pyrvinium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| quaternary ammonium compounds | 2335 | 3546-41-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.35 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 5 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA | PARKE DAVIS |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | P02CX01 | ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ANTHELMINTICS ANTINEMATODAL AGENTS Other antinematodals |
| MeSH PA | D000871 | Anthelmintics |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000977 | Antiparasitic Agents |
| CHEBI has role | CHEBI:149553 | anticoronaviral drug |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.97 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Androgen receptor | Nuclear hormone receptor | IC50 | 6.72 | CHEMBL | |||||
| Casein kinase I isoform alpha | Kinase | Kd | 9 | CHEMBL | |||||
| Synaptojanin-2 | Enzyme | IC50 | 5.90 | CHEMBL | |||||
| Synaptojanin-1 | Enzyme | IC50 | 6 | CHEMBL | |||||
| Serine hydroxymethyltransferase, mitochondrial | Enzyme | IC50 | 5.59 | CHEMBL | |||||
| Fumarate reductase | Unclassified | IC50 | 6.30 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D00489 | KEGG_DRUG |
| C0072804 | UMLSCUI |
| CHEBI:8688 | CHEBI |
| CHEMBL1201303 | ChEMBL_ID |
| CHEMBL1908377 | ChEMBL_ID |
| DB06816 | DRUGBANK_ID |
| C024631 | MESH_SUPPLEMENTAL_RECORD_UI |
| 6B9991FLU3 | UNII |
| 5281035 | PUBCHEM_CID |
| 35163 | RXNORM |
| 002984 | NDDF |
| 007377 | NDDF |
| 44330008 | SNOMEDCT_US |
| 707543009 | SNOMEDCT_US |
| D011774 | MESH_DESCRIPTOR_UI |
| 7187-62-4 | SECONDARY_CAS_RN |
Pharmaceutical products:
None