propranolol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 2303 525-66-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • propranolol
  • betalong
  • DL-Propranolol
  • racemic propranolol
  • beta-Propranolol
  • propranolol hydrochloride
  • hemangiol
  • propranolol HCl
A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
  • Molecular weight: 259.35
  • Formula: C16H21NO2
  • CLOGP: 2.75
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 41.49
  • ALOGS: -3.51
  • ROTB: 6
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.16 g O
0.16 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 50 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.25 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 35.25 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 26 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 3.10 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 12 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.13 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.40 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Nov. 13, 1967 FDA BAXTER HLTHCARE CORP

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Product administered to patient of inappropriate age 1151.63 10.08 333 75639 2935 63410115
Completed suicide 788.43 10.08 920 75052 144753 63268297
Toxicity to various agents 409.66 10.08 909 75063 246341 63166709
Bradycardia 397.97 10.08 464 75508 72763 63340287
Drug ineffective for unapproved indication 376.55 10.08 318 75654 33745 63379305
Off label use 351.99 10.08 1664 74308 672798 62740252
Cardiac arrest 286.82 10.08 446 75526 92099 63320951
Infantile spitting up 232.75 10.08 46 75926 44 63413006
Coma 201.86 10.08 312 75660 64052 63348998
Overdose 195.62 10.08 428 75544 114650 63298400
Product use in unapproved indication 175.94 10.08 542 75430 178538 63234512
Intentional overdose 175.71 10.08 317 75655 73835 63339215
Hand deformity 171.58 10.08 4 75968 159453 63253597
Glossodynia 170.67 10.08 11 75961 178865 63234185
Inappropriate schedule of product administration 170.27 10.08 381 75591 103584 63309466
Systemic lupus erythematosus 167.77 10.08 25 75947 208893 63204157
Hypotension 165.48 10.08 705 75267 271899 63141151
Cardio-respiratory arrest 165.17 10.08 274 75698 59685 63353365
Wound 158.89 10.08 9 75963 163254 63249796
Ulcerated haemangioma 148.97 10.08 26 75946 0 63413050
Drug interaction 138.52 10.08 592 75380 228539 63184511
Product use issue 137.38 10.08 575 75397 219945 63193105
Pericarditis 132.00 10.08 6 75966 131573 63281477
Peripheral coldness 123.05 10.08 108 75864 12057 63400993
Electrocardiogram QRS complex prolonged 120.83 10.08 80 75892 5858 63407192
Joint swelling 120.14 10.08 129 75843 327537 63085513
Respiratory arrest 114.79 10.08 167 75805 32478 63380572
Swelling 113.03 10.08 98 75874 275280 63137770
Sinus bradycardia 106.56 10.08 108 75864 14443 63398607
Alopecia 101.82 10.08 154 75818 337382 63075668
Electrocardiogram QT prolonged 99.46 10.08 220 75752 59310 63353740
Cardiogenic shock 97.91 10.08 114 75858 17818 63395232
Helicobacter infection 97.27 10.08 3 75969 92782 63320268
Suicidal ideation 96.85 10.08 224 75748 62197 63350853
Hypoglycaemia 95.90 10.08 218 75754 59847 63353203
Lower respiratory tract infection 95.02 10.08 21 75951 132286 63280764
Suicide attempt 92.75 10.08 217 75755 60701 63352349
Seizure 91.37 10.08 357 75615 132277 63280773
Pulseless electrical activity 88.84 10.08 73 75899 7448 63405602
Rheumatoid arthritis 88.53 10.08 104 75868 253715 63159335
Synovitis 87.57 10.08 58 75914 186860 63226190
Neovascularisation 83.05 10.08 36 75936 1109 63411941
Circulatory collapse 82.67 10.08 116 75856 21822 63391228
Brain injury 80.35 10.08 67 75905 6976 63406074
Arthropathy 79.96 10.08 98 75874 234694 63178356
Poisoning deliberate 79.85 10.08 82 75890 11136 63401914
Infection 79.80 10.08 94 75878 229079 63183971
Arthralgia 78.48 10.08 383 75589 569327 62843723
Paradoxical drug reaction 77.45 10.08 53 75919 4099 63408951
Abdominal discomfort 77.41 10.08 168 75804 320717 63092333
Extrapyramidal disorder 73.44 10.08 85 75887 13199 63399851
Pain 69.42 10.08 561 75411 740067 62672983
Thyrotoxic crisis 68.34 10.08 29 75943 847 63412203
Discomfort 68.09 10.08 60 75912 167314 63245736
Infusion related reaction 67.45 10.08 119 75853 245402 63167648
Anuria 67.20 10.08 79 75893 12472 63400578
Sleep terror 66.70 10.08 41 75931 2639 63410411
Impaired healing 64.70 10.08 21 75951 102521 63310529
Nightmare 64.31 10.08 96 75876 19098 63393952
Somnolence 63.96 10.08 399 75573 178286 63234764
Migraine 63.85 10.08 269 75703 103077 63309973
Folliculitis 62.34 10.08 6 75966 70311 63342739
Drug withdrawal syndrome 61.51 10.08 114 75858 27080 63385970
Stomatitis 61.06 10.08 46 75926 138679 63274371
Phaeochromocytoma 60.70 10.08 23 75949 496 63412554
Blister 55.92 10.08 44 75928 129770 63283280
Shock 55.14 10.08 100 75872 23363 63389687
Peripheral swelling 54.85 10.08 151 75821 265791 63147259
Hepatic enzyme increased 54.71 10.08 99 75873 202229 63210821
Hypoglycaemic seizure 54.65 10.08 21 75951 471 63412579
Therapeutic product effect decreased 54.53 10.08 92 75880 193095 63219955
Tremor 54.18 10.08 306 75666 131933 63281117
Respiratory depression 53.88 10.08 74 75898 13641 63399409
Hyperthyroidism 51.48 10.08 75 75897 14598 63398452
Retinal detachment 50.60 10.08 48 75924 5921 63407129
Metabolic acidosis 50.43 10.08 143 75829 44926 63368124
Nasopharyngitis 49.76 10.08 148 75824 254109 63158941
Hepatic encephalopathy 49.11 10.08 64 75908 11218 63401832
Sinusitis 48.76 10.08 126 75846 226527 63186523
Fatigue 48.16 10.08 761 75211 887267 62525783
Sleep disorder due to general medical condition, insomnia type 47.51 10.08 4 75968 52213 63360837
Maternal exposure during pregnancy 46.83 10.08 123 75849 219939 63193111
Disease progression 46.40 10.08 47 75925 122711 63290339
Irritability 46.16 10.08 111 75861 31583 63381467
Rash 46.15 10.08 439 75533 560432 62852618
Contraindicated product administered 45.29 10.08 123 75849 217525 63195525
Suspected suicide 44.93 10.08 47 75925 6521 63406529
Mobility decreased 43.98 10.08 48 75924 121111 63291939
Brain death 42.17 10.08 34 75938 3376 63409674
Disturbance in attention 41.59 10.08 120 75852 38069 63374981
Somatic delusion 40.94 10.08 18 75954 574 63412476
Galactorrhoea 40.25 10.08 36 75936 4119 63408931
Agitation 39.62 10.08 159 75813 59598 63353452
Depression 39.14 10.08 383 75589 196109 63216941
Pyrexia 38.77 10.08 368 75604 470110 62942940
Electrocardiogram QRS complex shortened 38.17 10.08 16 75956 453 63412597
Depressed level of consciousness 37.87 10.08 161 75811 61917 63351133
Panic attack 37.81 10.08 83 75889 22248 63390802
Hyperhidrosis 36.81 10.08 238 75734 107598 63305452
Pain in extremity 36.74 10.08 239 75733 331247 63081803
Gastrointestinal disorder 36.56 10.08 63 75909 131176 63281874
Loss of consciousness 35.72 10.08 253 75719 117868 63295182
Akathisia 35.41 10.08 49 75923 9097 63403953
Ill-defined disorder 34.83 10.08 28 75944 81727 63331323
Knee arthroplasty 34.37 10.08 11 75961 54195 63358855
Generalised tonic-clonic seizure 34.36 10.08 94 75878 28922 63384128
Intentional product use issue 34.18 10.08 63 75909 127829 63285221
Migraine with aura 33.21 10.08 27 75945 2713 63410337
Insulin autoimmune syndrome 33.08 10.08 10 75962 104 63412946
Sleep disorder 32.90 10.08 188 75784 81378 63331672
Swollen tongue 32.86 10.08 104 75868 34696 63378354
Pneumonia 32.81 10.08 369 75603 456398 62956652
Hip arthroplasty 31.42 10.08 9 75963 47637 63365413
Atrioventricular block first degree 31.26 10.08 41 75931 7232 63405818
Vascular malformation 31.05 10.08 13 75959 367 63412683
Irritable bowel syndrome 30.63 10.08 32 75940 82380 63330670
Hallucination, auditory 30.56 10.08 55 75917 12769 63400281
Insomnia 30.32 10.08 392 75580 214860 63198190
Hallucination 30.27 10.08 138 75834 54679 63358371
Coma scale abnormal 30.22 10.08 34 75938 5119 63407931
Serotonin syndrome 30.15 10.08 89 75883 28593 63384457
Neuropathy peripheral 29.48 10.08 57 75915 113610 63299440
Foetal alcohol syndrome 29.28 10.08 7 75965 26 63413024
Atrioventricular block 28.16 10.08 40 75932 7607 63405443
Negative symptoms in schizophrenia 28.10 10.08 9 75963 115 63412935
Myocardial oedema 27.00 10.08 10 75962 202 63412848
Paranasal cyst 26.94 10.08 12 75960 395 63412655
Distributive shock 26.62 10.08 18 75954 1365 63411685
Musculoskeletal stiffness 26.54 10.08 122 75850 184496 63228554
Ear infection 26.39 10.08 103 75869 38110 63374940
Teething 26.34 10.08 6 75966 17 63413033
Vision blurred 26.12 10.08 194 75778 91730 63321320
Withdrawal syndrome 25.93 10.08 67 75905 19930 63393120
Type 2 diabetes mellitus 25.83 10.08 23 75949 63845 63349205
Oesophageal obstruction 25.75 10.08 13 75959 569 63412481
Anxiety 25.70 10.08 384 75588 217157 63195893
Mydriasis 25.64 10.08 49 75923 11907 63401143
Death 25.48 10.08 306 75666 374075 63038975
Herpes zoster 25.41 10.08 37 75935 82425 63330625
Hyperthermia 25.40 10.08 42 75930 9114 63403936
Hyperammonaemic encephalopathy 25.40 10.08 22 75950 2412 63410638
Hepatocellular carcinoma 25.29 10.08 21 75951 2173 63410877
Cerebral disorder 25.08 10.08 29 75943 4497 63408553
Eosinophilic myocarditis 24.97 10.08 13 75959 607 63412443
Accessory cardiac pathway 24.71 10.08 5 75967 6 63413044
Derailment 24.58 10.08 7 75965 58 63412992
General physical health deterioration 24.49 10.08 141 75831 201261 63211789
Productive cough 24.10 10.08 24 75948 63184 63349866
Haemoglobin decreased 24.10 10.08 91 75881 145394 63267656
Mental disorder 24.05 10.08 77 75895 25842 63387208
Infusion site streaking 24.03 10.08 12 75960 513 63412537
Blood prolactin increased 23.84 10.08 25 75947 3478 63409572
Febrile neutropenia 23.83 10.08 68 75904 118381 63294669
Hypothermia 23.59 10.08 51 75921 13530 63399520
Thyroxine free decreased 23.52 10.08 13 75959 685 63412365
Palpitations 23.51 10.08 222 75750 112548 63300502
Distractibility 22.87 10.08 11 75961 433 63412617
Granuloma skin 22.47 10.08 38 75934 8399 63404651
Varices oesophageal 22.38 10.08 23 75949 3125 63409925
Pleural effusion 22.26 10.08 49 75923 93161 63319889
Cyanosis 22.22 10.08 57 75915 16878 63396172
Antipsychotic drug level decreased 22.07 10.08 10 75962 343 63412707
Oedema 21.96 10.08 53 75919 97569 63315481
Interstitial lung disease 21.94 10.08 25 75947 61883 63351167
Torsade de pointes 21.90 10.08 49 75923 13302 63399748
Hyperreflexia 21.79 10.08 31 75941 5903 63407147
Hyperprolactinaemia 21.63 10.08 25 75947 3875 63409175
Narrow anterior chamber angle 21.36 10.08 6 75966 47 63413003
Poor quality sleep 21.08 10.08 62 75910 19873 63393177
Haematemesis 21.02 10.08 82 75890 30330 63382720
Lip swelling 20.86 10.08 83 75889 30980 63382070
Dizziness 20.82 10.08 667 75305 429258 62983792
Dystonia 20.77 10.08 49 75923 13770 63399280
Urine amphetamine positive 20.63 10.08 6 75966 54 63412996
Chemical burn 20.30 10.08 10 75962 415 63412635
Middle insomnia 20.29 10.08 46 75926 12597 63400453
Adrenal suppression 20.15 10.08 13 75959 911 63412139
Retroperitoneal fibrosis 20.10 10.08 9 75963 300 63412750
Acquired porphyria 20.06 10.08 5 75967 23 63413027
Porphyrins urine increased 20.06 10.08 5 75967 23 63413027
Pituitary apoplexy 19.65 10.08 7 75965 126 63412924
Blood cholesterol increased 19.64 10.08 53 75919 93979 63319071
Hallucination, visual 19.45 10.08 59 75913 19239 63393811
Therapeutic product ineffective for unapproved indication 19.37 10.08 8 75964 218 63412832
Cerebral vasoconstriction 19.24 10.08 14 75958 1194 63411856
Depressed mood 19.16 10.08 97 75875 40094 63372956
Ventricular tachycardia 19.13 10.08 60 75912 19919 63393131
Feeling abnormal 19.12 10.08 266 75706 148126 63264924
Cholestasis of pregnancy 19.06 10.08 14 75958 1211 63411839
Drug titration error 18.99 10.08 12 75960 811 63412239
Hypermobility syndrome 18.99 10.08 12 75960 811 63412239
Oesophageal varices haemorrhage 18.97 10.08 14 75958 1220 63411830
Porphyrins stool increased 18.95 10.08 5 75967 30 63413020
Neutropenia 18.94 10.08 127 75845 174878 63238172
Product administration interrupted 18.86 10.08 26 75946 4810 63408240
Hypersensitivity 18.85 10.08 242 75730 292443 63120607
Ventricular arrhythmia 18.70 10.08 23 75949 3805 63409245
Myocardial depression 18.69 10.08 10 75962 494 63412556
Panic reaction 18.67 10.08 24 75948 4150 63408900
Blood parathyroid hormone decreased 18.43 10.08 38 75934 9753 63403297
Tardive dyskinesia 18.42 10.08 35 75937 8467 63404583
Joint range of motion decreased 18.18 10.08 8 75964 32420 63380630
Lethargy 18.12 10.08 122 75850 55885 63357165
Apraxia 18.08 10.08 16 75956 1805 63411245
Acute lung injury 18.03 10.08 15 75957 1556 63411494
Muscle contractions involuntary 17.96 10.08 18 75954 2374 63410676
Poisoning 17.86 10.08 46 75926 13654 63399396
Perseveration 17.86 10.08 8 75964 267 63412783
Fibromyalgia 17.82 10.08 44 75928 80376 63332674
Teratogenicity 17.80 10.08 8 75964 269 63412781
Dyspnoea 17.64 10.08 631 75341 660682 62752368
Laryngeal dyspnoea 17.58 10.08 7 75965 173 63412877
Therapeutic product effective for unapproved indication 17.49 10.08 6 75966 96 63412954
Oedema peripheral 17.42 10.08 144 75828 189367 63223683
Thyrotoxic cardiomyopathy 17.19 10.08 3 75969 0 63413050
Bradycardia foetal 17.15 10.08 9 75963 427 63412623
Grip strength decreased 17.12 10.08 3 75969 22284 63390766
Wheezing 17.02 10.08 58 75914 95537 63317513
Hyponatraemic seizure 17.02 10.08 9 75963 434 63412616
Vasoplegia syndrome 17.01 10.08 15 75957 1684 63411366
Chromaturia 16.74 10.08 51 75921 16666 63396384
Panniculitis 16.71 10.08 40 75932 11345 63401705
Dissociation 16.68 10.08 19 75953 2900 63410150
Haemodynamic instability 16.52 10.08 35 75937 9155 63403895
Jaundice 16.41 10.08 74 75898 29177 63383873
Bezoar 16.34 10.08 14 75958 1512 63411538
Mastoiditis 16.29 10.08 12 75960 1043 63412007
Postural orthostatic tachycardia syndrome 16.25 10.08 13 75959 1276 63411774
Psychotic symptom 16.07 10.08 14 75958 1547 63411503
Alcohol interaction 16.05 10.08 17 75955 2392 63410658
Aphasia 15.98 10.08 80 75892 32920 63380130
Accelerated idioventricular rhythm 15.89 10.08 5 75967 60 63412990
Mood swings 15.84 10.08 53 75919 18195 63394855
Gynaecomastia 15.81 10.08 7 75965 227 63412823
Heart rate decreased 15.81 10.08 101 75871 45459 63367591
Exposure via transplant 15.78 10.08 4 75968 20 63413030
Back pain 15.70 10.08 222 75750 263923 63149127
Therapy non-responder 15.69 10.08 43 75929 75858 63337192
Breath sounds abnormal 15.52 10.08 38 75934 10935 63402115
Therapeutic product effect incomplete 15.49 10.08 87 75885 124969 63288081
Wrong patient received product 15.47 10.08 16 75956 2191 63410859
Headache 15.46 10.08 915 75057 632326 62780724
Prescribed overdose 15.44 10.08 11 75961 34142 63378908
Pulse absent 15.38 10.08 25 75947 5349 63407701
Skin necrosis 15.34 10.08 44 75928 13906 63399144
Paraganglion neoplasm 15.31 10.08 4 75968 23 63413027
Cerebellar syndrome 15.28 10.08 20 75952 3519 63409531
Bradypnoea 15.24 10.08 20 75952 3530 63409520
Contusion 15.20 10.08 111 75861 149933 63263117
Defect conduction intraventricular 15.16 10.08 6 75966 146 63412904
Sprue-like enteropathy 15.09 10.08 10 75962 733 63412317
Agoraphobia 15.09 10.08 8 75964 388 63412662
Breath holding 15.08 10.08 6 75966 148 63412902
Gastrointestinal motility disorder 14.90 10.08 24 75948 5095 63407955
Feeling guilty 14.73 10.08 9 75963 573 63412477
Self-injurious ideation 14.67 10.08 17 75955 2642 63410408
Psoriatic arthropathy 14.67 10.08 58 75914 91462 63321588
Lung disorder 14.64 10.08 33 75939 62228 63350822
Metastases to liver 14.63 10.08 5 75967 23634 63389416
Malignant neoplasm progression 14.50 10.08 50 75922 82071 63330979
Musculoskeletal pain 14.46 10.08 59 75913 92218 63320832
Tic 14.39 10.08 13 75959 1507 63411543
Unresponsive to stimuli 14.33 10.08 79 75893 33737 63379313
Liver injury 14.29 10.08 32 75940 60488 63352562
Tumour rupture 14.28 10.08 6 75966 171 63412879
Nervousness 14.23 10.08 74 75898 30905 63382145
Visual field defect 14.20 10.08 27 75945 6534 63406516
Medication overuse headache 14.07 10.08 10 75962 822 63412228
Congenital pharyngeal anomaly 13.90 10.08 3 75969 6 63413044
Essential tremor 13.78 10.08 11 75961 1077 63411973
Food craving 13.78 10.08 13 75959 1593 63411457
Behaviour disorder 13.69 10.08 18 75954 3181 63409869
Extra dose administered 13.58 10.08 26 75946 6324 63406726
Salivary hypersecretion 13.56 10.08 29 75943 7637 63405413
Vertigo 13.54 10.08 120 75852 59767 63353283
Thyroxine free increased 13.52 10.08 10 75962 874 63412176
Somnambulism 13.50 10.08 24 75948 5519 63407531
Monoclonal gammopathy 13.46 10.08 9 75963 670 63412380
Exposure via ingestion 13.44 10.08 17 75955 2892 63410158
Hepatic steatosis 13.41 10.08 69 75903 28700 63384350
Abnormal dreams 13.39 10.08 35 75937 10481 63402569
Yellow skin 13.30 10.08 15 75957 2265 63410785
Bundle branch block 13.29 10.08 10 75962 897 63412153
Swelling face 13.24 10.08 125 75847 63350 63349700
Pre-existing condition improved 13.23 10.08 30 75942 8214 63404836
Dermatitis diaper 13.23 10.08 6 75966 206 63412844
Intentional self-injury 12.96 10.08 63 75909 25624 63387426
Hypoperfusion 12.82 10.08 12 75960 1455 63411595
Altered state of consciousness 12.81 10.08 62 75910 25168 63387882
Phonophobia 12.80 10.08 7 75965 361 63412689
Rheumatoid factor positive 12.59 10.08 55 75917 84351 63328699
Foot deformity 12.55 10.08 9 75963 27844 63385206
Osteoarthritis 12.54 10.08 65 75907 95278 63317772
Ventricular failure 12.52 10.08 7 75965 377 63412673
Wound infection 12.45 10.08 5 75967 21405 63391645
Basilar migraine 12.42 10.08 4 75968 52 63412998
Alveolar bone resorption 12.42 10.08 4 75968 52 63412998
Lung neoplasm malignant 12.41 10.08 4 75968 19629 63393421
Aspiration of gastric residual 12.37 10.08 3 75969 12 63413038
Migraine without aura 12.37 10.08 7 75965 386 63412664
Stress ulcer 12.35 10.08 4 75968 53 63412997
Treatment failure 12.28 10.08 166 75806 198877 63214173
Agranulocytosis 12.22 10.08 61 75911 25073 63387977
Disorientation 12.20 10.08 85 75887 39367 63373683
Heart rate variability increased 12.15 10.08 4 75968 56 63412994
Tonic convulsion 12.09 10.08 11 75961 1286 63411764
Bursitis 12.03 10.08 16 75956 37025 63376025
Sciatica 12.01 10.08 14 75958 34310 63378740
Urinary tract infection 11.94 10.08 234 75738 264450 63148600
Primary adrenal insufficiency 11.88 10.08 5 75967 143 63412907
Product complaint 11.83 10.08 38 75934 12771 63400279
Dyskinesia 11.76 10.08 72 75900 31930 63381120
Diabetic ketosis 11.73 10.08 6 75966 270 63412780
Tri-iodothyronine decreased 11.69 10.08 5 75967 149 63412901
Cough 11.68 10.08 264 75708 292479 63120571
Drug level increased 11.64 10.08 56 75916 22680 63390370
Weight increased 11.63 10.08 231 75741 260561 63152489
Sinus rhythm 11.58 10.08 9 75963 847 63412203
Multiple lentigines syndrome 11.57 10.08 5 75967 153 63412897
Anger 11.55 10.08 37 75935 12419 63400631
Suicidal behaviour 11.53 10.08 15 75957 2624 63410426
Tearfulness 11.50 10.08 19 75953 4120 63408930
Thyroid cancer metastatic 11.42 10.08 5 75967 158 63412892
Broad ligament tear 11.37 10.08 3 75969 18 63413032
Haemorrhagic tumour necrosis 11.37 10.08 3 75969 18 63413032
Bundle branch block right 11.36 10.08 21 75951 4977 63408073
Porphyria non-acute 11.31 10.08 6 75966 291 63412759
Blood pressure systolic increased 11.24 10.08 25 75947 47372 63365678
Oculogyric crisis 11.21 10.08 12 75960 1709 63411341
Cognitive disorder 11.19 10.08 109 75863 55706 63357344
Abnormal faeces 11.19 10.08 22 75950 5458 63407592
Septic arthritis staphylococcal 11.17 10.08 7 75965 466 63412584
Conjunctival hyperaemia 11.15 10.08 14 75958 2365 63410685
Atrophy 11.15 10.08 12 75960 1720 63411330
Dyspnoea exertional 11.14 10.08 36 75936 60266 63352784
Urine odour abnormal 11.10 10.08 24 75948 6365 63406685
Sudden infant death syndrome 11.09 10.08 6 75966 303 63412747
Nodal rhythm 11.08 10.08 12 75960 1731 63411319
Inappropriate affect 11.06 10.08 9 75963 905 63412145
Abdominal pain upper 11.06 10.08 177 75795 206267 63206783
Atrioventricular septal defect 10.96 10.08 6 75966 310 63412740
Palmar erythema 10.95 10.08 12 75960 1755 63411295
Illness 10.94 10.08 98 75874 48961 63364089
Thalamic infarction 10.92 10.08 7 75965 485 63412565
Psychotic disorder 10.85 10.08 60 75912 25652 63387398
Hand-foot-and-mouth disease 10.83 10.08 5 75967 179 63412871
Memory impairment 10.76 10.08 180 75792 104078 63308972
Bronchiectasis 10.73 10.08 3 75969 16139 63396911
Aggression 10.70 10.08 56 75916 23442 63389608
Respiratory syncytial virus infection 10.67 10.08 25 75947 6993 63406057
Hyponatraemic coma 10.63 10.08 3 75969 24 63413026
Chronotropic incompetence 10.57 10.08 4 75968 86 63412964
Muscle rigidity 10.52 10.08 34 75938 11466 63401584
Blood lactic acid increased 10.51 10.08 25 75947 7061 63405989
Restless legs syndrome 10.49 10.08 47 75925 18484 63394566
Oromandibular dystonia 10.48 10.08 7 75965 520 63412530
Obsessive-compulsive disorder 10.43 10.08 18 75954 4042 63409008
Choanal atresia 10.41 10.08 3 75969 26 63413024
Tongue pruritus 10.35 10.08 7 75965 531 63412519
Pruritus 10.27 10.08 342 75630 361111 63051939
Drug dependence 10.24 10.08 57 75915 24426 63388624
Actinic keratosis 10.15 10.08 14 75958 2590 63410460
Poor feeding infant 10.08 10.08 6 75966 364 63412686

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Product administered to patient of inappropriate age 525.90 11.06 182 40285 3109 34913355
Completed suicide 299.70 11.06 461 40006 97707 34818757
Bradycardia 264.31 11.06 378 40089 75040 34841424
Toxicity to various agents 177.70 11.06 572 39895 199790 34716674
Hepatic encephalopathy 176.61 11.06 142 40325 14543 34901921
Product use issue 172.13 11.06 282 40185 62934 34853530
Product use in unapproved indication 135.96 11.06 369 40098 117130 34799334
Intentional overdose 108.38 11.06 187 40280 43487 34872977
Nightmare 105.06 11.06 105 40362 14286 34902178
Cardiac arrest 92.74 11.06 283 40184 95876 34820588
Hepatocellular carcinoma 86.86 11.06 71 40396 7438 34909026
Sedation 86.55 11.06 114 40353 20892 34895572
Varices oesophageal 83.92 11.06 53 40414 3702 34912762
Oesophageal varices haemorrhage 82.03 11.06 49 40418 3097 34913367
Off label use 80.69 11.06 789 39678 418735 34497729
Parasomnia 78.95 11.06 26 40441 378 34916086
Hyperthyroidism 75.11 11.06 76 40391 10490 34905974
Febrile neutropenia 70.76 11.06 35 40432 136814 34779650
Pneumonia 70.62 11.06 202 40265 362425 34554039
Thyrotoxic periodic paralysis 70.51 11.06 19 40448 130 34916334
Ascites 67.02 11.06 159 40308 46412 34870052
Akathisia 64.46 11.06 62 40405 8047 34908417
Myokymia 64.31 11.06 16 40451 76 34916388
Hyperhidrosis 61.36 11.06 210 40257 75482 34840982
Infantile spitting up 60.83 11.06 14 40453 44 34916420
Poisoning deliberate 60.53 11.06 59 40408 7785 34908679
Product used for unknown indication 59.65 11.06 27 40440 956 34915508
Reversible airways obstruction 59.09 11.06 22 40445 467 34915997
Encapsulating peritoneal sclerosis 58.61 11.06 23 40444 566 34915898
Drug interaction 53.46 11.06 445 40022 225501 34690963
Overdose 51.95 11.06 226 40241 90833 34825631
Nephrolithiasis 51.94 11.06 111 40356 30222 34886242
Hepatic cirrhosis 50.82 11.06 80 40387 17234 34899230
Suicidal ideation 50.81 11.06 131 40336 40257 34876207
Cerebral artery thrombosis 49.16 11.06 22 40445 758 34915706
Areflexia 49.02 11.06 35 40432 2996 34913468
Brain scan abnormal 46.62 11.06 22 40445 858 34915606
Hepatorenal syndrome 45.94 11.06 32 40435 2634 34913830
Cardiogenic shock 45.10 11.06 97 40370 26521 34889943
Somnolence 44.28 11.06 249 40218 110867 34805597
Peripheral coldness 42.38 11.06 47 40420 7204 34909260
Hallucination, auditory 42.02 11.06 60 40407 11857 34904607
Drug ineffective for unapproved indication 40.85 11.06 87 40380 23628 34892836
Granulomatous rosacea 38.54 11.06 12 40455 144 34916320
Cardio-respiratory arrest 38.51 11.06 146 40321 55127 34861337
Sinus bradycardia 38.18 11.06 60 40407 12903 34903561
Sleep disorder 37.02 11.06 100 40367 31588 34884876
Foetal disorder 35.79 11.06 18 40449 808 34915656
Neutropenia neonatal 35.28 11.06 17 40450 695 34915769
Lethargy 34.98 11.06 116 40351 41006 34875458
Tremor 33.49 11.06 186 40281 82401 34834063
Disease progression 33.16 11.06 46 40421 108031 34808433
Respiratory arrest 32.26 11.06 88 40379 27955 34888509
Encephalopathy 32.18 11.06 102 40365 35217 34881247
Abnormal sleep-related event 31.54 11.06 14 40453 473 34915991
Psychotic disorder 31.46 11.06 80 40387 24372 34892092
Neutrophil count decreased 31.41 11.06 10 40457 51094 34865370
Platelet count decreased 31.03 11.06 57 40410 119660 34796804
Malignant neoplasm progression 30.65 11.06 34 40433 88012 34828452
Premature baby 30.38 11.06 69 40398 19564 34896900
Low birth weight baby 29.65 11.06 41 40426 7864 34908600
Pulseless electrical activity 29.48 11.06 39 40428 7172 34909292
Granulocytopenia 29.17 11.06 37 40430 6530 34909934
Photophobia 28.99 11.06 38 40429 6926 34909538
Disturbance in attention 28.44 11.06 80 40387 25865 34890599
Hepatitis C 28.26 11.06 45 40422 9785 34906679
Suicidal behaviour 28.23 11.06 19 40448 1478 34914986
Phaeochromocytoma malignant 27.76 11.06 8 40459 72 34916392
Myocardial infarction 27.67 11.06 62 40405 121023 34795441
Sepsis 26.61 11.06 101 40366 166460 34750004
Dyspnoea 26.45 11.06 294 40173 376488 34539976
White blood cell count decreased 26.03 11.06 44 40423 95401 34821063
Depression 26.03 11.06 197 40270 96901 34819563
Irritability 25.96 11.06 75 40392 24615 34891849
Portal hypertensive gastropathy 25.24 11.06 13 40454 614 34915850
Inappropriate schedule of product administration 24.38 11.06 139 40328 62157 34854307
Insomnia 24.14 11.06 204 40263 103703 34812761
Gastroenteritis eosinophilic 24.05 11.06 9 40458 194 34916270
Thyrotoxic crisis 23.92 11.06 11 40456 404 34916060
Drug withdrawal syndrome 23.57 11.06 63 40404 19771 34896693
Tardive dyskinesia 23.19 11.06 31 40436 5759 34910705
Rash 23.09 11.06 157 40310 222595 34693869
Alcohol interaction 22.64 11.06 22 40445 2891 34913573
Death 22.21 11.06 326 40141 397723 34518741
Hypoglycaemia 22.10 11.06 123 40344 54517 34861947
Interstitial lung disease 21.86 11.06 26 40441 65256 34851208
Aggression 21.65 11.06 96 40371 38868 34877596
Acute stress disorder 21.52 11.06 8 40459 169 34916295
Drug dispensed to wrong patient 21.48 11.06 11 40456 513 34915951
Hepatitis C RNA positive 21.48 11.06 8 40459 170 34916294
Hepatopulmonary syndrome 21.43 11.06 5 40462 17 34916447
Anxiety 21.42 11.06 192 40275 99236 34817228
Pain 21.34 11.06 144 40323 204531 34711933
Neuropathy peripheral 21.25 11.06 40 40427 83223 34833241
Myocardial depression 21.23 11.06 6 40461 50 34916414
Phonophobia 21.05 11.06 8 40459 180 34916284
Hallucination 20.87 11.06 116 40351 51382 34865082
Antipsychotic drug level increased 20.79 11.06 24 40443 3841 34912623
Suicide attempt 20.71 11.06 95 40372 39021 34877443
Prostate cancer 20.68 11.06 10 40457 39639 34876825
Gastric varices 20.58 11.06 11 40456 561 34915903
Alcoholism 20.47 11.06 21 40446 2944 34913520
Cardiac failure congestive 20.38 11.06 41 40426 83229 34833235
Genotype drug resistance test positive 20.33 11.06 14 40453 1131 34915333
Brain injury 20.31 11.06 30 40437 6112 34910352
Tinnitus 20.09 11.06 60 40407 20058 34896406
Joint swelling 19.90 11.06 24 40443 59866 34856598
Hypoaesthesia eye 19.72 11.06 5 40462 26 34916438
Neutropenia 19.66 11.06 104 40363 156674 34759790
Portal vein thrombosis 19.51 11.06 23 40444 3765 34912699
Agitation 19.23 11.06 123 40344 57276 34859188
Stomatitis 18.93 11.06 13 40454 42501 34873963
Sexually inappropriate behaviour 18.85 11.06 10 40457 502 34915962
Peripheral swelling 18.47 11.06 38 40429 76503 34839961
Meningitis streptococcal 18.33 11.06 5 40462 36 34916428
Chronic obstructive pulmonary disease 18.02 11.06 18 40449 48900 34867564
Drug level below therapeutic 17.95 11.06 27 40440 5588 34910876
Atrial fibrillation 17.78 11.06 77 40390 122316 34794148
Hallucination, visual 17.71 11.06 53 40414 17738 34898726
Hepatic failure 17.64 11.06 83 40384 34448 34882016
Pain in extremity 17.53 11.06 81 40386 126432 34790032
Electrocardiogram QRS complex shortened 17.34 11.06 7 40460 186 34916278
Differential white blood cell count abnormal 17.30 11.06 14 40453 1445 34915019
Phaeochromocytoma 16.99 11.06 7 40460 196 34916268
Hypotension 16.96 11.06 355 40112 221294 34695170
Mucosal inflammation 16.94 11.06 12 40455 38610 34877854
Torsade de pointes 16.74 11.06 30 40437 7179 34909285
Coma 16.62 11.06 100 40367 45578 34870886
Renal impairment 16.62 11.06 55 40412 94458 34822006
Arthralgia 16.55 11.06 122 40345 169919 34746545
Pyrexia 16.43 11.06 279 40188 332734 34583730
Atrioventricular block first degree 16.30 11.06 27 40440 6065 34910399
Withdrawal syndrome 16.28 11.06 41 40426 12414 34904050
Poor quality sleep 16.23 11.06 32 40435 8224 34908240
Social avoidant behaviour 16.19 11.06 19 40448 3095 34913369
Blunted affect 16.06 11.06 8 40459 352 34916112
Crying 15.72 11.06 26 40441 5836 34910628
Neuroleptic malignant syndrome 15.61 11.06 51 40416 17883 34898581
Pseudoporphyria 15.61 11.06 8 40459 374 34916090
Biliary anastomosis 15.59 11.06 4 40463 22 34916442
Pneumonitis 15.56 11.06 10 40457 33868 34882596
Binocular eye movement disorder 15.55 11.06 5 40462 67 34916397
Drug-induced liver injury 15.45 11.06 7 40460 28825 34887639
Suspected suicide 15.42 11.06 23 40444 4725 34911739
Rheumatoid arthritis 15.35 11.06 13 40454 38225 34878239
Peritoneal fibrosis 15.21 11.06 3 40464 3 34916461
Renal hamartoma 15.21 11.06 3 40464 3 34916461
Hepatic cancer 14.99 11.06 31 40436 8244 34908220
Disorientation 14.97 11.06 77 40390 33111 34883353
Sleep deficit 14.96 11.06 9 40458 576 34915888
Intentional product misuse 14.82 11.06 97 40370 45514 34870950
Genital swelling 14.77 11.06 6 40461 162 34916302
Alcoholic liver disease 14.64 11.06 9 40458 599 34915865
Lupus-like syndrome 14.64 11.06 17 40450 2739 34913725
Patient dissatisfaction with treatment 14.63 11.06 5 40462 82 34916382
Oesophageal variceal ligation 14.63 11.06 5 40462 82 34916382
Vital functions abnormal 14.60 11.06 7 40460 283 34916181
Restlessness 14.32 11.06 63 40404 25419 34891045
Ventricular arrhythmia 14.13 11.06 24 40443 5504 34910960
Negative thoughts 14.08 11.06 9 40458 642 34915822
Micrographia 14.00 11.06 3 40464 6 34916458
Laryngeal erythema 14.00 11.06 3 40464 6 34916458
Seizure 13.97 11.06 184 40283 104673 34811791
Ammonia increased 13.96 11.06 21 40446 4348 34912116
Coma scale abnormal 13.86 11.06 20 40447 3988 34912476
Withdrawal hypertension 13.73 11.06 6 40461 195 34916269
Intentional self-injury 13.68 11.06 41 40426 13730 34902734
Portal hypertension 13.66 11.06 20 40447 4042 34912422
Blood creatinine increased 13.64 11.06 60 40407 94916 34821548
Reflux gastritis 13.60 11.06 7 40460 330 34916134
Wrong strength 13.52 11.06 5 40462 104 34916360
Hypertrophic cardiomyopathy 13.50 11.06 11 40456 1146 34915318
Blood pressure systolic decreased 13.48 11.06 21 40446 4482 34911982
Drooling 13.38 11.06 18 40449 3364 34913100
Gastric hypomotility 13.35 11.06 5 40462 108 34916356
Pruritus 13.27 11.06 103 40364 141878 34774586
Hypocalvaria 13.08 11.06 4 40463 45 34916419
Psychomotor hyperactivity 12.91 11.06 32 40435 9590 34906874
Plasma cell myeloma 12.77 11.06 18 40449 42019 34874445
Acute kidney injury 12.71 11.06 263 40204 304725 34611739
Maternal drugs affecting foetus 12.58 11.06 19 40448 3946 34912518
Hypnagogic hallucination 12.42 11.06 4 40463 54 34916410
Infusion related reaction 12.24 11.06 27 40440 53030 34863434
Persecutory delusion 12.20 11.06 15 40452 2565 34913899
Electrocardiogram QRS complex prolonged 12.18 11.06 21 40446 4873 34911591
Growth hormone-producing pituitary tumour 12.09 11.06 4 40463 59 34916405
Haemoglobin decreased 12.06 11.06 86 40381 120686 34795778
Loss of bladder sensation 12.03 11.06 4 40463 60 34916404
Thyroxine free increased 12.02 11.06 6 40461 265 34916199
Delusion 11.97 11.06 37 40430 12598 34903866
Action tremor 11.97 11.06 4 40463 61 34916403
Hunger 11.94 11.06 12 40455 1642 34914822
Respiratory acidosis 11.70 11.06 21 40446 5029 34911435
Thrombocytopenia 11.68 11.06 120 40347 156127 34760337
Cryoglobulinaemia 11.64 11.06 7 40460 448 34916016
Stoma site haemorrhage 11.54 11.06 9 40458 881 34915583
Hyperkalaemia 11.53 11.06 127 40340 69262 34847202
Respiratory syncytial virus infection 11.45 11.06 20 40447 4689 34911775
Myelosuppression 11.43 11.06 4 40463 19261 34897203
Secondary hypogonadism 11.41 11.06 6 40461 296 34916168
Hemiplegia 11.34 11.06 25 40442 6947 34909517
Radicular pain 11.31 11.06 4 40463 73 34916391
Dysmorphism 11.29 11.06 16 40451 3140 34913324
Panic attack 11.25 11.06 30 40437 9402 34907062
Migraine 11.21 11.06 45 40422 17433 34899031
Respiratory dyskinesia 11.20 11.06 3 40464 20 34916444
Amyotrophy 11.20 11.06 7 40460 480 34915984
Constipation 11.17 11.06 103 40364 136879 34779585
Acute myocardial infarction 11.08 11.06 29 40438 53690 34862774
Intentional product use issue 11.08 11.06 34 40433 59782 34856682

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1128.96 10.07 1418 92711 244349 79405910
Bradycardia 584.51 10.07 759 93370 134798 79515461
Product administered to patient of inappropriate age 570.32 10.07 223 93906 5330 79644929
Toxicity to various agents 518.19 10.07 1369 92760 420171 79230088
Cardiac arrest 388.02 10.07 714 93415 171382 79478877
Drug ineffective for unapproved indication 350.29 10.07 364 93765 50874 79599385
Intentional overdose 317.29 10.07 499 93630 105461 79544798
Overdose 231.33 10.07 604 93525 183602 79466657
Product use in unapproved indication 229.41 10.07 733 93396 249626 79400633
Hepatic encephalopathy 210.43 10.07 196 93933 23970 79626289
Cardio-respiratory arrest 206.13 10.07 419 93710 108091 79542168
Coma 195.17 10.07 392 93737 100257 79550002
Product use issue 194.58 10.07 617 93512 209205 79441054
Drug interaction 176.06 10.07 959 93170 414224 79236035
Respiratory arrest 159.79 10.07 262 93867 57288 79592971
Hypotension 156.07 10.07 970 93159 439347 79210912
Sinus bradycardia 138.79 10.07 160 93969 25087 79625172
Poisoning deliberate 138.12 10.07 139 93990 18689 79631570
Cardiogenic shock 131.77 10.07 202 93927 41712 79608547
Nightmare 125.84 10.07 154 93975 25707 79624552
Electrocardiogram QRS complex prolonged 120.56 10.07 101 94028 10732 79639527
Suicide attempt 117.64 10.07 285 93844 82647 79567612
Hepatocellular carcinoma 112.78 10.07 90 94039 8931 79641328
Hand deformity 108.61 10.07 3 94126 103916 79546343
Electrocardiogram QT prolonged 101.89 10.07 285 93844 90101 79560158
Brain injury 99.46 10.07 93 94036 11424 79638835
Pulseless electrical activity 99.24 10.07 102 94027 14058 79636201
Wound 98.47 10.07 11 94118 116168 79534091
Hyperthyroidism 96.51 10.07 125 94004 22084 79628175
Hypoglycaemia 89.73 10.07 294 93835 101300 79548959
Varices oesophageal 88.51 10.07 66 94063 5925 79644334
Febrile neutropenia 87.62 10.07 86 94043 230913 79419346
Thyrotoxic crisis 85.95 10.07 38 94091 1246 79649013
Hyperhidrosis 85.48 10.07 380 93749 151112 79499147
Oesophageal varices haemorrhage 84.30 10.07 56 94073 4180 79646079
Joint swelling 83.78 10.07 132 93997 288514 79361745
Suicidal ideation 83.38 10.07 238 93891 76102 79574157
Pericarditis 83.17 10.07 12 94117 104224 79546035
Pneumonia 81.13 10.07 453 93676 659793 78990466
Seizure 81.02 10.07 438 93691 188396 79461863
Neovascularisation 80.62 10.07 36 94093 1209 79649050
Glossodynia 77.73 10.07 14 94115 103323 79546936
Akathisia 74.51 10.07 85 94044 13174 79637085
Systemic lupus erythematosus 74.48 10.07 25 94104 121124 79529135
Parasomnia 73.78 10.07 27 94102 534 79649725
Lower respiratory tract infection 72.21 10.07 31 94098 129189 79521070
Arthralgia 71.47 10.07 390 93739 571413 79078846
Hypoglycaemic seizure 70.43 10.07 29 94100 795 79649464
Somnolence 70.27 10.07 503 93626 238478 79411781
Thyrotoxic periodic paralysis 68.69 10.07 19 94110 142 79650117
Circulatory collapse 66.24 10.07 141 93988 37527 79612732
Off label use 65.82 10.07 1465 92664 905750 78744509
Nasopharyngitis 64.67 10.07 126 94003 253755 79396504
Myokymia 63.85 10.07 17 94112 108 79650151
Phaeochromocytoma 62.24 10.07 25 94104 642 79649617
Stomatitis 61.18 10.07 50 94079 146707 79503552
Tremor 60.85 10.07 376 93753 169707 79480552
Rheumatoid arthritis 60.78 10.07 95 94034 208375 79441884
Infection 60.66 10.07 121 94008 241591 79408668
Pain 60.35 10.07 536 93593 703266 78946993
Swelling 60.15 10.07 102 94027 216609 79433650
Synovitis 59.62 10.07 54 94075 150680 79499579
Peripheral coldness 58.90 10.07 83 94046 15887 79634372
Disease progression 58.67 10.07 79 94050 184283 79465976
Disturbance in attention 58.03 10.07 161 93968 50640 79599619
Extrapyramidal disorder 57.27 10.07 99 94030 22580 79627679
Hallucination, auditory 57.13 10.07 94 94035 20599 79629660
Pyrexia 55.95 10.07 522 93607 678187 78972072
Neuropathy peripheral 55.43 10.07 51 94078 141254 79509005
Drug withdrawal syndrome 55.42 10.07 125 94004 34593 79615666
Peripheral swelling 54.82 10.07 151 93978 269466 79380793
Suspected suicide 54.75 10.07 65 94064 10511 79639748
Electrocardiogram QRS complex shortened 53.41 10.07 23 94106 707 79649552
Helicobacter infection 53.39 10.07 9 94120 69695 79580564
Migraine 52.78 10.07 224 93905 87269 79562990
Depressed level of consciousness 49.71 10.07 236 93893 96416 79553843
Shock 48.74 10.07 137 93992 43411 79606848
Infusion related reaction 48.26 10.07 127 94002 230110 79420149
Alopecia 48.21 10.07 128 94001 231227 79419032
Product used for unknown indication 47.61 10.07 27 94102 1517 79648742
Ascites 47.57 10.07 196 93933 75366 79574893
Anuria 47.15 10.07 87 94042 20876 79629383
Encapsulating peritoneal sclerosis 46.91 10.07 22 94107 829 79649430
Hallucination 46.77 10.07 213 93916 85532 79564727
Pain in extremity 46.37 10.07 247 93882 364291 79285968
Generalised tonic-clonic seizure 46.10 10.07 135 93994 43775 79606484
Impaired healing 45.92 10.07 23 94106 87632 79562627
Arthropathy 45.87 10.07 87 94042 177024 79473235
Agitation 44.57 10.07 234 93895 99481 79550778
Depression 43.15 10.07 418 93711 216372 79433887
Muscle injury 42.69 10.07 4 94125 48557 79601702
Paradoxical drug reaction 41.97 10.07 47 94082 7138 79643121
Hepatorenal syndrome 41.96 10.07 37 94092 4212 79646047
Irritability 41.77 10.07 125 94004 41019 79609240
Rash 40.94 10.07 461 93668 577897 79072362
Somatic delusion 40.94 10.07 19 94110 699 79649560
Atrioventricular block first degree 40.38 10.07 61 94068 12430 79637829
Suicidal behaviour 39.75 10.07 32 94097 3215 79647044
Coma scale abnormal 39.52 10.07 50 94079 8628 79641631
Alcohol interaction 39.50 10.07 38 94091 4836 79645423
Intentional product use issue 37.41 10.07 77 94052 152035 79498224
Areflexia 37.22 10.07 39 94090 5495 79644764
Mobility decreased 37.21 10.07 54 94075 122121 79528138
Sleep disorder due to general medical condition, insomnia type 37.21 10.07 4 94125 43552 79606707
Sinusitis 37.16 10.07 113 94016 195388 79454871
Torsade de pointes 37.13 10.07 75 94054 19237 79631022
Interstitial lung disease 37.09 10.07 47 94082 112553 79537706
Infantile spitting up 36.85 10.07 8 94121 17 79650242
Brain scan abnormal 36.67 10.07 21 94108 1202 79649057
Myocardial depression 36.52 10.07 16 94113 513 79649746
Cerebral artery thrombosis 35.81 10.07 20 94109 1091 79649168
Atrioventricular block 35.07 10.07 61 94068 13980 79636279
Granulomatous rosacea 34.47 10.07 12 94117 204 79650055
Serotonin syndrome 34.23 10.07 124 94005 44903 79605356
Respiratory depression 33.99 10.07 90 94039 27540 79622719
Therapeutic product effect decreased 33.86 10.07 91 94038 163772 79486487
Lethargy 33.77 10.07 187 93942 81105 79569154
Herpes zoster 33.73 10.07 36 94093 93047 79557212
Metabolic acidosis 33.72 10.07 189 93940 82340 79567919
Accessory cardiac pathway 33.60 10.07 7 94122 11 79650248
Withdrawal syndrome 33.57 10.07 88 94041 26766 79623493
Loss of consciousness 33.50 10.07 324 93805 167619 79482640
Panic attack 33.02 10.07 82 94047 24134 79626125
Hypermobility syndrome 32.96 10.07 15 94114 527 79649732
Brain death 32.93 10.07 37 94092 5640 79644619
Dyspnoea 32.90 10.07 766 93363 856259 78794000
Hepatic cirrhosis 32.60 10.07 103 94026 34803 79615456
Nephrolithiasis 32.57 10.07 137 93992 53154 79597105
Galactorrhoea 32.56 10.07 30 94099 3616 79646643
Productive cough 32.19 10.07 34 94095 88297 79561962
Haemoglobin decreased 31.97 10.07 144 93985 221975 79428284
Hallucination, visual 31.88 10.07 98 94031 32631 79617628
Granulocytopenia 31.65 10.07 52 94077 11379 79638880
Malignant neoplasm progression 31.65 10.07 71 94058 135919 79514340
Myelosuppression 31.31 10.07 5 94124 40291 79609968
Gastrointestinal disorder 30.79 10.07 61 94068 122144 79528115
Abdominal discomfort 30.69 10.07 172 93957 250555 79399704
Tardive dyskinesia 30.51 10.07 49 94080 10522 79639737
Phonophobia 30.50 10.07 14 94115 502 79649757
Hepatitis C 30.04 10.07 52 94077 11873 79638386
Reversible airways obstruction 29.99 10.07 23 94106 2153 79648106
Antipsychotic drug level increased 29.83 10.07 36 94093 5921 79644338
Distributive shock 29.79 10.07 25 94104 2662 79647597
Ventricular arrhythmia 29.76 10.07 44 94085 8796 79641463
Neutropenia 29.73 10.07 208 93921 287502 79362757
Swollen tongue 29.66 10.07 114 94015 42456 79607803
Psychotic disorder 28.95 10.07 111 94018 41291 79608968
Sepsis 27.73 10.07 195 93934 269233 79381026
Sedation 27.61 10.07 128 94001 51767 79598492
Phaeochromocytoma malignant 27.61 10.07 8 94121 72 79650187
Migraine with aura 27.61 10.07 24 94105 2681 79647578
Vascular malformation 27.36 10.07 12 94117 386 79649873
Encephalopathy 27.30 10.07 154 93975 67243 79583016
Blister 27.29 10.07 63 94066 119413 79530846
Insomnia 27.05 10.07 423 93706 244747 79405512
Negative symptoms in schizophrenia 26.42 10.07 9 94120 143 79650116
Platelet count decreased 26.36 10.07 129 94000 194535 79455724
Anxiety 26.00 10.07 425 93704 248087 79402172
Thyroxine free decreased 25.93 10.07 16 94113 1051 79649208
Hepatic enzyme increased 25.91 10.07 119 94010 182491 79467768
Paranasal cyst 25.82 10.07 12 94117 443 79649816
Oedema 25.78 10.07 65 94064 119515 79530744
Vision blurred 25.57 10.07 213 93916 105685 79544574
Intentional self-injury 25.25 10.07 90 94039 32329 79617930
Vasoplegia syndrome 25.17 10.07 26 94103 3604 79646655
Discomfort 25.02 10.07 71 94058 125546 79524713
Poisoning 24.92 10.07 76 94053 25196 79625063
Agranulocytosis 24.65 10.07 112 94017 44918 79605341
Alcoholism 24.62 10.07 26 94103 3697 79646562
Neutrophil count decreased 24.45 10.07 46 94083 93913 79556346
Musculoskeletal pain 24.17 10.07 53 94076 102301 79547958
Cyanosis 24.15 10.07 75 94054 25107 79625152
Infusion site streaking 24.12 10.07 12 94117 516 79649743
Joint range of motion decreased 23.99 10.07 5 94124 33277 79616982
Gastroenteritis eosinophilic 23.60 10.07 10 94119 295 79649964
Bradycardia foetal 23.55 10.07 8 94121 126 79650133
Knee arthroplasty 23.17 10.07 11 94118 43237 79607022
Hyperreflexia 23.02 10.07 38 94091 8347 79641912
Thyrotoxic cardiomyopathy 22.97 10.07 4 94125 0 79650259
Derailment 22.90 10.07 7 94122 77 79650182
Back pain 22.85 10.07 239 93890 303941 79346318
Therapeutic product effect incomplete 22.75 10.07 88 94041 141557 79508702
Blood lactic acid increased 22.74 10.07 48 94081 12696 79637563
Hip arthroplasty 22.64 10.07 7 94122 35749 79614510
Blood pressure systolic decreased 22.48 10.07 44 94085 11032 79639227
Palpitations 22.24 10.07 238 93891 126372 79523887
Ill-defined disorder 22.21 10.07 27 94102 65848 79584411
Disorientation 21.94 10.07 138 93991 62638 79587621
Neuroleptic malignant syndrome 21.89 10.07 77 94052 27482 79622777
Depressed mood 21.81 10.07 114 94015 48366 79601893
Haematemesis 21.55 10.07 120 94009 52144 79598115
Irritable bowel syndrome 21.53 10.07 25 94104 62216 79588043
Thyroxine free increased 21.46 10.07 15 94114 1217 79649042
Chronic obstructive pulmonary disease 21.20 10.07 43 94086 85376 79564883
Cytomegalovirus infection 21.14 10.07 12 94117 42632 79607627
Portal vein thrombosis 21.07 10.07 30 94099 5797 79644462
Wheezing 21.05 10.07 69 94060 116595 79533664
Hyperammonaemic encephalopathy 20.91 10.07 27 94102 4755 79645504
Blood cholesterol increased 20.90 10.07 42 94087 83678 79566581
Abnormal sleep-related event 20.77 10.07 13 94116 876 79649383
Cerebral disorder 20.75 10.07 29 94100 5509 79644750
Bronchitis 20.45 10.07 82 94047 130562 79519697
Drug withdrawal syndrome neonatal 20.39 10.07 9 94120 294 79649965
Therapeutic product ineffective for unapproved indication 20.38 10.07 8 94121 193 79650066
Aggression 20.35 10.07 116 94013 50842 79599417
Hypothermia 20.22 10.07 66 94063 22680 79627579
Prostate cancer 20.20 10.07 7 94122 33261 79616998
Renal impairment 19.98 10.07 107 94022 157676 79492583
Pruritus 19.82 10.07 337 93792 394311 79255948
Respiratory acidosis 19.77 10.07 42 94087 11158 79639101
Mucosal inflammation 19.66 10.07 37 94092 75543 79574716
Intentional product misuse 19.66 10.07 185 93944 94980 79555279
Portal hypertensive gastropathy 19.61 10.07 15 94114 1399 79648860
Cytokine release syndrome 19.53 10.07 9 94120 35989 79614270
Cholestasis of pregnancy 19.45 10.07 13 94116 980 79649279
Gross motor delay 19.44 10.07 7 94122 132 79650127
Eosinophilic myocarditis 19.26 10.07 14 94115 1208 79649051
Muscle contractions involuntary 19.26 10.07 23 94106 3742 79646517
Porphyrins urine increased 19.17 10.07 5 94124 29 79650230
Tinnitus 19.09 10.07 103 94026 44230 79606029
Oesophageal obstruction 19.07 10.07 13 94116 1013 79649246
Mood swings 18.87 10.07 59 94070 19821 79630438
Bradypnoea 18.78 10.07 29 94100 6023 79644236
Teratogenicity 18.66 10.07 8 94121 243 79650016
Hepatitis C RNA positive 18.60 10.07 8 94121 245 79650014
Pupil fixed 18.59 10.07 22 94107 3544 79646715
Atrial fibrillation 18.55 10.07 147 93982 197739 79452520
Poor quality sleep 18.49 10.07 64 94065 22658 79627601
Lung neoplasm malignant 18.40 10.07 5 94124 27787 79622472
Drug dispensed to wrong patient 18.22 10.07 11 94118 695 79649564
Cutaneous lupus erythematosus 18.15 10.07 20 94109 2983 79647276
Acquired porphyria 18.12 10.07 5 94124 37 79650222
Sexually inappropriate behaviour 18.08 10.07 10 94119 535 79649724
Granuloma skin 18.08 10.07 36 94093 9138 79641121
Cerebellar syndrome 18.05 10.07 27 94102 5453 79644806
Dystonia 18.05 10.07 61 94068 21338 79628921
Fatigue 17.96 10.07 906 93223 928821 78721438
Confusional state 17.67 10.07 496 93633 317501 79332758
Urine amphetamine positive 17.46 10.07 6 94123 98 79650161
Porphyrins stool increased 17.36 10.07 5 94124 44 79650215
Insulin autoimmune syndrome 17.35 10.07 9 94120 423 79649836
Wrong strength 17.35 10.07 7 94122 182 79650077
Mydriasis 17.34 10.07 53 94076 17590 79632669
Mental disorder 17.24 10.07 78 94051 31224 79619035
Hypnagogic hallucination 17.17 10.07 7 94122 187 79650072
Acute stress disorder 17.11 10.07 9 94120 435 79649824
Altered state of consciousness 17.00 10.07 99 94030 43723 79606536
Hepatopulmonary syndrome 16.97 10.07 5 94124 48 79650211
Therapeutic product effective for unapproved indication 16.82 10.07 6 94123 110 79650149
Hyperprolactinaemia 16.80 10.07 24 94105 4652 79645607
Unresponsive to stimuli 16.69 10.07 118 94011 55670 79594589
Hyperthermia 16.63 10.07 53 94076 17984 79632275
Sleep paralysis 16.62 10.07 10 94119 628 79649631
Atrioventricular septal defect 16.57 10.07 6 94123 115 79650144
Pituitary apoplexy 16.54 10.07 7 94122 206 79650053
Dissociation 16.49 10.07 22 94107 3999 79646260
Drooling 16.44 10.07 27 94102 5907 79644352
Bezoar 16.42 10.07 18 94111 2670 79647589
Psychotic symptom 16.37 10.07 18 94111 2679 79647580
Grip strength decreased 16.36 10.07 3 94126 21866 79628393
Acute myeloid leukaemia 16.33 10.07 8 94121 30877 79619382
Myocardial infarction 16.24 10.07 139 93990 183990 79466269
Osteoarthritis 16.20 10.07 51 94078 87258 79563001
Feeling guilty 16.14 10.07 11 94118 857 79649402
Persecutory delusion 15.90 10.07 24 94105 4885 79645374
Exposure via transplant 15.83 10.07 4 94125 20 79650239
Somnambulism 15.81 10.07 26 94103 5695 79644564
Hepatic failure 15.79 10.07 125 94004 61087 79589172
Nodal rhythm 15.79 10.07 19 94110 3116 79647143
Oesophageal variceal ligation 15.72 10.07 6 94123 134 79650125
Heart rate decreased 15.69 10.07 139 93990 70177 79580082
Thrombosis 15.69 10.07 49 94080 84051 79566208
Pneumonitis 15.65 10.07 30 94099 60830 79589429
Medication overuse headache 15.64 10.07 11 94118 901 79649358
Blood creatinine increased 15.56 10.07 113 94016 154944 79495315
Pleural effusion 15.49 10.07 104 94025 145158 79505101
Musculoskeletal stiffness 15.49 10.07 132 93997 174876 79475383
Apraxia 15.47 10.07 18 94111 2849 79647410
Red blood cell sedimentation rate abnormal 15.42 10.07 3 94126 20960 79629299
Ventricular failure 15.39 10.07 9 94120 536 79649723
Obstructive airways disorder 15.38 10.07 9 94120 31450 79618809
Death 15.37 10.07 531 93598 565983 79084276
Basedow's disease 15.25 10.07 7 94122 251 79650008
Hyponatraemic seizure 15.24 10.07 9 94120 546 79649713
Bursitis 15.19 10.07 12 94117 35832 79614427
Distractibility 15.19 10.07 10 94119 735 79649524
Salivary hypersecretion 15.18 10.07 44 94085 14180 79636079
Perseveration 15.17 10.07 8 94121 389 79649870
Obsessive-compulsive disorder 15.13 10.07 26 94103 5901 79644358
Hypovolaemic shock 15.11 10.07 40 94089 12236 79638023
Blood prolactin increased 15.02 10.07 21 94108 3990 79646269
Headache 14.99 10.07 928 93201 652844 78997415
Maternal exposure during pregnancy 14.94 10.07 97 94032 136441 79513818
White blood cell count decreased 14.93 10.07 146 93983 188142 79462117
Jaundice 14.90 10.07 111 94018 53238 79597021
Hypertrophic cardiomyopathy 14.87 10.07 16 94113 2324 79647935
Hypoaesthesia eye 14.75 10.07 7 94122 271 79649988
Blood parathyroid hormone decreased 14.70 10.07 36 94093 10500 79639759
Chemical burn 14.69 10.07 9 94120 584 79649675
Pancytopenia 14.67 10.07 125 94004 165620 79484639
Cardiac failure congestive 14.67 10.07 103 94026 142299 79507960
Hyponatraemia 14.65 10.07 293 93836 177555 79472704
Pulmonary mass 14.64 10.07 8 94121 29026 79621233
Septic shock 14.60 10.07 85 94044 122716 79527543
Sudden infant death syndrome 14.58 10.07 7 94122 278 79649981
Muscle rigidity 14.47 10.07 54 94075 19828 79630431
Rhinorrhoea 14.42 10.07 44 94085 76030 79574229
Lip swelling 14.33 10.07 90 94039 40821 79609438
Sputum discoloured 14.23 10.07 4 94125 21739 79628520
Urinary tract infection 14.23 10.07 233 93896 274279 79375980
Laryngeal dyspnoea 14.22 10.07 7 94122 294 79649965
Pseudoporphyria 14.21 10.07 9 94120 619 79649640
Abdominal cavity drainage 14.21 10.07 10 94119 820 79649439
Narrow anterior chamber angle 14.19 10.07 6 94123 176 79650083
Yellow skin 14.10 10.07 19 94110 3486 79646773
Paraganglion neoplasm 14.01 10.07 4 94125 34 79650225
Enuresis 13.99 10.07 18 94111 3158 79647101
Peritoneal fibrosis 13.94 10.07 3 94126 6 79650253
Right aortic arch 13.94 10.07 3 94126 6 79650253
Drug intolerance 13.85 10.07 409 93720 263710 79386549
Fibromyalgia 13.84 10.07 35 94094 64305 79585954
Sinoatrial block 13.81 10.07 12 94117 1339 79648920
Hyperkalaemia 13.62 10.07 200 93929 114198 79536061
Exposure via ingestion 13.61 10.07 23 94106 5151 79645108
Palmar erythema 13.60 10.07 14 94115 1933 79648326
Food craving 13.58 10.07 13 94116 1644 79648615
Dizziness 13.53 10.07 755 93374 525686 79124573
Hallucinations, mixed 13.51 10.07 27 94102 6872 79643387
Cognitive disorder 13.49 10.07 134 93995 69792 79580467
Adrenal suppression 13.45 10.07 12 94117 1387 79648872
Alcohol use 13.41 10.07 22 94107 4809 79645450
Retroperitoneal fibrosis 13.40 10.07 9 94120 684 79649575
International normalised ratio increased 13.37 10.07 53 94076 84668 79565591
Sleep terror 13.33 10.07 21 94108 4437 79645822
Psychomotor hyperactivity 13.31 10.07 47 94082 16802 79633457
Gastrointestinal motility disorder 13.26 10.07 25 94104 6097 79644162
Blood pressure systolic increased 13.23 10.07 38 94091 66948 79583311
Blood thyroid stimulating hormone decreased 13.20 10.07 24 94105 5692 79644567
Procedural hypotension 13.15 10.07 14 94115 2009 79648250
Type 2 diabetes mellitus 13.14 10.07 30 94099 57092 79593167
Bronchiectasis 13.10 10.07 5 94124 22381 79627878
Psychomotor retardation 13.08 10.07 25 94104 6159 79644100
Oxygen saturation decreased 12.97 10.07 94 94035 128953 79521306
Hypotonia 12.97 10.07 39 94090 12831 79637428
Hypervolaemia 12.86 10.07 19 94110 42671 79607588
Gastric varices 12.86 10.07 9 94120 732 79649527
Differential white blood cell count abnormal 12.84 10.07 14 94115 2063 79648196
Hyperbilirubinaemia 12.69 10.07 60 94069 24458 79625801
Meconium in amniotic fluid 12.69 10.07 5 94124 122 79650137
Withdrawal hypertension 12.61 10.07 7 94122 377 79649882
Chromaturia 12.60 10.07 62 94067 25684 79624575
Drug level increased 12.53 10.07 85 94044 39566 79610693
Bone marrow failure 12.45 10.07 26 94103 51081 79599178
Aspiration of gastric residual 12.42 10.07 3 94126 12 79650247
Myoclonus 12.41 10.07 65 94064 27595 79622664
Joint effusion 12.39 10.07 3 94126 18011 79632248
Memory impairment 12.39 10.07 193 93936 111541 79538718
Agoraphobia 12.38 10.07 8 94121 570 79649689
Contusion 12.38 10.07 114 94015 148662 79501597
Essential tremor 12.37 10.07 12 94117 1543 79648716
Lung disorder 12.33 10.07 51 94078 80506 79569753
Affective disorder 12.23 10.07 29 94100 8290 79641969
Genotype drug resistance test positive 12.14 10.07 11 94118 1297 79648962
Heart rate variability increased 12.14 10.07 4 94125 57 79650202
Transfusion 12.10 10.07 5 94124 21325 79628934
Anaemia 12.08 10.07 417 93712 444598 79205661
Cough 12.08 10.07 335 93794 366454 79283805
Panniculitis 12.01 10.07 37 94092 12334 79637925
Transplant rejection 11.96 10.07 4 94125 19433 79630826
Bleeding varicose vein 11.88 10.07 8 94121 611 79649648
Pneumonia bacterial 11.86 10.07 4 94125 19327 79630932
Drug tolerance decreased 11.84 10.07 38 94091 12940 79637319
Dysarthria 11.81 10.07 127 94002 67495 79582764
Blood pressure diastolic abnormal 11.73 10.07 4 94125 19198 79631061
Basilar migraine 11.66 10.07 4 94125 65 79650194
Growth hormone-producing pituitary tumour 11.66 10.07 4 94125 65 79650194
Ear discomfort 11.63 10.07 29 94100 8554 79641705
Breath holding 11.60 10.07 4 94125 66 79650193
Ventricular tachycardia 11.57 10.07 87 94042 41848 79608411
Gynaecomastia 11.53 10.07 27 94102 7654 79642605
Negative thoughts 11.51 10.07 11 94118 1388 79648871
Asthma 11.46 10.07 103 94026 134992 79515267
Mastoiditis 11.45 10.07 12 94117 1692 79648567
Bacterial infection 11.44 10.07 12 94117 31268 79618991
COVID-19 11.38 10.07 125 94004 157549 79492710
Full blood count abnormal 11.26 10.07 19 94110 40455 79609804
Goitre 11.23 10.07 22 94107 5517 79644742
Facial paralysis 11.23 10.07 52 94077 21020 79629239
Oral discomfort 11.21 10.07 31 94098 9729 79640530
Cytopenia 11.21 10.07 5 94124 20378 79629881
Neoplasm progression 11.21 10.07 28 94101 51654 79598605
Alveolar bone resorption 11.18 10.07 4 94125 74 79650185
Clostridium difficile colitis 11.13 10.07 13 94116 32270 79617989
Right ventricular failure 11.10 10.07 7 94122 23490 79626769
Meningitis streptococcal 11.06 10.07 5 94124 173 79650086
Cerebral vasoconstriction 11.05 10.07 11 94118 1459 79648800
Blood pressure immeasurable 11.00 10.07 13 94116 2091 79648168
Apathy 10.95 10.07 37 94092 12940 79637319
Abnormal behaviour 10.87 10.07 77 94052 36344 79613915
Patient dissatisfaction with treatment 10.85 10.07 5 94124 181 79650078
Respiratory rate decreased 10.85 10.07 21 94108 5222 79645037
Vertigo 10.82 10.07 127 94002 68955 79581304
Genital swelling 10.80 10.07 6 94123 324 79649935
Antipsychotic drug level decreased 10.79 10.07 10 94119 1214 79649045
Subdural hygroma 10.79 10.07 7 94122 502 79649757
Thyroid cancer metastatic 10.77 10.07 5 94124 184 79650075
Injection site pruritus 10.74 10.07 21 94108 42262 79607997
Abnormal faeces 10.70 10.07 26 94103 7545 79642714
Gastric hypomotility 10.70 10.07 5 94124 187 79650072
Brugada syndrome 10.69 10.07 10 94119 1228 79649031
Violence-related symptom 10.68 10.07 8 94121 723 79649536
Blood growth hormone increased 10.63 10.07 8 94121 728 79649531
Device related infection 10.59 10.07 15 94114 34279 79615980
Monocyte count abnormal 10.57 10.07 5 94124 192 79650067
Multiple lentigines syndrome 10.50 10.07 5 94124 195 79650064
Electrocardiogram T wave inversion 10.49 10.07 21 94108 5351 79644908
Urine odour abnormal 10.47 10.07 23 94106 6250 79644009
Tonic convulsion 10.44 10.07 13 94116 2207 79648052
Cardiotoxicity 10.42 10.07 35 94094 12204 79638055
Tinea versicolour 10.39 10.07 6 94123 349 79649910
Hypersensitivity 10.39 10.07 233 93896 262006 79388253
Bundle branch block 10.27 10.07 11 94118 1589 79648670
Haemorrhagic tumour necrosis 10.26 10.07 3 94126 28 79650231
Wound infection 10.21 10.07 8 94121 23983 79626276
Nervousness 10.18 10.07 71 94058 33344 79616915
Secondary hypogonadism 10.17 10.07 6 94123 363 79649896
Loss of bladder sensation 10.17 10.07 4 94125 97 79650162
Sprue-like enteropathy 10.16 10.07 10 94119 1308 79648951
Low cardiac output syndrome 10.12 10.07 9 94120 1036 79649223
Primary adrenal insufficiency 10.11 10.07 5 94124 212 79650047
Respiratory tract infection 10.08 10.07 27 94102 48662 79601597
Tongue pruritus 10.07 10.07 7 94122 563 79649696

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C07AA05 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Beta blocking agents, non-selective
ATC C07BA05 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND THIAZIDES
Beta blocking agents, non-selective, and thiazides
ATC C07FX01 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
FDA MoA N0000000161 Adrenergic beta-Antagonists
FDA EPC N0000175556 beta-Adrenergic Blocker
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014665 Vasodilator Agents
CHEBI has role CHEBI:35474 anti-anxiety agents
CHEBI has role CHEBI:35530 beta-adrenergic blockers
CHEBI has role CHEBI:35620 vasodilator agents
CHEBI has role CHEBI:35674 antihypertensive drugs
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:38070 antiarrhythmic agent
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:85234 human blood serum metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Supraventricular tachycardia indication 6456007
Hypertensive disorder indication 38341003 DOID:10763
Atrial fibrillation indication 49436004 DOID:0060224
Angina pectoris indication 194828000
Hypertrophic cardiomyopathy indication 233873004 DOID:11984
Idiopathic hypertrophic subaortic stenosis indication 360465008
Hemangioma indication 400210000 DOID:255
Essential tremor indication 609558009 DOID:4990
Life-Threatening Ventricular Tachycardia indication
Ulcerated haemangioma indication
Proliferating infantile haemangioma requiring systemic therapy indication
Life or functionthreatening haemangioma indication
Haemangioma with a risk of permanent scars or disfigurement indication
Arrhythmias During Surgery indication
Pheochromocytoma Adjunct Therapy indication
Migraine Prevention indication
Myocardial Reinfarction Prevention indication
Thyrotoxicosis off-label use 90739004 DOID:7997
Mitral valve prolapse off-label use 409712001
Prevention of Congenital Long QT Syndrome associated Ventricular Arrhythmia off-label use
Prevention of Post Cardio-Thoracic Surgery Atrial Fibrillation off-label use
Prevention of Bleeding Esophageal Varices off-label use
Anuria contraindication 2472002 DOID:2983
Bronchospasm contraindication 4386001
Hypercholesterolemia contraindication 13644009
Secondary angle-closure glaucoma contraindication 21571006
Complete atrioventricular block contraindication 27885002
Hypovolemia contraindication 28560003
Dehydration contraindication 34095006
Depressive disorder contraindication 35489007
Hyperuricemia contraindication 35885006 DOID:1920
Sick sinus syndrome contraindication 36083008 DOID:13884
Hypokalemia contraindication 43339004
Sinus bradycardia contraindication 49710005
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Chronic bronchitis contraindication 63480004 DOID:6132
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Wolff-Parkinson-White pattern contraindication 74390002 DOID:384
Pulmonary emphysema contraindication 87433001
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Disorder of muscle contraindication 129565002 DOID:423
Hypomagnesemia contraindication 190855004
Second degree atrioventricular block contraindication 195042002
Decompensated cardiac failure contraindication 195111005
Acute pancreatitis contraindication 197456007 DOID:2913
Disease of liver contraindication 235856003 DOID:409
Hypoglycemic disorder contraindication 237630007
Raynaud's phenomenon contraindication 266261006
Neonatal hyperbilirubinemia contraindication 281610001
Pregnancy, function contraindication 289908002
Severe chronic obstructive pulmonary disease contraindication 313299006
Azotemia contraindication 445009001
Smokes tobacco daily contraindication 449868002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.19 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
4.28MG/ML HEMANGEOL PIERRE FABRE DERMA N205410 March 14, 2014 RX SOLUTION ORAL 8338489 Oct. 16, 2028 METHOD TO TREAT HEMANGIOMA.
4.28MG/ML HEMANGEOL PIERRE FABRE DERMA N205410 March 14, 2014 RX SOLUTION ORAL 8987262 Oct. 16, 2028 METHOD TO TREAT INFANTILE HEMANGIOMA

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR ANTAGONIST Ki 8.71 WOMBAT-PK DRUG LABEL
Beta-2 adrenergic receptor GPCR ANTAGONIST Ki 8.25 WOMBAT-PK DRUG LABEL
Multidrug resistance protein 1 Transporter Ki 4.32 CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 6.70 DRUG MATRIX
5-hydroxytryptamine receptor 1A GPCR Ki 6.91 PDSP
5-hydroxytryptamine receptor 2A GPCR Ki 5.38 PDSP
5-hydroxytryptamine receptor 2B GPCR Ki 6.66 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 5.92 DRUG MATRIX
5-hydroxytryptamine receptor 6 GPCR Ki 5.85 DRUG MATRIX
Histamine H1 receptor GPCR Ki 4.70 WOMBAT-PK
Beta-3 adrenergic receptor GPCR ANTAGONIST Ki 6.22 WOMBAT-PK
5-hydroxytryptamine receptor 1B GPCR Ki 6.20 PDSP
5-hydroxytryptamine receptor 1D GPCR Ki 5.35 PDSP
Cytochrome P450 2D6 Enzyme IC50 5.70 DRUG MATRIX
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel Ki 4.32 WOMBAT-PK
Cytochrome P450 1A2 Enzyme IC50 5.40 DRUG MATRIX
Solute carrier family 22 member 1 Transporter IC50 4.20 CHEMBL
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Ion channel IC50 4.30 WOMBAT-PK
Nuclear receptor subfamily 2 group E member 1 Nuclear hormone receptor Kd 6.30 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 5.92 DRUG MATRIX
5-hydroxytryptamine receptor 1B GPCR Ki 7.30 CHEMBL
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 5.67 DRUG MATRIX
D(2) dopamine receptor GPCR Ki 4.89 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 7.05 CHEMBL
Beta-2 adrenergic receptor GPCR Kd 9.01 CHEMBL
Beta-2 adrenergic receptor GPCR Kd 9.05 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 8.52 CHEMBL
Beta-2 adrenergic receptor GPCR IC50 7.77 CHEMBL
Beta-1 adrenergic receptor GPCR Kd 8.76 CHEMBL
Adrenergic receptor beta GPCR Ki 8.62 CHEMBL
Beta-3 adrenergic receptor GPCR ANTAGONIST Ki 6.60 IUPHAR
Beta-1 adrenergic receptor GPCR Ki 8.62 CHEMBL

External reference:

IDSource
4019916 VUID
N0000148001 NUI
D00483 KEGG_DRUG
318-98-9 SECONDARY_CAS_RN
4017831 VANDF
4019916 VANDF
C0033497 UMLSCUI
CHEBI:8499 CHEBI
CHEMBL27 ChEMBL_ID
DB00571 DRUGBANK_ID
CHEMBL1671 ChEMBL_ID
D011433 MESH_DESCRIPTOR_UI
4946 PUBCHEM_CID
564 IUPHAR_LIGAND_ID
1940 INN_ID
9Y8NXQ24VQ UNII
82084 RXNORM
2240 MMSL
5375 MMSL
d00032 MMSL
001850 NDDF
004740 NDDF
372772003 SNOMEDCT_US
55745002 SNOMEDCT_US
65088001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-3727 SOLUTION 20 mg ORAL ANDA 11 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-3727 SOLUTION 20 mg ORAL ANDA 11 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-3730 SOLUTION 40 mg ORAL ANDA 11 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-3730 SOLUTION 40 mg ORAL ANDA 11 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0115-1659 TABLET 10 mg ORAL ANDA 21 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0115-1660 TABLET 20 mg ORAL ANDA 21 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0115-1661 TABLET 40 mg ORAL ANDA 21 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0115-1662 TABLET 80 mg ORAL ANDA 21 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0115-1693 TABLET 60 mg ORAL ANDA 19 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-0908 SOLUTION 20 mg ORAL ANDA 11 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-0908 SOLUTION 20 mg ORAL ANDA 11 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9872 INJECTION 1 mg INTRAVENOUS ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9872 INJECTION 1 mg INTRAVENOUS ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0228-2778 CAPSULE, EXTENDED RELEASE 60 mg ORAL ANDA 20 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0228-2779 CAPSULE, EXTENDED RELEASE 80 mg ORAL ANDA 20 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0228-2780 CAPSULE, EXTENDED RELEASE 120 mg ORAL ANDA 20 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0228-2781 CAPSULE, EXTENDED RELEASE 160 mg ORAL ANDA 20 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-0182 TABLET 10 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-0182 TABLET 10 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-0183 TABLET 20 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-0183 TABLET 20 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-0184 TABLET 40 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-0184 TABLET 40 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-0185 TABLET 80 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-0185 TABLET 80 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-0187 TABLET 60 mg ORAL ANDA 23 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-0187 TABLET 60 mg ORAL ANDA 23 sections
PROPRANOLOL HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9944 INJECTION 1 mg INTRAVENOUS ANDA 12 sections
PROPRANOLOL HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9944 INJECTION 1 mg INTRAVENOUS ANDA 12 sections
Propranolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-4116 CAPSULE, EXTENDED RELEASE 60 mg ORAL ANDA 23 sections