31556180
Intestinal haemorrhage 12.71 11.76 36 131376 3235 31562697
Asocial behaviour 12.63 11.76 6 131406 62 31565870
Caesarean section 12.59 11.76 26 131386 1910 31564022
Blood pressure fluctuation 12.57 11.76 50 131362 22686 31543246
Ileus paralytic 12.53 11.76 50 131362 5358 31560574
Pulmonary oedema 12.47 11.76 121 131291 44381 31521551
Device malfunction 12.46 11.76 12 131400 9254 31556678
Mouth ulceration 12.44 11.76 16 131396 10832 31555100
Myoglobin blood increased 12.43 11.76 30 131382 2447 31563485
Dysphagia 12.38 11.76 320 131092 57356 31508576
Respiratory acidosis 12.36 11.76 45 131367 4617 31561315
Cyanosis neonatal 12.36 11.76 10 131402 281 31565651
Intestinal perforation 12.32 11.76 10 131402 8379 31557553
Hostility 12.23 11.76 16 131396 801 31565131
Congenital hydronephrosis 12.22 11.76 15 131397 704 31565228
Corneal reflex decreased 12.14 11.76 8 131404 162 31565770
Endocarditis 12.14 11.76 5 131407 6080 31559852
Glomerular filtration rate decreased 12.12 11.76 19 131393 11846 31554086
Surgery 12.10 11.76 21 131391 12578 31553354
Enterococcal infection 12.10 11.76 11 131401 8720 31557212
Total cholesterol/HDL ratio increased 12.10 11.76 8 131404 163 31565769
Helplessness 12.07 11.76 6 131406 69 31565863
Transient ischaemic attack 12.01 11.76 55 131357 24001 31541931
Tendon rupture 12.00 11.76 6 131406 6513 31559419
Pemphigoid 11.97 11.76 10 131402 8261 31557671
Mental disability 11.96 11.76 5 131407 37 31565895
Selective mutism 11.92 11.76 6 131406 71 31565861
Foaming at mouth 11.91 11.76 15 131397 723 31565209
Exposure via body fluid 11.85 11.76 7 131405 116 31565816
Face oedema 11.83 11.76 16 131396 10600 31555332
Wrong patient received product 11.80 11.76 30 131382 2529 31563403
Tooth avulsion 11.79 11.76 4 131408 15 31565917
Conjunctivitis 11.79 11.76 11 131401 8612 31557320
Parkinson's disease 11.78 11.76 22 131390 1501 31564431
Pressure of speech 11.76 11.76 12 131400 458 31565474

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 5142.45 10.59 5392 279078 221743 70422231
Toxicity to various agents 4037.25 10.59 6201 278269 375971 70268003
Sopor 3518.45 10.59 1945 282525 29322 70614652
Drug abuse 3308.39 10.59 3486 280984 143770 70500204
Suicide attempt 3160.83 10.59 2589 281881 76921 70567053
Intentional overdose 2866.42 10.59 2685 281785 95750 70548224
Neuroleptic malignant syndrome 2644.04 10.59 1514 282956 24493 70619481
Overdose 1895.37 10.59 2833 281637 166912 70477062
Drug interaction 1789.61 10.59 4397 280073 377044 70266930
Intentional self-injury 1672.06 10.59 1221 283249 30429 70613545
Sedation 1366.80 10.59 1279 283191 45452 70598522
Somnolence 1358.88 10.59 2798 281672 212808 70431166
Coma 1262.16 10.59 1694 282776 90150 70553824
Dystonia 1199.46 10.59 829 283641 18877 70625097
Psychotic disorder 1176.44 10.59 1070 283400 36631 70607343
Agitation 1166.80 10.59 1645 282825 91730 70552244
Electrocardiogram QT prolonged 1149.90 10.59 1542 282928 81975 70561999
Tardive dyskinesia 1046.22 10.59 592 283878 9337 70634637
Dyskinesia 1038.74 10.59 1038 283432 40036 70603938
Extrapyramidal disorder 991.75 10.59 754 283716 19996 70623978
Schizophrenia 961.20 10.59 680 283790 16088 70627886
Suicidal ideation 922.92 10.59 1262 283208 68334 70575640
Depressed level of consciousness 906.10 10.59 1411 283059 86020 70557954
Aggression 891.84 10.59 1035 283435 47411 70596563
Akathisia 807.06 10.59 542 283928 11751 70632223
Mania 733.67 10.59 584 283886 16590 70627384
Serotonin syndrome 667.50 10.59 834 283636 41280 70602694
Muscle rigidity 652.67 10.59 565 283905 18085 70625889
Diarrhoea 648.64 10.59 1360 283110 781981 69861993
Delusion 645.33 10.59 568 283902 18597 70625377
Hallucination 634.26 10.59 1115 283355 75145 70568829
Parkinsonism 595.25 10.59 493 283977 14832 70629142
Depression 582.75 10.59 1939 282531 197035 70446939
Bradyphrenia 578.46 10.59 407 284063 9539 70634435
Blood prolactin abnormal 565.50 10.59 259 284211 2537 70641437
Dyspnoea 563.79 10.59 1428 283042 768632 69875342
Poisoning 559.48 10.59 565 283905 22057 70621917
Arthralgia 538.09 10.59 741 283729 502649 70141325
Gestational diabetes 519.30 10.59 315 284155 5686 70638288
Sexual dysfunction 518.02 10.59 327 284143 6354 70637620
Delirium 512.64 10.59 1005 283465 73609 70570365
Restlessness 506.32 10.59 729 283741 41399 70602575
Tachycardia 501.02 10.59 1586 282884 156960 70487014
Poisoning deliberate 494.80 10.59 465 284005 16595 70627379
Hallucination, auditory 475.80 10.59 470 284000 17858 70626116
Abnormal behaviour 457.76 10.59 628 283842 34081 70609893
Pain 455.83 10.59 1171 283299 627645 70016329
Anosognosia 445.48 10.59 222 284248 2663 70641311
Febrile neutropenia 445.45 10.59 133 284337 204185 70439789
Rheumatoid arthritis 444.51 10.59 314 284156 291491 70352483
Confusional state 441.35 10.59 2279 282191 282119 70361855
Altered state of consciousness 439.77 10.59 664 283806 39358 70604616
Psychomotor hyperactivity 436.78 10.59 415 284055 15018 70628956
Paranoia 435.23 10.59 436 284034 16852 70627122
Priapism 411.34 10.59 237 284233 3873 70640101
Bradykinesia 404.09 10.59 293 284177 7209 70636765
Disturbance in social behaviour 397.67 10.59 231 284239 3836 70640138
Intentional product misuse 395.08 10.59 940 283530 78655 70565319
Catatonia 393.98 10.59 298 284172 7835 70636139
Respiratory arrest 391.89 10.59 744 283726 53189 70590785
Rash 391.45 10.59 923 283547 509639 70134335
Diabetes mellitus 389.18 10.59 878 283592 70946 70573028
Fatigue 372.44 10.59 1873 282597 822446 69821528
Cardio-respiratory arrest 371.48 10.59 1064 283406 99613 70544361
Hypomania 340.44 10.59 243 284227 5829 70638145
Bezoar 340.06 10.59 172 284298 2134 70641840
Joint swelling 332.67 10.59 315 284155 252896 70391078
Tremor 329.82 10.59 1367 283103 154257 70489717
Cough 328.38 10.59 498 283972 324879 70319095
Mydriasis 327.51 10.59 363 284107 15790 70628184
Pneumonia 323.03 10.59 1265 283205 594967 70049007
Pain in extremity 322.64 10.59 511 283959 327571 70316403
Oculogyric crisis 320.17 10.59 174 284296 2524 70641450
Anxiety 319.16 10.59 1733 282737 218597 70425377
Malignant neoplasm progression 315.69 10.59 54 284416 121685 70522289
Metabolic disorder 315.03 10.59 260 284210 7780 70636194
Blood creatine phosphokinase increased 313.21 10.59 732 283738 60531 70583443
Nausea 312.38 10.59 2071 282399 850017 69793957
Bipolar disorder 310.64 10.59 252 284218 7356 70636618
Hyperprolactinaemia 307.58 10.59 202 284268 4211 70639763
Anaemia 303.61 10.59 736 283734 402687 70241287
Disease progression 297.14 10.59 128 284342 156544 70487430
Pruritus 294.90 10.59 588 283882 344972 70299002
Personality change 290.83 10.59 259 284211 8611 70635363
Restless legs syndrome 288.80 10.59 363 284107 18065 70625909
Speech disorder 271.37 10.59 616 283854 49964 70594010
Sinusitis 266.87 10.59 175 284295 169020 70474954
Drug hypersensitivity 266.35 10.59 400 284070 262059 70381915
Disorientation 263.88 10.59 662 283808 57261 70586713
Back pain 263.03 10.59 426 284044 270726 70373248
Loss of consciousness 260.97 10.59 1276 283194 154440 70489534
Sinus tachycardia 255.23 10.59 475 283995 33438 70610536
Nasopharyngitis 254.43 10.59 310 284160 221896 70422078
Metabolic syndrome 248.43 10.59 143 284327 2332 70641642
Cardiac failure congestive 245.41 10.59 118 284352 135339 70508635
Peripheral swelling 245.41 10.59 355 284115 236208 70407766
Rhabdomyolysis 241.64 10.59 889 283581 94871 70549103
Seizure 241.08 10.59 1375 283095 176587 70467387
Headache 239.63 10.59 1358 283112 579047 70064927
Irritability 234.03 10.59 491 283979 37734 70606240
Anticholinergic syndrome 231.38 10.59 146 284324 2834 70641140
Infection 227.92 10.59 307 284163 210478 70433496
Atrial fibrillation 225.29 10.59 244 284226 184104 70459870
Sepsis 221.73 10.59 401 284069 244144 70399830
Cardiac arrest 215.18 10.59 1233 283237 158601 70485373
Urinary retention 214.31 10.59 576 283894 51944 70592030
Obesity 214.14 10.59 385 284085 26386 70617588
Stubbornness 212.51 10.59 72 284398 280 70643694
Dysarthria 211.06 10.59 639 283831 61674 70582300
Obsessive-compulsive disorder 209.02 10.59 173 284297 5197 70638777
Drug withdrawal syndrome 208.22 10.59 427 284043 32288 70611686
Suspected suicide 208.15 10.59 215 284255 8619 70635355
Miosis 205.58 10.59 268 284202 13833 70630141
Disturbance in attention 204.62 10.59 499 283971 42395 70601579
Pyrexia 203.75 10.59 1512 282958 605440 70038534
Herpes zoster 203.74 10.59 46 284424 85189 70558785
Neuropathy peripheral 203.14 10.59 129 284341 126767 70517207
Galactorrhoea 202.87 10.59 141 284329 3237 70640737
Blood prolactin increased 198.50 10.59 145 284325 3609 70640365
Type 2 diabetes mellitus 197.84 10.59 501 283969 43579 70600395
Cogwheel rigidity 195.11 10.59 131 284339 2837 70641137
Exposure during pregnancy 194.78 10.59 782 283688 86935 70557039
Psychomotor retardation 194.62 10.59 169 284301 5429 70638545
Infusion related reaction 193.67 10.59 308 284162 197226 70446748
Thinking abnormal 191.40 10.59 239 284231 11812 70632162
Prescribed overdose 190.06 10.59 369 284101 26812 70617162
Plasma cell myeloma 184.26 10.59 35 284435 73166 70570808
Psychomotor skills impaired 183.62 10.59 146 284324 4138 70639836
Hallucination, visual 182.11 10.59 379 284091 28958 70615016
Psychiatric decompensation 175.46 10.59 123 284347 2864 70641110
Urticaria 173.67 10.59 240 284230 162809 70481165
Hypersensitivity 172.04 10.59 420 284050 229392 70414582
Schizoaffective disorder 171.97 10.59 105 284365 1918 70642056
Emotional poverty 171.49 10.59 76 284394 684 70643290
Coma scale abnormal 169.04 10.59 185 284285 7931 70636043
Haemoglobin decreased 168.95 10.59 356 284114 204803 70439171
Antipsychotic drug level increased 166.85 10.59 153 284317 5287 70638687
Treatment noncompliance 162.81 10.59 483 283987 46091 70597883
Platelet count decreased 162.59 10.59 291 284179 177931 70466043
Labour complication 162.48 10.59 41 284429 31 70643943
Stomatitis 161.55 10.59 166 284304 128345 70515629
Interstitial lung disease 161.35 10.59 111 284359 104574 70539400
Salivary hypersecretion 158.66 10.59 226 284244 12699 70631275
Malaise 156.02 10.59 1056 283414 431876 70212098
Mucosal inflammation 153.62 10.59 41 284429 67809 70576165
Cognitive disorder 152.13 10.59 564 283906 60392 70583582
Gastrointestinal haemorrhage 151.66 10.59 197 284273 137211 70506763
Sleep-related eating disorder 150.71 10.59 68 284402 641 70643333
Hallucinations, mixed 150.19 10.59 155 284315 6207 70637767
Anger 149.99 10.59 248 284222 15884 70628090
Somnambulism 149.88 10.59 142 284328 5118 70638856
Erythema 149.12 10.59 365 284105 199198 70444776
Acute kidney injury 147.98 10.59 1206 283264 473418 70170556
Derealisation 146.89 10.59 86 284384 1450 70642524
Persecutory delusion 146.31 10.59 131 284339 4386 70639588
Mental disorder 146.00 10.59 339 284131 27901 70616073
Abdominal discomfort 145.64 10.59 412 284058 214246 70429728
Hypokinesia 144.94 10.59 255 284215 17177 70626797
Apathy 142.92 10.59 206 284264 11702 70632272
Influenza 141.63 10.59 148 284322 113552 70530422
Suicidal behaviour 139.29 10.59 108 284362 2948 70641026
Substance abuse 138.82 10.59 184 284286 9653 70634321
Drug intolerance 138.25 10.59 454 284016 225233 70418741
Respiratory depression 137.16 10.59 306 284164 24525 70619449
Myocardial infarction 137.01 10.59 303 284167 171342 70472632
Hyperreflexia 136.85 10.59 159 284311 7283 70636691
Myoclonus 135.84 10.59 316 284154 26039 70617935
Withdrawal syndrome 135.44 10.59 305 284165 24599 70619375
Unresponsive to stimuli 134.22 10.59 486 283984 51445 70592529
Pneumonia aspiration 134.03 10.59 550 283920 61739 70582235
Swelling 132.26 10.59 356 284114 188183 70455791
Hyperthermia 131.09 10.59 238 284232 16433 70627541
Hyperammonaemic encephalopathy 130.53 10.59 122 284348 4321 70639653
Pleural effusion 130.33 10.59 207 284263 132657 70511317
Synovitis 129.94 10.59 198 284272 129030 70514944
Euphoric mood 129.73 10.59 149 284321 6740 70637234
Pancytopenia 129.64 10.59 256 284214 150851 70493123
Pleurothotonus 128.77 10.59 93 284377 2273 70641701
Injection site erythema 128.31 10.59 66 284404 72858 70571116
Diabetic coma 128.00 10.59 72 284398 1121 70642853
Chest discomfort 127.56 10.59 188 284282 124193 70519781
Drug screen positive 126.66 10.59 136 284334 5704 70638270
Mood altered 125.50 10.59 232 284238 16243 70627731
Arthritis 124.92 10.59 125 284345 97855 70546119
Thrombocytopenia 122.29 10.59 518 283952 238592 70405382
Weight increased 121.60 10.59 1496 282974 240835 70403139
Bipolar I disorder 119.79 10.59 82 284388 1835 70642139
Stupor 119.58 10.59 139 284331 6370 70637604
Arthropathy 118.84 10.59 266 284204 149791 70494183
COVID-19 118.37 10.59 150 284320 105607 70538367
Posture abnormal 117.88 10.59 105 284365 3491 70640483
Epistaxis 117.55 10.59 143 284327 102484 70541490
Gastrointestinal disorder 117.51 10.59 150 284320 105277 70538697
Skin ulcer 117.04 10.59 25 284445 48120 70595854
Mental impairment 116.69 10.59 231 284239 17024 70626950
Cellulitis 116.35 10.59 135 284335 98793 70545181
Mood swings 115.56 10.59 238 284232 18048 70625926
Depersonalisation/derealisation disorder 114.54 10.59 77 284393 1671 70642303
Alopecia 114.29 10.59 410 284060 198080 70445894
Ascites 113.20 10.59 65 284405 67482 70576492
Asthenia 111.39 10.59 1236 283234 456430 70187544
Dyspnoea exertional 110.78 10.59 91 284379 78339 70565635
Depressed mood 110.63 10.59 407 284063 43413 70600561
Hyperkalaemia 110.38 10.59 160 284310 106431 70537543
Myocarditis 109.93 10.59 237 284233 18556 70625418
Cytomegalovirus infection 109.04 10.59 15 284455 39743 70604231
Drug dependence 108.34 10.59 363 284107 36958 70607016
Injection site pain 108.18 10.59 191 284279 117428 70526546
Hypothermia 107.31 10.59 248 284222 20346 70623628
Flushing 106.86 10.59 103 284367 82069 70561905
Orthostatic hypertension 104.53 10.59 53 284417 661 70643313
Electrocardiogram QRS complex prolonged 103.87 10.59 160 284310 9646 70634328
Urinary tract infection 103.41 10.59 580 283890 248189 70395785
Chills 103.33 10.59 271 284199 144515 70499459
Major depression 102.42 10.59 148 284322 8426 70635548
Psychiatric symptom 101.12 10.59 129 284341 6515 70637459
Diverticulitis 100.78 10.59 22 284448 41712 70602262
Logorrhoea 100.32 10.59 102 284368 4012 70639962
Faecaloma 100.31 10.59 163 284307 10288 70633686
Decreased appetite 100.15 10.59 763 283707 304017 70339957
Chest pain 100.05 10.59 594 283876 250666 70393308
Psoriasis 98.77 10.59 151 284319 98282 70545692
Social avoidant behaviour 98.48 10.59 107 284363 4549 70639425
Drooling 98.05 10.59 115 284355 5321 70638653
Homicidal ideation 97.15 10.59 91 284379 3232 70640742
Dementia 97.02 10.59 251 284219 22114 70621860
Embolism venous 96.81 10.59 97 284373 3748 70640226
Nightmare 96.47 10.59 249 284221 21907 70622067
Clonus 95.87 10.59 122 284348 6146 70637828
Osteonecrosis of jaw 94.29 10.59 24 284446 40978 70602996
Blood pressure increased 94.15 10.59 412 284058 188105 70455869
Basal cell carcinoma 94.12 10.59 12 284458 33686 70610288
Feeling of despair 94.12 10.59 81 284389 2570 70641404
Depressive symptom 94.11 10.59 110 284360 5071 70638903
Anaphylactic reaction 94.02 10.59 97 284373 74877 70569097
Myelosuppression 93.98 10.59 7 284463 30138 70613836
Insomnia 93.91 10.59 1308 283162 216498 70427476
Pneumocystis jirovecii pneumonia 93.74 10.59 7 284463 30075 70613899
Productive cough 93.09 10.59 106 284364 78231 70565743
Behaviour disorder 92.64 10.59 112 284358 5352 70638622
Dissociation 92.14 10.59 89 284381 3287 70640687
Thrombosis 91.83 10.59 100 284370 75305 70568669
Psychotic symptom 91.69 10.59 77 284393 2361 70641613
Hyperkinesia 90.81 10.59 79 284391 2544 70641430
Neoplasm progression 90.51 10.59 34 284436 45194 70598780
Abdominal pain 90.04 10.59 907 283563 341220 70302754
Medication error 90 10.59 459 284011 56453 70587521
Coronary artery disease 89.58 10.59 72 284398 62664 70581310
Oedema peripheral 87.77 10.59 545 283925 227546 70416428
Accidental overdose 87.64 10.59 325 284145 34796 70609178
Exposure via ingestion 87.03 10.59 103 284367 4812 70639162
Bone marrow failure 86.75 10.59 44 284426 48966 70595008
Depression suicidal 86.22 10.59 80 284390 2807 70641167
Hypotension 85.67 10.59 2175 282295 402206 70241768
Bronchitis 85.53 10.59 217 284253 117026 70526948
Tearfulness 85.28 10.59 103 284367 4917 70639057
Sleep disorder 84.92 10.59 525 283945 69347 70574627
Impulse-control disorder 84.61 10.59 63 284407 1616 70642358
Akinesia 84.43 10.59 82 284388 3049 70640925
Colitis 84.13 10.59 79 284391 63735 70580239
Acute myeloid leukaemia 84.08 10.59 12 284458 30928 70613046
Bone pain 83.61 10.59 50 284420 50772 70593202
Lower respiratory tract infection 83.30 10.59 205 284265 111708 70532266
Cardiac failure 82.93 10.59 296 284174 143245 70500729
Pneumonitis 82.64 10.59 59 284411 54538 70589436
Palmar-plantar erythrodysaesthesia syndrome 81.57 10.59 12 284458 30235 70613739
Gastric pH decreased 80.35 10.59 46 284424 742 70643232
Liver injury 80.25 10.59 352 284118 40683 70603291
Blood triglycerides increased 79.52 10.59 215 284255 19449 70624525
Granulocytopenia 78.68 10.59 148 284322 10499 70633475
Prescribed underdose 77.80 10.59 225 284245 21160 70622814
Injection site pruritus 77.59 10.59 30 284440 39180 70604794
Aspiration 77.33 10.59 199 284271 17476 70626498
Upper respiratory tract infection 77.25 10.59 124 284346 79150 70564824
Disinhibition 77.05 10.59 68 284402 2233 70641741
Nasal congestion 76.80 10.59 90 284380 65582 70578392
Asthma 76.70 10.59 239 284231 120554 70523420
Slow speech 75.85 10.59 66 284404 2126 70641848
Renal failure 75.75 10.59 446 284024 188624 70455350
Weight decreased 75.64 10.59 838 283632 309650 70334324
Torticollis 75.40 10.59 66 284404 2143 70641831
Renal impairment 75.29 10.59 309 284161 143628 70500346
Generalised tonic-clonic seizure 75.20 10.59 349 284121 41312 70602662
Musculoskeletal pain 74.91 10.59 156 284314 90171 70553803
Stereotypy 74.78 10.59 46 284424 852 70643122
Tic 74.49 10.59 72 284398 2661 70641313
Rhinorrhoea 74.40 10.59 94 284376 66277 70577697
Disorganised speech 74.25 10.59 60 284410 1741 70642233
Therapeutic product effect decreased 74.20 10.59 308 284162 142710 70501264
On and off phenomenon 73.32 10.59 72 284398 2714 70641260
Injection site swelling 73.07 10.59 41 284429 43116 70600858
Rash pruritic 72.94 10.59 87 284383 62904 70581070
Fluid retention 72.91 10.59 88 284382 63297 70580677
Acute psychosis 72.56 10.59 84 284386 3832 70640142
Bruxism 72.50 10.59 82 284388 3647 70640327
Contraindicated product administered 72.28 10.59 286 284184 134326 70509648
Impulsive behaviour 72.16 10.59 71 284399 2683 70641291
Impaired healing 71.85 10.59 117 284353 74257 70569717
Septic shock 70.64 10.59 223 284247 112035 70531939
Panic attack 70.38 10.59 222 284248 21897 70622077
Affect lability 70.02 10.59 137 284333 10009 70633965
Muscle twitching 69.63 10.59 206 284264 19621 70624353
Accidental death 69.37 10.59 82 284388 3826 70640148
Antipsychotic drug level above therapeutic 69.31 10.59 60 284410 1919 70642055
Enuresis 68.73 10.59 71 284399 2846 70641128
Alcohol abuse 68.20 10.59 93 284377 5014 70638960
Tension 67.44 10.59 82 284388 3942 70640032
Acute myocardial infarction 67.33 10.59 118 284352 72769 70571205
Visceral congestion 67.16 10.59 42 284428 802 70643172
Pulmonary arterial hypertension 66.92 10.59 24 284446 32831 70611143
Long QT syndrome 66.64 10.59 94 284376 5233 70638741
Neutropenic sepsis 66.62 10.59 10 284460 24820 70619154
Colitis ischaemic 65.85 10.59 163 284307 13974 70630000
Mutism 65.84 10.59 60 284410 2056 70641918
Oromandibular dystonia 65.69 10.59 43 284427 891 70643083
Dyspepsia 65.64 10.59 164 284306 88913 70555061
Myelodysplastic syndrome 65.54 10.59 19 284451 29766 70614208
Red blood cell sedimentation rate increased 65.01 10.59 37 284433 38605 70605369
Coma blister 64.42 10.59 27 284443 209 70643765
Nephrolithiasis 64.26 10.59 57 284413 47266 70596708
Tachyphrenia 64.02 10.59 57 284413 1894 70642080
Myalgia 63.61 10.59 403 284067 167489 70476485
Distributive shock 62.99 10.59 60 284410 2177 70641797
Vomiting 62.92 10.59 1855 282615 591256 70052718
Hyperammonaemia 62.73 10.59 132 284338 10161 70633813
Electrocardiogram QRS complex shortened 62.57 10.59 37 284433 636 70643338
Bronchopulmonary aspergillosis 62.39 10.59 6 284464 20996 70622978
Amenorrhoea 62.37 10.59 105 284365 6825 70637149
Oropharyngeal pain 62.24 10.59 189 284281 96121 70547853
Myoglobin urine present 62.19 10.59 38 284432 695 70643279
Malignant catatonia 61.82 10.59 32 284438 418 70643556
Drug level increased 61.82 10.59 300 284170 36169 70607805
Hypervolaemia 61.29 10.59 42 284428 39664 70604310
Antipsychotic drug level below therapeutic 61.23 10.59 42 284428 943 70643031
Cerebrovascular accident 60.38 10.59 333 284137 143137 70500837
Attention deficit hyperactivity disorder 60.32 10.59 67 284403 2920 70641054
Product substitution issue 60 10.59 187 284283 18326 70625648
Cytokine release syndrome 59.89 10.59 16 284454 26451 70617523
Leukopenia 59.63 10.59 672 283798 105888 70538086
Breast cancer 59.55 10.59 30 284440 33519 70610455
Aspergillus infection 59.15 10.59 3 284467 17865 70626109
Torsade de pointes 58.72 10.59 183 284287 17933 70626041
Hypersomnia 58.53 10.59 200 284270 20564 70623410
Localised infection 58.33 10.59 30 284440 33128 70610846
Haemophagocytic lymphohistiocytosis 57.23 10.59 6 284464 19606 70624368
Inflammation 57.05 10.59 146 284324 78519 70565455
Dry skin 56.87 10.59 85 284385 55846 70588128
Schizophreniform disorder 56.54 10.59 22 284448 137 70643837
Stoma site discharge 56.45 10.59 51 284419 1728 70642246
Full blood count abnormal 56.19 10.59 33 284437 33845 70610129
Amnesia 56.09 10.59 380 284090 51775 70592199
Abulia 56.08 10.59 39 284431 896 70643078
Clostridium difficile colitis 56.03 10.59 23 284447 28973 70615001
Circulatory collapse 56.01 10.59 286 284184 35188 70608786
Hypertension 55.12 10.59 845 283625 295188 70348786
Prostate cancer 55.11 10.59 28 284442 31135 70612839
Urinary hesitation 55.00 10.59 71 284399 3628 70640346
Osteonecrosis 54.96 10.59 24 284446 29136 70614838
Gastrooesophageal reflux disease 54.69 10.59 184 284286 90655 70553319
Transplant rejection 54.49 10.59 5 284465 18166 70625808
Hypotonia 54.42 10.59 136 284334 11729 70632245
Self-injurious ideation 54.29 10.59 67 284403 3271 70640703
Polydipsia 54.25 10.59 91 284379 5897 70638077
Dysphoria 54.25 10.59 78 284392 4420 70639554
Brugada syndrome 54.06 10.59 41 284429 1082 70642892
Pain in jaw 53.72 10.59 55 284415 42614 70601360
Menstrual disorder 53.59 10.59 69 284401 3517 70640457
Incoherent 53.30 10.59 101 284369 7205 70636769
Incontinence 53.24 10.59 143 284327 12885 70631089
Electrocardiogram abnormal 53.07 10.59 154 284316 14510 70629464
Treatment failure 53.06 10.59 349 284121 143793 70500181
Sexually inappropriate behaviour 52.34 10.59 30 284440 485 70643489
Abnormal weight gain 52.31 10.59 55 284415 2251 70641723
Sleep disorder due to general medical condition, insomnia type 52.28 10.59 40 284430 35692 70608282
Memory impairment 52.18 10.59 585 283885 92056 70551918
Tumour lysis syndrome 52.10 10.59 11 284459 21349 70622625
Neck pain 52.06 10.59 119 284351 66538 70577436
Pulmonary hypertension 52.06 10.59 66 284404 46470 70597504
Hypocalcaemia 51.89 10.59 62 284408 44797 70599177
Parkinsonian gait 51.73 10.59 36 284434 828 70643146
Hypertriglyceridaemia 51.69 10.59 133 284337 11678 70632296
Poverty of speech 51.66 10.59 31 284439 548 70643426
Full blood count decreased 51.28 10.59 16 284454 23902 70620072
Rectal haemorrhage 51.03 10.59 118 284352 65713 70578261
Psychotic behaviour 50.98 10.59 39 284431 1043 70642931
Alcohol interaction 50.80 10.59 77 284393 4576 70639398
Epilepsy 50.68 10.59 297 284173 38487 70605487
Dehydration 50.52 10.59 622 283848 225520 70418454
Drug ineffective 50.46 10.59 3173 281297 936579 69707395
Chronic obstructive pulmonary disease 50.43 10.59 152 284318 77489 70566485
Homicide 50.41 10.59 40 284430 1130 70642844
Inappropriate affect 50.32 10.59 43 284427 1351 70642623
Urinary incontinence 50.23 10.59 291 284179 37551 70606423
Ataxia 49.92 10.59 205 284265 23012 70620962
Fungal infection 49.83 10.59 46 284424 37421 70606553
Haemoptysis 49.64 10.59 81 284389 51371 70592603
Osteomyelitis 49.63 10.59 30 284440 30288 70613686
Anaphylactic shock 49.31 10.59 35 284435 32455 70611519
Language disorder 49.07 10.59 60 284410 2901 70641073
Increased appetite 49.04 10.59 122 284348 10491 70633483
Emotional disorder 48.93 10.59 140 284330 13086 70630888
Haematuria 48.44 10.59 115 284355 63458 70580516
Hypercalcaemia 48.42 10.59 40 284430 34345 70609629
Bundle branch block right 48.01 10.59 121 284349 10489 70633485
Muscular weakness 47.43 10.59 342 284128 137994 70505980
Alcohol poisoning 47.33 10.59 72 284398 4293 70639681
Anticonvulsant drug level above therapeutic 47.31 10.59 38 284432 1093 70642881
Suspiciousness 47.29 10.59 30 284440 588 70643386
Feeling guilty 47.22 10.59 34 284436 827 70643147
Affective disorder 46.85 10.59 97 284373 7382 70636592
Injection site bruising 46.78 10.59 50 284420 37982 70605992
Bacteraemia 46.59 10.59 30 284440 29279 70614695
Stoma site erythema 46.44 10.59 41 284429 1347 70642627
Insurance issue 46.39 10.59 65 284405 3596 70640378
Hypertonia 46.38 10.59 89 284381 6409 70637565
Metastases to bone 46.16 10.59 16 284454 22360 70621614
Abdominal pain upper 46.12 10.59 525 283945 193077 70450897
Slow response to stimuli 46.01 10.59 45 284425 1688 70642286
Pseudomonas infection 45.88 10.59 10 284460 18984 70624990
Angioedema 45.74 10.59 127 284343 66483 70577491
Metastases to lung 45.72 10.59 6 284464 16478 70627496
Electrocardiogram QT interval abnormal 45.63 10.59 23 284447 283 70643691
Apraxia 45.49 10.59 55 284415 2628 70641346
Oppositional defiant disorder 45.41 10.59 27 284443 469 70643505
Gastric disorder 45.41 10.59 40 284430 33282 70610692
Rabbit syndrome 45.22 10.59 24 284446 331 70643643
Self esteem decreased 44.77 10.59 34 284436 899 70643075
Sympathomimetic effect 44.75 10.59 15 284455 56 70643918
Colitis ulcerative 44.70 10.59 42 284428 33881 70610093
Progressive multifocal leukoencephalopathy 44.66 10.59 11 284459 19203 70624771
Negativism 44.59 10.59 32 284438 774 70643200
Blood creatinine increased 44.57 10.59 363 284107 142638 70501336
Reduced facial expression 44.50 10.59 51 284419 2301 70641673
Freezing phenomenon 44.45 10.59 43 284427 1591 70642383
Haemorrhage 44.39 10.59 179 284291 83636 70560338
Tenosynovitis 44.28 10.59 3 284467 13973 70630001
Bradypnoea 44.28 10.59 79 284391 5380 70638594
Blood pressure systolic increased 44.09 10.59 103 284367 57156 70586818
Device expulsion 44.05 10.59 17 284453 22229 70621745
Judgement impaired 43.87 10.59 36 284434 1068 70642906
Conversion disorder 43.83 10.59 44 284426 1704 70642270
Neoplasm malignant 43.67 10.59 31 284439 28743 70615231
Mental status changes 43.38 10.59 415 284055 62686 70581288
Angina pectoris 43.18 10.59 80 284390 48303 70595671
Trismus 43.00 10.59 75 284395 5016 70638958
Anaemia of pregnancy 42.99 10.59 15 284455 65 70643909
Pyramidal tract syndrome 42.83 10.59 27 284443 523 70643451
Hyperphagia 42.71 10.59 50 284420 2309 70641665
Sudden cardiac death 42.62 10.59 73 284397 4812 70639162
Viral infection 42.37 10.59 55 284415 38336 70605638
Pulmonary mass 42.28 10.59 26 284444 26007 70617967
Sinus congestion 42.26 10.59 9 284461 17364 70626610
Device related infection 42.23 10.59 40 284430 32145 70611829
Hyperhidrosis 42.13 10.59 752 283718 130834 70513140
Dependence 42.06 10.59 49 284421 2251 70641723
Stoma site hypergranulation 42.04 10.59 24 284446 385 70643589
Infarction 41.86 10.59 67 284403 4175 70639799
Gout 41.70 10.59 20 284450 22986 70620988
Food interaction 41.61 10.59 41 284429 1552 70642422
Resting tremor 41.59 10.59 39 284431 1387 70642587
Blood cholesterol increased 41.54 10.59 419 284051 64185 70579789
Systemic lupus erythematosus 41.52 10.59 239 284231 101663 70542311
Osteoarthritis 41.42 10.59 155 284315 73992 70569982
Tubulointerstitial nephritis 41.23 10.59 43 284427 33033 70610941
Jealous delusion 41.13 10.59 21 284449 266 70643708
Excessive eye blinking 41.11 10.59 39 284431 1408 70642566
Immunodeficiency 40.90 10.59 10 284460 17545 70626429
Oral pain 40.69 10.59 34 284436 29032 70614942
Injection site reaction 40.57 10.59 87 284383 49765 70594209
Refusal of examination 40.52 10.59 18 284452 163 70643811
Metastases to liver 40.44 10.59 27 284443 25851 70618123
Proteinuria 40.34 10.59 35 284435 29339 70614635
Dysphonia 40.30 10.59 88 284382 50012 70593962
Psychosexual disorder 40.16 10.59 16 284454 107 70643867
Chronic kidney disease 40.03 10.59 119 284351 60938 70583036
Blunted affect 39.61 10.59 24 284446 432 70643542
Postural tremor 39.45 10.59 27 284443 604 70643370
Right ventricular failure 39.41 10.59 20 284450 22254 70621720
Haematochezia 39.39 10.59 155 284315 72926 70571048
Crying 39.30 10.59 179 284291 21020 70622954
Hypoacusis 39.30 10.59 31 284439 27238 70616736
Pyromania 39.16 10.59 11 284459 18 70643956
Hot flush 39.14 10.59 88 284382 49496 70594478
Product dose omission issue 39.01 10.59 625 283845 216843 70427131
Contusion 38.99 10.59 327 284143 127709 70516265
Diet refusal 38.87 10.59 30 284440 813 70643161
Rash maculo-papular 38.85 10.59 91 284379 50454 70593520
Therapy interrupted 38.60 10.59 26 284444 24776 70619198
Surgery 38.50 10.59 38 284432 29951 70614023
Troponin increased 38.36 10.59 150 284320 16464 70627510
Nodule 38.33 10.59 16 284454 19953 70624021
Self-medication 38.24 10.59 66 284404 4377 70639597
Status epilepticus 38.20 10.59 197 284273 24329 70619645
Upper gastrointestinal haemorrhage 38.05 10.59 57 284413 37420 70606554
Nephrogenic diabetes insipidus 37.88 10.59 43 284427 1920 70642054
Haematotoxicity 37.87 10.59 5 284465 13669 70630305
Screaming 37.61 10.59 59 284411 3613 70640361
Floppy iris syndrome 37.50 10.59 21 284449 324 70643650
Lymphadenopathy 37.38 10.59 88 284382 48703 70595271
Drug diversion 37.14 10.59 34 284436 1172 70642802
Sudden death 36.94 10.59 175 284295 20889 70623085
Amniotic fluid volume increased 36.89 10.59 16 284454 136 70643838
Multiple organ dysfunction syndrome 36.84 10.59 269 284201 108246 70535728
Multiple drug therapy 36.53 10.59 54 284416 3138 70640836
Feeling of body temperature change 36.53 10.59 69 284401 4910 70639064
Pathogen resistance 36.43 10.59 5 284465 13274 70630700
Malignant melanoma 36.38 10.59 6 284464 13894 70630080
Action tremor 36.17 10.59 22 284448 399 70643575
Mouth ulceration 36.10 10.59 51 284419 34298 70609676
Sluggishness 35.97 10.59 76 284394 5867 70638107
International normalised ratio increased 35.82 10.59 184 284286 80542 70563432
Lung neoplasm malignant 35.81 10.59 28 284442 24714 70619260
Potentiating drug interaction 35.79 10.59 92 284378 8072 70635902
Paradoxical drug reaction 35.77 10.59 81 284389 6555 70637419
Colon cancer 35.66 10.59 7 284463 14299 70629675
Blepharospasm 35.59 10.59 59 284411 3786 70640188
Throat irritation 35.55 10.59 54 284416 35250 70608724
Faeces discoloured 35.55 10.59 33 284437 26776 70617198
Diabetic ketoacidosis 35.32 10.59 232 284238 31280 70612694
Dystonic tremor 35.32 10.59 17 284453 188 70643786
Pneumothorax 35.25 10.59 31 284439 25815 70618159
Gastroenteritis 35.19 10.59 44 284426 31169 70612805
Oropharyngeal spasm 35.19 10.59 20 284450 318 70643656
Dysgeusia 35.03 10.59 93 284377 49409 70594565
Discomfort 35.01 10.59 263 284207 105173 70538801
Gambling disorder 34.96 10.59 41 284429 1897 70642077
Pancreatitis 34.95 10.59 395 284075 62273 70581701
Type 1 diabetes mellitus 34.79 10.59 77 284393 6137 70637837
Tenderness 34.70 10.59 21 284449 21189 70622785
Tendonitis 34.68 10.59 23 284447 22099 70621875
Squamous cell carcinoma 34.65 10.59 8 284462 14596 70629378
Decreased eye contact 34.60 10.59 28 284442 814 70643160
Libido increased 34.48 10.59 40 284430 1829 70642145
Bladder cancer 34.43 10.59 13 284457 17229 70626745
Adjustment disorder with mixed anxiety and depressed mood 34.38 10.59 13 284457 74 70643900
Alcoholism 34.36 10.59 63 284407 4382 70639592
White blood cell count decreased 34.30 10.59 478 283992 169663 70474311
Diffuse large B-cell lymphoma 34.24 10.59 6 284464 13296 70630678
H1N1 influenza 34.18 10.59 45 284425 2345 70641629
Loss of libido 34.15 10.59 46 284424 2451 70641523
Cystitis 34.12 10.59 87 284383 46854 70597120
Wrong patient received product 34.01 10.59 63 284407 4417 70639557
Tongue spasm 33.95 10.59 13 284457 77 70643897
Ulcer 33.80 10.59 32 284438 25722 70618252
Electrocardiogram repolarisation abnormality 33.46 10.59 40 284430 1889 70642085
Injection site rash 33.40 10.59 12 284458 16398 70627576
Melaena 33.34 10.59 115 284355 56240 70587734
Arrhythmia 33.20 10.59 358 284112 55785 70588189
Tongue biting 33.16 10.59 39 284431 1810 70642164
Pulmonary fibrosis 33.11 10.59 54 284416 34256 70609718
Lymphocyte count decreased 32.98 10.59 79 284391 43460 70600514
Oxygen saturation decreased 32.96 10.59 303 284167 116126 70527848
Urine osmolarity increased 32.94 10.59 18 284452 264 70643710
Gastritis 32.92 10.59 82 284388 44509 70599465
Dementia with Lewy bodies 32.75 10.59 26 284444 735 70643239
Compartment syndrome 32.70 10.59 62 284408 4424 70639550
Delusional disorder, unspecified type 32.69 10.59 26 284444 737 70643237
Feelings of worthlessness 32.66 10.59 22 284448 479 70643495
Hypogammaglobulinaemia 32.49 10.59 4 284466 11534 70632440
Hypomagnesaemia 32.46 10.59 72 284398 40692 70603282
Immunosuppression 32.32 10.59 4 284466 11488 70632486
Pulmonary toxicity 32.30 10.59 3 284467 10795 70633179
Burning mouth syndrome 32.27 10.59 22 284448 489 70643485
Adrenal insufficiency 32.26 10.59 32 284438 25163 70618811
Toxic epidermal necrolysis 32.22 10.59 69 284401 39488 70604486
Squamous cell carcinoma of skin 32.15 10.59 6 284464 12706 70631268
Decreased interest 32.12 10.59 53 284417 3388 70640586
Sinus disorder 32.11 10.59 18 284452 18941 70625033
Anxiolytic therapy 32.03 10.59 11 284459 45 70643929
Drug therapy enhancement 32.03 10.59 11 284459 45 70643929
Bone disorder 32.01 10.59 15 284455 17475 70626499
Blister 31.86 10.59 254 284216 100272 70543702
Acute generalised exanthematous pustulosis 31.78 10.59 11 284459 15386 70628588
Transfusion 31.73 10.59 18 284452 18818 70625156
Penis injury 31.69 10.59 14 284456 125 70643849
Osteoporosis 31.57 10.59 96 284374 48811 70595163
Herbal interaction 31.51 10.59 21 284449 449 70643525
Hand deformity 31.51 10.59 210 284260 86272 70557702
Nuchal rigidity 31.50 10.59 29 284441 1007 70642967
Hypersexuality 31.46 10.59 35 284435 1528 70642446
Coagulopathy 31.46 10.59 53 284417 33196 70610778
Brain injury 31.46 10.59 104 284366 10513 70633461
Respiratory tract infection 31.27 10.59 78 284392 42320 70601654
Immune reconstitution inflammatory syndrome 31.05 10.59 7 284463 12983 70630991
Ejection fraction decreased 31.03 10.59 47 284423 30715 70613259
Flight of ideas 30.77 10.59 25 284445 731 70643243
Persistent genital arousal disorder 30.77 10.59 18 284452 303 70643671
Meconium in amniotic fluid 30.67 10.59 12 284458 76 70643898
Accidental poisoning 30.61 10.59 35 284435 1575 70642399
Congestive cardiomyopathy 30.58 10.59 105 284365 10821 70633153
Necrotising colitis 30.54 10.59 28 284442 967 70643007
Neuralgia 30.53 10.59 42 284428 28561 70615413
Enteritis 30.50 10.59 7 284463 12824 70631150
Borderline personality disorder 30.34 10.59 26 284444 820 70643154
Otospondylomegaepiphyseal dysplasia 30.33 10.59 10 284460 35 70643939
Hypoaesthesia 30.25 10.59 434 284036 153305 70490669
Staring 30.22 10.59 43 284427 2413 70641561
Hangover 30.16 10.59 38 284432 1895 70642079
Gastroenteritis viral 30.15 10.59 25 284445 21430 70622544
Thrombotic microangiopathy 30.15 10.59 17 284453 17831 70626143
Impaired self-care 30.13 10.59 42 284428 2312 70641662
Merycism 29.81 10.59 16 284454 226 70643748
Post-traumatic stress disorder 29.80 10.59 59 284411 4348 70639626
Gastric ulcer 29.78 10.59 51 284419 31739 70612235
Illusion 29.76 10.59 35 284435 1624 70642350
Diabetes insipidus 29.75 10.59 61 284409 4610 70639364
Physical assault 29.74 10.59 34 284436 1530 70642444
Refusal of treatment by patient 29.74 10.59 88 284382 8382 70635592
Eye movement disorder 29.73 10.59 81 284389 7359 70636615
Lung disorder 29.37 10.59 161 284309 69323 70574651
Withdrawal arrhythmia 29.29 10.59 10 284460 40 70643934
Atrioventricular block first degree 29.10 10.59 108 284362 11565 70632409
Ear pain 28.98 10.59 41 284429 27558 70616416
Inappropriate antidiuretic hormone secretion 28.97 10.59 176 284294 23100 70620874
Skin lesion 28.96 10.59 70 284400 38390 70605584
Grimacing 28.95 10.59 23 284447 651 70643323
Joint stiffness 28.95 10.59 61 284409 35115 70608859
Metastases to central nervous system 28.93 10.59 12 284458 15022 70628952
Renal cancer 28.92 10.59 6 284464 11790 70632184
Haemorrhoids 28.92 10.59 36 284434 25552 70618422
Blood glucose increased 28.65 10.59 576 283894 102406 70541568
Stoma site inflammation 28.61 10.59 22 284448 593 70643381
Irritable bowel syndrome 28.59 10.59 106 284364 50744 70593230
Angina unstable 28.53 10.59 14 284456 15879 70628095
Negative thoughts 28.51 10.59 31 284439 1319 70642655
Binge eating 28.48 10.59 20 284450 467 70643507
Antipsychotic drug level decreased 28.46 10.59 28 284442 1058 70642916
Injection site urticaria 28.37 10.59 6 284464 11632 70632342
Convulsive threshold lowered 28.36 10.59 26 284444 898 70643076
Injection site warmth 28.32 10.59 10 284460 13815 70630159
Uveitis 28.32 10.59 12 284458 14833 70629141
Staphylococcal infection 28.31 10.59 114 284356 53290 70590684
Antidepressant drug level above therapeutic 28.23 10.59 22 284448 605 70643369
Excessive masturbation 28.20 10.59 11 284459 69 70643905
Social anxiety disorder 28.19 10.59 20 284450 475 70643499
Delusional disorder, persecutory type 28.08 10.59 19 284451 417 70643557
Parkinsonian rest tremor 28.06 10.59 16 284454 256 70643718
Autonomic nervous system imbalance 28.03 10.59 57 284413 4282 70639692
Protein C increased 27.98 10.59 12 284458 99 70643875
Ear infection 27.90 10.59 44 284426 28292 70615682
Pulmonary haemorrhage 27.82 10.59 10 284460 13663 70630311
Peripartum cardiomyopathy 27.72 10.59 13 284457 135 70643839
Pressure of speech 27.71 10.59 27 284443 1008 70642966
Schizoaffective disorder bipolar type 27.58 10.59 14 284456 175 70643799
Skin exfoliation 27.58 10.59 101 284369 48525 70595449
Flatulence 27.57 10.59 71 284399 38110 70605864
Parosmia 27.49 10.59 61 284409 4870 70639104
Acute coronary syndrome 27.48 10.59 24 284446 20055 70623919
Hyperosmolar state 27.44 10.59 22 284448 631 70643343
Labelled drug-drug interaction issue 27.40 10.59 27 284443 1022 70642952
Burning sensation 27.31 10.59 114 284356 52756 70591218
Generalised oedema 27.31 10.59 28 284442 21680 70622294
Blood calcium decreased 27.28 10.59 46 284424 28800 70615174
Movement disorder 27.26 10.59 178 284292 23951 70620023
Lymphoma 27.18 10.59 14 284456 15448 70628526
Cytopenia 27.17 10.59 18 284452 17305 70626669
Microphthalmos 27.14 10.59 6 284464 0 70643974
Stoma site infection 27.11 10.59 30 284440 1302 70642672
Panniculitis 27.08 10.59 5 284465 10671 70633303
Disseminated intravascular coagulation 27.03 10.59 59 284411 33539 70610435
Therapeutic product effect incomplete 27.02 10.59 329 284141 119553 70524421
Oesophageal carcinoma 26.98 10.59 3 284467 9363 70634611
Personality disorder 26.93 10.59 65 284405 5483 70638491
Post procedural haemorrhage 26.89 10.59 9 284461 12857 70631117
Posterior reversible encephalopathy syndrome 26.89 10.59 35 284435 24367 70619607
Tuberculosis 26.77 10.59 13 284457 14835 70629139
Tooth disorder 26.72 10.59 34 284436 23904 70620070
Pemphigus 26.68 10.59 209 284261 82827 70561147
Clostridium difficile infection 26.65 10.59 74 284396 38742 70605232
Blood urine present 26.65 10.59 23 284447 19330 70624644
Morbid thoughts 26.64 10.59 23 284447 733 70643241
Limb discomfort 26.61 10.59 49 284421 29656 70614318
Heart rate decreased 26.59 10.59 143 284327 61872 70582102
Delusional perception 26.58 10.59 17 284453 338 70643636
Conduction disorder 26.42 10.59 46 284424 3072 70640902
Breast cancer female 26.41 10.59 5 284465 10481 70633493
Carpal tunnel syndrome 26.38 10.59 18 284452 17039 70626935
Sleep disorder due to a general medical condition 26.38 10.59 5 284465 10471 70633503
Compulsions 26.37 10.59 17 284453 343 70643631
Water intoxication 26.30 10.59 23 284447 746 70643228
Obsessive-compulsive personality disorder 26.16 10.59 12 284458 118 70643856
Cholangitis 26.09 10.59 7 284463 11542 70632432
Post procedural complication 26.09 10.59 30 284440 22051 70621923
Oral discharge 26.04 10.59 15 284455 245 70643729
Ill-defined disorder 25.88 10.59 122 284348 54619 70589355
Bone density decreased 25.84 10.59 7 284463 11467 70632507
Skin reaction 25.79 10.59 12 284458 14037 70629937
Intervertebral disc protrusion 25.64 10.59 29 284441 21474 70622500
Foot deformity 25.58 10.59 27 284443 20628 70623346
Dysphagia 25.32 10.59 612 283858 112222 70531752
Pancreatic carcinoma 25.32 10.59 10 284460 12894 70631080
Polyarthritis 25.31 10.59 6 284464 10750 70633224
Swelling face 25.27 10.59 149 284321 63015 70580959
Neutrophil count decreased 25.16 10.59 214 284256 83342 70560632
Folliculitis 25.09 10.59 87 284383 42483 70601491
Candida infection 24.97 10.59 64 284406 34409 70609565
Prostatic specific antigen increased 24.97 10.59 4 284466 9462 70634512
Hyporesponsive to stimuli 24.96 10.59 34 284436 1831 70642143
Skin infection 24.92 10.59 17 284453 16095 70627879
Facet joint syndrome 24.88 10.59 67 284403 6046 70637928
Organising pneumonia 24.87 10.59 5 284465 10045 70633929
Waxy flexibility 24.86 10.59 15 284455 268 70643706
Dry mouth 24.84 10.59 409 284061 70048 70573926
Hypoalbuminaemia 24.82 10.59 24 284446 19098 70624876
Erectile dysfunction 24.76 10.59 114 284356 13448 70630526
Megacolon 24.74 10.59 45 284425 3111 70640863
Atrial flutter 24.69 10.59 27 284443 20300 70623674
Penile haemorrhage 24.68 10.59 19 284451 513 70643461
Diverticulum 24.67 10.59 12 284458 13681 70630293
Cervix neoplasm 24.64 10.59 13 284457 177 70643797
Tooth infection 24.64 10.59 18 284452 16445 70627529
Eosinopenia 24.60 10.59 9 284461 46 70643928
Cholecystitis 24.60 10.59 28 284442 20673 70623301
Acute respiratory failure 24.56 10.59 121 284349 53544 70590430
Nystagmus 24.54 10.59 88 284382 9267 70634707
Hypervigilance 24.54 10.59 18 284452 451 70643523
Psychotic disorder due to a general medical condition 24.52 10.59 15 284455 275 70643699
Adverse drug reaction 24.43 10.59 324 284146 53020 70590954
Postmortem blood drug level 24.33 10.59 15 284455 279 70643695
Hypophosphataemia 24.24 10.59 18 284452 16308 70627666
Personality change due to a general medical condition 24.22 10.59 12 284458 142 70643832
Second primary malignancy 24.19 10.59 11 284459 13040 70630934
Somatic symptom disorder 24.19 10.59 35 284435 1995 70641979
Skin necrosis 24.14 10.59 18 284452 16273 70627701
Facial spasm 24.09 10.59 21 284449 678 70643296
Feeling jittery 24.09 10.59 101 284369 11442 70632532
Brachial plexopathy 24.07 10.59 12 284458 144 70643830
Illness anxiety disorder 24.02 10.59 14 284456 234 70643740
Choreoathetosis 23.97 10.59 30 284440 1486 70642488
Ageusia 23.91 10.59 15 284455 14847 70629127
Oesophageal candidiasis 23.83 10.59 3 284467 8504 70635470
Hepatic cancer 23.59 10.59 5 284465 9678 70634296
Dyslipidaemia 23.56 10.59 90 284380 9770 70634204
Bone erosion 23.48 10.59 16 284454 15157 70628817
Vasoplegia syndrome 23.48 10.59 44 284426 3112 70640862
Bacterial parotitis 23.44 10.59 8 284462 32 70643942
Cushingoid 23.39 10.59 3 284467 8385 70635589
Aphasia 23.39 10.59 271 284199 42978 70600996
Brain hypoxia 23.31 10.59 23 284447 872 70643102
Eye pruritus 23.27 10.59 15 284455 14632 70629342
Intestinal pseudo-obstruction 23.26 10.59 37 284433 2293 70641681
Patient uncooperative 23.25 10.59 20 284450 634 70643340
Overweight 23.25 10.59 47 284423 3516 70640458
Grandiosity 23.23 10.59 19 284451 561 70643413
C-reactive protein increased 23.16 10.59 308 284162 110209 70533765
Blood urea increased 23.09 10.59 100 284370 45809 70598165
Pneumonia viral 23.04 10.59 3 284467 8289 70635685
Muscle disorder 23.03 10.59 59 284411 5166 70638808
Haemorrhage intracranial 22.98 10.59 40 284430 24737 70619237
Product storage error 22.95 10.59 15 284455 14526 70629448
Procedural pain 22.91 10.59 23 284447 17986 70625988
Haematoma 22.84 10.59 108 284362 48310 70595664
Laboratory test abnormal 22.78 10.59 43 284427 25780 70618194
Gastrointestinal necrosis 22.78 10.59 58 284412 5060 70638914
Flashback 22.73 10.59 14 284456 260 70643714
COVID-19 pneumonia 22.71 10.59 33 284437 21936 70622038
Trichoglossia 22.70 10.59 18 284452 508 70643466
Gaze palsy 22.69 10.59 40 284430 2698 70641276
Eosinophil count decreased 22.64 10.59 41 284429 2825 70641149
Influenza like illness 22.63 10.59 161 284309 65170 70578804
Staphylococcal parotitis 22.61 10.59 5 284465 0 70643974
Seasonal allergy 22.55 10.59 13 284457 13471 70630503
Labelled drug-food interaction issue 22.51 10.59 8 284462 37 70643937
Metabolic encephalopathy 22.22 10.59 79 284391 8284 70635690
Blood pressure fluctuation 22.15 10.59 142 284328 58870 70585104
Chorea 22.14 10.59 34 284436 2044 70641930
Decreased bronchial secretion 22.12 10.59 9 284461 64 70643910
Obsessive thoughts 22.11 10.59 24 284446 1019 70642955
Jaundice cholestatic 22.09 10.59 84 284386 9100 70634874
Injection site haemorrhage 22.08 10.59 43 284427 25484 70618490
Postmortem blood drug level increased 22.05 10.59 21 284449 762 70643212
Metastases to lymph nodes 22.04 10.59 5 284465 9233 70634741
Enthesopathy 22.03 10.59 8 284462 10861 70633113
Myoclonic epilepsy 22.01 10.59 32 284438 1832 70642142
Respiratory tract congestion 21.94 10.59 23 284447 17630 70626344
Therapeutic product ineffective 21.86 10.59 30 284440 1627 70642347
Cardiac tamponade 21.86 10.59 4 284466 8591 70635383
Creatinine renal clearance decreased 21.85 10.59 22 284448 17178 70626796
Therapy cessation 21.81 10.59 66 284404 33610 70610364
Unevaluable event 21.80 10.59 121 284349 51942 70592032
Urine alcohol test positive 21.80 10.59 7 284463 22 70643952
Cardiac failure chronic 21.78 10.59 7 284463 10262 70633712
Graft versus host disease 21.75 10.59 17 284453 15006 70628968
Intentional medical device removal by patient 21.75 10.59 15 284455 340 70643634
Drug use disorder 21.66 10.59 77 284393 8074 70635900
Neonatal infection 21.57 10.59 7 284463 23 70643951
Retrograde ejaculation 21.56 10.59 13 284457 232 70643742
Sexual abuse 21.46 10.59 13 284457 234 70643740
Hostility 21.41 10.59 35 284435 2220 70641754
Metabolic acidosis 21.40 10.59 418 284052 73928 70570046
Infective pulmonary exacerbation of cystic fibrosis 21.39 10.59 11 284459 12147 70631827
Breast cancer metastatic 21.37 10.59 7 284463 10139 70633835
Enterocolitis 21.28 10.59 13 284457 13053 70630921
Communication disorder 21.22 10.59 47 284423 3747 70640227
Pruritus genital 21.21 10.59 24 284446 1068 70642906
Renal papillary necrosis 21.18 10.59 15 284455 355 70643619
Lip swelling 21.16 10.59 68 284402 33986 70609988
Gastrointestinal sounds abnormal 21.13 10.59 56 284414 5005 70638969
Eosinophilic pleural effusion 21.10 10.59 14 284456 297 70643677
Eye haemorrhage 21.04 10.59 5 284465 8944 70635030
Coordination abnormal 20.96 10.59 123 284347 15943 70628031
Formication 20.96 10.59 53 284417 4604 70639370
Renal tubular necrosis 20.95 10.59 38 284432 23133 70620841
Red blood cell count decreased 20.89 10.59 123 284347 52038 70591936
Cholecystitis acute 20.88 10.59 11 284459 11983 70631991
Cerebral infarction 20.84 10.59 95 284375 42914 70601060
Breast engorgement 20.81 10.59 8 284462 48 70643926
Electroencephalogram abnormal 20.77 10.59 57 284413 5201 70638773
Abnormal dreams 20.76 10.59 91 284379 10512 70633462
Oral candidiasis 20.76 10.59 43 284427 24909 70619065
Skin disorder 20.75 10.59 58 284412 30299 70613675
Abdominal pain lower 20.74 10.59 52 284418 28164 70615810
Orthopnoea 20.70 10.59 6 284464 9402 70634572
Spinal stenosis 20.69 10.59 17 284453 14636 70629338
C-reactive protein abnormal 20.67 10.59 82 284388 38497 70605477
Appendicitis 20.58 10.59 22 284448 16711 70627263
Device kink 20.53 10.59 30 284440 1725 70642249
Femur fracture 20.52 10.59 75 284395 36057 70607917
Wrong patient 20.50 10.59 14 284456 312 70643662
Faecal vomiting 20.42 10.59 23 284447 1018 70642956
Pulmonary oedema 20.41 10.59 221 284249 82057 70561917
Breast discharge 20.37 10.59 18 284452 592 70643382
Pneumonia bacterial 20.33 10.59 22 284448 16619 70627355
Macular degeneration 20.27 10.59 3 284467 7525 70636449
Musculoskeletal discomfort 20.25 10.59 25 284445 17807 70626167
Panic disorder 20.16 10.59 39 284431 2825 70641149
Toxic encephalopathy 20.14 10.59 89 284381 10317 70633657
Anti-cyclic citrullinated peptide antibody positive 20.14 10.59 182 284288 70003 70573971
Radial nerve palsy 20.10 10.59 16 284454 454 70643520
Hernia 20.05 10.59 18 284452 14842 70629132
Spasmodic dysphonia 20.00 10.59 12 284458 212 70643762
Eczema 19.93 10.59 69 284401 33712 70610262
Gastrointestinal hypomotility 19.92 10.59 30 284440 1773 70642201
Drug withdrawal syndrome neonatal 19.88 10.59 13 284457 269 70643705
Oral herpes 19.85 10.59 42 284428 24144 70619830
Blood osmolarity decreased 19.85 10.59 25 284445 1246 70642728
Aspartate aminotransferase increased 19.84 10.59 374 284096 126604 70517370
Abdominal distension 19.70 10.59 298 284172 104371 70539603
Musculoskeletal disorder 19.67 10.59 31 284439 19940 70624034
Therapeutic product effect variable 19.67 10.59 29 284441 1681 70642293
Glossodynia 19.62 10.59 237 284233 86250 70557724
Drug level above therapeutic 19.61 10.59 72 284398 7670 70636304
Dopamine dysregulation syndrome 19.52 10.59 16 284454 474 70643500
Haemolysis 19.51 10.59 11 284459 11540 70632434
Joint effusion 19.43 10.59 20 284450 15457 70628517
Encephalitis toxic 19.42 10.59 13 284457 280 70643694
Osteopenia 19.39 10.59 23 284447 16674 70627300
Hepatic encephalopathy 19.36 10.59 37 284433 22081 70621893
Muscle injury 19.27 10.59 84 284386 38410 70605564
Food craving 19.26 10.59 27 284443 1494 70642480
Gastric cancer 19.18 10.59 6 284464 8949 70635025
Sense of a foreshortened future 19.17 10.59 5 284465 5 70643969
Rebound psychosis 19.13 10.59 11 284459 179 70643795
Alcohol use 19.12 10.59 51 284419 4576 70639398
Somatic symptom disorder of pregnancy 19.06 10.59 9 284461 95 70643879
Urine output decreased 19.05 10.59 24 284446 16946 70627028
Helplessness 19.01 10.59 14 284456 353 70643621
Abnormal loss of weight 19.00 10.59 4 284466 7780 70636194
Sneezing 19.00 10.59 24 284446 16927 70627047
Job dissatisfaction 18.97 10.59 8 284462 63 70643911
Stoma site pain 18.90 10.59 24 284446 1206 70642768
IVth nerve disorder 18.89 10.59 6 284464 18 70643956
Fear of weight gain 18.89 10.59 6 284464 18 70643956
Generalised anxiety disorder 18.87 10.59 31 284439 1974 70642000
Postoperative wound infection 18.86 10.59 11 284459 11327 70632647
Conjunctivitis 18.84 10.59 39 284431 22597 70621377
Hospitalisation 18.83 10.59 226 284244 82342 70561632
Paralysis 18.82 10.59 97 284373 11975 70631999
Device difficult to use 18.81 10.59 10 284460 10839 70633135
Post procedural infection 18.76 10.59 9 284461 10344 70633630
Ketoacidosis 18.75 10.59 68 284402 7201 70636773
Lung adenocarcinoma 18.67 10.59 4 284466 7686 70636288
Neurodegenerative disorder 18.66 10.59 15 284455 432 70643542
Depressive delusion 18.65 10.59 6 284464 19 70643955
Tonic clonic movements 18.62 10.59 31 284439 1996 70641978
Parkinson's disease 18.61 10.59 29 284441 1766 70642208
Gynaecomastia 18.60 10.59 65 284405 6758 70637216
Atelectasis 18.59 10.59 57 284413 28905 70615069
Abscess 18.56 10.59 34 284436 20620 70623354
Agranulocytosis 18.55 10.59 245 284225 40053 70603921
Herpes simplex 18.54 10.59 11 284459 11221 70632753
Hepatic failure 18.53 10.59 145 284325 57480 70586494
Device malfunction 18.45 10.59 30 284440 19054 70624920
Aplastic anaemia 18.39 10.59 24 284446 16692 70627282
Apnoea 18.37 10.59 89 284381 10720 70633254
Sedation complication 18.37 10.59 104 284366 13306 70630668
Bladder prolapse 18.34 10.59 24 284446 1243 70642731
Hepatocellular carcinoma 18.31 10.59 9 284461 10199 70633775
Respiratory distress 18.29 10.59 136 284334 54514 70589460
Compulsive shopping 18.24 10.59 19 284451 769 70643205
Stoma site extravasation 18.24 10.59 13 284457 311 70643663
Verbal abuse 18.19 10.59 12 284458 252 70643722
Infusion site pain 18.16 10.59 12 284458 11552 70632422
Buccoglossal syndrome 18.09 10.59 4 284466 0 70643974
Hyperglycaemia 18.07 10.59 362 284108 64310 70579664
Hyponatraemic coma 18.07 10.59 7 284463 43 70643931
Rash macular 18.06 10.59 48 284422 25496 70618478
Phaeochromocytoma malignant 18.05 10.59 8 284462 72 70643902
Respiratory disorder 18.02 10.59 88 284382 39035 70604939
Multiple sclerosis relapse 18.00 10.59 100 284370 42917 70601057
Confabulation 18.00 10.59 15 284455 455 70643519
Psychogenic tremor 17.98 10.59 6 284464 22 70643952
Initial insomnia 17.98 10.59 61 284409 6248 70637726
Blood iron decreased 17.97 10.59 16 284454 13245 70630729
Swollen joint count increased 17.95 10.59 105 284365 13595 70630379
Skin mass 17.86 10.59 4 284466 7452 70636522
Antidepressant drug level increased 17.84 10.59 14 284456 389 70643585
Epstein-Barr virus infection 17.79 10.59 16 284454 13182 70630792
Prescription drug used without a prescription 17.76 10.59 38 284432 2959 70641015
Heparin-induced thrombocytopenia 17.74 10.59 7 284463 9030 70634944
Respiratory acidosis 17.73 10.59 85 284385 10196 70633778
Rotator cuff syndrome 17.70 10.59 15 284455 12719 70631255
Fall 17.67 10.59 2037 282433 442059 70201915
Multiple fractures 17.53 10.59 3 284467 6762 70637212
Kidney infection 17.51 10.59 32 284438 19423 70624551
Lack of spontaneous speech 17.50 10.59 11 284459 212 70643762
Painful erection 17.48 10.59 10 284460 161 70643813
Pyelonephritis 17.44 10.59 29 284441 18260 70625714
Withdrawal catatonia 17.32 10.59 10 284460 164 70643810
Feeling hot 17.32 10.59 119 284351 48551 70595423
Hyperthermia malignant 17.24 10.59 35 284435 2626 70641348
Drug dispensed to wrong patient 17.23 10.59 16 284454 562 70643412
Congenital cerebrovascular anomaly 17.16 10.59 5 284465 10 70643964
Conjunctival abrasion 17.16 10.59 5 284465 10 70643964
Migraine 17.14 10.59 196 284274 72042 70571932
Frequent bowel movements 17.14 10.59 37 284433 21116 70622858
Cerebral haemorrhage 17.11 10.59 136 284334 53728 70590246
Ankylosing spondylitis 17.08 10.59 13 284457 11633 70632341
Food refusal 17.06 10.59 15 284455 490 70643484
Electrocardiogram ST segment elevation 17.03 10.59 68 284402 7536 70636438
Ileus paralytic 17.01 10.59 75 284395 8686 70635288
Aortic stenosis 17.00 10.59 3 284467 6613 70637361
Tendon rupture 16.99 10.59 12 284458 11157 70632817
Thrombotic thrombocytopenic purpura 16.97 10.59 59 284411 6118 70637856
Drug resistance 16.97 10.59 87 284383 38103 70605871
Epidermolysis bullosa 16.89 10.59 11 284459 226 70643748
End stage renal disease 16.89 10.59 12 284458 11121 70632853
Head titubation 16.87 10.59 19 284451 841 70643133
Complication associated with device 16.84 10.59 23 284447 15690 70628284
Peripheral venous disease 16.75 10.59 86 284384 10601 70633373
Starvation ketoacidosis 16.71 10.59 9 284461 128 70643846
Frontotemporal dementia 16.67 10.59 16 284454 586 70643388
Choking 16.65 10.59 88 284382 10972 70633002
Autism spectrum disorder 16.64 10.59 21 284449 1049 70642925
Haematocrit decreased 16.64 10.59 148 284322 57110 70586864
Peritonitis bacterial 16.62 10.59 8 284462 9176 70634798
Bacterial sepsis 16.60 10.59 5 284465 7642 70636332
Brain natriuretic peptide increased 16.59 10.59 6 284464 8165 70635809
Ejaculation disorder 16.58 10.59 15 284455 509 70643465
Dermatitis 16.55 10.59 33 284437 19384 70624590
Cataract 16.54 10.59 143 284327 55502 70588472
Mobility decreased 16.52 10.59 302 284168 102697 70541277
Cardiac failure acute 16.43 10.59 28 284442 17459 70626515
Somatic delusion 16.42 10.59 17 284453 683 70643291
Electrocardiogram change 16.35 10.59 22 284448 1171 70642803
Product quality issue 16.35 10.59 65 284405 30496 70613478
Anamnestic reaction 16.35 10.59 6 284464 31 70643943
Blood sodium increased 16.35 10.59 47 284423 4405 70639569
Muscle spasticity 16.32 10.59 34 284436 19655 70624319
Orthostatic hypotension 16.30 10.59 295 284175 51448 70592526
Blood alkaline phosphatase increased 16.25 10.59 153 284317 58368 70585606
Gastrointestinal toxicity 16.25 10.59 3 284467 6402 70637572
Alanine aminotransferase abnormal 16.22 10.59 6 284464 8053 70635921
Hypernatraemia 16.20 10.59 97 284373 12664 70631310
Guillain-Barre syndrome 16.16 10.59 6 284464 8034 70635940
Peripheral arterial occlusive disease 16.14 10.59 5 284465 7504 70636470
Nail disorder 16.12 10.59 11 284459 10413 70633561
Poor quality sleep 16.11 10.59 138 284332 20211 70623763
Polyneuropathy 16.10 10.59 39 284431 21376 70622598
Neurological symptom 16.07 10.59 66 284404 7407 70636567
Lymphopenia 16.06 10.59 56 284414 27303 70616671
Vasculitis 16.02 10.59 34 284436 19524 70624450
Gait deviation 15.99 10.59 7 284463 61 70643913
Bronchospasm 15.99 10.59 43 284427 22749 70621225
Pulmonary alveolar haemorrhage 15.96 10.59 11 284459 10358 70633616
Delusion of reference 15.95 10.59 9 284461 141 70643833
Ventricular arrhythmia 15.94 10.59 68 284402 7762 70636212
Joint injury 15.90 10.59 55 284415 26877 70617097
Bladder dilatation 15.88 10.59 28 284442 1889 70642085
Labelled drug-food interaction medication error 15.84 10.59 9 284461 143 70643831
Electroconvulsive therapy 15.83 10.59 8 284462 99 70643875
Arthritis infective 15.82 10.59 5 284465 7407 70636567
Duodenal ulcer 15.75 10.59 23 284447 15257 70628717
Camptocormia 15.68 10.59 14 284456 467 70643507
Constipation 15.65 10.59 840 283630 251598 70392376
Aortic arteriosclerosis 15.60 10.59 6 284464 7863 70636111
Poriomania 15.59 10.59 10 284460 200 70643774
Obsessive-compulsive symptom 15.59 10.59 10 284460 200 70643774
Gait disturbance 15.51 10.59 899 283571 184207 70459767
Idiopathic intracranial hypertension 15.51 10.59 35 284435 2826 70641148
Spinal compression fracture 15.46 10.59 24 284446 15529 70628445
Glomerular filtration rate decreased 15.45 10.59 38 284432 20718 70623256
Wheezing 15.45 10.59 275 284195 93895 70550079
Spinal disorder 15.26 10.59 9 284461 9211 70634763
Breast enlargement 15.25 10.59 23 284447 1361 70642613
Synovial cyst 15.24 10.59 8 284462 8734 70635240
Nonspecific reaction 15.23 10.59 29 284441 2076 70641898
Epigastric discomfort 15.22 10.59 5 284465 7228 70636746
Renal tubular disorder 15.21 10.59 3 284467 6107 70637867
Arterial occlusive disease 15.19 10.59 6 284464 7736 70636238
Aphthous ulcer 15.16 10.59 22 284448 14634 70629340
Fear of injection 15.16 10.59 4 284466 6668 70637306
Lacrimation increased 15.15 10.59 36 284434 19863 70624111
Hyperuricaemia 15.14 10.59 13 284457 10953 70633021
Antisocial behaviour 15.09 10.59 15 284455 574 70643400
Distal intestinal obstruction syndrome 15.08 10.59 16 284454 662 70643312
Peritonitis 15.06 10.59 54 284416 26105 70617869
Nephrogenic systemic fibrosis 15.00 10.59 3 284467 6049 70637925
Tooth abscess 14.99 10.59 22 284448 14567 70629407
Poor venous access 14.98 10.59 23 284447 14948 70629026
Enterococcal infection 14.98 10.59 22 284448 14560 70629414
Respiratory syncytial virus infection 14.91 10.59 6 284464 7649 70636325
Brachial plexus injury 14.91 10.59 8 284462 113 70643861
Selective mutism 14.90 10.59 7 284463 73 70643901
Asocial behaviour 14.90 10.59 7 284463 73 70643901
Rib fracture 14.82 10.59 52 284418 25304 70618670
Hepatitis B 14.79 10.59 7 284463 8107 70635867
Endocarditis 14.74 10.59 11 284459 9943 70634031
Musculoskeletal chest pain 14.71 10.59 45 284425 22836 70621138
Deafness 14.64 10.59 35 284435 19268 70624706
Graft versus host disease in gastrointestinal tract 14.62 10.59 3 284467 5941 70638033
Groin pain 14.62 10.59 16 284454 12026 70631948
Chromaturia 14.61 10.59 47 284423 23481 70620493
Transient ischaemic attack 14.59 10.59 116 284354 45828 70598146
Live birth 14.57 10.59 100 284370 13679 70630295
False positive investigation result 14.56 10.59 18 284452 880 70643094
Gestational hypertension 14.54 10.59 26 284444 1774 70642200
Liver function test increased 14.54 10.59 78 284392 33769 70610205
Medical device site injury 14.45 10.59 4 284466 6 70643968
Crush injury 14.45 10.59 4 284466 6 70643968
Violence-related symptom 14.43 10.59 16 284454 696 70643278
Libido decreased 14.43 10.59 48 284422 4868 70639106
Lower gastrointestinal haemorrhage 14.36 10.59 23 284447 14697 70629277
Polymerase chain reaction 14.31 10.59 8 284462 123 70643851
Neuroleptic-induced deficit syndrome 14.27 10.59 5 284465 22 70643952
Bone marrow eosinophilic leukocyte count increased 14.27 10.59 5 284465 22 70643952
Intervertebral disc degeneration 14.25 10.59 21 284449 13879 70630095
Mitral valve incompetence 14.20 10.59 57 284413 26671 70617303
Distractibility 14.19 10.59 16 284454 709 70643265
Wrong technique in product usage process 14.19 10.59 192 284278 68506 70575468
Pupillary light reflex tests abnormal 14.13 10.59 11 284459 302 70643672
Small intestinal obstruction 14.12 10.59 51 284419 24604 70619370
Chronic lymphocytic leukaemia 14.11 10.59 3 284467 5795 70638179
Dry eye 14.08 10.59 74 284396 32208 70611766
Dysmetropsia 14.04 10.59 7 284463 84 70643890
Hallucination, olfactory 13.97 10.59 13 284457 458 70643516
Multiple-drug resistance 13.94 10.59 6 284464 7349 70636625
Disturbance in sexual arousal 13.94 10.59 9 284461 182 70643792
Salivary gland calculus 13.93 10.59 10 284460 242 70643732
Lipids increased 13.92 10.59 23 284447 1472 70642502
Gastritis erosive 13.90 10.59 12 284458 10083 70633891
Electrocardiogram T wave inversion 13.78 10.59 48 284422 4983 70638991
Urine sodium increased 13.77 10.59 9 284461 186 70643788
Tourette's disorder 13.76 10.59 7 284463 88 70643886
Perinatal depression 13.74 10.59 11 284459 315 70643659
Intermittent explosive disorder 13.73 10.59 4 284466 8 70643966
Thermal burn 13.73 10.59 57 284413 6429 70637545
Cyanosis 13.73 10.59 148 284322 23058 70620916
Pericarditis 13.69 10.59 248 284222 84457 70559517
Induced abortion failed 13.69 10.59 9 284461 188 70643786
Hyperglycaemic hyperosmolar nonketotic syndrome 13.67 10.59 26 284444 1860 70642114
Hepatic cirrhosis 13.66 10.59 70 284400 30661 70613313
Thought blocking 13.64 10.59 9 284461 189 70643785
Rash erythematous 13.61 10.59 137 284333 51581 70592393
Drug abuser 13.58 10.59 53 284417 5811 70638163
Bronchial aspiration procedure 13.58 10.59 10 284460 252 70643722
Rheumatic fever 13.58 10.59 119 284351 17541 70626433
Neurological decompensation 13.57 10.59 46 284424 4710 70639264
Antidepressant drug level 13.57 10.59 3 284467 0 70643974
Lack of satiety 13.57 10.59 3 284467 0 70643974
Erotomanic delusion 13.57 10.59 3 284467 0 70643974
Defect conduction intraventricular 13.52 10.59 12 284458 397 70643577
Bulimia nervosa 13.51 10.59 10 284460 254 70643720
Contraindication to medical treatment 13.49 10.59 20 284450 1165 70642809
Muscle atrophy 13.47 10.59 13 284457 10357 70633617
Cerebral atrophy 13.45 10.59 63 284407 7484 70636490
Liver abscess 13.42 10.59 3 284467 5596 70638378
Polyp 13.36 10.59 6 284464 7164 70636810
Drug eruption 13.35 10.59 98 284372 39398 70604576
Patient isolation 13.35 10.59 6 284464 56 70643918
Amimia 13.35 10.59 6 284464 56 70643918
Flat affect 13.31 10.59 26 284444 1897 70642077
Diabetic complication 13.29 10.59 20 284450 1181 70642793
Peripheral vascular disorder 13.28 10.59 7 284463 7625 70636349
Metastasis 13.27 10.59 4 284466 6110 70637864
Ischaemic stroke 13.25 10.59 71 284399 30749 70613225
Indifference 13.25 10.59 10 284460 262 70643712
Product communication issue 13.24 10.59 16 284454 764 70643210
Pseudomonal sepsis 13.20 10.59 3 284467 5534 70638440
Learning disability 13.20 10.59 9 284461 200 70643774
Large intestine polyp 13.12 10.59 16 284454 11460 70632514
Sleep terror 13.11 10.59 20 284450 1195 70642779
Liver disorder 13.11 10.59 171 284299 61397 70582577
Cytomegalovirus test positive 13.10 10.59 3 284467 5505 70638469
Haemolytic anaemia 13.09 10.59 30 284440 16764 70627210
Heart rate irregular 13.08 10.59 68 284402 29675 70614299
Rebound effect 13.05 10.59 53 284417 5918 70638056
Retinal detachment 13.01 10.59 9 284461 8458 70635516
Alanine aminotransferase increased 13.00 10.59 472 283998 147008 70496966
Volvulus 12.95 10.59 29 284441 2329 70641645
Wrong product administered 12.95 10.59 67 284403 8284 70635690
Tongue paralysis 12.93 10.59 12 284458 421 70643553
Hydronephrosis 12.91 10.59 26 284444 15216 70628758
Allergic hepatitis 12.87 10.59 5 284465 31 70643943
Immune thrombocytopenia 12.86 10.59 29 284441 16295 70627679
Scoliosis 12.85 10.59 5 284465 6506 70637468
Anion gap increased 12.84 10.59 35 284435 3181 70640793
Sickle cell anaemia with crisis 12.81 10.59 4 284466 5974 70638000
Ocular hyperaemia 12.80 10.59 53 284417 24586 70619388
Immobilisation prolonged 12.79 10.59 7 284463 103 70643871
Portal hypertension 12.79 10.59 5 284465 6487 70637487
Eye swelling 12.77 10.59 50 284420 23564 70620410
Posturing 12.76 10.59 18 284452 1002 70642972
Postoperative respiratory failure 12.74 10.59 8 284462 154 70643820
Feminisation acquired 12.74 10.59 5 284465 32 70643942
Tachypnoea 12.72 10.59 173 284297 28465 70615509
Increased tendency to bruise 12.72 10.59 12 284458 9663 70634311
Cardiotoxicity 12.71 10.59 82 284388 10988 70632986
Central nervous system injury 12.69 10.59 8 284462 155 70643819
Dysuria 12.68 10.59 256 284214 45538 70598436
Mixed dementia 12.68 10.59 10 284460 280 70643694
Myocardial ischaemia 12.61 10.59 52 284418 24148 70619826
Blood potassium decreased 12.61 10.59 109 284361 42312 70601662
Breath sounds abnormal 12.60 10.59 21 284449 13210 70630764
Product prescribing error 12.59 10.59 223 284247 38729 70605245
Aortic aneurysm 12.59 10.59 8 284462 7865 70636109
Bacterial infection 12.55 10.59 59 284411 26433 70617541
Dysphemia 12.52 10.59 35 284435 3228 70640746
Pathological fracture 12.47 10.59 12 284458 9571 70634403
Escherichia bacteraemia 12.45 10.59 4 284466 5865 70638109
Hyperdynamic left ventricle 12.44 10.59 11 284459 362 70643612
Electrocardiogram ST segment depression 12.43 10.59 43 284427 4448 70639526
SARS-CoV-2 test positive 12.40 10.59 10 284460 8691 70635283
Autoimmune hepatitis 12.37 10.59 15 284455 10771 70633203
Vitamin K decreased 12.34 10.59 6 284464 68 70643906
Arthritis bacterial 12.32 10.59 9 284461 8224 70635750
Patella fracture 12.31 10.59 23 284447 1623 70642351
Stab wound 12.29 10.59 9 284461 225 70643749
Neuropsychiatric symptoms 12.28 10.59 18 284452 1038 70642936
Foot fracture 12.28 10.59 39 284431 19561 70624413
Rhinitis 12.28 10.59 17 284453 11530 70632444
Echolalia 12.27 10.59 11 284459 369 70643605
Multiple allergies 12.26 10.59 8 284462 7752 70636222
Catheterisation cardiac 12.26 10.59 3 284467 5260 70638714
Malignant polyp 12.21 10.59 8 284462 166 70643808
Tricuspid valve incompetence 12.21 10.59 34 284436 17783 70626191
Splenomegaly 12.21 10.59 37 284433 18833 70625141
Mass 12.20 10.59 29 284441 15997 70627977
Lip dry 12.18 10.59 74 284396 9711 70634263
Haematemesis 12.13 10.59 131 284339 48666 70595308
Delusional disorder, erotomanic type 12.12 10.59 5 284465 37 70643937
Stoma site odour 12.11 10.59 6 284464 71 70643903
Anhedonia 12.11 10.59 98 284372 14115 70629859
Retinal haemorrhage 12.11 10.59 8 284462 7702 70636272
Hypothyroidism 12.09 10.59 254 284216 45501 70598473
Drug specific antibody present 12.08 10.59 4 284466 5754 70638220
Dialysis 12.08 10.59 33 284437 17369 70626605
Protein urine present 12.07 10.59 12 284458 9428 70634546
Hyperbilirubinaemia 12.07 10.59 48 284422 22520 70621454
Diastolic dysfunction 12.06 10.59 12 284458 9421 70634553
Gingival pain 12.05 10.59 6 284464 6751 70637223
Gingival bleeding 12.05 10.59 27 284443 15205 70628769
Dermatitis atopic 12.05 10.59 11 284459 8996 70634978
Haemorrhagic stroke 12.01 10.59 14 284456 10228 70633746
Agitated depression 12.01 10.59 10 284460 303 70643671
Thrombosis in device 11.95 10.59 3 284467 5172 70638802
Product counterfeit 11.95 10.59 9 284461 235 70643739
Thyroid cancer 11.85 10.59 3 284467 5142 70638832
Gastrointestinal perforation 11.83 10.59 4 284466 5677 70638297
Delirium febrile 11.82 10.59 6 284464 75 70643899
Female sexual dysfunction 11.79 10.59 5 284465 40 70643934
Bradycardia 11.77 10.59 612 283858 124003 70519971
Dermatitis exfoliative 11.76 10.59 15 284455 10536 70633438
Intercepted medication error 11.76 10.59 16 284454 861 70643113
Meniscus injury 11.74 10.59 5 284465 6162 70637812
Stoma site induration 11.68 10.59 5 284465 41 70643933
Cardiac death 11.65 10.59 21 284449 1442 70642532
Parainfluenzae virus infection 11.63 10.59 3 284467 5077 70638897
Cholinergic syndrome 11.63 10.59 16 284454 870 70643104
Hysterectomy 11.60 10.59 4 284466 5608 70638366
Fistula 11.59 10.59 16 284454 10865 70633109
Encopresis 11.55 10.59 7 284463 126 70643848
Lactate pyruvate ratio increased 11.55 10.59 6 284464 79 70643895
Splenic injury 11.50 10.59 9 284461 249 70643725
Compulsive sexual behaviour 11.50 10.59 9 284461 249 70643725
Propulsive gait 11.50 10.59 3 284467 3 70643971
Proctalgia 11.50 10.59 10 284460 8373 70635601
Abdominal abscess 11.50 10.59 6 284464 6572 70637402
Cerebral amyloid angiopathy 11.49 10.59 10 284460 322 70643652
Regressive behaviour 11.46 10.59 7 284463 128 70643846
Glycosuria 11.44 10.59 26 284444 2109 70641865
Keratoconus 11.42 10.59 6 284464 81 70643893
Drug monitoring procedure incorrectly performed 11.39 10.59 11 284459 406 70643568
Pulmonary embolism 11.38 10.59 748 283722 155119 70488855
Anaphylactoid reaction 11.38 10.59 3 284467 5004 70638970
Shock haemorrhagic 11.36 10.59 36 284434 18070 70625904
Peripheral ischaemia 11.36 10.59 11 284459 8747 70635227
Soliloquy 11.35 10.59 13 284457 586 70643388
Ventricular fibrillation 11.33 10.59 162 284308 26949 70617025
Cataplexy 11.32 10.59 17 284453 1002 70642972
Necrotising fasciitis 11.32 10.59 4 284466 5522 70638452
Staphylococcal sepsis 11.29 10.59 23 284447 13404 70630570
Lipase increased 11.28 10.59 28 284442 15218 70628756
Crepitations 11.23 10.59 11 284459 8703 70635271
Cardiac disorder 11.23 10.59 169 284301 59246 70584728
Blood uric acid increased 11.23 10.59 12 284458 9117 70634857
Spinal pain 11.23 10.59 24 284446 13746 70630228
Aortic valve stenosis 11.22 10.59 3 284467 4956 70639018
Arteriosclerosis 11.21 10.59 32 284438 16606 70627368
Laryngeal dyspnoea 11.20 10.59 9 284461 259 70643715
Flail chest 11.16 10.59 6 284464 85 70643889
Renal cyst 11.10 10.59 23 284447 13322 70630652
Pharyngeal dystonia 11.09 10.59 5 284465 47 70643927
Penile discharge 11.09 10.59 5 284465 47 70643927
Staphylococcus test positive 11.06 10.59 5 284465 5949 70638025
Cardiopulmonary failure 11.05 10.59 53 284417 6357 70637617
Sleep talking 11.05 10.59 17 284453 1024 70642950
Electrolyte substitution therapy 11.04 10.59 3 284467 4 70643970
Drug withdrawal headache 11.04 10.59 6 284464 87 70643887
Corneal reflex decreased 11.01 10.59 10 284460 341 70643633
Bone lesion 11 10.59 4 284466 5426 70638548
Muscle contractions involuntary 11.00 10.59 34 284436 3317 70640657
Neurological examination abnormal 10.97 10.59 12 284458 514 70643460
Spinal fracture 10.97 10.59 31 284439 16136 70627838
Oesophageal food impaction 10.97 10.59 10 284460 343 70643631
Forced expiratory volume decreased 10.94 10.59 8 284462 7306 70636668
Carbon monoxide poisoning 10.94 10.59 9 284461 268 70643706
Non-cardiac chest pain 10.92 10.59 12 284458 9003 70634971
Coronary artery occlusion 10.88 10.59 26 284444 14319 70629655
Ammonia increased 10.88 10.59 57 284413 7081 70636893
Upper limb fracture 10.87 10.59 31 284439 16088 70627886
Lung perforation 10.86 10.59 6 284464 90 70643884
Non-small cell lung cancer 10.79 10.59 6 284464 6341 70637633
Portal vein thrombosis 10.78 10.59 4 284466 5358 70638616
Peripheral circulatory failure 10.78 10.59 17 284453 1046 70642928
Granuloma 10.77 10.59 9 284461 7686 70636288
Pulmonary function test decreased 10.76 10.59 7 284463 6794 70637180
Subarachnoid haemorrhage 10.74 10.59 41 284429 19463 70624511
Heart rate abnormal 10.74 10.59 48 284422 5591 70638383
Mouth swelling 10.74 10.59 4 284466 5345 70638629
Spinal osteoarthritis 10.73 10.59 29 284441 15319 70628655
Breast discomfort 10.73 10.59 10 284460 353 70643621
Breast cancer stage II 10.73 10.59 4 284466 5342 70638632
Rapid eye movement sleep behaviour disorder 10.68 10.59 10 284460 355 70643619
Eye infection 10.65 10.59 15 284455 10103 70633871
Helicobacter infection 10.63 10.59 158 284312 55498 70588476
Tooth extraction 10.63 10.59 15 284455 10092 70633882
Invasive ductal breast carcinoma 10.60 10.59 5 284465 5804 70638170

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Tricuspid valve incompetence 32.67 25.26 21 2171 52 87548
Meconium aspiration syndrome 32.44 25.26 19 2173 37 87563
Hypertonia neonatal 31.07 25.26 39 2153 288 87312
Withdrawal syndrome 26.87 25.26 22 2170 89 87511

Pharmacologic Action:

SourceCodeDescription
ATC N05AH04 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Diazepines, oxazepines, thiazepines and oxepines
FDA EPC N0000175430 Atypical Antipsychotic
MeSH PA D000928 Antidepressive Agents
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents
CHEBI has role CHEBI:37887 adrenergic blockers
CHEBI has role CHEBI:37956 antihistamines
CHEBI has role CHEBI:48279 serotonin antagonists
CHEBI has role CHEBI:48561 dopaminergic antagonists
CHEBI has role CHEBI:65191 atypical antipsychotic agent

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Bipolar disorder indication 13746004 DOID:3312
Schizophrenia indication 58214004 DOID:5419
Bipolar disorder in remission indication 85248005
Bipolar affective disorder, current episode manic indication 191618007
Bipolar affective disorder, current episode depression indication 191627008 DOID:3312
Depression Treatment Adjunct indication
Suicidal thoughts contraindication 6471006
Weight gain finding contraindication 8943002
Hypercholesterolemia contraindication 13644009
Asthenia contraindication 13791008
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Agranulocytosis contraindication 17182001 DOID:12987
Lowered convulsive threshold contraindication 19260006
Myocardial infarction contraindication 22298006 DOID:5844
Hypovolemia contraindication 28560003
Orthostatic hypotension contraindication 28651003
Torsades de pointes contraindication 31722008
Dehydration contraindication 34095006
Hypertensive disorder contraindication 38341003 DOID:10763
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Hyperlipidemia contraindication 55822004 DOID:1168
Cerebrovascular disease contraindication 62914000 DOID:6713
Diabetes mellitus contraindication 73211009 DOID:9351
Extrapyramidal disease contraindication 76349003
Hyperglycemia contraindication 80394007 DOID:4195
Leukopenia contraindication 84828003 DOID:615
Bilateral cataracts contraindication 95722004
Tardive dyskinesia contraindication 102449007
Prolonged QT interval contraindication 111975006
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Hypomagnesemia contraindication 190855004
Disease of liver contraindication 235856003 DOID:409
Metabolic syndrome X contraindication 237602007 DOID:14221
Hyperprolactinemia contraindication 237662005 DOID:12700
Anemia contraindication 271737000 DOID:2355
Hypertriglyceridemia contraindication 302870006
Neutropenic disorder contraindication 303011007 DOID:1227
At risk for aspiration contraindication 371736008
Impaired cognition contraindication 386806002
Myocardial ischemia contraindication 414795007 DOID:3393
Obesity contraindication 414916001 DOID:9970
Acquired torsion dystonia contraindication 433493000
Congenital long QT syndrome contraindication 442917000
Carcinoma of female breast contraindication 447782002
Smokes tobacco daily contraindication 449868002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.94 Basic
pKa2 3.9 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST IC50 7.13 WOMBAT-PK CHEMBL
D(2) dopamine receptor GPCR ANTAGONIST IC50 6.48 WOMBAT-PK CHEMBL
Beta-2 adrenergic receptor GPCR Ki 5.30 PDSP
D(1A) dopamine receptor GPCR Ki 6.41 CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 5.44 PDSP
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.02 DRUG MATRIX
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.24 CHEMBL
Sodium-dependent noradrenaline transporter Transporter INHIBITOR Ki 6.03 IUPHAR
5-hydroxytryptamine receptor 1A GPCR IC50 6.83 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR IC50 6.52 WOMBAT-PK
5-hydroxytryptamine receptor 2C GPCR ANTAGONIST IC50 7 WOMBAT-PK
5-hydroxytryptamine receptor 6 GPCR Ki 5.85 CHEMBL
5-hydroxytryptamine receptor 7 GPCR Ki 6.51 PDSP
Alpha-1A adrenergic receptor GPCR IC50 7.03 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 6.13 PDSP
D(3) dopamine receptor GPCR ANTAGONIST Ki 6.49 CHEMBL
D(1B) dopamine receptor GPCR Ki 5.79 PDSP
Histamine H1 receptor GPCR IC50 8.35 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR Ki 7.25 CHEMBL
Muscarinic acetylcholine receptor M2 GPCR Ki 6.04 PDSP
Muscarinic acetylcholine receptor M3 GPCR Ki 5.80 PDSP
Muscarinic acetylcholine receptor M4 GPCR Ki 6.27 PDSP
Muscarinic acetylcholine receptor M5 GPCR Ki 5.52 PDSP
Aldehyde oxidase Enzyme IC50 5.85 WOMBAT-PK
5-hydroxytryptamine receptor 1B GPCR Ki 5.82 PDSP
5-hydroxytryptamine receptor 1D GPCR AGONIST Ki 5.70 IUPHAR
Alpha-2C adrenergic receptor GPCR IC50 6.24 WOMBAT-PK
D(4) dopamine receptor GPCR ANTAGONIST Ki 5.80 CHEMBL
Alpha-1D adrenergic receptor GPCR Ki 7.46 DRUG MATRIX
Alpha-1B adrenergic receptor GPCR Ki 7.41 PDSP
5-hydroxytryptamine receptor 5A GPCR Ki 5.51 PDSP
5-hydroxytryptamine receptor 1F GPCR AGONIST Ki 5.60 IUPHAR
5-hydroxytryptamine receptor 1E GPCR AGONIST Ki 5.90 IUPHAR
Histone H1.0 Nuclear other Ki 8 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 5.30 PDSP
Alpha-1B adrenergic receptor GPCR Ki 7.87 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR IC50 7.06 CHEMBL
Histamine H1 receptor GPCR Ki 7.40 CHEMBL
D(2) dopamine receptor GPCR Ki 6.74 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 6.64 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 6.66 CHEMBL
Histamine H1 receptor GPCR IC50 7.40 CHEMBL
Transporter Transporter Ki 6.17 CHEMBL
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 5.94 DRUG MATRIX

External reference:

IDSource
4024080 VUID
N0000022085 NUI
D00458 KEGG_DRUG
111974-72-2 SECONDARY_CAS_RN
4021057 VANDF
4024080 VANDF
C0123091 UMLSCUI
CHEBI:8707 CHEBI
CHEMBL716 ChEMBL_ID
DB01224 DRUGBANK_ID
CHEMBL1200911 ChEMBL_ID
CHEMBL3188993 ChEMBL_ID
D000069348 MESH_DESCRIPTOR_UI
5002 PUBCHEM_CID
50 IUPHAR_LIGAND_ID
7467 INN_ID
BGL0JSY5SI UNII
221153 RXNORM
11319 MMSL
187788 MMSL
33804 MMSL
5399 MMSL
d04220 MMSL
006939 NDDF
006940 NDDF
108383008 SNOMEDCT_US
108443001 SNOMEDCT_US
386850001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0220 TABLET 25 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0220 TABLET 25 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0221 TABLET 100 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0221 TABLET 100 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0222 TABLET 200 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0222 TABLET 200 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0223 TABLET 300 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0223 TABLET 300 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0229 TABLET 50 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0229 TABLET 50 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0230 TABLET 400 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0230 TABLET 400 mg ORAL ANDA 34 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-2063 TABLET, FILM COATED 25 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-2063 TABLET, FILM COATED 25 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8162 TABLET, FILM COATED 100 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8162 TABLET, FILM COATED 100 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8163 TABLET, FILM COATED 200 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8163 TABLET, FILM COATED 200 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8164 TABLET, FILM COATED 300 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8164 TABLET, FILM COATED 300 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8165 TABLET, FILM COATED 400 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8165 TABLET, FILM COATED 400 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8166 TABLET, FILM COATED 50 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8166 TABLET, FILM COATED 50 mg ORAL ANDA 32 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0271 TABLET, FILM COATED 100 mg ORAL NDA 32 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0272 TABLET, FILM COATED 200 mg ORAL NDA 32 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0274 TABLET, FILM COATED 300 mg ORAL NDA 32 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0275 TABLET, FILM COATED 25 mg ORAL NDA 32 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0278 TABLET, FILM COATED 50 mg ORAL NDA 32 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0279 TABLET, FILM COATED 400 mg ORAL NDA 32 sections