propofol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	2302	2078-54-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: propofol ampofol diprivan disoprofol pofol	An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS. Molecular weight: 178.28 Formula: C12H18O CLOGP: 3.93 LIPINSKI: 0 HAC: 1 HDO: 1 TPSA: 20.23 ALOGS: -3.05 ROTB: 2 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

propofol
ampofol
diprivan
disoprofol
pofol

An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.

Molecular weight: 178.28
Formula: C12H18O
CLOGP: 3.93
LIPINSKI: 0
HAC: 1
HDO: 1
TPSA: 20.23
ALOGS: -3.05
ROTB: 2

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.16 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0.50 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	14.02 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution)	4.70 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	36 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.02 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	3.20 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Oct. 2, 1989	FDA	FRESENIUS KABI USA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Anaphylactic shock	2837.85	15.90	910	39973	22723	63425416
Anaphylactic reaction	1182.70	15.90	655	40228	65445	63382694
Hypotension	964.59	15.90	1023	39860	271581	63176558
Cardiac arrest	853.47	15.90	602	40281	91943	63356196
Bronchospasm	773.89	15.90	322	40561	16958	63431181
Propofol infusion syndrome	753.90	15.90	165	40718	818	63447321
Serotonin syndrome	465.42	15.90	267	40616	28415	63419724
Tachycardia	418.73	15.90	445	40438	117711	63330428
Circulatory collapse	404.18	15.90	222	40661	21716	63426423
Bradycardia	401.88	15.90	351	40532	72876	63375263
Stress cardiomyopathy	385.91	15.90	165	40718	9285	63438854
Delayed recovery from anaesthesia	383.81	15.90	91	40792	680	63447459
Hyperthermia malignant	330.95	15.90	82	40801	752	63447387
Fatigue	325.82	15.90	86	40797	887942	62560197
Respiratory depression	324.26	15.90	164	40719	13551	63434588
Drug interaction	298.37	15.90	531	40352	228600	63219539
Status epilepticus	291.21	15.90	158	40725	15075	63433064
Arthralgia	270.83	15.90	27	40856	569683	62878456
Multiple organ dysfunction syndrome	265.91	15.90	249	40634	56503	63391636
Ventricular tachycardia	264.03	15.90	163	40720	19816	63428323
Neuromuscular block prolonged	244.07	15.90	59	40824	483	63447656
Ventricular fibrillation	226.57	15.90	123	40760	11744	63436395
Oxygen saturation decreased	224.73	15.90	281	40602	88304	63359835
Diarrhoea	220.51	15.90	93	40790	715273	62732866
Shock	218.88	15.90	154	40729	23309	63424830
Metabolic acidosis	215.44	15.90	200	40683	44869	63403270
Haemodynamic instability	211.70	15.90	108	40775	9082	63439057
Myoglobin urine present	209.09	15.90	56	40827	716	63447423
Blood pressure decreased	195.63	15.90	225	40658	64797	63383342
Joint swelling	191.66	15.90	4	40879	327662	63120477
Procedural hypotension	185.13	15.90	56	40827	1134	63447005
Blood creatine phosphokinase increased	181.25	15.90	153	40730	30277	63417862
Apnoea	181.08	15.90	93	40790	7929	63440210
Alopecia	180.23	15.90	9	40874	337527	63110612
Pulseless electrical activity	177.94	15.90	90	40793	7431	63440708
Rhabdomyolysis	176.05	15.90	177	40706	43774	63404365
Drug intolerance	175.81	15.90	5	40878	308656	63139483
Unwanted awareness during anaesthesia	174.01	15.90	41	40842	297	63447842
Anaesthetic complication	169.14	15.90	59	40824	1901	63446238
Myoclonus	157.00	15.90	108	40775	15760	63432379
Diabetes insipidus	155.90	15.90	60	40823	2565	63445574
Fall	155.12	15.90	32	40851	392302	63055837
Dystonia	153.36	15.90	101	40782	13718	63434421
Type I hypersensitivity	149.26	15.90	60	40823	2882	63445257
Abdominal discomfort	147.61	15.90	17	40866	320868	63127271
Headache	145.73	15.90	117	40766	633124	62815015
Hypoxia	145.72	15.90	186	40697	59606	63388533
Electrocardiogram ST segment elevation	145.37	15.90	64	40819	3863	63444276
Pain	142.31	15.90	161	40722	740467	62707672
Labile blood pressure	139.71	15.90	50	40833	1739	63446400
Post procedural complication	138.54	15.90	103	40780	16971	63431168
Anaphylactoid shock	138.07	15.90	34	40849	303	63447836
Generalised tonic-clonic seizure	133.31	15.90	126	40757	28890	63419249
Cardio-respiratory arrest	132.88	15.90	178	40705	59781	63388358
Nasopharyngitis	131.87	15.90	8	40875	254249	63193890
Rheumatoid arthritis	128.64	15.90	9	40874	253810	63194329
Amylase increased	127.35	15.90	68	40815	6277	63441862
Respiratory acidosis	126.50	15.90	69	40814	6646	63441493
Arthropathy	126.09	15.90	6	40877	234786	63213353
Torsade de pointes	123.03	15.90	87	40796	13264	63434875
Toxic encephalopathy	122.27	15.90	67	40816	6512	63441627
Airway complication of anaesthesia	120.68	15.90	28	40855	188	63447951
Malaise	120.12	15.90	59	40824	415895	63032244
Procedural complication	119.71	15.90	62	40821	5377	63442762
Sinusitis	117.93	15.90	7	40876	226646	63221493
Unresponsive to stimuli	117.10	15.90	126	40757	33690	63414449
Anticholinergic syndrome	115.41	15.90	47	40836	2335	63445804
Product dose omission issue	113.99	15.90	10	40873	234303	63213836
Systemic lupus erythematosus	113.27	15.90	5	40878	208913	63239226
Peripheral swelling	112.99	15.90	18	40865	265924	63182215
Multiple-drug resistance	111.11	15.90	58	40825	5112	63443027
Laryngospasm	110.96	15.90	49	40834	2979	63445160
Anaphylactoid reaction	110.43	15.90	52	40831	3671	63444468
Pain in extremity	108.54	15.90	39	40844	331447	63116692
Kounis syndrome	107.96	15.90	41	40842	1689	63446450
Dizziness	105.72	15.90	74	40809	429851	63018288
Weight increased	105.65	15.90	20	40863	260772	63187367
Clonus	105.36	15.90	54	40829	4582	63443557
Respiratory failure	104.93	15.90	214	40669	101644	63346495
Tryptase increased	104.75	15.90	28	40855	355	63447784
Hypoventilation	104.08	15.90	54	40829	4700	63443439
Cardiogenic shock	102.34	15.90	88	40795	17844	63430295
Encephalopathy	101.83	15.90	125	40758	38495	63409644
Arteriospasm coronary	101.28	15.90	50	40833	3918	63444221
Infusion related reaction	101.23	15.90	18	40865	245503	63202636
Premature delivery	99.91	15.90	110	40773	30171	63417968
Swelling	99.79	15.90	27	40856	275351	63172788
Troponin increased	98.03	15.90	68	40815	10053	63438086
Seizure	96.80	15.90	243	40640	132391	63315748
Allergy test negative	95.94	15.90	23	40860	181	63447958
Acute generalised exanthematous pustulosis	94.65	15.90	69	40814	11030	63437109
Electrocardiogram QT prolonged	94.50	15.90	151	40732	59379	63388760
Nausea	94.11	15.90	263	40620	854208	62593931
Mitochondrial DNA mutation	92.87	15.90	26	40857	396	63447743
PCO2 increased	90.65	15.90	33	40850	1206	63446933
Mydriasis	90.06	15.90	69	40814	11887	63436252
Respiratory arrest	89.87	15.90	108	40775	32537	63415602
Weight decreased	89.84	15.90	33	40850	276765	63171374
Contraindicated product administered	89.62	15.90	16	40867	217632	63230507
Intestinal ischaemia	88.78	15.90	57	40826	7411	63440728
Ventricular hypokinesia	88.25	15.90	48	40835	4596	63443543
Renal ischaemia	86.64	15.90	27	40856	606	63447533
Intra-abdominal pressure increased	86.44	15.90	22	40861	227	63447912
Product contamination	85.81	15.90	28	40855	732	63447407
Pruritus	85.19	15.90	65	40818	361388	63086751
Brain oedema	83.73	15.90	71	40812	14124	63434015
Opisthotonus	83.23	15.90	23	40860	333	63447806
Agitation	82.02	15.90	142	40741	59615	63388524
Exposure during pregnancy	81.88	15.90	253	40630	155294	63292845
Blood lactate dehydrogenase increased	81.55	15.90	87	40796	23029	63425110
Dyspnoea	80.78	15.90	193	40690	661120	62787019
Blood gases abnormal	80.52	15.90	27	40856	770	63447369
Anaesthetic complication pulmonary	79.94	15.90	16	40867	46	63448093
Discomfort	79.10	15.90	8	40875	167366	63280773
Posterior reversible encephalopathy syndrome	79.04	15.90	75	40808	17270	63430869
Pulmonary oedema	77.42	15.90	132	40751	54741	63393398
Musculoskeletal stiffness	77.25	15.90	13	40870	184605	63263534
Stridor	77.21	15.90	40	40843	3470	63444669
Hepatic ischaemia	77.15	15.90	25	40858	639	63447500
Disseminated intravascular coagulation	76.76	15.90	77	40806	18974	63429165
Wound	76.64	15.90	8	40875	163255	63284884
Transmission of an infectious agent via product	76.08	15.90	18	40865	133	63448006
Anaesthetic complication neurological	75.53	15.90	20	40863	244	63447895
Drug ineffective for unapproved indication	75.24	15.90	101	40782	33962	63414177
Insomnia	74.46	15.90	23	40860	215229	63232910
Oliguria	74.04	15.90	55	40828	9046	63439093
Laryngeal oedema	73.86	15.90	46	40837	5672	63442467
Vasoplegia syndrome	73.77	15.90	31	40852	1668	63446471
Lower respiratory tract infection	72.24	15.90	3	40880	132304	63315835
Partial seizures	70.46	15.90	45	40838	5797	63442342
Decreased appetite	70.29	15.90	37	40846	251015	63197124
Coagulopathy	70.15	15.90	76	40807	20468	63427671
Acute hepatic failure	70.05	15.90	72	40811	18255	63429884
Acute respiratory distress syndrome	69.98	15.90	81	40802	23453	63424686
Contusion	68.79	15.90	8	40875	150036	63298103
CSF oligoclonal band present	67.31	15.90	20	40863	380	63447759
Blood pH decreased	67.22	15.90	33	40850	2554	63445585
PO2 increased	66.51	15.90	24	40859	855	63447284
Sinus tachycardia	66.32	15.90	80	40803	24188	63423951
Constipation	66.22	15.90	31	40852	224912	63223227
Carcinoid crisis	65.96	15.90	18	40865	248	63447891
Pneumatosis	65.65	15.90	20	40863	415	63447724
Myoclonic epilepsy	65.09	15.90	26	40857	1228	63446911
Hepatorenal syndrome	63.57	15.90	29	40854	1903	63446236
Oculogyric crisis	63.54	15.90	28	40855	1693	63446446
Hyperreflexia	62.52	15.90	42	40841	5892	63442247
Electrocardiogram QRS complex prolonged	62.49	15.90	42	40841	5896	63442243
Renal impairment	62.46	15.90	160	40723	88195	63359944
Alanine aminotransferase increased	62.39	15.90	177	40706	103593	63344546
Stomatitis	62.11	15.90	8	40875	138717	63309422
Arthritis	62.07	15.90	3	40880	115918	63332221
Angioedema	61.96	15.90	111	40772	47854	63400285
Erythema	61.54	15.90	250	40633	175501	63272638
Hepatic failure	61.52	15.90	94	40789	35562	63412577
Endotracheal intubation complication	60.90	15.90	19	40864	428	63447711
Atrioventricular block complete	60.79	15.90	47	40836	8204	63439935
Necrosis ischaemic	59.56	15.90	22	40861	838	63447301
Neuromuscular blockade	59.42	15.90	17	40866	281	63447858
Septic shock	59.35	15.90	132	40751	66497	63381642
Coma	59.01	15.90	129	40754	64235	63383904
Ventricular extrasystoles	58.01	15.90	53	40830	11634	63436505
Gene mutation	57.98	15.90	26	40857	1639	63446500
Oxygen saturation abnormal	57.58	15.90	33	40850	3496	63444643
Dyskinesia	57.53	15.90	86	40797	31916	63416223
Maternal exposure during delivery	57.31	15.90	25	40858	1475	63446664
Muscle rigidity	56.78	15.90	52	40831	11448	63436691
Postoperative delirium	56.46	15.90	13	40870	84	63448055
Bronchitis	56.42	15.90	7	40876	124928	63323211
Blood lactic acid increased	55.81	15.90	42	40841	7044	63441095
Acute pulmonary oedema	54.79	15.90	44	40839	8114	63440025
Hepatitis acute	54.58	15.90	46	40837	9074	63439065
End-tidal CO2 decreased	54.33	15.90	10	40873	15	63448124
Hepatocellular injury	54.18	15.90	77	40806	27304	63420835
Hepatic enzyme increased	53.48	15.90	32	40851	202296	63245843
Pleocytosis	52.64	15.90	20	40863	825	63447314
Drug reaction with eosinophilia and systemic symptoms	52.55	15.90	85	40798	33751	63414388
Inappropriate schedule of product administration	51.73	15.90	4	40879	103961	63344178
Gastrointestinal disorder	51.15	15.90	11	40872	131228	63316911
Foetal death	51.02	15.90	48	40835	10932	63437207
Infection	50.46	15.90	44	40839	229129	63219010
Renal failure	49.94	15.90	178	40705	117474	63330665
Pneumonia	49.75	15.90	141	40742	456626	62991513
Acidosis hyperchloraemic	49.19	15.90	16	40867	414	63447725
Asthenia	49.08	15.90	109	40774	383495	63064644
Upper airway obstruction	48.75	15.90	18	40865	685	63447454
Gait disturbance	48.37	15.90	29	40854	183149	63264990
Hypovolaemia	48.34	15.90	46	40837	10627	63437512
Toxic epidermal necrolysis	48.30	15.90	70	40813	25264	63422875
Therapeutic product effect prolonged	47.82	15.90	15	40868	344	63447795
Post procedural haemorrhage	47.31	15.90	40	40843	7924	63440215
Influenza	46.94	15.90	7	40876	108715	63339424
Urinary tract infection	46.91	15.90	61	40822	264623	63183516
Back pain	46.69	15.90	61	40822	264084	63184055
Blood bicarbonate decreased	46.65	15.90	27	40856	2914	63445225
Fear	46.43	15.90	54	40829	15712	63432427
Unmasking of previously unidentified disease	46.40	15.90	19	40864	957	63447182
Blood potassium increased	46.22	15.90	58	40825	18251	63429888
Altered state of consciousness	45.63	15.90	68	40815	25162	63422977
Hypercapnia	44.58	15.90	33	40850	5398	63442741
Muscle relaxant therapy	43.86	15.90	12	40871	167	63447972
Shock haemorrhagic	43.59	15.90	42	40841	9853	63438286
Chest pain	43.40	15.90	45	40838	215914	63232225
Phrenic nerve paralysis	42.78	15.90	12	40871	184	63447955
Arrhythmia	42.67	15.90	83	40800	38057	63410082
Acute kidney injury	42.63	15.90	303	40580	263112	63185027
Hypertriglyceridaemia	42.55	15.90	34	40849	6225	63441914
Mental status changes postoperative	42.54	15.90	12	40871	188	63447951
Cardiovascular insufficiency	42.34	15.90	20	40863	1421	63446718
Hyperlactacidaemia	42.14	15.90	25	40858	2824	63445315
Atrioventricular block second degree	41.95	15.90	28	40855	3886	63444253
Electrocardiogram ST segment depression	41.92	15.90	25	40858	2852	63445287
Delirium	41.53	15.90	97	40786	50444	63397695
Psoriasis	41.47	15.90	4	40879	86953	63361186
Product contamination microbial	41.47	15.90	12	40871	207	63447932
Depressed level of consciousness	41.38	15.90	110	40773	61968	63386171
Suspected product quality issue	41.15	15.90	12	40871	213	63447926
Electroencephalogram abnormal	41.12	15.90	27	40856	3645	63444494
Local anaesthetic systemic toxicity	41.04	15.90	17	40866	882	63447257
Pulse absent	40.44	15.90	31	40852	5343	63442796
Abdominal pain upper	40.38	15.90	44	40839	206400	63241739
Tracheal deviation	40.35	15.90	11	40872	151	63447988
Loss of personal independence in daily activities	40.35	15.90	7	40876	97283	63350856
Hepatitis	40.22	15.90	83	40800	39705	63408434
Confusion postoperative	40.09	15.90	12	40871	234	63447905
Perforation	39.69	15.90	18	40865	1165	63446974
Injection site pain	39.56	15.90	17	40866	129783	63318356
Premature baby	39.10	15.90	57	40826	20678	63427461
Toxicity to various agents	38.61	15.90	282	40601	246968	63201171
Intentional product use issue	38.58	15.90	17	40866	127875	63320264
Malignant neoplasm progression	38.58	15.90	4	40879	82117	63366022
Procedural nausea	38.50	15.90	16	40867	837	63447302
Hepatorenal failure	38.15	15.90	15	40868	679	63447460
Brain death	38.01	15.90	25	40858	3385	63444754
Airway peak pressure increased	37.94	15.90	12	40871	283	63447856
Left ventricle outflow tract obstruction	37.90	15.90	12	40871	284	63447855
Disease progression	37.54	15.90	16	40867	122742	63325397
Change in seizure presentation	37.53	15.90	13	40870	410	63447729
Skin test positive	37.38	15.90	15	40868	717	63447422
Impaired healing	37.19	15.90	10	40873	102532	63345607
Recurrence of neuromuscular blockade	36.90	15.90	10	40873	134	63448005
Left ventricular dysfunction	36.88	15.90	42	40841	11946	63436193
Neutropenia	36.84	15.90	35	40848	174970	63273169
Wrong product administered	36.80	15.90	31	40852	6110	63442029
Neuroleptic malignant syndrome	36.69	15.90	42	40841	12014	63436125
Cardiac output decreased	36.49	15.90	16	40867	956	63447183
Herpes zoster	36.32	15.90	5	40878	82457	63365682
Paralysis	36.23	15.90	38	40845	9862	63438277
Neuropathy peripheral	36.08	15.90	14	40869	113653	63334486
Hepatic cytolysis	36.05	15.90	47	40836	15360	63432779
Irregular breathing	35.99	15.90	12	40871	336	63447803
Renal injury	35.92	15.90	37	40846	9402	63438737
Ill-defined disorder	35.90	15.90	5	40878	81750	63366389
Ultrasound ovary abnormal	35.80	15.90	9	40874	88	63448051
Feeling abnormal	35.77	15.90	26	40857	148366	63299773
Intensive care unit acquired weakness	35.71	15.90	15	40868	806	63447333
Procedural haemorrhage	35.67	15.90	22	40861	2666	63445473
Cyanosis	35.55	15.90	49	40834	16886	63431253
Phaeochromocytoma crisis	35.50	15.90	11	40872	242	63447897
Lactic acidosis	35.38	15.90	77	40806	38210	63409929
Rash maculo-papular	35.18	15.90	69	40814	31827	63416312
Stevens-Johnson syndrome	35.15	15.90	60	40823	24890	63423249
Coma scale abnormal	35.04	15.90	28	40855	5125	63443014
Systemic inflammatory response syndrome	34.98	15.90	29	40854	5592	63442547
Subcutaneous emphysema	34.94	15.90	15	40868	851	63447288
Inadequate aseptic technique in use of product	34.75	15.90	7	40876	21	63448118
Oropharyngeal pain	34.68	15.90	9	40874	94478	63353661
Hypocapnia	34.62	15.90	12	40871	379	63447760
Abdominal pain	34.61	15.90	87	40796	293369	63154770
Myocardial ischaemia	34.49	15.90	42	40841	12817	63435322
Macroglossia	34.46	15.90	14	40869	691	63447448
Procedural vomiting	34.36	15.90	13	40870	530	63447609
Acute postoperative sialadenitis	34.27	15.90	7	40876	23	63448116
Atrioventricular block first degree	34.19	15.90	32	40851	7241	63440898
Supraventricular tachycardia	34.11	15.90	44	40839	14227	63433912
Asthma	33.93	15.90	20	40863	127541	63320598
Hypoaesthesia	33.92	15.90	35	40848	168358	63279781
Sinus bradycardia	33.44	15.90	44	40839	14507	63433632
Dyspepsia	33.42	15.90	12	40871	102184	63345955
Myxoedema coma	33.37	15.90	12	40871	423	63447716
Face oedema	33.06	15.90	52	40831	20160	63427979
Haemodilution	32.98	15.90	9	40874	124	63448015
Extravasation	32.98	15.90	20	40863	2352	63445787
Procedural hypertension	32.83	15.90	11	40872	313	63447826
Eosinophilia	32.42	15.90	55	40828	22701	63425438
Injection site erythema	32.34	15.90	7	40876	83167	63364972
Mobility decreased	32.22	15.90	19	40864	121140	63326999
Tachypnoea	31.81	15.90	47	40836	17255	63430884
Laryngeal stenosis	31.79	15.90	15	40868	1063	63447076
Brain herniation	31.67	15.90	23	40860	3654	63444485
Death	31.57	15.90	129	40754	374252	63073887
Haematemesis	31.40	15.90	64	40819	30348	63417791
Depression	31.12	15.90	49	40834	196443	63251696
Respiratory distress	31.05	15.90	68	40815	33883	63414256
Hypotensive transfusion reaction	30.99	15.90	7	40876	41	63448098
Patent ductus arteriosus	30.85	15.90	24	40859	4226	63443913
Gaze palsy	30.71	15.90	16	40867	1404	63446735
Overdose	30.66	15.90	151	40732	114927	63333212
Product use issue	30.39	15.90	60	40823	220460	63227679
Trigemino-cardiac reflex	30.04	15.90	7	40876	48	63448091
Musculoskeletal pain	29.90	15.90	11	40872	92266	63355873
Blood pressure immeasurable	29.89	15.90	15	40868	1217	63446922
Ventricular dysfunction	29.75	15.90	20	40863	2808	63445331
Muscle spasms	29.74	15.90	34	40849	156116	63292023
Epilepsy with myoclonic-atonic seizures	29.67	15.90	8	40875	105	63448034
Myoglobinuria	29.66	15.90	10	40873	290	63447849
Aspartate aminotransferase increased	29.66	15.90	126	40757	90151	63357988
Vitamin K deficiency	29.53	15.90	11	40872	429	63447710
Somatosensory evoked potentials abnormal	29.40	15.90	5	40878	3	63448136
Hyperkalaemia	29.25	15.90	89	40794	54114	63394025
Allergy test positive	29.24	15.90	12	40871	608	63447531
White blood cell count decreased	29.06	15.90	28	40855	139076	63309063
Nasal congestion	28.87	15.90	4	40879	65656	63382483
Ischaemic cerebral infarction	28.64	15.90	15	40868	1331	63446808
Hypoxic-ischaemic encephalopathy	28.53	15.90	23	40860	4264	63443875
Oedema peripheral	28.39	15.90	49	40834	189462	63258677
Atrioventricular dissociation	28.27	15.90	9	40874	217	63447922
Therapeutic product effect decreased	27.99	15.90	51	40832	193136	63255003
Maternal exposure during pregnancy	27.75	15.90	239	40644	219823	63228316
Burkholderia test positive	27.55	15.90	9	40874	236	63447903
Dry mouth	27.48	15.90	8	40875	77855	63370284
Gastrooesophageal reflux disease	26.87	15.90	14	40869	95625	63352514
Dehydration	26.72	15.90	44	40839	173310	63274829
Myotonia	26.68	15.90	8	40875	157	63447982
Anhedonia	26.49	15.90	34	40849	10940	63437199
Acute lung injury	26.46	15.90	15	40868	1556	63446583
Muscle injury	26.45	15.90	5	40878	65340	63382799
Migraine	26.38	15.90	17	40866	103329	63344810
Skin test negative	26.26	15.90	5	40878	10	63448129
Hospitalisation	26.15	15.90	11	40872	85070	63363069
Electrocardiogram repolarisation abnormality	26.10	15.90	14	40869	1303	63446836
Oesophageal intramural haematoma	26.10	15.90	7	40876	90	63448049
Anaemia	26.06	15.90	99	40784	293331	63154808
Bradycardia foetal	26.01	15.90	10	40873	426	63447713
Muscle twitching	26.01	15.90	46	40837	19622	63428517
Lipoedema	25.83	15.90	9	40874	289	63447850
Chest discomfort	25.56	15.90	20	40863	109949	63338190
Coronary artery embolism	25.48	15.90	8	40875	184	63447955
Fibromyalgia	25.36	15.90	10	40873	80410	63367729
Normal newborn	25.28	15.90	29	40854	8312	63439827
Thyrotoxic crisis	25.26	15.90	12	40871	864	63447275
Hypothermia	25.12	15.90	37	40846	13544	63434595
Abscess neck	25.01	15.90	11	40872	662	63447477
Intensive care unit delirium	24.72	15.90	6	40877	50	63448089
Hypovolaemic shock	24.72	15.90	25	40858	6216	63441923
Tracheal injury	24.62	15.90	6	40877	51	63448088
Upper respiratory tract infection	24.59	15.90	11	40872	82036	63366103
Cough	24.58	15.90	101	40782	292642	63155497
COVID-19	24.53	15.90	22	40861	113081	63335058
Congestive hepatopathy	24.42	15.90	18	40865	2924	63445215
Bezold-Jarisch reflex	24.35	15.90	5	40878	17	63448122
Anaesthetic complication cardiac	24.35	15.90	5	40878	17	63448122
Acidosis	24.33	15.90	33	40850	11200	63436939
Endotracheal intubation	24.15	15.90	17	40866	2571	63445568
Urticaria	24.09	15.90	186	40697	165616	63282523
Dry skin	23.79	15.90	4	40879	56883	63391256
Treatment failure	23.46	15.90	59	40824	198984	63249155
Infantile apnoea	23.38	15.90	12	40871	1021	63447118
Hypersensitivity	23.33	15.90	103	40780	292582	63155557
Extubation	23.14	15.90	5	40878	23	63448116
Hyperthermia	23.10	15.90	29	40854	9127	63439012
Eyelid function disorder	23.04	15.90	8	40875	254	63447885
Therapeutic product effect incomplete	22.98	15.90	28	40855	125028	63323111
Air embolism	22.95	15.90	8	40875	257	63447882
Extrasystoles	22.91	15.90	22	40861	5138	63443001
Neck pain	22.90	15.90	8	40875	69310	63378829
CSWS syndrome	22.80	15.90	5	40878	25	63448114
Suspected product contamination	22.80	15.90	5	40878	25	63448114
Balance disorder	22.78	15.90	13	40870	84409	63363730
Hyperammonaemic encephalopathy	22.74	15.90	16	40867	2418	63445721
Mean arterial pressure decreased	22.30	15.90	7	40876	161	63447978
Ventricular arrhythmia	22.27	15.90	19	40864	3809	63444330
Euthyroid sick syndrome	22.24	15.90	6	40877	79	63448060
Encephalitis	22.20	15.90	28	40855	8852	63439287
Apnoeic attack	22.06	15.90	8	40875	289	63447850
Blister	21.88	15.90	31	40852	129783	63318356
Bronchostenosis	21.69	15.90	9	40874	469	63447670
Accidental overdose	21.67	15.90	47	40836	23262	63424877
Foetal exposure during pregnancy	21.66	15.90	57	40826	31905	63416234
Illness	21.54	15.90	3	40880	49056	63399083
Acquired macroglossia	21.52	15.90	7	40876	181	63447958
Sepsis syndrome	21.48	15.90	11	40872	931	63447208
Chronic obstructive pulmonary disease	21.12	15.90	7	40876	62679	63385460
Diabetes mellitus	21.09	15.90	5	40878	55805	63392334
Haemoperitoneum	21.04	15.90	16	40867	2725	63445414
Vision blurred	21.01	15.90	17	40866	91907	63356232
Uterine atony	20.96	15.90	7	40876	197	63447942
Post procedural fever	20.96	15.90	8	40875	334	63447805
Pulmonary alveolar haemorrhage	20.91	15.90	20	40863	4648	63443491
Tidal volume decreased	20.89	15.90	5	40878	39	63448100
Hepatitis C	20.66	15.90	21	40862	5253	63442886
Cystitis	20.63	15.90	5	40878	54986	63393153
Long QT syndrome	20.57	15.90	17	40866	3262	63444877
Atrioventricular block	20.55	15.90	25	40858	7622	63440517
Abdominal rigidity	20.54	15.90	14	40869	2010	63446129
Cholestasis	20.47	15.90	53	40830	29381	63418758
Mucosal inflammation	20.30	15.90	3	40880	46925	63401214
Epilepsy	20.14	15.90	50	40833	27015	63421124
Anuria	20.12	15.90	32	40851	12519	63435620
Extrapyramidal disorder	20.12	15.90	33	40850	13251	63434888
Osteoporosis	20.03	15.90	6	40877	57332	63390807
Emotional distress	20.01	15.90	56	40827	32493	63415646
Idiosyncratic drug reaction	19.85	15.90	10	40873	818	63447321
Syncope	19.81	15.90	28	40855	117357	63330782
Condition aggravated	19.71	15.90	165	40718	402052	63046087
Tonic clonic movements	19.69	15.90	12	40871	1423	63446716
Laryngeal obstruction	19.67	15.90	6	40877	125	63448014
Cardiac massage	19.62	15.90	4	40879	13	63448126
Gait inability	19.51	15.90	5	40878	52954	63395185
Resuscitation	19.48	15.90	11	40872	1133	63447006
Tongue oedema	19.33	15.90	19	40864	4567	63443572
Eosinophilic pneumonia acute	19.26	15.90	8	40875	418	63447721
Night sweats	19.20	15.90	4	40879	48810	63399329
Hepatic function abnormal	19.12	15.90	60	40823	37082	63411057
Ammonia increased	19.08	15.90	19	40864	4637	63443502
Inflammation	19.07	15.90	15	40868	82258	63365881
Bispectral index decreased	19.05	15.90	3	40880	0	63448139
Transcranial electrical motor evoked potential monitoring abnormal	19.05	15.90	3	40880	0	63448139
Hypernatraemia	19.04	15.90	24	40859	7585	63440554
Haemodialysis	18.95	15.90	26	40857	8921	63439218
Grimacing	18.94	15.90	8	40875	436	63447703
Adverse event	18.82	15.90	10	40873	67549	63380590
Renal tubular necrosis	18.66	15.90	30	40853	11848	63436291
Bone pain	18.58	15.90	6	40877	54635	63393504
Foetal heart rate decreased	18.53	15.90	6	40877	153	63447986
Systolic dysfunction	18.50	15.90	12	40871	1587	63446552
Burning sensation	18.46	15.90	6	40877	54401	63393738
Polyuria	18.36	15.90	25	40858	8517	63439622
Tracheal haemorrhage	18.27	15.90	6	40877	160	63447979
Extensor plantar response	18.09	15.90	11	40872	1300	63446839
Abdominal sepsis	18.02	15.90	11	40872	1308	63446831
Haematochezia	18.00	15.90	6	40877	53538	63394601
Lymphangiectasia	17.99	15.90	5	40878	74	63448065
Myocardial depression	17.96	15.90	8	40875	496	63447643
Palpitations	17.96	15.90	28	40855	112742	63335397
Lip oedema	17.94	15.90	17	40866	3907	63444232
General physical health deterioration	17.83	15.90	68	40815	201334	63246805
Nystagmus	17.80	15.90	21	40862	6199	63441940
Pancreatitis necrotising	17.75	15.90	12	40871	1700	63446439
Blood magnesium decreased	17.62	15.90	31	40852	13167	63434972
Hyperdynamic left ventricle	17.60	15.90	6	40877	180	63447959
Respiratory rate decreased	17.48	15.90	16	40867	3519	63444620
Agitation postoperative	17.22	15.90	4	40879	27	63448112
Cardiotoxicity	17.09	15.90	24	40859	8414	63439725
Nerve stimulation test abnormal	16.97	15.90	3	40880	3	63448136
Adverse drug reaction	16.70	15.90	16	40867	79698	63368441
Cardiac dysfunction	16.65	15.90	13	40870	2302	63445837
Peripheral nerve palsy	16.63	15.90	4	40879	32	63448107
Long QT syndrome congenital	16.59	15.90	5	40878	100	63448039
Visual impairment	16.49	15.90	18	40865	84428	63363711
Vertigo	16.48	15.90	9	40874	59878	63388261
Coronary artery bypass	16.38	15.90	13	40870	2356	63445783
Fluid retention	16.38	15.90	9	40874	59677	63388462
Suicidal ideation	16.30	15.90	10	40873	62411	63385728
Chemical peritonitis	16.27	15.90	5	40878	107	63448032
Ventricular asystole	16.27	15.90	5	40878	107	63448032
Pulmonary fibrosis	16.21	15.90	3	40880	39806	63408333
Fat embolism	16.18	15.90	6	40877	231	63447908
Hypertrophic cardiomyopathy	16.16	15.90	11	40872	1576	63446563
Neisseria infection	16.09	15.90	5	40878	111	63448028
Skin ulcer	15.98	15.90	4	40879	43041	63405098

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Anaphylactic shock	1921.37	15.95	708	38455	15233	34902535
Propofol infusion syndrome	1327.90	15.95	289	38874	677	34917091
Anaphylactic reaction	851.90	15.95	500	38663	31801	34885967
Hyperthermia malignant	684.29	15.95	200	38963	1977	34915791
Hypotension	598.49	15.95	964	38199	220685	34697083
Cardiac arrest	597.44	15.95	632	38531	95527	34822241
Bronchospasm	491.22	15.95	240	38923	10491	34907277
Bradycardia	484.65	15.95	505	38658	74913	34842855
Rhabdomyolysis	348.44	15.95	405	38758	67758	34850010
Delayed recovery from anaesthesia	344.26	15.95	94	39069	707	34917061
Fatigue	272.01	15.95	45	39118	370608	34547160
Serotonin syndrome	267.81	15.95	203	38960	19730	34898038
Tachycardia	244.31	15.95	381	38782	84391	34833377
Circulatory collapse	238.88	15.95	194	38969	20844	34896924
Anaesthetic complication	216.85	15.95	71	39092	1049	34916719
Metabolic acidosis	215.42	15.95	255	38908	43425	34874343
Respiratory depression	189.05	15.95	152	39011	16093	34901675
Electrocardiogram ST segment elevation	172.70	15.95	94	39069	5144	34912624
Pulseless electrical activity	169.93	15.95	104	39059	7107	34910661
Haemodynamic instability	169.23	15.95	115	39048	9408	34908360
Diarrhoea	167.01	15.95	117	39046	389795	34527973
Diabetes insipidus	166.20	15.95	76	39087	2852	34914916
Neuromuscular block prolonged	166.13	15.95	48	39115	453	34917315
Ventricular fibrillation	149.36	15.95	155	39008	22799	34894969
Status epilepticus	142.46	15.95	116	39047	12498	34905270
Shock	137.45	15.95	152	39011	24027	34893741
Arthralgia	135.26	15.95	16	39147	170025	34747743
Oxygen saturation decreased	133.26	15.95	226	38937	53592	34864176
Myoclonus	128.83	15.95	117	39046	14608	34903160
Blood pressure decreased	128.44	15.95	217	38946	51298	34866470
Drug reaction with eosinophilia and systemic symptoms	128.05	15.95	171	38992	32841	34884927
Death	127.17	15.95	156	39007	397893	34519875
Hypoxia	117.85	15.95	217	38946	54878	34862890
Airway complication of anaesthesia	114.15	15.95	28	39135	129	34917639
Intensive care unit acquired weakness	113.87	15.95	43	39120	984	34916784
Decreased appetite	113.55	15.95	24	39139	166368	34751400
Hypertriglyceridaemia	113.32	15.95	86	39077	8362	34909406
Fall	113.14	15.95	43	39120	202842	34714926
Drug interaction	109.13	15.95	521	38642	225425	34692343
Toxic epidermal necrolysis	107.67	15.95	127	39036	21519	34896249
Injury	107.27	15.95	124	39039	20563	34897205
Trigemino-cardiac reflex	103.56	15.95	27	39136	166	34917602
Product dose omission issue	101.00	15.95	9	39154	119702	34798066
Multiple organ dysfunction syndrome	100.34	15.95	247	38916	76319	34841449
Dizziness	99.48	15.95	61	39102	218460	34699308
Respiratory acidosis	99.39	15.95	65	39098	4985	34912783
Hypoxic-ischaemic encephalopathy	98.27	15.95	62	39101	4470	34913298
Procedural complication	96.40	15.95	60	39103	4223	34913545
Blood creatine phosphokinase increased	96.31	15.95	177	38986	44680	34873088
Post procedural complication	92.85	15.95	87	39076	11301	34906467
Ventricular tachycardia	91.50	15.95	130	39033	26449	34891319
Negative pressure pulmonary oedema	89.32	15.95	25	39138	208	34917560
Anaesthetic complication neurological	88.52	15.95	27	39136	312	34917456
Tachypnoea	88.50	15.95	106	39057	18246	34899522
Laryngospasm	87.96	15.95	40	39123	1481	34916287
Nausea	87.14	15.95	155	39008	339753	34578015
Intestinal ischaemia	86.58	15.95	71	39092	7723	34910045
Procedural hypotension	85.35	15.95	34	39129	902	34916866
Stress cardiomyopathy	85.12	15.95	43	39120	2016	34915752
Asthenia	84.75	15.95	90	39073	245161	34672607
Headache	84.56	15.95	61	39102	200574	34717194
Pain in extremity	82.76	15.95	20	39143	126493	34791275
Anaphylactoid shock	80.82	15.95	26	39137	362	34917406
Acute respiratory distress syndrome	79.24	15.95	120	39043	25849	34891919
Respiratory arrest	76.40	15.95	123	39040	27920	34889848
Spinal muscular atrophy	76.24	15.95	25	39138	371	34917397
Abdominal pain	73.95	15.95	46	39117	163572	34754196
Weight decreased	73.75	15.95	54	39109	176247	34741521
Pulse absent	73.28	15.95	57	39106	5746	34912022
Fear	72.21	15.95	73	39090	10403	34907365
Kounis syndrome	71.58	15.95	41	39122	2477	34915291
Apnoea	70.47	15.95	59	39104	6605	34911163
Hypercapnia	69.97	15.95	49	39114	4206	34913562
Ventricular arrhythmia	69.16	15.95	54	39109	5474	34912294
Agitation	67.70	15.95	178	38985	57221	34860547
Hypoventilation	67.32	15.95	44	39119	3370	34914398
Cardio-respiratory arrest	66.82	15.95	173	38990	55100	34862668
Peripheral swelling	66.62	15.95	5	39158	76536	34841232
Autonomic nervous system imbalance	65.80	15.95	39	39124	2512	34915256
Constipation	65.44	15.95	36	39127	136946	34780822
Arteriospasm coronary	65.26	15.95	43	39120	3339	34914429
Anaemia	64.69	15.95	101	39062	233234	34684534
Type I hypersensitivity	64.39	15.95	31	39132	1308	34916460
Brain injury	64.16	15.95	54	39109	6088	34911680
Febrile neutropenia	63.89	15.95	37	39126	136812	34780956
Seizure like phenomena	63.62	15.95	26	39137	738	34917030
Neuropathy peripheral	63.33	15.95	9	39154	83254	34834514
Dyspnoea	63.30	15.95	214	38949	376568	34541200
Vasoplegia syndrome	63.10	15.95	34	39129	1822	34915946
Nasopharyngitis	62.56	15.95	4	39159	69964	34847804
Transmission of an infectious agent via product	62.28	15.95	18	39145	170	34917598
Malaise	62.13	15.95	70	39093	185755	34732013
Renal injury	61.23	15.95	69	39094	11126	34906642
Weight increased	60.25	15.95	15	39148	93018	34824750
Blood lactic acid increased	59.90	15.95	54	39109	6674	34911094
Resuscitation	59.06	15.95	30	39133	1423	34916345
Disease progression	58.36	15.95	24	39139	108053	34809715
Drug level changed	58.27	15.95	20	39143	344	34917424
Tryptase increased	58.17	15.95	18	39145	219	34917549
Malignant neoplasm progression	57.40	15.95	14	39149	88032	34829736
Brain oedema	57.28	15.95	74	39089	13747	34904021
Erythema	56.71	15.95	223	38940	88557	34829211
Post procedural fever	56.15	15.95	16	39147	143	34917625
Cyanosis	55.52	15.95	70	39093	12694	34905074
Oedema peripheral	55.06	15.95	33	39130	119779	34797989
Allergy test negative	54.55	15.95	15	39148	116	34917652
Muscle rigidity	54.43	15.95	63	39100	10455	34907313
Anhedonia	54.38	15.95	54	39109	7531	34910237
Sinus arrest	53.97	15.95	30	39133	1710	34916058
Back pain	53.96	15.95	35	39128	121754	34796014
Pneumococcal sepsis	53.70	15.95	26	39137	1111	34916657
Torsade de pointes	52.94	15.95	52	39111	7157	34910611
Respiratory failure	52.68	15.95	251	38912	108321	34809447
Acidosis	52.40	15.95	63	39100	10882	34906886
Endotracheal intubation	52.04	15.95	36	39127	3029	34914739
Neuromuscular blockade	51.92	15.95	17	39146	251	34917517
Cough	51.89	15.95	55	39108	150085	34767683
Hospitalisation	51.63	15.95	3	39160	56899	34860869
Neonatal respiratory depression	51.52	15.95	19	39144	406	34917362
Necrosis ischaemic	50.49	15.95	17	39146	275	34917493
Feeling abnormal	50.09	15.95	6	39157	63229	34854539
Endotracheal intubation complication	49.42	15.95	18	39145	371	34917397
Brugada syndrome	49.29	15.95	22	39141	779	34916989
Dyskinesia	48.78	15.95	89	39074	22324	34895444
Insomnia	48.61	15.95	28	39135	103879	34813889
Multiple-drug resistance	48.52	15.95	43	39120	5196	34912572
Neutropenia	48.21	15.95	63	39100	156715	34761053
Product contamination	48.20	15.95	21	39142	701	34917067
Dystonia	48.00	15.95	60	39103	10785	34906983
Motor neurone disease	47.90	15.95	19	39144	498	34917270
Pulmonary alveolar haemorrhage	47.53	15.95	50	39113	7462	34910306
Stoma closure	47.28	15.95	16	39147	263	34917505
White blood cell count decreased	47.16	15.95	24	39139	95421	34822347
Electrocardiogram QRS complex prolonged	46.99	15.95	41	39122	4853	34912915
Increased bronchial secretion	46.55	15.95	28	39135	1853	34915915
Blood pressure measurement	45.57	15.95	14	39149	166	34917602
Oxygen saturation immeasurable	45.17	15.95	10	39153	26	34917742
Urinary tract infection	43.28	15.95	20	39143	84061	34833707
Hyperammonaemia	43.21	15.95	44	39119	6323	34911445
Hepatorenal failure	42.86	15.95	18	39145	548	34917220
Ischaemic cerebral infarction	42.83	15.95	23	39140	1224	34916544
Mixed liver injury	42.44	15.95	31	39132	2842	34914926
Inappropriate schedule of product administration	42.40	15.95	9	39154	62287	34855481
Electrocardiogram QT prolonged	42.29	15.95	121	39042	40831	34876937
Lower respiratory tract infection bacterial	41.55	15.95	17	39146	484	34917284
Drug ineffective	41.33	15.95	729	38434	456022	34461746
Anaphylactoid reaction	41.11	15.95	28	39135	2297	34915471
Pneumonia	40.82	15.95	239	38924	362388	34555380
Sputum increased	40.62	15.95	28	39135	2342	34915426
Anaesthetic complication cardiac	40.49	15.95	9	39154	24	34917744
Postoperative delirium	40.34	15.95	13	39150	182	34917586
Procedural haemorrhage	39.71	15.95	28	39135	2429	34915339
Metabolic disorder	39.36	15.95	35	39128	4248	34913520
Lymphadenectomy	38.59	15.95	15	39148	372	34917396
Recurrence of neuromuscular blockade	38.51	15.95	13	39150	212	34917556
Paraesthesia	38.46	15.95	12	39151	64160	34853608
Burkholderia test positive	38.34	15.95	20	39143	1003	34916765
Cardiac failure congestive	38.15	15.95	23	39140	83247	34834521
Respiratory tract infection bacterial	37.68	15.95	24	39139	1758	34916010
Rash maculo-papular	37.44	15.95	92	39071	28359	34889409
Coma blister	37.24	15.95	10	39153	70	34917698
Disease complication	37.01	15.95	28	39135	2708	34915060
Emotional distress	37.01	15.95	63	39100	14963	34902805
Chest pain	36.88	15.95	53	39110	126709	34791059
Urticaria	36.87	15.95	153	39010	62224	34855544
Airway peak pressure increased	36.65	15.95	8	39155	19	34917749
Dehydration	36.20	15.95	56	39107	129913	34787855
Hypotonic-hyporesponsive episode	36.08	15.95	8	39155	21	34917747
Opisthotonus	35.86	15.95	15	39148	452	34917316
Sinus tachycardia	35.35	15.95	67	39096	17293	34900475
Post procedural haemorrhage	35.32	15.95	45	39118	8244	34909524
Pancytopenia	34.98	15.95	33	39130	95124	34822644
Heparin-induced thrombocytopenia	34.97	15.95	37	39126	5558	34912210
Priapism	34.78	15.95	35	39128	4959	34912809
Superinfection	34.57	15.95	26	39137	2493	34915275
Delirium	34.37	15.95	118	39045	43873	34873895
Mean arterial pressure decreased	34.33	15.95	11	39152	151	34917617
Drug intolerance	34.19	15.95	12	39151	59558	34858210
Haemodialysis	34.04	15.95	50	39113	10476	34907292
Oculocardiac reflex	33.64	15.95	9	39154	62	34917706
Cellulitis	33.38	15.95	9	39154	52942	34864826
Post procedural hypotension	33.15	15.95	9	39154	66	34917702
Mechanical ventilation	33.12	15.95	23	39140	1947	34915821
Intestinal pseudo-obstruction	33.09	15.95	22	39141	1734	34916034
Therapeutic product effect prolonged	32.87	15.95	12	39151	249	34917519
Atrioventricular block complete	32.67	15.95	46	39117	9273	34908495
Drug ineffective for unapproved indication	32.61	15.95	78	39085	23637	34894131
Muscle spasms	32.59	15.95	22	39141	74979	34842789
Suspected product contamination	32.58	15.95	9	39154	71	34917697
Pulmonary oedema	32.45	15.95	122	39041	47407	34870361
Bronchial disorder	32.45	15.95	20	39143	1383	34916385
Lactic acidosis	32.34	15.95	99	39064	34673	34883095
Hepatitis fulminant	32.22	15.95	31	39132	4159	34913609
Influenza	32.16	15.95	8	39155	49658	34868110
Vomiting	31.80	15.95	156	39007	247465	34670303
Anticholinergic syndrome	31.69	15.95	19	39144	1250	34916518
Suicidal ideation	31.57	15.95	4	39159	40384	34877384
Neuroleptic malignant syndrome	31.43	15.95	65	39098	17869	34899899
General physical health deterioration	31.39	15.95	60	39103	128209	34789559
Cerebral ischaemia	31.27	15.95	37	39126	6285	34911483
Spinal cord infarction	31.13	15.95	12	39151	291	34917477
Hypotonia	30.91	15.95	41	39122	7812	34909956
Plasma cell myeloma	30.90	15.95	5	39158	42032	34875736
Product contamination microbial	30.89	15.95	15	39148	645	34917123
Depression	30.88	15.95	38	39125	97060	34820708
Partial seizures	30.68	15.95	32	39131	4728	34913040
Mucosal ulceration	30.44	15.95	17	39146	978	34916790
Areflexia	30.33	15.95	26	39137	3005	34914763
Intracranial pressure increased	29.92	15.95	29	39134	3926	34913842
Syncope	29.92	15.95	35	39128	91416	34826352
Abdominal pain upper	29.71	15.95	22	39141	71468	34846300
Balance disorder	29.52	15.95	5	39158	40649	34877119
Generalised tonic-clonic seizure	29.50	15.95	70	39093	21104	34896664
Diabetes mellitus	29.49	15.95	8	39155	46865	34870903
Nodal rhythm	29.44	15.95	19	39144	1424	34916344
Stomatitis	29.22	15.95	6	39157	42508	34875260
Symmetrical drug-related intertriginous and flexural exanthema	29.22	15.95	12	39151	345	34917423
Unresponsive to stimuli	28.99	15.95	82	39081	27487	34890281
Electrocardiogram ST-T segment elevation	28.98	15.95	5	39158	0	34917768
Hyporesponsive to stimuli	28.73	15.95	17	39146	1091	34916677
Locked-in syndrome	28.64	15.95	11	39152	264	34917504
Eosinophilia	28.56	15.95	79	39084	26143	34891625
Prostate cancer	28.52	15.95	5	39158	39644	34878124
PCO2 increased	28.41	15.95	14	39149	622	34917146
Acute pulmonary oedema	28.39	15.95	38	39125	7305	34910463
Drug withdrawal syndrome	28.10	15.95	66	39097	19768	34898000
Dyspnoea exertional	27.96	15.95	7	39156	43272	34874496
Sodium retention	27.64	15.95	8	39155	76	34917692
Chest X-ray abnormal	27.34	15.95	29	39134	4369	34913399
End-tidal CO2 increased	27.27	15.95	6	39157	15	34917753
Coagulopathy	27.11	15.95	65	39098	19724	34898044
Chromaturia	27.08	15.95	54	39109	14466	34903302
Hyperkalaemia	27.06	15.95	151	39012	69238	34848530
Bronchitis	26.70	15.95	7	39156	41956	34875812
Hypothermia	26.38	15.95	45	39118	10703	34907065
Systemic inflammatory response syndrome	26.37	15.95	35	39128	6674	34911094
Gait disturbance	26.36	15.95	34	39129	85106	34832662
Electrocardiogram T wave inversion	26.20	15.95	21	39142	2210	34915558
Coma	26.17	15.95	111	39052	45567	34872201
Renin increased	25.88	15.95	8	39155	97	34917671
Pseudocholinesterase deficiency	25.77	15.95	6	39157	21	34917747
Contusion	25.27	15.95	5	39158	36359	34881409
Disseminated intravascular coagulation	25.03	15.95	67	39096	21749	34896019
Haemoglobin decreased	24.99	15.95	62	39101	120710	34797058
Dry skin	24.69	15.95	3	39160	31284	34886484
Neonatal hypoxia	24.47	15.95	11	39152	396	34917372
Clonus	24.33	15.95	22	39141	2728	34915040
Loss of personal independence in daily activities	24.27	15.95	4	39159	33175	34884593
Pruritus	24.16	15.95	80	39083	141901	34775867
Coronary artery disease	24.07	15.95	12	39151	48293	34869475
Scoliosis	24.04	15.95	22	39141	2771	34914997
Local anaesthetic systemic toxicity	23.95	15.95	10	39153	300	34917468
Sinus bradycardia	23.92	15.95	48	39115	12915	34904853
Hepatic cytolysis	23.62	15.95	51	39112	14445	34903323
Hyponatraemia	23.62	15.95	35	39128	82656	34835112
Acidosis hyperchloraemic	23.58	15.95	11	39152	432	34917336
Neutrophil count decreased	23.56	15.95	14	39149	51090	34866678
Blood catecholamines increased	23.50	15.95	5	39158	10	34917758
Air embolism	23.45	15.95	8	39155	135	34917633
Pain	23.43	15.95	134	39029	204541	34713227
Unwanted awareness during anaesthesia	23.43	15.95	6	39157	34	34917734
Laryngeal oedema	23.36	15.95	24	39139	3484	34914284
Herpes zoster	23.34	15.95	5	39158	34394	34883374
Chronic obstructive pulmonary disease	23.12	15.95	13	39150	48905	34868863
Acute generalised exanthematous pustulosis	23.09	15.95	33	39130	6743	34911025
Pneumomediastinum	23.07	15.95	20	39143	2347	34915421
Musculoskeletal pain	23.05	15.95	4	39159	31959	34885809
Hyperthermia	23.01	15.95	42	39121	10535	34907233
Mydriasis	22.86	15.95	34	39129	7203	34910565
Brain death	22.83	15.95	21	39142	2662	34915106
Ventricular extrasystoles	22.80	15.95	45	39118	11963	34905805
Sleep disorder	22.78	15.95	4	39159	31684	34886084
Supraventricular tachycardia	22.75	15.95	43	39120	11074	34906694
Acute kidney injury	22.73	15.95	473	38690	304515	34613253
Malignant catatonia	22.65	15.95	9	39154	237	34917531
Sinusitis	22.64	15.95	9	39154	41393	34876375
Subcutaneous emphysema	22.60	15.95	15	39148	1179	34916589
Paroxysmal sympathetic hyperactivity	22.60	15.95	6	39157	40	34917728
Periorbital swelling	22.58	15.95	12	39151	625	34917143
Skin test positive	22.51	15.95	10	39153	350	34917418
Conversion disorder	22.46	15.95	10	39153	352	34917416
Post-injection delirium sedation syndrome	22.44	15.95	11	39152	483	34917285
Suspected product quality issue	22.42	15.95	8	39155	155	34917613
Motor dysfunction	22.36	15.95	33	39130	6941	34910827
Nystagmus	22.34	15.95	27	39136	4688	34913080
Electroencephalogram abnormal	22.27	15.95	20	39143	2458	34915310
Trismus	22.16	15.95	20	39143	2475	34915293
Upper airway obstruction	22.10	15.95	12	39151	653	34917115
Epistaxis	21.63	15.95	20	39143	58231	34859537
Depressed level of consciousness	21.44	15.95	100	39063	42741	34875027
Weight bearing difficulty	21.31	15.95	14	39149	1081	34916687
Dry mouth	21.27	15.95	4	39159	30161	34887607
Pupil fixed	21.25	15.95	17	39146	1784	34915984
Infusion related reaction	21.18	15.95	17	39146	53040	34864728
Septic shock	20.90	15.95	145	39018	71689	34846079
Atelectasis	20.90	15.95	55	39108	17672	34900096
Seizure	20.37	15.95	193	38970	104664	34813104
Pulmonary embolism	20.22	15.95	44	39119	89702	34828066
Euthanasia	20.21	15.95	5	39158	24	34917744
Continuous haemodiafiltration	20.09	15.95	13	39150	979	34916789
Dialysis	20.08	15.95	41	39122	11167	34906601
Hyperventilation	20.05	15.95	20	39143	2804	34914964
Hypoglycaemia	20.01	15.95	19	39144	54621	34863147
Neuromyopathy	19.59	15.95	13	39150	1021	34916747
Hypoaesthesia	19.57	15.95	24	39139	61420	34856348
Premature recovery from anaesthesia	19.52	15.95	4	39159	6	34917762
Systolic anterior motion of mitral valve	19.42	15.95	5	39158	29	34917739
Pneumothorax	19.30	15.95	56	39107	19036	34898732
Unevaluable event	19.29	15.95	80	39083	32510	34885258
Product administered to patient of inappropriate age	19.23	15.95	21	39142	3270	34914498
COVID-19	19.20	15.95	36	39127	77514	34840254
Congenital megaureter	18.92	15.95	7	39156	151	34917617
Lung consolidation	18.91	15.95	28	39135	5908	34911860
Capillary nail refill test abnormal	18.87	15.95	5	39158	33	34917735
Chills	18.75	15.95	155	39008	80888	34836880
Cardiogenic shock	18.73	15.95	69	39094	26549	34891219
Electrocardiogram ST segment depression	18.49	15.95	18	39145	2450	34915318
Blood pressure immeasurable	18.45	15.95	12	39151	911	34916857
Urinary bladder rupture	18.36	15.95	6	39157	88	34917680
Long QT syndrome	18.35	15.95	19	39144	2784	34914984
Abdominal compartment syndrome	18.10	15.95	12	39151	941	34916827
Oliguria	17.88	15.95	33	39130	8347	34909421
Demyelination	17.86	15.95	20	39143	3201	34914567
Respiratory alkalosis	17.80	15.95	15	39148	1694	34916074
Infection	17.78	15.95	48	39115	90867	34826901
Fear of death	17.77	15.95	10	39153	584	34917184
Migraine with aura	17.67	15.95	10	39153	590	34917178
Transcranial electrical motor evoked potential monitoring abnormal	17.65	15.95	4	39159	12	34917756
Skin test negative	17.61	15.95	5	39158	44	34917724
Hypernatraemia	17.57	15.95	33	39130	8457	34909311
Pleural effusion	17.54	15.95	41	39122	81505	34836263
Transurethral resection syndrome	17.41	15.95	4	39159	13	34917755
Light anaesthesia	17.39	15.95	3	39160	0	34917768
Therapeutic response prolonged	17.39	15.95	3	39160	0	34917768
Platelet count decreased	17.38	15.95	72	39091	119645	34798123
Prinzmetal angina	17.37	15.95	12	39151	1007	34916761
Haematuria traumatic	17.35	15.95	7	39156	192	34917576
Sedation complication	17.29	15.95	15	39148	1762	34916006
Procedural pain	17.26	15.95	24	39139	4782	34912986
Anaesthetic complication pulmonary	17.18	15.95	4	39159	14	34917754
Myoglobin blood increased	17.16	15.95	19	39144	3004	34914764
Palpitations	17.00	15.95	12	39151	39974	34877794
Eye movement disorder	16.95	15.95	22	39141	4105	34913663
Myocardial infarction	16.86	15.95	74	39089	121011	34796757
Electrocardiogram abnormal	16.77	15.95	34	39129	9213	34908555
Non-cardiogenic pulmonary oedema	16.77	15.95	10	39153	651	34917117
Nephrogenic diabetes insipidus	16.73	15.95	13	39150	1308	34916460
Complication of device removal	16.70	15.95	5	39158	54	34917714
Aspiration	16.64	15.95	40	39123	12154	34905614
Gastrooesophageal reflux disease	16.64	15.95	11	39152	37913	34879855
Atonic urinary bladder	16.38	15.95	4	39159	18	34917750
Respiratory distress	16.22	15.95	81	39082	35584	34882184
Intestinal obstruction	16.15	15.95	3	39160	22819	34894949
Hepatocellular injury	15.98	15.95	58	39105	22153	34895615

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Anaphylactic shock	4489.03	14.06	1566	73384	34430	79635008
Anaphylactic reaction	1955.99	14.06	1126	73824	82617	79586821
Propofol infusion syndrome	1907.35	14.06	429	74521	1554	79667884
Hypotension	1435.41	14.06	1907	73043	438410	79231028
Cardiac arrest	1337.64	14.06	1182	73768	170914	79498524
Bronchospasm	1187.24	14.06	542	74408	24317	79645121
Hyperthermia malignant	949.56	14.06	265	74685	2652	79666786
Bradycardia	815.03	14.06	808	74142	134749	79534689
Delayed recovery from anaesthesia	670.31	14.06	179	74771	1494	79667944
Serotonin syndrome	664.35	14.06	453	74497	44574	79624864
Tachycardia	610.12	14.06	792	74158	176976	79492462
Circulatory collapse	591.62	14.06	394	74556	37274	79632164
Rhabdomyolysis	559.73	14.06	582	74368	102549	79566889
Fatigue	529.49	14.06	115	74835	929612	78739826
Stress cardiomyopathy	418.01	14.06	206	74744	10960	79658478
Arthralgia	392.58	14.06	41	74909	571762	79097676
Neuromuscular block prolonged	378.76	14.06	103	74847	927	79668511
Metabolic acidosis	372.87	14.06	423	74527	82106	79587332
Haemodynamic instability	368.66	14.06	220	74730	17162	79652276
Status epilepticus	366.98	14.06	251	74699	24790	79644648
Diarrhoea	366.67	14.06	186	74764	880303	78789135
Ventricular fibrillation	355.79	14.06	271	74679	31655	79637783
Pulseless electrical activity	347.41	14.06	197	74753	13963	79655475
Drug interaction	342.35	14.06	1009	73941	414174	79255264
Anaesthetic complication	338.66	14.06	120	74830	2739	79666699
Shock	311.35	14.06	286	74664	43262	79626176
Diabetes insipidus	310.48	14.06	133	74817	5104	79664334
Ventricular tachycardia	306.83	14.06	279	74671	41656	79627782
Electrocardiogram ST segment elevation	299.74	14.06	150	74800	8247	79661191
Multiple organ dysfunction syndrome	298.11	14.06	459	74491	119787	79549651
Blood pressure decreased	297.72	14.06	415	74535	99051	79570387
Respiratory depression	291.39	14.06	227	74723	27403	79642035
Oxygen saturation decreased	280.63	14.06	464	74486	128583	79540855
Myoclonus	278.23	14.06	221	74729	27439	79641999
Fall	269.36	14.06	64	74886	487565	79181873
Procedural hypotension	251.41	14.06	88	74862	1935	79667503
Blood creatine phosphokinase increased	249.26	14.06	309	74641	65781	79603657
Hypoxia	248.73	14.06	389	74561	102854	79566584
Joint swelling	246.80	14.06	5	74945	288641	79380797
Headache	237.87	14.06	162	74788	653610	79015828
Airway complication of anaesthesia	231.83	14.06	58	74892	362	79669076
Apnoea	217.11	14.06	136	74814	11568	79657870
Respiratory acidosis	214.97	14.06	133	74817	11067	79658371
Dizziness	205.74	14.06	120	74830	526321	79143117
Pain in extremity	195.05	14.06	51	74899	364487	79304951
Nausea	194.84	14.06	379	74571	956817	78712621
Type I hypersensitivity	194.53	14.06	91	74859	4307	79665131
Anaphylactoid shock	191.83	14.06	57	74893	724	79668714
Drug intolerance	191.51	14.06	15	74935	264104	79405334
Nasopharyngitis	191.08	14.06	12	74938	253869	79415569
Post procedural complication	191.06	14.06	167	74783	23662	79645776
Procedural complication	187.59	14.06	108	74842	7875	79661563
Malaise	186.69	14.06	115	74835	489754	79179684
Intestinal ischaemia	184.95	14.06	129	74821	13141	79656297
Alopecia	183.32	14.06	8	74942	231347	79438091
Myoglobin urine present	181.00	14.06	57	74893	890	79668548
Peripheral swelling	178.00	14.06	22	74928	269595	79399843
Laryngospasm	177.71	14.06	83	74867	3914	79665524
Decreased appetite	177.37	14.06	51	74899	342367	79327071
Dystonia	175.66	14.06	152	74798	21247	79648191
Weight increased	172.85	14.06	27	74923	277359	79392079
Abdominal discomfort	171.67	14.06	18	74932	250709	79418729
Drug reaction with eosinophilia and systemic symptoms	171.54	14.06	254	74696	63990	79605448
Kounis syndrome	169.24	14.06	82	74868	4200	79665238
Cardio-respiratory arrest	166.96	14.06	336	74614	108174	79561264
Product dose omission issue	166.36	14.06	19	74931	247518	79421920
Rheumatoid arthritis	162.59	14.06	8	74942	208462	79460976
Hypertriglyceridaemia	161.74	14.06	117	74833	12623	79656815
Anaesthetic complication neurological	158.17	14.06	47	74903	597	79668841
Torsade de pointes	156.14	14.06	136	74814	19176	79650262
Pain	156.05	14.06	264	74686	703538	78965900
Tryptase increased	153.20	14.06	46	74904	607	79668831
Arteriospasm coronary	152.87	14.06	89	74861	6627	79662811
Hypoventilation	152.02	14.06	91	74859	7133	79662305
Dyspnoea	146.59	14.06	373	74577	856652	78812786
Unwanted awareness during anaesthesia	145.49	14.06	38	74912	288	79669150
Intensive care unit acquired weakness	144.71	14.06	58	74892	1875	79667563
Trigemino-cardiac reflex	142.77	14.06	36	74914	233	79669205
Weight decreased	141.42	14.06	79	74871	355119	79314319
Arthropathy	140.70	14.06	6	74944	177105	79492333
Anaphylactoid reaction	139.94	14.06	78	74872	5344	79664094
Allergy test negative	139.80	14.06	37	74913	297	79669141
Sinusitis	136.51	14.06	13	74937	195488	79473950
Multiple-drug resistance	135.47	14.06	91	74859	8717	79660721
Generalised tonic-clonic seizure	133.95	14.06	185	74765	43725	79625713
Respiratory arrest	130.47	14.06	211	74739	57339	79612099
Acute respiratory distress syndrome	130.45	14.06	183	74767	43884	79625554
Agitation	130.42	14.06	289	74661	99426	79570012
Toxic epidermal necrolysis	128.81	14.06	183	74767	44398	79625040
Respiratory failure	128.43	14.06	418	74532	180493	79488945
Anticholinergic syndrome	127.38	14.06	64	74886	3547	79665891
Unresponsive to stimuli	125.74	14.06	204	74746	55584	79613854
Asthenia	125.63	14.06	179	74771	511510	79157928
Brain oedema	119.99	14.06	133	74817	25130	79644308
Infusion related reaction	119.69	14.06	34	74916	230203	79439235
Constipation	118.46	14.06	59	74891	282991	79386447
Vasoplegia syndrome	118.34	14.06	61	74889	3569	79665869
Hypoxic-ischaemic encephalopathy	115.99	14.06	79	74871	7741	79661697
Electrocardiogram QT prolonged	114.87	14.06	259	74691	90127	79579311
Clonus	113.26	14.06	74	74876	6766	79662672
Tachypnoea	113.02	14.06	145	74805	31918	79637520
Opisthotonus	112.97	14.06	37	74913	659	79668779
Hypercapnia	111.02	14.06	81	74869	8854	79660584
Labile blood pressure	110.22	14.06	50	74900	2203	79667235
Contusion	109.06	14.06	8	74942	148768	79520670
Abdominal pain	108.28	14.06	124	74826	389445	79279993
Erythema	108.14	14.06	456	74494	222834	79446604
Insomnia	105.79	14.06	49	74901	245121	79424317
Pruritus	105.01	14.06	130	74820	394518	79274920
Pulse absent	104.31	14.06	82	74868	10021	79659417
Necrosis ischaemic	103.97	14.06	39	74911	1051	79668387
Swelling	103.76	14.06	37	74913	216674	79452764
Blood lactic acid increased	103.53	14.06	90	74860	12654	79656784
PCO2 increased	103.39	14.06	45	74905	1795	79667643
Endotracheal intubation complication	103.08	14.06	36	74914	786	79668652
Fear	101.41	14.06	114	74836	21872	79647566
Seizure	100.42	14.06	397	74553	188437	79481001
Drug ineffective for unapproved indication	100.36	14.06	176	74774	51062	79618376
Systemic lupus erythematosus	100.04	14.06	3	74947	121146	79548292
Negative pressure pulmonary oedema	97.87	14.06	26	74924	212	79669226
Partial seizures	97.32	14.06	75	74875	8903	79660535
Dyskinesia	97.21	14.06	161	74789	44612	79624826
Anaesthetic complication pulmonary	96.84	14.06	21	74929	61	79669377
Stomatitis	96.74	14.06	12	74938	146745	79522693
Muscle rigidity	96.71	14.06	106	74844	19776	79649662
Acute generalised exanthematous pustulosis	96.36	14.06	99	74851	17155	79652283
Mydriasis	96.31	14.06	100	74850	17543	79651895
Renal injury	96.12	14.06	98	74852	16829	79652609
Arthritis	94.30	14.06	3	74947	114877	79554561
Urinary tract infection	93.07	14.06	73	74877	274439	79394999
Sinus tachycardia	92.90	14.06	142	74808	36766	79632672
Pulmonary oedema	92.83	14.06	235	74715	88019	79581419
Cardiogenic shock	91.37	14.06	151	74799	41763	79627675
Electrocardiogram QRS complex prolonged	91.03	14.06	78	74872	10755	79658683
Back pain	90.97	14.06	91	74859	304089	79365349
Mitochondrial DNA mutation	90.89	14.06	28	74922	405	79669033
Neuromuscular blockade	90.79	14.06	30	74920	550	79668888
Disseminated intravascular coagulation	88.95	14.06	137	74813	35705	79633733
Amylase increased	88.72	14.06	78	74872	11131	79658307
Inappropriate schedule of product administration	87.90	14.06	11	74939	133617	79535821
Ventricular arrhythmia	87.52	14.06	70	74880	8770	79660668
Musculoskeletal stiffness	87.03	14.06	28	74922	174980	79494458
Postoperative delirium	87.02	14.06	26	74924	337	79669101
Death	86.58	14.06	260	74690	566254	79103184
Neuropathy peripheral	85.19	14.06	15	74935	141290	79528148
Neutropenia	84.98	14.06	87	74863	287623	79381815
Bronchitis	82.97	14.06	12	74938	130632	79538806
Anaemia	82.71	14.06	185	74765	444830	79224608
Influenza	82.08	14.06	12	74938	129594	79539844
Laryngeal oedema	81.82	14.06	65	74885	8064	79661374
Disease progression	80.83	14.06	36	74914	184326	79485112
Abdominal pain upper	80.41	14.06	56	74894	223763	79445675
Injection site pain	80	14.06	13	74937	129825	79539613
Oedema peripheral	78.30	14.06	73	74877	252215	79417223
Coagulopathy	77.52	14.06	129	74821	35877	79633561
Hepatorenal failure	77.37	14.06	33	74917	1252	79668186
Resuscitation	77.22	14.06	40	74910	2364	79667074
Cough	77.07	14.06	142	74808	366647	79302791
Malignant neoplasm progression	76.60	14.06	17	74933	135973	79533465
Pneumonia	76.52	14.06	340	74610	659906	79009532
Discomfort	76.46	14.06	13	74937	125604	79543834
Atrioventricular block complete	76.39	14.06	86	74864	16524	79652914
Spinal muscular atrophy	75.96	14.06	24	74926	379	79669059
Intra-abdominal pressure increased	75.64	14.06	22	74928	258	79669180
Anhedonia	75.21	14.06	81	74869	14817	79654621
Post procedural haemorrhage	75.20	14.06	78	74872	13666	79655772
Therapeutic product effect prolonged	75.08	14.06	26	74924	553	79668885
Acute pulmonary oedema	74.72	14.06	79	74871	14151	79655287
Encephalopathy	74.58	14.06	183	74767	67214	79602224
Oliguria	74.25	14.06	84	74866	16225	79653213
Chest pain	73.99	14.06	94	74856	282210	79387228
Acidosis	73.81	14.06	92	74858	19670	79649768
Procedural haemorrhage	73.28	14.06	49	74901	4657	79664781
Wound	73.01	14.06	11	74939	116168	79553270
Ventricular extrasystoles	72.43	14.06	91	74859	19613	79649825
Seizure like phenomena	71.52	14.06	35	74915	1832	79667606
Feeling abnormal	71.52	14.06	30	74920	159169	79510269
Psoriasis	71.24	14.06	3	74947	89584	79579854
Cyanosis	70.72	14.06	102	74848	25080	79644358
Pulmonary alveolar haemorrhage	69.96	14.06	69	74881	11388	79658050
Drug ineffective	69.83	14.06	1412	73538	1079501	78589937
Gait disturbance	69.28	14.06	56	74894	207450	79461988
Electroencephalogram abnormal	69.19	14.06	50	74900	5384	79664054
Dyspepsia	68.97	14.06	10	74940	108677	79560761
Loss of personal independence in daily activities	68.55	14.06	8	74942	102572	79566866
Recurrence of neuromuscular blockade	68.53	14.06	21	74929	298	79669140
Neuroleptic malignant syndrome	67.91	14.06	105	74845	27454	79641984
Lower respiratory tract infection	67.28	14.06	19	74931	129201	79540237
Febrile neutropenia	66.90	14.06	71	74879	230928	79438510
Ischaemic cerebral infarction	66.87	14.06	37	74913	2498	79666940
Delirium	66.84	14.06	203	74747	84424	79585014
Stridor	66.76	14.06	49	74901	5404	79664034
White blood cell count decreased	66.45	14.06	48	74902	188240	79481198
Coma	66.41	14.06	227	74723	100422	79569016
Toxic encephalopathy	66.36	14.06	67	74883	11373	79658065
Endotracheal intubation	66.24	14.06	46	74904	4651	79664787
Infection	65.94	14.06	78	74872	241634	79427804
Acidosis hyperchloraemic	65.59	14.06	26	74924	816	79668622
Upper airway obstruction	64.56	14.06	30	74920	1398	79668040
Suspected product quality issue	64.43	14.06	20	74930	297	79669141
Premature delivery	64.36	14.06	94	74856	23373	79646065
Septic shock	64.29	14.06	257	74693	122544	79546894
Contraindicated product administered	64.13	14.06	34	74916	157504	79511934
Rash maculo-papular	63.90	14.06	154	74796	55924	79613514
Local anaesthetic systemic toxicity	63.24	14.06	27	74923	1027	79668411
Dehydration	62.60	14.06	85	74865	248102	79421336
Ventricular hypokinesia	62.53	14.06	59	74891	9220	79660218
Carcinoid crisis	62.12	14.06	22	74928	501	79668937
Post procedural fever	61.92	14.06	22	74928	506	79668932
PO2 increased	61.52	14.06	30	74920	1558	79667880
Herpes zoster	60.39	14.06	8	74942	93075	79576363
Renal failure	59.98	14.06	358	74592	200610	79468828
Gastrointestinal disorder	59.96	14.06	20	74930	122185	79547253
Muscle spasms	59.78	14.06	46	74904	174684	79494754
Anaesthetic complication cardiac	59.25	14.06	14	74936	66	79669372
Brugada syndrome	59.07	14.06	27	74923	1211	79668227
Hospitalisation	59.03	14.06	9	74941	94227	79575211
CSF oligoclonal band present	58.86	14.06	20	74930	401	79669037
Brain injury	58.81	14.06	63	74887	11454	79657984
Airway peak pressure increased	58.62	14.06	19	74931	327	79669111
Troponin increased	58.52	14.06	81	74869	19174	79650264
Renal impairment	58.41	14.06	298	74652	157485	79511953
Renal ischaemia	57.52	14.06	26	74924	1136	79668302
Systemic inflammatory response syndrome	57.28	14.06	62	74888	11403	79658035
Skin test positive	57.26	14.06	26	74924	1148	79668290
Sinus arrest	57.09	14.06	38	74912	3584	79665854
Blood pH decreased	56.93	14.06	42	74908	4669	79664769
Lactic acidosis	56.71	14.06	170	74780	70189	79599249
Injury	56.68	14.06	181	74769	77315	79592123
Acute kidney injury	56.42	14.06	740	74210	518664	79150774
Hepatocellular injury	55.62	14.06	132	74818	47461	79621977
Suspected product contamination	55.60	14.06	14	74936	90	79669348
Mucosal inflammation	55.56	14.06	4	74946	75576	79593862
Product contamination	55.50	14.06	26	74924	1234	79668204
Musculoskeletal pain	55.26	14.06	14	74936	102340	79567098
Mobility decreased	54.90	14.06	23	74927	122152	79547286
General physical health deterioration	54.77	14.06	110	74840	275128	79394310
Haemodialysis	54.57	14.06	76	74874	18092	79651346
Hypoaesthesia	54.33	14.06	53	74897	179299	79490139
Exposure during pregnancy	54.01	14.06	213	74737	100919	79568519
Blood gases abnormal	54.00	14.06	25	74925	1155	79668283
Oculogyric crisis	53.98	14.06	34	74916	2918	79666520
Dry mouth	53.80	14.06	9	74941	88010	79581428
Nasal congestion	53.65	14.06	5	74945	76547	79592891
Hyperkalaemia	53.28	14.06	231	74719	114167	79555271
Hepatic failure	53.27	14.06	152	74798	61060	79608378
Vomiting	53.19	14.06	387	74563	665441	79003997
Drug level changed	52.77	14.06	20	74930	555	79668883
Posterior reversible encephalopathy syndrome	52.40	14.06	91	74859	26190	79643248
Hepatic ischaemia	52.20	14.06	24	74926	1091	79668347
Eosinophilia	52.17	14.06	125	74825	45220	79624218
Hyperammonaemia	51.98	14.06	58	74892	11035	79658403
Urticaria	51.52	14.06	324	74626	184877	79484561
Hepatitis acute	51.21	14.06	68	74882	15474	79653964
Asthma	50.93	14.06	32	74918	135063	79534375
Maternal exposure during delivery	50.86	14.06	25	74925	1321	79668117
End-tidal CO2 decreased	50.71	14.06	11	74939	32	79669406
Hyperreflexia	50.27	14.06	50	74900	8335	79661103
Increased bronchial secretion	50.27	14.06	34	74916	3293	79666145
Syncope	49.91	14.06	57	74893	179392	79490046
Oxygen saturation immeasurable	49.74	14.06	11	74939	36	79669402
Angioedema	49.72	14.06	171	74779	75864	79593574
Supraventricular tachycardia	49.57	14.06	79	74871	21191	79648247
Subcutaneous emphysema	49.57	14.06	27	74923	1767	79667671
Arrhythmia	49.34	14.06	148	74802	61124	79608314
Depression	49.07	14.06	80	74870	216710	79452728
Mean arterial pressure decreased	48.94	14.06	17	74933	365	79669073
Balance disorder	48.81	14.06	16	74934	98841	79570597
Unmasking of previously unidentified disease	48.78	14.06	28	74922	2029	79667409
Sinus bradycardia	48.49	14.06	86	74864	25161	79644277
Stoma closure	48.44	14.06	16	74934	293	79669145
Foetal death	48.29	14.06	48	74902	7996	79661442
Blood pressure immeasurable	48.19	14.06	28	74922	2076	79667362
Motor neurone disease	48.15	14.06	19	74931	589	79668849
Brain death	47.95	14.06	41	74909	5636	79663802
Pneumatosis	47.55	14.06	21	74929	868	79668570
Priapism	47.45	14.06	37	74913	4468	79664970
Impaired healing	47.30	14.06	12	74938	87643	79581795
Myoclonic epilepsy	47.21	14.06	27	74923	1943	79667495
Irritable bowel syndrome	46.61	14.06	3	74947	62238	79607200
Autonomic nervous system imbalance	46.55	14.06	37	74913	4593	79664845
Cardiac output decreased	46.23	14.06	26	74924	1812	79667626
Respiratory distress	46.11	14.06	140	74810	58199	79611239
Acute hepatic failure	45.97	14.06	93	74857	30020	79639418
Depressed level of consciousness	45.64	14.06	196	74754	96456	79572982
COVID-19	45.03	14.06	49	74901	157625	79511813
Emotional distress	44.71	14.06	109	74841	39860	79629578
Gastrooesophageal reflux disease	44.67	14.06	21	74929	104225	79565213
Hepatic cytolysis	44.03	14.06	86	74864	27065	79642373
Diabetes mellitus	43.73	14.06	10	74940	78380	79591058
Injection site erythema	43.58	14.06	10	74940	78187	79591251
Hyperthermia	43.43	14.06	68	74882	17969	79651469
Mental status changes postoperative	43.26	14.06	13	74937	172	79669266
Mixed liver injury	43.25	14.06	44	74906	7534	79661904
Product contamination microbial	43.16	14.06	20	74930	926	79668512
Pneumococcal sepsis	43.13	14.06	24	74926	1638	79667800
Phrenic nerve paralysis	43.01	14.06	15	74935	326	79669112
Paraesthesia	42.84	14.06	62	74888	176261	79493177
Electrocardiogram ST segment depression	42.78	14.06	36	74914	4842	79664596
Air embolism	42.66	14.06	16	74934	431	79669007
Hepatitis	42.43	14.06	132	74818	55595	79613843
Acute postoperative sialadenitis	42.35	14.06	10	74940	47	79669391
Hypotonia	41.93	14.06	56	74894	12814	79656624
Gene mutation	41.90	14.06	28	74922	2658	79666780
Macroglossia	41.86	14.06	21	74929	1160	79668278
Dry skin	41.45	14.06	7	74943	67988	79601450
Cardiac failure congestive	40.95	14.06	44	74906	142358	79527080
Oxygen saturation abnormal	40.56	14.06	34	74916	4548	79664890
Chest discomfort	40.42	14.06	42	74908	138002	79531436
Hypocapnia	40.33	14.06	17	74933	626	79668812
Pseudocholinesterase deficiency	40.27	14.06	12	74938	154	79669284
Left ventricle outflow tract obstruction	40.21	14.06	15	74935	398	79669040
Chronic obstructive pulmonary disease	40.15	14.06	15	74935	85404	79584034
Palpitations	40.00	14.06	36	74914	126574	79542864
Chromaturia	39.88	14.06	80	74870	25666	79643772
Upper respiratory tract infection	39.63	14.06	18	74932	91150	79578288
Procedural hypertension	39.52	14.06	14	74936	319	79669119
Muscle relaxant therapy	39.44	14.06	12	74938	166	79669272
Therapeutic product effect incomplete	39.37	14.06	45	74905	141600	79527838
Skin test negative	39.29	14.06	9	74941	36	79669402
Aspiration	39.15	14.06	69	74881	20089	79649349
Unevaluable event	38.99	14.06	128	74822	55457	79613981
Mechanical ventilation	38.81	14.06	27	74923	2737	79666701
Wrong product administered	38.63	14.06	45	74905	8967	79660471
Migraine	38.46	14.06	17	74933	87476	79581962
Fibromyalgia	38.40	14.06	7	74943	64333	79605105
Respiratory tract infection bacterial	38.18	14.06	24	74926	2053	79667385
Dyspnoea exertional	38.15	14.06	17	74933	87056	79582382
Hypothermia	38.05	14.06	73	74877	22673	79646765
Pneumothorax	38.03	14.06	83	74867	28240	79641198
Nodal rhythm	38.00	14.06	28	74922	3107	79666331
Extravasation	37.77	14.06	30	74920	3720	79665718
Alanine aminotransferase increased	37.75	14.06	272	74678	162298	79507140
Thyrotoxic crisis	37.36	14.06	20	74930	1264	79668174
Confusion postoperative	36.83	14.06	12	74938	210	79669228
Long QT syndrome	36.61	14.06	36	74914	5919	79663519
Suicidal ideation	36.57	14.06	13	74937	76327	79593111
Hepatorenal syndrome	36.53	14.06	31	74919	4218	79665220
Metabolic disorder	36.36	14.06	44	74906	9126	79660312
Inadequate aseptic technique in use of product	36.00	14.06	10	74940	98	79669340
Neck pain	35.86	14.06	13	74937	75404	79594034
Hepatitis fulminant	35.81	14.06	39	74911	7223	79662215
Blood lactate dehydrogenase increased	35.77	14.06	99	74851	39071	79630367
Hypernatraemia	35.52	14.06	55	74895	14396	79655042
Intentional product use issue	35.48	14.06	55	74895	152057	79517381
Blood pressure measurement	35.33	14.06	14	74936	439	79668999
Pleocytosis	35.23	14.06	20	74930	1419	79668019
Oculocardiac reflex	35.21	14.06	9	74941	62	79669376
Post-injection delirium sedation syndrome	35.14	14.06	15	74935	570	79668868
Allergy test positive	35.12	14.06	16	74934	712	79668726
Areflexia	35.04	14.06	34	74916	5500	79663938
Tracheal deviation	35.03	14.06	11	74939	170	79669268
Fluid retention	34.99	14.06	11	74939	69798	79599640
Drug withdrawal syndrome	34.98	14.06	91	74859	34627	79634811
Cardiovascular insufficiency	34.73	14.06	26	74924	2955	79666483
Hyperlactacidaemia	34.73	14.06	34	74916	5561	79663877
Oropharyngeal pain	34.66	14.06	31	74919	109322	79560116
Neoplasm progression	34.60	14.06	4	74946	51678	79617760
Myoglobinuria	34.46	14.06	18	74932	1082	79668356
Spinal cord infarction	34.24	14.06	15	74935	608	79668830
Transcranial electrical motor evoked potential monitoring abnormal	34.12	14.06	7	74943	14	79669424
Atelectasis	34.00	14.06	86	74864	32171	79637267
Tonic clonic movements	33.88	14.06	23	74927	2241	79667197
Ill-defined disorder	33.70	14.06	10	74940	65865	79603573
Nystagmus	33.66	14.06	44	74906	9860	79659578
Plasma cell myeloma	33.55	14.06	5	74945	53254	79616184
Myoglobin blood increased	33.45	14.06	26	74924	3125	79666313
Premature recovery from anaesthesia	33.39	14.06	6	74944	3	79669435
Post procedural hypotension	33.19	14.06	9	74941	80	79669358
Intracranial pressure increased	33.11	14.06	40	74910	8282	79661156
Perforation	32.72	14.06	19	74931	1407	79668031
Sleep disorder	32.69	14.06	20	74930	85657	79583781
Vertigo	32.69	14.06	12	74938	69070	79600368
Ultrasound ovary abnormal	32.42	14.06	9	74941	88	79669350
End-tidal CO2 increased	32.37	14.06	7	74943	20	79669418
Hypovolaemia	32.36	14.06	59	74891	17632	79651806
Pancytopenia	32.30	14.06	67	74883	165678	79503760
Paralysis	32.17	14.06	50	74900	13127	79656311
Symmetrical drug-related intertriginous and flexural exanthema	32.12	14.06	16	74934	870	79668568
Hyponatraemia	32.10	14.06	75	74875	177773	79491665
Motor dysfunction	31.99	14.06	53	74897	14680	79654758
Myotonia	31.85	14.06	11	74939	232	79669206
Depressed mood	31.85	14.06	4	74946	48476	79620962
Systolic anterior motion of mitral valve	31.83	14.06	8	74942	51	79669387
Neutrophil count decreased	31.79	14.06	25	74925	93934	79575504
Face oedema	31.76	14.06	77	74873	28059	79641379
Atrioventricular dissociation	31.63	14.06	12	74938	334	79669104
Haematochezia	31.36	14.06	22	74928	87623	79581815
Cholestasis	31.32	14.06	114	74836	51995	79617443
Bone pain	31.32	14.06	7	74943	55735	79613703
Lower respiratory tract infection bacterial	30.97	14.06	16	74934	940	79668498
Cystitis	30.91	14.06	6	74944	52726	79616712
C-reactive protein increased	30.72	14.06	46	74904	128981	79540457
Disease complication	30.64	14.06	30	74920	4907	79664531
Pancreatitis necrotising	30.54	14.06	27	74923	3881	79665557
Atrioventricular block second degree	30.49	14.06	36	74914	7276	79662162
Irregular breathing	30.19	14.06	13	74937	505	79668933
Illness	30.16	14.06	4	74946	46507	79622931
Change in seizure presentation	30.09	14.06	13	74937	509	79668929
Osteoporosis	29.99	14.06	7	74943	54105	79615333
Electrocardiogram ST-T segment elevation	29.85	14.06	5	74945	0	79669438
Bispectral index decreased	29.85	14.06	5	74945	0	79669438
Rash pruritic	29.82	14.06	15	74935	71614	79597824
Haemoglobin decreased	29.65	14.06	108	74842	222011	79447427
Muscle injury	29.60	14.06	5	74945	48556	79620882
Acute lung injury	29.52	14.06	24	74926	3076	79666362
Blood bicarbonate decreased	29.37	14.06	30	74920	5161	79664277
Productive cough	29.26	14.06	24	74926	88307	79581131
Laryngeal stenosis	29.03	14.06	16	74934	1072	79668366
Cellulitis	28.86	14.06	36	74914	109024	79560414
Transient ischaemic attack	28.84	14.06	7	74943	52688	79616750
Locked-in syndrome	28.75	14.06	14	74936	725	79668713
Intestinal pseudo-obstruction	28.72	14.06	22	74928	2587	79666851
Rhinorrhoea	28.69	14.06	18	74932	76056	79593382
Burkholderia test positive	28.67	14.06	13	74937	572	79668866
Sputum increased	28.57	14.06	28	74922	4585	79664853
Extrasystoles	28.44	14.06	35	74915	7384	79662054
Hepatic enzyme increased	28.38	14.06	83	74867	182527	79486911
Night sweats	28.36	14.06	7	74943	52088	79617350
Phaeochromocytoma crisis	28.34	14.06	11	74939	326	79669112
Heparin-induced thrombocytopenia	28.33	14.06	40	74910	9642	79659796
Brain herniation	28.28	14.06	35	74915	7428	79662010
Fibrinolysis	28.14	14.06	8	74942	86	79669352
Coma blister	28.10	14.06	10	74940	231	79669207
Multiple sclerosis relapse	27.90	14.06	5	74945	46528	79622910
Incorrect drug administration rate	27.90	14.06	26	74924	4000	79665438
Joint stiffness	27.74	14.06	3	74947	40827	79628611
Bronchial disorder	27.43	14.06	21	74929	2468	79666970
Ventricular dysfunction	27.38	14.06	31	74919	5992	79663446
Epistaxis	27.28	14.06	39	74911	111476	79557962
Viral infection	27.19	14.06	4	74946	43012	79626426
Coma scale abnormal	27.11	14.06	37	74913	8641	79660797
Maternal exposure during pregnancy	26.97	14.06	220	74730	136318	79533120
Apnoeic attack	26.91	14.06	13	74937	661	79668777
Hot flush	26.88	14.06	9	74941	54868	79614570
Hyperventilation	26.70	14.06	35	74915	7864	79661574
Cerebral ischaemia	26.67	14.06	42	74908	11153	79658285
Pupil fixed	26.60	14.06	24	74926	3542	79665896
Epilepsy with myoclonic-atonic seizures	26.47	14.06	8	74942	108	79669330
Respiratory alkalosis	26.39	14.06	26	74924	4285	79665153
Eye movement disorder	26.31	14.06	35	74915	7976	79661462
Polyuria	26.12	14.06	49	74901	14965	79654473
Transaminases increased	26.03	14.06	107	74843	51636	79617802
Pneumomediastinum	26.03	14.06	24	74926	3643	79665795
Adverse event	26.00	14.06	12	74938	60202	79609236
Gaze palsy	25.99	14.06	22	74928	2983	79666455
Vision blurred	25.94	14.06	37	74913	105861	79563577
Chemical peritonitis	25.94	14.06	10	74940	291	79669147
Atrioventricular block	25.90	14.06	47	74903	13994	79655444
Atrioventricular block first degree	25.88	14.06	44	74906	12447	79656991
Dialysis	25.81	14.06	55	74895	18407	79651031
Superinfection	25.35	14.06	27	74923	4875	79664563
Dysgeusia	25.30	14.06	11	74939	57166	79612272
Leukocytosis	25.22	14.06	94	74856	43361	79626077
Overdose	24.99	14.06	274	74676	183932	79485506
Malignant catatonia	24.92	14.06	11	74939	454	79668984
Hypotensive transfusion reaction	24.81	14.06	7	74943	73	79669365
Tongue oedema	24.78	14.06	32	74918	7085	79662353
Skin ulcer	24.63	14.06	10	74940	54140	79615298
Prinzmetal angina	24.62	14.06	17	74933	1703	79667735
Trismus	24.62	14.06	28	74922	5439	79663999
Extrapyramidal disorder	24.46	14.06	61	74889	22618	79646820
Blister	24.39	14.06	47	74903	119429	79550009
Lymphadenectomy	24.28	14.06	15	74935	1244	79668194
Product administered to patient of inappropriate age	24.26	14.06	28	74922	5525	79663913
Clonic convulsion	24.25	14.06	15	74935	1247	79668191
Procedural nausea	24.16	14.06	13	74937	830	79668608
Long QT syndrome congenital	24.09	14.06	8	74942	149	79669289
Osteoarthritis	23.97	14.06	28	74922	87281	79582157
Lymphadenopathy	23.95	14.06	10	74940	53237	79616201
Altered state of consciousness	23.95	14.06	93	74857	43729	79625709
Therapeutic response prolonged	23.88	14.06	4	74946	0	79669438
Haemodilution	23.85	14.06	8	74942	154	79669284
Blood potassium increased	23.83	14.06	71	74879	29204	79640234
Blood pressure fluctuation	23.82	14.06	17	74933	67128	79602310
Visual impairment	23.77	14.06	31	74919	92100	79577338
Abdominal compartment syndrome	23.37	14.06	16	74934	1581	79667857
Mucosal ulceration	23.31	14.06	17	74933	1856	79667582
Cardiovascular disorder	23.27	14.06	52	74898	17973	79651465
Osteonecrosis of jaw	23.16	14.06	6	74944	43220	79626218
Vitamin K deficiency	23.06	14.06	12	74938	716	79668722
Orthostatic hypotension	23.02	14.06	12	74938	56152	79613286
Blood pressure systolic decreased	22.93	14.06	39	74911	11037	79658401
Symptom masked	22.92	14.06	15	74935	1375	79668063
Myxoedema coma	22.92	14.06	12	74938	725	79668713
Mechanical ventilation complication	22.91	14.06	6	74944	46	79669392
Angina pectoris	22.82	14.06	10	74940	51722	79617716
Basal cell carcinoma	22.44	14.06	4	74946	37371	79632067
Nephrolithiasis	22.42	14.06	11	74939	53280	79616158
Myalgia	22.38	14.06	94	74856	185547	79483891
Pneumonia aspiration	22.37	14.06	123	74827	66844	79602594
Encephalitis autoimmune	22.36	14.06	18	74932	2276	79667162
Chest X-ray abnormal	22.23	14.06	32	74918	7851	79661587
Continuous haemodiafiltration	22.20	14.06	17	74933	1999	79667439
Respiratory tract infection	22.14	14.06	9	74941	48680	79620758
Cerebral hypoperfusion	22.14	14.06	12	74938	778	79668660
Procedural vomiting	22.12	14.06	12	74938	779	79668659
Dry eye	22.07	14.06	4	74946	36927	79632511
Cardiac massage	22.03	14.06	5	74945	19	79669419
Treatment failure	22.03	14.06	84	74866	170402	79499036
Injection site reaction	22.02	14.06	12	74938	54773	79614665
Intensive care unit delirium	21.96	14.06	6	74944	55	79669383
Memory impairment	21.91	14.06	45	74905	111689	79557749
Product use issue	21.89	14.06	112	74838	209710	79459728
Non-cardiogenic pulmonary oedema	21.89	14.06	15	74935	1484	79667954
Coronary artery embolism	21.84	14.06	9	74941	313	79669125
Eyelid oedema	21.76	14.06	43	74907	13644	79655794
Oesophageal intramural haematoma	21.73	14.06	7	74943	118	79669320
Sepsis syndrome	21.73	14.06	15	74935	1502	79667936
Femur fracture	21.42	14.06	5	74945	38647	79630791
Lip oedema	21.37	14.06	28	74922	6288	79663150
Throat irritation	21.34	14.06	6	74944	40940	79628498
Bezold-Jarisch reflex	21.26	14.06	5	74945	23	79669415
Anuria	21.17	14.06	55	74895	20908	79648530
Palmar-plantar erythrodysaesthesia syndrome	21.13	14.06	3	74947	33131	79636307
Muscle twitching	21.06	14.06	61	74889	24703	79644735
Left ventricular dysfunction	20.80	14.06	52	74898	19309	79650129
Gait inability	20.80	14.06	15	74935	58902	79610536
Obstructive airways disorder	20.78	14.06	71	74879	31388	79638050
CSWS syndrome	20.76	14.06	5	74945	26	79669412
Hyperammonaemic encephalopathy	20.70	14.06	24	74926	4758	79664680
Shock haemorrhagic	20.64	14.06	53	74897	20007	79649431
Burning sensation	20.60	14.06	15	74935	58617	79610821
Tracheal injury	20.58	14.06	6	74944	71	79669367
Normal newborn	20.37	14.06	29	74921	7043	79662395
Blood glucose increased	20.33	14.06	49	74901	114926	79554512
Pneumonia staphylococcal	20.33	14.06	24	74926	4850	79664588
Pancreatitis	20.32	14.06	122	74828	68453	79600985
Condition aggravated	20.30	14.06	340	74610	500784	79168654
Pain in jaw	20.23	14.06	9	74941	46142	79623296
Aspartate aminotransferase increased	20.09	14.06	209	74741	138432	79531006
Agitation postoperative	20.06	14.06	6	74944	78	79669360
Blood triglycerides increased	20.03	14.06	54	74896	20986	79648452
Amaurosis	20.00	14.06	13	74937	1178	79668260
Congestive hepatopathy	19.99	14.06	23	74927	4524	79664914
Hyperdynamic left ventricle	19.89	14.06	9	74941	394	79669044
Potentiating drug interaction	19.52	14.06	32	74918	8787	79660651
Chronic kidney disease	19.50	14.06	20	74930	66134	79603304
Fear of death	19.42	14.06	14	74936	1502	79667936
Euthyroid sick syndrome	19.27	14.06	6	74944	90	79669348
Transurethral resection syndrome	19.18	14.06	4	74946	9	79669429
Blood catecholamines increased	19.13	14.06	5	74945	38	79669400
Electrocardiogram abnormal	19.10	14.06	46	74904	16691	79652747
Joint range of motion decreased	19.06	14.06	4	74946	33278	79636160
Hypoglycaemia	19.01	14.06	42	74908	101552	79567886
Acute respiratory failure	18.99	14.06	108	74842	59433	79610005
Conversion disorder	18.98	14.06	15	74935	1846	79667592
Fat embolism	18.98	14.06	9	74941	439	79668999
Histamine level increased	18.80	14.06	6	74944	98	79669340
Device programming error	18.65	14.06	7	74943	189	79669249
Haematuria traumatic	18.61	14.06	7	74943	190	79669248
Electrocardiogram T wave inversion	18.46	14.06	24	74926	5348	79664090
Chills	18.46	14.06	231	74719	160003	79509435
Electrocardiogram repolarisation abnormality	18.39	14.06	16	74934	2251	79667187
Road traffic accident	18.39	14.06	9	74941	43655	79625783
Phaeochromocytoma	18.32	14.06	10	74940	657	79668781
Colitis ulcerative	18.28	14.06	5	74945	34737	79634701
Myocardial ischaemia	18.10	14.06	59	74891	25460	79643978
Capillary nail refill test abnormal	18.10	14.06	5	74945	48	79669390
Frequent bowel movements	18.09	14.06	3	74947	29536	79639902
Limb injury	18.08	14.06	3	74947	29525	79639913
Bronchostenosis	17.99	14.06	10	74940	681	79668757
Tryptase	17.91	14.06	3	74947	0	79669438
Renal tubular necrosis	17.86	14.06	58	74892	24981	79644457
Lung consolidation	17.86	14.06	31	74919	8916	79660522
Supraventricular extrasystoles	17.74	14.06	27	74923	6960	79662478
Product quality issue	17.72	14.06	71	74879	33869	79635569
Acquired macroglossia	17.71	14.06	7	74943	218	79669220
Nerve stimulation test abnormal	17.66	14.06	4	74946	15	79669423
Postoperative respiratory distress	17.66	14.06	4	74946	15	79669423
Hyperpyrexia	17.58	14.06	25	74925	6067	79663371
Glossoptosis	17.53	14.06	7	74943	224	79669214
Bundle branch block right	17.47	14.06	35	74915	11216	79658222
Red blood cell count decreased	17.40	14.06	17	74933	57496	79611942
Rectal haemorrhage	17.39	14.06	28	74922	76272	79593166
Neurological decompensation	17.33	14.06	23	74927	5230	79664208
Bradycardia foetal	17.31	14.06	6	74944	128	79669310
Laryngeal obstruction	17.27	14.06	6	74944	129	79669309
Pulmonary fibrosis	17.25	14.06	10	74940	44102	79625336
Idiopathic interstitial pneumonia	17.22	14.06	7	74943	235	79669203
Neuralgia	17.20	14.06	5	74945	33379	79636059
Nephrogenic diabetes insipidus	17.19	14.06	15	74935	2119	79667319
Ileus	17.17	14.06	59	74891	26152	79643286
Pancreatitis acute	17.17	14.06	92	74858	49512	79619926
Completed suicide	17.15	14.06	148	74802	245619	79423819
Prostate cancer	17.11	14.06	5	74945	33263	79636175
Acute myeloid leukaemia	17.10	14.06	4	74946	30881	79638557
Euthanasia	17.09	14.06	6	74944	133	79669305
Metastases to liver	17.07	14.06	3	74947	28311	79641127
Oedema	16.71	14.06	57	74893	119523	79549915
Tonic convulsion	16.68	14.06	15	74935	2205	79667233
Ventricular tachyarrhythmia	16.65	14.06	8	74942	402	79669036
Injection site swelling	16.63	14.06	12	74938	47120	79622318
Myotonic dystrophy	16.61	14.06	6	74944	145	79669293
Feeling hot	16.57	14.06	19	74931	59715	79609723
Hypertensive crisis	16.55	14.06	50	74900	20720	79648718
Malabsorption	16.55	14.06	22	74928	5010	79664428
Intentional self-injury	16.44	14.06	5	74945	32414	79637024
Retrograde amnesia	16.43	14.06	9	74941	596	79668842
Scoliosis	16.41	14.06	27	74923	7437	79662001
Eczema	16.32	14.06	9	74941	40809	79628629
Foetal heart rate decreased	16.27	14.06	4	74946	23	79669415
Therapeutic product effect decreased	16.23	14.06	89	74861	163774	79505664
Cytomegalovirus infection	16.20	14.06	10	74940	42634	79626804
Sputum retention	16.07	14.06	11	74939	1086	79668352
Gastroenteritis	15.99	14.06	6	74944	34076	79635362
Extubation	15.98	14.06	4	74946	25	79669413
Ammonia increased	15.96	14.06	27	74923	7608	79661830
Rash morbilliform	15.95	14.06	24	74926	6126	79663312
Abdominal pain lower	15.94	14.06	5	74945	31777	79637661
Neisseria infection	15.78	14.06	6	74944	168	79669270
Influenza like illness	15.71	14.06	27	74923	71680	79597758
Myocardial infarction	15.62	14.06	105	74845	184024	79485414
COVID-19 treatment	15.61	14.06	8	74942	462	79668976
Bone marrow failure	15.58	14.06	15	74935	51092	79618346
Uterine atony	15.45	14.06	6	74944	178	79669260
Eye pain	15.44	14.06	8	74942	37570	79631868
Muscle necrosis	15.41	14.06	12	74938	1446	79667992
Hypovolaemic shock	15.38	14.06	35	74915	12241	79657197
Light anaesthesia	15.37	14.06	3	74947	4	79669434
Central-alveolar hypoventilation	15.35	14.06	4	74946	30	79669408
Grimacing	15.31	14.06	9	74941	682	79668756
Multiple use of single-use product	15.31	14.06	10	74940	914	79668524
Pollakiuria	15.25	14.06	8	74942	37309	79632129
Arrhythmia supraventricular	15.25	14.06	14	74936	2113	79667325
Eyelid function disorder	15.19	14.06	7	74943	320	79669118
Decerebrate posture	15.09	14.06	6	74944	190	79669248
Documented hypersensitivity to administered product	15.08	14.06	10	74940	937	79668501
Toxicity to various agents	15.06	14.06	510	74440	421030	79248408
Dermatitis bullous	15.03	14.06	38	74912	14207	79655231
Weaning failure	15.03	14.06	9	74941	706	79668732
Product use in unapproved indication	14.99	14.06	324	74626	250035	79419403
Paraplegia	14.97	14.06	21	74929	5032	79664406
Somatosensory evoked potentials abnormal	14.97	14.06	6	74944	194	79669244
Iron deficiency anaemia	14.88	14.06	3	74947	25669	79643769
Compartment syndrome	14.88	14.06	21	74929	5061	79664377
Hemiplegic migraine	14.87	14.06	5	74945	97	79669341
Myocardial stunning	14.82	14.06	6	74944	199	79669239
Quadriplegia	14.78	14.06	17	74933	3343	79666095
Injection site haemorrhage	14.68	14.06	4	74946	27866	79641572
Lung neoplasm malignant	14.62	14.06	4	74946	27788	79641650
Blood pressure increased	14.43	14.06	128	74822	211232	79458206
Lipoedema	14.36	14.06	6	74944	216	79669222
Hypertonia	14.36	14.06	25	74925	7207	79662231
Dysuria	14.35	14.06	16	74934	50935	79618503
Lymphangiectasia	14.32	14.06	5	74945	109	79669329
Hypophagia	14.20	14.06	13	74937	45354	79624084
Acne	14.14	14.06	4	74946	27186	79642252
Posturing	14.12	14.06	10	74940	1043	79668395

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N01AX10	NERVOUS SYSTEM ANESTHETICS ANESTHETICS, GENERAL Other general anesthetics
FDA EPC	N0000175681	General Anesthetic
FDA PE	N0000175975	General Anesthesia
CHEBI has role	CHEBI:35623	anticonvulsants
CHEBI has role	CHEBI:35717	hypnotics
CHEBI has role	CHEBI:38877	intravenous anesthetics
CHEBI has role	CHEBI:48578	free radical scavengers
CHEBI has role	CHEBI:50919	antiemetico
MeSH PA	D000777	Anesthetics
MeSH PA	D018686	Anesthetics, Intravenous
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D006993	Hypnotics and Sedatives

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
General anesthesia	indication	50697003
Sedation in Intubated Patients	indication
Sedation as Adjunct to Anesthesia	indication
Apnea	contraindication	1023001
Asthenia	contraindication	13791008
Hypovolemia	contraindication	28560003
Low blood pressure	contraindication	45007003
Cerebral arteriosclerosis	contraindication	65312002
Decreased respiratory function	contraindication	80954004
Epilepsy	contraindication	84757009	DOID:1826
Myocardial dysfunction	contraindication	233928007
Disorder of lipid metabolism	contraindication	267431006
Hypoxia	contraindication	389086002

🐶 Veterinary Drug Use

Species	Use	Relation
Cats	Anesthesia	Indication
Cats	General anesthesia for short procedures	Indication
Cats	Induction and maintenance of general anesthesia	Indication
Cats	General anesthesia	Indication
Dogs	Anesthesia	Indication
Dogs	General anesthesia for short procedures	Indication
Dogs	Induction and maintenance of general anesthesia	Indication
Dogs	General anesthesia	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Rapanofal	iVaoes Animal Health	1
PropoFlo, PropoFlo 28	Zoetis Inc.	1
PropoClear	Zoetis Inc.	1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.8	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
GABA-A receptor alpha-1/beta-2/gamma-2	Ion channel	P14867 P18507 P47870	GBRA1_HUMAN GBRG2_HUMAN GBRB2_HUMAN	POSITIVE ALLOSTERIC MODULATOR	EC50	5.70	CHEMBL	CHEMBL
GABA A receptor alpha-2/beta-2/gamma-2	Ion channel	P18507 P47869 P47870	GBRG2_HUMAN GBRA2_HUMAN GBRB2_HUMAN	POSITIVE ALLOSTERIC MODULATOR	EC50	4.95	CHEMBL	CHEMBL
GABA-A receptor alpha-1/beta-3/gamma-2	Ion channel	P14867 P18507 P28472	GBRA1_HUMAN GBRG2_HUMAN GBRB3_HUMAN	POSITIVE ALLOSTERIC MODULATOR	EC50	5.39	CHEMBL	CHEMBL
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	5.46	DRUG MATRIX
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN		Ki	5.22	DRUG MATRIX
Carbonic anhydrase 2	Enzyme	P00918	CAH2_HUMAN		IC50	4.01	WOMBAT-PK
Carbonic anhydrase 1	Enzyme	P00915	CAH1_HUMAN		IC50	4.71	WOMBAT-PK
Cytochrome P450 2C9	Enzyme	P11712	CP2C9_HUMAN		IC50	4.91	WOMBAT-PK
Transient receptor potential cation channel subfamily V member 4	Ion channel	Q9HBA0	TRPV4_HUMAN	INHIBITOR	IC50	4.41	IUPHAR
Fatty-acid amide hydrolase 1	Enzyme	O00519	FAAH1_HUMAN		IC50	4.28	WOMBAT-PK
Transient receptor potential cation channel subfamily V member 4	Ion channel	Q9HBA0	TRPV4_HUMAN	INHIBITOR	IC50	4.41	IUPHAR
Prostaglandin G/H synthase 1	Enzyme	P23219	PGH1_HUMAN		IC50	5.42	DRUG MATRIX
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN		Ki	5.03	DRUG MATRIX
Arachidonate 15-lipoxygenase	Enzyme		LOX15_RABIT		IC50	5.12	DRUG MATRIX
Fatty-acid amide hydrolase 1	Enzyme		FAAH1_RAT		IC50	4.85	CHEMBL
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1	Ion channel		HCN1_MOUSE	BLOCKER	IC50	5.20	IUPHAR
GABA-A receptor; anion channel	Ion channel		GBRP_RAT GBRB1_RAT GBRD_RAT GBRG2_RAT GBRA5_RAT GBRA3_RAT GBRG1_RAT GBRA2_RAT GBRA4_RAT GBRG3_RAT GBRA6_RAT GBRA1_RAT GBRB3_RAT GBRB2_RAT Q91ZM7_RAT GBRE_RAT		IC50	5.40	CHEMBL

External reference:

ID	Source
4019500	VUID
N0000147620	NUI
D00549	KEGG_DRUG
4019500	VANDF
C0033487	UMLSCUI
CHEBI:44915	CHEBI
PFL	PDB_CHEM_ID
CHEMBL526	ChEMBL_ID
DB00818	DRUGBANK_ID
D015742	MESH_DESCRIPTOR_UI
4943	PUBCHEM_CID
5073	INN_ID
5464	IUPHAR_LIGAND_ID
YI7VU623SF	UNII
196459	RXNORM
14179	MMSL
5372	MMSL
65	MMSL
d00933	MMSL
003528	NDDF
387423006	SNOMEDCT_US
74674007	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Propofol	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0209	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	36 sections
Propofol	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0209	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	36 sections
Propofol	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0234	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	36 sections
Propofol	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0234	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	36 sections
Propofol	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0248	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	36 sections
Propofol	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0248	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	36 sections
Propofol Lipuro	HUMAN PRESCRIPTION DRUG LABEL	1	0264-4850	INJECTION, EMULSION	10 mg	INTRAVENOUS	unapproved drug other	3 sections
PROPOFOL	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9943	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	14 sections
PROPOFOL	HUMAN PRESCRIPTION DRUG LABEL	1	0409-4699	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	34 sections
PROPOFOL	HUMAN PRESCRIPTION DRUG LABEL	1	0409-4699	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	34 sections
PROPOFOL	HUMAN PRESCRIPTION DRUG LABEL	1	0409-4699	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	34 sections
PROPOFOL	HUMAN PRESCRIPTION DRUG LABEL	1	0409-6010	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	34 sections
PROPOFOL	HUMAN PRESCRIPTION DRUG LABEL	1	0409-6010	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	34 sections
Propofol	HUMAN PRESCRIPTION DRUG LABEL	1	0591-2136	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	31 sections
Propofol	HUMAN PRESCRIPTION DRUG LABEL	1	0591-2136	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	31 sections
Propofol	HUMAN PRESCRIPTION DRUG LABEL	1	0591-2136	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	31 sections
Propofol	HUMAN PRESCRIPTION DRUG LABEL	1	0641-6194	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	32 sections
Propofol	HUMAN PRESCRIPTION DRUG LABEL	1	0641-6194	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	32 sections
Propofol	HUMAN PRESCRIPTION DRUG LABEL	1	0641-6195	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	32 sections
Propofol	HUMAN PRESCRIPTION DRUG LABEL	1	0641-6195	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	32 sections
Propofol	HUMAN PRESCRIPTION DRUG LABEL	1	0641-6196	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	32 sections
Propofol	HUMAN PRESCRIPTION DRUG LABEL	1	0641-6196	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	32 sections
propofol	HUMAN PRESCRIPTION DRUG LABEL	1	16714-528	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	26 sections
propofol	HUMAN PRESCRIPTION DRUG LABEL	1	16714-690	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	26 sections
propofol	HUMAN PRESCRIPTION DRUG LABEL	1	16714-977	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	26 sections
Fresenius Propoven 2%	HUMAN PRESCRIPTION DRUG LABEL	1	18124-027	EMULSION	20 mg	INTRAVENOUS	unapproved drug other	2 sections
propofol	HUMAN PRESCRIPTION DRUG LABEL	1	23155-345	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	32 sections
propofol	HUMAN PRESCRIPTION DRUG LABEL	1	23155-345	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	32 sections
propofol	HUMAN PRESCRIPTION DRUG LABEL	1	23155-345	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	32 sections
propofol	HUMAN PRESCRIPTION DRUG LABEL	1	25021-608	INJECTION, EMULSION	10 mg	INTRAVENOUS	ANDA	36 sections