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| Stem definition | Drug id | CAS RN |
|---|---|---|
| acetylcholinesterase inhibitors | 2330 | 155-97-5 |
| Dose | Unit | Route |
|---|---|---|
| 0.18 | g | O |
| 10 | mg | P |
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 52 mg/mL | Bocci G, Oprea TI, Benet LZ |
| EoM (Fraction excreted unchanged in urine) | 85 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 76.59 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 7.60 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 1.10 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 9.60 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 1 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 1.50 hours | Lombardo F, Berellini G, Obach RS |
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK2,MAP3K21,MAP3K7,MAPK7,MAPKAPK2,NTRK2,PDK2,PDK4,PIK3CB,PRKDC,SIK2,SIK3,STK33,TEK | 32 | |||
| kinase-selectivity-class | AXL,BRAF,CDK9,DDR1,GRK2,MAP2K6,MAPK7,MARK4,SIK2,STK33,TEK,TTK | 12 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
| Date | Agency | Company | Orphan |
|---|---|---|---|
| April 6, 1955 | FDA | VALEANT PHARMS LLC |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Myasthenia gravis | 896.97 | 15.63 | 199 | 10664 | 6626 | 90610958 |
| Myasthenia gravis crisis | 547.07 | 15.63 | 97 | 10766 | 967 | 90616617 |
| Eyelid ptosis | 116.60 | 15.63 | 43 | 10820 | 8963 | 90608621 |
| Diplopia | 115.09 | 15.63 | 60 | 10803 | 28654 | 90588930 |
| Off label use | 114.56 | 15.63 | 339 | 10524 | 1101913 | 89515671 |
| Thymoma | 95.30 | 15.63 | 18 | 10845 | 260 | 90617324 |
| Dysphagia | 54.13 | 15.63 | 67 | 10796 | 112211 | 90505373 |
| Postural orthostatic tachycardia syndrome | 45.41 | 15.63 | 15 | 10848 | 2257 | 90615327 |
| Myasthenic syndrome | 43.66 | 15.63 | 10 | 10853 | 382 | 90617202 |
| COVID-19 | 43.62 | 15.63 | 75 | 10788 | 168768 | 90448816 |
| Speech disorder | 43.17 | 15.63 | 39 | 10824 | 45546 | 90572038 |
| Bradycardia | 41.96 | 15.63 | 51 | 10812 | 83796 | 90533788 |
| Adiposis dolorosa | 40.33 | 15.63 | 9 | 10854 | 305 | 90617279 |
| Meningitis aseptic | 38.60 | 15.63 | 18 | 10845 | 6755 | 90610829 |
| Muscular weakness | 37.53 | 15.63 | 79 | 10784 | 206587 | 90410997 |
| Drug ineffective | 36.32 | 15.63 | 286 | 10577 | 1384012 | 89233572 |
| Nocardiosis | 35.97 | 15.63 | 13 | 10850 | 2557 | 90615027 |
| Cerebral toxoplasmosis | 35.15 | 15.63 | 11 | 10852 | 1394 | 90616190 |
| Oromandibular dystonia | 34.50 | 15.63 | 9 | 10854 | 594 | 90616990 |
| Diaphragmatic paralysis | 33.22 | 15.63 | 9 | 10854 | 687 | 90616897 |
| Blood pressure increased | 33.06 | 15.63 | 73 | 10790 | 197144 | 90420440 |
| Glucose tolerance impaired | 32.88 | 15.63 | 17 | 10846 | 7968 | 90609616 |
| Drug ineffective for unapproved indication | 32.47 | 15.63 | 40 | 10823 | 66604 | 90550980 |
| Therapy non-responder | 30.52 | 15.63 | 57 | 10806 | 136647 | 90480937 |
| Symptom recurrence | 30.52 | 15.63 | 13 | 10850 | 3946 | 90613638 |
| Antiacetylcholine receptor antibody positive | 28.76 | 15.63 | 6 | 10857 | 147 | 90617437 |
| Cholinergic syndrome | 28.59 | 15.63 | 8 | 10855 | 688 | 90616896 |
| Arthropathy | 28.11 | 15.63 | 5 | 10858 | 366237 | 90251347 |
| Glossodynia | 27.97 | 15.63 | 3 | 10860 | 321776 | 90295808 |
| Brain abscess | 27.68 | 15.63 | 11 | 10852 | 2801 | 90614783 |
| Bulbar palsy | 27.65 | 15.63 | 5 | 10858 | 56 | 90617528 |
| Systemic lupus erythematosus | 27.64 | 15.63 | 5 | 10858 | 361891 | 90255693 |
| Ocular myasthenia | 27.53 | 15.63 | 6 | 10857 | 182 | 90617402 |
| Borderline leprosy | 26.83 | 15.63 | 4 | 10859 | 11 | 90617573 |
| Product residue present | 26.32 | 15.63 | 12 | 10851 | 4279 | 90613305 |
| Respiratory distress | 25.08 | 15.63 | 27 | 10836 | 38919 | 90578665 |
| Rebound effect | 24.99 | 15.63 | 15 | 10848 | 9369 | 90608215 |
| Asthenia | 24.94 | 15.63 | 128 | 10735 | 533623 | 90083961 |
| Respiratory failure | 24.73 | 15.63 | 48 | 10815 | 118370 | 90499214 |
| Product substitution issue | 24.50 | 15.63 | 19 | 10844 | 17989 | 90599595 |
| Arteriospasm coronary | 24.45 | 15.63 | 12 | 10851 | 5038 | 90612546 |
| Thymectomy | 24.09 | 15.63 | 3 | 10860 | 0 | 90617584 |
| Acute on chronic liver failure | 23.99 | 15.63 | 6 | 10857 | 334 | 90617250 |
| Dysarthria | 23.84 | 15.63 | 31 | 10832 | 54451 | 90563133 |
| Wound | 23.54 | 15.63 | 4 | 10859 | 302976 | 90314608 |
| Menopause | 22.64 | 15.63 | 10 | 10853 | 3311 | 90614273 |
| Wrong patient received product | 22.20 | 15.63 | 10 | 10853 | 3467 | 90614117 |
| Sinoatrial block | 21.56 | 15.63 | 7 | 10856 | 998 | 90616586 |
| Suspected COVID-19 | 21.30 | 15.63 | 9 | 10854 | 2677 | 90614907 |
| Hepatitis B surface antibody positive | 20.88 | 15.63 | 5 | 10858 | 232 | 90617352 |
| Supine hypertension | 20.79 | 15.63 | 4 | 10859 | 64 | 90617520 |
| Solar lentigo | 20.46 | 15.63 | 7 | 10856 | 1173 | 90616411 |
| Sensory disturbance | 20.40 | 15.63 | 16 | 10847 | 15397 | 90602187 |
| Salivary hypersecretion | 20.32 | 15.63 | 13 | 10850 | 9079 | 90608505 |
| Apnoea | 19.91 | 15.63 | 13 | 10850 | 9401 | 90608183 |
| Myocardial necrosis marker increased | 19.64 | 15.63 | 8 | 10855 | 2170 | 90615414 |
| Oral fungal infection | 19.44 | 15.63 | 9 | 10854 | 3323 | 90614261 |
| Hepatitis B core antibody positive | 18.93 | 15.63 | 5 | 10858 | 346 | 90617238 |
| Varicella | 18.89 | 15.63 | 8 | 10855 | 2394 | 90615190 |
| Alopecia | 18.78 | 15.63 | 19 | 10844 | 495052 | 90122532 |
| Headache | 18.63 | 15.63 | 171 | 10692 | 862575 | 89755009 |
| Torticollis | 18.40 | 15.63 | 8 | 10855 | 2550 | 90615034 |
| Lower respiratory tract infection | 18.01 | 15.63 | 4 | 10859 | 250655 | 90366929 |
| Gastric infection | 17.92 | 15.63 | 9 | 10854 | 3971 | 90613613 |
| Listeriosis | 17.79 | 15.63 | 7 | 10856 | 1736 | 90615848 |
| Psoriatic arthropathy | 17.76 | 15.63 | 3 | 10860 | 228332 | 90389252 |
| Ophthalmic herpes zoster | 17.74 | 15.63 | 8 | 10855 | 2780 | 90614804 |
| Osmophobia | 17.61 | 15.63 | 4 | 10859 | 147 | 90617437 |
| Transfusion-related circulatory overload | 17.43 | 15.63 | 4 | 10859 | 154 | 90617430 |
| Chronic inflammatory demyelinating polyradiculoneuropathy | 17.33 | 15.63 | 6 | 10857 | 1041 | 90616543 |
| Joint swelling | 17.24 | 15.63 | 21 | 10842 | 503279 | 90114305 |
| Lack of infusion site rotation | 17.21 | 15.63 | 4 | 10859 | 163 | 90617421 |
| Condition aggravated | 17.12 | 15.63 | 126 | 10737 | 595419 | 90022165 |
| SARS-CoV-2 test negative | 16.73 | 15.63 | 5 | 10858 | 543 | 90617041 |
| Enteritis | 16.51 | 15.63 | 12 | 10851 | 10309 | 90607275 |
| Cartilage injury | 16.43 | 15.63 | 7 | 10856 | 2124 | 90615460 |
| Increased bronchial secretion | 16.36 | 15.63 | 7 | 10856 | 2146 | 90615438 |
| Impaired healing | 16.31 | 15.63 | 4 | 10859 | 234195 | 90383389 |
| No adverse event | 15.98 | 15.63 | 29 | 10834 | 67953 | 90549631 |
| Thermal burn | 15.94 | 15.63 | 10 | 10853 | 6752 | 90610832 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Myasthenia gravis crisis | 335.12 | 16.48 | 65 | 6929 | 781 | 42613560 |
| Myasthenia gravis | 333.64 | 16.48 | 118 | 6876 | 16019 | 42598322 |
| Eyelid ptosis | 189.73 | 16.48 | 62 | 6932 | 6599 | 42607742 |
| Diplopia | 125.75 | 16.48 | 63 | 6931 | 20253 | 42594088 |
| Off label use | 60.87 | 16.48 | 235 | 6759 | 638100 | 41976241 |
| Myasthenic syndrome | 55.84 | 16.48 | 15 | 6979 | 806 | 42613535 |
| Muscular weakness | 48.53 | 16.48 | 64 | 6930 | 83434 | 42530907 |
| Respiratory failure | 48.18 | 16.48 | 80 | 6914 | 128052 | 42486289 |
| Intestinal transit time decreased | 47.52 | 16.48 | 9 | 6985 | 94 | 42614247 |
| Glucose tolerance impaired | 41.75 | 16.48 | 18 | 6976 | 4106 | 42610235 |
| Histoplasmosis | 36.60 | 16.48 | 13 | 6981 | 1774 | 42612567 |
| Product residue present | 34.11 | 16.48 | 14 | 6980 | 2827 | 42611514 |
| Osteoporosis | 33.29 | 16.48 | 24 | 6970 | 14882 | 42599459 |
| Thymoma | 32.13 | 16.48 | 7 | 6987 | 153 | 42614188 |
| Ocular myasthenia | 32.09 | 16.48 | 9 | 6985 | 568 | 42613773 |
| Drug ineffective | 31.42 | 16.48 | 193 | 6801 | 630004 | 41984337 |
| Morvan syndrome | 30.53 | 16.48 | 5 | 6989 | 20 | 42614321 |
| Ophthalmoplegia | 30.42 | 16.48 | 12 | 6982 | 2188 | 42612153 |
| Blood bromide increased | 28.06 | 16.48 | 5 | 6989 | 36 | 42614305 |
| Wrong patient received product | 27.85 | 16.48 | 13 | 6981 | 3570 | 42610771 |
| Dysphagia | 26.74 | 16.48 | 45 | 6949 | 72674 | 42541667 |
| Cholinergic syndrome | 26.40 | 16.48 | 8 | 6986 | 663 | 42613678 |
| Eye luxation | 26.15 | 16.48 | 4 | 6990 | 9 | 42614332 |
| Asthenia | 25.36 | 16.48 | 102 | 6892 | 280691 | 42333650 |
| Meningitis aseptic | 22.25 | 16.48 | 12 | 6982 | 4470 | 42609871 |
| Salivary hypersecretion | 20.81 | 16.48 | 16 | 6978 | 10927 | 42603414 |
| Myiasis | 20.77 | 16.48 | 4 | 6990 | 46 | 42614295 |
| Cerebral toxoplasmosis | 20.72 | 16.48 | 9 | 6985 | 2089 | 42612252 |
| Myopathy | 19.59 | 16.48 | 17 | 6977 | 13744 | 42600597 |
| Lip swelling | 18.43 | 16.48 | 19 | 6975 | 19034 | 42595307 |
| Faecal vomiting | 17.92 | 16.48 | 6 | 6988 | 686 | 42613655 |
| Respiratory muscle weakness | 16.96 | 16.48 | 4 | 6990 | 126 | 42614215 |
| Rebound effect | 16.74 | 16.48 | 12 | 6982 | 7367 | 42606974 |
| Symptom recurrence | 16.73 | 16.48 | 7 | 6987 | 1483 | 42612858 |
| Rash scarlatiniform | 16.50 | 16.48 | 4 | 6990 | 142 | 42614199 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Myasthenia gravis | 944.17 | 14.23 | 270 | 15507 | 21241 | 110552281 |
| Myasthenia gravis crisis | 773.55 | 14.23 | 145 | 15632 | 1669 | 110571853 |
| Eyelid ptosis | 255.45 | 14.23 | 89 | 15688 | 13238 | 110560284 |
| Diplopia | 174.00 | 14.23 | 95 | 15682 | 41799 | 110531723 |
| Off label use | 160.50 | 14.23 | 522 | 15255 | 1499663 | 109073859 |
| Thymoma | 113.72 | 14.23 | 23 | 15754 | 401 | 110573121 |
| Myasthenic syndrome | 93.36 | 14.23 | 24 | 15753 | 1252 | 110572270 |
| Glucose tolerance impaired | 75.81 | 14.23 | 34 | 15743 | 9803 | 110563719 |
| Drug ineffective | 68.49 | 14.23 | 409 | 15368 | 1520131 | 109053391 |
| Dysphagia | 66.43 | 14.23 | 95 | 15682 | 153505 | 110420017 |
| Respiratory failure | 65.12 | 14.23 | 113 | 15664 | 215219 | 110358303 |
| Ocular myasthenia | 58.71 | 14.23 | 15 | 15762 | 763 | 110572759 |
| Muscular weakness | 58.37 | 14.23 | 117 | 15660 | 248351 | 110325171 |
| Cerebral toxoplasmosis | 56.42 | 14.23 | 20 | 15757 | 3122 | 110570400 |
| Cholinergic syndrome | 55.13 | 14.23 | 16 | 15761 | 1316 | 110572206 |
| Wrong patient received product | 51.21 | 14.23 | 23 | 15754 | 6651 | 110566871 |
| Intestinal transit time decreased | 46.62 | 14.23 | 9 | 15768 | 122 | 110573400 |
| Drug ineffective for unapproved indication | 46.50 | 14.23 | 65 | 15712 | 102773 | 110470749 |
| Meningitis aseptic | 45.48 | 14.23 | 24 | 15753 | 9846 | 110563676 |
| Rebound effect | 41.40 | 14.23 | 26 | 15751 | 14780 | 110558742 |
| Bradycardia | 39.85 | 14.23 | 76 | 15701 | 155441 | 110418081 |
| Ophthalmoplegia | 39.76 | 14.23 | 16 | 15761 | 3534 | 110569988 |
| Adiposis dolorosa | 38.77 | 14.23 | 9 | 15768 | 305 | 110573217 |
| Salivary hypersecretion | 37.54 | 14.23 | 26 | 15751 | 17395 | 110556127 |
| Speech disorder | 35.72 | 14.23 | 44 | 15733 | 61525 | 110511997 |
| COVID-19 | 34.04 | 14.23 | 94 | 15683 | 244966 | 110328556 |
| Nocardiosis | 33.92 | 14.23 | 18 | 15759 | 7468 | 110566054 |
| Therapy non-responder | 33.29 | 14.23 | 71 | 15706 | 157236 | 110416286 |
| Bulbar palsy | 32.33 | 14.23 | 8 | 15769 | 357 | 110573165 |
| Product residue present | 31.58 | 14.23 | 14 | 15763 | 3927 | 110569595 |
| Morvan syndrome | 31.23 | 14.23 | 5 | 15772 | 20 | 110573502 |
| Blood pressure increased | 30.96 | 14.23 | 94 | 15683 | 258279 | 110315243 |
| Postural orthostatic tachycardia syndrome | 30.11 | 14.23 | 11 | 15766 | 1871 | 110571651 |
| Asthenia | 29.26 | 14.23 | 183 | 15594 | 688816 | 109884706 |
| Dysarthria | 29.20 | 14.23 | 47 | 15730 | 84074 | 110489448 |
| Blood bromide increased | 28.76 | 14.23 | 5 | 15772 | 36 | 110573486 |
| Histoplasmosis | 28.62 | 14.23 | 12 | 15765 | 2941 | 110570581 |
| Arteriospasm coronary | 28.03 | 14.23 | 17 | 15760 | 9083 | 110564439 |
| Respiratory distress | 27.43 | 14.23 | 41 | 15736 | 68833 | 110504689 |
| Oromandibular dystonia | 26.70 | 14.23 | 9 | 15768 | 1210 | 110572312 |
| Suspected COVID-19 | 26.68 | 14.23 | 12 | 15765 | 3481 | 110570041 |
| Pulmonary nocardiosis | 26.54 | 14.23 | 11 | 15766 | 2618 | 110570904 |
| Diaphragmatic paralysis | 26.17 | 14.23 | 9 | 15768 | 1285 | 110572237 |
| Osteopenia | 25.77 | 14.23 | 23 | 15754 | 22186 | 110551336 |
| Eye luxation | 25.19 | 14.23 | 4 | 15773 | 15 | 110573507 |
| Sensory disturbance | 24.19 | 14.23 | 20 | 15757 | 17409 | 110556113 |
| Antiacetylcholine receptor antibody positive | 24.11 | 14.23 | 6 | 15771 | 274 | 110573248 |
| Atrioventricular block complete | 23.71 | 14.23 | 21 | 15756 | 20061 | 110553461 |
| Thymectomy | 23.57 | 14.23 | 3 | 15774 | 0 | 110573522 |
| Menopause | 23.55 | 14.23 | 10 | 15767 | 2528 | 110570994 |
| Arthropathy | 23.52 | 14.23 | 6 | 15771 | 287516 | 110286006 |
| Symptom recurrence | 23.12 | 14.23 | 12 | 15765 | 4760 | 110568762 |
| Therapy partial responder | 22.33 | 14.23 | 27 | 15750 | 37034 | 110536488 |
| Congenital myasthenic syndrome | 21.49 | 14.23 | 3 | 15774 | 3 | 110573519 |
| Acute on chronic liver failure | 21.48 | 14.23 | 6 | 15771 | 430 | 110573092 |
| No adverse event | 21.31 | 14.23 | 38 | 15739 | 73801 | 110499721 |
| Pericarditis | 21.25 | 14.23 | 3 | 15774 | 219111 | 110354411 |
| Myiasis | 21.02 | 14.23 | 4 | 15773 | 50 | 110573472 |
| Neutropenia | 20.74 | 14.23 | 14 | 15763 | 374606 | 110198916 |
| Borderline leprosy | 20.47 | 14.23 | 4 | 15773 | 58 | 110573464 |
| Blister | 20.09 | 14.23 | 4 | 15773 | 227372 | 110346150 |
| Lower respiratory tract infection | 20.03 | 14.23 | 5 | 15772 | 243101 | 110330421 |
| Pneumonia aspiration | 19.94 | 14.23 | 39 | 15738 | 81194 | 110492328 |
| Systemic lupus erythematosus | 19.52 | 14.23 | 6 | 15771 | 254332 | 110319190 |
| Brain abscess | 19.20 | 14.23 | 12 | 15765 | 6762 | 110566760 |
| Psoriatic arthropathy | 18.38 | 14.23 | 3 | 15774 | 196758 | 110376764 |
| Irritability | 18.38 | 14.23 | 28 | 15749 | 47781 | 110525741 |
| Condition aggravated | 18.14 | 14.23 | 172 | 15605 | 734664 | 109838858 |
| Acute kidney injury | 18.01 | 14.23 | 40 | 15737 | 635390 | 109938132 |
| Stomatitis | 18.00 | 14.23 | 8 | 15769 | 270234 | 110303288 |
| Hepatitis B surface antibody positive | 17.97 | 14.23 | 5 | 15772 | 353 | 110573169 |
| Cyanopsia | 17.97 | 14.23 | 4 | 15773 | 112 | 110573410 |
| Sinoatrial block | 17.79 | 14.23 | 7 | 15770 | 1458 | 110572064 |
| Solar lentigo | 17.52 | 14.23 | 7 | 15770 | 1517 | 110572005 |
| Respiratory muscle weakness | 17.18 | 14.23 | 5 | 15772 | 415 | 110573107 |
| Wound | 17.16 | 14.23 | 6 | 15771 | 234431 | 110339091 |
| Osmophobia | 17.14 | 14.23 | 4 | 15773 | 139 | 110573383 |
| Coma | 17.13 | 14.23 | 46 | 15731 | 117823 | 110455699 |
| Drug effective for unapproved indication | 17.09 | 14.23 | 15 | 15762 | 14152 | 110559370 |
| Platelet count decreased | 16.69 | 14.23 | 6 | 15771 | 230437 | 110343085 |
| Myocardial necrosis marker increased | 16.65 | 14.23 | 9 | 15768 | 3871 | 110569651 |
| Lack of infusion site rotation | 16.64 | 14.23 | 4 | 15773 | 158 | 110573364 |
| Myopathy | 16.38 | 14.23 | 19 | 15758 | 24941 | 110548581 |
| Listeriosis | 16.34 | 14.23 | 8 | 15769 | 2806 | 110570716 |
| Wheezing | 16.31 | 14.23 | 8 | 15769 | 255222 | 110318300 |
| Impaired healing | 16.29 | 14.23 | 4 | 15773 | 196713 | 110376809 |
| Product substitution issue | 15.89 | 14.23 | 18 | 15759 | 23043 | 110550479 |
| Dropped head syndrome | 15.87 | 14.23 | 5 | 15772 | 543 | 110572979 |
| Gastric infection | 15.86 | 14.23 | 9 | 15768 | 4257 | 110569265 |
| Oral fungal infection | 15.50 | 14.23 | 9 | 15768 | 4443 | 110569079 |
| Respiratory acidosis | 15.41 | 14.23 | 14 | 15763 | 13812 | 110559710 |
| Torticollis | 15.32 | 14.23 | 8 | 15769 | 3213 | 110570309 |
| Thermal burn | 15.08 | 14.23 | 11 | 15766 | 7977 | 110565545 |
| Chronic inflammatory demyelinating polyradiculoneuropathy | 15.06 | 14.23 | 7 | 15770 | 2188 | 110571334 |
| Joint swelling | 15.05 | 14.23 | 25 | 15752 | 442820 | 110130702 |
| Hepatitis B core antibody positive | 14.96 | 14.23 | 5 | 15772 | 654 | 110572868 |
| Diabetes mellitus | 14.66 | 14.23 | 39 | 15738 | 99342 | 110474180 |
None
| Source | Code | Description |
|---|---|---|
| ATC | N07AA02 | NERVOUS SYSTEM OTHER NERVOUS SYSTEM DRUGS PARASYMPATHOMIMETICS Anticholinesterases |
| FDA MoA | N0000000177 | Cholinesterase Inhibitors |
| MeSH PA | D002800 | Cholinesterase Inhibitors |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018678 | Cholinergic Agents |
| FDA EPC | N0000175723 | Cholinesterase Inhibitor |
| CHEBI has role | CHEBI:35526 | hypoglycemic agent |
| CHEBI has role | CHEBI:50514 | vasoconstrictor agent |
| CHEBI has role | CHEBI:64946 | anti-HIV agent |
| CHEBI has role | CHEBI:22587 | antiviral agent |
| CHEBI has role | CHEBI:35554 | cardiovascular drug |
| CHEBI has role | CHEBI:48407 | antiparkinson drug |
| CHEBI has role | CHEBI:55324 | gastrointestinal drug |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Myasthenia gravis | indication | 91637004 | DOID:437 |
| Neuromuscular Block due to Nondepolarizing Drug | indication | ||
| Prevention of Nerve Agent Poisoning | indication | ||
| Urinary tract obstruction | contraindication | 7163005 | DOID:5200 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Gastrointestinal obstruction | contraindication | 126765001 | |
| Asthma | contraindication | 195967001 | DOID:2841 |
None
None
None
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
|---|---|---|---|---|---|---|---|---|---|---|
| 105MG | PYRIDOSTIGMINE BROMIDE | AMNEAL | N217604 | Oct. 4, 2024 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 11478425 | June 18, 2038 | PRETREATMENT AGAINST THE LETHAL EFFECTS OF SOMAN NERVE AGENT POISONING |
None
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Acetylcholinesterase | Enzyme | INHIBITOR | IC50 | 6.44 | CHEMBL | CHEMBL | |||
| Cholinesterase | Enzyme | Ki | 5.46 | CHEMBL | |||||
| Acetylcholinesterase | Enzyme | IC50 | 7.09 | CHEMBL | |||||
| Acetylcholinesterase | Enzyme | Ki | 4.71 | CHEMBL |
| ID | Source |
|---|---|
| 4019921 | VUID |
| N0000148006 | NUI |
| D00487 | KEGG_DRUG |
| 101-26-8 | SECONDARY_CAS_RN |
| 4017783 | VANDF |
| 4019921 | VANDF |
| C0034261 | UMLSCUI |
| CHEBI:8665 | CHEBI |
| CHEMBL1115 | ChEMBL_ID |
| DB00545 | DRUGBANK_ID |
| CHEMBL812 | ChEMBL_ID |
| D011729 | MESH_DESCRIPTOR_UI |
| 4991 | PUBCHEM_CID |
| 8994 | IUPHAR_LIGAND_ID |
| 19QM69HH21 | UNII |
| 9000 | RXNORM |
| 46043 | MMSL |
| 5392 | MMSL |
| d00363 | MMSL |
| 001707 | NDDF |
| 004687 | NDDF |
| 34915005 | SNOMEDCT_US |
| 373344003 | SNOMEDCT_US |
| 59953007 | SNOMEDCT_US |
| 4685-03-4 | SECONDARY_CAS_RN |
| 278 | INN_ID |
| 19QM69HH21 | INXIGHT DRUGS |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Pyridostigmine Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1404 | TABLET, EXTENDED RELEASE | 180 mg | ORAL | ANDA | 12 sections |
| Pyridostigmine Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-2134 | TABLET | 30 mg | ORAL | ANDA | 11 sections |
| Pyridostigmine Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-3511 | TABLET | 60 mg | ORAL | ANDA | 11 sections |
| Pyridostigmine Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-3511 | TABLET | 60 mg | ORAL | ANDA | 11 sections |
| Mestinon | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-3010 | TABLET | 60 mg | ORAL | NDA | 15 sections |
| Mestinon | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-3012 | SOLUTION | 60 mg | ORAL | NDA | 15 sections |
| Mestinon | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-3013 | TABLET, EXTENDED RELEASE | 180 mg | ORAL | NDA | 15 sections |
| Regonol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-3040 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | NDA | 19 sections |
| pyridostigmine bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6622 | TABLET | 60 mg | ORAL | ANDA | 11 sections |
| Pryidostigmine Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16571-833 | SOLUTION | 60 mg | ORAL | ANDA | 11 sections |
| PRYIDOSTIGMINE BROMIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24689-104 | SOLUTION | 60 mg | ORAL | ANDA | 14 sections |
| Pyridostigmine Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42192-626 | SOLUTION | 60 mg | ORAL | ANDA | 14 sections |
| Pyridostigmine Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 47781-335 | TABLET, EXTENDED RELEASE | 180 mg | ORAL | ANDA | 12 sections |
| Pyridostigmine Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 47781-335 | TABLET, EXTENDED RELEASE | 180 mg | ORAL | ANDA | 12 sections |
| pyridostigmine bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51407-590 | TABLET | 60 mg | ORAL | ANDA | 11 sections |
| Pyridostigmine Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 58657-810 | TABLET | 30 mg | ORAL | ANDA | 13 sections |
| Pyridostigmine Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 58657-810 | TABLET | 30 mg | ORAL | ANDA | 13 sections |
| Pyridostigmine Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 58657-811 | TABLET | 60 mg | ORAL | ANDA | 13 sections |
| Pyridostigmine bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60846-559 | TABLET, EXTENDED RELEASE | 105 mg | ORAL | NDA | 29 sections |
| Pyridostigmine Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 62559-470 | TABLET | 60 mg | ORAL | ANDA | 13 sections |
| Pyridostigmine Bromide | Human Prescription Drug Label | 1 | 64980-220 | TABLET | 180 mg | ORAL | ANDA | 9 sections |
| pyridostigmine bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 65841-819 | TABLET | 60 mg | ORAL | ANDA | 11 sections |
| Pyridostigmine Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 66689-406 | SOLUTION | 60 mg | ORAL | ANDA | 12 sections |
| Pyridostigmine Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68084-494 | TABLET | 60 mg | ORAL | ANDA | 15 sections |
| pyridostigmine bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68382-659 | TABLET | 60 mg | ORAL | ANDA | 11 sections |
| pyridostigmine bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68682-301 | TABLET, EXTENDED RELEASE | 180 mg | ORAL | NDA authorized generic | 12 sections |
| Pyridostigmine Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68682-302 | TABLET | 60 mg | ORAL | NDA authorized generic | 12 sections |
| pyridostigmine bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68682-307 | SOLUTION | 60 mg | ORAL | NDA authorized generic | 15 sections |
| Pyridostigmine Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 69238-1731 | SOLUTION | 60 mg | ORAL | ANDA | 11 sections |
| Pyridostigmine | Human Prescription Drug Label | 1 | 70954-148 | SOLUTION | 60 mg | ORAL | ANDA | 13 sections |