protokylol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	2318	136-70-9

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

protochilolo
protokylol
caytine
protochylol
ventaire
protokylol hydrochloride
JB-251
protokylol HCl
asmetil

Molecular weight: 331.37
Formula: C18H21NO5
CLOGP: 1.69
LIPINSKI: 0
HAC: 6
HDO: 4
TPSA: 91.18
ALOGS: -3.15
ROTB: 6

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA	SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.97	acidic
pKa2	12.82	acidic
pKa3	13.52	acidic
pKa4	8.15	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Beta-2 adrenergic receptor	GPCR	P07550	ADRB2_HUMAN	AGONIST				CHEMBL	CHEMBL

External reference:

ID	Source
C0163026	UMLSCUI
CHEBI:135413	CHEBI
CHEMBL1201273	ChEMBL_ID
CHEMBL1200893	ChEMBL_ID
DB06814	DRUGBANK_ID
C010312	MESH_SUPPLEMENTAL_RECORD_UI
4969	PUBCHEM_CID
920	INN_ID
136-69-6	SECONDARY_CAS_RN
8Y5Y4EEO2V	UNII
001781	NDDF
004719	NDDF
6260007	SNOMEDCT_US
782180003	SNOMEDCT_US

Pharmaceutical products:

None