propofol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2302 2078-54-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • propofol
  • ampofol
  • diprivan
  • disoprofol
  • pofol
An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
  • Molecular weight: 178.28
  • Formula: C12H18O
  • CLOGP: 3.93
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: -3.05
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.16 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 14.02 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 4.70 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 36 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.20 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Oct. 2, 1989 FDA FRESENIUS KABI USA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaphylactic shock 2370.95 15.32 782 35070 19373 50549899
Anaphylactic reaction 1025.03 15.32 575 35277 53480 50515792
Hypotension 757.43 15.32 880 34972 234589 50334683
Bronchospasm 736.96 15.32 306 35546 14548 50554724
Cardiac arrest 715.67 15.32 540 35312 83111 50486161
Propofol infusion syndrome 688.51 15.32 149 35703 617 50568655
Circulatory collapse 387.17 15.32 216 35636 19784 50549488
Serotonin syndrome 377.90 15.32 229 35623 24484 50544788
Delayed recovery from anaesthesia 372.66 15.32 90 35762 659 50568613
Tachycardia 369.02 15.32 402 35450 99361 50469911
Stress cardiomyopathy 339.54 15.32 147 35705 7740 50561532
Bradycardia 313.32 15.32 301 35551 64125 50505147
Hyperthermia malignant 307.91 15.32 77 35775 662 50568610
Respiratory depression 274.94 15.32 145 35707 11865 50557407
Fatigue 271.51 15.32 83 35769 707518 49861754
Status epilepticus 257.25 15.32 144 35708 13262 50556010
Ventricular tachycardia 242.81 15.32 147 35705 15674 50553598
Drug interaction 238.61 15.32 471 35381 199150 50370122
Neuromuscular block prolonged 231.78 15.32 57 35795 454 50568818
Arthralgia 229.08 15.32 23 35829 438679 50130593
Multiple organ dysfunction syndrome 212.80 15.32 218 35634 50119 50519153
Ventricular fibrillation 212.38 15.32 117 35735 10442 50558830
Shock 200.16 15.32 144 35708 20506 50548766
Oxygen saturation decreased 193.93 15.32 249 35603 72999 50496273
Diarrhoea 193.55 15.32 88 35764 588388 49980884
Metabolic acidosis 185.97 15.32 180 35672 38645 50530627
Blood pressure decreased 185.34 15.32 213 35639 55696 50513576
Haemodynamic instability 172.71 15.32 93 35759 7931 50561341
Procedural hypotension 167.15 15.32 52 35800 1050 50568222
Pulseless electrical activity 163.41 15.32 85 35767 6756 50562516
Apnoea 161.96 15.32 85 35767 6881 50562391
Anaesthetic complication 159.29 15.32 56 35796 1674 50567598
Joint swelling 155.09 15.32 4 35848 245282 50323990
Unwanted awareness during anaesthesia 150.82 15.32 36 35816 249 50569023
Dystonia 148.30 15.32 97 35755 11829 50557443
Fall 143.79 15.32 31 35821 334901 50234371
Myoclonus 142.72 15.32 102 35750 14368 50554904
Diabetes insipidus 138.75 15.32 55 35797 2309 50566963
Alopecia 138.35 15.32 9 35843 245038 50324234
Anaphylactoid shock 136.81 15.32 34 35818 284 50568988
Drug intolerance 133.37 15.32 5 35847 219099 50350173
Rhabdomyolysis 133.21 15.32 151 35701 38876 50530396
Hypoxia 130.88 15.32 171 35681 50952 50518320
Post procedural complication 127.63 15.32 97 35755 15007 50554265
Labile blood pressure 127.54 15.32 47 35805 1613 50567659
Generalised tonic-clonic seizure 120.39 15.32 119 35733 26191 50543081
Airway complication of anaesthesia 118.68 15.32 28 35824 183 50569089
Headache 118.48 15.32 111 35741 506424 50062848
Procedural complication 118.27 15.32 61 35791 4762 50564510
Electrocardiogram ST segment elevation 115.28 15.32 54 35798 3419 50565853
Abdominal discomfort 113.53 15.32 15 35837 231626 50337646
Blood creatine phosphokinase increased 112.82 15.32 115 35737 26252 50543020
Nasopharyngitis 112.17 15.32 6 35846 192921 50376351
Rheumatoid arthritis 109.83 15.32 9 35843 202541 50366731
Laryngospasm 108.83 15.32 48 35804 2640 50566632
Respiratory acidosis 108.19 15.32 62 35790 5966 50563306
Pain 107.20 15.32 153 35699 578750 49990522
Anaphylactoid reaction 104.00 15.32 50 35802 3356 50565916
Cardio-respiratory arrest 103.36 15.32 157 35695 53735 50515537
Myoglobin urine present 101.60 15.32 28 35824 362 50568910
Hypoventilation 100.23 15.32 51 35801 3870 50565402
Torsade de pointes 99.98 15.32 76 35776 11759 50557513
Malaise 99.77 15.32 57 35795 335475 50233797
Pain in extremity 98.85 15.32 35 35817 272830 50296442
Cardiogenic shock 95.48 15.32 83 35769 15516 50553756
Unresponsive to stimuli 95.34 15.32 113 35739 30496 50538776
Product dose omission issue 94.78 15.32 10 35842 183828 50385444
Sinusitis 94.08 15.32 7 35845 170551 50398721
Peripheral swelling 92.59 15.32 17 35835 205919 50363353
Respiratory failure 92.02 15.32 201 35651 90980 50478292
Clonus 91.55 15.32 49 35803 4126 50565146
Type I hypersensitivity 91.46 15.32 41 35811 2344 50566928
Tryptase increased 91.42 15.32 23 35829 203 50569069
Arthropathy 88.47 15.32 6 35846 157900 50411372
Nausea 86.91 15.32 237 35615 705161 49864111
Arteriospasm coronary 86.23 15.32 44 35808 3358 50565914
Anticholinergic syndrome 85.64 15.32 36 35816 1759 50567513
Dizziness 85.53 15.32 72 35780 346297 50222975
Weight increased 83.90 15.32 20 35832 201871 50367401
PCO2 increased 82.82 15.32 31 35821 1112 50568160
Product contamination 82.70 15.32 26 35826 544 50568728
Mydriasis 82.69 15.32 65 35787 10562 50558710
Anaesthetic complication pulmonary 81.85 15.32 16 35836 34 50569238
Systemic lupus erythematosus 79.79 15.32 5 35847 140617 50428655
Respiratory arrest 79.30 15.32 102 35750 29907 50539365
Intestinal ischaemia 79.25 15.32 53 35799 6704 50562568
Opisthotonus 78.28 15.32 22 35830 307 50568965
Renal ischaemia 78.04 15.32 25 35827 557 50568715
Weight decreased 77.37 15.32 30 35822 221215 50348057
Ventricular hypokinesia 77.00 15.32 43 35809 3937 50565335
Transmission of an infectious agent via product 75.22 15.32 18 35834 126 50569146
Oliguria 74.38 15.32 55 35797 8161 50561111
Dyspnoea 73.48 15.32 176 35676 547432 50021840
Intra-abdominal pressure increased 72.51 15.32 19 35833 200 50569072
Swelling 72.30 15.32 26 35826 200846 50368426
Infusion related reaction 72.02 15.32 16 35836 169541 50399731
Disseminated intravascular coagulation 70.15 15.32 73 35779 17062 50552210
Encephalopathy 70.05 15.32 102 35750 33609 50535663
Mitochondrial DNA mutation 70.01 15.32 19 35833 231 50569041
Laryngeal oedema 69.99 15.32 44 35808 5009 50564263
Hepatic ischaemia 69.04 15.32 23 35829 582 50568690
Pulmonary oedema 68.81 15.32 124 35728 48814 50520458
Contraindicated product administered 67.57 15.32 12 35840 148946 50420326
Insomnia 67.56 15.32 20 35832 174845 50394427
Multiple-drug resistance 67.39 15.32 37 35815 3277 50565995
Exposure during pregnancy 66.80 15.32 213 35639 120802 50448470
Pruritus 66.28 15.32 62 35790 283506 50285766
Brain oedema 66.16 15.32 61 35791 12309 50556963
Stridor 66.15 15.32 36 35816 3133 50566139
Vasoplegia syndrome 65.66 15.32 26 35826 1088 50568184
Pneumatosis 63.95 15.32 20 35832 411 50568861
Blood gases abnormal 63.90 15.32 22 35830 617 50568655
PO2 increased 62.14 15.32 23 35829 799 50568473
Constipation 61.96 15.32 27 35825 185681 50383591
Seizure 61.02 15.32 203 35649 117671 50451601
Acute respiratory distress syndrome 60.97 15.32 75 35777 21024 50548248
Drug ineffective for unapproved indication 60.45 15.32 75 35777 21206 50548066
Blood pH decreased 60.05 15.32 31 35821 2424 50566848
Electrocardiogram QT prolonged 60.02 15.32 121 35731 51765 50517507
Agitation 59.98 15.32 123 35729 53261 50516011
Hyperreflexia 59.68 15.32 40 35812 5078 50564194
Oculogyric crisis 59.27 15.32 26 35826 1411 50567861
Premature delivery 58.74 15.32 78 35774 23585 50545687
Decreased appetite 58.41 15.32 35 35817 200888 50368384
Neuromuscular blockade 58.28 15.32 17 35835 273 50568999
Hepatorenal syndrome 57.54 15.32 27 35825 1716 50567556
Amylase increased 57.53 15.32 40 35812 5390 50563882
Dyskinesia 57.45 15.32 84 35768 27777 50541495
Coagulopathy 57.11 15.32 67 35785 17877 50551395
Erythema 57.10 15.32 230 35622 146184 50423088
Endotracheal intubation complication 56.88 15.32 18 35834 385 50568887
Septic shock 56.46 15.32 125 35727 57050 50512222
Anaesthetic complication neurological 56.32 15.32 15 35837 169 50569103
Sinus tachycardia 55.50 15.32 72 35780 21282 50547990
Lower respiratory tract infection 55.17 15.32 3 35849 95198 50474074
End-tidal CO2 decreased 54.66 15.32 10 35842 12 50569260
Oxygen saturation abnormal 54.48 15.32 30 35822 2672 50566600
Muscle rigidity 53.59 15.32 49 35803 9780 50559492
Electrocardiogram QRS complex prolonged 53.44 15.32 38 35814 5306 50563966
Contusion 53.18 15.32 8 35844 112175 50457097
Discomfort 53.09 15.32 7 35845 108373 50460899
Renal impairment 53.01 15.32 145 35707 75516 50493756
Carcinoid crisis 52.94 15.32 15 35837 216 50569056
Musculoskeletal stiffness 52.81 15.32 13 35839 128468 50440804
Bronchitis 52.80 15.32 6 35846 104153 50465119
Ventricular extrasystoles 52.66 15.32 50 35802 10466 50558806
Atrioventricular block complete 51.39 15.32 42 35810 7213 50562059
Foetal death 51.01 15.32 44 35808 8136 50561136
Postoperative delirium 50.92 15.32 12 35840 78 50569194
Upper airway obstruction 50.66 15.32 18 35834 555 50568717
Hepatocellular injury 50.30 15.32 76 35776 25871 50543401
Toxic encephalopathy 50.10 15.32 37 35815 5478 50563794
Arthritis 49.43 15.32 3 35849 86718 50482554
Wound 49.12 15.32 8 35844 105786 50463486
Therapeutic product effect prolonged 48.44 15.32 15 35837 298 50568974
Influenza 48.43 15.32 4 35848 89534 50479738
Necrosis ischaemic 48.33 15.32 19 35833 780 50568492
Acute generalised exanthematous pustulosis 47.65 15.32 44 35808 8894 50560378
Acute pulmonary oedema 47.17 15.32 40 35812 7227 50562045
Post procedural haemorrhage 47.16 15.32 40 35812 7230 50562042
Gastrointestinal disorder 46.50 15.32 6 35846 94450 50474822
Stomatitis 46.30 15.32 8 35844 101336 50467936
Shock haemorrhagic 46.28 15.32 42 35810 8302 50560970
Gene mutation 46.04 15.32 21 35831 1250 50568022
Pneumonia 45.73 15.32 128 35724 378273 50190999
Unmasking of previously unidentified disease 45.30 15.32 18 35834 760 50568512
Death 44.77 15.32 103 35749 325276 50243996
Posterior reversible encephalopathy syndrome 44.64 15.32 54 35798 14874 50554398
Urinary tract infection 44.52 15.32 56 35796 223964 50345308
Acute hepatic failure 44.12 15.32 55 35797 15622 50553650
Fear 44.12 15.32 53 35799 14496 50554776
Gait disturbance 43.76 15.32 26 35826 149979 50419293
Angioedema 43.73 15.32 88 35764 37588 50531684
Hypovolaemia 43.63 15.32 43 35809 9422 50559850
Muscle relaxant therapy 42.93 15.32 12 35840 164 50569108
Back pain 42.69 15.32 56 35796 219974 50349298
Mental status changes postoperative 42.47 15.32 12 35840 171 50569101
Cardiovascular insufficiency 42.20 15.32 20 35832 1300 50567972
Perforation 41.58 15.32 18 35834 946 50568326
Troponin increased 41.42 15.32 39 35813 8079 50561193
Confusion postoperative 41.24 15.32 12 35840 191 50569081
Suspected product quality issue 41.12 15.32 12 35840 193 50569079
Blood bicarbonate decreased 40.97 15.32 25 35827 2700 50566572
Blood lactic acid increased 40.96 15.32 33 35819 5552 50563720
Pulse absent 40.89 15.32 31 35821 4775 50564497
Product contamination microbial 40.83 15.32 12 35840 198 50569074
Hepatic failure 40.61 15.32 78 35774 32205 50537067
Renal failure 40.34 15.32 166 35686 106467 50462805
Asthenia 39.97 15.32 106 35746 318936 50250336
Coma 39.83 15.32 109 35743 56770 50512502
Chest pain 39.74 15.32 40 35812 176842 50392430
Hypercapnia 39.71 15.32 30 35822 4597 50564675
Procedural nausea 39.60 15.32 16 35836 706 50568566
Alanine aminotransferase increased 39.49 15.32 145 35707 88214 50481058
Electrocardiogram ST segment depression 39.29 15.32 24 35828 2596 50566676
Acidosis hyperchloraemic 39.17 15.32 13 35839 325 50568947
Injection site pain 38.86 15.32 15 35837 111009 50458263
Hepatorenal failure 38.81 15.32 15 35837 588 50568684
Local anaesthetic systemic toxicity 38.59 15.32 15 35837 597 50568675
Hyperlactacidaemia 38.32 15.32 23 35829 2410 50566862
Hepatitis acute 38.25 15.32 37 35815 7924 50561348
Skin test positive 37.60 15.32 15 35837 640 50568632
Neuropathy peripheral 37.47 15.32 11 35841 96746 50472526
Neutropenia 37.37 15.32 30 35822 147935 50421337
Airway peak pressure increased 36.82 15.32 12 35840 283 50568989
Inappropriate schedule of product administration 36.75 15.32 4 35848 71827 50497445
Cardiac output decreased 36.20 15.32 16 35836 884 50568388
Delirium 36.02 15.32 82 35770 38110 50531162
Wrong product administered 35.81 15.32 30 35822 5330 50563942
Renal injury 35.81 15.32 37 35815 8574 50560698
Subcutaneous emphysema 35.51 15.32 15 35837 742 50568530
Altered state of consciousness 35.33 15.32 59 35793 21851 50547421
Electroencephalogram abnormal 35.26 15.32 25 35827 3474 50565798
Procedural vomiting 35.08 15.32 13 35839 453 50568819
Ultrasound ovary abnormal 35.04 15.32 9 35843 87 50569185
Psoriasis 34.90 15.32 4 35848 68996 50500276
Left ventricle outflow tract obstruction 34.86 15.32 11 35841 233 50569039
Hypocapnia 34.84 15.32 12 35840 337 50568935
Laryngeal stenosis 34.76 15.32 15 35837 782 50568490
Abdominal pain upper 34.68 15.32 37 35815 159272 50410000
Infection 34.59 15.32 43 35809 172911 50396361
Coma scale abnormal 34.59 15.32 28 35824 4743 50564529
Macroglossia 34.52 15.32 14 35838 624 50568648
Maternal exposure during delivery 34.50 15.32 16 35836 990 50568282
Atrioventricular block second degree 34.49 15.32 25 35827 3596 50565676
Toxic epidermal necrolysis 34.48 15.32 57 35795 20935 50548337
Arrhythmia 34.48 15.32 74 35778 33058 50536214
Malignant neoplasm progression 34.33 15.32 4 35848 68120 50501152
Oedema peripheral 34.04 15.32 37 35815 157924 50411348
Atrioventricular block first degree 33.98 15.32 31 35821 6170 50563102
Paralysis 33.83 15.32 36 35816 8628 50560644
Oropharyngeal pain 33.71 15.32 7 35845 77794 50491478
Herpes zoster 33.65 15.32 5 35847 70781 50498491
Procedural haemorrhage 33.57 15.32 21 35831 2369 50566903
Blood lactate dehydrogenase increased 33.32 15.32 54 35798 19508 50549764
Myxoedema coma 33.27 15.32 12 35840 387 50568885
Feeling abnormal 32.25 15.32 25 35827 125467 50443805
Hepatic enzyme increased 32.09 15.32 30 35822 137350 50431922
Sinus bradycardia 32.01 15.32 43 35809 13140 50556132
Injection site erythema 31.94 15.32 7 35845 74929 50494343
Myoclonic epilepsy 31.86 15.32 15 35837 960 50568312
Disease progression 31.85 15.32 14 35838 95852 50473420
Extravasation 31.73 15.32 19 35833 1983 50567289
Cyanosis 31.62 15.32 46 35806 15138 50554134
Left ventricular dysfunction 31.41 15.32 38 35814 10468 50558804
Hepatitis 31.30 15.32 69 35783 31384 50537888
Hypertriglyceridaemia 31.16 15.32 28 35824 5463 50563809
Muscle twitching 31.05 15.32 46 35806 15385 50553887
Brain death 30.66 15.32 21 35831 2762 50566510
Gaze palsy 30.23 15.32 16 35836 1317 50567955
Blood pressure immeasurable 29.99 15.32 15 35837 1097 50568175
Myoglobinuria 29.83 15.32 10 35842 258 50569014
Neuroleptic malignant syndrome 29.66 15.32 38 35814 11092 50558180
Recurrence of neuromuscular blockade 29.65 15.32 8 35844 95 50569177
Procedural hypertension 29.44 15.32 10 35842 269 50569003
Ventricular dysfunction 29.40 15.32 20 35832 2601 50566671
Trigemino-cardiac reflex 29.38 15.32 7 35845 48 50569224
Acute kidney injury 29.35 15.32 268 35584 227790 50341482
Respiratory distress 29.35 15.32 66 35786 30423 50538849
Systemic inflammatory response syndrome 29.16 15.32 26 35826 5023 50564249
Aspartate aminotransferase increased 29.15 15.32 121 35731 77877 50491395
Loss of personal independence in daily activities 28.94 15.32 7 35845 70043 50499229
Vitamin K deficiency 28.93 15.32 11 35841 412 50568860
Somatosensory evoked potentials abnormal 28.92 15.32 5 35847 3 50569269
Eosinophilia 28.45 15.32 49 35803 18603 50550669
Supraventricular tachycardia 28.44 15.32 40 35812 12761 50556511
Acute postoperative sialadenitis 28.29 15.32 6 35846 22 50569250
Depression 28.25 15.32 46 35806 165377 50403895
Haemodilution 28.12 15.32 8 35844 117 50569155
Anhedonia 27.74 15.32 34 35818 9490 50559782
Premature baby 27.74 15.32 48 35804 18289 50550983
Abdominal pain 27.68 15.32 81 35771 236147 50333125
Atrioventricular dissociation 27.42 15.32 9 35843 217 50569055
Dehydration 27.36 15.32 41 35811 152408 50416864
Skin test negative 27.33 15.32 5 35847 6 50569266
Burkholderia test positive 26.89 15.32 9 35843 231 50569041
Myotonia 26.84 15.32 8 35844 139 50569133
Haematemesis 26.67 15.32 60 35792 27665 50541607
Hypovolaemic shock 26.61 15.32 25 35827 5163 50564109
Maternal exposure during pregnancy 26.57 15.32 199 35653 159579 50409693
Lactic acidosis 26.48 15.32 67 35785 33288 50535984
Oesophageal intramural haematoma 26.35 15.32 7 35845 78 50569194
Thyrotoxic crisis 25.91 15.32 12 35840 740 50568532
Lipoedema 25.76 15.32 9 35843 264 50569008
Ill-defined disorder 25.66 15.32 4 35848 54650 50514622
Gastrooesophageal reflux disease 25.64 15.32 11 35841 76417 50492855
Depressed level of consciousness 25.55 15.32 88 35764 51865 50517407
White blood cell count decreased 25.52 15.32 27 35825 116695 50452577
Hypotensive transfusion reaction 25.20 15.32 6 35846 41 50569231
Coronary artery embolism 25.20 15.32 8 35844 173 50569099
Abscess neck 25.11 15.32 11 35841 595 50568677
Hypoaesthesia 25.06 15.32 32 35820 127225 50442047
Tracheal injury 24.83 15.32 6 35846 44 50569228
Patent ductus arteriosus 24.74 15.32 21 35831 3799 50565473
Phrenic nerve paralysis 24.63 15.32 7 35845 102 50569170
Drug reaction with eosinophilia and systemic symptoms 24.58 15.32 59 35793 28365 50540907
Tachypnoea 24.50 15.32 40 35812 14537 50554735
Irregular breathing 24.47 15.32 9 35843 307 50568965
Dyspepsia 24.33 15.32 11 35841 74086 50495186
Hyperammonaemic encephalopathy 24.21 15.32 16 35836 1983 50567289
Hyperkalaemia 24.12 15.32 82 35770 48007 50521265
Anaesthetic complication cardiac 24.10 15.32 5 35847 16 50569256
Hospitalisation 24.06 15.32 9 35843 67928 50501344
Asthma 23.98 15.32 17 35835 89320 50479952
Bezold-Jarisch reflex 23.87 15.32 5 35847 17 50569255
Tracheal deviation 23.84 15.32 6 35846 53 50569219
Ischaemic cerebral infarction 23.79 15.32 13 35839 1140 50568132
Treatment failure 23.75 15.32 38 35814 137599 50431673
Intensive care unit acquired weakness 23.63 15.32 11 35841 686 50568586
Kounis syndrome 23.56 15.32 13 35839 1162 50568110
Impaired healing 23.48 15.32 10 35842 69776 50499496
Syncope 23.45 15.32 23 35829 102979 50466293
Nasal congestion 23.42 15.32 4 35848 51116 50518156
Air embolism 23.35 15.32 8 35844 221 50569051
Electrocardiogram repolarisation abnormality 23.31 15.32 13 35839 1187 50568085
Muscle spasms 23.27 15.32 33 35819 125520 50443752
Musculoskeletal pain 23.26 15.32 11 35841 72166 50497106
Anaemia 23.22 15.32 96 35756 252360 50316912
Chest discomfort 23.15 15.32 19 35833 92703 50476569
Endotracheal intubation 23.13 15.32 16 35836 2138 50567134
Inadequate aseptic technique in use of product 23.04 15.32 5 35847 21 50569251
Neck pain 23 15.32 6 35846 57061 50512211
Acidosis 22.79 15.32 32 35820 10195 50559077
Extubation 22.67 15.32 5 35847 23 50569249
Cough 22.65 15.32 91 35761 241173 50328099
Hypoxic-ischaemic encephalopathy 22.61 15.32 20 35832 3822 50565450
Toxicity to various agents 22.59 15.32 240 35612 212259 50357013
Suspected product contamination 22.33 15.32 5 35847 25 50569247
Hepatic cytolysis 22.12 15.32 28 35824 8075 50561197
Diabetes mellitus 22.11 15.32 4 35848 49029 50520243
Sepsis syndrome 22.02 15.32 11 35841 802 50568470
Stevens-Johnson syndrome 21.96 15.32 48 35804 21704 50547568
Product use issue 21.59 15.32 46 35806 149429 50419843
Cystitis 21.52 15.32 3 35849 44561 50524711
Acquired macroglossia 21.32 15.32 7 35845 169 50569103
Extrasystoles 21.18 15.32 21 35831 4634 50564638
Vision blurred 21.06 15.32 15 35837 78632 50490640
Eosinophilic pneumonia acute 20.98 15.32 8 35844 302 50568970
Accidental overdose 20.75 15.32 44 35808 19489 50549783
Haemoperitoneum 20.68 15.32 16 35836 2539 50566733
Tongue oedema 20.66 15.32 19 35833 3820 50565452
Post procedural fever 20.52 15.32 8 35844 321 50568951
Condition aggravated 20.44 15.32 125 35727 296933 50272339
Tidal volume decreased 20.42 15.32 5 35847 39 50569233
Intensive care unit delirium 20.31 15.32 5 35847 40 50569232
Atrioventricular block 20.30 15.32 24 35828 6454 50562818
Tonic clonic movements 20.28 15.32 12 35840 1225 50568047
Idiosyncratic drug reaction 20.26 15.32 10 35842 711 50568561
Hypothermia 20.23 15.32 33 35819 11983 50557289
Hepatitis C 20.21 15.32 21 35831 4896 50564376
Urticaria 20.21 15.32 159 35693 129402 50439870
Therapeutic product effect incomplete 20.19 15.32 21 35831 91494 50477778
Intentional product use issue 20.17 15.32 15 35837 76903 50492369
Emotional distress 20.12 15.32 55 35797 28608 50540664
Brain herniation 20.03 15.32 17 35835 3075 50566197
Laryngeal obstruction 19.83 15.32 6 35846 110 50569162
Upper respiratory tract infection 19.80 15.32 11 35841 65887 50503385
Rash maculo-papular 19.59 15.32 52 35800 26589 50542683
Balance disorder 19.52 15.32 13 35839 70577 50498695
Migraine 19.33 15.32 15 35837 75265 50494007
Cardiac massage 19.23 15.32 4 35848 13 50569259
Bradycardia foetal 19.18 15.32 8 35844 383 50568889
Hypernatraemia 19.12 15.32 23 35829 6298 50562974
Eyelid function disorder 19.11 15.32 7 35845 236 50569036
Chronic obstructive pulmonary disease 19.06 15.32 7 35845 53428 50515844
Dry mouth 18.98 15.32 8 35844 56170 50513102
Epilepsy 18.90 15.32 45 35807 21522 50547750
Transcranial electrical motor evoked potential monitoring abnormal 18.76 15.32 3 35849 0 50569272
Bispectral index decreased 18.76 15.32 3 35849 0 50569272
Face oedema 18.74 15.32 40 35812 17799 50551473
Mucosal inflammation 18.70 15.32 3 35849 40139 50529133
Partial seizures 18.62 15.32 20 35832 4845 50564427
Peripheral nerve palsy 18.59 15.32 4 35848 16 50569256
Long QT syndrome 18.58 15.32 16 35836 2951 50566321
Apnoeic attack 18.52 15.32 7 35845 258 50569014
Dry skin 18.47 15.32 4 35848 43187 50526085
Infantile apnoea 18.45 15.32 10 35842 863 50568409
Hepatic function abnormal 18.43 15.32 58 35794 32623 50536649
Tracheal haemorrhage 18.39 15.32 6 35846 142 50569130
Palpitations 18.36 15.32 24 35828 94482 50474790
Mean arterial pressure decreased 18.23 15.32 6 35846 146 50569126
Device programming error 18.12 15.32 5 35847 65 50569207
Mobility decreased 18.03 15.32 18 35834 79930 50489342
Rhinorrhoea 17.99 15.32 7 35845 51576 50517696
Respiratory rate decreased 17.94 15.32 16 35836 3092 50566180
Drug-induced liver injury 17.86 15.32 52 35800 28043 50541229
Euthyroid sick syndrome 17.84 15.32 5 35847 69 50569203
Abdominal sepsis 17.72 15.32 11 35841 1224 50568048
Ventricular asystole 17.65 15.32 5 35847 72 50569200
Obstructive airways disorder 17.49 15.32 36 35816 15616 50553656
Administration site extravasation 17.33 15.32 9 35843 712 50568560
Ammonia increased 17.23 15.32 18 35834 4223 50565049
Bone pain 17.16 15.32 6 35846 47223 50522049
Therapeutic product effect decreased 17.15 15.32 45 35807 136005 50433267
Ventricular arrhythmia 17.08 15.32 16 35836 3293 50565979
Overdose 17.01 15.32 125 35727 99602 50469670
Polyuria 16.94 15.32 23 35829 7098 50562174
Haemodialysis 16.93 15.32 25 35827 8337 50560935
Uterine atony 16.86 15.32 6 35846 186 50569086
Agitation postoperative 16.84 15.32 4 35848 27 50569245
Fat embolism 16.83 15.32 6 35846 187 50569085
Abdominal rigidity 16.77 15.32 12 35840 1692 50567580
Gait inability 16.74 15.32 3 35849 37024 50532248
Nerve stimulation test abnormal 16.68 15.32 3 35849 3 50569269
Blood magnesium decreased 16.60 15.32 29 35823 11131 50558141
Haematochezia 16.44 15.32 4 35848 39878 50529394
Chemical peritonitis 16.31 15.32 5 35847 96 50569176
Pulmonary alveolar haemorrhage 16.20 15.32 17 35835 4010 50565262
Burning sensation 16.13 15.32 6 35846 45440 50523832
Systolic dysfunction 15.96 15.32 11 35841 1461 50567811
Extensor plantar response 15.86 15.32 10 35842 1144 50568128
Hypomagnesaemia 15.83 15.32 44 35808 23112 50546160
Osteoporosis 15.80 15.32 6 35846 44873 50524399
Procedural dizziness 15.80 15.32 5 35847 107 50569165
Cardiotoxicity 15.67 15.32 22 35830 7005 50562267
Coronary artery bypass 15.66 15.32 13 35839 2280 50566992
Suicidal ideation 15.58 15.32 10 35842 55375 50513897
Hyperthermia 15.56 15.32 23 35829 7673 50561599
Blood bilirubin increased 15.51 15.32 54 35798 31984 50537288
Extrapyramidal disorder 15.49 15.32 29 35823 11741 50557531
Central-alveolar hypoventilation 15.47 15.32 3 35849 6 50569266
Spinal cord disorder 15.45 15.32 10 35842 1197 50568075
Intracranial pressure increased 15.43 15.32 17 35835 4235 50565037

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaphylactic shock 1559.94 16.07 587 34183 12749 29527008
Propofol infusion syndrome 1134.20 16.07 248 34522 559 29539198
Anaphylactic reaction 752.88 16.07 444 34326 27129 29512628
Hyperthermia malignant 575.27 16.07 169 34601 1615 29538142
Hypotension 504.78 16.07 853 33917 193501 29346256
Cardiac arrest 494.59 16.07 554 34216 85037 29454720
Bradycardia 389.40 16.07 431 34339 65198 29474559
Bronchospasm 386.57 16.07 200 34570 9409 29530348
Delayed recovery from anaesthesia 312.00 16.07 86 34684 637 29539120
Rhabdomyolysis 299.54 16.07 363 34407 60445 29479312
Serotonin syndrome 268.96 16.07 197 34573 17315 29522442
Fatigue 240.40 16.07 42 34728 316779 29222978
Anaesthetic complication 222.39 16.07 71 34699 915 29538842
Tachycardia 215.50 16.07 339 34431 72071 29467686
Circulatory collapse 214.74 16.07 177 34593 18496 29521261
Metabolic acidosis 190.42 16.07 228 34542 37434 29502323
Neuromuscular block prolonged 167.59 16.07 48 34722 415 29539342
Pulseless electrical activity 163.28 16.07 99 34671 6335 29533422
Ventricular fibrillation 157.28 16.07 138 34632 15695 29524062
Diarrhoea 151.91 16.07 103 34667 332595 29207162
Haemodynamic instability 147.45 16.07 101 34669 7972 29531785
Oxygen saturation decreased 137.16 16.07 213 34557 44724 29495033
Shock 134.31 16.07 145 34625 21259 29518498
Electrocardiogram ST segment elevation 132.01 16.07 76 34694 4416 29535341
Status epilepticus 127.58 16.07 104 34666 10690 29529067
Blood pressure decreased 125.66 16.07 206 34564 45271 29494486
Myoclonus 122.26 16.07 111 34659 13198 29526559
Fall 120.63 16.07 30 34740 177148 29362609
Death 118.66 16.07 137 34633 341947 29197810
Respiratory depression 116.86 16.07 109 34661 13414 29526343
Intensive care unit acquired weakness 115.43 16.07 43 34727 900 29538857
Arthralgia 113.58 16.07 15 34755 139602 29400155
Airway complication of anaesthesia 108.85 16.07 27 34743 124 29539633
Decreased appetite 102.07 16.07 23 34747 145319 29394438
Drug interaction 101.81 16.07 480 34290 196905 29342852
Ventricular tachycardia 100.08 16.07 128 34642 22446 29517311
Injury 98.98 16.07 117 34653 18929 29520828
Hypoxic-ischaemic encephalopathy 98.73 16.07 62 34708 4222 29535535
Post procedural complication 96.10 16.07 87 34683 10302 29529455
Diabetes insipidus 93.07 16.07 49 34721 2385 29537372
Hypoxia 90.61 16.07 183 34587 47196 29492561
Toxic epidermal necrolysis 90.20 16.07 109 34661 18044 29521713
Dizziness 88.65 16.07 57 34713 189627 29350130
Drug reaction with eosinophilia and systemic symptoms 88.61 16.07 135 34635 27857 29511900
Multiple organ dysfunction syndrome 87.15 16.07 214 34556 62902 29476855
Product dose omission issue 86.99 16.07 7 34763 96376 29443381
Laryngospasm 85.94 16.07 38 34732 1252 29538505
Hypertriglyceridaemia 84.10 16.07 70 34700 7405 29532352
Procedural complication 81.81 16.07 54 34716 4006 29535751
Blood creatine phosphokinase increased 81.32 16.07 160 34610 40484 29499273
Respiratory acidosis 81.05 16.07 55 34715 4273 29535484
Anaphylactoid shock 80.80 16.07 26 34744 344 29539413
Trigemino-cardiac reflex 80.51 16.07 22 34748 157 29539600
Negative pressure pulmonary oedema 80.18 16.07 23 34747 200 29539557
Asthenia 76.84 16.07 84 34686 215166 29324591
Anaesthetic complication neurological 75.75 16.07 24 34746 301 29539456
Tachypnoea 75.48 16.07 91 34679 15024 29524733
Arteriospasm coronary 74.31 16.07 43 34727 2522 29537235
Headache 73.78 16.07 58 34712 173949 29365808
Fear 73.37 16.07 72 34698 9432 29530325
Pain in extremity 72.60 16.07 20 34750 110413 29429344
Procedural hypotension 71.74 16.07 30 34740 860 29538897
Pulse absent 70.59 16.07 54 34716 5059 29534698
Intestinal ischaemia 69.80 16.07 60 34710 6632 29533125
Nausea 68.64 16.07 149 34621 289106 29250651
Apnoea 66.28 16.07 56 34714 6046 29533711
Respiratory arrest 65.94 16.07 113 34657 25720 29514037
Stress cardiomyopathy 65.83 16.07 34 34736 1590 29538167
Vasoplegia syndrome 65.28 16.07 33 34737 1475 29538282
Malaise 64.18 16.07 56 34714 159546 29380211
Autonomic nervous system imbalance 64.00 16.07 38 34732 2338 29537419
Renal injury 63.77 16.07 69 34701 10133 29529624
Transmission of an infectious agent via product 62.30 16.07 18 34752 161 29539596
Kounis syndrome 62.03 16.07 34 34736 1795 29537962
Spinal muscular atrophy 61.99 16.07 20 34750 267 29539490
Anaemia 61.67 16.07 88 34682 200863 29338894
Abdominal pain 61.39 16.07 42 34728 135315 29404442
Seizure like phenomena 60.38 16.07 24 34746 602 29539155
Agitation 59.51 16.07 163 34607 51141 29488616
Weight decreased 59.40 16.07 54 34716 150851 29388906
Drug level changed 58.83 16.07 20 34750 317 29539440
Brain oedema 58.46 16.07 72 34698 12148 29527609
Cyanosis 58.17 16.07 69 34701 11198 29528559
Hypoventilation 57.76 16.07 38 34732 2803 29536954
Muscle rigidity 57.69 16.07 63 34707 9348 29530409
Post procedural fever 56.95 16.07 16 34754 128 29539629
Dyspnoea 56.76 16.07 196 34574 326536 29213221
Peripheral swelling 56.47 16.07 5 34765 63734 29476023
Febrile neutropenia 56.20 16.07 31 34739 112209 29427548
Cardio-respiratory arrest 55.96 16.07 158 34612 50443 29489314
Anhedonia 54.56 16.07 54 34716 7146 29532611
Neuropathy peripheral 54.54 16.07 9 34761 71018 29468739
Ventricular arrhythmia 53.63 16.07 44 34726 4560 29535197
Acute respiratory distress syndrome 52.94 16.07 96 34674 22839 29516918
Respiratory failure 52.68 16.07 240 34530 96891 29442866
Constipation 52.31 16.07 35 34735 114125 29425632
Tryptase increased 51.76 16.07 16 34754 184 29539573
Erythema 51.25 16.07 200 34570 75406 29464351
Malignant neoplasm progression 51.17 16.07 12 34758 73847 29465910
Resuscitation 50.94 16.07 26 34744 1186 29538571
Dystonia 50.82 16.07 60 34710 9689 29530068
Brain injury 50.66 16.07 46 34724 5466 29534291
Pulmonary alveolar haemorrhage 50.49 16.07 49 34721 6331 29533426
Weight increased 50.15 16.07 14 34756 76653 29463104
Disease progression 49.91 16.07 17 34753 81899 29457858
Dyskinesia 47.61 16.07 85 34685 19976 29519781
Neonatal respiratory depression 47.56 16.07 18 34752 394 29539363
Neuromuscular blockade 47.50 16.07 15 34755 186 29539571
Neutropenia 46.26 16.07 52 34718 131659 29408098
Oedema peripheral 45.78 16.07 33 34737 103524 29436233
Blood pressure measurement 45.37 16.07 14 34756 160 29539597
Blood lactic acid increased 45.10 16.07 44 34726 5722 29534035
Necrosis ischaemic 45.01 16.07 15 34755 223 29539534
Oxygen saturation immeasurable 44.69 16.07 10 34760 26 29539731
Sinus arrest 43.90 16.07 25 34745 1422 29538335
Hyperammonaemia 43.89 16.07 43 34727 5620 29534137
Feeling abnormal 43.85 16.07 6 34764 54439 29485318
Endotracheal intubation complication 43.76 16.07 16 34754 317 29539440
Insomnia 43.72 16.07 25 34745 88736 29451021
Product contamination 43.72 16.07 19 34751 600 29539157
Pneumonia 43.68 16.07 211 34559 319961 29219796
Back pain 43.41 16.07 34 34736 102250 29437507
White blood cell count decreased 43.22 16.07 22 34748 83340 29456417
Hepatorenal failure 43.14 16.07 18 34752 513 29539244
Acidosis 42.94 16.07 55 34715 9650 29530107
Hospitalisation 42.43 16.07 3 34767 45985 29493772
Cough 42.39 16.07 52 34718 126675 29413082
Type I hypersensitivity 42.18 16.07 22 34748 1050 29538707
Endotracheal intubation 40.88 16.07 30 34740 2639 29537118
Respiratory tract infection bacterial 40.65 16.07 18 34752 595 29539162
Pneumococcal sepsis 40.58 16.07 20 34750 846 29538911
Anaesthetic complication cardiac 40.06 16.07 9 34761 24 29539733
Anaphylactoid reaction 39.50 16.07 26 34744 1919 29537838
Urinary tract infection 39.18 16.07 18 34752 72336 29467421
Sinus tachycardia 38.55 16.07 66 34704 15003 29524754
Torsade de pointes 38.08 16.07 43 34727 6618 29533139
Burkholderia test positive 37.88 16.07 20 34750 979 29538778
Pancytopenia 37.41 16.07 26 34744 83142 29456615
Cardiac failure congestive 37.10 16.07 22 34748 76559 29463198
Emotional distress 37.06 16.07 62 34708 13833 29525924
Anticholinergic syndrome 37.05 16.07 19 34751 875 29538882
Coma blister 36.76 16.07 10 34760 70 29539687
Hypotonic-hyporesponsive episode 36.57 16.07 8 34762 18 29539739
Dehydration 36.39 16.07 49 34721 114699 29425058
Airway peak pressure increased 36.27 16.07 8 34762 19 29539738
Hypercapnia 36.03 16.07 32 34738 3694 29536063
Procedural haemorrhage 35.73 16.07 26 34744 2257 29537500
Opisthotonus 35.58 16.07 15 34755 439 29539318
Brugada syndrome 35.28 16.07 17 34753 684 29539073
Mean arterial pressure decreased 35.16 16.07 11 34759 132 29539625
Lactic acidosis 34.95 16.07 96 34674 30151 29509606
Urticaria 34.94 16.07 142 34628 54518 29485239
Paraesthesia 34.89 16.07 10 34760 53835 29485922
Haemodialysis 34.33 16.07 50 34720 9904 29529853
Increased bronchial secretion 34.23 16.07 22 34748 1559 29538198
Delirium 34.16 16.07 113 34657 39284 29500473
Post procedural haemorrhage 34.01 16.07 43 34727 7448 29532309
Pulmonary oedema 33.92 16.07 119 34651 42616 29497141
Therapeutic product effect prolonged 33.24 16.07 12 34758 229 29539528
Oculocardiac reflex 33.21 16.07 9 34761 62 29539695
Hepatitis fulminant 33.20 16.07 30 34740 3541 29536216
Multiple-drug resistance 32.84 16.07 31 34739 3869 29535888
Muscle spasms 32.52 16.07 18 34752 65064 29474693
Intracranial pressure increased 31.86 16.07 29 34741 3456 29536301
Superinfection 31.80 16.07 23 34747 1978 29537779
Spinal cord infarction 31.57 16.07 12 34758 266 29539491
Areflexia 31.41 16.07 26 34744 2728 29537029
Product contamination microbial 31.30 16.07 15 34755 596 29539161
Postoperative delirium 31.21 16.07 8 34762 43 29539714
Cellulitis 30.66 16.07 8 34762 45832 29493925
Chest pain 30.51 16.07 53 34717 111920 29427837
Metabolic disorder 30.41 16.07 29 34741 3666 29536091
Neuroleptic malignant syndrome 30.39 16.07 62 34708 16086 29523671
Sputum increased 30.28 16.07 22 34748 1905 29537852
Nodal rhythm 30.15 16.07 19 34751 1301 29538456
Symmetrical drug-related intertriginous and flexural exanthema 30.08 16.07 11 34759 218 29539539
Heparin-induced thrombocytopenia 29.94 16.07 33 34737 4946 29534811
Drug intolerance 29.53 16.07 10 34760 48369 29491388
PCO2 increased 29.41 16.07 14 34756 548 29539209
Post procedural hypotension 29.41 16.07 8 34762 56 29539701
Vomiting 29.39 16.07 139 34631 212121 29327636
Inappropriate schedule of product administration 29.30 16.07 8 34762 44464 29495293
Chromaturia 28.79 16.07 53 34717 12749 29527008
Electrocardiogram ST-T segment elevation 28.74 16.07 5 34765 0 29539757
Syncope 28.68 16.07 32 34738 81339 29458418
Influenza 28.61 16.07 7 34763 41874 29497883
Sodium retention 28.05 16.07 8 34762 68 29539689
Plasma cell myeloma 27.82 16.07 5 34765 37110 29502647
Suicidal ideation 27.54 16.07 4 34766 34712 29505045
Pneumomediastinum 27.49 16.07 20 34750 1736 29538021
Electrocardiogram T wave inversion 27.37 16.07 21 34749 1976 29537781
Unresponsive to stimuli 27.31 16.07 78 34692 25048 29514709
Recurrence of neuromuscular blockade 27.31 16.07 9 34761 129 29539628
Hypotonia 27.27 16.07 37 34733 6865 29532892
Ischaemic cerebral infarction 26.88 16.07 16 34754 989 29538768
Balance disorder 26.84 16.07 5 34765 36165 29503592
Disseminated intravascular coagulation 26.74 16.07 67 34703 19913 29519844
Acute pulmonary oedema 26.26 16.07 36 34734 6743 29533014
Lower respiratory tract infection bacterial 26.21 16.07 11 34759 318 29539439
Disease complication 26.12 16.07 22 34748 2364 29537393
Coagulopathy 26.04 16.07 62 34708 17845 29521912
Mucosal ulceration 26.02 16.07 15 34755 873 29538884
Renin increased 25.96 16.07 8 34762 91 29539666
Stomatitis 25.75 16.07 6 34764 37107 29502650
Gait disturbance 25.68 16.07 29 34741 73320 29466437
Electrocardiogram QT prolonged 25.61 16.07 97 34673 36040 29503717
Locked-in syndrome 25.53 16.07 10 34760 241 29539516
Pseudocholinesterase deficiency 25.48 16.07 6 34764 21 29539736
Generalised tonic-clonic seizure 25.43 16.07 64 34706 19075 29520682
Depression 25.35 16.07 38 34732 85109 29454648
Motor neurone disease 25.17 16.07 11 34759 352 29539405
Abdominal pain upper 24.96 16.07 21 34749 60972 29478785
Acidosis hyperchloraemic 24.94 16.07 11 34759 360 29539397
Cerebral ischaemia 24.73 16.07 32 34738 5671 29534086
Diabetes mellitus 24.71 16.07 8 34762 39823 29499934
Hepatic cytolysis 24.64 16.07 39 34731 8308 29531449
Neonatal hypoxia 24.61 16.07 11 34759 372 29539385
Subcutaneous emphysema 24.48 16.07 15 34755 977 29538780
Atrioventricular block complete 24.44 16.07 38 34732 7973 29531784
Hypothermia 24.34 16.07 41 34729 9198 29530559
Stoma closure 24.32 16.07 8 34762 114 29539643
Suspected product contamination 24.29 16.07 7 34763 62 29539695
Local anaesthetic systemic toxicity 24.26 16.07 9 34761 186 29539571
Paroxysmal sympathetic hyperactivity 24.11 16.07 6 34764 28 29539729
Contusion 23.72 16.07 4 34766 31091 29508666
Weight bearing difficulty 23.64 16.07 14 34756 857 29538900
Bronchitis 23.60 16.07 7 34763 36861 29502896
Chills 23.56 16.07 154 34616 71146 29468611
Systemic inflammatory response syndrome 23.53 16.07 32 34738 5949 29533808
Blood catecholamines increased 23.25 16.07 5 34765 10 29539747
Dyspnoea exertional 23.23 16.07 7 34763 36483 29503274
Rash maculo-papular 23.17 16.07 72 34698 24217 29515540
Unwanted awareness during anaesthesia 23.14 16.07 6 34764 34 29539723
Myoglobin blood increased 23.10 16.07 19 34751 1976 29537781
Suspected product quality issue 23.07 16.07 8 34762 135 29539622
Haemoglobin decreased 23.06 16.07 59 34711 108316 29431441
End-tidal CO2 increased 22.93 16.07 5 34765 11 29539746
Post-injection delirium sedation syndrome 22.91 16.07 11 34759 439 29539318
Electroencephalogram abnormal 22.47 16.07 20 34750 2315 29537442
Upper airway obstruction 22.42 16.07 12 34758 604 29539153
Coronary artery disease 22.39 16.07 12 34758 44178 29495579
Conversion disorder 22.35 16.07 10 34760 339 29539418
Pruritus 22.34 16.07 67 34703 116782 29422975
Hyperventilation 22.27 16.07 20 34750 2342 29537415
Brain death 22.21 16.07 20 34750 2350 29537407
Trismus 22.19 16.07 20 34750 2353 29537404
Periorbital swelling 22.05 16.07 10 34760 350 29539407
Hypoglycaemia 21.88 16.07 15 34755 48331 29491426
Neutrophil count decreased 21.83 16.07 12 34758 43555 29496202
Septic shock 21.82 16.07 137 34633 62423 29477334
Mechanical ventilation 21.57 16.07 17 34753 1663 29538094
Ventricular extrasystoles 21.55 16.07 42 34728 10540 29529217
Laryngeal oedema 21.51 16.07 22 34748 3026 29536731
Musculoskeletal pain 21.49 16.07 4 34766 28949 29510808
Acute kidney injury 21.17 16.07 433 34337 264834 29274923
Hyperthermia 21.15 16.07 39 34731 9391 29530366
Long QT syndrome 21.05 16.07 19 34751 2239 29537518
Unevaluable event 21.04 16.07 80 34690 29771 29509986
Neuromyopathy 20.68 16.07 13 34757 886 29538871
Herpes zoster 20.57 16.07 5 34765 30047 29509710
Dialysis 20.17 16.07 40 34730 10168 29529589
Loss of personal independence in daily activities 20.02 16.07 3 34767 25437 29514320
Nystagmus 19.98 16.07 25 34745 4284 29535473
Continuous haemodiafiltration 19.90 16.07 13 34757 947 29538810
Incorrect drug administration rate 19.80 16.07 14 34756 1162 29538595
Epistaxis 19.72 16.07 19 34751 51685 29488072
Air embolism 19.67 16.07 7 34763 128 29539629
Congenital megaureter 19.67 16.07 7 34763 128 29539629
Electrocardiogram ST segment depression 19.62 16.07 18 34752 2167 29537590
Chronic obstructive pulmonary disease 19.50 16.07 12 34758 40943 29498814
Malignant catatonia 19.34 16.07 8 34762 223 29539534
Premature recovery from anaesthesia 19.33 16.07 4 34766 6 29539751
Chest X-ray abnormal 19.19 16.07 23 34747 3771 29535986
Systolic anterior motion of mitral valve 19.19 16.07 5 34765 29 29539728
Priapism 19.17 16.07 25 34745 4463 29535294
Migraine with aura 19.10 16.07 10 34760 481 29539276
Lymphadenectomy 18.98 16.07 8 34762 234 29539523
General physical health deterioration 18.93 16.07 60 34710 102797 29436960
Treatment failure 18.76 16.07 10 34760 36929 29502828
Drug withdrawal syndrome 18.74 16.07 55 34715 17929 29521828
Sedation complication 18.71 16.07 14 34756 1268 29538489
Eosinophilia 18.70 16.07 63 34707 22098 29517659
Capillary nail refill test abnormal 18.63 16.07 5 34765 33 29539724
Drug ineffective 18.57 16.07 558 34212 362612 29177145
Seizure 18.55 16.07 179 34591 92944 29446813
Oliguria 18.35 16.07 32 34738 7380 29532377
Urinary bladder rupture 18.33 16.07 6 34764 84 29539673
Clonus 18.32 16.07 18 34752 2360 29537397
Fear of death 18.19 16.07 10 34760 531 29539226
Skin test negative 18.14 16.07 5 34765 37 29539720
Renal impairment 18.05 16.07 160 34610 81173 29458584
Eye movement disorder 18.03 16.07 22 34748 3674 29536083
Sinusitis 17.89 16.07 9 34761 34341 29505416
Pleural effusion 17.84 16.07 36 34734 71872 29467885
Dry skin 17.77 16.07 3 34767 23304 29516453
Sinus bradycardia 17.77 16.07 41 34729 11562 29528195
Hyperleukocytosis 17.74 16.07 15 34755 1620 29538137
Electrocardiogram QRS complex prolonged 17.72 16.07 23 34747 4087 29535670
Bronchial disorder 17.67 16.07 13 34757 1148 29538609
Depressed level of consciousness 17.60 16.07 88 34682 36854 29502903
Hyperkalaemia 17.55 16.07 128 34642 61264 29478493
Transcranial electrical motor evoked potential monitoring abnormal 17.46 16.07 4 34766 12 29539745
Haematuria traumatic 17.37 16.07 7 34763 182 29539575
Mydriasis 17.37 16.07 28 34742 6057 29533700
Pupil fixed 17.27 16.07 15 34755 1681 29538076
Klebsiella infection 17.25 16.07 31 34739 7318 29532439
Light anaesthesia 17.24 16.07 3 34767 0 29539757
Therapeutic response prolonged 17.24 16.07 3 34767 0 29539757
Hypernatraemia 17.14 16.07 31 34739 7355 29532402
Apnoeic attack 17.03 16.07 8 34762 304 29539453
Anaesthetic complication pulmonary 16.99 16.07 4 34766 14 29539743
Skin test positive 16.98 16.07 8 34762 306 29539451
Obstructive airways disorder 16.95 16.07 39 34731 10977 29528780
Respiratory alkalosis 16.91 16.07 14 34756 1469 29538288
Complication of device removal 16.81 16.07 5 34765 50 29539707
Sleep disorder 16.80 16.07 4 34766 24382 29515375
Aspiration 16.74 16.07 37 34733 10143 29529614
Mixed liver injury 16.69 16.07 16 34754 2035 29537722
Hyponatraemia 16.66 16.07 34 34736 67599 29472158
Cardiogenic shock 16.59 16.07 55 34715 19135 29520622
Myocardial infarction 16.57 16.07 70 34700 110226 29429531
Abdominal compartment syndrome 16.52 16.07 11 34759 828 29538929
Atonic urinary bladder 16.19 16.07 4 34766 18 29539739
Hepatitis acute 16.13 16.07 28 34742 6434 29533323

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaphylactic shock 3676.44 14.01 1321 64752 29007 64403652
Anaphylactic reaction 1720.67 14.01 996 65077 67668 64364991
Propofol infusion syndrome 1666.48 14.01 376 65697 1241 64431418
Hypotension 1142.92 14.01 1658 64415 379316 64053343
Cardiac arrest 1107.53 14.01 1052 65021 153012 64279647
Bronchospasm 1037.45 14.01 486 65587 21196 64411463
Hyperthermia malignant 820.22 14.01 232 65841 2227 64430432
Bradycardia 630.70 14.01 688 65385 117531 64315128
Delayed recovery from anaesthesia 628.69 14.01 170 65903 1358 64431301
Serotonin syndrome 589.99 14.01 413 65660 38869 64393790
Circulatory collapse 545.03 14.01 371 65702 33361 64399298
Tachycardia 532.71 14.01 709 65364 148870 64283789
Rhabdomyolysis 454.75 14.01 514 65559 91212 64341447
Fatigue 446.68 14.01 110 65963 748620 63684039
Neuromuscular block prolonged 366.12 14.01 101 65972 876 64431783
Stress cardiomyopathy 356.58 14.01 179 65894 9078 64423581
Ventricular fibrillation 351.47 14.01 248 65825 23612 64409047
Anaesthetic complication 329.25 14.01 117 65956 2462 64430197
Arthralgia 327.21 14.01 36 66037 442224 63990435
Diarrhoea 325.67 14.01 168 65905 722536 63710123
Pulseless electrical activity 324.13 14.01 187 65886 12552 64420107
Status epilepticus 318.69 14.01 225 65848 21438 64411221
Metabolic acidosis 315.30 14.01 376 65697 70582 64362077
Haemodynamic instability 309.51 14.01 192 65881 14720 64417939
Ventricular tachycardia 302.16 14.01 263 65810 34002 64398657
Shock 288.86 14.01 269 65804 37971 64394688
Blood pressure decreased 287.28 14.01 396 65677 85803 64346856
Drug interaction 283.46 14.01 914 65159 361169 64071490
Fall 270.84 14.01 50 66023 416776 64015883
Oxygen saturation decreased 262.14 14.01 426 65647 106750 64325909
Myoclonus 254.76 14.01 209 65864 24909 64407750
Multiple organ dysfunction syndrome 239.77 14.01 397 65676 101016 64331643
Electrocardiogram ST segment elevation 229.65 14.01 123 65950 7136 64425523
Airway complication of anaesthesia 223.07 14.01 57 66016 355 64432304
Procedural hypotension 219.85 14.01 80 65993 1806 64430853
Diabetes insipidus 215.01 14.01 101 65972 4420 64428239
Hypoxia 202.88 14.01 341 65732 87808 64344851
Apnoea 200.73 14.01 128 65945 10294 64422365
Joint swelling 197.06 14.01 5 66068 215377 64217282
Respiratory depression 196.76 14.01 175 65898 23268 64409391
Headache 193.13 14.01 156 65917 529311 63903348
Anaphylactoid shock 188.97 14.01 57 66016 697 64431962
Post procedural complication 186.40 14.01 163 65910 21190 64411469
Blood creatine phosphokinase increased 181.59 14.01 260 65813 58298 64374361
Respiratory acidosis 177.39 14.01 116 65957 9739 64422920
Pain in extremity 175.28 14.01 47 66026 303038 64129621
Dystonia 174.79 14.01 149 65924 18716 64413943
Dizziness 173.34 14.01 114 65959 430049 64002610
Laryngospasm 173.25 14.01 80 65993 3365 64429294
Procedural complication 169.91 14.01 101 65972 7164 64425495
Nasopharyngitis 167.36 14.01 8 66065 196065 64236594
Malaise 166.53 14.01 100 65973 396147 64036512
Nausea 165.05 14.01 350 65723 785450 63647209
Intestinal ischaemia 156.18 14.01 114 65959 11435 64421224
Decreased appetite 154.56 14.01 48 66025 281241 64151418
Arteriospasm coronary 146.44 14.01 83 65990 5382 64427277
Peripheral swelling 144.77 14.01 21 66052 209132 64223527
Drug intolerance 142.12 14.01 14 66059 187978 64244681
Product dose omission issue 140.89 14.01 17 66056 194730 64237929
Alopecia 137.49 14.01 8 66065 165682 64266977
Weight increased 137.48 14.01 26 66047 213322 64219337
Hypoventilation 136.56 14.01 82 65991 5924 64426735
Dyspnoea 136.30 14.01 338 65735 718336 63714323
Rheumatoid arthritis 136.13 14.01 8 66065 164286 64268373
Abdominal discomfort 134.17 14.01 15 66058 182307 64250352
Tryptase increased 133.54 14.01 39 66034 423 64432236
Anaphylactoid reaction 132.49 14.01 74 65999 4664 64427995
Intensive care unit acquired weakness 132.39 14.01 54 66019 1673 64430986
Cardio-respiratory arrest 131.60 14.01 303 65770 98090 64334569
Anaesthetic complication neurological 127.18 14.01 39 66034 506 64432153
Unwanted awareness during anaesthesia 123.31 14.01 33 66040 252 64432407
Torsade de pointes 121.26 14.01 117 65956 17246 64415413
Type I hypersensitivity 119.94 14.01 63 66010 3511 64429148
Hypertriglyceridaemia 119.42 14.01 96 65977 11109 64421550
Generalised tonic-clonic seizure 119.20 14.01 174 65899 39683 64392976
Respiratory failure 116.81 14.01 397 65676 160786 64271873
Weight decreased 114.59 14.01 76 65997 285663 64146996
Vasoplegia syndrome 110.96 14.01 55 66018 2712 64429947
Respiratory arrest 110.09 14.01 196 65877 52789 64379870
Anticholinergic syndrome 109.85 14.01 54 66019 2615 64430044
Pain 109.79 14.01 254 65819 553257 63879402
Hypoxic-ischaemic encephalopathy 109.14 14.01 76 65997 7076 64425583
Trigemino-cardiac reflex 109.12 14.01 29 66044 215 64432444
Asthenia 107.96 14.01 170 65903 427874 64004785
Opisthotonus 107.20 14.01 36 66037 635 64432024
Brain oedema 106.32 14.01 122 65951 21953 64410706
Unresponsive to stimuli 105.46 14.01 187 65886 50206 64382453
Sinusitis 104.88 14.01 13 66060 145915 64286744
Toxic epidermal necrolysis 103.61 14.01 157 65916 37009 64395650
Drug reaction with eosinophilia and systemic symptoms 101.84 14.01 192 65881 54025 64378634
Constipation 101.79 14.01 54 66019 229283 64203376
Agitation 100.86 14.01 256 65817 88111 64344548
Labile blood pressure 100.55 14.01 47 66026 2033 64430626
Pulse absent 100.38 14.01 79 65994 8867 64423792
Arthropathy 99.86 14.01 6 66067 120961 64311698
Fear 99.72 14.01 113 65960 20058 64412601
Death 99.35 14.01 217 65856 482488 63950171
Anaesthetic complication pulmonary 98.35 14.01 21 66052 49 64432610
PCO2 increased 97.44 14.01 43 66030 1624 64431035
Muscle rigidity 96.96 14.01 104 65969 17369 64415290
Acute respiratory distress syndrome 96.75 14.01 156 65917 38779 64393880
Renal injury 96.67 14.01 98 65975 15331 64417328
Erythema 96.13 14.01 413 65660 186657 64246002
Myoglobin urine present 95.63 14.01 32 66041 558 64432101
Dyskinesia 94.06 14.01 155 65918 39233 64393426
Clonus 93.82 14.01 65 66008 6002 64426657
Endotracheal intubation complication 93.36 14.01 33 66040 683 64431976
Insomnia 93.19 14.01 43 66030 197793 64234866
Tachypnoea 92.84 14.01 125 65948 26446 64406213
Pruritus 88.68 14.01 114 65959 312286 64120373
Abdominal pain 88.66 14.01 114 65959 312261 64120398
Negative pressure pulmonary oedema 87.52 14.01 24 66049 203 64432456
Contusion 87.39 14.01 8 66065 113957 64318702
Urinary tract infection 87.03 14.01 66 66007 231530 64201129
Pulmonary oedema 86.75 14.01 225 65848 78449 64354210
Necrosis ischaemic 86.68 14.01 34 66039 949 64431710
Sinus tachycardia 85.54 14.01 133 65940 32055 64400604
Neutropenia 85.39 14.01 72 66001 239552 64193107
Disseminated intravascular coagulation 85.04 14.01 133 65940 32215 64400444
Kounis syndrome 83.91 14.01 47 66026 2978 64429681
Neuromuscular blockade 83.79 14.01 28 66045 486 64432173
Infusion related reaction 83.47 14.01 32 66041 164435 64268224
Cardiogenic shock 83.41 14.01 132 65941 32295 64400364
Mydriasis 82.96 14.01 90 65983 15222 64417437
Neuropathy peripheral 80.81 14.01 12 66061 117513 64315146
Multiple-drug resistance 80.78 14.01 61 66012 6441 64426218
Influenza 80.30 14.01 8 66065 106523 64326136
Anaemia 78.86 14.01 169 65904 378511 64054148
Pneumonia 78.25 14.01 302 65771 559274 63873385
Back pain 77.69 14.01 85 65988 250086 64182573
Hepatorenal failure 77.56 14.01 33 66040 1139 64431520
Injection site pain 77.47 14.01 11 66062 111397 64321262
Oedema peripheral 76.40 14.01 62 66011 210255 64222404
Laryngeal oedema 75.92 14.01 61 66012 7052 64425607
Injury 75.45 14.01 173 65900 55819 64376840
Therapeutic product effect prolonged 75.28 14.01 26 66047 501 64432158
Anhedonia 75.03 14.01 81 65992 13625 64419034
Bronchitis 75.01 14.01 11 66062 108732 64323927
Blood lactic acid increased 74.35 14.01 71 66002 10330 64422329
Oliguria 74.34 14.01 83 65990 14493 64418166
Swelling 73.64 14.01 36 66037 160182 64272477
Stomatitis 73.52 14.01 12 66061 109593 64323066
Arthritis 72.85 14.01 3 66070 83811 64348848
Post procedural haemorrhage 72.53 14.01 76 65997 12355 64420304
Disease progression 71.17 14.01 28 66045 141652 64291007
Seizure 70.54 14.01 348 65725 166544 64266115
Malignant neoplasm progression 70.07 14.01 15 66058 112856 64319803
Hypercapnia 69.69 14.01 60 66013 7634 64425025
Electrocardiogram QT prolonged 68.68 14.01 208 65865 79240 64353419
Abdominal pain upper 68.18 14.01 48 66025 174982 64257677
Cyanosis 68.09 14.01 98 65975 22057 64410602
Pulmonary alveolar haemorrhage 66.82 14.01 65 66008 9673 64422986
Procedural haemorrhage 66.80 14.01 46 66027 4206 64428453
Mitochondrial DNA mutation 66.72 14.01 20 66053 239 64432420
Systemic lupus erythematosus 66.72 14.01 3 66070 77609 64355050
Ventricular extrasystoles 66.70 14.01 86 65987 17443 64415216
Gait disturbance 66.02 14.01 48 66025 172107 64260552
Upper airway obstruction 65.72 14.01 30 66043 1228 64431431
Suspected product quality issue 65.61 14.01 20 66053 254 64432405
Ventricular arrhythmia 65.49 14.01 57 66016 7358 64425301
Acute pulmonary oedema 65.43 14.01 73 66000 12736 64419923
Cough 65.27 14.01 132 65941 302016 64130643
Postoperative delirium 65.15 14.01 18 66055 157 64432502
Coagulopathy 64.91 14.01 117 65956 31803 64400856
Dehydration 64.73 14.01 76 65997 216687 64215972
Chest pain 63.99 14.01 89 65984 235891 64196768
Intra-abdominal pressure increased 63.31 14.01 19 66054 228 64432431
Feeling abnormal 62.95 14.01 29 66044 133573 64299086
Electroencephalogram abnormal 62.84 14.01 48 66025 5155 64427504
Resuscitation 62.76 14.01 34 66039 2017 64430642
Febrile neutropenia 62.51 14.01 60 66013 187597 64245062
Delirium 62.50 14.01 184 65889 69010 64363649
Inappropriate schedule of product administration 62.13 14.01 10 66063 92276 64340383
Drug ineffective for unapproved indication 61.89 14.01 113 65960 31020 64401639
Post procedural fever 61.67 14.01 22 66051 468 64432191
Local anaesthetic systemic toxicity 61.48 14.01 24 66049 661 64431998
Septic shock 61.37 14.01 242 65831 105195 64327464
Acidosis 61.07 14.01 83 65990 17712 64414947
Psoriasis 60.90 14.01 3 66070 71700 64360959
Seizure like phenomena 60.84 14.01 31 66042 1621 64431038
Spinal muscular atrophy 60.05 14.01 19 66054 275 64432384
White blood cell count decreased 59.24 14.01 45 66028 157792 64274867
Musculoskeletal stiffness 59.21 14.01 26 66047 123180 64309479
Neuroleptic malignant syndrome 59.18 14.01 98 65975 24898 64407761
Anaesthetic complication cardiac 58.95 14.01 14 66059 61 64432598
Atrioventricular block complete 58.44 14.01 73 66000 14345 64418314
Contraindicated product administered 58.08 14.01 19 66054 107810 64324849
Renal impairment 58.08 14.01 283 65790 134734 64297925
Recurrence of neuromuscular blockade 57.99 14.01 17 66056 187 64432472
PO2 increased 57.88 14.01 29 66044 1463 64431196
Acidosis hyperchloraemic 57.74 14.01 23 66050 669 64431990
Stridor 56.76 14.01 44 66029 4830 64427829
Electrocardiogram QRS complex prolonged 54.80 14.01 57 66016 9187 64423472
Herpes zoster 54.63 14.01 8 66065 79179 64353480
Endotracheal intubation 53.91 14.01 39 66034 3856 64428803
Drug level changed 53.85 14.01 20 66053 479 64432180
Ventricular hypokinesia 53.58 14.01 52 66021 7717 64424942
Airway peak pressure increased 53.52 14.01 18 66055 319 64432340
Dyspepsia 53.40 14.01 9 66064 80303 64352356
Hyperammonaemia 53.28 14.01 58 66015 9846 64422813
Syncope 52.96 14.01 50 66023 157585 64275074
Carcinoid crisis 51.96 14.01 19 66054 435 64432224
Muscle spasms 51.91 14.01 41 66032 140982 64291677
Blood pH decreased 51.83 14.01 40 66033 4362 64428297
Haemodialysis 51.69 14.01 75 65998 17002 64415657
Skin test positive 51.54 14.01 24 66049 1029 64431630
Hepatocellular injury 51.53 14.01 131 65942 45104 64387555
Oculogyric crisis 50.93 14.01 32 66041 2506 64430153
Renal ischaemia 50.89 14.01 24 66049 1059 64431600
Loss of personal independence in daily activities 50.73 14.01 7 66066 72447 64360212
Lactic acidosis 50.48 14.01 158 65915 61252 64371407
Lower respiratory tract infection 50.38 14.01 17 66056 94597 64338062
Subcutaneous emphysema 50.15 14.01 27 66046 1582 64431077
Renal failure 49.96 14.01 338 65735 181350 64251309
Oxygen saturation immeasurable 49.77 14.01 11 66062 32 64432627
Gastrointestinal disorder 49.75 14.01 15 66058 89694 64342965
Hyperreflexia 49.59 14.01 48 66025 7100 64425559
Foetal death 49.21 14.01 44 66029 5886 64426773
Urticaria 49.18 14.01 288 65785 147029 64285630
Mucosal inflammation 49.04 14.01 4 66069 62580 64370079
Hospitalisation 48.75 14.01 9 66064 75198 64357461
Systemic inflammatory response syndrome 48.32 14.01 56 66017 10179 64422480
Encephalopathy 48.04 14.01 151 65922 58668 64373991
Discomfort 47.70 14.01 12 66061 80866 64351793
Pneumatosis 47.54 14.01 21 66052 795 64431864
Ischaemic cerebral infarction 46.36 14.01 28 66045 2044 64430615
Brain injury 46.18 14.01 54 66019 9911 64422748
Vomiting 46.14 14.01 353 65720 550764 63881895
Hepatic ischaemia 46.04 14.01 22 66051 1000 64431659
Suspected product contamination 46 14.01 12 66061 82 64432577
Cardiac output decreased 45.98 14.01 26 66047 1678 64430981
Wound 45.78 14.01 11 66062 76466 64356193
Amylase increased 45.74 14.01 53 66020 9632 64423027
End-tidal CO2 decreased 45.53 14.01 10 66063 28 64432631
Autonomic nervous system imbalance 45.30 14.01 36 66037 4096 64428563
Mean arterial pressure decreased 45.18 14.01 16 66057 333 64432326
Product contamination 45.10 14.01 22 66051 1047 64431612
Brugada syndrome 44.93 14.01 22 66051 1056 64431603
Musculoskeletal pain 44.35 14.01 14 66059 81280 64351379
Infection 44.10 14.01 76 65997 184804 64247855
Emotional distress 43.82 14.01 107 65966 35931 64396728
Nasal congestion 43.62 14.01 5 66068 59653 64373006
Mental status changes postoperative 43.55 14.01 13 66060 153 64432506
Balance disorder 43.11 14.01 16 66057 83910 64348749
Sinus arrest 42.90 14.01 31 66042 3059 64429600
Product contamination microbial 42.83 14.01 20 66053 863 64431796
Injection site erythema 42.74 14.01 10 66063 70790 64361869
Depression 42.22 14.01 77 65996 183214 64249445
Brain death 42.19 14.01 37 66036 4824 64427835
Macroglossia 42.07 14.01 21 66052 1051 64431608
Cardiac failure congestive 42.03 14.01 43 66030 130537 64302122
Acute kidney injury 41.82 14.01 669 65404 448571 63984088
Exposure during pregnancy 41.78 14.01 174 65899 77501 64355158
Unmasking of previously unidentified disease 41.41 14.01 24 66049 1623 64431036
Electrocardiogram ST segment depression 41.33 14.01 35 66038 4354 64428305
Diabetes mellitus 40.91 14.01 9 66064 66465 64366194
Coma 40.83 14.01 188 65885 87427 64345232
Blood gases abnormal 40.79 14.01 20 66053 963 64431696
Blood pressure immeasurable 40.68 14.01 25 66048 1883 64430776
Hypocapnia 40.33 14.01 17 66056 573 64432086
Hypoaesthesia 40.20 14.01 50 66023 139058 64293601
Chromaturia 39.89 14.01 78 65995 22533 64410126
Aspiration 39.70 14.01 66 66007 16819 64415840
Wrong product administered 39.43 14.01 44 66029 7676 64424983
Hepatitis acute 39.36 14.01 58 66015 13331 64419328
Pseudocholinesterase deficiency 39.32 14.01 12 66061 153 64432506
Gastrooesophageal reflux disease 39.23 14.01 18 66055 83125 64349534
Sinus bradycardia 39.21 14.01 78 65995 22815 64409844
Air embolism 38.98 14.01 15 66058 397 64432262
Left ventricle outflow tract obstruction 38.93 14.01 14 66059 305 64432354
Oxygen saturation abnormal 38.91 14.01 31 66042 3540 64429119
Unevaluable event 38.85 14.01 127 65946 50362 64382297
Respiratory distress 38.81 14.01 130 65943 52201 64380458
Muscle relaxant therapy 38.56 14.01 12 66061 164 64432495
Skin test negative 38.52 14.01 9 66064 36 64432623
Thyrotoxic crisis 38.38 14.01 20 66053 1096 64431563
Respiratory tract infection bacterial 37.94 14.01 18 66055 805 64431854
Hyperkalaemia 37.91 14.01 204 65869 100925 64331734
Angioedema 37.67 14.01 144 65929 61677 64370982
Palpitations 37.67 14.01 31 66042 104457 64328202
Acute postoperative sialadenitis 37.22 14.01 9 66064 43 64432616
Hepatitis 37.20 14.01 117 65956 45465 64387194
Hepatic failure 37.08 14.01 133 65940 55261 64377398
Pancytopenia 36.90 14.01 56 66017 143253 64289406
Confusion postoperative 36.70 14.01 12 66061 194 64432465
Long QT syndrome 36.57 14.01 35 66038 5104 64427555
Hypotonia 36.53 14.01 51 66022 11161 64421498
Procedural hypertension 36.38 14.01 13 66060 278 64432381
Eosinophilia 36.05 14.01 103 65970 37973 64394686
Increased bronchial secretion 36.05 14.01 27 66046 2815 64429844
Intracranial pressure increased 35.99 14.01 40 66033 6949 64425710
Blood pressure measurement 35.99 14.01 14 66059 382 64432277
Hepatitis fulminant 35.96 14.01 38 66035 6236 64426423
Asthma 35.91 14.01 27 66046 95198 64337461
Nodal rhythm 35.78 14.01 27 66046 2847 64429812
Chronic obstructive pulmonary disease 35.73 14.01 14 66059 71034 64361625
Dry mouth 35.56 14.01 9 66064 60409 64372250
Mobility decreased 35.49 14.01 22 66051 85818 64346841
Chest discomfort 35.40 14.01 40 66033 116066 64316593
Post-injection delirium sedation syndrome 35.38 14.01 15 66058 513 64432146
Arrhythmia 35.33 14.01 127 65946 52817 64379842
Perforation 35.04 14.01 19 66054 1129 64431530
Rash maculo-papular 35.03 14.01 117 65956 46909 64385750
Incorrect drug administration rate 34.87 14.01 26 66047 2693 64429966
Tonic clonic movements 34.79 14.01 23 66050 1966 64430693
Dyspnoea exertional 34.73 14.01 16 66057 73714 64358945
Hypernatraemia 34.68 14.01 52 66021 12137 64420522
Neck pain 34.65 14.01 10 66063 61523 64371136
Myoglobin blood increased 34.63 14.01 26 66047 2721 64429938
Myoglobinuria 34.62 14.01 18 66055 982 64431677
Therapeutic product effect incomplete 34.54 14.01 33 66040 103449 64329210
Hepatic cytolysis 34.49 14.01 56 66017 13993 64418666
Acute generalised exanthematous pustulosis 34.47 14.01 56 66017 14002 64418657
Oculocardiac reflex 34.44 14.01 9 66064 62 64432597
Hyperthermia 34.20 14.01 59 66014 15491 64417168
Spinal cord infarction 34.18 14.01 15 66058 559 64432100
Upper respiratory tract infection 33.96 14.01 16 66057 72769 64359890
Gene mutation 33.83 14.01 23 66050 2059 64430600
Suicidal ideation 33.65 14.01 13 66060 66529 64366130
Transcranial electrical motor evoked potential monitoring abnormal 33.52 14.01 7 66066 14 64432645
Hepatorenal syndrome 33.50 14.01 29 66044 3717 64428942
Plasma cell myeloma 33.34 14.01 4 66069 46071 64386588
Symmetrical drug-related intertriginous and flexural exanthema 33.04 14.01 15 66058 606 64432053
Premature recovery from anaesthesia 32.88 14.01 6 66067 3 64432656
Partial seizures 32.87 14.01 39 66034 7268 64425391
Laryngeal stenosis 32.24 14.01 16 66057 791 64431868
Ultrasound ovary abnormal 31.75 14.01 9 66064 87 64432572
Myotonia 31.61 14.01 11 66062 217 64432442
Rhinorrhoea 31.53 14.01 11 66062 59958 64372701
Drug ineffective 31.48 14.01 1102 64971 839145 63593514
Premature delivery 31.43 14.01 63 66010 18526 64414133
Systolic anterior motion of mitral valve 31.42 14.01 8 66065 49 64432610
Atrioventricular dissociation 31.35 14.01 12 66061 313 64432346
Dry skin 31.33 14.01 7 66066 51154 64381505
Fluid retention 31.23 14.01 11 66062 59595 64373064
Neoplasm progression 31.06 14.01 3 66070 40961 64391698
Paralysis 30.92 14.01 48 66025 11547 64421112
Hypothermia 30.87 14.01 65 66008 19791 64412868
Maternal exposure during delivery 30.75 14.01 16 66057 874 64431785
Obstructive airways disorder 30.52 14.01 71 66002 23114 64409545
Depressed level of consciousness 30.33 14.01 164 65909 81272 64351387
Impaired healing 30.27 14.01 12 66061 60461 64372198
Cystitis 30.16 14.01 4 66069 42671 64389988
Pneumococcal sepsis 30.15 14.01 18 66055 1286 64431373
Haemoglobin decreased 29.98 14.01 101 65972 194962 64237697
General physical health deterioration 29.98 14.01 108 65965 204317 64228342
Areflexia 29.90 14.01 31 66042 4976 64427683
Metabolic disorder 29.65 14.01 38 66035 7659 64425000
Post procedural hypotension 29.57 14.01 8 66065 64 64432595
Electrocardiogram ST-T segment elevation 29.42 14.01 5 66068 0 64432659
Bispectral index decreased 29.42 14.01 5 66068 0 64432659
Hypovolaemia 29.26 14.01 55 66018 15431 64417228
Nystagmus 29.17 14.01 41 66032 9027 64423632
Pneumomediastinum 29.12 14.01 24 66049 2876 64429783
Vertigo 29.07 14.01 12 66061 58999 64373660
Neutrophil count decreased 28.96 14.01 22 66051 77174 64355485
Hyperlactacidaemia 28.95 14.01 30 66043 4814 64427845
Oropharyngeal pain 28.89 14.01 29 66044 88838 64343821
Treatment failure 28.78 14.01 47 66026 116769 64315890
Depressed mood 28.62 14.01 4 66069 41008 64391651
Ventricular dysfunction 28.59 14.01 31 66042 5239 64427420
Supraventricular tachycardia 28.36 14.01 61 66012 18846 64413813
Hyperventilation 28.31 14.01 35 66038 6805 64425854
Priapism 28.18 14.01 27 66046 3943 64428716
Bone pain 28.16 14.01 7 66066 47565 64385094
Paraesthesia 27.96 14.01 60 66013 134462 64298197
Maternal exposure during pregnancy 27.91 14.01 181 65892 95703 64336956
Apnoeic attack 27.90 14.01 13 66060 558 64432101
Phrenic nerve paralysis 27.80 14.01 10 66063 218 64432441
Burkholderia test positive 27.73 14.01 13 66060 566 64432093
Irritable bowel syndrome 27.65 14.01 3 66070 37366 64395293
Epistaxis 27.59 14.01 36 66037 98095 64334564
End-tidal CO2 increased 27.53 14.01 6 66067 16 64432643
Gaze palsy 27.49 14.01 22 66051 2528 64430131
Coma blister 27.47 14.01 10 66063 226 64432433
Extrasystoles 27.45 14.01 34 66039 6624 64426035
Eye movement disorder 27.35 14.01 35 66038 7044 64425615
Pneumothorax 27.29 14.01 70 66003 24228 64408431
Acute hepatic failure 27.05 14.01 73 66000 26039 64406620
Muscle twitching 27.03 14.01 60 66013 18938 64413721
Troponin increased 27.02 14.01 53 66020 15346 64417313
Tongue oedema 26.99 14.01 32 66041 5958 64426701
Posterior reversible encephalopathy syndrome 26.70 14.01 67 66006 22879 64409780
Alanine aminotransferase increased 26.70 14.01 238 65835 138793 64293866
Atrioventricular block first degree 26.64 14.01 43 66030 10691 64421968
Myalgia 26.57 14.01 79 65994 158538 64274121
Locked-in syndrome 26.57 14.01 13 66060 623 64432036
Multiple sclerosis relapse 26.49 14.01 5 66068 41130 64391529
Atelectasis 26.05 14.01 74 65999 27192 64405467
Migraine 25.99 14.01 16 66057 62661 64369998
Fibrinolysis 25.98 14.01 7 66066 55 64432604
Cellulitis 25.68 14.01 35 66038 93622 64339037
Chemical peritonitis 25.66 14.01 10 66063 274 64432385
Blood pressure systolic decreased 25.63 14.01 38 66035 8782 64423877
Procedural nausea 25.49 14.01 13 66060 681 64431978
Blood bicarbonate decreased 25.49 14.01 28 66045 4801 64427858
Hyponatraemia 25.49 14.01 73 66000 148266 64284393
Extravasation 25.21 14.01 23 66050 3157 64429502
Transient ischaemic attack 25.21 14.01 7 66066 44175 64388484
Hot flush 25.15 14.01 8 66065 46227 64386432
Atrioventricular block second degree 25.08 14.01 32 66041 6422 64426237
Cardiovascular insufficiency 24.86 14.01 21 66052 2603 64430056
Respiratory alkalosis 24.86 14.01 25 66048 3872 64428787
Coma scale abnormal 24.79 14.01 35 66038 7739 64424920
Completed suicide 24.73 14.01 132 65941 224282 64208377
Dialysis 24.71 14.01 54 66019 16866 64415793
Burning sensation 24.62 14.01 10 66063 49654 64383005
Motor neurone disease 24.62 14.01 11 66062 428 64432231
Mechanical ventilation 24.55 14.01 20 66053 2358 64430301
Stoma closure 24.49 14.01 8 66065 129 64432530
Hypoglycaemia 24.24 14.01 34 66039 89858 64342801
Polyuria 24.00 14.01 45 66028 12598 64420061
Toxic encephalopathy 23.93 14.01 39 66034 9776 64422883
Heparin-induced thrombocytopenia 23.88 14.01 36 66037 8443 64424216
Productive cough 23.67 14.01 24 66049 73179 64359480
Therapeutic response prolonged 23.54 14.01 4 66069 0 64432659
Haematochezia 23.54 14.01 20 66053 66353 64366306
Vision blurred 23.52 14.01 35 66038 90281 64342378
Motor dysfunction 23.52 14.01 42 66031 11331 64421328
Osteoporosis 23.39 14.01 7 66066 42073 64390586
Rash pruritic 23.33 14.01 15 66058 57389 64375270
Osteonecrosis of jaw 23.31 14.01 6 66067 39819 64392840
Throat irritation 23.28 14.01 3 66070 32708 64399951
Superinfection 23.10 14.01 24 66049 3862 64428797
Nephrolithiasis 22.99 14.01 8 66065 43675 64388984
Pupil fixed 22.98 14.01 22 66051 3210 64429449
Procedural vomiting 22.96 14.01 12 66061 662 64431997
Vitamin K deficiency 22.87 14.01 12 66061 667 64431992
Myxoedema coma 22.74 14.01 12 66061 675 64431984
Shock haemorrhagic 22.74 14.01 52 66021 16739 64415920
Face oedema 22.49 14.01 66 66007 24695 64407964
Hyperammonaemic encephalopathy 22.24 14.01 24 66049 4034 64428625
Lymphadenopathy 22.19 14.01 10 66063 46676 64385983
Clonic convulsion 22.18 14.01 14 66059 1105 64431554
Myoclonic epilepsy 22.03 14.01 16 66057 1592 64431067
Chills 21.91 14.01 226 65847 137038 64295621
Oesophageal intramural haematoma 21.89 14.01 7 66066 105 64432554
Atrioventricular block 21.87 14.01 42 66031 11973 64420686
Coronary artery embolism 21.82 14.01 9 66064 287 64432372
C-reactive protein increased 21.72 14.01 40 66033 94869 64337790
Irregular breathing 21.64 14.01 10 66063 421 64432238
Ill-defined disorder 21.63 14.01 9 66064 44043 64388616
Extrapyramidal disorder 21.62 14.01 56 66017 19496 64413163
Cardiac massage 21.60 14.01 5 66068 19 64432640
Continuous haemodiafiltration 21.40 14.01 17 66056 1933 64430726
Abdominal compartment syndrome 21.38 14.01 15 66058 1413 64431246
Disease complication 21.30 14.01 24 66049 4231 64428428
Joint stiffness 21.13 14.01 3 66070 30401 64402258
Tracheal injury 21.07 14.01 6 66067 59 64432600
Dysgeusia 20.96 14.01 11 66062 47036 64385623
Aspartate aminotransferase increased 20.95 14.01 201 65872 119587 64313072
Angina pectoris 20.89 14.01 10 66063 45071 64387588
Cerebral ischaemia 20.87 14.01 37 66036 9925 64422734
Bezold-Jarisch reflex 20.83 14.01 5 66068 23 64432636
Drug withdrawal syndrome 20.82 14.01 75 65998 31216 64401443
Sputum increased 20.81 14.01 22 66051 3613 64429046
Orthostatic hypotension 20.71 14.01 11 66062 46727 64385932
Prinzmetal angina 20.69 14.01 15 66058 1488 64431171
Pneumonia staphylococcal 20.62 14.01 24 66049 4382 64428277
Tracheal deviation 20.47 14.01 6 66067 66 64432593
Sepsis syndrome 20.46 14.01 14 66059 1267 64431392
Femur fracture 20.25 14.01 5 66068 34130 64398529
Potentiating drug interaction 20.24 14.01 32 66041 7820 64424839
Cardiovascular disorder 20.21 14.01 48 66025 15833 64416826
Trismus 20.16 14.01 25 66048 4876 64427783
Haemodilution 20.07 14.01 7 66066 139 64432520
Eyelid oedema 20.03 14.01 41 66032 12238 64420421
Fear of death 20.01 14.01 14 66059 1313 64431346
Skin ulcer 20.01 14.01 10 66063 43964 64388695
Hypotensive transfusion reaction 19.99 14.01 6 66067 72 64432587
Agitation postoperative 19.77 14.01 6 66067 75 64432584
Malignant catatonia 19.72 14.01 9 66064 368 64432291
Myocardial infarction 19.70 14.01 95 65978 165726 64266933
Palmar-plantar erythrodysaesthesia syndrome 19.67 14.01 3 66070 28816 64403843
Blood catecholamines increased 19.59 14.01 5 66068 31 64432628
Transaminases increased 19.53 14.01 94 65979 44500 64388159
Fat embolism 19.50 14.01 9 66064 378 64432281
Basal cell carcinoma 19.33 14.01 4 66069 30834 64401825
Condition aggravated 19.32 14.01 267 65806 372159 64060500
Injection site reaction 19.23 14.01 12 66061 46652 64386007
Mechanical ventilation complication 19.19 14.01 5 66068 34 64432625
Incorrect route of product administration 19.19 14.01 60 66013 23238 64409421
Blood pressure fluctuation 19.18 14.01 15 66058 51856 64380803
Rectal haemorrhage 19.16 14.01 21 66052 61796 64370863
Histamine level increased 19.15 14.01 6 66067 84 64432575
Pain in jaw 18.95 14.01 9 66064 40746 64391913
Mucosal ulceration 18.83 14.01 15 66058 1712 64430947
Sleep disorder 18.82 14.01 20 66053 59689 64372970
Brain herniation 18.77 14.01 28 66045 6505 64426154
Gait inability 18.73 14.01 10 66063 42358 64390301
Chronic kidney disease 18.71 14.01 19 66054 57900 64374759
Phaeochromocytoma 18.68 14.01 10 66063 579 64432080
Product quality issue 18.63 14.01 70 66003 29729 64402930
Electrocardiogram T wave inversion 18.60 14.01 24 66049 4870 64427789
Electrocardiogram abnormal 18.53 14.01 42 66031 13439 64419220
Idiopathic interstitial pneumonia 18.35 14.01 7 66066 181 64432478
Inadequate aseptic technique in use of product 18.29 14.01 6 66067 98 64432561
Night sweats 18.29 14.01 7 66066 36039 64396620
Haematuria traumatic 18.27 14.01 7 66066 183 64432476
Left ventricular dysfunction 18.17 14.01 48 66025 16906 64415753
Altered state of consciousness 18.14 14.01 82 65991 37820 64394839
Glossoptosis 18.13 14.01 7 66066 187 64432472
Amaurosis 18.08 14.01 12 66061 1032 64431627
Visual impairment 18.06 14.01 30 66043 74047 64358612
Fibromyalgia 18.03 14.01 7 66066 35724 64396935
Intensive care unit delirium 17.96 14.01 5 66068 45 64432614
Capillary nail refill test abnormal 17.76 14.01 5 66068 47 64432612
Intentional self-injury 17.73 14.01 4 66069 29040 64403619
Tonic convulsion 17.71 14.01 15 66058 1866 64430793
Dry eye 17.71 14.01 4 66069 29015 64403644
Electrocardiogram repolarisation abnormality 17.70 14.01 15 66058 1867 64430792
Laryngeal obstruction 17.70 14.01 6 66067 109 64432550
Tryptase 17.65 14.01 3 66070 0 64432659
Bone marrow failure 17.56 14.01 14 66059 47938 64384721
Presyncope 17.50 14.01 7 66066 35082 64397577
Acquired macroglossia 17.50 14.01 7 66066 206 64432453
Lower respiratory tract infection bacterial 17.42 14.01 10 66063 664 64431995
Malabsorption 17.38 14.01 22 66051 4381 64428278
Nerve stimulation test abnormal 17.32 14.01 4 66069 15 64432644
Postoperative respiratory distress 17.32 14.01 4 66069 15 64432644
Neurological decompensation 17.24 14.01 22 66051 4414 64428245
Euthanasia 17.22 14.01 5 66068 53 64432606
Pancreatitis 17.02 14.01 112 65961 59495 64373164
Blood triglycerides increased 16.86 14.01 50 66023 18816 64413843
Sputum retention 16.79 14.01 11 66062 926 64431733
Conversion disorder 16.79 14.01 14 66059 1705 64430954
Cerebral hypoperfusion 16.76 14.01 10 66063 714 64431945
Euthyroid sick syndrome 16.74 14.01 5 66068 59 64432600
Red blood cell count decreased 16.65 14.01 15 66058 48371 64384288
Symptom masked 16.54 14.01 12 66061 1192 64431467
Supraventricular extrasystoles 16.49 14.01 25 66048 5890 64426769
Adverse event 16.48 14.01 10 66063 39479 64393180
Muscle necrosis 16.37 14.01 12 66061 1211 64431448
Memory impairment 16.36 14.01 40 66033 85642 64347017
Acute myeloid leukaemia 16.34 14.01 4 66069 27459 64405200
Blood glucose increased 16.30 14.01 49 66024 98024 64334635
Respiratory tract infection 16.29 14.01 9 66064 37398 64395261
Product use issue 16.28 14.01 90 65983 151625 64281034
Extubation 16.07 14.01 4 66069 22 64432637
Hemiplegic migraine 15.96 14.01 5 66068 70 64432589
Central-alveolar hypoventilation 15.78 14.01 4 66069 24 64432635
Blood bilirubin increased 15.75 14.01 107 65966 57446 64375213
Non-cardiogenic pulmonary oedema 15.65 14.01 12 66061 1296 64431363
Chest X-ray abnormal 15.55 14.01 26 66047 6655 64426004
Injection site haemorrhage 15.53 14.01 3 66070 24275 64408384
Weaning failure 15.42 14.01 9 66064 617 64432042
COVID-19 treatment 15.34 14.01 8 66065 439 64432220
Documented hypersensitivity to administered product 15.30 14.01 10 66063 838 64431821
Hypovolaemic shock 15.26 14.01 33 66040 10233 64422426
Injection site swelling 15.23 14.01 12 66061 41341 64391318
Neuralgia 15.22 14.01 4 66069 26180 64406479
Osteoarthritis 15.12 14.01 26 66047 63310 64369349
Light anaesthesia 15.12 14.01 3 66070 4 64432655
Product administered to patient of inappropriate age 15.09 14.01 21 66052 4580 64428079
Eyelid function disorder 14.99 14.01 7 66066 302 64432357
Acute respiratory failure 14.98 14.01 95 65978 49839 64382820
Gastritis 14.92 14.01 13 66060 42605 64390054
Somatosensory evoked potentials abnormal 14.86 14.01 6 66067 181 64432478
Decerebrate posture 14.86 14.01 6 66067 181 64432478
Limb injury 14.83 14.01 3 66070 23502 64409157
Myocardial stunning 14.83 14.01 6 66067 182 64432477
Mutism 14.75 14.01 14 66059 2020 64430639
Cytomegalovirus infection 14.74 14.01 10 66063 37189 64395470
Ammonia increased 14.73 14.01 26 66047 6951 64425708
Leukocytosis 14.72 14.01 77 65996 37663 64394996
Gastroenteritis 14.70 14.01 6 66067 29705 64402954
Device programming error 14.64 14.01 5 66068 93 64432566
Hepatic enzyme increased 14.54 14.01 76 65997 129867 64302792
Lipoedema 14.53 14.01 6 66067 192 64432467
Blood glucose decreased 14.49 14.01 3 66070 23120 64409539
Leukopenia 14.49 14.01 54 66019 101188 64331471
Acne 14.45 14.01 3 66070 23078 64409581
Bone cement implantation syndrome 14.36 14.01 3 66070 6 64432653
Athetosis 14.30 14.01 5 66068 100 64432559
Bronchial disorder 14.29 14.01 14 66059 2101 64430558
Gastric disorder 14.28 14.01 6 66067 29191 64403468
Pancreatitis necrotising 14.19 14.01 17 66056 3200 64429459
Bundle branch block right 14.12 14.01 32 66041 10237 64422422
Bradycardia foetal 14.12 14.01 5 66068 104 64432555
Arrhythmia supraventricular 14.03 14.01 13 66060 1820 64430839
Cerebrovascular accident 14.02 14.01 83 65990 137500 64295159

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N01AX10 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, GENERAL
Other general anesthetics
FDA EPC N0000175681 General Anesthetic
FDA PE N0000175975 General Anesthesia
CHEBI has role CHEBI:35623 anticonvulsants
CHEBI has role CHEBI:35717 hypnotics
CHEBI has role CHEBI:38877 intravenous anesthetics
CHEBI has role CHEBI:48578 free radical scavengers
CHEBI has role CHEBI:50919 antiemetico
MeSH PA D000777 Anesthetics
MeSH PA D018686 Anesthetics, Intravenous
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D006993 Hypnotics and Sedatives

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
General anesthesia indication 50697003
Sedation in Intubated Patients indication
Sedation as Adjunct to Anesthesia indication
Apnea contraindication 1023001
Asthenia contraindication 13791008
Hypovolemia contraindication 28560003
Low blood pressure contraindication 45007003
Cerebral arteriosclerosis contraindication 65312002
Decreased respiratory function contraindication 80954004
Epilepsy contraindication 84757009 DOID:1826
Myocardial dysfunction contraindication 233928007
Disorder of lipid metabolism contraindication 267431006
Hypoxia contraindication 389086002




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Anesthesia Indication
Cats General anesthesia for short procedures Indication
Cats Induction and maintenance of general anesthesia Indication
Cats General anesthesia Indication
Dogs Anesthesia Indication
Dogs General anesthesia for short procedures Indication
Dogs Induction and maintenance of general anesthesia Indication
Dogs General anesthesia Indication

🐶 Veterinary products

ProductApplicantIngredients
Rapanofal iVaoes Animal Health 1
PropoFlo, PropoFlo 28 Zoetis Inc. 1
PropoClear Zoetis Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.8 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
GABA-A receptor alpha-1/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR EC50 5.39 CHEMBL CHEMBL
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR EC50 5.70 CHEMBL CHEMBL
GABA A receptor alpha-2/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR EC50 4.95 CHEMBL CHEMBL
5-hydroxytryptamine receptor 2B GPCR Ki 5.46 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 5.22 DRUG MATRIX
Carbonic anhydrase 2 Enzyme IC50 4.01 WOMBAT-PK
Carbonic anhydrase 1 Enzyme IC50 4.71 WOMBAT-PK
Fatty-acid amide hydrolase 1 Enzyme IC50 4.28 WOMBAT-PK
Cytochrome P450 2C9 Enzyme IC50 4.91 WOMBAT-PK
Prostaglandin G/H synthase 1 Enzyme IC50 5.42 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 5.03 DRUG MATRIX
Arachidonate 15-lipoxygenase Enzyme IC50 5.12 DRUG MATRIX
Fatty-acid amide hydrolase 1 Enzyme IC50 4.85 CHEMBL
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 Ion channel BLOCKER IC50 5.20 IUPHAR
GABA-A receptor; anion channel Ion channel IC50 5.40 CHEMBL

External reference:

IDSource
4019500 VUID
N0000147620 NUI
D00549 KEGG_DRUG
4019500 VANDF
C0033487 UMLSCUI
CHEBI:44915 CHEBI
PFL PDB_CHEM_ID
CHEMBL526 ChEMBL_ID
DB00818 DRUGBANK_ID
D015742 MESH_DESCRIPTOR_UI
4943 PUBCHEM_CID
5073 INN_ID
5464 IUPHAR_LIGAND_ID
YI7VU623SF UNII
196459 RXNORM
14179 MMSL
5372 MMSL
65 MMSL
d00933 MMSL
003528 NDDF
387423006 SNOMEDCT_US
74674007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 0069-0209 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 26 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 0069-0234 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 26 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 0069-0248 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 26 sections
Propofol Lipuro HUMAN PRESCRIPTION DRUG LABEL 1 0264-4850 INJECTION, EMULSION 10 mg INTRAVENOUS unapproved drug other 3 sections
PROPOFOL HUMAN PRESCRIPTION DRUG LABEL 1 0404-9943 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 14 sections
PROPOFOL HUMAN PRESCRIPTION DRUG LABEL 1 0409-4699 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 26 sections
PROPOFOL HUMAN PRESCRIPTION DRUG LABEL 1 0409-4699 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 26 sections
PROPOFOL HUMAN PRESCRIPTION DRUG LABEL 1 0409-6010 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 26 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 0591-2136 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 26 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 0641-6194 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 24 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 0641-6195 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 24 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 0641-6196 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 24 sections
Fresenius Propoven 2% HUMAN PRESCRIPTION DRUG LABEL 1 18124-027 EMULSION 20 mg INTRAVENOUS unapproved drug other 2 sections
propofol HUMAN PRESCRIPTION DRUG LABEL 1 23155-345 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 23 sections
propofol HUMAN PRESCRIPTION DRUG LABEL 1 25021-608 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 27 sections
Propofol Injectable Emulsion HUMAN PRESCRIPTION DRUG LABEL 1 43598-265 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 22 sections
Propofol Injectable Emulsion HUMAN PRESCRIPTION DRUG LABEL 1 43598-548 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 22 sections
Propofol Injectable Emulsion HUMAN PRESCRIPTION DRUG LABEL 1 43598-549 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 22 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 50090-4569 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 27 sections
PROPOFOL HUMAN PRESCRIPTION DRUG LABEL 1 51662-1293 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 14 sections
PROPOFOL HUMAN PRESCRIPTION DRUG LABEL 1 51662-1470 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 14 sections
PROPOFOL HUMAN PRESCRIPTION DRUG LABEL 1 51662-1471 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 14 sections
PROPOFOL HUMAN PRESCRIPTION DRUG LABEL 1 52584-098 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 14 sections
Diprivan HUMAN PRESCRIPTION DRUG LABEL 1 52584-269 INJECTION, EMULSION 10 mg INTRAVENOUS NDA 12 sections
Propofol HUMAN PRESCRIPTION DRUG LABEL 1 52584-699 INJECTION, EMULSION 10 mg INTRAVENOUS ANDA 14 sections
Diprivan Human Prescription Drug Label 1 63323-269 INJECTION, EMULSION 10 mg INTRAVENOUS NDA 14 sections
Diprivan Human Prescription Drug Label 1 63323-269 INJECTION, EMULSION 10 mg INTRAVENOUS NDA 14 sections
Diprivan Human Prescription Drug Label 1 63323-269 INJECTION, EMULSION 10 mg INTRAVENOUS NDA 14 sections
Diprivan Human Prescription Drug Label 1 63323-269 INJECTION, EMULSION 10 mg INTRAVENOUS NDA 14 sections
Fresenius Propoven 2% HUMAN PRESCRIPTION DRUG LABEL 1 65219-427 EMULSION 20 mg INTRAVENOUS unapproved drug other 2 sections